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https://www.readbyqxmd.com/read/28097682/evaluation-of-perforated-demineralized-dentin-scaffold-on-bone-regeneration-in-critical-size-sheep-iliac-defects
#1
Md Arafat Kabir, Masaru Murata, Toshiyuki Akazawa, Kaoru Kusano, Katsuhisa Yamada, Manabu Ito
OBJECTIVES: Regenerating critical-size bone injury is a major problem that continues to inspire the design of new graft materials. Therefore, tissue engineering has become a novel approach for targeting bone regeneration applications. Human teeth are a rich source of stem cells, matrix, trace metal ions, and growth factors. A vital tooth-derived demineralized dentin matrix is acid-insoluble and composed of cross-linked collagen with growth factors. In this study, we recycled human non-functional tooth into a unique geometric dentin scaffold, entitled perforated root-demineralized dentin matrix (PR-DDM)...
January 17, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28078880/orthodontic-forces-modulate-insulin-like-growth-factor-binding-protein-5-changes-in-gingival-crevicular-fluid
#2
A Ballini, L Santacroce, S Cantore, R Saini, F Mastrangelo, A Desiate, S Scacco
Orthodontic tooth movement results from the response of the periodontal tissue to orthodontic force, which leads to modeling and remodeling of the surrounding alveolar bone. The response is considered to occur through the activation of specific signaling pathways, many of which are known, all acting to ultimately result in tooth movement. Much is known about the actions of these two cells, and the signaling pathways that affect them, both in bone and orthodontic literature, however, to date, little work has been carried out to examine the effect of the insulin-like growth factor binding proteins (IGFBP) in orthodontics...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28074842/analysis-of-the-fgf-gene-family-provides-insights-into-aquatic-adaptation-in-cetaceans
#3
Kiwoong Nam, Kyeong Won Lee, Oksung Chung, Hyung-Soon Yim, Sun-Shin Cha, Sae-Won Lee, JeHoon Jun, Yun Sung Cho, Jong Bhak, João Pedro de Magalhães, Jung-Hyun Lee, Jae-Yeon Jeong
Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28072957/-a-cross-sectional-survey-on-the-patterns-of-primary-teeth-eruption-in-2-581-children
#4
R X Li, Y Hu
Objective: To investigate the patterns of primary teeth eruption by a cross-sectional survey in 0-40 months old children in Chongqing and to provide normal timetables of tooth eruption that are practical in general physical growth assessment. Method: Data of 2 581 0-40 months old healthy children were collected from January 2014 to January 2016 at Children's Hospital of Chongqing Medical University. General information was recorded by primary child health care doctors, including age, gender, gestation age, birth weight, time and sequence of first primary tooth eruption, number of teeth and age of totally primary teeth emergence...
January 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28068182/improvement-of-antibacterial-efficacy-through-synergistic-effect-in-photodynamic-therapy-based-on-thiazinium-chromophores-against-planktonic-and-biofilm-associated-periodontopathogens
#5
Eva-Maria Decker, Valentin Bartha, Christiane von Ohle
OBJECTIVE: Aim of the study was to improve the antibacterial efficacy of toluidine blue (TBO)/methylene blue (MB)-mediated photodynamic systems with light-emitting diode (LED) or laser irradiation administered to planktonic and biofilm-associated periodontopathogens. BACKGROUND DATA: Antibacterial photodynamic therapy (PDT) is a common, noninvasive adjunctive clinical method to inactivate microorganisms. So far, the disadvantage of this method has been its limited effectiveness in eliminating pathogens...
January 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28052552/celsr2-encoding-a-planar-cell-polarity-protein-is-a-putative-gene-in-joubert-syndrome-with-cortical-heterotopia-microophthalmia-and-growth-hormone-deficiency
#6
Thierry Vilboux, May Christine V Malicdan, Joseph C Roney, Andrew R Cullinane, Joshi Stephen, Deniz Yildirimli, Joy Bryant, Roxanne Fischer, Meghana Vemulapalli, James C Mullikin, Peter J Steinbach, William A Gahl, Meral Gunay-Aygun
Joubert syndrome is a ciliopathy characterized by a specific constellation of central nervous system malformations that result in the pathognomonic "molar tooth sign" on imaging. More than 27 genes are associated with Joubert syndrome, but some patients do not have mutations in any of these genes. Celsr1, Celsr2, and Celsr3 are the mammalian orthologues of the drosophila planar cell polarity protein, flamingo; they play important roles in neural development, including axon guidance, neuronal migration, and cilium polarity...
January 4, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28050518/revitalization-of-an-immature-permanent-mandibular-molar-with-a-necrotic-pulp-using-platelet-rich-fibrin-a-case-report
#7
Dayalan Subash, Krishnamma Shoba, Shibu Aman, Srinivasan Kumar Indu Bharkavi
Any insult to the pulp during its development causes cessation of dentin formation and root growth. Pulpal status and degree of root development are the decisive factors in the treatment approach. Various treatment options have been tried like surgery with root-end sealing, calcium hydroxide-apexification, placement of apical plug and regenerative endodontic procedures to induce apexogenesis. An ideal scenario for a necrosed tooth with immature root would be continued root development coupled with regeneration of pulp tissue...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049837/dinosaur-incubation-periods-directly-determined-from-growth-line-counts-in-embryonic-teeth-show-reptilian-grade-development
#8
Gregory M Erickson, Darla K Zelenitsky, David Ian Kay, Mark A Norell
Birds stand out from other egg-laying amniotes by producing relatively small numbers of large eggs with very short incubation periods (average 11-85 d). This aspect promotes high survivorship by limiting exposure to predation and environmental perturbation, allows for larger more fit young, and facilitates rapid attainment of adult size. Birds are living dinosaurs; their rapid development has been considered to reflect the primitive dinosaurian condition. Here, nonavian dinosaurian incubation periods in both small and large ornithischian taxa are empirically determined through growth-line counts in embryonic teeth...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045323/the-process-of-mineralisation-in-the-development-of-human-tooth
#9
S Caruso, S Bernardi, M Pasini, M R Giuca, R Docimo, M A Continenza, R Gatto
Tooth development and mineralisation are processes that derive from different tissues interactions, in particular ectodermal and mesenchymal layers. These interactions are responsible for the formation of unique structures with a particular chemical composition. Despite differences, mineralised tissues are similar and they derive by highly concerted extracellular processes that involve matrix proteins, proteases, and mineral ion fluxes that collectively regulate the nucleation, growth and organisation of forming mineral crystals...
December 2016: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/28043400/dental-issues-in-lacrimo-auriculo-dento-digital-syndrome-an-autosomal-dominant-condition-with-clinical-and-genetic-variability
#10
M J Hajianpour, Hannah Bombei, Scott M Lieberman, Rachael Revell, Rachana Krishna, Robert Gregorsok, Simon Kao, Jeff M Milunsky
BACKGROUND AND OVERVIEW: Lacrimo-auriculo-dento-digital (LADD) syndrome is an autosomal dominant disorder with variable lacrimal and salivary gland hypoplasia and aplasia, auricular anomalies and hearing loss, dental defects and caries, and digital anomalies. CASE DESCRIPTION: The authors present the cases of 2 unrelated children with enamel defects and history of dry mouth leading to recurrent dental caries. The referring diagnoses were Sjögren disease and hypohidrotic ectodermal dysplasia, respectively...
December 30, 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28035998/tgf-%C3%AE-and-physiological-root-resorption-of-deciduous-teeth
#11
Emi Shimazaki, Takeo Karakida, Ryuji Yamamoto, Saeko Kobayashi, Makoto Fukae, Yasuo Yamakoshi, Yoshinobu Asada
The present study was performed to examine how transforming growth factor β (TGF-β) in root-surrounding tissues on deciduous teeth regulates the differentiation induction into odontoclasts during physiological root resorption. We prepared root-surrounding tissues with (R) or without (N) physiological root resorption scraped off at three regions (R1-R3 or N1-N3) from the cervical area to the apical area of the tooth and measured both TGF-β and the tartrate-resistant acid phosphatase (TRAP) activities. The TGF-β activity level was increased in N1-N3, whereas the TRAP activity was increased in R2 and R3...
December 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28027709/conditioned-medium-from-periodontal-ligament-stem-cells-enhances-periodontal-regeneration
#12
Mizuki Nagata, Kengo Iwasaki, Keiko Akazawa, Motohiro Komaki, Naoki Yokoyama, Yuichi Izumi, Ikuo Morita
Periodontal disease is one of the most common infectious diseases in adults and is characterized by the destruction of tooth-supporting tissues. Mesenchymal stem cells (MSCs) comprise the mesoderm-originating stem cell population, which has been studied and used for cell therapy. However, because of the lower rate of cell survival after MSC transplantation in various disease models, paracrine factions of MSCs have been receiving increased attentions as a regenerative mechanism. The aim of this study was to investigate the regenerative potential of transplanted of conditioned medium (CM) obtained from cultured periodontal ligament stem cells (PDLSCs), the adult stem cell population in tooth-supporting tissues, using a rat periodontal defect model...
December 27, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28024757/expression-of-inflammatory-cytokines-and-chemokines-in-replanted-permanent-teeth-with-external-root-resorption
#13
Juliana Vilela Bastos, Tarcilia A Silva, Enrico A Colosimo, Maria Ilma S Côrtes, Daniela Augusta B Ferreira, Eugenio Marcos A Goulart, Ricardo S Gomez, Walderez O Dutra
INTRODUCTION: The progressive forms of inflammatory external root resorption (IERR) and replacement external root resorption (RERR) are serious complications and the main causes of tooth loss after replantation. This study aimed to investigate the expression pattern of inflammatory molecules in extracted human teeth presenting with external root resorption (ERR) after replantation. METHODS: Root fragments from 22 teeth showing IERR and 20 teeth with RERR were triturated using a homogenizer to extract inflammatory molecules...
December 23, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/28001241/effect-of-edta-on-tgf-%C3%AE-1-released-from-the-dentin-matrix-and-its-influence-on-dental-pulp-stem-cell-migration
#14
Lidiany Freitas Gonçalves, Ana Paula Fernandes, Leopoldo Cosme-Silva, Fabio Antonio Colombo, Natália Silva Martins, Thais Marchini Oliveira, Tomaz Henrique Araujo, Vivien Thiemy Sakai
Bioactive molecules stored in dentin, such as transforming growth factor beta1 (TGF-b1), may be involved in the signaling events related to dental tissue repair. The authors conducted an in vitro evaluation of the amount of TGF-b1 released from dentin slices after treatment with 10% ethylenediaminetetraacetic acid (EDTA), 2.5% sodium hypochlorite (NaOCl) or phosphate-buffered saline (PBS), and the effect of this growth factor on stem cell migration from human exfoliated deciduous teeth (SHED). Sixty 1-mm-thick tooth slices were prepared with or without the predentin layer, and treated with either 10% EDTA for 1 minute, 2...
December 22, 2016: Brazilian Oral Research
https://www.readbyqxmd.com/read/27989519/the-function-of-appendage-patterning-genes-in-mandible-development-of-the-sexually-dimorphic-stag-beetle
#15
Hiroki Gotoh, Robert A Zinna, Yuki Ishikawa, Hitoshi Miyakawa, Asano Ishikawa, Yasuhiro Sugime, Douglas J Emlen, Laura C Lavine, Toru Miura
One of the defining features of the evolutionary success of insects is the morphological diversification of their appendages, especially mouthparts. Although most insects share a common mouthpart ground plan, there is remarkable diversity in the relative size and shapes of these appendages among different insect lineages. One of the most prominent examples of mouthpart modification can be found in the enlargement of mandibles in stag beetles (Coleoptera, Insecta). In order to understand the proximate mechanisms of mouthpart modification, we investigated the function of appendage-patterning genes in mandibular enlargement during extreme growth of the sexually dimorphic mandibles of the stag beetle Cyclommatus metallifer...
December 16, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27982023/spatial-signalling-mediated-by-the-transforming-growth-factor-%C3%AE-signalling-pathway-during-tooth-formation
#16
Xin-Yu He, Ke Sun, Ruo-Shi Xu, Jia-Li Tan, Cai-Xia Pi, Mian Wan, Yi-Ran Peng, Ling Ye, Li-Wei Zheng, Xue-Dong Zhou
Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated by a variety of conserved and specific temporal-spatial signalling pathways. It is well known that suspensions of tooth germ cells can form tooth-like structures after losing the positional information provided by the epithelial and mesenchymal tissues. However, the particular stage in which the tooth germ cells start to form tooth-like structures after losing their positional information remains unclear...
December 16, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27979302/3-6-anhydro-l-galactose-a-rare-sugar-from-agar-a-new-anticariogenic-sugar-to-replace-xylitol
#17
Eun Ju Yun, Ah Reum Lee, Jung Hyun Kim, Kyung Mun Cho, Kyoung Heon Kim
The significance for anticariogenic sugar substitutes is growing due to increasing demands for dietary sugars and rising concerns of dental caries. Xylitol is widely used as an anticariogenic sugar substitute, but the inhibitory effects of xylitol on Streptococcus mutans, the main cause of tooth decay, are exhibited only at high concentrations. Here, the inhibitory effects of 3,6-anhydro-l-galactose (AHG), a rare sugar from red macroalgae, were evaluated on S. mutans, in comparison with those of xylitol. In the presence of 5g/l of AHG, the growth of S...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27965495/use-of-the-tooth-coronal-pulp-index-for-recognition-of-the-pubertal-growth-period
#18
Fehmieh R Nawaya, Ahmad S Burhan
AIM: The present study aimed to investigate the association between the tooth coronal index (TCI) and the pubertal growth stages (PGS) for children and adolescents. MATERIALS AND METHODS: A cross-sectional study was performed using retrospectively collected panoramic and hand-wrist radiographs of 262 individuals (125 males, 137 females). The coronal height (CH) and the coronal pulp cavity height (CPCH) of the left mandibular teeth were measured. Then the TCI for which was calculated according to Ikeda et al (1985)...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27959403/bcl11b-regulates-enamel-matrix-protein-expression-and-dental-epithelial-cell-differentiation-during-rat-tooth-development
#19
Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Amelogenesis, beginning with thickened epithelial aggregation and ending with highly mineralized enamel formation, is a process mediated by a complex signaling network that involves several molecules, including growth and transcription factors. During early tooth development, the transcription factor B‑cell CLL/lymphoma 11B (Bcl11b) participates in dental epithelial cell proliferation and differentiation. However, whether it affects the postnatal regulation of enamel matrix protein expression and ameloblast differentiation remains unclear...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27940618/from-teeth-to-baleen-and-raptorial-to-bulk-filter-feeding-in-mysticete-cetaceans-the-role-of-paleontological-genetic-and-geochemical-data-in-feeding-evolution-and-ecology
#20
Annalisa Berta, Agnese Lanzetti, Eric G Ekdale, Thomas A Deméré
The origin of baleen and filter feeding in mysticete cetaceans occurred sometime between approximately 34 and 24 million years ago and represents a major macroevolutionary shift in cetacean morphology (teeth to baleen) and ecology (raptorial to filter feeding). We explore this dramatic change in feeding strategy by employing a diversity of tools and approaches: morphology, molecules, development, and stable isotopes from the geological record. Adaptations for raptorial feeding in extinct toothed mysticetes provide the phylogenetic context for evaluating morphological apomorphies preserved in the skeletons of stem and crown edentulous mysticetes...
December 2016: Integrative and Comparative Biology
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