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https://www.readbyqxmd.com/read/29772403/theoretical-study-of-the-intermolecular-recognition-mechanism-between-survivin-and-substrate-based-on-conserved-binding-mode-analysis
#1
Chao Wu, Liguang Mao, Xie Huang, Weitao Fu, Xiong Cai, Yuepiao Cai, Liqun Shen, Xiaoxia Ye
Survivin is the smallest member of IAP (inhibitor of apoptosis protein) family, which plays important roles in both mitosis and apoptosis. It has become an attractive drug target due to its overexpression in many human cancers. Survivin has been proven to bind to Smac/DIABLO protein that indirectly inhibits apoptosis. Meanwhile, it is the key subunit of chromosome passenger complex (CPC) which bind to the N-terminal tail of phosphorylated histone H3T3ph during mitosis. Up to now, Survivin directly targeting inhibitor has yet to merge since the difficulty of disrupting the protein-protein interactions (PPIs) between Survivin and its substrate proteins...
May 8, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29690167/five-new-cave-dwelling-species-of-hemirrhagus-simon-1903-araneae-theraphosidae-theraphosinae-with-notes-on-the-generic-distribution-and-novel-morphological-features
#2
Jorge I Mendoza, Oscar F Francke
The suborder Mygalomorphae is generally poorly represented in the cave faunas of the world. The genus Hemirrhagus is endemic to Mexico and has 22 described species. It is the only one with epigean, troglophile and troglobitic species. Lack of urticating setae, loss of eye pigmentation and ocular reduction are interpreted as evolutionary reversals related to their troglobitic habits. From five troglobitic species in the genus, only the male of Hemirrhagus stygius is known. Five new troglobitic species are described with both sexes: Hemirrhagus akheronteus sp...
April 12, 2018: Zootaxa
https://www.readbyqxmd.com/read/29624055/potential-isothiocyanate-release-remains-constant-across-biofumigant-seeding-rates
#3
T Doheny-Adams, C J Lilley, A Barker, S Ellis, R Wade, H J Atkinson, P E Urwin, K Redeker, S E Hartley
Biofumigation is an integrated pest management method involving the mulching of a glucosinolate containing cover crop into a field in order to generate toxic isothiocyanates, effective soil borne pest control compounds. Variation in biofumigation efficacy demonstrates a need to better understand the factors affecting pest control outcomes and develop best practice for biofumigant choice, growth conditions and mulching methods which allow the greatest potential isothiocyanate release. We measured the glucosinolate concentration of 6 different commercial varieties of three different biofumigant plant species: Brassica juncea (ISCI99, Vitasso, Scala) Raphanus sativus (Diablo, Bento) and Sinapis alba (Ida Gold)...
April 6, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29562492/smac-combined-with-ddp-can-inhibit-drug-resistance-of-ovarian-cancer-through-regulation-of-survivin-expression
#4
Qi Chen, Hong Zhang
Ovarian cancer has the highest mortality rate among gynecological malignancies, presenting a major threat to women's life and health. It is essential to study the mechanisms of drug resistance to chemotherapy to identify ways to enhance drug-sensitivity. In recent years, many studies have shown that Smac/DIABLO is closely related to tumor drug resistance. Smac/DIABLO expression is markedly different between drug-resistant and chemo sensitive tumor cells. Up-regulation of Smac/DIABLO has been shown to increase tumor cell chemotherapy sensitivity...
February 28, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29538428/cardioprotection-of-tilianin-ameliorates-myocardial-ischemia-reperfusion-injury-role-of-the-apoptotic-signaling-pathway
#5
Cheng Zeng, Wen Jiang, Ruifang Zheng, Chenghui He, Jianguang Li, Jianguo Xing
Our previous research demonstrated that tilianin protects the myocardium in a myocardial ischemia reperfusion injury (MIRI) rat model and has prominent pharmacological potential as a cardiovascular drug. Our study aimed to investigate the molecular signaling implicated in the improvement of myocardial survival induced by tilianin, a flavonoid antioxidant. Tilianin (2.5, 5, and 10 mg/kg/d) or saline was orally administered to rats for 14 days. On the 15th day, ischemia was induced by ligating the left anterior descending artery for 45 min, followed by 4 h of reperfusion...
2018: PloS One
https://www.readbyqxmd.com/read/29530807/minocycline-an-antimicrobial-agent-attenuates-the-mitochondrial-dependent-cell-death-and-stabilizes-the-expression-of-hif-1%C3%AE-in-spinal-cord-injury
#6
Guolei Zhang, Junpu Zha, Junchuan Liu, Jun Di
One of the crucial mechanisms following spinal cord injury is mitochondria associated cell death. Minocycline, an anti-inflammatory drug is well known to impede the mitochondrial cell death. However, there has been no study on the effect of minocycline linking FAS-mediated cell death and hypoxia inducible factor (HIF-1α), the targets involved in mitochondrial cell death. Male Sprague Drawley rats (N = 18, divided into three groups) were subjected to traumatic spinal cord injury and were injected with minocycline (n = 6) (90 mg/kg, and later 45 mg/kg dose two times a day (every 12 h)...
March 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29472100/diablo-a-double-edged-sword-in-cancer
#7
Jack L Arbiser
No abstract text is available yet for this article.
March 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29440708/differential-role-of-fl-bid-and-t-bid-during-verotoxin-1-induced-apoptosis-in-burkitt-s-lymphoma-cells
#8
Justine Debernardi, Emilie Hollville, Marc Lipinski, Joëlle Wiels, Aude Robert
The globotriaosylceramide Gb3 is a glycosphingolipid expressed on a subpopulation of germinal center B lymphocytes which has been recognized as the B cell differentiation antigen CD77. Among tumoral cell types, Gb3/CD77 is strongly expressed in Burkitt's lymphoma (BL) cells as well as other solid tumors including breast, testicular and ovarian carcinomas. One known ligand of Gb3/CD77 is Verotoxin-1 (VT-1), a Shiga toxin produced in specific E. coli strains. Previously, we have reported that in BL cells, VT-1 induces apoptosis via a caspase-dependent and mitochondria-dependent pathway...
May 2018: Oncogene
https://www.readbyqxmd.com/read/29434929/vernodalol-mediates-antitumor-effects-in-acute-promyelocytic-leukemia-cells
#9
Wenjun Wu, Xiaoyan Han, Cai Wu, Guoqing Wei, Gaofeng Zheng, Yi Li, Yang Yang, Li Yang, Donghua He, Yi Zhao, Zhen Cai
Acute promyelocytic leukemia (APL) remains a challenge to cure due to the side effects of cytotoxic chemotherapy and drug resistance. The present study demonstrated that vernodalol, an active compound isolated from Centratherum anthelminticum , suppresses APL cell proliferation and induces cell cycle arrest in the G2/M phase through the upregulation of p21 and cell division cycle 25. In addition, vernodalol induced cellular apoptosis via the mitochondrial pathway as observed by the cleavage of caspase-9 as well as the release of cytochrome c and Smac/DIABLO into the cytosol...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29420562/induction-of-apoptosis-by-pinostrobin-in-human-cervical-cancer-cells-possible-mechanism-of-action
#10
Alka Jaudan, Sapna Sharma, Sri Nurestri Abd Malek, Aparna Dixit
Pinostrobin (PN) is a naturally occurring dietary bioflavonoid, found in various medicinal herbs/plants. Though anti-cancer potential of many such similar constituents has been demonstrated, critical biochemical targets and exact mechanism for their apoptosis-inducing actions have not been fully elucidated. The present study was aimed to investigate if PN induced apoptosis in cervical cancer cells (HeLa) of human origin. It is demonstrated that PN at increasing dose effectivity reduced the cell viability as well as GSH and NO2- levels...
2018: PloS One
https://www.readbyqxmd.com/read/29396267/a-new-role-for-the-mitochondrial-pro-apoptotic-protein-smac-diablo-in-phospholipid-synthesis-associated-with-tumorigenesis
#11
Avijit Paul, Yakov Krelin, Tasleem Arif, Rina Jeger, Varda Shoshan-Barmatz
The mitochondrial pro-apoptotic protein SMAC/Diablo participates in apoptosis by negatively regulating IAPs and activating caspases, thus encouraging apoptosis. Unexpectedly, we found that SMAC/Diablo is overexpressed in cancer. This paradox was addressed here by silencing SMAC/Diablo expression using specific siRNA (si-hSMAC). In cancer cell lines and subcutaneous lung cancer xenografts in mice, such silencing reduced cell and tumor growth. Immunohistochemistry and electron microscopy of the si-hSMAC-treated residual tumor demonstrated morphological changes, including cell differentiation and reorganization into glandular/alveoli-like structures and elimination of lamellar bodies, surfactant-producing organs...
March 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29285267/a-molecular-signature-of-lung-cancer-potential-biomarkers-for-adenocarcinoma-and-squamous-cell-carcinoma
#12
Varda Shoshan-Barmatz, Yael Bishitz, Avijit Paul, Yakov Krelin, Itay Nakdimon, Nir Peled, Avia Lavon, Elina Rudoy-Zilberman, Yael Refaely
Adenocarcinoma (AC) and squamous cell carcinoma (SCC), sub-types of non-small cell lung cancer (NSCLC), both present unique features at the genome, epigenome, transcriptome and proteome levels, as well as shared clinical and histopathological characteristics, but differ in terms of treatment. To ensure proper treatment, one must be able to distinguish between these sub-types. Here, we identify novel biomarker proteins in NSCLC, allowing for distinguishing between the AC and SCC sub-types. Proteomics analysis distinguished between healthy and tumor tissues, with the expression level of 1,494 proteins being altered, 378 of which showed a ≥|100|-fold change...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29248972/pharmacological-targeting-of-hsp90-with-17-aag-induces-apoptosis-of-myogenic-cells-through-activation-of-the-intrinsic-pathway
#13
Akira Wagatsuma, Yuzo Takayama, Takayuki Hoshino, Masataka Shiozuka, Shigeru Yamada, Ryoichi Matsuda, Kunihiko Mabuchi
We have shown that pharmacological inhibition of HSP90 ATPase activity induces apoptosis of myoblasts during their differentiation. However, the signaling pathways remain not fully characterized. We report that pharmacological targeting of HSP90 with 17-AAG activates the intrinsic pathway including caspase-dependent and caspase-independent pathways. 17-AAG induces the typical apoptotic phenotypes including PARP cleavage, chromatin condensation, and nuclear fragmentation with mitochondrial release of cytochrome c, Smac/DIABLO, procaspase-9 processing, and caspase-3 activation...
December 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29240261/mitochondrial-dysfunction-rad51-and-ku80-proteolysis-promote-apoptotic-effects-of-dinaciclib-in-bcl-xl-silenced-cells
#14
Daniel R Premkumar, Esther P Jane, Swetha Thambireddy, Philip A Sutera, Jonathon M Cavaleri, Ian F Pollack
In the present study, we investigated the effect of CDK inhibitors (ribociclib, palbociclib, seliciclib, AZD5438, and dinaciclib) on malignant human glioma cells for cell viability, apoptosis, oxidative stress, and mitochondrial function using various assays. None of the CDK inhibitors induced cell death at a clinically relevant concentration. However, low nanomolar concentrations of dinaciclib showed higher cytotoxic activity against Bcl-xL silenced cells in a time- and concentration-dependent manner. This effect was not seen with other CDK inhibitors...
April 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29236891/high-expression-of-xiap-and-bcl-2-may-inhibit-programmed-cell-death-in-glioblastomas
#15
Daniela Pretti da Cunha Tirapelli, Isis Lacrose Lustosa, Sarah Bomfim Menezes, Indira Maynart Franco, Andressa Romualdo Rodrigues, Fernanda Maris Peria, Alexandre Magno da Nóbrega Marinho, Luciano Neder Serafini, Carlos Gilberto Carlotti, Luís Fernando Tirapelli
Glioblastoma (GBM) is the most malignant glioma and represents 29% of all brain tumors. Tumorigenesis is intimately connected with characteristics acquired in the physiologic pathway of cellular death. OBJECTIVE: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to the apoptosis pathway were evaluated in 30 samples of glioblastoma. METHODS: The gene expression was evaluated in 30 glioblastomas (WHO grade IV) and compared to 10 white matter control samples with real-time PCR...
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29192254/effect-of-src-kinase-inhibition-on-cytochrome-c-smac-diablo-and-apoptosis-inducing-factor-aif-following-cerebral-hypoxia-ischemia-in-newborn-piglets
#16
Panagiotis Kratimenos, Ioannis Koutroulis, Beamon Agarwal, Stamatios Theocharis, Maria Delivoria-Papadopoulos
We have previously shown that cerebral Hypoxia-ischemia (HI) results in activation of Src kinase in the newborn piglet brain. We investigated the regulatory mechanism by which the pre-apoptotic proteins translocate from mitochondria to the cytosol during HI through the Src kinase. Newborn piglets were divided into 3 groups (n = 5/group): normoxic (Nx), HI and HI pre-treated with Src kinase inhibitor PP2 (PP2 + HI). Brain tissue HI was verified by neuropathological analysis and by Adenosine Triphosphate (ATP) and Phosphocreatine (PCr) levels...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29154934/cephalostatin-1-analogues-activate-apoptosis-via-the-endoplasmic-reticulum-stress-signaling-pathway
#17
Lubna H Tahtamouni, Mansour M Nawasreh, Zainab A Al-Mazaydeh, Rema A Al-Khateeb, Reem N Abdellatif, Randa M Bawadi, James R Bamburg, Salem R Yasin
The current study was conducted to compare the cytotoxicity of two stereospecific cephalostatin 1 analogues (CAs) against several human normal cell types and cancer cell lines and to determine their cytotoxic mechanism. Both CA analogues induced apoptosis and were cytotoxic with 50% growth inhibition (GI50 ) at ~1µM or less in six human cancer cell lines but neither analogue at 10µM killed more than 14% of any of three types of normal human cells suggesting their cytotoxicity is cancer-specific. CA treatment inhibited clonogenic tumor growth and activated caspase 3 and 9 but not caspase 8...
January 5, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29067612/sources-of-sulphate-minerals-in-limestone-cave-a-possible-evidence-of-anthropogenic-activity-a-case-study-in-%C3%A4-rna-jama-cave-slovenia
#18
Simona Jarc, Miloš Miler, Stanka Šebela, Nina Zupančič
In the caves, the formation of cave minerals is a consequence of a variety of chemical reactions, some of them also due to human activity. There are many caves in Slovenia, but sulphate minerals are not very often reported and analysed. In this study, the presence of sulphate minerals is detected by SEM/EDS analysis of speleothems from Črna Jama, a cave near Kočevje (southern Slovenia). The cave is characterised by its dark, almost black colour on cave walls, floor and speleothems. Anthropogenic influence in the cave is still visible, including the remains of a fireplace, some inscriptions on the walls and wooden containers...
December 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28947709/the-first-report-of-diablo-in-megalobrama-amblycephala-characterization-phylogenetic-analysis-functional-annotation-and-expression
#19
Ngoc Tuan Tran, Ivan Jakovlić, Wei-Min Wang
Smac/DIABLO gene is essential for the apoptosis mechanism in mammals. This study is the first report of the Megalobrama amblycephala (ma) diablo gene, and the first report of the tertiary structure of a Diablo polypeptide in fish. Madiablo is 1540-bp long with an open reading frame of 792 bp, encoding a putative protein of 263 amino acids with a molecular weight of 29.2 kDa. Phylogenetic analysis indicates that it is closely related to the zebrafish Diablo-a homologue. It also indicates the existence of two diablo copies (a and b) in teleosts; apart fromthe Percomorpha group,where diablo-b has been lost, but diablo-a had undergone an independent duplication...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28807721/selenopheno-quinolinones-and-coumarins-promote-cancer-cell-apoptosis-by-ros-depletion-and-caspase-7-activation
#20
Ilona Domracheva, Iveta Kanepe-Lapsa, Ludmila Jackevica, Jelena Vasiljeva, Pavel Arsenyan
AIM: This study was designed to investigate the mechanism underlying cancer cell apoptosis caused by selenophenoquinolinones and coumarins. MATERIALS AND METHODS: Twelve derivatives were studied according to their ability to suppress the proliferation of cancer cells in vitro (i.e., HepG2, MH-22A, MCF-7), induce cell apoptosis, modulate cellular antioxidant enzyme system activities (i.e., SOD, GPx, TrxR), influence the level of ROS, and modulate caspase activity...
October 1, 2017: Life Sciences
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