Marie Tremblay-Franco, Cécile Canlet, Audrey Carriere, Jean Nakhle, Anne Galinier, Jean-Charles Portais, Armelle Yart, Cédric Dray, Wan-Hsuan Lu, Justine Bertrand Michel, Sophie Guyonnet, Yves Rolland, Bruno Vellas, Julien Delrieu, Philippe de Souto Barreto, Luc Pénicaud, Louis Casteilla, Isabelle Ader
Alzheimer's disease is strongly linked to metabolic abnormalities. We aimed to distinguish amyloid-positive people who progressed to cognitive decline from those who remained cognitively intact. We performed untargeted metabolomics of blood samples from amyloid-positive individuals, before any sign of cognitive decline, to distinguish individuals who progressed to cognitive decline from those who remained cognitively intact. A plasma-derived metabolite signature was developed from Supercritical Fluid chromatography coupled with high-resolution mass spectrometry (SFC-HRMS) and nuclear magnetic resonance (NMR) metabolomics...
March 7, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences