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https://www.readbyqxmd.com/read/28058990/restoration-of-the-response-of-the-middle-cerebral-artery-of-the-rat-to-acidosis-in-hyposmotic-hyponatremia-by-the-opener-of-large-conductance-calcium-sensitive-potassium-channels-bkca
#1
Marta Aleksandrowicz, Beata Dworakowska, Krzysztof Dolowy, Ewa Kozniewska
Hyposmotic hyponatremia (the decrease of extracellular concentration of sodium ions from 145 to 121 mM and the decrease of hyposmolality from 300 to 250 mOsm/kg H2O) impairs response of the middle cerebral artery (MCA) to acetylcholine and NO donor (S-nitroso-N-acetyl-DL-penicillamine). Since acidosis activates a similar intracellular signaling pathway, the present study was designed to verify the hypothesis that the response of the MCA to acidosis is impaired during acute hyposmotic hyponatremia due to abnormal NO-related signal transduction in vascular smooth muscle cells...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28057635/in-vivo-assessment-of-the-impact-of-regional-intracranial-atherosclerotic-lesions-on-brain-arterial-3d-hemodynamics
#2
C Wu, S Schnell, P Vakil, A R Honarmand, S A Ansari, J Carr, M Markl, S Prabhakaran
BACKGROUND AND PURPOSE: Intracranial atherosclerosis induces hemodynamic disturbance, which is not well-characterized, particularly in cerebral flow redistribution. We aimed to characterize the impact of regional stenotic lesions on intracranial hemodynamics by using 4D flow MR imaging. MATERIALS AND METHODS: 4D flow MR imaging was performed in 22 symptomatic patients (mean age, 68.4 ± 14.2 years) with intracranial stenosis (ICA, n = 7; MCA, n = 9; basilar artery, n = 6) and 10 age-appropriate healthy volunteers (mean age, 60...
January 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28032649/kras-mutation-coupled-with-p53-loss-is-sufficient-to-induce-ovarian-carcinosarcomas-in-mice
#3
Feng-Hsiang Tang, Tsung-Hua Hsieh, Chia-Yi Hsu, Hsiao-Yun Lin, Cheng-Yu Long, Kuang-Hung Cheng, Eing-Mei Tsai
Ovarian carcinosarcoma cancer is the most lethal form of gynecological malignancy, but the pathogenesis and biological function for this ovarian cancer remain unknown. We establishment the transgenic mouse model of K-ras(G12D) p53(loxP/loxP) and found that K-ras mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology. Furthermore, double mutant ovaries formed ovarian carcinosarcomas that were high grade and poorly differentiated...
December 29, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28009450/multi-compartment-compliance-aids-in-the-community-the-prevalence-of-potentially-inappropriate-medications
#4
David Counter, Derek Stewart, Joan MacLeod, James S Mclay
AIMS: To assess the prevalence of potentially inappropriate medications (PIM) use in a population of community-based multi-compartment compliance aid (MCA) users in North- Scotland. METHODS: Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1(st) June to 31(st) October 2014, together with concurrently prescribed medications, patient demographics and Carstairs Index of social deprivation were recorded. Drug-specific quality indicators for PIMs from the Swedish National Board of Health and Welfare were applied and bivariate logistic regression analysis used to assess for associations with demographic variables...
December 23, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27956465/hfq-and-three-hfq-dependent-small-regulatory-rnas-mgrr-ryhb-and-mcas-coregulate-the-locus-of-enterocyte-effacement-in-enteropathogenic-escherichia-coli
#5
Shantanu Bhatt, Marisa Egan, Jasmine Ramirez, Christian Xander, Valerie Jenkins, Sarah Muche, Jihad El-Fenej, Jamie Palmer, Elisabeth Mason, Elizabeth Storm, Thomas Buerkert
Enteropathogenic Escherichia coli (EPEC) is a significant cause of infantile diarrhea and death in developing countries. The pathogenicity island locus of enterocyte effacement (LEE) is essential for EPEC to cause diarrhea. Besides EPEC, the LEE is also present in other gastrointestinal pathogens, most notably enterohemorrhagic E. coli (EHEC). Whereas transcriptional control of the LEE has been meticulously examined, posttranscriptional regulation, including the role of Hfq-dependent small RNAs, remains undercharacterized...
February 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/27927653/knockdown-of-add3-impairs-the-myogenic-response-of-renal-afferent-arterioles-and-middle-cerebral-arteries
#6
Fan Fan, Mallikarjuna R Pabbidi, Ying Ge, Longyang Li, Shaoxun Wang, Paige N Mims, Richard J Roman
We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA), and autoregulation of renal and cerebral blood flow are impaired in Fawn Hood Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing gamma-adducin (Add3) from Brown Norway rats rescues the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-art and MCA cultured for 36-hours using a 27-mer Dicer-substrate short interfering RNA (DsiRNA)...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27830888/morphometric-evaluation-of-the-delayed-cerebral-arteries-response-to-acetazolamide-test-in-patients-with-chronic-carotid-artery-stenosis-using-computed-tomography-angiography
#7
Arkadiusz Szarmach, Paweł J Winklewski, Grzegorz Halena, Mariusz Kaszubowski, Jarosław Dzierżanowski, Maciej Piskunowicz, Edyta Szurowska, Andrzej F Frydrychowski
BACKGROUND: The evidence accumulates that the response to acetazolamide test is delayed on the ipsilateral side to stenosis. However, the effect of acetazolamide beyond 30 minutes after acetazolamide administration remains unknown. The aim of this study was to assess the diameters of: anterior cerebral arteries (ACAs), middle cerebral arteries (MCAs) and posterior cerebral arteries (PCAs) before and 60 minutes after the acetazolamide test. MATERIALS AND METHODS: Seventeen patients with carotid artery stenosis ≥90% on the ipsilateral side and, ≤50% on the contralateral side were enrolled into the study...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27790241/improved-necker-cube-drawing-based-assessment-battery-for-constructional-apraxia-the-mie-constructional-apraxia-scale-mcas
#8
Masayuki Satoh, Chika Mori, Kana Matsuda, Yukito Ueda, Ken-Ichi Tabei, Hirotaka Kida, Hidekazu Tomimoto
BACKGROUND/AIMS: Constructional apraxia (CA) is usually diagnosed by having patients draw figures; however, the reported assessments only evaluate the drawn figure. We designed a new assessment battery for CA (the Mie Constructional Apraxia Scale, MCAS) which includes both the shape and drawing process, and investigated its utility against other assessment methods. METHODS: We designed the MCAS, and evaluated inter- and intrarater reliability. We also investigated the sensitivity, specificity, and positive and negative predictive values in dementia patients, and compared MCAS assessment with other reported batteries in the same subjects...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27789734/elevated-k-channel-activity-opposes-vasoconstrictor-response-to-serotonin-in-cerebral-arteries-of-the-fawn-hooded-hypertensive-rat
#9
Mallikarjuna R Pabbidi, Richard J Roman
Previous studies suggest that middle cerebral arteries (MCAs) of Fawn Hooded Hypertensive (FHH) rats exhibit impaired myogenic response and introgression of a small region of Brown Norway chromosome 1 containing 15 genes restored the response in FHH.1(BN) congenic rat. The impaired myogenic response in FHH rats is associated with an increase in the activity of the large conductance potassium (BK) channel in vascular smooth muscle cells (VSMCs). The present study examined whether the increased BK channel function in FHH rat alters vasoconstrictor response to serotonin (5-HT)...
January 1, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/27764837/effect-of-age-on-transcranial-doppler-velocities-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#10
Ivan R Da Silva, Joao A Gomes, Ari Wachsman, Gabriel Rodriguez de Freitas, Jose Javier Provencio
BACKGROUND: It is not well understood whether age impacts transcranial Doppler (TCD) mean flow velocities (MFVs) in patients with aneurysmal subarachnoid hemorrhage (SAH) with or without delayed cerebral ischemia (DCI). The aim of our study was to analyze the behavior of TCD MFV during the first 7 days after SAH in patients of different ages and correlate them with the occurrence of DCI. METHODS: This study is a databank analysis of patients with SAH admitted between 2010 and 2012 in a single center...
2016: European Neurology
https://www.readbyqxmd.com/read/27736719/cerebrovascular-dysfunction-following-subfailure-axial-stretch
#11
E David Bell, Anthony J Donato, Kenneth L Monson
Cerebral blood vessels are vital to maintaining the health of the brain. Traumatic brain injury (TBI) commonly results in autoregulatory dysfunction and associated failure of cerebral vessels to maintain homeostasis in the brain. While post-injury changes to brain biochemistry are known to contribute to this dysfunction, tissue deformation may also directly alter vascular smooth muscle cell (SMC) function. As a first step toward understanding stretch-induced dysfunction, this study investigates the effect of overstretch on the contractile behavior of SMCs in middle cerebral arteries (MCAs)...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27708675/uptake-of-the-medscheck-annual-medication-review-service-in-ontario-community-pharmacies-between-2007-and-2013
#12
Lisa Dolovich, Giulia Consiglio, Linda MacKeigan, Lusine Abrahamyan, Petros Pechlivanoglou, Valeria E Rac, Nedzad Pojskic, Elizabeth A Bojarski, Jiandong Su, Murray Krahn, Suzanne M Cadarette
BACKGROUND: MedsCheck Annual (MCA) is an Ontario government-funded medication review service for individuals taking 3 or more prescription medications for chronic conditions. METHODS: This cohort study analyzed linked administrative claims data from April 1, 2007, to March 31, 2013. Trends in MCA claims and recipient characteristics were examined. RESULTS: A total of 1,498,440 Ontarians (55% seniors, 55% female) received an MCA. One-third (36%) had 2 or more MCAs within 6 years...
September 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/27689730/development-of-resveratrol-curcumin-hybrids-as-potential-therapeutic-agents-for-inflammatory-lung-diseases
#13
Jialing Pan, Tingting Xu, Fengli Xu, Yali Zhang, Zhiguo Liu, Wenbo Chen, Weitao Fu, Yuanrong Dai, Yunjie Zhao, Jianpeng Feng, Guang Liang
Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. Resveratrol and curcumin are proven to have potent anti-inflammatory efficacy, but their clinical application is limited by their metabolic instability. Here, a series of resveratrol and the Mono-carbonyl analogs of curcumin (MCAs) hybrids were designed and synthesized by efficient aldol construction strategy, and then screened for anti-inflammatory activities in vitro and in vivo. The results showed that the majority of analogs effectively inhibited the LPS-induced production of IL-6 and TNF-α...
January 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27648320/flair-hyperintense-vessel-sign-of-both-mcas-with-severe-heart-failure
#14
Donghee Kim, Seung-Yul Lee, Kwon-Duk Seo
Introduction. Fluid-attenuated inversion recovery hyperintense vessels (FHVs) can be seen in patients with occlusion or severe stenosis of the cerebral arteries. FHVs are known to reflect stagnant or slow blood flow within the cerebral artery. Case Report. A 75-year-old woman presented with suddenly developed gait disturbance. She had a history of hypertension, heart failure, and dementia. Brain MRI demonstrated FHVs within both middle cerebral arteries (MCAs). However, there was no acute ischemic lesion and severe stenosis or occlusion of the cerebral arteries...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27588564/doca-salt-hypertension-impairs-artery-function-in-rat-middle-cerebral-artery-and-parenchymal-arterioles
#15
Nusrat Matin, Paulo W Pires, Hannah Garver, William F Jackson, Anne M Dorrance
OBJECTIVE: Chronic hypertension induces detrimental changes in the structure and function of surface cerebral arteries. Very little is known about PAs, which perfuse distinct neuronal populations in the cortex and may play a role in cerebrovascular disorders. We investigated the effect of DOCA-salt induced hypertension on endothelial function and artery structure in PAs and MCAs. METHODS: Uninephrectomized male Sprague-Dawley rats were implanted with a subcutaneous pellet containing DOCA (150 mg/kg b...
October 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/27582267/target-profiling-analyses-of-bile-acids-in-the-evaluation-of-hepatoprotective-effect-of-gentiopicroside-on-anit-induced-cholestatic-liver-injury-in-mice
#16
Xiaowen Tang, Qiaoling Yang, Fan Yang, Junting Gong, Han Han, Li Yang, Zhengtao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Gentiopicroside (GPS), one of iridoid glucoside representatives, is the most potential active component in Gentiana rigescens Franch. ex Hemsl and Gentiana macrophylla Pall. These two herbs have been used to treat jaundice and other hepatic and billiary diseases in traditional Chinese medicine for thousands of years. AIM OF THE STUDY: This study aimed to investigate the protective effects and mechanisms of GPS on α-naphthylisothiocyanate (ANIT) induced cholestatic liver injury in mice...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27544503/near-infrared-spectroscopy-and-transcranial-sonography-to-evaluate-cerebral-autoregulation-in-middle-cerebral-artery-steno-occlusive-disease
#17
Andreas Oldag, Jens Neumann, Michael Goertler, Hermann Hinrichs, Hans-Jochen Heinze, Andreas Kupsch, Catherine M Sweeney-Reed, Klaus Kopitzki
The measurement of autoregulatory delay by near-infrared spectroscopy (NIRS) has been proposed as an alternative technique to assess cerebral autoregulation, which is routinely assessed via transcranial Doppler sonography (TCD) in most centers. Comparitive studies of NIRS and TCD, however, are largely missing. We investigated whether cerebrovascular reserve (CVR), as assessed via TCD, correlates with the delay of the autoregulatory response to changes in arterial blood pressure (ABP) as assessed by NIRS, i...
November 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27538612/the-acute-effects-of-alcohol-on-cerebral-hemodynamic-changes-induced-by-the-head-up-tilt-test-in-healthy-subjects
#18
Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, Maria Tunde Magyar, Laszlo Csiba, Laszlo Olah
BACKGROUND: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects. METHODS: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27511128/the-leicester-cerebral-haemodynamics-database-normative-values-and-the-influence-of-age-and-sex
#19
Nikil Patel, Ronney B Panerai, Victoria Haunton, Emmanuel Katsogridakis, Nazia P Saeed, Angela Salinet, Fiona Brodie, Nazia Syed, Schnell D'Sa, Thompson G Robinson
Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex. Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously...
September 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27508665/-op-3c-05-characteristics-of-cerebral-hemodynamics-and-carotid-stiffness-in-patients-with-ischemic-leukoaraiosis-and-new-ultrasound-indices-of-ischemic-leukoaraiosis
#20
M Turk, M Zaletel, J Pretnar Oblak
OBJECTIVE: Leukoaraiosis (ILA) is believed to be ischaemic in origin due its association with cerebrovascular risk factors and similar location as lacunar infarctions. Its pathophysiology is not well understood and its diagnosis is still based on magnetic resonance imaging (MRI) as well as exclusion of other causes of white matter hyperintensities (WMH). So far there are no known confirming or screening diagnostic tests of ILA. Ultrasound studies have recently shown increased large artery stiffness, increased cerebrovascular resistance and lower cerebral blood flow in ILA patients...
September 2016: Journal of Hypertension
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