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Alessia Alunno, Maria Comasia Leone, Roberto Giacomelli, Roberto Gerli, Francesco Carubbi
Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease mainly affecting exocrine glands and leading to impaired secretory function. The clinical picture is dominated by signs and symptoms of mucosal dryness and the course of the disease is mild and indolent in the majority of cases. However, a subgroup of patients can also experience extraglandular manifestations that worsen the disease prognosis. pSS patients are consistently found to have a higher risk of developing non-Hodgkin lymphoma (NHL) compared with patients with other autimmune disorders and to the general population...
2018: Frontiers in Medicine
B Oter-López, M Llamas-Velasco, J Sánchez-Pérez, E Dauden
BACKGROUND: The induction of antinuclear antibodies (ANA) and the onset of autoimmune diseases have been reported after treatment with tumor necrosis factor (TNF) inhibitors, though controversy persists. OBJECTIVES: To determine the frequency of onset of autoimmune diseases and of the appearance of autoantibodies in psoriasis patients administered TNF inhibitors (adalimumab and etanercept) subcutaneously and to correlate this with the effectiveness of treatment, adverse effects, and the order of use of TNF inhibitors...
June 2017: Actas Dermo-sifiliográficas
G A Scardina, A Ruggieri, P Messina
BACKGROUND: Oral lichen planus is an inflammatory chronic disease with an autimmune pathogenesis and unknown etiology that affects oral mucosa, with or without the involvement of the skin and other mucous membranes. The principal histological characteristics are the degeneration of the basal cell layer and the abnormal infiltration of inflammatory cells into the subepithelial layer of connective tissue. OBJECTIVES: This study is aimed to appraise if lingual lichen planus (LLP) is sustained by alteration of the oral microcirculation and if this abnormal vascularisation increases the degeneration of basal keratinocytes and the disruption of the basement membrane...
October 2009: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
Guillaume Hoeffel, Anne-Claire Ripoche, Diana Matheoud, Michelina Nascimbeni, Nicolas Escriou, Pierre Lebon, Farhad Heshmati, Jean-Gérard Guillet, Monique Gannagé, Sophie Caillat-Zucman, Nicoletta Casartelli, Olivier Schwartz, Henri De la Salle, Daniel Hanau, Anne Hosmalin, Concepción Marañón
Crosspresentation is a specialized function of myeloid dendritic cells (mDCs), allowing them to induce CD8+ T cell responses against exogenous antigens that are not directly produced in their cytotosol. Human plasmacytoid DCs (pDCs) are not considered so far as able to perform crosspresentation. We showed here that purified human pDCs crosspresented vaccinal lipopeptides and HIV-1 antigens from apoptotic cells to specific CD8+ T lymphocytes. Apoptotic debris were internalized by phagocytosis and the lipopeptide LPPol reached nonacidic endosomes...
September 2007: Immunity
J Sudendey, E Halle, A Moter, L Morawietz, H Olze
INTRODUCTION: Neoplasms, autimmune disorders and infectious diseases as differential diagnoses of cervical lymphadenopathies also require the consideration of rare causes. CASE REPORT: A 25-year-old patient presented for further diagnosis and treatment of a colliquating, high febrile cervical lymphadenopathy. The patient from Thailand who had been living in Germany for 8 years reported she worked as rice farmer during the 1980s. Examination showed a vast physical condition with severe weight loss, joint- and swallowing aches which did not respond to high doses of parenteral antibiotic treatment...
April 2007: Laryngo- Rhino- Otologie
K P Sengupta, S K Biswas, M Bose, A K Banerjee
No abstract text is available yet for this article.
September 1967: Indian Journal of Medical Sciences
F Puppo, G Di Benedetto, A Barabino, A M Soldà, C Priolo, F Indiveri
No abstract text is available yet for this article.
April 15, 1977: Bollettino Della Società Italiana di Biologia Sperimentale
R M Brugues, J L Vives-Corrons, C Rozman, J M Jou, J L Aguilar, F Cardellach, A Urbano, E Feliu
The hemophagocytosis or the process of ingestion of blood cells by phagocytes and macrophages of the mononuclear phagocytic system (MFS), is a phenomenon that rarely could be observed in the morphological examination of the bone marrow aspirate. Occasionally it is present in certain pathologic conditions such as, malignant histiocitosis, autimmune hemolytic anemia, or some chronic inflammatory diseases. The capacity of ingestion is not an exlusive property of the phagocytes and macrophages of the MFS, so that different neoplastic cells can show it too...
December 15, 1979: Medicina Clínica
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