Timur Kolomin, Marina Morozova, Anastasiya Volkova, Maria Shadrina, Lyudmila Andreeva, Petr Slominsky, Svetlana Limborska, Nikolay Myasoedov
Previous studies have shown that synthetic tuftsin analogue Selank and its fragments cause a number of alterations in the expression of certain genes involved in inflammation in mouse spleen. In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method. We found a significant 3-fold decrease in the C3 mRNA level just 30 min after Selank injection and similar alteration this gene mRNA level after Gly-Pro administration...
March 2014: Molecular Immunology