Nuno Carvalho, Elisabete Carolino, Margarida Ferreira, Hélder Coelho, Catarina Rolo Santos, Ana Lúcia Barreira, Susana Henriques, Carlos Cardoso, Luís Moita, Paulo Matos Costa
The aetiology of acute appendicitis (AA), the most frequent abdominal surgical emergency, is still unclarified. Recent epidemiologic, clinical and laboratorial data point to an allergic component in the pathophysiology of AA. Mastocytes participate in the Th2 immune response, releasing inflammatory mediators from their granules upon stimulation by IgE-specific antigens. Among the well-known mediators are histamine, serotonin and tryptase, which are responsible for the clinical manifestations of allergies. We conducted a prospective single-centre study to measure histamine and serotonin (commercial ELISA kit) and tryptase (ImmunoCAP System) concentrations in appendicular lavage fluid (ALF) and serum...
January 29, 2024: International Journal of Molecular Sciences