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https://www.readbyqxmd.com/read/27915340/2q33-1q34-deletion-in-a-girl-with-brain-anomalies-and-anorectal-malformation
#1
Luisa Ronzoni, Antonio Novelli, Giulia Brisighelli, Angela Peron, Fabio Triulzi, Vera Bianchi, Ernesto Leva, Maria F Bedeschi
2q33 deletions are considered to constitute a distinct clinical entity (Glass syndrome or 2q33 microdeletion syndrome) with a characteristic phenotype. Most patients have moderate to severe developmental delay, speech delay, a particular behavioural phenotype, feeding problems, growth restriction, a typical facial appearance, thin and sparse hair, tooth abnormalities, and skeletal anomalies. Here, we report on a patient with a 2q33.1q34 deletion spanning 8.3 Mb of genomic DNA. Although her clinical features are very reminiscent of the 2q33 microdeletion syndrome, she also presented with brain and anorectal malformations...
December 3, 2016: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/27913821/theobromine-upregulates-osteogenesis-by-human-mesenchymal-stem-cells-in-vitro-and-accelerates-bone-development-in-rats
#2
Bret H Clough, Joni Ylostalo, Elizabeth Browder, Eoin P McNeill, Thomas J Bartosh, H Ralph Rawls, Tetsuo Nakamoto, Carl A Gregory
Theobromine (THB) is one of the major xanthine-like alkaloids found in cacao plant and a variety of other foodstuffs such as tea leaves, guarana and cola nuts. Historically, THB and its derivatives have been utilized to treat cardiac and circulatory disorders, drug-induced nephrotoxicity, proteinuria and as an immune-modulator. Our previous work demonstrated that THB has the capacity to improve the formation of hydroxyl-apatite during tooth development, suggesting that it may also enhance skeletal development...
December 2, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27909893/osteogain%C3%A2-loaded-onto-an-absorbable-collagen-sponge-induces-attachment-and-osteoblast-differentiation-of-st2-cells-in-vitro
#3
Richard J Miron, Masako Fujioka-Kobayashi, Yufeng Zhang, Anton Sculean, Benjamin Pippenger, Yoshinori Shirakata, Umadevi Kandalam, Maria Hernandez
OBJECTIVES: Dimensional changes of the alveolar bone following tooth extraction are a major challenge in daily dental practice. To limit bone loss, a variety of biomaterials including bone grafts, barrier membranes, and growth factors have been utilized either alone or in combination therapies to increase the speed and quality of new bone formation. The aim of the present in vitro study was to investigate the regenerative potential of Osteogain®, a new liquid carrier system of enamel matrix derivative (EMD) in combination with an absorbable collagen sponge (ACS) specifically designed for extraction socket healing...
December 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27907861/in-situ-time-lapse-study-of-extracellular-polymeric-substance-discharge-in-streptococcus-mutans-biofilm
#4
Bernard Haochih Liu, Li-Chieh Yu
Streptococcus mutans is one of the main pathogens that cause tooth decay. By metabolizing carbohydrates, S. mutans emits extracellular polymeric substance (EPS) that adheres to the tooth surface and forms layers of biofilm. Periodontal disease occurs due to the low pH environment created by S. mutans biofilm, and such an acidic environment gradually erodes tooth enamel. Since the existence of EPS is essential in the formation of biofilm, the in-situ investigation of its generation and distribution in real time is the key to the control and suppression of S...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27900252/the-rarest-cause-of-impaction-of-mandibular-third-molar-a-case-report
#5
Chandresh Jaiswara, Alka Rani, Neeraj Kumar Dhiman
Mandibular tooth impaction is a very common finding and is usually associated with so many local and systemic causes in which the pathway of tooth eruption is obstructed or misdirected. The local causes are either a local bony lesion or an abnormal position of the adjacent tooth. The case presented here is associated with a very rare cause of impaction, which is the hamartomatus growth of the first and second molars causing the obstruction and leading to the impaction of the adjacent third molar tooth.
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27895972/genetic-basis-of-nonsyndromic-and-syndromic-tooth-agenesis
#6
REVIEW
Xiaoqian Ye, Ali B Attaie
Human dentition development is a long and complex process which involves a series of reciprocal and sequential interactions between the embryonic stomodeal epithelium and the underlying neural crest-derived mesenchyme. Despite environment disturbances, tooth development is predominantly genetically controlled. To date, more than 200 genes have been identified in tooth development. These genes implied in various signaling pathways such as the bone morphogenetic protein, fibroblast growth factor, sonic hedgehog homolog, ectodysplasin A, wingless-type MMTV integration site family (Wnt), and transform growth factor pathways...
December 2016: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/27883224/basic-fibroblast-growth-factor-regulates-rex1-expression-via-il-6-in-stem-cells-isolated-from-human-exfoliated-deciduous-teeth
#7
Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Thanaphum Osathanon
Basic fibroblast growth factor (bFGF) regulates pluripotent marker expression and cellular differentiation in various cell types. However, the mechanism by which bFGF regulates REX1 expression in stem cells isolated from human exfoliated deciduous teeth (SHEDs) remains unclear. The aim of the present study was to investigate the regulation of REX1 expression by bFGF in SHEDs. SHEDs were isolated and characterized. Their mRNA and protein expression levels were determined using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively...
November 24, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27882508/regional-early-development-and-eruption-of-permanent-teeth-case-report
#8
A M Al Mullahi, A Bakathir, S Al Jahdhami
BACKGROUND: Early development and eruption of permanent teeth are rarely reported in scientific literature. Early eruption of permanent teeth has been reported to occur due to local factors such as trauma or dental abscesses in primary teeth, and in systemic conditions. Congenital diffuse infiltrating facial lipomatosis (CDIFL) is a rare condition that belongs to a group of lipomatosis tumours. In this disorder, the mature adipocytes invade adjacent soft and hard tissues in the facial region...
November 23, 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27872325/the-molecular-circuit-regulating-tooth-development-in-crocodilians
#9
S Tsai, A Abdelhamid, M K Khan, A Elkarargy, R B Widelitz, C M Chuong, P Wu
Alligators have robust regenerative potential for tooth renewal. In contrast, extant mammals can either renew their teeth once (diphyodont dentition, as found in humans) or not at all (monophyodont dentition, present in mice). Previously, the authors used multiple mitotic labeling to map putative stem cells in alligator dental laminae, which contain quiescent odontogenic progenitors. The authors demonstrated that alligator tooth cycle initiation is related to β-catenin/Wnt pathway activity in the dental lamina bulge...
December 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27854158/impact-of-erecta-mutation-on-leaf-serration-differs-between-arabidopsis-accessions
#10
Toshiaki Tameshige, Satoshi Okamoto, Masao Tasaka, Keiko U Torii, Naoyuki Uchida
Serration or teeth of plant leaves is a morphological trait regulated genetically and environmentally. Very recently, it has been reported that the receptor kinases encoded by three ERECTA (ER)-family genes, ER, ER-LIKE1 (ERL1) and ERL2, redundantly play a role in tooth growth in Arabidopsis thaliana. In the report, Columbia (Col) accession was used for analyses, where none of the signal mutant of the ER-family genes exhibited serration defects. The toothless, smooth leaf margin phenotype was evident only when two out of the three ER-family genes were lost...
November 17, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27847749/comparative-assessment-of-antibacterial-activity-of-different-glass-ionomer-cements-on-cariogenic-bacteria
#11
Rahul Gaybarao Naik, Arun Suresh Dodamani, Mahesh Ravindra Khairnar, Harish Chaitram Jadhav, Manjiri Abhay Deshmukh
OBJECTIVES: Glass ionomer cements (GICs), which are biocompatible and adhesive to the tooth surface, are widely used nowadays for tooth restoration. They inhibit the demineralization and promote the remineralization of the tooth structure adjacent to the restoration, as well as interfere with bacterial growth. Hence, the present study was conducted to assess and compare the antimicrobial activity of three commercially available GICs against two cariogenic bacteria. MATERIALS AND METHODS: An agar plate diffusion test was used for evaluating the antimicrobial effect of three different GICs (Fuji IX, Ketac Molar, and d-tech) on Streptococcus mutans (S...
November 2016: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/27836805/cementum-structure-in-beluga-whale-teeth
#12
S R Stock, L A Finney, A Telser, E Maxey, S Vogt, J S Okasinski
: A large fraction of the volume of Beluga whale (Delphinapterus leucas) teeth consists of cementum, a mineralized tissue which grows throughout the life of the animal and to which the periodontal ligaments attach. Annular growth bands or growth layer groups (GLGs) form within Beluga cementum, and this study investigates GLG structure using x-ray fluorescence mapping and x-ray diffraction mapping with microbeams of synchrotron radiation. The Ca and Zn fluorescent intensities and carbonated hydroxyapatite (cAp) diffracted intensities rise and fall together and match the light-dark bands visible in transmitted light micrographs...
November 8, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27833148/igf-1-igf-1r-hsa-let-7c-axis-regulates-the-committed-differentiation-of-stem-cells-from-apical-papilla
#13
Shu Ma, Genxia Liu, Lin Jin, Xiyao Pang, Yanqiu Wang, Zilu Wang, Yan Yu, Jinhua Yu
Insulin-like growth factor-1 (IGF-1) and its receptor IGF-1R play a paramount role in tooth/bone formation while hsa-let-7c actively participates in the osteogenic differentiation of mesenchymal stem cells. However, the interaction between IGF-1/IGF-1R and hsa-let-7c on the committed differentiation of stem cells from apical papilla (SCAPs) remains unclear. In this study, human SCAPs were isolated and treated with IGF-1 and hsa-let-7c over/low-expression viruses. The odonto/osteogenic differentiation of these stem cells and the involvement of mitogen-activated protein kinase (MAPK) pathway were subsequently investigated...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27825708/is-non-operative-management-of-childhood-neurologic-cavovarus-foot-effective
#14
H d'Astorg, V Rampal, R Seringe, C Glorion, P Wicart
INTRODUCTION: Neurologic pes cavus is a progressive deformity that is difficult to treat during growth. The present study reports results of non-operative management, based on the pathophysiology of the deformity, by untwisting nocturnal splint, preceded in some cases by untwisting walking cast. The objective was to assess efficacy and impact on indications for surgery. METHOD: Twenty-three children (35 feet) were included. All had neurologic cavovarus foot, which was progressive in 24 feet (69%) (Charcot-Marie-Tooth disease)...
December 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27824330/effect-of-sustained-pdgf-non-viral-gene-delivery-on-repair-of-tooth-supporting-bone-defects
#15
A B Plonka, B Khorsand, N Yu, J V Sugai, A K Salem, W V Giannobile, S Elangovan
Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) promotes soft tissue and bone healing, and is FDA-approved for treatment of diabetic ulcers and periodontal defects. The short half-life of topical rhPDGF-BB protein application necessitates bolus, high-dose delivery. Gene therapy enables sustained local growth factor production. A novel gene activated matrix delivering polyplexes of polyethylenimine (PEI)-plasmid DNA (pDNA) encoding PDGF was evaluated for promotion of periodontal wound repair in vivo...
November 8, 2016: Gene Therapy
https://www.readbyqxmd.com/read/27822241/surgical-management-of-extensive-oral-tumors-by-bilateral-rostral-mandibulectomy-in-two-dogs
#16
M Shafiuzama, M S Sabarish Babu, N Krishnaveni, P Manoj Prabhakar, S Hemalatha, N J D Souza
Two dogs of different age groups were presented with the history of oral growth, bleeding, excessive salivation, bad breath, inappetance and dysphagia. Physical examination revealed cauliflower like reddish growth in the gingiva enclosing the mandibular incisiors and canine tooth. Haematology and serum biochemical profiles were within the normal range. Plain radiography revealed extensive growth involving the lower mandible and gingiva. Hence rostral mandibulectomy was performed to excise the tumor mass. The dogs recovered uneventfully after surgery with no difficulty in feeding liquid and semisolid diet...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27817004/a-combined-epithelial-odontogenic-tumor-a-7-year-follow-up-case
#17
Ana Cláudia Garcia Rosa, Andresa Borges Soares, Cristiane Furuse, Sandro Régis Rodrigues Lima, Vera Cavalcanti de Araújo, Fabricio Passador-Santos
Adenomatoid odontogenic tumor (AOT) is a benign epithelial odontogenic tumor characterized by slow and progressive growth. When central lesions are associated with an unerupted permanent tooth, they are also known as the follicular type. Histological variants of AOT may complicate diagnosis with possible adverse effects on treatment and prognosis. The aim of this study is to report a case of a follicular AOT with extensive calcifying epithelial odontogenic tumor (CEOT)-like histopathological areas in the anterior region of the mandible that was treated by enucleation...
November 5, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27794150/periodontal-and-microbiological-profile-of-intensive-care-unit-inpatients
#18
Alessandra N Porto, Alvaro H Borges, Grace Rocatto, Fernanda Z Matos, Alexandre M Borba, F L Miranda Pedro, Suellen L Lima, Mateus R Tonetto, Matheus C Bandéca, A M Fabio Aranha
INTRODUCTION: The bidirectional relationship between the periodontal diseases and systemic diseases was attributed to the focal infection concept. The aims of this study were to assess the periodontal and microbiological profile of intensive care unit (ICU) inpatients submitted to orotracheal intubation, and classify them regarding gender, age group, ethnic, hospitalization reason and period, nosocomial infection occurrence, and death. MATERIALS AND METHODS: Inpatients were assessed, distributed into toothed and toothless groups...
October 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27790596/epithelial-mesenchymal-interactions-in-tooth-development-and-the-significant-role-of-growth-factors-and-genes-with-emphasis-on-mesenchyme-a-review
#19
REVIEW
Jaya Sekharan Vannadil Puthiyaveetil, Kasim Kota, Roopesh Chakkarayan, Jithesh Chakkarayan, Abdul Kabeer Padinhare Thodiyil
The recent advancements in medical research field mainly highlights the genetic and molecular aspects of various disease processes and related treatment options, in a specialized "custom-made" approach. The medical and dental field has made tremendous progress in providing even with the smallest insight into pathological entities, thus, making patient management more fruitful. But, short comings have occurred in dental treatments involving odontogenic lesions mainly due to poor understanding of the developmental cycle involved during early stages of developmental process...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27780691/regeneration-of-a-tooth-in-a-tissue-engineered-mandible-after-resection-of-a-central-giant-cell-tumor-demonstrating-evidence-of-functional-matrix-theory-and-ectodermal-origin-of-teeth-in-a-human-model-a-case-report
#20
James C Melville, Marcus A Couey, Matthew S Tong, Robert E Marx
Central giant cell tumors (CGCTs) are uncommon lesions occurring in the jaw. They are benign but locally destructive osteolytic lesions. They usually occur in pediatric patients 5 to 15 years of age. Multiple noninvasive modalities of treatment (intralesional steroids, interferon, calcitonin, and denosumab) have been described for those lesions, but for those that are refractory to treatment, enucleation and curettage or resection is a curative surgery. This case report describes a pediatric patient who was diagnosed with an aggressive CGCT of the left mandible encompassing the right angle to the condyle...
September 29, 2016: Journal of Oral and Maxillofacial Surgery
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