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Ivan R Da Silva, Joao A Gomes, Ari Wachsman, Gabriel Rodriguez de Freitas, Jose Javier Provencio
BACKGROUND: It is not well understood whether age impacts transcranial Doppler (TCD) mean flow velocities (MFVs) in patients with aneurysmal subarachnoid hemorrhage (SAH) with or without delayed cerebral ischemia (DCI). The aim of our study was to analyze the behavior of TCD MFV during the first 7 days after SAH in patients of different ages and correlate them with the occurrence of DCI. METHODS: This study is a databank analysis of patients with SAH admitted between 2010 and 2012 in a single center...
October 21, 2016: European Neurology
E David Bell, Anthony J Donato, Kenneth L Monson
Cerebral blood vessels are vital to maintaining the health of the brain. Traumatic brain injury (TBI) commonly results in autoregulatory dysfunction and associated failure of cerebral vessels to maintain homeostasis in the brain. While post-injury changes to brain biochemistry are known to contribute to this dysfunction, tissue deformation may also directly alter vascular smooth muscle cell (SMC) function. As a first step toward understanding stretch-induced dysfunction, this study investigates the effect of overstretch on the contractile behavior of SMCs in middle cerebral arteries (MCAs)...
September 22, 2016: Journal of the Mechanical Behavior of Biomedical Materials
Lisa Dolovich, Giulia Consiglio, Linda MacKeigan, Lusine Abrahamyan, Petros Pechlivanoglou, Valeria E Rac, Nedzad Pojskic, Elizabeth A Bojarski, Jiandong Su, Murray Krahn, Suzanne M Cadarette
BACKGROUND: MedsCheck Annual (MCA) is an Ontario government-funded medication review service for individuals taking 3 or more prescription medications for chronic conditions. METHODS: This cohort study analyzed linked administrative claims data from April 1, 2007, to March 31, 2013. Trends in MCA claims and recipient characteristics were examined. RESULTS: A total of 1,498,440 Ontarians (55% seniors, 55% female) received an MCA. One-third (36%) had 2 or more MCAs within 6 years...
September 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
Jialing Pan, Tingting Xu, Fengli Xu, Yali Zhang, Zhiguo Liu, Wenbo Chen, Weitao Fu, Yuanrong Dai, Yunjie Zhao, Jianpeng Feng, Guang Liang
Acute lung injury (ALI) is a major cause of acute respiratory failure in critically-ill patients. Resveratrol and curcumin are proven to have potent anti-inflammatory efficacy, but their clinical application is limited by their metabolic instability. Here, a series of resveratrol and the Mono-carbonyl analogs of curcumin (MCAs) hybrids were designed and synthesized by efficient aldol construction strategy, and then screened for anti-inflammatory activities in vitro and in vivo. The results showed that the majority of analogs effectively inhibited the LPS-induced production of IL-6 and TNF-α...
September 10, 2016: European Journal of Medicinal Chemistry
Donghee Kim, Seung-Yul Lee, Kwon-Duk Seo
Introduction. Fluid-attenuated inversion recovery hyperintense vessels (FHVs) can be seen in patients with occlusion or severe stenosis of the cerebral arteries. FHVs are known to reflect stagnant or slow blood flow within the cerebral artery. Case Report. A 75-year-old woman presented with suddenly developed gait disturbance. She had a history of hypertension, heart failure, and dementia. Brain MRI demonstrated FHVs within both middle cerebral arteries (MCAs). However, there was no acute ischemic lesion and severe stenosis or occlusion of the cerebral arteries...
2016: Case Reports in Neurological Medicine
Nusrat Matin, Paulo W Pires, Hannah Garver, William F Jackson, Anne M Dorrance
OBJECTIVE: Chronic hypertension induces detrimental changes in the structure and function of surface cerebral arteries. Very little is known about parenchymal arterioles (PAs), which perfuse distinct neuronal populations in the cortex and may play a role in cerebrovascular disorders. We investigated the effect of deoxycorticosterone acetate (DOCA)-salt induced hypertension on endothelial function and artery structure in PAs and middle cerebral arteries (MCAs). METHODS: Uninephrectomized male Sprague-Dawley rats were implanted with a subcutaneous pellet containing DOCA (150 mg/kg b...
September 2, 2016: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Xiaowen Tang, Qiaoling Yang, Fan Yang, Junting Gong, Han Han, Li Yang, Zhengtao Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Gentiopicroside (GPS), one of iridoid glucoside representitves, is the most potential active component in Gentiana rigescens Franch. ex Hemsl and Gentiana macrophylla Pall. These two herbs have been used to treat jaundice and other hepatic and billiary diseases in traditional Chinese medicine for thousands of years. AIM OF THE STUDY: This study aimed to investigate the protective effects and mechanisms of GPS on α-naphthylisothiocyanate (ANIT) induced cholestatic liver injury in mice...
August 28, 2016: Journal of Ethnopharmacology
Andreas Oldag, Jens Neumann, Michael Goertler, Hermann Hinrichs, Hans-Jochen Heinze, Andreas Kupsch, Catherine M Sweeney-Reed, Klaus Kopitzki
The measurement of autoregulatory delay by near-infrared spectroscopy (NIRS) has been proposed as an alternative technique to assess cerebral autoregulation, which is routinely assessed via transcranial Doppler sonography (TCD) in most centers. Comparitive studies of NIRS and TCD, however, are largely missing. We investigated whether cerebrovascular reserve (CVR), as assessed via TCD, correlates with the delay of the autoregulatory response to changes in arterial blood pressure (ABP) as assessed by NIRS, i...
November 2016: Journal of Neurology
Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, Maria Tunde Magyar, Laszlo Csiba, Laszlo Olah
BACKGROUND: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects. METHODS: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake...
September 15, 2016: Journal of the Neurological Sciences
Nikil Patel, Ronney B Panerai, Victoria Haunton, Emmanuel Katsogridakis, Nazia P Saeed, Angela Salinet, Fiona Brodie, Nazia Syed, Schnell D'Sa, Thompson G Robinson
Normative values of physiological parameters hold significance in modern day clinical decision-making. Lack of such normative values has been a major hurdle in the translation of research into clinical practice. A large database containing uniform recordings was constructed to allow more robust estimates of normative ranges and also assess the influence of age and sex. Doppler recordings were performed on healthy volunteers in the same laboratory, using similar protocols and equipment. Beat-to-beat blood pressure, heart-rate, electrocardiogram, and end-tidal CO2 were measured continuously...
September 2016: Physiological Measurement
M Turk, M Zaletel, J Pretnar Oblak
OBJECTIVE: Leukoaraiosis (ILA) is believed to be ischaemic in origin due its association with cerebrovascular risk factors and similar location as lacunar infarctions. Its pathophysiology is not well understood and its diagnosis is still based on magnetic resonance imaging (MRI) as well as exclusion of other causes of white matter hyperintensities (WMH). So far there are no known confirming or screening diagnostic tests of ILA. Ultrasound studies have recently shown increased large artery stiffness, increased cerebrovascular resistance and lower cerebral blood flow in ILA patients...
September 2016: Journal of Hypertension
Adele Khavari, Magnus Nydén, David A Weitz, Allen J Ehrlicher
The mechanics of the cellular microenvironment can be as critical as biochemistry in directing cell behavior. Many commonly utilized materials derived from extra-cellular-matrix create excellent scaffolds for cell growth, however, evaluating the relative mechanical and biochemical effects independently in 3D environments has been difficult in frequently used biopolymer matrices. Here we present 3D sodium alginate hydrogel microenvironments over a physiological range of stiffness (E = 1.85 to 5.29 kPa), with and without RGD binding sites or collagen fibers...
2016: Scientific Reports
Faruk Tas
BACKGROUND: The most-cited articles. (MCAs) are likely those that impressed other researchers and had profound influence on clinical practice or future developments in the related scientific field. AIM: This study was conducted to explore a bibliometric approach to assess in where the cutaneous malignant melanoma. (CMM) related MCAs have been published. MATERIALS AND METHODS: We identified journals for publications with the word "melanoma" in the title by using the ISI Web of Knowledge Database between 2000 and 2010...
April 2016: Journal of Cancer Research and Therapeutics
Stefan Hm Gorissen, Astrid Mh Horstman, Rinske Franssen, Julie Jr Crombag, Henning Langer, Jörgen Bierau, Frederique Respondek, Luc Jc van Loon
BACKGROUND: Muscle mass maintenance is largely regulated by basal muscle protein synthesis and the capacity to stimulate muscle protein synthesis after food intake. The postprandial muscle protein synthetic response is modulated by the amount, source, and type of protein consumed. It has been suggested that plant-based proteins are less potent in stimulating postprandial muscle protein synthesis than animal-derived proteins. However, few data support this contention. OBJECTIVE: We aimed to assess postprandial plasma amino acid concentrations and muscle protein synthesis rates after the ingestion of a substantial 35-g bolus of wheat protein hydrolysate compared with casein and whey protein...
September 2016: Journal of Nutrition
Marina Dobrivojević, Katarina Špiranec, Dunja Gorup, Igor Erjavec, Nikola Habek, Marin Radmilović, Sanela Unfirer, Anita Ćosić, Ines Drenjančević, Srećko Gajović, Aleksandra Sinđić
Occlusion of cerebral arteries leads to ischemic stroke accompanied by subsequent brain edema. Bradykinin (BK) is involved in the formation of cerebral edema, and natriuretic peptides (NPs) potentially have beneficial effects on brain edema formation via a still unknown mechanism. The aim of this study was clarifying the mechanisms of action of NPs on BK signaling, and their interactive effects after ischemic brain injury. We used a mouse model for stroke, the middle cerebral artery (MCA) occlusion. Brain lesion and edema were measured by microcomputerized tomography volumetric measurements...
July 15, 2016: Experimental Neurology
Yi-Ying Wu, Chia-Lin Chang, Yuan-Jhe Chuang, Jia-En Wu, Chia-Hao Tung, Yeong-Chang Chen, Yuh-Ling Chen, Tse-Ming Hong, Keng-Fu Hsu
Epithelial ovarian cancer (EOC) carries the highest mortality rate of all gynecologic malignancies. This high mortality rate is attributed to the fact that most cases of ovarian cancer are detected at late stages when metastases are already present. Through microarray analysis, we previously demonstrated that castor zinc finger 1 (CASZ1) is up-regulated in EOC cells. In contrast to its role in EOC, CASZ1 functions a tumor suppressor in neuroblastoma. Human CASZ1 is predominantly expressed in 2 alternatively spliced isoforms: CASZ1a and CASZ1b...
2016: American Journal of Cancer Research
Keon-Joo Lee, Keun-Hwa Jung, Chan-Young Park, Jeong-Min Kim, Soon-Tae Lee, Kon Chu, Manho Kim, Sang Kun Lee, Jae-Kyu Roh
OBJECTIVE: We investigated the association of clinical, laboratory, sonographic and imaging parameters, in the progression of single subcortical infarctions. METHODS: Consecutive 169 patients with lacunar (n = 89) and striatocapsular infarctions (n = 80) in the middle cerebral artery (MCA) territory with nonstenotic MCAs were recruited and examined for stroke progression. The pulsatility index (PI) was measured by transcranial Doppler from ipsilateral M1...
July 8, 2016: European Radiology
Mi Ji Lee, Min Kyung Chu, Hanna Choi, Hyun Ah Choi, Chungbin Lee, Chin-Sang Chung
OBJECTIVE: To assess longitudinal changes in cerebral blood flow velocities (ΔCBFVs) according to the clinical course of migraine. METHODS: We retrospectively included migraine patients with two or more attacks per month at baseline who were followed up within 2 years with transcranial Doppler in a tertiary headache clinic. ΔCBFVs were analyzed in relation to clinical courses, defined as remission (0-1 headache days/month), persistence (2-14/month), or progression (≥15/month) in episodic migraine (EM), and conversion to EM (<15/month) and persistence (≥15/month) in chronic migraine (CM)...
July 4, 2016: Cephalalgia: An International Journal of Headache
Guannan Wang, Wei Gao, Xuanjun Zhang, Xifan Mei
Diagnostic approaches based on multimodal imaging of clinical noninvasive imaging (eg. MRI/CT scanner) are highly developed in recent years for accurate selection of the therapeutic regimens in critical diseases. Therefore, it is highly demanded in the development of appropriate all-in-one multimodal contrast agents (MCAs) for the MRI/CT multimodal imaging. Here a novel ideal MCAs (F-AuNC@Fe3O4) were engineered by assemble Au nanocages (Au NC) and ultra-small iron oxide nanoparticles (Fe3O4) for simultaneous T1-T2dual MRI and CT contrast imaging...
2016: Scientific Reports
Mehmet Akif Topcuoglu, Suk-Tak Chan, Gisele Sampaio Silva, Eric Edward Smith, Kenneth K Kwong, Aneesh Bhim Singhal
BACKGROUND: Altered cerebrovascular tone is implicated in reversible cerebral vasoconstriction syndrome (RCVS). We evaluated vasomotor reactivity using bedside transcranial Doppler in RCVS patients. METHODS: In this retrospective case-control study, middle cerebral artery (MCA) blood flow velocities were compared at rest and in response to breath-hold in RCVS (n = 8), Migraineurs (n = 10), and non-headache Controls (n = 10). Hyperventilation response was measured in RCVS...
May 20, 2016: Cephalalgia: An International Journal of Headache
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