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https://www.readbyqxmd.com/read/28292237/gadolinium-iii-based-polymeric-magnetic-resonance-imaging-agents-for-tumor-imaging
#1
Guangyue Zu, Ye Kuang, Jingjin Dong, Tingting Zhang, Yi Cao, Min Liu, Liqiang Luo, Renjun Pei
Contrast agents (CAs) are widely used to improve the signal-noise ratio in the magnetic resonance imaging (MRI) examinations. The majority of MRI CAs used in clinic are gadolinium(III) (Gd(III)) chelates with low molecular weight. Compared with these small-molecule CAs, Gd(III)-based polymeric magnetic resonance imaging agents (i.e. macromolecular contrast agents, mCAs), prepared by conjugating small-molecule Gd(III) chelates onto macromolecules, possess high relaxivity and relative long blood circulation time, which are favorable for MRI examinations...
March 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28280363/discrimination-of-serous-cystadenoma-from-mucinous-cystadenoma-in-the-pancreas-with-contrast-enhanced-ultrasonography-a-prospective-study-in-61-patients
#2
Ya Sun, Fubo Zhou, Fangyi Liu, Yanyan Hu, Shuilian Tan, Ping Liang, Enqiang Linghu, Xiaoling Yu
OBJECTIVES: The preoperative diagnosis between serous cystadenomas (SCAs) and mucinous cystadenomas (MCAs) in pancreas is significant due to their completely different biological behaviors. The purpose of our study was to examine and compare detailed contrast-enhanced ultrasonography (CEUS) images of SCAs and MCAs and to determine whether there are significant findings that can contribute to the discrimination between these two diseases. METHODS: From April 2015 to June 2016, 61 patients (35 patients with SCAs and 26 patients with MCAs) were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28262205/characterization-of-mast-cell-activation-syndrome
#3
Lawrence B Afrin, Sally Self, Jeremiah Menk, John Lazarchick
BACKGROUND: Mast cell activation syndrome (MCAS), a recently recognized nonneoplastic mast cell disease driving chronic multisystem inflammation and allergy, appears prevalent and thus important. We report the first systematic characterization of a large MCAS population. METHOD: Demographics, comorbidities, symptoms, family histories, physical examination and laboratory findings were reviewed in 298 retrospective and 115 prospective patients with MCAS. Blood samples from prospective subjects were examined by flow cytometry for clonal mast cell disease and tested for cytokines potentially driving the monocytosis frequent in MCAS...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28262030/highly-sensitive-assays-are-mandatory-for-the-differential-diagnosis-of-patients-presenting-with-symptoms-of-mast-cell-activation-diagnostic-work-up-of-38-patients
#4
Bea Van den Poel, Anne-Marie Kochuyt, Elke Del Biondo, Barbara Dewaele, Els Lierman, Thomas Tousseyn, Gert de Hertogh, Peter Vandenberghe, Nancy Boeckx
Mastocytosis is a heterogeneous disease caused by excessive mast cell (MC) proliferation. Diagnosis of systemic mastocytosis (SM) is based on the presence of major and minor criteria defined by the World Health Organization. Symptoms of MC activation can also occur in patients without SM or without allergic or inflammatory disease. These MC activation syndromes (MCAS) can be divided into primary (monoclonal) MCAS (MMAS) vs. secondary and idiopathic MCAS. In this single center study, the diagnostic work-up of 38 patients with a clinical suspicion of SM and/or with elevated basic tryptase levels is presented...
March 6, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28249552/hypertension-induced-enhanced-myogenic-constriction-of-cerebral-arteries-is-preserved-after-traumatic-brain-injury
#5
Nikolett Szarka, Krisztina Amrein, Peter Horvath, Ivan Ivic, Endre Czeiter, Andras Buki, Akos Koller, Peter Toth
Traumatic brain injury (TBI) was shown to impair pressure-induced myogenic response of cerebral arteries, which is associated with vascular and neural dysfunction and increased mortality of TBI patients. Hypertension was shown to enhance myogenic tone of cerebral arteries via increased vascular production of 20-hydroxyeicosatrienoic acid (HETE). This adaptive mechanism protects brain tissue form pressure/volume overload, but it can also lead to increased susceptibility to cerebral ischemia. Although both effects may potentiate the detrimental vascular consequences of TBI, it is not known how hypertension modulates the effect of TBI on myogenic responses of cerebral vessels...
March 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28239641/macrovascular-and-microvascular-cerebral-blood-flow-in-adults-at-risk-for-alzheimer-s-disease
#6
Lindsay R Clark, Sara E Berman, Leonardo A Rivera-Rivera, Siobhan M Hoscheidt, Burcu F Darst, Corinne D Engelman, Howard A Rowley, Cynthia M Carlsson, Sanjay Asthana, Patrick Turski, Oliver Wieben, Sterling C Johnson
INTRODUCTION: Capillary hypoperfusion is reported in asymptomatic adults at-risk for Alzheimer's disease (AD), but the extent that can be explained by reduced flow in intracranial arteries is unknown. METHODS: One hundred fifty-five asymptomatic adults enriched for AD risk (mean age 61 years) completed arterial spin labeling (pcASL) and 4D-flow MRI sequences. Voxel-wise regression models investigated the relationship between mean flow in bilateral cerebral arteries and capillary perfusion, and tested potential moderators of this relationship...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28229321/cerebral-endothelial-dysfunction-in-reversible-cerebral-vasoconstriction-syndrome-a-case-control-study
#7
Hyun Ah Choi, Mi Ji Lee, Chin-Sang Chung
BACKGROUND: The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS). METHODS: We prospectively recruited patients with RCVS, age-matched controls with episodic migraine, and age-matched healthy controls at Samsung Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial Doppler evaluation, with a breath-holding maneuver, for the evaluation of bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), and the basilar artery (BA)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28216128/mucinous-cystadenoma-in-children-and-adolescents
#8
Renee A Cowan, Erin N Haber, Fabio R Faucz, Constantine A Stratakis, Veronica Gomez-Lobo
STUDY OBJECTIVE: Mucinous cystadenomas (MCAs) are benign epithelial ovarian tumors that occur rarely in children and adolescents. As children and adolescents typically have their childbearing years ahead of them, conservative therapy is indicated. However, there is concern that ovarian cystectomy may be associated with significant recurrence risk in MCA. Furthermore, GNAS gene mutations are associated with McCune-Albright Syndrome, which is associated with cystic ovaries. We sought to evaluate the outcomes of children and adolescents with MCA treated conservatively...
February 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28058990/restoration-of-the-response-of-the-middle-cerebral-artery-of-the-rat-to-acidosis-in-hyposmotic-hyponatremia-by-the-opener-of-large-conductance-calcium-sensitive-potassium-channels-bkca
#9
Marta Aleksandrowicz, Beata Dworakowska, Krzysztof Dolowy, Ewa Kozniewska
Hyposmotic hyponatremia (the decrease of extracellular concentration of sodium ions from 145 to 121 mM and the decrease of hyposmolality from 300 to 250 mOsm/kg H2O) impairs response of the middle cerebral artery (MCA) to acetylcholine and NO donor (S-nitroso-N-acetyl-DL-penicillamine). Since acidosis activates a similar intracellular signaling pathway, the present study was designed to verify the hypothesis that the response of the MCA to acidosis is impaired during acute hyposmotic hyponatremia due to abnormal NO-related signal transduction in vascular smooth muscle cells...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28057635/in-vivo-assessment-of-the-impact-of-regional-intracranial-atherosclerotic-lesions-on-brain-arterial-3d-hemodynamics
#10
C Wu, S Schnell, P Vakil, A R Honarmand, S A Ansari, J Carr, M Markl, S Prabhakaran
BACKGROUND AND PURPOSE: Intracranial atherosclerosis induces hemodynamic disturbance, which is not well-characterized, particularly in cerebral flow redistribution. We aimed to characterize the impact of regional stenotic lesions on intracranial hemodynamics by using 4D flow MR imaging. MATERIALS AND METHODS: 4D flow MR imaging was performed in 22 symptomatic patients (mean age, 68.4 ± 14.2 years) with intracranial stenosis (ICA, n = 7; MCA, n = 9; basilar artery, n = 6) and 10 age-appropriate healthy volunteers (mean age, 60...
January 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28032649/kras-mutation-coupled-with-p53-loss-is-sufficient-to-induce-ovarian-carcinosarcomas-in-mice
#11
Feng-Hsiang Tang, Tsung-Hua Hsieh, Chia-Yi Hsu, Hsiao-Yun Lin, Cheng-Yu Long, Kuang-Hung Cheng, Eing-Mei Tsai
Ovarian carcinosarcoma cancer is the most lethal form of gynecological malignancy, but the pathogenesis and biological function for this ovarian cancer remain unknown. We establishment the transgenic mouse model of K-ras(G12D) p53(loxP/loxP) and found that K-ras mutation and p53 deletion within the ovarian surface epithelium gave rise to ovarian lesions with a hyperproliferation and endometrioid glandular morphology. Furthermore, double mutant ovaries formed ovarian carcinosarcomas that were high grade and poorly differentiated...
December 29, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28009450/multicompartment-compliance-aids-in-the-community-the-prevalence-of-potentially-inappropriate-medications
#12
David Counter, Derek Stewart, Joan MacLeod, James S McLay
AIMS: To assess the prevalence of potentially inappropriate medications (PIMs) use in a population of community-based multicompartment compliance aid (MCA) users in north-east Scotland. METHODS: Data for MCAs dispensed by 48 of the 50 community pharmacies in Aberdeen City between 1(st) June to 31(st) October 2014, together with concurrently prescribed medications, patient demographics and Carstairs index of social deprivation were recorded. Drug-specific quality indicators for PIMs from the Swedish National Board of Health and Welfare were applied and bivariate logistic regression analysis used to assess for associations with demographic variables...
December 23, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27956465/hfq-and-three-hfq-dependent-small-regulatory-rnas-mgrr-ryhb-and-mcas-coregulate-the-locus-of-enterocyte-effacement-in-enteropathogenic-escherichia-coli
#13
Shantanu Bhatt, Marisa Egan, Jasmine Ramirez, Christian Xander, Valerie Jenkins, Sarah Muche, Jihad El-Fenej, Jamie Palmer, Elisabeth Mason, Elizabeth Storm, Thomas Buerkert
Enteropathogenic Escherichia coli (EPEC) is a significant cause of infantile diarrhea and death in developing countries. The pathogenicity island locus of enterocyte effacement (LEE) is essential for EPEC to cause diarrhea. Besides EPEC, the LEE is also present in other gastrointestinal pathogens, most notably enterohemorrhagic E. coli (EHEC). Whereas transcriptional control of the LEE has been meticulously examined, posttranscriptional regulation, including the role of Hfq-dependent small RNAs, remains undercharacterized...
February 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/27927653/knockdown-of-add3-impairs-the-myogenic-response-of-renal-afferent-arterioles-and-middle-cerebral-arteries
#14
Fan Fan, Mallikarjuna R Pabbidi, Ying Ge, Longyang Li, Shaoxun Wang, Paige N Mims, Richard J Roman
We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA), and autoregulation of renal and cerebral blood flow are impaired in Fawn Hood Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing gamma-adducin (Add3) from Brown Norway rats rescues the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-art and MCA cultured for 36-hours using a 27-mer Dicer-substrate short interfering RNA (DsiRNA)...
December 7, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27830888/morphometric-evaluation-of-the-delayed-cerebral-arteries-response-to-acetazolamide-test-in-patients-with-chronic-carotid-artery-stenosis-using-computed-tomography-angiography
#15
Arkadiusz Szarmach, Paweł J Winklewski, Grzegorz Halena, Mariusz Kaszubowski, Jarosław Dzierżanowski, Maciej Piskunowicz, Edyta Szurowska, Andrzej F Frydrychowski
BACKGROUND: The evidence accumulates that the response to acetazolamide test is delayed on the ipsilateral side to stenosis. However, the effect of acetazolamide beyond 30 minutes after acetazolamide administration remains unknown. The aim of this study was to assess the diameters of: anterior cerebral arteries (ACAs), middle cerebral arteries (MCAs) and posterior cerebral arteries (PCAs) before and 60 minutes after the acetazolamide test. MATERIALS AND METHODS: Seventeen patients with carotid artery stenosis ≥90% on the ipsilateral side and, ≤50% on the contralateral side were enrolled into the study...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27790241/improved-necker-cube-drawing-based-assessment-battery-for-constructional-apraxia-the-mie-constructional-apraxia-scale-mcas
#16
Masayuki Satoh, Chika Mori, Kana Matsuda, Yukito Ueda, Ken-Ichi Tabei, Hirotaka Kida, Hidekazu Tomimoto
BACKGROUND/AIMS: Constructional apraxia (CA) is usually diagnosed by having patients draw figures; however, the reported assessments only evaluate the drawn figure. We designed a new assessment battery for CA (the Mie Constructional Apraxia Scale, MCAS) which includes both the shape and drawing process, and investigated its utility against other assessment methods. METHODS: We designed the MCAS, and evaluated inter- and intrarater reliability. We also investigated the sensitivity, specificity, and positive and negative predictive values in dementia patients, and compared MCAS assessment with other reported batteries in the same subjects...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27789734/elevated-k-channel-activity-opposes-vasoconstrictor-response-to-serotonin-in-cerebral-arteries-of-the-fawn-hooded-hypertensive-rat
#17
Mallikarjuna R Pabbidi, Richard J Roman
Previous studies suggest that middle cerebral arteries (MCAs) of Fawn Hooded Hypertensive (FHH) rats exhibit impaired myogenic response and introgression of a small region of Brown Norway chromosome 1 containing 15 genes restored the response in FHH.1(BN) congenic rat. The impaired myogenic response in FHH rats is associated with an increase in the activity of the large conductance potassium (BK) channel in vascular smooth muscle cells (VSMCs). The present study examined whether the increased BK channel function in FHH rat alters vasoconstrictor response to serotonin (5-HT)...
January 1, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/27764837/effect-of-age-on-transcranial-doppler-velocities-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#18
Ivan R Da Silva, Joao A Gomes, Ari Wachsman, Gabriel Rodriguez de Freitas, Jose Javier Provencio
BACKGROUND: It is not well understood whether age impacts transcranial Doppler (TCD) mean flow velocities (MFVs) in patients with aneurysmal subarachnoid hemorrhage (SAH) with or without delayed cerebral ischemia (DCI). The aim of our study was to analyze the behavior of TCD MFV during the first 7 days after SAH in patients of different ages and correlate them with the occurrence of DCI. METHODS: This study is a databank analysis of patients with SAH admitted between 2010 and 2012 in a single center...
2016: European Neurology
https://www.readbyqxmd.com/read/27736719/cerebrovascular-dysfunction-following-subfailure-axial-stretch
#19
E David Bell, Anthony J Donato, Kenneth L Monson
Cerebral blood vessels are vital to maintaining the health of the brain. Traumatic brain injury (TBI) commonly results in autoregulatory dysfunction and associated failure of cerebral vessels to maintain homeostasis in the brain. While post-injury changes to brain biochemistry are known to contribute to this dysfunction, tissue deformation may also directly alter vascular smooth muscle cell (SMC) function. As a first step toward understanding stretch-induced dysfunction, this study investigates the effect of overstretch on the contractile behavior of SMCs in middle cerebral arteries (MCAs)...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27708675/uptake-of-the-medscheck-annual-medication-review-service-in-ontario-community-pharmacies-between-2007-and-2013
#20
Lisa Dolovich, Giulia Consiglio, Linda MacKeigan, Lusine Abrahamyan, Petros Pechlivanoglou, Valeria E Rac, Nedzad Pojskic, Elizabeth A Bojarski, Jiandong Su, Murray Krahn, Suzanne M Cadarette
BACKGROUND: MedsCheck Annual (MCA) is an Ontario government-funded medication review service for individuals taking 3 or more prescription medications for chronic conditions. METHODS: This cohort study analyzed linked administrative claims data from April 1, 2007, to March 31, 2013. Trends in MCA claims and recipient characteristics were examined. RESULTS: A total of 1,498,440 Ontarians (55% seniors, 55% female) received an MCA. One-third (36%) had 2 or more MCAs within 6 years...
September 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
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