keyword
MENU ▼
Read by QxMD icon Read
search

MCAS

keyword
https://www.readbyqxmd.com/read/29912902/enhancement-of-bradykinin-induced-relaxation-by-focal-brain-ischemia-in-the-rat-middle-cerebral-artery-receptor-expression-upregulation-and-activation-of-multiple-pathways
#1
Youhai Li, Natalia Lapina, Nina Weinzierl, Lothar Schilling
Focal brain ischemia markedly affects cerebrovascular reactivity. So far, these changes have mainly been related to alterations in the level of smooth muscle cell function while alterations of the endothelial lining have not yet been studied in detail. We have, therefore, investigated the effects of ischemia/reperfusion injury on bradykinin (BK)-induced relaxation since BK is an important mediator of tissue inflammation and affects vascular function in an endothelium-dependent manner. Focal brain ischemia was induced in rats by endovascular filament occlusion (2h) of the middle cerebral artery (MCA)...
2018: PloS One
https://www.readbyqxmd.com/read/29905843/srna-dependent-control-of-curli-biosynthesis-in-escherichia-coli-mcas-directs-endonucleolytic-cleavage-of-csgd-mrna
#2
Patrick Rosendahl Andreassen, Jens Sivkær Pettersen, Mateusz Szczerba, Poul Valentin-Hansen, Jakob Møller-Jensen, Mikkel Girke Jørgensen
Production of curli, extracellular protein structures important for Escherichia coli biofilm formation, is governed by a highly complex regulatory mechanism that integrates multiple environmental signals through the involvement of numerous proteins and small non-coding RNAs (sRNAs). No less than seven sRNAs (McaS, RprA, GcvB, RydC, RybB, OmrA and OmrB) are known to repress the expression of the curli activator CsgD. Many of the sRNAs repress CsgD production by binding to the csgD mRNA at sites far upstream of the ribosomal binding site...
June 14, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29859444/monocarboxylic-and-dicarboxylic-acids-over-oceans-from-the-east-china-sea-to-the-arctic-ocean-roles-of-ocean-emissions-continental-input-and-secondary-formation
#3
Qihou Hu, Zhouqing Xie, Xinming Wang, Hui Kang, Yuqing Zhang, Xiang Ding, Pengfei Zhang
Organic acids are major components in marine organic aerosols. Many studies on the occurrence, sources and sinks of organic acids over oceans in the low and middle latitudes have been conducted. However, the understanding of relative contributions of specific sources to organic acids over oceans, especially in the high latitudes, is still inadequate. This study measured organic acids, including C14:0 - C32:0 saturated monocarboxylic acids (MCAs), C16:1 , C18:1 and C18:2 unsaturated MCAs, and di-C4 - di-C10 dicarboxylic acids (DCAs), in the marine boundary layer from the East China Sea to the Arctic Ocean during the 3rd Chinese Arctic Research Expedition (CHINARE 08)...
May 30, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29846722/proximal-parent-vessel-tapering-is-associated-with-aneurysm-at-the-middle-cerebral-artery-bifurcation
#4
Alexandra Lauric, Kilian Greim-Kuczewski, Alexei Antonov, Gabriel Dardik, Jane K Magida, James E Hippelheuser, Kenichi Kono, Adel M Malek
BACKGROUND: Cerebral aneurysm initiation and evolution have been linked to hemodynamic and morphological factors. Stenotic morphology upstream to a bifurcation can alter hemodynamic patterns and lead to destructive vessel wall remodeling and aneurysm initiation. The effect of more subtle proximal variations in vessel diameter on bifurcation aneurysm development has not been evaluated. OBJECTIVE: To investigate whether vessel tapering is associated with aneurysmal presence at the middle cerebral artery (MCA) bifurcation...
May 26, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29775150/computer-aided-analysis-of-middle-cerebral-artery-tortuosity-association-with-aneurysm-development
#5
Kornelia M Kliś, Roger M Krzyżewski, Borys M Kwinta, Krzysztof Stachura, Marek Moskała, Krzysztof A Tomaszewski
OBJECTIVE Blood vessel tortuosity may play an important role in the development of vessel abnormalities such as aneurysms. Currently, however, there are no studies analyzing the impact of brain blood vessel tortuosity on the risk of aneurysm formation. Therefore, the authors performed a computer-aided analysis of middle cerebral artery (MCA) tortuosity, especially among patients diagnosed with MCA aneurysms. METHODS Anatomy of the MCAs of 54 patients with unruptured MCA aneurysms was retrospectively analyzed, as was that of 54 sex-, age-, and vessel side-matched control patients without MCA aneurysms...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29764279/the-modified-telephone-administered-minnesota-cognitive-acuity-screen-for-mild-cognitive-impairment
#6
Sarah Pillemer, George D Papandonatos, Cara Crook, Brian R Ott, Geoffrey Tremont
OBJECTIVE: This study aimed to compare the sensitivity and specificity of a modified version of the Minnesota Cognitive Acuity Screen (MCAS-m), by adding learning and recognition memory components, to the original version MCAS to distinguish amnestic mild cognitive impairment (aMCI) from healthy controls (HCs). METHODS/DESIGN: A total of 30 individuals with aMCI and 30 HCs underwent neuropsychological testing, neurologic examination, laboratory, and brain imaging tests...
January 1, 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29761419/measuring-geographic-migration-patterns-using-matr%C3%A3-culas-consulares
#7
Maria Esther Caballero, Brian C Cadena, Brian K Kovak
In this article, we show how to use administrative data from the Matrícula Consular de Alta Seguridad (MCAS) identification card program to measure the joint distribution of sending and receiving locations for migrants from Mexico to the United States. Whereas other data sources cover only a small fraction of source or destination locations or include only very coarse geographic information, the MCAS data provide complete geographic coverage of both countries, detailed information on migrants' sources and destinations, and a very large sample size...
May 14, 2018: Demography
https://www.readbyqxmd.com/read/29758591/mineralocorticoid-receptor-antagonism-prevents-obesity-induced-cerebral-artery-remodeling-and-reduces-white-matter-injury-in-rats
#8
Paulo Wagner Pires, Jonathon Lee McClain, Sebastian F Hayoz, Anne McLaren Dorrance
Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by high fat (HF) feeding from weaning. Aldosterone, or activation of the mineralocorticoid receptor (MR) causes cerebrovascular injury in lean hypertensive rats. We hypothesized that rats fed a HF diet would show inward middle cerebral artery (MCA) remodeling that could be prevented by MR antagonism. We further proposed that the cerebral artery remodeling would be associated with white mater injury...
May 14, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29624088/intrastate-variation-in-treatment-and-outcomes-of-out-of-hospital-cardiac-arrest
#9
Ryan A Coute, Theresa A Shields, James A Cranford, Sardar Ansari, Mahshid Abir, M Hakam Tiba, Robert Dunne, Brian O'Neil, Robert Swor, Robert W Neumar
OBJECTIVE: Our objective was to analyze and compare out-of-hospital cardiac arrest (OHCA) system of care performance and outcomes at the Medical Control Authority (MCA) level in the state of Michigan. We hypothesized that clinically and statistically significant variations in treatment and outcomes of OHCA exists within a single U.S. state. METHODS: We performed a retrospective, observational study of all non-traumatic EMS-treated OHCA from the state of Michigan CARES registry for 2014-2015...
April 6, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29620297/-mastcell-activation-syndrome
#10
Evangelia Passia, Peter Jandus
Mast cell activation syndrome (MCAS) encompasses a heterogeneous group of pathologies, which are characterized by the existence of clinical symptoms secondary to the systemic effects of mediators released by activated mast cells. MCAS-related symptoms may be mild, moderate, severe, or even life-threatening. Detailed knowledge of the pathogenesis and complexity of MCAS can help in the management and treatment of these patients.
April 4, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29550928/effect-of-vasopressin-induced-chronic-hyponatremia-on-the-regulation-of-the-middle-cerebral-artery-of-the-rat
#11
Marta Aleksandrowicz, Ewa Kozniewska
Vasopressin (arginine vasopressin, AVP) plays a crucial role in maintaining body fluid homeostasis. Excessive release of vasopressin can lead to hyponatremia. Changes in cerebral circulation during vasopressin-induced chronic hyponatremia are not elucidated. The present study has been designed to investigate the effect of chronic vasopressin-induced hyponatremia on the regulation of the tone of the middle cerebral artery (MCA) of the rat. Chronic hyponatremia was induced in vivo with the help of vasopressin, released continuously from subcutaneously implanted ALZET mini-osmotic pumps, and a liquid diet...
March 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29517867/-severe-mast-cell-activation-syndrome-in-a-15-year-old-patient-with-an-hypermobile-ehlers-danlos-syndrome
#12
S Daens, D Grossin, T Hermanns-Lê, D Peeters, D Manicourt
We report the history of a 15-year old patient with a hypermobile Ehlers-Danlos syndrome (hEDS) (his mother, his two brothers and his sister have the same phenotype as him). He suffers mainly from a severe mast cell activation syndrome (MCAS) with an overreaction of the skin to any kind of contact (water of the shower, clothes, bed sheets) but he has also fatigue, headaches, and rash. This impressive rash is exacerbated after the shower and he has the urge to rest («shower's sign»). We describe the MCAS and its easy, fast and very effective medication management, without any significant side effects as well as its frequent association with the hEDS...
February 2018: Revue Médicale de Liège
https://www.readbyqxmd.com/read/29480381/factors-associated-with-changes-in-community-ability-and-recovery-after-psychiatric-rehabilitation-a-retrospective-study
#13
Bhing-Leet Tan, Wai-Yee Ng, Jayson Sudhasan, Thomas Chng, Irene Mok, Jimmy Lee
One of the key goals of psychiatric rehabilitation is to return individuals with mental illnesses back into the community via restoration of the necessary skills. This retrospective study seeks to evaluate the factors associated with improvement in community functioning after a period of outpatient rehabilitation. 223 individuals enrolled into three broad rehabilitation groups-clinical, vocational and creative therapies/individual sessions-were included in this study. The Multnomah Community Ability Scale (MCAS) and Milestones of Recovery Scale (MORS) were used to evaluate each individual before and after the rehabilitation programme...
February 26, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29408405/cpmca-a-novel-metacaspase-gene-from-the-harmful-dinoflagellate-cochlodinium-polykrikoides-and-its-expression-during-cell-death
#14
Hui Wang, Bum Soo Park, Weol-Ae Lim, Jang-Seu Ki
Metacaspases (MCAs) are cysteine proteases that share sequence homology with caspases, and may play roles in programmed cell death (PCD). In the present study, we identified a novel MCA gene (CpMCA) from the red tide dinoflagellate Cochlodinium polykrikoides, and examined its molecular characteristics and gene expression in response to algicide-induced cell death. CpMCA cDNA is 1164 bp in length, containing a dinoflagellate spliced leader sequence (dinoSL), an 879-bp open reading frame (ORF), which codes for a 293-aa protein, and a poly (A) tail...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29402188/middle-childhood-attachment-strategies-validation-of-an-observational-measure
#15
Laura E Brumariu, Kathryn R Giuseppone, Kathryn A Kerns, Magali Van de Walle, Jean-François Bureau, Guy Bosmans, Karlen Lyons-Ruth
The purpose of this study was to assess behavioral manifestations of attachment in middle childhood, and to evaluate their relations with key theoretical correlates. The sample consisted of 87 children (aged 10-12 years) and their mothers. Dyads participated in an 8-min videotaped discussion of a conflict in their relationships, later scored with the Middle Childhood Attachment Strategies Coding System (MCAS) for key features of all child attachment patterns described in previous literature (secure, ambivalent, avoidant, disorganized-disoriented, caregiving/role-confused, hostile/punitive)...
February 5, 2018: Attachment & Human Development
https://www.readbyqxmd.com/read/29379105/developmental-maturation-and-alpha-1-adrenergic-receptors-mediated-gene-expression-changes-in-ovine-middle-cerebral-arteries
#16
Dipali Goyal, Ravi Goyal
The Alpha Adrenergic Signaling Pathway is one of the chief regulators of cerebrovascular tone and cerebral blood flow (CBF), mediating its effects in the arteries through alpha1-adrenergic receptors (Alpha1AR). In the ovine middle cerebral artery (MCA), with development from a fetus to an adult, others and we have shown that Alpha1AR play a key role in contractile responses, vascular development, remodeling, and angiogenesis. Importantly, Alpha1AR play a significant role in CBF autoregulation, which is incompletely developed in a premature fetus as compared to a near-term fetus...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347818/far-red-fluorescent-probe-for-imaging-of-vicinal-dithiol-containing-proteins-in-living-cells-based-on-a-pk-a-shift-mechanism
#17
Shengrui Zhang, Guojun Chen, Yuanyuan Wang, Qin Wang, Yaogang Zhong, Xiao-Feng Yang, Zheng Li, Hua Li
Vicinal dithiol-containing proteins (VDPs) play fundamental roles in intracellular redox homeostasis and are responsible for many diseases. In this work, we report a far-red fluorescence turn-on probe MCAs for VDPs exploiting the pKa shift of the imine functionality of the probe. MCAs is composed of a merocyanine Schiff base as the fluorescent reporter and a cyclic 1,3,2-dithiarsenolane as the specific ligand for VDPs. The imine pKa of MCAs is 4.8, and it exists predominantly in the Schiff base (SB) form at physiological pH...
February 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29335026/congenital-anomalies-in-neurofibromatosis-1-a-retrospective-register-based-total-population-study
#18
Jussi Leppävirta, Roope A Kallionpää, Elina Uusitalo, Tero Vahlberg, Minna Pöyhönen, Juha Peltonen, Sirkku Peltonen
BACKGROUND: Neurofibromatosis type 1 (NF1) is a dominantly inherited Rasopathy caused by mutations in the NF1 gene on chromosome 17. NF1 has been connected to congenital anomalies, e.g., in the skeletal and cardiovascular systems, but the overall incidence of anomalies is unknown. In this retrospective register-based total population study conducted in Finland, the congenital anomalies in NF1 were evaluated. METHODS: One thousand four hundred ten patients with NF1 were identified by searching the medical records related to inpatient and outpatient hospital visits of patients with an associated diagnosis for NF1 in 1987-2011...
January 15, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29332145/the-experiences-and-beliefs-of-older-people-in-scottish-very-sheltered-housing-about-using-multi-compartment-compliance-aids
#19
Derek Stewart, Kathrine Gibson Smith, Joan MacLeod, Alison Strath, Vibhu Paudyal, Katrina Forbes-McKay, Scott Cunningham, Katie MacLure
Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To describe experiences and beliefs surrounding very sheltered housing (VSH) residents' use of MCAs with emphasis on issues of personalisation, reablement, shared decision-making, independence and support...
April 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29326369/successful-treatment-of-postural-orthostatic-tachycardia-and-mast-cell-activation-syndromes-using-naltrexone-immunoglobulin-and-antibiotic-treatment
#20
Leonard B Weinstock, Jill B Brook, Trisha L Myers, Brent Goodman
A patient with severe postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS) received immunotherapy with low-dose naltrexone (LDN) and intravenous immunoglobulin (IVIg) and antibiotic therapy for small intestinal bacterial overgrowth (SIBO). A dramatic and sustained response was documented. The utility of IVIg in autoimmune neuromuscular diseases has been published, but clinical experience with POTS is relatively unknown and has not been reported in MCAS. As a short-acting mu-opioid antagonist, LDN paradoxically increases endorphins which then bind to regulatory T cells which regulate T-lymphocyte and B-lymphocyte production and this reduces cytokine and antibody production...
January 11, 2018: BMJ Case Reports
keyword
keyword
95074
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"