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AVN treatment

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https://www.readbyqxmd.com/read/28742784/treatment-and-complications-of-patients-with-ipsilateral-acetabular-and-femur-fractures-a-multicenter-retrospective-analysis
#1
Justin M Hire, Preston J Boyer, Heidi Israel, Lisa K Cannada, Hassan Mir, Jason Halvorson, Gregory J Della Rocca, Bryan Ming, Brian Mullis, Chetan Deshpande
OBJECTIVES: The purpose of this study was to review the treatment of ipsilateral acetabular and femur fracture patients to provide descriptive demographic data, injury pattern classification, treatment and evaluate the complication profile reflective of current practices. STUDY DESIGN: Multicenter retrospective cohort. SETTING: Eight Level 1 Trauma Centers. PATIENTS/PARTICIPANTS: 101 patients met inclusion criteria. INTERVENTION: Surgical treatment of both the acetabular and femur fracture...
July 24, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28705216/surgical-management-of-hawkins-type-iii-talar-neck-fracture-through-the-approach-of-medial-malleolar-osteotomy-and-mini-plate-for-fixation
#2
Hui Liu, Zhida Chen, Wenrong Zeng, Yuanfei Xiong, Yongzhi Lin, Huacheng Zhong, Jin Wu
BACKGROUND: Fractures of the talar neck are relatively uncommon yet current interventions suffer from a high incidence of complications and poor functional outcomes. In the present study, we report a surgical treatment of Hawkins type III talar neck fracture through the approach of medial malleolar osteotomy and mini-plate for fixation and discuss the therapeutic effects after long-term follow-up. METHODS: From January 2010 to January 2015, 21 patients with 22 fractures were treated using this approach within days of sustaining the injury...
July 14, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28704297/surgical-treatment-of-displaced-pediatric-lateral-condyle-fractures-of-the-humerus-by-the-posterior-approach
#3
William K Conaway, William L Hennrikus, Samine Ravanbakhsh, Zachary Winthrop, John Mahajan
The surgical approach for open reduction and internal fixation of lateral condyle fractures in children is controversial. Some authors recommend the lateral approach to the elbow over the posterior approach because of theoretical concern for injury to the vascular supply of the distal humerus and potential avascular necrosis (AVN). The purpose of this retrospective case series study is to report the outcomes of open reduction and internal fixation of displaced lateral condyle fractures of the humerus by the posterior approach...
July 12, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28673200/analysis-of-functional-outcome-of-hoffa-fractures-a-retrospective-review-of-32-patients
#4
Vivek Trikha, Saubhik Das, Sahil Gaba, Prabhat Agrawal
PURPOSE: Hoffa fractures are uncommon intra-articular fractures of femoral condyle in coronal plane. The purpose of our study is to assess radiologic and functional outcome in operatively treated Hoffa fractures. METHODS: We retrospectively reviewed 32 patients of isolated Hoffa fracture from January 2010 to March 2015. All were treated with open reduction and internal fixation using lateral approach for lateral Hoffa and medial approach for medial Hoffa fracture...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28638723/low-dose-methotrexate-in-sickle-cell-disease-a-pilot-study-with-rationale-borrowed-from-rheumatoid-arthritis
#5
Silvia R Brandalise, Rosemary Assis, Angelo B A Laranjeira, José Andrés Yunes, Pedro O de Campos-Lima
BACKGROUND: Inflammation is a major feature of sickle cell disease (SCD). Low-dose methotrexate (MTX) has long been used in chronic inflammatory diseases. This pilot study examined the MTX effect on acute vaso-occlusive pain crises (VOC) in SCD patients. METHODS: Fourteen adults on hydroxyurea with severe and refractory VOC received one intramuscular injection of 10 mg of MTX per week for 12 weeks. A single weekly dose of 5 mg of leucovorin was administered orally 48 h after each MTX injection...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28626591/a-case-of-trapezium-avascular-necrosis-treated-conservatively
#6
Evangelos Petsatodis, Konstantinos Ditsios, Panagiotis Konstantinou, Iosafat Pinto, Lazaros Kostretzis, Ioannis Theodoroudis, Mayia Pilavaki
INTRODUCTION: Avascular necrosis (AVN) of the bones of the wrist most commonly involves the lunate followed by the proximal pole of the scaphoid and the capitate. Trapezium avascular necrosis is extremely rare with only two cases reported in the literature, both of which were treated surgically. In this article, we report a unique case of trapezium avascular necrosis treated conservatively. CASE PRESENTATION: A 38-year-old man complaining of a 4-month history of mild pain on the base of his right thumb...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28550249/avn-492-a-novel-highly-selective-5-ht6r-antagonist-preclinical-evaluation
#7
Alexandre V Ivachtchenko, Ilya Okun, Vladimir Aladinskiy, Yan Ivanenkov, Angela Koryakova, Ruben Karapetyan, Oleg Mitkin, Ramiz Salimov, Andrey Ivashchenko
Discovery of 5-HT6 receptor subtype and its exclusive localization within the central nervous system led to extensive investigations of its role in Alzheimer's disease, schizophrenia, and obesity. In the present study, we present preclinical evaluation of a novel highly-potent and highly-selective 5-HT6R antagonist, AVN-492. The affinity of AVN-492 to bind to 5-HT6R (Ki = 91 pM) was more than three orders of magnitude higher than that to bind to the only other target, 5-HT2BR, (Ki = 170 nM). Thus, the compound displayed great 5-HT6R selectivity against all other serotonin receptor subtypes, and is extremely specific against any other receptors such as adrenergic, GABAergic, dopaminergic, histaminergic, etc...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28529656/imaging-modalities-in-patients-with-slipped-capital-femoral-epiphysis
#8
T Hesper, C Zilkens, B Bittersohl, R Krauspe
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a frequent disorder of the adolescent hip, which may lead to avascular necrosis (AVN) of the femoral head, chondrolysis and early osteoarthritis due to the post-slip deformity of the proximal femur. To warrant the best possible outcome for the affected (and contralateral) hip, early diagnosis and proper treatment are needed. METHODS: A review of the literature was undertaken to identify today's role of available imaging modalities in the management of SCFE...
April 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28507969/core-decompression-with-synthetic-grafting-as-a-joint-preservation-strategy-in-humeral-avascular-necrosis-due-to-sickle-cell-anemia-a-case-report
#9
Andrew M Steffensmeier, Karen Kirkham, John M Wiemann
INTRODUCTION: Avascular necrosis (AVN) of the femoral or humeral heads in patients with sickle cell anemia is a common and painful condition. There is currently no gold standard treatment protocol for this condition. Typically, the pain is managed with narcotics and activity restriction until there has been collapse of the subchondral bone with a degree of arthrosis sufficient to warrant total joint arthroplasty. This method entails prolonged pain for the patient and decreases the ability to function occupationally and recreationally...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507661/bone-marrow-aspirate-concentrate-in-combination-with-intravenous-iloprost-increases-bone-healing-in-patients-with-avascular-necrosis-of-the-femoral-head-a-matched-pair-analysis
#10
Hakan Pilge, Bernd Bittersohl, Johannes Schneppendahl, Tobias Hesper, Christoph Zilkens, Martin Ruppert, Rüdiger Krauspe, Marcus Jäger
With disease progression, avascular necrosis (AVN) of the femoral head may lead to a collapse of the articular surface. The exact pathophysiology of AVN remains unclear, although several conditions are known that can result in spontaneous cell death, leading to a reduction of trabecular bone and the development of AVN. Hip AVN treatment is stage-dependent in which two main stages of the disease can be distinguished: pre-collapse (ARCO 0-II) and post-collapse stage (ARCO III-IV, crescent sign). In the pre-collapse phase, core decompression (CD), with or without the addition of bone marrow (e...
November 17, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/28495027/medial-femoral-condyle-microvascular-bone-transfer-as-a-treatment-for-capitate-avascular-necrosis-surgical-technique-and-case-report
#11
Nikolas H Kazmers, Joshua C Rozell, Kevin M Rumball, Scott H Kozin, Dan A Zlotolow, L Scott Levin
Avascular necrosis (AVN) of the capitate is a rare clinical entity for which a variety of treatment options have been described, ranging from immobilization to microvascular bone transfer. Outcomes following medial femoral condyle corticocancellous free flap reconstruction have not been reported for this specific pathology. We present the case of a 16-year-old girl with posttraumatic capitate AVN who was treated with curettage and medial femoral condyle corticocancellous vascularized bone grafting. At 18 months after surgery, the patient remains pain-free and had resumed all activities including lifeguarding by 6 months after surgery...
May 9, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28461967/core-decompression-and-biotechnologies-in-the-treatment-of-avascular-necrosis-of-the-femoral-head
#12
Giorgio Maria Calori, Emilio Mazza, Alessandra Colombo, Simone Mazzola, Massimiliano Colombo
Avascular necrosis (AVN) of the femoral head (FH) causes 5% to 12% of total hip arthroplasties (THA). It especially affects active male adults between the third and fifth decades of life. The exact worldwide incidence is unknown. There are only few data related to each country, but most of it relates to the United States.Non-surgical management has a very limited role in the treatment of AVN of the FH and only in its earliest stages. Core decompression (CD) of the hip is the most common procedure used to treat the early stages of AVN of the FH...
February 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28430719/intertrochanteric-osteotomy-for-femoral-neck-nonunion-does-undercorrection-result-in-an-acceptable-rate-of-femoral-neck-union
#13
Brandon J Yuan, David W Shearer, David P Barei, Sean E Nork
OBJECTIVES: To analyze the radiographic outcomes of intertrochanteric osteotomy for the treatment of femoral neck nonunion with "undercorrection" of the Pauwels angle and relative preservation of the proximal femoral anatomy. DESIGN: Retrospective cohort study. SETTING: Level-1 trauma center. PATIENTS: Thirty-two patients with established femoral neck nonunions that had been treated with intertrochanteric osteotomy were retrospectively identified through Current Procedural Terminology codes...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28416828/-application-of-bilateral-direct-anterior-approach-total-hip-arthroplasty-a-report-of-22-cases
#14
J Tang, M Lv, Y X Zhou, J Zhang
OBJECTIVE: To analyze the operation technique and the methods to avoid early complications on the learning curve for bilateral direct anterior approach (DAA) total hip arthroplasty (THA). METHODS: We retrospectively studied a series of continued cases with bilateral avascular necrosis of the femoral head (AVN) or degenerative dysplastic hip and rheumatoid arthritis that were treated by DAA THA in Beijing Jishuitan Hospital. A total of 22 patients with 44 hips were analyzed from June 2014 to August 2016 in this study...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28371500/joint-preserving-surgery-for-talar-malunions-or-nonuions
#15
Gang Chen, Mu Hu, Yang Xu, Yue-Huan Zhen, Yuan Hong, Xiang-Yang Xu
OBJECTIVE: To describe the technique and analyze the outcomes of joint-preserving surgical treatments which included anatomical reconstruction or alignment correction for talar malunions or nonunions, and avoid development of degenerative changes in the adjacent joints. METHODS: Eight patients who had painful talar malunions or nonunions treated between 2009 and 2015 were included in this retrospective study. The mean age of the patients was 35.6 years, with patients aged from 18 to 58 years...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28328562/treatment-of-unstable-versus-stable-slipped-capital-femoral-epiphysis-using-the-modified-dunn-procedure
#16
Richard L Davis, Walter P Samora, Freddie Persinger, Kevin E Klingele
BACKGROUND: The modified Dunn procedure (open subcapital realignment via a surgical dislocation approach) has been shown to be a safe and effective way of treating acute, unstable slipped capital femoral epiphysis (SCFE). There is a paucity of literature comparing the modified Dunn procedure in stable SCFE. The purpose of this study was to compare acute, unstable versus chronic, stable SCFE managed with the modified Dunn procedure. METHODS: A retrospective chart review was performed on 44 skeletally immature patients who underwent the modified Dunn procedure for SCFE...
March 21, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28283822/antiproliferative-activity-of-vitexin-2-o-xyloside-and-avenanthramides-on-caco-2-and-hepg2-cancer-cells-occurs-through-apoptosis-induction-and-reduction-of-pro-survival-mechanisms
#17
Emanuele Salvatore Scarpa, Elena Antonini, Francesco Palma, Michele Mari, Paolino Ninfali
PURPOSE: CaCo-2 colon cancer cells and HepG2 liver cancer cells represent two malignant cell lines, which show a high resistance to apoptosis induced by the conventional anticancer drugs. Vitexin-2-O-xyloside (XVX) and avenanthramides (AVNs) are naturally occurring dietary agents from Beta vulgaris var. cicla L. and Avena sativa L., respectively. The aim of this work was to evaluate the antiproliferative effects and the reduction of the pro-survival mechanisms exerted by XVX and AVNs, used individually and in combination, in CaCo-2 and HepG2 cancer cells...
March 10, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28247610/-operative-versus-non-operative-treatment-for-three-or-four-part-proximal-humeral-fractures-in-elderly-patients-a-meta-analysis-of-randomized-controlled-trials
#18
Wenbo Li, Gaoheng Ding, Jun Liu, Jie Shi, Chao Zhang, Qiuming Gao
Objective: To evaluate the efficacy of operative and non-operative treatment for three- or four-part proximal humeral fractures in elderly patients by meta-analysis. Methods: The literature search was performed in Cochrance Library, Medline, Embase, SinoMed, CNKI, Wanfang data and CQVIP databases for operative and non-operative treatment of three- or four-part proximal humeral fractures in elderly patients, and searches of conference proceedings were also conducted. The data were extracted and a meta-analysis was performed using RevMan 5...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28241727/-analysis-of-outcomes-of-one-stage-operation-for-treatment-of-late-diagnosed-developmental-dysplasia-of-hip
#19
Y Liu, J Sun
Objective: To evaluate and identify the middle-term results of one-stage open reduction of patients in late-diagnosed developmental dysplasia of the hip, and to explore the best age group for treatment. Methods: A total number of 311 patients (390 hips) with LDDH in Department of Pediatric Orthopaedic of Anhui Provincial Children's Hospital from June 2006 to December 2010 were retrospectively reviewed. The patients were divided into 3 groups according to age at the start of surgical treatment: 1.5-2.5 years, 2...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28188487/management-and-radiographic-outcomes-of-femoral-head-fractures
#20
John A Scolaro, Geoffrey Marecek, Reza Firoozabadi, James C Krieg, Milton Lee Chip Routt
BACKGROUND: Femoral head fractures are uncommon injuries. Small series constitute the majority of the available literature. Surgical approach and fracture management is variable. The purpose of this study was to evaluate the incidence, method of treatment, and outcomes of consecutive femoral head fractures at a regional academic Level I trauma center. MATERIALS AND METHODS: A retrospective review of a prospective database was performed over a 13-year period. All AO/OTA 31C femoral head fractures were identified...
February 10, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
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