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https://www.readbyqxmd.com/read/29235088/middle-cerebral-artery-anatomical-variations-and-aneurysms-retrospective-study-based-on-computed-tomography-angiography-findings
#1
Paweł Brzegowy, Jakub Polak, Jakub Wnuk, Bartłomiej Łasocha, Jerzy Walocha, Tadeusz J Popiela
BACKGROUND: Anatomical variations of the middle cerebral artery (MCA) are an important clinical issue, due to high prevalence of intracranial aneurysms. Anatomical variations of vessels can lead to higher shear stress, which is thought to be the main factor leading to aneurysm formation and consequently to higher prevalence of aneurysms. The aim of this study was to evaluate anatomy of the MCA; to classify MCA aneurysms using CT angiography and to correlate anatomical variations of MCA and circle of Willis with prevalence of MCA aneurysms...
December 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29225779/risk-of-solid-cancer-in-patients-with-mast-cell-activation-syndrome-results-from-germany-and-usa
#2
Gerhard J Molderings, Thomas Zienkiewicz, Jürgen Homann, Markus Menzen, Lawrence B Afrin
Background:  It has been shown repeatedly that mast cells can promote or prevent cancer development and growth. If development and/or progression of a solid cancer is substantially influenced by mast cell activity, the frequencies of occurrence of solid cancers in patients with primary mast cells disorders would be expected to differ from the corresponding prevalence data in the general population. In fact, a recent study demonstrated that patients with systemic mastocytosis (i.e., a rare neoplastic variant of the primary mast cell activation disease) have increased risk for solid cancers, in particular melanoma and non-melanoma skin cancers...
2017: F1000Research
https://www.readbyqxmd.com/read/29215305/cerebrovascular-function-and-mitochondrial-bioenergetics-after-ischemia-reperfusion-in-male-rats
#3
Ibolya Rutkai, Ivan Merdzo, Sanjay V Wunnava, Genevieve T Curtin, Prasad Vg Katakam, David W Busija
The underlying factors promoting increased mitochondrial proteins, mtDNA, and dilation to mitochondrial-specific agents in male rats following tMCAO are not fully elucidated. Our goal was to determine the morphological and functional effects of ischemia/reperfusion (I/R) on mitochondria using electron microscopy, Western blot, mitochondrial oxygen consumption rate (OCR), and Ca2+ sparks activity measurements in middle cerebral arteries (MCAs) from male Sprague Dawley rats (Naïve, tMCAO, Sham). We found a greatly increased OCR in ipsilateral MCAs (IPSI) compared with contralateral (CONTRA), Sham, and Naïve MCAs...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29212100/lower-prevalence-of-vitamin-d-insufficiency-in-german-patients-with-systemic-mast-cell-activation-syndrome-compared-with-the-general-population
#4
Stefan Wirz, Hans-Jörg Hertfelder, Holger Seidel, Jürgen Homann, Gerhard J Molderings
Introduction The common mastocytosis variant systemic mast cell activation syndrome (MCAS) may underlie at least a subset of patients with irritable bowel syndrome (IBS). A critical role of vitamin D (VD) in the stabilization of mast cells (MCs) with deficiency of VD resulting in MC activation has been demonstrated. If so, supplementation of VD would be a potential therapeutic approach in the treatment of those IBS patients. Methods We investigated in the present study for the first time systematically whether the VD level in 100 MCAS patients differed from that in the German general population (Ggp) and made a first attempt to elucidate potential reasons for possible differences by simultaneously determining the blood levels of heparin and cholesterol...
December 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29194362/the-small-regulatory-rna-spot42-inhibits-indole-biosynthesis-to-negatively-regulate-the-locus-of-enterocyte-effacement-of-enteropathogenic-escherichia-coli
#5
Shantanu Bhatt, Valerie Jenkins, Elisabeth Mason, Sarah Muche
The locus of enterocyte effacement is necessary for enteropathogenic Escherichia coli (EPEC) to form attaching and effacing (A/E) lesions. A/E lesions are characterized by intimate bacterial adherence to intestinal cells and destruction of microvilli, which leads to diarrhea. Therefore, studies interrogating the regulation of the locus of enterocyte effacement (LEE) are critical for understanding the molecular epidemiology of EPEC infections and developing interventional strategies. Hitherto, most studies have centered on protein-based regulators, whereas the role of small regulatory RNAs remains underappreciated...
December 1, 2017: Microorganisms
https://www.readbyqxmd.com/read/29179622/traumatic-brain-injury-impairs-myogenic-constriction-of-cerebral-arteries-role-of-mitochondria-derived-h2o2-and-trpv4-dependent-activation-of-bkca-channels
#6
Nikolett Szarka, Mallikarjuna R Pabbidi, Krisztina Amrein, Endre Czeiter, Gergely Berta, Krisztina Pohoczky, Zsuzsanna Helyes, Zoltan Ungvari, Akos Koller, Andras Buki, Peter Toth
Traumatic brain injury (TBI) impairs autoregulation of cerebral blood flow, which contributes to the development of secondary brain injury increasing mortality of patients. Impairment of pressure-induced myogenic constriction of cerebral arteries plays a critical role in autoregulatory dysfunction; however, the underlying cellular and molecular mechanisms are not well understood. To determine the role of mitochondria-derived H2O2 and large-conductance calcium-activated potassium channels (BKCa) in myogenic autoregulatory dysfunction, middle cerebral arteries (MCAs) were isolated from rats with severe weight drop-impact acceleration brain injury (24 h post-impact)...
November 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29169168/anterior-borderzone-angle-for-hemodynamic-collateral-metric-in-patients-with-symptomatic-middle-cerebral-artery-stenosis
#7
Yongkun Li, Yunyun Xiong, Qiankun Cai, Dezhi Liu, Qiliang Dai, Wenhua Liu, Zhixin Huang, Wen Sun, David S Liebeskind, Yinzhou Wang, Xinfeng Liu
BACKGROUND AND AIMS: We aimed to introduce a parameter of anterior borderzone angle (ABZA) to quantitatively evaluate the ACA-MCA leptomeningeal collaterals for middle cerebral artery stenosis (MCAS). METHODS: Two hundred seventy-five patients with 50-100% MCAS and 100 controls were included. The 95% reference range of ABZA was obtained from the controls. ABZAtrans was defined as "ABZA/the 95% upper limit." Relationships between ABZA and MCAS, -ABZAtrans and the TICI grade, the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) collateral grade were analyzed...
November 23, 2017: European Neurology
https://www.readbyqxmd.com/read/29140405/the-apoptotic-crypt-abscess-an-underappreciated-histologic-finding-in-gastrointestinal-pathology
#8
Geoffrey Talmon, Tristan Manasek, Ross Miller, David Muirhead, Audrey Lazenby
Objectives: To differentiate apoptotic crypt abscesses (ACAs) from neutrophilic crypt abscesses (NCAs). Methods: Cases with crypt abscesses were classified as containing ACAs, NCAs, or mixed crypt abscesses (MCAs) by H&E staining. Sections were stained with cleaved caspase 3 and myeloperoxidase and recategorized. Results: Fifty-nine cases were reviewed: inflammatory bowel disease (IBD; n = 33), acute cellular rejection (n = 5), graft vs host disease (GVHD; n = 14), cytomegalovirus (n = 5), and drug reaction (n = 2)...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29130477/transcranial-doppler-and-lower-extremity-function-in-older-adults-einstein-aging-study
#9
Ali Ezzati, Tatjana Rundek, Joe Verghese, Carol A Derby
OBJECTIVES: To determine whether transcranial Doppler ultrasound (TCD) measures of mean blood flow velocity (MBFV) in the major cerebral arteries are associated with measures of lower extremity function in community-dwelling older adults. DESIGN: Cross-sectional study. SETTING: Community sample. PARTICIPANTS: Individuals aged 70 and older (mean 79.5, 54% female) without dementia participating in the Einstein Aging Study (N = 200)...
November 11, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29127342/chemical-analysis-of-morphological-changes-in-lysophosphatidic-acid-treated-ovarian-cancer-cells
#10
Karen A Bailey, Yuliya Klymenko, Peter E Feist, Amanda B Hummon, M Sharon Stack, Zachary D Schultz
Ovarian cancer (OvCa) cells are reported to undergo biochemical changes at the cell surface in response to treatment with lysophosphatidic acid (LPA). Here we use scanning electron microscopy (SEM) and multiplex coherent anti-Stokes Raman scattering (CARS) imaging via supercontinuum excitation to probe morphological changes that result from LPA treatment. SEM images show distinct shedding of microvilli-like features upon treatment with LPA. Analysis of multiplex CARS images can distinguish between molecular components, such as lipids and proteins...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29102661/cerebrovascular-gene-expression-in-spontaneously-hypertensive-rats-after-transient-middle-cerebral-artery-occlusion
#11
Anne-Sofie Grell, Maryam Mostajeran, Simona Denise Frederiksen, Lars Edvinsson, Saema Ansar
Hypertension is a major risk factor for stroke, which is one of the leading global causes of death. In the search for new and effective therapeutic targets in stroke research, we need to understand the influence of hypertension in the vasculature following stroke. We used Affymetrix whole-transcriptome expression profiling as a tool to address gene expression differences between the occluded and non-occluded middle cerebral arteries (MCAs) from spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats after transient middle cerebral artery occlusion (tMCAO), to provide clues about the pathological mechanisms set in play after stroke...
November 2, 2017: Neuroscience
https://www.readbyqxmd.com/read/29062832/mucinous-cystadenoma-a-rare-hepatic-tumor-in-a-child
#12
Danielle A Ferraguti, Molly McGetrick, Ivan Zendejas, David Hernandez-Gonzalo, Regino Gonzalez-Peralta
Mucinous cystadenomas (MCAs) of the liver (also called hepatic biliary cystadenomas) are rare tumors that comprise about 5% of cystic masses of the liver in adults. These slow-growing lesions most commonly occur in middle-aged individuals, with a female sex predominance. Herein, we present a MCA in a 6-year-old male, one of only very few such cases described in the pediatric literature to date. Although MCAs are generally considered benign lesions, malignant transformation rarely occurs. The recurrence rate is high when partial cyst excision is performed...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29058984/impact-of-histological-thrombus-composition-on-preinterventional-thrombus-migration-in-patients-with-acute-occlusions-of-the-middle-cerebral-artery
#13
Christian Maegerlein, Benjamin Friedrich, Maria Berndt, Kristin Elizabeth Lucia, Lucas Schirmer, Holger Poppert, Claus Zimmer, Jaroslav Pelisek, Tobias Boeckh-Behrens, Johannes Kaesmacher
Purpose The occurrence of thrombus migration (TM) in middle cerebral arteries (MCAs) prior to mechanical thrombectomy (MT) in patients suffering from acute ischemic strokes is a crucial aspect as TM is associated with lower rates of complete reperfusion and worse clinical outcomes. In this study, we sought to clarify whether histological thrombus composition influences TM. Methods We included 64 patients with acute MCA occlusions who had undergone MT. In 11 of the cases (17.2%) we identified TM prior to the interventions...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29024880/experience-with-and-amount-of-postpartum-maternity-care-comparing-women-who-rated-the-care-they-received-from-the-maternity-care-assistant-as-good-or-less-than-good-care
#14
C I Baas, T A Wiegers, T P de Cock, J J H M Erwich, E R Spelten, E K Hutton
OBJECTIVE: The postpartum period is an important time in the lives of new mothers, their children and their families. The aim of postpartum care is 'to detect health problems of mother and/or baby at an early stage, to encourage breastfeeding and to give families a good start' (Wiegers, 2006). The Netherlands maternity care system aims to enable every new family to receive postpartum care in their home by a maternity care assistant (MCA). In order to better understand this approach, in this study we focus on women who experienced the postpartum care by the MCA as 'less than good' care...
September 19, 2017: Midwifery
https://www.readbyqxmd.com/read/29020723/chromosomal-microarray-testing-in-42-korean-patients-with-unexplained-developmental-delay-intellectual-disability-autism-spectrum-disorders-and-multiple-congenital-anomalies
#15
Sun Ho Lee, Wung Joo Song
Chromosomal microarray (CMA) is a high-resolution, high-throughput method of identifying submicroscopic genomic copy number variations (CNVs). CMA has been established as the first-line diagnostic test for individuals with developmental delay (DD), intellectual disability (ID), autism spectrum disorders (ASDs), and multiple congenital anomalies (MCAs). CMA analysis was performed in 42 Korean patients who had been diagnosed with unexplained DD, ID, ASDs, and MCAs. Clinically relevant CNVs were discovered in 28 patients...
September 2017: Genomics & Informatics
https://www.readbyqxmd.com/read/28993752/histological-characteristics-of-intracranial-atherosclerosis-in-a-chinese-population-a-postmortem-study
#16
Wen Jie Yang, Mark Fisher, Lu Zheng, Chun Bo Niu, Annlia Paganini-Hill, Hai Lu Zhao, Yun Xu, Ka Sing Wong, Ho Keung Ng, Xiang Yan Chen
BACKGROUND: Anterior and posterior circulation atherosclerosis differ in vascular risk factors and stroke mechanisms. However, few studies have compared the pathological features between these lesions. Using a series of intracranial artery specimens, we characterized the intracranial atherosclerotic lesions and compared pathological features among different arteries of the intracranial vasculature. METHODS: Intracranial large arteries of 32 consecutively recruited autopsy cases of Chinese adults aged 45 years or older were examined pathologically using routine histology and immunostaining, to characterize the pathological features of the atherosclerotic lesions...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28955737/cyp3a11-is-not-essential-for-the-formation-of-murine-bile-acids
#17
Annika Wahlström, Samer Al-Dury, Marcus Ståhlman, Fredrik Bäckhed, Hanns-Ulrich Marschall
Humans and mice differ substantially in their bile acid profiles as mice in addition to cholic acid (CA) predominantly synthesize 6β-hydroxylated muricholic acids (MCAs) whereas humans produces chenodeoxycholic acid (CDCA) and CA as primary bile acids. Identifying the gene performing 6β-hydroxylation would be useful for 'humanizing' the bile acid profile in mice for studies of the interaction between bile acids, gut microbiota, and host metabolism. We investigated the formation of MCAs in primary murine hepatocytes and found that αMCA is synthesized from CDCA and βMCA from UDCA...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28944130/brain-computed-tomography-angiography-as-an-ancillary-test-in-the-confirmation-of-brain-death
#18
Homa Sadeghian, Mohammad Ali Raeisi, Parviz Dolati, Rouzbeh Motiei-Langroudi
Introduction Brain death (BD) is the irreversible termination of the functioning of the brain. The diagnosis should be first made by clinical criteria and confirmed by using paraclinical confirmatory techniques (ancillary tests). While conventional brain angiography remains the standard method of choice, computed tomography angiography (CTA) has emerged as an alternative method. In this study, we tried to evaluate the accuracy of CTA for the diagnosis of BD. Methods In this study, we included nine patients with a clinical diagnosis of BD, confirmed by electroencephalography (EEG)...
July 19, 2017: Curēus
https://www.readbyqxmd.com/read/28942736/telephone-based-minnesota-cognitive-acuity-screen-predicts-time-to-institutionalization-and-homecare
#19
Seth A Margolis, George D Papandonatos, Geoffrey Tremont, Brian R Ott
BACKGROUND: We assessed the ability of a telephone-administered cognitive screening test - Minnesota Cognitive Acuity Screen (MCAS) - to predict time to assisted living/nursing home placement (i.e. institutionalization) and homecare/institutionalization in healthy controls (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). METHODS: Participants (N = 146; HC = 37; MCI = 70; AD = 39) had baseline MCAS testing and were re-contacted over eight years for dates of starting homecare, institutionalization, and death...
September 25, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28939676/the-protective-effect-of-middle-cerebral-artery-calcification-on-symptomatic-middle-cerebral-artery-infarction
#20
Jang-Hyun Baek, Joonsang Yoo, Dongbeom Song, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo
BACKGROUND AND PURPOSE: The presence of intracranial artery calcification is associated with an increased risk for stroke. However, calcified atherosclerotic plaques are also known to be less vulnerable to rupture. Given this discrepancy, we investigated whether the vulnerability of intracranial arterial atherosclerosis differed based on the presence or absence of calcification. METHODS: We considered consecutive patients with acute stroke in the unilateral middle cerebral artery (MCA) territory...
November 2017: Stroke; a Journal of Cerebral Circulation
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