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https://www.readbyqxmd.com/read/27864610/the-monorail-technique-to-overcome-difficult-anatomical-course-during-implantation-of-central-venous-port-via-the-left-internal-jugular-vein
#1
Eu Hyun Kim, Jung Suk Oh, Ho Jong Chun, Hae Giu Lee, Byung Gil Choi
PURPOSE: The study aimed to introduce a monorail technique to overcome difficult anatomical course via left internal jugular vein in implantable port insertion. METHODS: From 2007 to 2016, a total of 9346 patients were referred for implantable port insertion in our interventional unit, among which 79 cases were requested to insert on the left side. Our monorail technique was applied only when the technical challenge of the catheter tip entering the azygos vein instead of the superior vena cava occurred (n = 7)...
November 18, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27518457/development-of-a-novel-l-sulpiride-loaded-quaternary-microcapsule-effect-of-tpgs-as-an-absorption-enhancer-on-physicochemical-characterization-and-oral-bioavailability
#2
Dong Shik Kim, Dong Wuk Kim, Kyeong Soo Kim, Jong Seo Choi, Youn Gee Seo, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Sung Giu Jin, Han-Gon Choi
The aim of this study was to assess the effect of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on the physicochemical characterization and oral bioavailability of a novel l-sulpiride-loaded quaternary microcapsule (QMC). The effect of carriers on drug solubility was investigated. Among the carriers tested, polyvinyl pyrrolidone (PVP), sodium lauryl sulphate (SLS) and TPGS were selected as polymer, surfactant and absorption enhancer, respectively, due to their high drug solubility. Using the solvent evaporation method, numerous QMCs with different ratios of l-sulpiride, PVP, SLS and TPGS were prepared, and their physicochemical properties, solubility and release were evaluated...
November 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27451362/development-of-novel-prasugrel-base-microsphere-loaded-tablet-with-enhanced-stability-physicochemical-characterization-and-in-vivo-evaluation-in-beagle-dogs
#3
Kyeong Soo Kim, Jin Cheul Kim, Sung Giu Jin, Dong Wuk Kim, Dong Shik Kim, Chul Soon Yong, Jong Oh Kim, Yu Seok Youn, Kyung Taek Oh, Jong Soo Woo, Han-Gon Choi
The objective of this study was to develop a novel prasugrel base microsphere-loaded tablet (PBMST) with enhanced stability as a bioequivalent to the commercial prasugrel hydrochloride-loaded tablet. Numerous prasugrel base-loaded microspheres were prepared with hydroxypropylmethyl cellulose (HPMC), colloidal silica and various acidifying agents using a spray-drying process, and the physicochemical properties, solubility and stability were investigated. The PBMSTs were prepared and their dissolution, pharmacokinetics in beagle dogs and stability were evaluated compared to commercial prasugrel hydrochloride-loaded tablets...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27397868/comparison-of-solvent-wetted-and-kneaded-l-sulpiride-loaded-solid-dispersions-powder-characterization-and-in-vivo-evaluation
#4
Dong Shik Kim, Jong Seo Choi, Dong Wuk Kim, Kyeong Soo Kim, Youn Gee Seo, Kwan Hyung Cho, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Soo-Jeong Lim, Sung Giu Jin, Han-Gon Choi
The purpose of this study was to compare the powder properties, solubility, dissolution and oral absorption of solvent-wetted (SWSD) and kneaded (KNSD) l-sulpiride-loaded solid dispersions. The SWSD and KNSD were prepared with silicon dioxide, sodium laurylsulfate and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) using a spray dryer and high shear mixer, respectively. Their powder properties, solubility, dissolution and oral absorption were assessed compared to l-sulpiride powder. The drug in SWSD was in the amorphous state; however, in KNSD, it existed in the crystalline state...
September 10, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27127576/transjugular-intrahepatic-portosystemic-shunt-occlusion-complicated-with-biliary-fistula-successfully-treated-with-a-stent-graft-a-case-report
#5
Eunyoung Kim, Sung Won Lee, Woo Hyeon Kim, Si Hyun Bae, Nam Ik Han, Jung Suk Oh, Ho Jong Chun, Hae Giu Lee
A 43-year-old man with liver cirrhosis received transjugular intrahepatic portosystemic shunt (TIPS) for the treatment of recurrent variceal bleeding and F3 esophageal varices. During routine follow up liver ultrasound examination, six months after the implantation, TIPS occlusion was suspected and TIPS revision was performed. During the revision, moderate to severe stenosis at the hepatic venous segment of the tract and a total occlusion at the parenchymal segment of TIPS tract near the portal vein with biliary-TIPS fistula were identified with a clear visualization of the common bile duct...
January 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27106527/effect-of-hm30181-mesylate-salt-loaded-microcapsules-on-the-oral-absorption-of-paclitaxel-as-a-novel-p-glycoprotein-inhibitor
#6
Jin Cheul Kim, Kyeong Soo Kim, Dong Shik Kim, Sung Giu Jin, Dong Wuk Kim, Yong Il Kim, Jae-Hyun Park, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Jong Soo Woo, Han-Gon Choi
The purpose of this study was to develop HM30181 mesylate salt (HM30181M)-loaded microcapsules as a novel P-glycoprotein inhibitor for enhancing the oral absorption of paclitaxel. The effect of various carriers including hydrophilic polymers and solvents on the solubility of HM30181M were evaluated. Among the hydrophilic polymers and solvents tested, HPMC and methylene chloride (and ethanol) provided the highest HM30181M solubility. Numerous HM30181M-loaded microcapsules were prepared with HPMC, silicon dioxide and acidifying agents using a spray-drying technique, and their solubility, dissolution and physicochemical properties were evaluated...
June 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27083204/a-side-hole-catheter-for-catheterization-of-a-difficult-internal-mammary-artery
#7
Jung Suk Oh, Byung Gil Choi, Ho Jong Chun, Hae Giu Lee
BACKGROUND: The internal mammary artery (IMA) can be a source of hemoptysis in patients with chronic lung disease. Intervention via the IMA can be a challenge due to anatomic variations and lead to excessive contrast use and radiation exposure. PURPOSE: To evaluate safety and efficiency of a new side-hole catheter for the catheterization of the IMA in patients with hemoptysis. MATERIAL AND METHODS: From January 2011 to August 2014, a total of 96 transarterial embolization procedures required exact evaluation of the IMA due to chronic lung disease involving the anterior thorax...
April 14, 2016: Acta Radiologica
https://www.readbyqxmd.com/read/26992922/effect-of-magnesium-carbonate-on-the-solubility-dissolution-and-oral-bioavailability-of-fenofibric-acid-powder-as-an-alkalising-solubilizer
#8
Kyeong Soo Kim, Jeong Hyun Kim, Sung Giu Jin, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Chul Soon Yong, Kwan Hyung Cho, Dong Xun Li, Jong Soo Woo, Han-Gon Choi
To investigate the possibility of developing a novel oral pharmaceutical product using fenofibric acid instead of choline fenofibrate, the powder properties, solubility, dissolution and pharmacokinetics in rats of fenofibrate, choline fenofibrate and fenofibric acid were compared. Furthermore, the effect of magnesium carbonate, an alkalising agent on the solubility, dissolution and oral bioavailability of fenofibric acid was assessed, a mixture of fenofibric acid and magnesium carbonate being prepared by simple blending at a weight ratio of 2/1...
April 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/26983932/novel-montelukast-sodium-loaded-stable-oral-suspension-bioequivalent-to-the-commercial-granules-in-rats
#9
Dong Wuk Kim, Young Hun Kim, Abid Mehmood Yousaf, Dong Shik Kim, Taek Kwan Kwon, Jung Hee Park, Yong Il Kim, Jae-Hyun Park, Sung Giu Jin, Kyung Soo Kim, Kwan Hyung Cho, Dong Xun Li, Jong Oh Kim, Chul Soon Yong, Jong Soo Woo, Han-Gon Choi
To develop a montelukast sodium-loaded stable oral suspension bioequivalent to the commercial granules in rats, several montelukast sodium-loaded suspensions were prepared with a suspending agent, stabilizers and anti-aggregation agents, and their stabilities were investigated by visually observing the sedimentation phenomenon and determining the concentration of the degradation product. Moreover, dissolution and pharmacokinetic studies of the optimized formulation were examined in rats compared to commercial montelukast sodium-loaded granules...
April 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/26960538/safety-of-gadobutrol-in-over-23-000-patients-the-gardian-study-a-global-multicentre-prospective-non-interventional-study
#10
Martin R Prince, Hae Giu Lee, Chang-Hee Lee, Sung Won Youn, In Ho Lee, Woong Yoon, Benqiang Yang, Haiping Wang, Jin Wang, Tiffany Ting-Fang Shih, Guo-Shu Huang, Jiing-Feng Lirng, Petra Palkowitsch
OBJECTIVES: To investigate the safety and tolerability of gadobutrol at the recommended dose in patients requiring contrast-enhanced magnetic resonance imaging/angiography (MRI/MRA) in the routine setting. METHODS: GARDIAN prospectively enrolled 23,708 patients undergoing routine gadobutrol-enhanced MRI/MRA for approved indications at 272 study centres in Europe, Asia, North America, and Africa and monitored for adverse events. RESULTS: Median gadobutrol dose was 0...
January 2017: European Radiology
https://www.readbyqxmd.com/read/26851354/influence-of-hydrophilic-polymers-on-functional-properties-and-wound-healing-efficacy-of-hydrocolloid-based-wound-dressings
#11
Sung Giu Jin, Abid Mehmood Yousaf, Kyeong Soo Kim, Dong Wuk Kim, Dong Shik Kim, Jin Ki Kim, Chul Soon Yong, Yu Seok Youn, Jong Oh Kim, Han-Gon Choi
The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base using a hot melting method. Additionally, numerous SIS/PIB-based HCDs were prepared with six hydrophilic polymers, and their wound dressing properties were assessed...
March 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26834471/novel-electrosprayed-nanospherules-for-enhanced-aqueous-solubility-and-oral-bioavailability-of-poorly-water-soluble-fenofibrate
#12
Abid Mehmood Yousaf, Omer Mustapha, Dong Wuk Kim, Dong Shik Kim, Kyeong Soo Kim, Sung Giu Jin, Chul Soon Yong, Yu Seok Youn, Yu-Kyoung Oh, Jong Oh Kim, Han-Gon Choi
PURPOSE: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate. METHODS: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP) and Labrafil(®) M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/26808984/correction-the-values-of-combined-and-sub-stratified-imaging-scores-with-ultrasonography-and-mammography-in-breast-cancer-subtypes
#13
Tsun-Hou Chang, Hsian-He Hsu, Yu-Ching Chou, Jyh-Cherng Yu, Giu-Cheng Hsu, Guo-Shu Huang, Guo-Shiou Liao
No abstract text is available yet for this article.
2016: PloS One
https://www.readbyqxmd.com/read/26743241/-efficacy-of-combination-antiviral-therapy-following-childbirth-in-pregnant-hbv-carriers-receiving-telbivudine-for-prevention-of-mother-to-child-transmission
#14
Jun-Feng Lu, Ya-Li Liu, Li-Na Ma, Zhen-Huan Cao, Zhi-Min He, Yi Jin, Shi-Bin Zhang, Xin-Yue Chen
OBJECTIVE: To observe the clinical efficacy of combination therapy with peg-IFNalpha and adefovir (CPIA) in women who were hepatfis B virus (HBV) carriers and had just given birth and received telbivudine (LdT) during pregnancy for prevention of mother-to-child transmission. METHODS: One-hundred-and-fifty third trimester-pregnant women who were HBV carriers with highly-viremic were treated with LdT until time of birth. After delivery, those women with alanine aminotransferase (ALT) level exceeding two times the upper limit of normal and HBV DNA level that had decreased more than 31 gIU/mL or hepatitis B e antigen (HBeAg) titer that had decreased more than 50% were switched to CPIA for 96 weeks...
November 2015: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/26689198/the-values-of-combined-and-sub-stratified-imaging-scores-with-ultrasonography-and-mammography-in-breast-cancer-subtypes
#15
Tsun-Hou Chang, Hsian-He Hsu, Yu-Ching Chou, Jyh-Cherng Yu, Giu-Cheng Hsu, Guo-Shu Huang, Guo-Shiou Liao
BACKGROUND AND OBJECTIVES: The Breast Imaging Reporting and Data System (BI-RADS) of Mammography (MG) and Ultrasonography (US) were equivalent to the "5-point score" and applied for combined and sub-stratified imaging assessments. This study evaluated the value of combined and sub-stratified imaging assessments with MG and US over breast cancer subtypes (BCS). MATERIALS AND METHODS: Medical records of 5,037 cases having imaging-guided core biopsy, performed from 2009 to 2012, were retrospectively reviewed...
2015: PloS One
https://www.readbyqxmd.com/read/26680857/gastrosplenic-fistula-complicated-in-a-patient-with-non-hodgkin-s-lymphoma
#16
Seong Eun Yang, Jong Youl Jin, Chi Won Song, Ji Chan Park, Jee In Lee, Wook Kim, Jeana Kim, Hae Giu Lee
Reported cases of gastrosplenic fistulas are extremely rare in the literature. Malignancy is the primary cause in 50% of patients, followed by perforated peptic ulcer (40%). Fistulas can cause spleen rupture and potential bleeding that threaten the life of the patient. Lymphoma is the most common cause of malignancy complicated with gastrosplenic fistula. Most gastrosplenic fistulae caused by lymphoma eventually close following chemotherapy, although splenectomy should be performed to avoid further complications...
April 2002: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/26657270/development-of-a-novel-sodium-fusidate-loaded-triple-polymer-hydrogel-wound-dressing-mechanical-properties-and-effects-on-wound-repair
#17
Sung Giu Jin, Kyeong Soo Kim, Dong Wuk Kim, Dong Shik Kim, Youn Gee Seo, Toe Gyung Go, Yu Seok Youn, Jong Oh Kim, Chul Soon Yong, Han-Gon Choi
To develop a novel sodium fusidate-loaded triple polymer hydrogel dressing (TPHD), numerious polyvinyl alcohol-based (PVA) hydrogel dressings were prepared with various hydrophilic polymers using the freeze-thaw method, and their hydrogel dressing properties were assessed. Among the hydrophilic polymers tested, sodium alginate (SA) improved the swelling capacity the most, and polyvinyl pyrrolidone (PVP) provided the greatest improvement in bioadhesive stength and mechanical properties. Thus, PVA based-TPHDs were prepared using different ratios of PVP:SA...
January 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26394193/novel-neomycin-sulfate-loaded-hydrogel-dressing-with-enhanced-physical-dressing-properties-and-wound-curing-effect
#18
Jong Seo Choi, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Chul Soon Yong, Kwan Hyung Cho, Yu Seok Youn, Sung Giu Jin, Han-Gon Choi
To develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD...
October 2016: Drug Delivery
https://www.readbyqxmd.com/read/26390913/breast-nonmass-enhancement-detected-with-mri-uility-and-lesion-characterization-with-second-look-ultrasonography
#19
Hsian-He Hsu, Tsun-Hou Chang, Yu-Ching Chou, Yi-Jen Peng, Kai-Hsiung Ko, Wei-Chou Chang, Yu-Pang Lin, Giu-Cheng Hsu, Jyh-Cherng Yu
The purpose of this study was to verify the utility of second-look ultrasonography (US) in evaluating nonmass enhancement (NME) lesions detected on breast magnetic resonance imaging (MRI) by analysing its correlation and imaging features. From July 2008 to June 2012, 102 consecutive MRI-detected NME lesions were subsequently evaluated with US. Lesions were evaluated according to the established Breast Imaging Reporting and Data System (BI-RADS) lexicon. The correlation between MRI-detected NME lesion characteristics, lesion size, histopathological findings and features at second-look US were analysed...
November 2015: Breast Journal
https://www.readbyqxmd.com/read/26325319/novel-sodium-fusidate-loaded-film-forming-hydrogel-with-easy-application-and-excellent-wound-healing
#20
Dong Wuk Kim, Kyung Soo Kim, Youn Gee Seo, Beom-Jin Lee, Young Joon Park, Yu Seok Youn, Jong Oh Kim, Chul Soon Yong, Sung Giu Jin, Han-Gon Choi
To develop a novel sodium fusidate-loaded film-forming hydrogel (FFH) for easy application and excellent wound healing, various FFH formulations and corresponding FFH dried films were prepared with drug, polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), propylene glycol, ethanol and water, and their film forming times, mechanical properties, drug release, in vivo wound healing in rat and histopathology were assessed. The sodium fusidate-loaded FFH composed of sodium fusidate/PVP/PVA/propylene glycol/ethanol/water at the weight ratio of 1/2/12/3/8/74 could form a corresponding dried film in the wound sites promptly due to fast film-forming time of about 4 min...
November 10, 2015: International Journal of Pharmaceutics
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