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https://www.readbyqxmd.com/read/28796340/application-of-differentiated-human-tonsil-derived-stem-cells-to-trembler-j-mice
#1
Saeyoung Park, Yoonyoung Choi, Geon Kwak, Young Bin Hong, Namhee Jung, Jieun Kim, Byung-Ok Choi, Sung-Chul Jung
INTRODUCTION: Mesenchymal stem cells (MSCs) can differentiate into various cell types. METHODS: We investigated the potential of human tonsil-derived MSCs (T-MSCs) for neuromuscular regeneration in trembler-J (Tr-J) mice: a model for Charcot-Marie-Tooth disease type 1A (CMT1A. RESULTS: T-MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle-related markers (including troponin I type 1, and myogenin), and the formation of myotubes in vitro...
August 10, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28779848/tgf-%C3%AE-1-stimulates-cyclooxygenase-2-expression-and-pge2-production-of-human-dental-pulp-cells-role-of-alk5-smad2-and-mek-erk-signal-transduction-pathways
#2
Po-Shuen Lin, Ru-Hsiu Cheng, Mei-Chi Chang, Jang-Jaer Lee, Hsiao-Hua Chang, Wei-Ling Huang, Sin-Yuet Yeung, Ya-Ching Chang, Jiiang-Huei Jeng
BACKGROUND/PURPOSES: TGF-β1 is an important growth factor that may influence the odontoblast differentiation and matrix deposition in the reactionary/reparative dentinogenesis to dental caries or other tooth injuries. TGF-β1 exerts its effects through various signaling pathways, such as Smads and MAPKs. Cyclooxygenase-2 (COX-2) is a membrane-associated enzyme that produces prostaglandin E2 (PGE2) at sites of pulpal injury and inflammation, which leads to tissue swelling, redness and pain...
August 2, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28774721/ontogenetic-and-functional-modularity-in-the-rodent-mandible
#3
Rachel A Menegaz, Matthew J Ravosa
The material properties of diets consumed by juvenile individuals are known to affect adult morphological outcomes. However, much of the current experimental knowledge regarding dietary effects on masticatory form is derived from studies in which individuals are fed a non-variable diet for the duration of their postweaning growth period. Thus, it remains unclear how intra-individual variation in diet, due to ontogenetic variation in feeding behaviors or seasonal resource fluctuations, affects the resulting adult morphology...
June 8, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28764928/tissue-engineering-dentin-pulp-complex-regeneration-approaches-a-review
#4
REVIEW
Batool Hashemi-Beni, Maryam Khoroushi, Mohammad Reza Foroughi, Saeed Karbasi, Abbas Ali Khademi
Dental pulp is a highly specialized tissue that preserves teeth. It is important to maintain the capabilities of dental pulp before a pulpectomy by creating a local restoration of the dentin-pulp complex from residual dental pulp. The articles identified were selected by two reviewers based on entry and exit criteria. All relevant articles indexed in PubMed, Springer, Science Direct, and Scopus with no limitations from 1961 to 2016 were searched. Factors investigated in the selected articles included the following key words: Dentin-Pulp Complex, Regeneration, Tissue Engineering, Scaffold, Stem Cell, and Growth Factors...
July 25, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28760288/surgery-first-approach-in-correcting-skeletal-class-iii-malocclusion-with-mandibular-asymmetry
#5
Hyeon-Shik Hwang, Min-Hee Oh, Hee-Kyun Oh, Heesoo Oh
This case report describes a surgical orthodontic case that used the recently introduced surgery-first approach to correct a severe skeletal Class III malocclusion. A 19-year-old woman presented with severe mandibular prognathism and facial asymmetry; she had been waiting for growth completion in order to pursue surgical correction. After prediction of the postsurgical tooth movement and surgical simulation, 2-jaw surgery that included maxillary advancement and differential mandibular setback was performed using a surgery-first approach...
August 2017: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/28759313/glycosylation-of-dmp1-is-essential-for-chondrogenesis-of-condylar-cartilage
#6
Y Weng, Y Liu, H Du, L Li, B Jing, Q Zhang, X Wang, Z Wang, Y Sun
The mandibular condylar cartilage (MCC) shoulders force for the subchondral bone during mastication. The cartilage matrix contains various large molecules, such as type I, II, and X collagens and proteoglycans (PGs), which jointly play essential roles in maintaining cartilage characteristics. PGs play key roles in maintaining the elasticity of cartilage and providing a cushion against mastication forces. In addition to the well-known PGs, DMP1-PG, which is the PG form of dentin matrix protein 1 (DMP1), is a newly identified PG...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28759120/pit-and-fissure-sealants-for-preventing-dental-decay-in-permanent-teeth
#7
REVIEW
Anneli Ahovuo-Saloranta, Helena Forss, Tanya Walsh, Anne Nordblad, Marjukka Mäkelä, Helen V Worthington
BACKGROUND: Dental sealants were introduced in the 1960s to help prevent dental caries, mainly in the pits and fissures of occlusal tooth surfaces. Sealants act to prevent bacteria growth that can lead to dental decay. Evidence suggests that fissure sealants are effective in preventing caries in children and adolescents compared to no sealants. Effectiveness may, however, be related to caries incidence level of the population. This is an update of a review published in 2004, 2008 and 2013...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28758435/-treating-tissue-defects-following-tooth-removal-three-case-reports
#8
Rita Marton, Anna Martin, Szandra Lemperger, Péter Windisch
Following tooth removal, three dimensional hard- and soft-tissue loss take place. Spontaneous healing makes the defect more severe and results in collapsing tissues. Implant placement is not feasible. In the aestethic zone even fixed partial dentures will not deliver the expected result. Our aim was to demonstrate that only ridge preservation enables implant placement and also provides excellent aestetic result even at frontal areas. CBCT was made before and 6-8 months after ridge preservation. Vertical and socket area measurements were carried out and compared in pre-, and postoperative images...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28757702/clinical-characteristics-of-crouzon-syndrome
#9
L Balyen, L S Deniz Balyen, S Pasa
Crouzon syndrome (CS) is an genetic disorder with autosomal dominant inheritance caused by mutation of the gene for fibroblast growth factor receptor 2 (FGFR2) was described as one of the varieties of craniosynostosis. In this presented case, premature closure of the sutures had caused restricted skull growth and lack of space for the growing brain resulted to shallowed eyes and cranial and ophthalmic deformities and impairment in tooth development. Management of a patient of CS has two components. First is the release of prematurely fused sutures based on evidence of raised intracranial pressure...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28753925/pilot-study-using-a-chitosan-hydroxyapatite-implant-for-guided-alveolar-bone-growth-in-patients-with-chronic-periodontitis
#10
Fabiola Vaca-Cornejo, Héctor Macías Reyes, Sergio H Dueñas Jiménez, Ricardo A Llamas Velázquez, Judith M Dueñas Jiménez
Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis...
July 19, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28748043/fluoride-resistance-in-streptococcus-mutans-a-mini-review
#11
REVIEW
Ying Liao, Bernd W Brandt, Jiyao Li, Wim Crielaard, Cor Van Loveren, Dong Mei Deng
For decades, fluoride has been used extensively as an anti-caries agent. It not only protects dental hard tissue, but also inhibits bacterial growth and metabolism. The antimicrobial action of fluoride is shown in three main aspects: the acidogenicity, acidurance, and adherence to the tooth surface. To counteract the toxic effect of fluoride, oral bacteria are able to develop resistance to fluoride through either phenotypic adaptation or genotypic changes. Strains that acquire fluoride resistance through the latter route show stable resistance and can usually resist much higher fluoride levels than the corresponding wild-type strain...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28746823/irx1-regulates-dental-outer-enamel-epithelial-and-lung-alveolar-type-ii-epithelial-differentiation
#12
Wenjie Yu, Xiao Li, Steven Eliason, Miguel Romero-Bustillos, Ryan J Ries, Huojun Cao, Brad A Amendt
The Iroquois genes (Irx) appear to regulate fundamental processes that lead to cell proliferation, differentiation, and maturation during development. In this report, the Iroquois homeobox 1 (Irx1) transcription factor was functionally disrupted using a LacZ insert and LacZ expression demonstrated stage-specific expression during embryogenesis. Irx1 is highly expressed in the brain, lung, digits, kidney, testis and developing teeth. Irx1 null mice are neonatal lethal and this lethality it due to pulmonary immaturity...
September 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28746492/relationship-between-dental-calcification-and-skeletal-maturation-in-a-peruvian-sample
#13
Rocío M Lecca-Morales, Marcos J Carruitero
Objective: the objective of the study was to determine the relationship between dental calcification stages and skeletal maturation in a Peruvian sample. Methods: panoramic, cephalometric and carpal radiographs of 78 patients (34 girls and 44 boys) between 7 and 17 years old (9.90 ± 2.5 years) were evaluated. Stages of tooth calcification of the mandibular canine, first premolar, second premolar, and second molar and the skeletal maturation with a hand-wrist and a cervical vertebrae method were assessed...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28740330/soft-tissue-molding-technique-in-cleft-lip-and-palate-patient-using-laser-surgery-in-combination-with-orthodontic-appliance-a-case-report
#14
Pornpat Theerasopon, Tasanee Wangsrimongkol, Sajee Sattayut
BACKGROUND: Although surgical treatment protocols for cleft lip and palate patients have been established, many patients still have some soft tissue defects after complete healing from surgical interventions. These are excess soft tissue, high attached fraena and firmed tethering scares. These soft tissue defects resulted shallowing of vestibule, restricted tooth movement, compromised periodontal health and trended to limit the maxillary growth. The aim of this case report was to present a method of correcting soft tissue defects after conventional surgery in cleft lip and palate patient by using combined laser surgery and orthodontic appliance...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28740329/940-nm-diode-laser-assisted-excision-of-peripheral-ossifying-fibroma-in-a-neonate
#15
Nitesh Tewari, Vijay Prakash Mathur, Asit Mridha, Kalpana Bansal, Divesh Sardana
BACKGROUND: Peripheral ossifying fibroma associated with neonatal tooth extraction is a rare, benign reactive lesion, but its nature and location often scares the patient & parents for possibility of neoplasm. A high recurrence rate makes its histopathological examination and long term follow up important. CASE REPORT: A 2 months old boy presented with enlarging soft tissue growth on the anterior mandibular ridge. The history revealed extraction of two neonatal teeth at 2 weeks of age...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28737897/biogenic-hydroxyapatite-a-new-material-for-the-preservation-and-restoration-of-the-built-environment
#16
Ronald Joseph Turner, Joanna C Renshaw, Andrea Hamilton
Ordinary Portland Cement (OPC) is by weight the world's most produced man-made material, and consequently is used in a variety of applications in environments ranging from buildings, to nuclear wasteforms, and within the human body. In this paper, we present for the first time the direct deposition of biogenic hydroxyapatite onto the surface of OPC, in a synergistic process which relies upon the unique properties of the cement substrate. The synthesised hydroxyapatite is very similar to that found in nature; having a crystallite size, iron and carbonate substitution, and a semi-crystalline structure which identify that this biogenic hydroxyapatite is akin to that found in natural bone and tooth enamel...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28736808/comparative-cranial-ontogeny-of-tapirus-mammalia-perissodactyla-tapiridae
#17
S Rocio Moyano, Norberto P Giannini
Skull morphology in tapirs is particularly interesting due to the presence of a proboscis with important trophic, sensory and behavioral functions. Several studies have dealt with tapir skull osteology but chiefly in a comparative framework between fossil and recent species of tapirs. Only one study examined an aspect of cranial ontogeny, development of the sagittal crest (Holbrook. J Zool Soc Lond 2002; 256; 215). Our goal is to describe in detail the morphological changes that occur during the postnatal ontogeny of the skull in two representative tapir species, Tapirus terrestris and Tapirus indicus, and to explore possible functional consequences of their developmental trajectories...
July 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28735759/associations-between-tooth-loss-and-prognostic-biomarkers-and-the-risk-for-cardiovascular-events-in-patients-with-stable-coronary-heart-disease
#18
Ola Vedin, Emil Hagström, Ollie Östlund, Alvaro Avezum, Andrzej Budaj, Marcus D Flather, Robert A Harrington, Wolfgang Koenig, Joseph Soffer, Agneta Siegbahn, Philippe Gabriel Steg, Ralph A H Stewart, Lars Wallentin, Harvey D White, Claes Held
BACKGROUND: Underlying mechanisms behind the hypothesized relationship between periodontal disease (PD) and coronary heart disease (CHD) have been insufficiently explored. We evaluated associations between self-reported tooth loss- a marker of PD- and prognostic biomarkers in 15,456 (97%) patients with stable CHD in the global STABILITY trial. METHODS AND RESULTS: Baseline blood samples were obtained and patients reported their number of teeth according to the following tooth loss levels: "26-32 (All)" [lowest level], "20-25", "15-19", "1-14", and "No Teeth" [highest level]...
July 17, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28733464/lineage-tracing-of-epithelial-cells-in-developing-teeth-reveals-two-strategies-for-building-signaling-centers
#19
Wei Du, Jimmy Kuang-Hsien Hu, Wen Du, Ophir D Klein
An important event in organogenesis is the formation of signaling centers, which are clusters of growth-factor secreting cells. In the case of tooth development, sequentially formed signaling centers known as the initiation knot (IK) and the enamel knot (EK) regulate morphogenesis. However, despite the importance of signaling centers, their origin, as well as the fate of the cells composing them, remain open questions. Here, using lineage tracing of distinct epithelial populations, we found that the EK of the mouse incisor is derived de novo from a group of SRY-box 2 (Sox2)-expressing cells in the posterior half of the tooth germ...
July 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28731540/participation-of-osteoclastogenic-factors-in-immunopathogenesis-of-human-chronic-periapical-lesions
#20
S C L T Santos, L A Couto, J M Fonseca, F C A Xavier, A C L Figueiredo, V S Freitas, R A Freitas, J N Santos, A C G Henriques
BACKGROUND: Chronic periapical lesions (CPLs) are common lesions of the oral cavity and are the result of caries, tooth fracture, iatrogenic causes, or factors causing contamination and pulp necrosis. Inflammatory cells participate in the expansion of CPLs by releasing factors that stimulate or inhibit osteolytic activity. The objective of this study was to investigate the participation of RANKL, TNF-α, cathepsin K, IL-33, and OPG in the development of radicular cysts (RCs) and periapical granulomas (PGs)...
July 21, 2017: Journal of Oral Pathology & Medicine
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