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https://www.readbyqxmd.com/read/29451057/comparison-between-modified-dunn-procedure-and-in-situ-fixation-for-severe-stable-slipped-capital-femoral-epiphysis
#1
Giovanni Trisolino, Stefano Stilli, Giovanni Gallone, Pedro Santos Leite, Giovanni Pignatti
Background and purpose - The best treatment option for severe slipped capital femoral epiphysis (SCFE) is still controversial. We compared clinical and radiographic outcomes of modified Dunn procedure (D) and in situ fixation (S) in severe SCFE. Patients and methods - We retrospectively compared D and S, used for severe stable SCFE (posterior sloping angle (PSA) > 50°) in 29 patients (15 D; 14 S). Propensity analysis and inverse probability of treatment weights (IPTW) to adjust for baseline differences were performed...
February 16, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29423066/interferon-%C3%AE-protects-against-avascular-osteonecrosis-through-interleukin-6-inhibition-and-silent-information-regulator-transcript-1-upregulation
#2
Kyoung Min Kim, Sajeev Wagle, Young Jae Moon, Sung Il Wang, Byung-Hyun Park, Kyu Yun Jang, Jung Ryul Kim
Synovitis of the affected joint is a common in avascular osteonecrosis (AVN). Increased levels of pro-inflammatory cytokine interleukin-6 (IL-6) have been reported in AVN, but the mechanism of this increase remains unclear. Silent information regulator transcript-1 (SIRT1), an NAD-dependent deacetylase, inhibits the release of inflammatory cytokines. Interferon β (IFN-β) has clear anti-inflammatory properties. We sought to investigate the effects of IFN-β treatment on AVN and to evaluate the specific signal pathway relating to IL-6 and SIRT1 affected during AVN...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29411077/regenerative-therapies-increase-survivorship-of-avascular-necrosis-of-the%C3%A2-femoral-head-a-systematic-review-and-meta-analysis
#3
REVIEW
Luca Andriolo, Giulia Merli, Carlos Tobar, Sante Alessandro Altamura, Elizaveta Kon, Giuseppe Filardo
PURPOSE: The aim of this study was to document the available evidence on the use of regenerative techniques for the treatment of femoral head osteonecrosis (or avascular necrosis of femoral head, AVN) and to understand their benefit compared to core decompression (CD) alone in avoiding failure and the need for total hip replacement (THR). METHODS: The search was conducted on three medical electronic databases according to PRISMA guidelines. The studies reporting number and timing of failures were included in a meta-analysis calculating cumulative survivorship with a Kaplan-Mayer curve...
February 6, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29389704/versatility-of-the-medial-femoral-condyle-flap-for-extremity-reconstruction-and-identification-of-risk-factors-for-nonunion-delayed-time-to-union-and-complications
#4
Nikolas H Kazmers, Stephanie Thibaudeau, Patrick Gerety, Alex G Lambi, Lawrence Scott Levin
BACKGROUND: The medial femoral condyle (MFC) flap has become a popular choice for treatment of small bony defects. We aim to describe outcomes after MFC flap treatment of upper and lower extremity osseous defects and test the null hypothesis that no factors influence risks for nonunion, increased time to union, and complications. METHODS: A retrospective chart review was performed on all patients undergoing MFC free vascularized bone flaps by the senior author between May 2010 and March 2016...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29382681/evaluating-the-role-of-prereduction-hip-traction-in-the-management-of-infants-and-children-with-developmental-dysplasia-of-the-hip-ddh-protocol-for-a-systematic-review-and-planned-meta-analysis
#5
Sarah Walton, Emily Schaeffer, Kishore Mulpuri, Peter Cundy, Nicole Williams
INTRODUCTION: Developmental dysplasia of the hip (DDH) affects 4-6 per 1000 live births in developed countries. Effective treatment to realign the hip is necessary to avoid long-term morbidities and maximise functional outcome. Treatment options depend on patient age but typically involve hip bracing and/or reduction under general anaesthetic. Some centres also employ prereduction hip traction. Historical papers suggest traction reduces risk of avascular necrosis (AVN) femoral head and reduces requirement for open reduction...
January 29, 2018: BMJ Open
https://www.readbyqxmd.com/read/29379808/outcome-after-surgical-management-of-acetabular-fractures-a-7-year-experience
#6
Seyed Amir Reza Mesbahi, Ali Ghaemmaghami, Sara Ghaemmaghami, Pouya Farhadi
Objective: To determine the functional and radiologic results of surgical treatment in patients with acetabular fractures. Methods: This was a retrospective cross-sectional study. We retrospectively reviewed medical records of patients operatively treated acute acetabular fractures at a level I trauma center (Shahid Rajaee) and an orthopedic center (Shahid Chamran) both in southern Iran (Shiraz) with minimally 1 year follow up over a period of 7 years from April 2009 to March 2016...
January 2018: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/29371164/anti-inflammatory-effect-of-avenanthramides-via-nf-%C3%AE%C2%BAb-pathways-in-c2c12-skeletal-muscle-cells
#7
Chounghun Kang, Woo Shik Shin, Dongwook Yeo, Wonchung Lim, Li Li Ji
Avenanthramides (Avns), the polyphenol compounds found only in oats, have been shown to exhibit anti-inflammatory effects mainly by inhibiting nuclear factor (NF)-κB activation in select cell lines. However, the molecular mechanism by which Avns regulate the NF-κB pathway is still unclear. The purpose of this study was to investigate (1) the molecular mechanism by which three main fractions of Avns (AvnA, AvnB and AvnC) interact with IκB Kinase β (IKKβ); and (2) whether this interaction results in reduced inflammatory responses in skeletal muscle cells...
January 22, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29361376/diagnosis-and-treatment-of-slipped-capital-femoral-epiphysis-recent-trends-to-note
#8
Takuya Otani, Yasuhiko Kawaguchi, Keishi Marumo
Slipped capital femoral epiphysis (SCFE) is not frequently encountered during routine practice and diagnosis and treatment are often delayed. It is important to understand symptoms and imaging features to avoid delayed diagnosis. After the diagnosis is made correct classification of the disease is required. The classification should be based on the physeal stability in order to choose safe and effective treatment. However, surgeons should bear in mind that the assessment is challenging and actual physeal stability is not always consistent with the stability predicted by a clinical classification method...
January 17, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29182116/surgical-treatment-for-developmental-dysplasia-of-the-hip-a-single-surgeon-series-of-47-hips-with-a-7-year-mean-follow-up
#9
J Mcfarlane, J H Kuiper, N Kiely
The treatment of developmental dysplasia of the hip (DDH) in children remains controversial. We describe the clinical and radiological outcomes of  47 hips in 43 children treated with open surgery by one surgeon between 2004 and 2008 for DDH. The mean age at operation was 25 months (5 to 113) with a mean follow up of  89 months  (22 to 169). At the latest follow up 40 of the 45 hips where Severin grades were recordable (89%) were graded as excellent or good, Severin class I or II. Clinically significant AVN (grade II to III  according to the Kalamchi and MacEwen classification) was seen in 6  (13%) of the hips...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29181188/intra-articular-osteochondroma-of-the-posteroinferior-femoral-neck-associated-with-hip-joint-osteochondromatosis-a-case-report
#10
Sung Il Wang, Eun Hae Park, Sun Jung Yoon, Jung Ryul Kim
Osteochondromas are usually extra-articular lesions originating from the metaphysis of long bones. Intra-articular osteochondromas may also occur, causing pain and discomfort and restricting the range of motion. Osteochondromas of the femoral neck are intra-articular lesions that are difficult to access for surgical resection, particularly when located posteriorly. We herein present a rare case of an intra-articular osteochondroma involving the posteroinferior aspect of the femoral neck associated with secondary synovial osteochondromatosis (SOC) of the hip joint in a 25-year-old woman...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29130113/long-term-results-of-closed-reduction-for-developmental-dislocation-of-the-hip-in-children-of-walking-age-under-eighteen-months-old
#11
Soo Min Cha, Hyun Dae Shin, Byung Kon Shin
BACKGROUND: Developmental dysplasia of the hip (DDH) diagnosed in older postnatal children can be effectively treated by closed reduction (CR) alone. However, no prospective or comparative trial to explore the differential effectiveness of CR between non-walking and walking postnatal children has yet been reported. This study investigated the clinical and radiologic outcomes of CR in the age range of interest (12-18 months old) via a prospective trial and compared these results with those of a younger age group who also underwent CR...
November 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29125919/autologous-chondrocyte-implantation-sandwich-technique-compared-with-autologous-bone-grafting-for-deep-osteochondral-lesions-in-the-knee
#12
Tom Minas, Takahiro Ogura, Jeff Headrick, Tim Bryant
BACKGROUND: Treating symptomatic osteochondral defects is challenging, especially in young adults with deep (>8-10 mm) empty defects after osteochondritis dissecans (OCD) or collapsed condyles secondary to avascular necrosis (AVN). For this population, osteoarthritis (OA) is inevitable if articular congruence is not restored. PURPOSE: To describe the autologous chondrocyte implantation (ACI) "sandwich" technique with autologous bone grafting (ABG) and compare it with ABG alone for restoration of the osteochondral unit...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29081846/avascular-necrosis-in-children-with-cerebral-palsy-after-reconstructive-hip-surgery
#13
L Phillips, K Hesketh, E K Schaeffer, J Andrade, J Farr, K Mulpuri
PURPOSE: Progressive hip displacement is one of the most common orthopaedic pathologies in children with cerebral palsy (CP). Reconstructive hip surgery has become the standard treatment of care. Reported avascular necrosis (AVN) rates for hip reconstructive surgery in these patients vary widely in the literature. The purpose of this study is to identify the frequency and associated risk factors of AVN for reconstructive hip procedures. METHODS: A retrospective analysis was performed of 70 cases of reconstructive hip surgery in 47 children with CP, between 2009 and 2013...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29075150/avenanthramide-c-reduces-the-viability-of-mda-mb-231-breast-cancer-cells-through-an-apoptotic-mechanism
#14
Jordan Hastings, Jason Kenealey
BACKGROUND: Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver cancers in vitro. However, these studies do not elucidate a molecular mechanism for individual AVN. In this study we aim to see the effects of AVN on MDA-MB-231 breast cancer cells. METHODS: An MTT assay was used to determine cell viability...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29068514/high-incidence-of-aseptic-hip-necrosis-in-hodgkin-lymphoma-patients-treated-with-escalated-beacopp-receiving-methylprednisolone
#15
Sandra Basic-Kinda, Ivan Karlak, Nadira Durakovic, Zvonimir Ivan Lubina, Ivo Radman, Snježana Dotlic, Zinaida Peric, Ida Hude, Igor Aurer
BACKGROUND: Escalated BEACOPP (eBEACOPP) is an effective but fairly toxic regimen for treatment of Hodgkin lymphoma (HL). Avascular necrosis of femoral head (AVN) was previously reported to be increased in patients treated with eBEACOPP, but so far no systematic analysis of its frequency has been published. AIMS: We aimed to analyze frequency and identify possible risk factors for AVN development in patients treated with eBEACOPP. METHODS: We identified 26 patients treated with eBEACOPP for newly diagnosed high-risk advanced stage HL, 25 patients alive at the time of study...
October 25, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29068288/timing-of-surgical-intervention-for-developmental-dysplasia-of-the-hip-a-randomised-controlled-trial-hip-op
#16
Charlotte L Williams, Susie Weller, Lisa Roberts, Isabel Reading, Andrew Cook, Louisa Little, Wendy Wood, Louise Stanton, Andreas Roposch, Nicholas Mp Clarke
BACKGROUND: Developmental dysplasia of the hip (DDH) is a very common congenital disorder, and late-presenting cases often require surgical treatment. Surgical reduction of the hip may be complicated by avascular necrosis (AVN), which occurs as a result of interruption to the femoral head blood supply during treatment and can result in long-term problems. Some surgeons delay surgical treatment until the ossific nucleus (ON) has developed, whereas others believe that the earlier the reduction is performed, the better the result...
October 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29026869/associations-between-antiretroviral-treatment-and-avascular-bone-necrosis-the-swiss-hiv-cohort-study
#17
Cornelia Bayard, Bruno Ledergerber, Markus Flepp, Thanh Lecompte, Estelle Moulin, Matthias Hoffmann, Rainer Weber, Cornelia Staehelin, Caroline Di Benedetto, Christoph A Fux, Philip E Tarr, Barbara Hasse
BACKGROUND: HIV-infected individuals have an increased risk of avascular bone necrosis (AVN). Antiretroviral therapy (ART) and particularly protease inhibitors (PI) have been implicated as a risk factor. We aimed to study the associations of ART with the occurrence of AVN among Swiss HIV Cohort Study participants (SHCS). METHODS: We used incidence density sampling to perform a case control study within the Swiss HIV Cohort Study (SHCS) comparing prospectively collected AVN cases and controls by conditional logistic regression analysis...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28904634/treatment-of-chronic-stable-slipped-capital-femoral-epiphysis-via-surgical-hip-dislocation-with-combined-osteochondroplasty-and-imhauser-osteotomy
#18
J B Erickson, W P Samora, K E Klingele
PURPOSE: Treatment of slipped capital femoral epiphysis (SCFE), including the modified Dunn procedure, restores anatomy with significant risk for avascular necrosis (AVN), if performed in the setting of moderate to severe, stable SCFE. The Imhauser osteotomy has been shown to be an effective way to correct residual deformity without the risk of AVN. We sought to evaluate the effectiveness and safety of a combined Imhauser osteotomy and osteochondroplasty, performed via a surgical hip dislocation approach for the acute and delayed treatment of stable SCFE...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28893630/engineered-axially-vascularized-osteogenic-grafts-from-human-adipose-derived-cells-to-treat-avascular-necrosis-of-bone-in-a-rat-model
#19
Tarek Ismail, Rik Osinga, Atanas Todorov, Alexander Haumer, Laurent A Tchang, Christian Epple, Nima Allafi, Nadia Menzi, René D Largo, Alexandre Kaempfen, Ivan Martin, Dirk J Schaefer, Arnaud Scherberich
BACKGROUND: Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. The standard of care, vascularized bone grafts, is limited by donor site morbidity and restricted availability. The aim of this study was to generate and test engineered, axially vascularized SVF cells-based bone substitutes in a rat model of AVN. METHODS: SVF cells were isolated from lipoaspirates and cultured onto porous hydroxyapatite scaffolds within a perfusion-based bioreactor system for 5days...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28861192/comparison-of-outcomes-of-total-hip-arthroplasty-between-patients-with-ankylosing-spondylitis-and-avascular-necrosis-of-the-femoral-head
#20
Sun-Ho Lee, Gun-Woo Lee, Young-Jun Seol, Kyung-Soon Park, Taek-Rim Yoon
BACKGROUND: The objective of this study was to compare clinical and radiological outcomes of total hip arthroplasty (THA) between ankylosing spondylitis (AS) of the hip joint and avascular necrosis (AVN) of the femoral head. METHODS: Thirty patients (30 hips) underwent cementless THA for AS between 2003 and 2012. They were compared to 30 patients (30 hips) who underwent the same procedure for AVN of the femoral head. Each group was matched for age and gender, and both groups had similar preoperative demographic characteristics...
September 2017: Clinics in Orthopedic Surgery
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