keyword
https://read.qxmd.com/read/38542770/exploring-the-gut-microbiome-and-metabolome-in-individuals-with-alopecia-areata-disease
#1
JOURNAL ARTICLE
Olga Nikoloudaki, Daniela Pinto, Marta Acin Albiac, Giuseppe Celano, Alessio Da Ros, Maria De Angelis, Fabio Rinaldi, Marco Gobbetti, Raffaella Di Cagno
In recent years, heightened attention has been devoted to unravelling the intricate interplay between genetic and environmental factors shaping the gut microbiota and its significance for human health. This study delves into exploring the plausible connection between Alopecia Areata (AA), an autoimmune disease, and the dynamics of the gut microbiome. Examining a cohort of healthy adults and individuals with AA, both the gut microbiota composition and volatile organic compound (VOC) metabolites from faeces and urine were analysed...
March 15, 2024: Nutrients
https://read.qxmd.com/read/38482982/unhinged-a-prospective-perspective-on-being-unsafe
#2
JOURNAL ARTICLE
Tiffany N Houck
Given the unprecedented events unfolding around the globe over the past four years, psychoanalytic communities near and far have sought to ask and ventured to answer the question: What does psychoanalysis have to offer individuals, and the collective, as a way of seeing and being with the reality of what is? Taking up these questions in such a time as this, feels, perhaps inevitably, unsafe. Sometimes it can feel as if there is a silent and unspoken mandate to ensure safety at all costs when we seek to find a spirit of the depth's response to the spirit of the times...
March 14, 2024: Journal of Analytical Psychology
https://read.qxmd.com/read/38452945/the-smac-mimetic-gdc-0152-is-a-direct-abcb1-atpase-activity-modulator-and-birc5-expression-suppressor-in-cancer-cells
#3
JOURNAL ARTICLE
I-Li Lin, Yu-Ting Lin, Yung-Chieh Chang, Sree Karani Kondapuram, Kai-Hsuan Lin, Pin-Chen Chen, Chung-Ying Kuo, Mohane Selvaraj Coumar, Chun Hei Antonio Cheung
Upregulation of the multidrug efflux pump ABCB1/MDR1 (P-gp) and the anti-apoptotic protein BIRC5/Survivin promotes multidrug resistance in various human cancers. GDC-0152 is a DIABLO/SMAC mimetic currently being tested in patients with solid tumors. However, it is still unclear whether GDC-0152 is therapeutically applicable for patients with ABCB1-overexpressing multidrug-resistant tumors, and the molecular mechanism of action of GDC-0152 in cancer cells is still incompletely understood. In this study, we found that the potency of GDC-0152 is unaffected by the expression of ABCB1 in cancer cells...
March 5, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38452244/integrative-multi-modal-metabolomics-to-early-predict-cognitive-decline-among-amyloid-positive-community-dwelling-older-adults
#4
JOURNAL ARTICLE
Marie Tremblay-Franco, Cécile Canlet, Audrey Carriere, Jean Nakhle, Anne Galinier, Jean-Charles Portais, Armelle Yart, Cédric Dray, Wan-Hsuan Lu, Justine Bertrand Michel, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Julien Delrieu, Philippe de Souto Barreto, Luc Pénicaud, Louis Casteilla, Isabelle Ader
Alzheimer's disease is strongly linked to metabolic abnormalities. We aimed to distinguish amyloid-positive people who progressed to cognitive decline from those who remained cognitively intact. We performed untargeted metabolomics of blood samples from amyloid-positive individuals, before any sign of cognitive decline, to distinguish individuals who progressed to cognitive decline from those who remained cognitively intact. A plasma-derived metabolite signature was developed from Supercritical Fluid chromatography coupled with high-resolution mass spectrometry (SFC-HRMS) and nuclear magnetic resonance (NMR) metabolomics...
March 7, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/38414488/revisiting-multi-omics-based-predictors-of-the-plasma-triglyceride-response-to-an-omega-3-fatty-acid-supplementation
#5
JOURNAL ARTICLE
Josiane Morin-Bernier, Juan de Toro-Martín, Valentin Barbe, Rodrigo San-Cristobal, Simone Lemieux, Iwona Rudkowska, Patrick Couture, Olivier Barbier, Marie-Claude Vohl
BACKGROUND: The aim of the present study was to identify the metabolomic signature of responders and non-responders to an omega-3 fatty acid (n-3 FA) supplementation, and to test the ability of a multi-omics classifier combining genomic, lipidomic, and metabolomic features to discriminate plasma triglyceride (TG) response phenotypes. METHODS: A total of 208 participants of the Fatty Acid Sensor (FAS). Study took 5 g per day of fish oil, providing 1.9-2.2 g eicosapentaenoic acid (EPA) and 1...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38373985/profiles-of-subgingival-microbiomes-and-gingival-crevicular-metabolic-signatures-in-patients-with-amnestic-mild-cognitive-impairment-and-alzheimer-s-disease
#6
JOURNAL ARTICLE
Che Qiu, Wei Zhou, Hui Shen, Jintao Wang, Ran Tang, Tao Wang, Xinyi Xie, Bo Hong, Rujing Ren, Gang Wang, Zhongchen Song
BACKGROUND: The relationship between periodontitis and Alzheimer's disease (AD) has attracted more attention recently, whereas profiles of subgingival microbiomes and gingival crevicular fluid (GCF) metabolic signatures in AD patients have rarely been characterized; thus, little evidence exists to support the oral-brain axis hypothesis. Therefore, our study aimed to characterize both the microbial community of subgingival plaque and the metabolomic profiles of GCF in patients with AD and amnestic mild cognitive impairment (aMCI) for the first time...
February 19, 2024: Alzheimer's Research & Therapy
https://read.qxmd.com/read/38291026/molecular-mechanisms-underlying-the-birc6-mediated-regulation-of-apoptosis-and-autophagy
#7
JOURNAL ARTICLE
Shuo-Shuo Liu, Tian-Xia Jiang, Fan Bu, Ji-Lan Zhao, Guang-Fei Wang, Guo-Heng Yang, Jie-Yan Kong, Yun-Fan Qie, Pei Wen, Li-Bin Fan, Ning-Ning Li, Ning Gao, Xiao-Bo Qiu
Procaspase 9 is the initiator caspase for apoptosis, but how its levels and activities are maintained remains unclear. The gigantic Inhibitor-of-Apoptosis Protein BIRC6/BRUCE/Apollon inhibits both apoptosis and autophagy by promoting ubiquitylation of proapoptotic factors and the key autophagic protein LC3, respectively. Here we show that BIRC6 forms an anti-parallel U-shaped dimer with multiple previously unannotated domains, including a ubiquitin-like domain, and the proapoptotic factor Smac/DIABLO binds BIRC6 in the central cavity...
January 30, 2024: Nature Communications
https://read.qxmd.com/read/38275029/smac-mimetics-for-the-treatment-of-lung-carcinoma-present-development-and-future-prospects
#8
JOURNAL ARTICLE
Ruchi Pandey, Priya Bisht, Pranay Wal, Krishna Murti, V Ravichandiran, Nitesh Kumar
BACKGROUND: Uncontrolled cell growth and proliferation, which originate from lung tissue often lead to lung carcinoma and are more likely due to smoking as well as inhaled environmental toxins. It is widely recognized that tumour cells evade the ability of natural programmed death (apoptosis) and facilitates tumour progression and metastasis. Therefore investigating and targeting the apoptosis pathway is being utilized as one of the best approaches for decades. OBJECTIVE: This review describes the emergence of SMAC mimetic drugs as a treatment approach, its possibilities to synergize the response along with current limitations as well as future perspective therapy for lung cancer...
January 23, 2024: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/38030916/exploring-soil-bacterial-diversity-in-relation-to-edaphic-physicochemical-properties-of-high-altitude-wetlands-from-argentine-puna
#9
JOURNAL ARTICLE
Estela Cecilia Mlewski, Luis A Saona, Flavia Jaquelina Boidi, M Fernanda Chiappero, María Victoria Vaieretti, Mariana Soria, María Eugenia Farías, Andrea E Izquierdo
High Andean wetlands, particularly those known as vegas or bofedales, are essential conservation ecosystems due to their significant contribution to ecosystem services. The soil microbial communities in these ecosystems play a crucial role in fundamental processes such as decomposition and nutrient cycling, sustaining life in the region. However, at present, these microbial communities are poorly understood. In order to contribute to this knowledge, we aimed to characterize and compare the microbial communities from soils of seven Argentine Puna vegas and to analyze their association with soil physicochemical characteristics...
November 30, 2023: Microbial Ecology
https://read.qxmd.com/read/38028548/machine-learning-combining-multi-omics-data-and-network-algorithms-identifies-adrenocortical-carcinoma-prognostic-biomarkers
#10
JOURNAL ARTICLE
Roberto Martin-Hernandez, Sergio Espeso-Gil, Clara Domingo, Pablo Latorre, Sergi Hervas, Jose Ramon Hernandez Mora, Ekaterina Kotelnikova
Background: Rare endocrine cancers such as Adrenocortical Carcinoma (ACC) present a serious diagnostic and prognostication challenge. The knowledge about ACC pathogenesis is incomplete, and patients have limited therapeutic options. Identification of molecular drivers and effective biomarkers is required for timely diagnosis of the disease and stratify patients to offer the most beneficial treatments. In this study we demonstrate how machine learning methods integrating multi-omics data, in combination with system biology tools, can contribute to the identification of new prognostic biomarkers for ACC...
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/37859957/cross-species-analysis-of-differential-transcript-usage-in-humans-and-chickens-with-fatty-liver-disease
#11
JOURNAL ARTICLE
Kaj Chokeshaiusaha, Thanida Sananmuang, Denis Puthier, Catherine Nguyen
BACKGROUND AND AIM: Fatty liver disease is a common condition, characterized by excess fat accumulation in the liver. It can contribute to more severe liver-related health issues, making it a critical concern in avian and human medicine. Apart from modifying the gene expression of liver cells, the disease also alters the expression of specific transcript isoforms, which might serve as new biological markers for both species. This study aimed to identify cross-species genes displaying differential expressions in their transcript isoforms in humans and chickens with fatty liver disease...
September 2023: Veterinary World
https://read.qxmd.com/read/37818865/vibrio-parahaemolyticus-thermostable-direct-haemolysin-induces-non-classical-programmed-cell-death-despite-caspase-activation
#12
JOURNAL ARTICLE
Pratima Verma, Aakanksha Chauhan, Reena Thakur, Kusum Lata, Arpita Sharma, Kausik Chattopadhyay, Arunika Mukhopadhaya
Thermostable direct haemolysin (TDH) is the key virulence factor secreted by the human gastroenteric bacterial pathogen Vibrio parahaemolyticus. TDH is a membrane-damaging pore-forming toxin. It evokes potent cytotoxicity, the mechanism of which still remains under-explored. Here, we have elucidated the mechanistic details of cell death response elicited by TDH. Employing Caco-2 intestinal epithelial cells and THP-1 monocytic cells, we show that TDH induces some of the hallmark features of apoptosis-like programmed cell death...
October 11, 2023: Molecular Microbiology
https://read.qxmd.com/read/37806074/gut-microbiota-alterations-induced-by-intensive-chemotherapy-in-acute-myeloid-leukaemia-patients-are-associated-with-gut-barrier-dysfunction-and-body-weight-loss
#13
JOURNAL ARTICLE
Sarah A Pötgens, Sophie Lecop, Violaine Havelange, Fuyong Li, Audrey M Neyrinck, Nathalie Neveux, Johan Maertens, Jens Walter, Hélène Schoemans, Nathalie M Delzenne, Laure B Bindels
BACKGROUND & AIMS: Acute myeloid leukaemia (AML) chemotherapy has been reported to impact gut microbiota composition. In this study, we investigated using a multi -omics strategy the changes in the gut microbiome induced by AML intense therapy and their association with gut barrier function and cachectic hallmarks. METHODS: 10 AML patients, allocated to standard induction chemotherapy (SIC), were recruited. Samples and data were collected before any therapeutic intervention (T0), at the end of the SIC (T1) and at discharge (T4)...
September 25, 2023: Clinical Nutrition
https://read.qxmd.com/read/37775061/new-insights-into-the-cytotoxic-effects-of-thymus-vulgaris-essential-oil-on-the-human-triple-negative-breast-cancer-cell-line-mda-mb-231
#14
JOURNAL ARTICLE
Serena Benedetti, Maria Gemma Nasoni, Francesca Luchetti, Francesco Palma
Essential oils (EOs) are natural products that have gained wide interest due to their biological activities and anticancer properties through various mechanisms. The present study aimed to test the cytotoxicity of Thymus vulgaris L. (thyme) EO of Italian origin, rich in thymol (49.6%) and p-cymene (18.8%), towards the triple-negative breast cancer cell line MDA-MB-231 and to investigate the biochemical mechanisms underlying its antitumor activity. Thyme EO reduced cancer cell viability in a dose-dependent manner after 24 h treatment, with an IC50 value equal to 75...
September 27, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/37757955/goat-mammary-gland-metabolism-an-integrated-omics-analysis-to-unravel-seasonal-weight-loss-tolerance
#15
JOURNAL ARTICLE
David Miguel Ribeiro, Mariana Palma, José Salvado, Lorenzo E Hernández-Castellano, Juan Capote, Noemí Castro, Anastasio Argüello, Manolis Matzapetakis, Susana S Araújo, André Martinho de Almeida
Seasonal weight loss (SWL), is a major limitation to animal production. In the Canary Islands, there are two dairy goat breeds with different levels of tolerance to SWL: Majorera (tolerant) and Palmera (susceptible). Our team has studied the response of these breeds to SWL using different Omics. The objective of this study was to integrate such results in a data driven approach and using dedicated tools, namely the DIABLO software. The outputs of our analysis mainly separate unrestricted from restricted goats...
September 25, 2023: Journal of Proteomics
https://read.qxmd.com/read/37719083/application-note-tdbasedufe-and-tdbasedufeadv-bioconductor-packages-to-perform-tensor-decomposition-based-unsupervised-feature-extraction
#16
JOURNAL ARTICLE
Y-H Taguchi, Turki Turki
MOTIVATION: Tensor decomposition (TD)-based unsupervised feature extraction (FE) has proven effective for a wide range of bioinformatics applications ranging from biomarker identification to the identification of disease-causing genes and drug repositioning. However, TD-based unsupervised FE failed to gain widespread acceptance due to the lack of user-friendly tools for non-experts. RESULTS: We developed two bioconductor packages-TDbasedUFE and TDbasedUFEadv-that enable researchers unfamiliar with TD to utilize TD-based unsupervised FE...
2023: Frontiers in artificial intelligence
https://read.qxmd.com/read/37711175/dual-targeting-peptides-pmo-a-mimetic-to-the-pro-apoptotic-protein-smac-diablo-for-selective-activation-of-apoptosis-in-cancer-cells
#17
JOURNAL ARTICLE
Eros Di Giorgio, Annalisa Ferino, Weizhe Huang, Sigrid Simonetti, Luigi Xodo, Rossella De Marco
The refractoriness of tumor cells to apoptosis represents the main mechanism of resistance to chemotherapy. Smac/DIABLO mimetics proved to be effective in overcoming cancer-acquired resistance to apoptosis as a consequence of overexpression of the anti-apoptotic proteins XIAP, cIAP1, and cIAP2. In this work, we describe a dual-targeting peptide capable of selectively activating apoptosis in cancer cells. The complex consists of a fluorescent periodic mesoporous organosilica nanoparticle that carries the short sequences of Smac/DIABLO bound to the αvβ3-integrin ligand...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37691464/canyon-diablo-lonsdaleite-is-a-nanocomposite-containing-c-h-stacking-disordered-diamond-and-diaphite
#18
JOURNAL ARTICLE
Péter Németh, Laurence A J Garvie, Christoph G Salzmann
In 1967, a diamond polymorph was reported from hard, diamond-like grains of the Canyon Diablo iron meteorite and named lonsdaleite. This mineral was defined and identified by powder X-ray diffraction (XRD) features that were indexed with a hexagonal unit cell. Since 1967, several natural and synthetic diamond-like materials with XRD data matching lonsdaleite have been reported and the name lonsdaleite was used interchangeably with hexagonal diamond. Its hexagonal structure was speculated to lead to physical properties superior to cubic diamond, and as such has stimulated attempts to synthesize lonsdaleite...
October 30, 2023: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://read.qxmd.com/read/37594275/-ehrlichia-notch-signaling-induction-promotes-xiap-stability-and-inhibits-apoptosis
#19
JOURNAL ARTICLE
LaNisha L Patterson, Caitlan D Byerly, Regina Solomon, Nicholas Pittner, Duc Cuong Bui, Jignesh Patel, Jere W McBride
Ehrlichia chaffeensis has evolved multiple strategies to evade innate defenses of the mononuclear phagocyte. Recently, we reported the E. chaffeensis tandem repeat protein (TRP)120 effector functions as a Notch ligand mimetic and a ubiquitin ligase that degrades the nuclear tumor suppressor, F-box and WD repeat domain-containing 7, a negative regulator of Notch. The Notch intracellular domain (NICD) is known to inhibit apoptosis primarily by interacting with X-linked inhibitor of apoptosis <u>p</u>rotein (XIAP) to prevent degradation...
August 18, 2023: Infection and Immunity
https://read.qxmd.com/read/37559720/molecular-signature-associated-with-cladribine-treatment-in-patients-with-multiple-sclerosis
#20
JOURNAL ARTICLE
Nicolas Fissolo, Laura Calvo-Barreiro, Herena Eixarch, Ursula Boschert, Luisa M Villar, Lucienne Costa-Frossard, Mireia Ferrer, Alex Sanchez, Eva Borràs, Eduard Sabidó, Carmen Espejo, Xavier Montalban, Manuel Comabella
INTRODUCTION: Little is known about the molecular profiling associated with the effect of cladribine in patients with multiple sclerosis (MS). Here, we aimed first to characterize the transcriptomic and proteomic profiles induced by cladribine in blood cells, and second to identify potential treatment response biomarkers to cladribine in patients with MS. METHODS: Gene, protein and microRNA (miRNA) expression profiles were determined by microarrays (genes, miRNAs) and mass spectrometry (proteins) in peripheral blood mononuclear cells (PBMCs) from MS patients after in vitro treatment with cladribine in its active and inactive forms...
2023: Frontiers in Immunology
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