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https://www.readbyqxmd.com/read/28919696/potential-of-pomegranate-fruit-extract-punica-granatum-linn-to-increase-vascular-endothelial-growth-factor-and-platelet-derived-growth-factor-expressions-on-the-post-tooth-extraction-wound-of-cavia-cobaya
#1
Intan Nirwana, Priyawan Rachmadi, Devi Rianti
BACKGROUND: Pomegranates fruit extracts have several activities, among others, anti-inflammatory, antibacterial, and antioxidants that have the main content punicalagin and ellagic acid. Pomegranate has the ability of various therapies through different mechanisms. Vascular endothelial growth factor (VEGF) function was to form new blood vessels produced by various cells one of them was macrophages. Platelet-derived growth factor (PDGF) was a growth factor proven chemotactic, increased fibroblast proliferation and collagen matrix production...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28899616/risk-factors-for-dental-problems-recommendations-for-oral-health-in-infancy
#2
REVIEW
Yvonne Wagner, Roswitha Heinrich-Weltzien
Primary care providers, gynaecologists and paediatricians have to be aware of the importance of oral health in infancy and possible consequences for child's development, growth, health and quality of life. Oral diseases, particularly dental caries, developmental defects of the dental tissues and periodontal or orthodontic issues have a complex and interrelated aetiology with common, primarily behavioral based risk factors. A sugar-rich diet is the key risk factor with detrimental consequences for general and oral health, particularly in combination with an insufficient oral hygiene...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28898247/prevalence-of-acromegaly-in-patients-with-symptoms-of-sleep-apnea
#3
Gemma Sesmilo, Eugenia Resmini, Marcel Sambo, Concepción Blanco, Fernando Calvo, Fernando Pazos, Pablo Fernández-Catalina, Purificación Martínez de Icaya, Concepción Páramo, Carmen Fajardo, Mónica Marazuela, Cristina Álvarez-Escolá, Juan Jose Díez, Verónica Perea
Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40-125 cases/million but targeted universal screening studies have found a higher prevalence (about 10 fold). The aim of the ACROSAHS study was to investigate the prevalence of acromegaly and acromegaly comorbidities in patients with sleep apnea symptoms and acral enlargement. ACROSAHS was a Spanish prospective non-interventional epidemiological study in 13 Hospital sleep referral units...
2017: PloS One
https://www.readbyqxmd.com/read/28888853/monitoring-guidance-for-patients-with-hypophosphatasia-treated-with-asfotase-alfa
#4
REVIEW
Priya S Kishnani, Eric T Rush, Paul Arundel, Nick Bishop, Kathryn Dahir, William Fraser, Paul Harmatz, Agnès Linglart, Craig F Munns, Mark E Nunes, Howard M Saal, Lothar Seefried, Keiichi Ozono
Hypophosphatasia (HPP) is a rare, inherited, systemic, metabolic disorder caused by autosomal recessive mutations or a single dominant-negative mutation in the gene encoding tissue-nonspecific alkaline phosphatase (TNSALP). The disease is associated with a broad range of signs, symptoms, and complications, including impaired skeletal mineralization, altered calcium and phosphate metabolism, recurrent fractures, pain, respiratory problems, impaired growth and mobility, premature tooth loss, developmental delay, and seizures...
July 25, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28886764/advanced-scaffolds-for-dental-pulp-and-periodontal-regeneration
#5
REVIEW
Marco C Bottino, Divya Pankajakshan, Jacques E Nör
No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. Three-dimensional easy-to-fit antibiotic-eluting nanofibers, combined with injectable scaffolds, enriched or not with stem cells and/or growth factors, may increase the likelihood of achieving predictable dental pulp regeneration. Periodontitis is an aggressive disease that impairs the integrity of tooth-supporting structures and may lead to tooth loss...
October 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28886584/human-pulpal-blood-flow-in-different-root-formation-stages-measured-with-transmitted-light-plethysmography
#6
Khongorzul Ganbold, Satoko Kakino, Hideharu Ikeda, Michiyo Miyashin
OBJECTIVES: To determine the pulp vitality after traumatic injury, dentists often use pulp sensitivity tests, which can be ambiguous in young permanent teeth with incomplete root formation. Transmitted-light plethysmography (TLP) is a non-invasive objective method that uses a 525-nm LED to detect blood volume change in the pulp. The present study aimed (1) to investigate pulpal blood flow with TLP and optical characteristics in healthy permanent maxillary incisors in different root formation stages, and (2) to assess the influences of body growth of the children and tooth color on the TLP amplitude...
August 25, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28886415/burden-of-higher-lead-exposure-in-african-americans-starts-in-utero-and-persists-into-childhood
#7
Andrea E Cassidy-Bushrow, Alexandra R Sitarik, Suzanne Havstad, Sung Kyun Park, Lawrence F Bielak, Christine Austin, Christine Cole Johnson, Manish Arora
BACKGROUND: Recent public health lead crises in urban areas emphasize the need to better understand exposure to environmental toxicants, particularly in higher risk groups. Although African-American children have the highest prevalence of elevated blood lead levels in the United States, little is known about when this trajectory of disproportionate burden of lead exposure first emerges. OBJECTIVES: Using tooth-matrix biomarkers that directly measure fetal and early childhood metal levels, the primary goal of this study was to determine if there were racial disparities in lead levels during fetal development and early childhood...
September 5, 2017: Environment International
https://www.readbyqxmd.com/read/28855950/sea-urchin-growth-dynamics-at-microstructural-length-scale-revealed-by-mn-labeling-and-cathodoluminescence-imaging
#8
Przemysław Gorzelak, Aurélie Dery, Philippe Dubois, Jarosław Stolarski
BACKGROUND: Fluorochrome staining is among the most widely used techniques to study growth dynamics of echinoderms. However, it fails to detect fine-scale increments because produced marks are commonly diffusely distributed within the skeleton. In this paper we investigated the potential of trace element (manganese) labeling and subsequent cathodoluminescence (CL) imaging in fine-scale growth studies of echinoderms. RESULTS: Three species of sea urchins (Paracentrotus lividus, Echinometra sp...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28852039/laser-assisted-rapid-mineralization-of-human-tooth-enamel
#9
Muyang Sun, Nier Wu, Haifeng Chen
The human body has difficulty repairing damaged dental enamel, an acellular hard tissue. Researchers have sought feasible biomimicry strategies to repair enamel defects; however, few have been successfully translated to clinical applications. In this study, we propose a new method for achieving rapid enamel mineralization under a near-physiological environment. Through treatment with a laser and chelating agents, 15 μm crystals could be grown compactly on an enamel substrate in less than 20 min. The compact crystal layer had similar structure as native enamel prisms and high elastic modulus...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846464/the-presence-of-mmp-20-reinforces-biomimetic-enamel-regrowth
#10
S Prajapati, Q Ruan, K Mukherjee, S Nutt, J Moradian-Oldak
Biomimetic synthesis of artificial enamel is a promising strategy for the prevention and restoration of defective enamel. We have recently reported that a hydrogel system composed of chitosan-amelogenin (CS-AMEL) and calcium phosphate is effective in forming an enamel-like layer that has a seamless interface with natural tooth surfaces. Here, to improve the mechanical system function and to facilitate the biomimetic enamel regrowth, matrix metalloproteinase-20 (MMP-20) was introduced into the CS-AMEL hydrogel...
August 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28839489/giant-complex-odontoma-of-mandible-a-spectacular-case-report
#11
Narjiss Akerzoul, Saliha Chbicheb, Wafaa El Wady
INTRODUCTION: Odontomas are considered as benign tumors of odontogenic tissue origin and are more over non-aggressive. They can also be categorized as hamartomas and are a result of developmental malformation of odontogenic tissues. As the name suggests, they are composed of mature tooth substances. They possess limited and slow growth potential and are well differentiated. They can be ectodermal, mesodermal or mixed in origin. Mixed variety may be further divided into compound or complex depending upon their radio-graphical resemblance to the tooth...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28835631/neuropilin-1-sequestration-by-neuropathogenic-mutant-glycyl-trna-synthetase-is-permissive-to-vascular-homeostasis
#12
James N Sleigh, Adriana Gómez-Martín, Na Wei, Ge Bai, Xiang-Lei Yang, Giampietro Schiavo
The mechanism by which dominantly inherited mutations in the housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve toxicity resulting in Charcot-Marie-Tooth disease type 2D (CMT2D) is still largely unresolved. The transmembrane receptor protein neuropilin 1 (Nrp1) was recently identified as an aberrant extracellular binding partner of mutant GlyRS. Formation of the Nrp1/mutant GlyRS complex antagonises Nrp1 interaction with one of its main natural ligands, vascular endothelial growth factor-A (VEGF-A), contributing to neurodegeneration...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835018/effect-of-fgf-2-tgf-%C3%AE-1-and-bmps-on-teno-ligamentogenesis-and-osteo-cementogenesis-of-human-periodontal-ligament-stem-cells
#13
Sun-Yi Hyun, Ji-Hye Lee, Kyung-Jung Kang, Young-Joo Jang
The periodontal ligament (PDL) is the connective tissue between tooth root and alveolar bone containing mesenchymal stem cells (MSC). It has been suggested that human periodontal ligament stem cells (hPDLSCs) differentiate into osteo/cementoblast and ligament progenitor cells. The periodontitis is a representative oral disease where the PDL tissue is collapsed, and regeneration of this tissue is important in periodontitis therapy. Fibroblast growth factor-2 (FGF-2) stimulates proliferation and differentiation of fibroblastic MSCs into various cell lineages...
August 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28832934/relative-tooth-size-at-birth-in-primates-life-history-correlates
#14
Timothy D Smith, Magdalena N Muchlinski, Wade R Bucher, Christopher J Vinyard, Christopher J Bonar, Sian Evans, Lawrence E Williams, Valerie B DeLeon
OBJECTIVES: Dental eruption schedules have been closely linked to life history variables. Here we examine a sample of 50 perinatal primates (28 species) to determine whether life history traits correlate with relative tooth size at birth. MATERIALS AND METHODS: Newborn primates were studied using serial histological sectioning. Volumes of deciduous premolars (dp(2) -dp(4) ), replacement teeth (if any), and permanent molars (M(1-2/3) ) of the upper jaw were measured and residuals from cranial length were calculated with least squares regressions to obtain relative dental volumes (RDVs)...
August 19, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28820323/non-surgical-model-for-alveolar-bone-regeneration-by-bone-morphogenetic-protein-2-7-gene-therapy
#15
Mariko Kawai, Yo-Hei Kataoka, Junya Sonobe, Hiromitsu Yamamoto, Masakazu Inubushi, Takuya Ishimoto, Takayoshi Nakano, Hiroki Maruyama, Jun-Ichi Miyazaki, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura
BACKGROUND: Alveolar bone is a critical tissue for tooth retention; however, once alveolar bone is lost, it may not spontaneously regenerate. Currently, bone grafts or artificial bone are commonly used for alveolar bone regeneration therapy. However, these therapies require surgical procedures, which present risks, particularly in aged patients. Therefore, the development of alveolar bone regeneration techniques that do not require surgical procedures is critical. It is well known that stem cells present in the periosteal and periodontal ligament may be induced to differentiate into osteogenic cells...
August 18, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28796340/application-of-differentiated-human-tonsil-derived-stem-cells-to-trembler-j-mice
#16
Saeyoung Park, Yoonyoung Choi, Geon Kwak, Young Bin Hong, Namhee Jung, Jieun Kim, Byung-Ok Choi, Sung-Chul Jung
INTRODUCTION: Mesenchymal stem cells (MSCs) can differentiate into various cell types. METHODS: In this study we investigated the potential of human tonsil-derived MSCs (T-MSCs) for neuromuscular regeneration in trembler-J (Tr-J) mice, a model for Charcot-Marie-Tooth disease type 1A (CMT1A). RESULTS: T-MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle-related markers (including troponin I type 1, and myogenin), and the formation of myotubes in vitro...
August 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28779848/tgf-%C3%AE-1-stimulates-cyclooxygenase-2-expression-and-pge2-production-of-human-dental-pulp-cells-role-of-alk5-smad2-and-mek-erk-signal-transduction-pathways
#17
Po-Shuen Lin, Ru-Hsiu Cheng, Mei-Chi Chang, Jang-Jaer Lee, Hsiao-Hua Chang, Wei-Ling Huang, Sin-Yuet Yeung, Ya-Ching Chang, Jiiang-Huei Jeng
BACKGROUND/PURPOSES: TGF-β1 is an important growth factor that may influence the odontoblast differentiation and matrix deposition in the reactionary/reparative dentinogenesis to dental caries or other tooth injuries. TGF-β1 exerts its effects through various signaling pathways, such as Smads and MAPKs. Cyclooxygenase-2 (COX-2) is a membrane-associated enzyme that produces prostaglandin E2 (PGE2) at sites of pulpal injury and inflammation, which leads to tissue swelling, redness and pain...
August 2, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28774721/ontogenetic-and-functional-modularity-in-the-rodent-mandible
#18
Rachel A Menegaz, Matthew J Ravosa
The material properties of diets consumed by juvenile individuals are known to affect adult morphological outcomes. However, much of the current experimental knowledge regarding dietary effects on masticatory form is derived from studies in which individuals are fed a non-variable diet for the duration of their postweaning growth period. Thus, it remains unclear how intra-individual variation in diet, due to ontogenetic variation in feeding behaviors or seasonal resource fluctuations, affects the resulting adult morphology...
June 8, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28764928/tissue-engineering-dentin-pulp-complex-regeneration-approaches-a-review
#19
REVIEW
Batool Hashemi-Beni, Maryam Khoroushi, Mohammad Reza Foroughi, Saeed Karbasi, Abbas Ali Khademi
Dental pulp is a highly specialized tissue that preserves teeth. It is important to maintain the capabilities of dental pulp before a pulpectomy by creating a local restoration of the dentin-pulp complex from residual dental pulp. The articles identified were selected by two reviewers based on entry and exit criteria. All relevant articles indexed in PubMed, Springer, Science Direct, and Scopus with no limitations from 1961 to 2016 were searched. Factors investigated in the selected articles included the following key words: Dentin-Pulp Complex, Regeneration, Tissue Engineering, Scaffold, Stem Cell, and Growth Factors...
July 25, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28760288/surgery-first-approach-in-correcting-skeletal-class-iii-malocclusion-with-mandibular-asymmetry
#20
Hyeon-Shik Hwang, Min-Hee Oh, Hee-Kyun Oh, Heesoo Oh
This case report describes a surgical orthodontic case that used the recently introduced surgery-first approach to correct a severe skeletal Class III malocclusion. A 19-year-old woman presented with severe mandibular prognathism and facial asymmetry; she had been waiting for growth completion in order to pursue surgical correction. After prediction of the postsurgical tooth movement and surgical simulation, 2-jaw surgery that included maxillary advancement and differential mandibular setback was performed using a surgery-first approach...
August 2017: American Journal of Orthodontics and Dentofacial Orthopedics
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