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Medical University of South Carolina

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https://www.readbyqxmd.com/read/29345179/regulatory-support-improves-subsequent-irb-approval-rates-in-studies-initially-deemed-not-ready-for-review-a-ctsa-institution-s-experience
#1
Susan Sonne, Stephanie Gentilin, Royce R Sampson, Leslie Bell, Toni Mauney, Summer Young, Katherine Bright, Patrick Flume
We evaluated the impact of a regulatory support service (known as the Regulatory Knowledge and Support [RKS] program), part of the Medical University of South Carolina's Clinical and Translational Science Award, on the success of Institutional Review Board (IRB) applications that have previously been deemed by the IRB to be Not Ready for Review (NRR). At the time of this evaluation, 77 studies had been deemed NRR, 53 of which came from trainees and junior faculty. All the applications that received regulatory support either received IRB approval or were deemed to not be research, and therefore did not require IRB review...
January 1, 2018: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/29299369/pretreatment-albumin-may-aid-in-patient-selection-for-intrahepatic-y-90-microsphere-transarterial-radioembolization-tare-for-malignancies-of-the-liver
#2
Kelly P Orwat, Thomas H Beckham, Samuel Lewis Cooper, Michael S Ashenafi, Michael Bret Anderson, Marcelo Guimaraes, Ricardo Yamada, David T Marshall
Background: Hepatic malignancies are common including primary malignancies and metastases. Transarterial radioembolization (TARE) is an important treatment option. We reviewed safety and efficacy of (TARE) in our patients to identify factors that may impact treatment outcomes in a heterogeneous population. Methods: All patients that received TARE at the Medical University of South Carolina from March 2006 through May of 2014 were included. Kaplan-Meier estimates on overall survival (OS) from date of first procedure are reported...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29284343/evaluation-of-a-medication-intensity-screening-tool-used-in-malignant-hematology-and-bone-marrow-transplant-services-to-identify-patients-at-risk-for-medication-related-problems
#3
Mariana Lucena, Carolyn Bondarenka, Genevieve Luehrs Hayes, Andy Perez
Background In 2014, a screening tool was implemented at Medical University of South Carolina (MUSC) Health to identify patients who are at risk for medication-related events. Patients are classified as high-risk if they meet one of the following criteria: receiving anticoagulation therapy, taking more than 10 scheduled medications upon admission, or readmission within the past 30 days. The goal of this study was to determine risk criteria specific to the malignant hematology (MH) and bone marrow transplant (BMT) patients...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29250904/assessing-a-composite-end-point-for-new-tocolytics-in-clinical-trials-data-from-4-us-integrated-delivery-networks
#4
Jeanne M Pimenta, Emma Brinkley, Timothy H Montague, Kathleen J Beach, Christina Mack
PURPOSE: A composite end point (CE) measuring neonatal benefit was created for use in tocolytic randomized controlled trials with rates assessed using data from one referral hospital. The goal of this study was to assess wider generalizability of the CE, using data from multiple integrated delivery networks, creating a cohort of linked mother-neonate pairs to understand neonatal outcomes in a broad population. METHODS: Retrospective data on births (2001-2012) were collected from 4 US integrated delivery networks in the COMparative effectiveness PAtient Safety and Surveillance (COMPASS) Research Network, and linked mother-neonate pairs were identified...
December 18, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29248818/barriers-facilitators-and-potential-strategies-for-increasing-hpv-vaccination-a-statewide-assessment-to-inform-action
#5
Kathleen B Cartmell, Jennifer Young-Pierce, Shannon McGue, Anthony J Alberg, John S Luque, Maria Zubizarreta, Heather M Brandt
OBJECTIVE: The objective was to investigate how state level strategies in South Carolina could maximize HPV vaccine uptake. DESIGN: An environmental scan identified barriers, facilitators, and strategies for improving HPV vaccination in South Carolina. Interviews were conducted with state leaders from relevant organizations such as public health agencies, medical associations, K-12 schools, universities, insurers, and cancer advocacy organizations. A thematic content analysis design was used...
December 7, 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28845476/opioid-prescription-drug-use-and-expenditures-in-us-outpatient-physician-offices-evidence-from-two-nationally-representative-surveys
#6
Zaina P Qureshi, M Rifat Haider, Rosa Rodriguez-Monguio, Nikki R Wooten, Ruslan V Nikitin, Sarah Ball, Kelly Barth, Ronit Elk, Ronnie Horner, Charles Bennett
BACKGROUND: Opioids are widely prescribed for their analgesic properties. Chronic opioid use is a persistent problem in the US. Nevertheless, little is known about its prescribing and utilization patterns and overall expenditures. OBJECTIVE: This study examined secular trends in opioid prescription drug utilization and expenditures, along with factors associated with opioid prescription drug use in US physician offices. METHODS: National Ambulatory Medical Care Survey (NAMCS) and Medical Expenditure Panel Survey (MEPS) data (2006-2010), both nationally representative surveys, were used to assess the trend, predictors of opioid prescription among US adults (more than 18 years) and the opioid-associated expenditures as a whole and borne by the patients in outpatient settings...
2017: Cancer Therapy & Oncology International Journal
https://www.readbyqxmd.com/read/28765458/looking-back-to-move-ahead-interprofessional-education-in-dental-education
#7
Lindsey M Hamil
Interprofessional education (IPE) is a widely recognized and critical component of dental and health professions education and is included in two of the predoctoral education standards required by the Commission on Dental Accreditation (CODA). Following a review of the literature on the state of IPE education in U.S. dental education programs, this article revisits six institutions identified in previous research as exemplars successfully implementing IPE on their campuses. Interviews were conducted with leaders at the following programs: Columbia University, Medical University of South Carolina, University of Colorado Anschutz Medical Campus, University of Florida, University of Minnesota, and Western University of Health Sciences...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28759323/designing-home-based-telemedicine-systems-for-the-geriatric-population-an-empirical-study
#8
Shraddhaa Narasimha, Sruthy Agnisarman, Kapil Chalil Madathil, Anand Gramopadhye, James T McElligott
Background and Introduction: Telemedicine, the process of providing healthcare remotely using communication devices, has the potential to be useful for the geriatric population when specifically designed for this age group. This study explored the design of four video telemedicine systems currently available and outlined issues with these systems that impact usability among the geriatric population. Based on the results, design suggestions were developed to improve telemedicine systems for this population. MATERIALS AND METHODS: Using a between-subjects experimental design, the study considered four telemedicine systems used in Medical University of South Carolina...
July 31, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28738090/maternal-25-oh-d-concentrations-%C3%A2-40-ng-ml-associated-with-60-lower-preterm-birth-risk-among-general-obstetrical-patients-at-an-urban-medical-center
#9
Sharon L McDonnell, Keith A Baggerly, Carole A Baggerly, Jennifer L Aliano, Christine B French, Leo L Baggerly, Myla D Ebeling, Charles S Rittenberg, Christopher G Goodier, Julio F Mateus Niño, Rebecca J Wineland, Roger B Newman, Bruce W Hollis, Carol L Wagner
BACKGROUND: Given the high rate of preterm birth (PTB) nationwide and data from RCTs demonstrating risk reduction with vitamin D supplementation, the Medical University of South Carolina (MUSC) implemented a new standard of care for pregnant women to receive vitamin D testing and supplementation. OBJECTIVES: To determine if the reported inverse relationship between maternal 25(OH)D and PTB risk could be replicated at MUSC, an urban medical center treating a large, diverse population...
2017: PloS One
https://www.readbyqxmd.com/read/28564548/feasibility-of-developing-a-pediatric-telehealth-network-in-honduras-with-international-consultation-support
#10
Mary Brooks, Kenton R Holden, Reyna M Durón, James T McElligott, Andrea Summer
INTRODUCTION: Honduras is the second poorest country in Central America, and roughly 50% of the population lives in rural areas. A telehealth network linking these areas to larger health centers may improve patient access to care, and physician access to educational opportunities. This pilot study assessed the feasibility of establishing a pediatric telehealth network between underserved clinics in Honduras and the Medical University of South Carolina (MUSC). METHODS: Two underserved Honduran clinics were identified and invited to participate in the telehealth network...
April 2017: Rural and Remote Health
https://www.readbyqxmd.com/read/28538055/high-reliability-principles-must-be-tied-to-value-based-outcomes
#11
Mitchell L Wasden
WellStar Health System and the Medical University of South Carolina (MUSC), highlighted in this issue's feature articles, are two organizations seeking to drive high reliability by educating leaders and incorporating high-reliability principles into their quality improvement (QI) efforts. The organizations have taken slightly different approaches to executing on high reliability, yet both are encouraged by the apparent success of high-reliability principles in other industries.The high-reliability framework is often applied to healthcare despite the limitations of comparing healthcare organizations to nuclear reactors, commercial airlines, and aircraft carriers...
July 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28538053/achieving-high-reliability-through-cultural-mindfulness
#12
Patrick J Cawley, Danielle B Scheurer
Healthcare has enthusiastically embraced quality and safety improvement. Yet, more radical transformation is clearly needed to make a more significant impact on error reduction and to ensure consistent quality. This need for transformation is leading healthcare to examine how other industries, such as nuclear power and aviation, improve safety to achieve a high degree of reliability and avoid potential catastrophes. Research has shown that successful organizations in high-risk industries achieve high reliability by maintaining a cultural mindfulness that allows them to continually reinvent themselves in complex environments...
July 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28471925/improving-staffing-and-nurse-engagement-in-a-neuroscience-intermediate-unit
#13
Charles Nadolski, Pheraby Britt, Leah C Ramos
The neuroscience intermediate unit is a 23-bed unit that was initially staffed with a nurse-to-patient ratio of 1:4 to 1:5. In time, the unit's capacity to care for the exceeding number of progressively acute patients fell short of the desired goals in the staff affecting the nurse satisfaction. The clinical nurses desired a lower nurse-patient ratio. The purpose of this project was to justify a staffing increase through a return on investment and increased quality metrics. METHODS: This initiative used mixed methodology to determine the ideal staffing for a neuroscience intermediate unit...
June 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28460127/effects-of-combining-a-brief-cognitive-intervention-with-transcranial-direct-current-stimulation-on-pain-tolerance-a-randomized-controlled-pilot-study
#14
Abigail Powers, Alok Madan, Megan Hilbert, Scott T Reeves, Mark George, Michael R Nash, Jeffrey J Borckardt
Objective.:  Cognitive behavioral therapy has been shown to be effective for treating chronic pain, and a growing literature shows the potential analgesic effects of minimally invasive brain stimulation. However, few studies have systematically investigated the potential benefits associated with combining approaches. The goal of this pilot laboratory study was to investigate the combination of a brief cognitive restructuring intervention and transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex in affecting pain tolerance...
April 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28445200/the-nasal-tip-rotation-flap-for-reconstruction-of-the-lateral-nasal-tip-anterior-ala-and-soft-triangle-the-authors-experience-with-55-patients
#15
Anastasia Benoit, S Tyler Hollmig, Brian C Leach
BACKGROUND: Defects of the lateral nasal tip, anterior ala, and soft triangle subunits lack reconstructive options that are consistently satisfactory. For such defects, the novel anterior-based nasal tip rotation flap provides functional and aesthetic results in a single operative session. OBJECTIVE: To describe the authors' experience with the nasal tip rotation flap, including patient selection and design modifications to enhance aesthetic success. METHODS: An IRB-approved retrospective database review of nasal tip rotation flap repairs was performed at the Medical University of South Carolina and Stanford University Medical Center...
October 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28397537/titanium-ossicular-chain-reconstruction-revision-success-and-preoperative-factors-predicting-success
#16
Phong T Le, Brendan P O'Connell, Andrew B Baker, Robert G Keller, Paul R Lambert
Objective Determine rates of success after revision titanium ossicular chain reconstruction with either partial or total ossicular replacement prosthesis and assess preoperative factors predicting positive outcomes. Study Design Case series with planned data collection. Setting Tertiary hospital. Subjects and Methods The charts of 76 surgical patients who underwent revision titanium ossicular chain reconstruction from 2003 to 2014 were abstracted from a prospectively maintained database at the Medical University of South Carolina...
July 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28274987/the-university-of-north-carolina-medical-center-pharmacy-resident-leadership-certificate-program
#17
Kayley Lyons, Danielle Griggs, Rachel Lebovic, Mary E Roth, David A South, Chad Hatfield
PURPOSE: The development and implementation of a certificate program for pharmacy residents are described. SUMMARY: University of North Carolina (UNC) Medical Center met the call for increased efforts in the area of pharmacy residency leadership training through the design, implementation, and evaluation of a leadership certificate program. The purpose of the UNC certificate program is to develop leaders who will serve others, improve their communities, and advance the profession...
March 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28249070/association-between-baseline-corticothalamic-mediated-inhibitory-control-and-smoking-relapse-vulnerability
#18
Brett Froeliger, Patrick A McConnell, Spencer Bell, Maggie Sweitzer, Rachel V Kozink, Christie Eichberg, Matt Hallyburton, Nicole Kaiser, Kevin M Gray, F Joseph McClernon
Importance: Tobacco use disorder is associated with dysregulated neurocognitive function in the right inferior frontal gyrus (IFG)-one node in a corticothalamic inhibitory control (IC) network. Objective: To examine associations between IC neural circuitry structure and function and lapse/relapse vulnerability in 2 independent studies of adult smokers. Design, Setting, and Participants: In study 1, treatment-seeking smokers (n = 81) completed an IC task during functional magnetic resonance imaging (fMRI) before making a quit attempt and then were followed up for 10 weeks after their quit date...
April 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28170316/medical-university-of-south-carolina-telestroke-a-telemedicine-facilitated-network-for-stroke-treatment-in-south-carolina-a-progress-report
#19
Sami Al Kasab, Robert J Adams, Ellen Debenham, David J Jones, Christine Ann Holmstedt
BACKGROUND: Patients in rural communities lack access to acute stroke therapies. Rapid administration of lytic therapy increases the likelihood of favorable functional outcome in acute ischemic stroke (AIS). At the Medical University of South Carolina (MUSC), we implemented a Web-based telestroke program that allows patients presenting with AIS at a rural hospital to receive expert stroke consultation within minutes. This increases their chances of receiving lytic therapy, and therefore increases the likelihood of good functional outcome...
August 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28146243/effect-of-a-brief-memory-updating-intervention-on-smoking-behavior-a-randomized-clinical-trial
#20
RANDOMIZED CONTROLLED TRIAL
Lisa J Germeroth, Matthew J Carpenter, Nathaniel L Baker, Brett Froeliger, Steven D LaRowe, Michael E Saladin
Importance: Recent research on addiction-related memory processes suggests that protracted extinction training following brief cue-elicited memory retrieval (ie, retrieval-extinction [R-E] training) can attenuate/eradicate the ability of cues to elicit learned behaviors. One study reported that cue-elicited craving among detoxified heroin addicts was substantially attenuated following R-E training and through 6-month follow-up. Objective: To build on these impressive findings by examining whether R-E training could attenuate smoking-related craving and behavior...
March 1, 2017: JAMA Psychiatry
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