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https://www.readbyqxmd.com/read/28454466/identification-of-molecular-characteristics-induced-by-radiotherapy-in-rectal-cancer-based-on-microarray-data
#1
Chang Ge, Mengxia Wu, Guifang Chen, Guanying Yu, Dehui Ji, Shaozhao Wang
The present study aimed to reveal the molecular characteristics induced by radiotherapy in rectal cancer at the transcriptome level. Microarray data (ID, GSE26027) downloaded from the Gene Expression Omnibus database were re-analyzed to identify differentially expressed genes (DEGs) between rectal cancer tissues during and prior to radiotherapy. The DEGs were then inputted into the database for annotation, visualization and integrated discovery, an online tool to perform enrichment analyses, and into the search tool for the retrieval of interacting genes/proteins database to identify protein-protein interactions (PPIs)...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454310/downregulation-of-lkb1-promotes-tumor-progression-and-predicts-unfavorable-prognosis-in-patients-with-glioma
#2
Jiehao Huang, Hongwu Chen, Quantang Wei, Ziheng Zhang, Zhiwei Zhong, Yimin Xu
The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were performed. The present study demonstrated that LKB1 expression was markedly decreased at the messenger RNA and protein levels in 30 freshly prepared glioma tissues, compared with non-neoplastic brain tissues (P<0...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454301/immunohistochemical-profile-of-ing3-protein-in-normal-and-cancerous-tissues
#3
Wen-Feng Gou, Xue-Feng Yang, Dao-Fu Shen, Shuang Zhao, Hong-Zhi Sun, Jun-Sheng Luo, Hua-Chuan Zheng
The inhibitor of growth family, member 3 (ING3) protein may be capable of blocking the cell cycle via activating p53-transactivated promoters of p21 and Bcl2-associated X protein, and may induce apoptosis via a Fas/caspase-8-dependent signaling pathway. In the present study, immunohistochemistry was performed in order to characterize the expression profile of ING3 protein in tissue microarrays containing mouse and human normal tissue, human hepatocellular (n=62), renal clear cell (n=62), pancreatic (n=62), esophageal squamous cell (n=45), cervical squamous cell (n=31), breast (n=144), gastric (n=196), colorectal (n=96), ovarian (n=208), endometrial (n=96) and lung carcinoma (n=192)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454256/high-expression-of-mmp9-in-glioma-affects-cell-proliferation-and-is-associated-with-patient-survival-rates
#4
Qiang Xue, Li Cao, Xiao-Yan Chen, Jing Zhao, Liang Gao, San-Zhong Li, Zhou Fei
Human gliomas are a heterogeneous group of primary malignant brain tumors, which most commonly occur in the central nervous system of children and adults. Previous studies have suggested a prognostic role of matrix metalloproteinase 9 (MMP9) in glioma, however, the frequency and significance of the protein expression of MMP9 in glioma remain to be fully elucidated. In the present study, the expression of MMP9 was detected by reverse transcription-quantitative polymerase chain reaction (qPCR), western blotting and immunohistochemical staining...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453753/effects-of-commercial-organic-acid-blends-on-male-broilers-challenged-with-e-%C3%A2-coli-k88-performance-microbiology-intestinal-morphology-and-immune-response
#5
N Khodambashi Emami, A Daneshmand, S Zafari Naeini, E N Graystone, L J Broom
This study assessed the effects of 3 commercial organic acid (OA) preparations on growth performance, intestinal morphology, cecal microbiology, and immunity of Escherichia coli K88-challenged (ETEC) broiler chickens. One thousand one-day-old male broiler chickens were divided into 8 treatments of 5 replicate pens: Negative control (NC) birds received a basal diet (BD) and were not challenged with ETEC; positive control (PC) birds fed the BD and challenged with ETEC; BD + 0.2% (S1) or 0.4% (S2) of an OA mixture (Salkil) from one to 35 d; BD + 0...
April 26, 2017: Poultry Science
https://www.readbyqxmd.com/read/28453444/electrode-distance-regulates-the-anodic-growth-of-titanium-dioxide-tio-sub-2-sub-nanotubes
#6
Rong Fan, Jiandi Wan
Electrochemical anodization of titanium has been used widely to produce self-organized TiO<sub>2</sub> nanotube arrays. Many experimental parameters such as anodizing voltage and electrolyte composition have been investigated extensively in the anodic growth of TiO<sub>2</sub> nanotubes. The effect of electrode distance on the anodic growth of TiO<sub>2</sub> nanotube arrays, however, remains elusive. This could be an important problem when in situ growth of TiO<sub>2</sub> nanotubes is required in microdevices...
April 28, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28449243/pathologic-features-of-mycobacteriosis-in-naturally-infected-syngnathidae-and-novel-transcriptome-assembly-in-association-with-disease
#7
S B Fogelson, M D Fast, J Leary, A C Camus
Syngnathidae (seahorses, seadragons and pipefish) suffer significant losses from non-tuberculous mycobacteria. However, they produce markedly different lesions in response to the disease compared to other teleost species, notably infrequent granuloma formation. This study evaluated 270 syngnathid fish, from which 92 were diagnosed with mycobacteriosis by histopathology, culture or both. Microscopic lesions variably consisted of random foci of coagulative necrosis in multiple organs, containing high numbers of free bacteria and large aggregates or sheets of macrophages with cytoplasm laden with acid-fast bacilli...
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#8
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448906/variation-in-the-toxicity-of-sediment-associated-substituted-phenylamine-antioxidants-to-an-epibenthic-hyalella-azteca-and-endobenthic-tubifex-tubifex-invertebrate
#9
R S Prosser, A J Bartlett, D Milani, E A M Holman, H Ikert, D Schissler, J Toito, J L Parrott, P L Gillis, V K Balakrishnan
Substituted phenylamine antioxidants (SPAs) are produced in relatively high volumes and used in a range of applications (e.g., rubber, polyurethane); however, little is known about their toxicity to aquatic biota. Therefore, current study examined the effects of chronic exposure (28 d) to four sediment-associated SPAs on epibenthic (Hyalella azteca) and endobenthic (Tubifex tubifex) organisms. In addition, acute (96-h), water-only exposures were conducted with H. azteca. Mortality, growth and biomass production were assessed in juvenile H...
April 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448867/immuno-modulatory-and-cellular-antioxidant-activities-of-%C3%AE%C2%BA-selenocarrageenan-in-combination-with-epirubicin-in-h22-hepatoma-bearing-mice
#10
Na Ling, Xiaojun Zhou, Yubin Ji, Wenlan Li, Chenfeng Ji, Zheng Qi
BACKGROUND: Human hepatocellular carcinoma (HCC) has a high rate of tumor recurrence and metastasis, resulting in shortened survival time. The aim of this study is to evaluate the synergistic anti-tumor effects and underlying mechanism of κ-selenocarrageenan (KSC) in combination with the chemotherapy drug epirubicin (EPI) in H22 tumor-bearing mice. METHODS: Hepatocellular carcinoma H22 cells were implanted into mice. After the transplants were successfully established, the animals were divided into four groups: namely the control group, the KSC group, the EPI group and the KSC+EPI group...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448840/a-cocktail-of-volatile-compounds-emitted-from-alcaligenes-faecalis-jbcs1294-induces-salt-tolerance-in-arabidopsis-thaliana-by-modulating-hormonal-pathways-and-ion-transporters
#11
Dipto Bhattacharyya, Yong Hoon Lee
In our previous study we showed that volatile organic compounds (VOCs) from Alcaligenes faecalis JBCS1294 (JBCS1294) induced tolerance to salt stress in Arabidopsis thaliana by influencing the auxin and gibberellin pathways and upregulating the expression of key ion transporters. The aim of this study was to evaluate the contribution of each VOC and blends of the VOCs on the induction of salt tolerance and signaling pathways. The key VOCs emitted from JBCS1294 were dissolved in lanolin and applied to one side of bipartite I-plates that contained Arabidopsis seeds on Murashige and Skoog (MS) media supplemented with NaCl on the other side...
April 12, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28448785/a-class-ii-myosin-is-required-for-growth-conidiation-cell-wall-integrity-and-pathogenicity-of-magnaporthe-oryzae
#12
Min Guo, Leyong Tan, Xiang Nie, Zhengguang Zhang
In eukaryotic organisms, myosin proteins are the major ring components that are involved in cytokinesis. To date, little is known about the biological functions of myosin proteins in Magnaporthe oryzae. In this study, insertional mutagenesis conducted in M. oryzae led to identification of Momyo2, a pathogenicity gene predicted to encode a class-II myosin protein homologous to Saccharomyces cerevisiae Myo1. According to qRT-PCR, Momyo2 is highly expressed during early infectious stage. When this gene was disrupted, the resultant mutant isolates were attenuated in virulence on rice and barley...
April 27, 2017: Virulence
https://www.readbyqxmd.com/read/28448619/pyridoxal-phosphate-synthases-pdxs-pdxt-are-required-for-actinobacillus-pleuropneumoniae-viability-stress-tolerance-and-virulence
#13
Fang Xie, Gang Li, Yalei Wang, Yanhe Zhang, Long Zhou, Chengcheng Wang, Shuanghong Liu, Siguo Liu, Chunlai Wang
Pyridoxal 5'-phosphate (PLP) is an essential cofactor for numerous enzymes involved in a diversity of cellular processes in living organisms. Previous analysis of the Actinobacillus pleuropneumoniae S-8 genome sequence revealed the presence of pdxS and pdxT genes, which are implicated in deoxyxylulose 5-phosphate (DXP)-independent pathway of PLP biosynthesis; however, little is known about their roles in A. pleuropneumoniae pathogenicity. Our data demonstrated that A. pleuropneumoniae could synthesize PLP by PdxS and PdxT enzymes...
2017: PloS One
https://www.readbyqxmd.com/read/28448560/activity-of-xyloglucan-endotransglucosylases-hydrolases-suggests-a-role-during-host-invasion-by-the-parasitic-plant-cuscuta-reflexa
#14
Stian Olsen, Kirsten Krause
The parasitic vines of the genus Cuscuta form haustoria that grow into other plants and connect with their vascular system, thus allowing the parasite to feed on its host. A major obstacle that meets the infection organ as it penetrates the host tissue is the rigid plant cell wall. In the present study, we examined the activity of xyloglucan endotransglucosylases/hydrolases (XTHs) during the host-invasive growth of the haustorium. The level of xyloglucan endotransglucosylation (XET) activity was found to peak at the penetrating stage of Cuscuta reflexa on its host Pelargonium zonale...
2017: PloS One
https://www.readbyqxmd.com/read/28448559/hexa-is-a-versatile-regulator-involved-in-the-control-of-phenotypic-heterogeneity-of-photorhabdus-luminescens
#15
Angela Langer, Adriana Moldovan, Christian Harmath, Susan A Joyce, David J Clarke, Ralf Heermann
Phenotypic heterogeneity in microbial communities enables genetically identical organisms to behave differently even under the same environmental conditions. Photorhabdus luminescens, a bioluminescent Gram-negative bacterium, contains a complex life cycle, which involves a symbiotic interaction with nematodes as well as a pathogenic association with insect larvae. P. luminescens exists in two distinct phenotypic cell types, designated as the primary (1°) and secondary (2°) cells. The 1° cells are bioluminescent, pigmented and can support nematode growth and development...
2017: PloS One
https://www.readbyqxmd.com/read/28448484/tissue-engineered-3d-human-lymphatic-microvascular-network-for-in-vitro-studies-of-lymphangiogenesis
#16
Laure Gibot, Todd Galbraith, Jennifer Bourland, Anita Rogic, Mihaela Skobe, François A Auger
This protocol describes a unique in vitro method for the generation of a 3D human lymphatic network within native connective tissue devoid of any exogenous material such as scaffolds or growth factors. In this five-stage protocol, human lymphatic endothelial cells (LECs) cocultured with dermal fibroblasts spontaneously organize into a stable 3D lymphatic capillary network. Stage 1 involves the isolation of primary fibroblasts and LECs from human skin. Fibroblasts are then cultured to produce connective tissue rich in extracellular matrix (stage 2), onto which LECs are seeded to form a network (stage 3)...
May 2017: Nature Protocols
https://www.readbyqxmd.com/read/28448328/hospice-or-community-network-choices-in-end-of-life-care-in-jamaica
#17
Roger Lee Mendoza
AIM: National and international healthcare agencies and organizations typically attribute slow or haphazard growth in hospice and palliative care in developing countries to various resource constraints. This study provides evidence of the substantial and widening gap between policy advocacy and individual decision-making concerning end-of-life care. It does so by establishing the incentives and risks that underlie choices of patients and providers against the relative scarcity of hospices in these countries...
April 26, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28448276/white-light-emission-of-monolithic-ingan-gan-grown-on-morphology-controlled-nanostructured-gan-templates
#18
Keun Man Song, Do Hyun Kim, Jong Min Kim, Chu-Young Cho, Jehyuk Choi, Ka Hee Kim, Jinsub Park, Hogyoung Kim
We demonstrated an InGaN/GaN-based, monolithic, white light-emitting diode (LED) without phosphors by using morphology-controlled active layers formed on multi-facet GaN templates containing polar and semipolar surfaces. The nanostructured surface morphology was controlled by changing the growth time, and distinct multiple photoluminescence peaks were observed at 360, 460, and 560 nm; these features were caused by InGaN/GaN-based multiple quantum wells (MQWs) on the nanostructured facets. The origin of each multi-peak was related to the different indium (In) compositions in the different planes of the quantum wells grown on the nanostructured GaN...
April 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28448201/cellular-polyamines-modulate-mrna-stability
#19
Haoxi Chai, Wannian Yang, Huazhong Shi
Polyamines (PAs) are polycationic compounds found in all living organisms and play crucial roles in growth and survival. PAs interact with and modulate the functions of anionic macromolecules such as DNA, RNA and proteins. LHR1/PUT3 is a polyamine influx transporter localized in the plasma membrane in Arabidopsis. In our recent paper in The Plant Journal, (1) we demonstrated that LHR1/PUT3 has a pivotal role in stabilizing the mRNAs of several important heat stress responsive genes under high temperature. In this short communication, we discuss about a putative pathway for modulating the PUT3 transport activity and the significance of evolutionary variations in PUT3 in Arabidopsis...
April 27, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28448112/real-time-imaging-of-2d-and-3d-temperature-distribution-coating-of-metal-ion-intercalated-organic-layered-composites-with-tunable-stimuli-responsive-properties
#20
Machi Takeuchi, Hiroaki Imai, Yuya Oaki
Organic layered materials have intercalation and dynamic properties. The dynamic properties are tuned by the intercalation of the guests. In general, howevver, it is not easy to achieve homogeneous and thin coating of the layered materials on substrates with complex shapes because of the two-dimentional anisotropic structures. In the present work, the layered organic composites were homogeneously coated on a variety of substrates for application to practical devices. The metal-ion-intercalated layered polydiacetylene (PDA-Mn+) with tunable stimuli-responsive color-change properties was coated on substrates, such as paper and cotton consisting of cellulose fibers...
April 27, 2017: ACS Applied Materials & Interfaces
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