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https://www.readbyqxmd.com/read/27866913/minimally-invasive-plate-osteosynthesis-with-philos-plate-for-proximal-humerus-fractures
#1
Uğur Gönç, Mesut Atabek, Kürşat Teker, Altuğ Tanrıöver
OBJECTIVES: The aim of the present study was to evaluate results, including clinical and radiological outcomes and number of complications, following minimally invasive plate osteosynthesis (MIPO) of proximal humerus fractures, using the PHILOS® proximal humerus internal locking system (Synthes Holding AG, Solothurn, Switzerland). METHODS: Retrospectively evaluated were 31 patients treated with MIPO (12 male, 19 female; average age: 58.4 years). Four patients had 2-part fractures, 14 patients had 3-part fractures, and 13 patients had 4-part fractures, according to Neer classification...
November 18, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27846045/closed-reduction-for-developmental-dysplasia-of-the-hip-early-term-results-from-a-prospective-multicenter-cohort
#2
Wudbhav N Sankar, Alex L Gornitzky, Nicholas M P Clarke, José A Herrera-Soto, Simon P Kelley, Travis Matheney, Kishore Mulpuri, Emily K Schaeffer, Vidyadhar V Upasani, Nicole Williams, Charles T Price
BACKGROUND: Closed reduction (CR) is a common treatment for infantile developmental dysplasia of the hip. The purpose of this observational, prospective, multicenter study was to determine the early outcomes following CR. METHODS: Prospectively collected data from an international multicenter study group was analyzed for patients treated from 2010 to 2014. Baseline demographics, clinical exam, radiographic/ultrasonographic data, and history of previous orthotic treatment were assessed...
November 11, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27829340/preclinical-evaluation-of-avn-322-novel-and-highly-selective-5-ht6-receptor-antagonist-for-the-treatment-of-alzheimer-s-disease
#3
Alexandre V Ivachtchenko, Yan A Ivanenkov, Mark S Veselov
Alla Chem LLC, Hallandale Beach, USA; bAvineuro Pharmaceuticals, Inc., Hallandale Beach, USA; cMoscow Institute of Physics and Technology (State University), Dolgoprudny city, Russian Federation. Abstract: In recent years, 5-hydroxytryptamine subtype 6 receptor (5-HT6 receptor, 5-HT6R) has rapidly emerged as a promising therapeutic target for the treatment of neuropathological disorders, including Alzheimer's disease (AD). Evidence indicates that 5-HT6 receptors are deeply implicated in the processes of learning and memory, while 5-HT6R antagonists were shown to improve cognition in animal models of cognitive impairment...
November 7, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27812914/avascular-necrosis-following-closed-reduction-for-treatment-of-developmental-dysplasia-of-the-hip-a-systematic-review
#4
Catharine S Bradley, Daniel C Perry, John H Wedge, M L Murnaghan, Simon P Kelley
BACKGROUND: Avascular necrosis (AVN) is a significant and potentially devastating complication following the treatment of developmental dysplasia of the hip (DDH). The reported rate of AVN following closed reduction for DDH ranges from 4 to 60%, and the resultant influence on hip development remains unclear. PURPOSE: A systematic review of the literature was undertaken to evaluate the frequency of AVN after more than 5 years of follow-up in children that underwent closed reduction at younger than 2-years of age for DDH...
November 3, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27793326/risk-factors-of-avascular-necrosis-of-the-femoral-head-and-fixation-failure-in-patients-with-valgus-angulated-femoral-neck-fractures-over-the-age-of-50-years
#5
Hyung Keun Song, Ho June Choi, Kyu Hyun Yang
INTRODUCTION: The aim of our study was to identify the risk factors for avascular necrosis of the femoral head (AVN) and fixation failure (FF) after screw osteosynthesis in patients with valgus angulated femoral neck fractures. PATIENTS AND METHODS: We conducted a retrospective study of 308 patients (mean age, 72.5 years, range, 50-97 years), with a mean follow-up of 21.4 months (range, 12-64 months). The risk for failure in treatment (FIT) associated with patient- and fracture-related factors was evaluated by logistic regression analyses...
December 2016: Injury
https://www.readbyqxmd.com/read/27767268/temporal-course-of-avascular-femoral-head-necrosis-in-patients-with-pemphigus-vulgaris
#6
Kamran Balighi, Maryam Daneshpazhooh, Nessa Aghazadeh, Vahide Saeidi, Farzam Shahpouri, Pardis Hejazi, Cheyda Chams-Davatchi
BACKGROUND AND OBJECTIVES: Pemphigus vulgaris (PV) is typically treated with systemic corticosteroids and immunosuppressive agents. Avascular necrosis (AVN) of the femoral head is a well-recognized major complication of corticosteroid therapy. The characteristics of this serious complication in PV remain unknown. PATIENTS AND METHODS: Uncontrolled, retrospective study of all PV-related AVN cases diagnosed at an Iranian autoimmune bullous disease clinic between 1985 and 2013...
October 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27637546/-scaphoid-pseudarthrosis-indications-for-avascular-iliac-crest-or-radius-bone-grafts
#7
A Asmus, M Lautenbach, B Schacher, S Kim, A Eisenschenk
BACKGROUND: Operative treatment of the scaphoid nonunion includes avascular corticocancellous and cancellous bone grafts and increasingly the use of vascular pedicled and free vascular corticocancellous grafts. Especially the latter require a fair amount of operative expertise and experience in microsurgical techniques. OBJECTIVE: Which criteria lead to the decision for or against an avascular graft used for reconstruction of scaphoid nonunion? Is our current classification system of a scaphoid pseudarthrosis able to illustrate our diagnostic potential in a way that makes us refer to operative procedures? METHODS: Evaluation of current literature and expert opinions RESULTS: Avascular bone grafts show a high union rate as long as a sufficient vascularisation of the remaining fragments is present...
September 16, 2016: Der Orthopäde
https://www.readbyqxmd.com/read/27629912/is-the-timing-of-surgery-associated-with-avascular-necrosis-after-unstable-slipped-capital-femoral-epiphysis-%C3%A2-a-multicenter-study
#8
Yusuke Kohno, Yasuharu Nakashima, Toshio Kitano, Taichi Irie, Atsushi Kita, Tomoyuki Nakamura, Hirosuke Endo, Yosuke Fujii, Takayuki Kuroda, Shigeru Mitani, Hiroshi Kitoh, Masaki Matsushita, Tadashi Hattori, Koji Iwata, Yukihide Iwamoto
BACKGROUND: An unstable slipped capital femoral epiphysis (SCFE) is associated with a high rate of avascular necrosis (AVN). The etiology of AVN seems to be multifactorial, although it is not thoroughly known. The aims of our study were to determine the rate of AVN after an unstable SCFE and to investigate the risk factors for AVN, specifically evaluating the notion of an "unsafe window", during which medical interventions would increase the risk for AVN. METHODS: This retrospective multicenter study included 60 patients with an unstable SCFE diagnosed between 1985 and 2014...
September 11, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27618191/contralateral-humerus-avascular-necrosis-diagnosed-immediately-after-radiotherapy-in-a-patient-with-breast-cancer
#9
P D Analan
Radiotherapy (RT) is an important component of treatment for malignant tumours and avascular necrosis (AVN), which is often associated with high morbidity and disability, frequently accompanies this type of therapy. It generally develops in the same extremity with the treated region and may continue long after the treatment is completed. Early identification of AVN has the potential to reduce morbidity and improve the patient's quality of life. Herein, we present a case of contralateral humerus avascular necrosis diagnosed immediately after the first round of RT in a patient with breast cancer...
February 22, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27603189/subcapital-shortening-osteotomy-for-severe-slipped-capital-femoral-epiphysis-preliminary-results-of-the-french-multicenter-study
#10
Brice Ilharreborde, Vincent Cunin, Saad Abu-Amara
BACKGROUND: There is growing evidence that symptomatic femoroacetabular impingement (FAI) can develop after severe slipped capital femoral epiphysis (SCFE) fixed in situ. Realignment procedures have therefore gained popularity, but complication rates remain controversial. Among them, the subcapital shortening osteotomy without hip dislocation has been progressively adopted in France, but results have never been assessed to date. METHODS: All cases performed in 23 French university hospitals between January 2010 and March 2014 were reviewed to (1) describe the surgical procedure, (2) assess the radiologic and functional outcomes, and (3) report complications and more specifically the avascular necrosis rate (AVN) according to initial stability...
September 3, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27598353/symptomatic-avascular-necrosis-an-understudied-risk-factor-for-acute-care-utilization-by-patients-with-scd
#11
Tiffany Yu, Timothy Campbell, Isabella Ciuffetelli, Carlton Haywood, Christopher Patrick Carroll, Linda Resar, John J Strouse, Sophie Lanzkron
OBJECTIVES: Sickle cell disease (SCD) is associated with high healthcare utilization rates and poor outcomes in a subset of patients, although the underlying factors that predict this phenotype are poorly understood. Prior studies suggest that comorbid avascular necrosis (AVN) contributes to high healthcare utilization. We sought to clarify whether AVN independently predicts acute care utilization in adults with SCD and to identify characteristics of those with AVN that predict higher utilization...
September 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27583161/sartorius-muscle-pedicle-iliac-bone-graft-for-the-treatment-of-avascular-necrosis-of-femur-head
#12
Raju Vaishya, Amit Kumar Agarwal, Nishint Gupta, Vipul Vijay
Avascular necrosis (AVN) of femoral head needs to be addressed early in the course of the disease, to prevent progression to osteoarthritis. A revascularizing procedure which can help preserve the head should be considered in young adults to alleviate the need for total hip arthroplasty. We included 40 cases (53 hips) of AVN of femoral head operated with Sartorius muscle pedicle iliac bone grafting, done by the senior author. Early post-operative rehabilitation was done. The weight bearing was delayed for 6 weeks...
August 2016: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/27529045/the-role-of-dynamic-contrast-enhanced-mri-in-a-child-with-sport-induced-avascular-necrosis-of-the-scaphoid-a-case-report-and-literature-review
#13
Baris Beytullah Koc, Martijn Schotanus, Bob Jong, Pieter Tilman
Avascular necrosis (AVN) of the scaphoid in children is very rare and there is currently no consensus when conservative or operative treatment is indicated. A 10-year-old boy, practicing karate, presented with acute pain in his left wrist after falling on the outstretched hand. Imaging showed a scaphoid waist fracture with signs of an ongoing AVN. The diagnosis of AVN was confirmed with signal loss of the scaphoid on MRI T1. A dynamic contrast-enhanced MRI was performed for further assessment of the proximal pole vascularity and treatment planning...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27512217/osteosynthesis-of-ununited-femoral-neck-fracture-by-internal-fixation-combined-with-iliac-crest-bone-chips-and-muscle-pedicle-bone-grafting
#14
D D Baksi, A K Pal, D P Baksi
BACKGROUND: Ununited femoral neck fracture is seen commonly in developing countries due to delayed presentation or failure of primary internal fixation. Such fractures, commonly present with partial or total absorption of femoral neck, osteonecrosis of femoral head in 8-30% cases with upward migration of trochanter posing problem for osteosynthesis, especially in younger individuals. Several techniques for treatment of such conditions are described like osteotomies or nonvascularied cortical or cancellous bone grafting provided varying degrees of success in terms of fracture union but unsatisfactory long term results occurred due to varying incidence of avascular necrosis (AVN) of femoral head...
July 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27500319/testing-the-efficacy-of-pharmacological-agents-in-a-pericardial-target-delivery-model-in-the-swine
#15
Tinen L Iles, Brian Howard, Stephen Howard, Stephen Quallich, Christopher Rolfes, Eric Richardson, Hanna R Iaizzo, Paul A Iaizzo
To date, many pharmacological agents used to treat or prevent arrhythmias in open-heart cases create undesired systemic side effects. For example, antiarrhythmic drugs administered intravenously can produce drops in systemic pressure in the already compromised cardiac patient. While performing open-heart procedures, surgeons will often either create a small port or form a pericardial cradle to create suitable fields for operation. This access yields opportunities for target pharmacological delivery (antiarrhythmic or ischemic preconditioning agents) directly to the myocardial tissue without undesired side effects...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27461924/transtrochanteric-rotational-osteotomy-for-avascular-necrosis-of-the-femoral-head-after-unstable-slipped-capital-femoral-epiphysis-10-year-clinical-results
#16
Yasuharu Nakashima, Takuaki Yamamoto, Jun-Ichi Fukushi, Goro Motomura, Satoshi Hamai, Yusuke Kohno, Yukihide Iwamoto
BACKGROUND: Avascular necrosis of the femoral head (AVN) is the most serious complication after unstable slipped capital femoral epiphysis (SCFE), and is often unsalvageable. We report a minimum 10 years of clinical results for transtrochanteric rotational osteotomy of the femoral head (TRO) for AVN. METHODS: This study included 7 patients (7 hips) with a mean age at surgery of 13.3 years, and the follow-up period was 15.8 years. All patients had prior treatment via closed reduction and pinning of the unstable SCFE, and showed severely collapsed femoral heads...
July 22, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27442664/association-between-open-or-closed-reduction-and-avascular-necrosis-in-developmental-dysplasia-of-the-hip-a-prisma-compliant-meta-analysis-of-observational-studies
#17
Ya-Jie Wang, Fan Yang, Qi-Jun Wu, Shi-Nong Pan, Lian-Yong Li
BACKGROUND: The risk of avascular necrosis of the femoral head (AVN) after treatment of developmental dysplasia of the hip is associated with the method of reduction. Some authors have suggested that open reduction is a risk factor for AVN; however, this is controversial. To our knowledge, a quantitative comparison of the incidence of AVN between closed and open reduction has not been conducted. METHODS: Published studies were identified by searching PubMed, EMBASE, and the Cochrane Library up to May, 2015, focusing on the incidence of AVN after closed or open reduction for developmental dysplasia of the hip in children aged <3 years...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27421741/effects-of-hypoxia-on-osteogenic-differentiation-of-mesenchymal-stromal-cells-used-as-a-cell-therapy-for-avascular-necrosis-of-the-femoral-head
#18
Gabriela Ciapetti, Donatella Granchi, Caterina Fotia, Lucia Savarino, Dante Dallari, Nicola Del Piccolo, Davide Maria Donati, Nicola Baldini
BACKGROUND AIMS: Avascular necrosis of the femoral head (AVN) occurs as common result of various conditions or develops as a primary entity, with a high freqency in young adults. Because of its tendency toward osteoarthritis requiring total hip arthroplasty, alternative treatments are being advocated, including cell therapy with mesenchymal stromal cells (MSCs). Because osteonecrotic bone is a severely hypoxic tissue, with a 1-3% oxygen tension, the survival and function of multipotent cells is questionable...
September 2016: Cytotherapy
https://www.readbyqxmd.com/read/27347233/transphyseal-femoral-neck-fracture-in-a-twenty-month-old-male-child
#19
Matthew J Brown, Michael R Ferrick
Transphyseal femoral neck fractures are an extremely rare event, mainly occurring in children subjected to an significant traumatic force. The diagnosis is usually suggested by clinical examination with radiographic confirmation. Management varies; however, no consensus exists as to proper treatment. Intervention is primarily focused on the prevention of avascular necrosis (AVN) of the femoral epiphysis. We present the case of a 20-month-old male with a delayed diagnosis of transphyseal femoral neck fracture...
2016: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/27339800/results-of-treatment-of-lymphoblastic-lymphoma-at-the-children-cancer-hospital-egypt-a-single-center-experience
#20
Hany Abdel Rahman Sayed, Mohamed Sedky, Asmaa Hamoda, Naglaa El Kinaaie, Madeha El Wakeel, Dina Hesham
Introduction Lymphoblastic lymphoma (LBL) and acute lymphoblastic leukemia (ALL) are neoplasms of immature B or T-cell precursors. They are considered as a unique biological entity in the 2008 World Health Organization Classification of Hematologic Neoplasm. Both entities are arbitrarily separated by a cut-off point of 20-25% of blast cells in the bone marrow. Treatment of LBL has evolved over time from conventional high-grade NHL schedules to ALL-derived protocols. The aim of this work is to report the clinical characteristics, overall survival (OS), event free survival (EFS), and common chemotherapy toxicities of lymphoblastic lymphoma (LBL) patients during a 5...
September 2016: Journal of the Egyptian National Cancer Institute
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