keyword
MENU ▼
Read by QxMD icon Read
search

Selank

keyword
https://www.readbyqxmd.com/read/27878720/selank-inhibits-ethanol-induced-hyperlocomotion-and-manifestation-of-behavioral-sensitization-in-dba-2-mice
#1
L G Kolik, A V Nadorova, S B Seredenin
The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the development of ethanol-induced (2.0 g/kg intraperitoneally) hyperlocomotion, in contrast to σ1-receptors agonist Afobazole (1.0 mg/kg, intraperitoneally) that did not inhibit ethanol-induced behavioral stimulation...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/26924987/selank-administration-affects-the-expression-of-some-genes-involved-in-gabaergic-neurotransmission
#2
Anastasiya Volkova, Maria Shadrina, Timur Kolomin, Lyudmila Andreeva, Svetlana Limborska, Nikolay Myasoedov, Petr Slominsky
Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this hypothesis we studied the effect of Selank and GABA on the expression of genes involved in neurotransmission. We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/26356395/-optimization-of-the-treatment-of-anxiety-disorders-with-selank
#3
RANDOMIZED CONTROLLED TRIAL
V E Medvedev, O N Tereshchenko, N V Kost, A Yu Ter-Israelyan, E V Gushanskaya, I K Chobanu, O Yu Sokolov, N F Myasoedov
AIM: To compare the efficacy and tolerability of monotherapy with phenazepam to complex treatment with the peptide preparation selank and phenazepam in patients with anxiety disorders. MATERIAL AND METHODS: Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/25850296/-effect-of-tripeptide-pro-gly-pro-on-rat-brain-transcriptome-in-focal-ischemia
#4
E V Medvedeva, V G Dmitrieva, O V Povarova, S A Limborskaia, V I Skvortsova, N F Miasoedov, L V Dergunova
Biologically active regulatory peptide, tripeptide Pro-Gly-Pro (PGP) was used as C-terminal fragment for peptide drugs Semax and Selank. In recent years the independent effects of PGP were observed. The question was raised, whether PGP contributes to the effects ofpeptide drugs containing PGP as a fragment. The genome-wide analysis was performed to investigate the influence of PGP on the transcriptome of ischemic rat brain cortex tissues. The gene expression alterations caused by the action of the tripeptide PGP were compared with the gene expression of the control group "ischemia" at 3 and 24 h after permanent occlusion of left middle cerebral artery...
March 2014: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/25371249/the-influence-of-selank-on-the-parameters-of-the-hemostasis-system-lipid-profile-and-blood-sugar-level-in-the-course-of-experimental-metabolic-syndrome
#5
N F Mjasoedov, L A Andreeva, M E Grigorjeva, T Y Obergan, T A Shubina, L A Lyapina
No abstract text is available yet for this article.
September 2014: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/25176261/-a-comparison-of-the-anxiolytic-effect-and-tolerability-of-selank-and-phenazepam-in-the-treatment-of-anxiety-disorders
#6
COMPARATIVE STUDY
V E Medvedev, O N Tereshchenko, A Iu Israelian, I K Chobanu, N V Kost, O Iu Sokolov, N F Miasoedov
Objective. To study the efficacy and tolerability of the new anxyolytic peptide selank in comparison with phenazepam. Material and methods. A comparative study of the anxiolytic effect and tolerability of selank and phenazepam was carried out in 60 patients with phobic-anxiety- and somatoform disorders (F40.2-9, F41.1-9, F45.0-1 by ICD-10) were examined. Results Pronounced anxiolytic and mild nootropic effects of selank were demonstrated. The anxiolytic effect lasted for a week after last receiving the peptide...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/24913576/efficacy-of-peptide-anxiolytic-selank-during-modeling-of-withdrawal-syndrome-in-rats-with-stable-alcoholic-motivation
#7
L G Kolik, A V Nadorova, M M Kozlovskaya
We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks. In alcohol-preferring animals (mean daily ethanol intake >5.0 g/kg) allowed free choice between 10 % ethanol and water, single intraperitoneal injection of selank in a dose of 0.3 mg/kg eliminated anxiety induced by ethanol withdrawal in tests elevated plus maze and social interaction tests and prevented the formation of mechanical allodynia without affecting ethanol consumption...
May 2014: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/24605419/-protective-effect-of-selank-on-the-model-of-mnestic-function-violation-induced-by-pharmacological-blockade-of-protein-synthesis
#8
I I Kozlovskiĭ, F Iu Belozertsev, L A Andreeva, M M Kozlovskaia
We have studied the ability of peptide anxiolytic selank (Thr-Lyz-Pro-Arg-Pro-Gly-Pro) to compensate for mnestic dysfunction caused by the administration of actinomycin D, which inhibits protein synthesis by blocking DNA-dependent RNA polymerase. The experiments were performed on white rats with acquired adaptive ability of spatial visual orientation in a 16-door labyrinth. The learning was based on the avoidance of electric skin irritation at alternating sites of escape reaction (site reflex). Selank (0.5 mg/kg, i...
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/24450168/-transcriptome-alteration-in-hippocampus-under-the-treatment-of-tuftsin-analog-selank
#9
T A Kolomin, T Iu Agapova, Ia V Agniullin, S I Shram, M I Shadrina, P A Slominskiĭ, S A Limborskaia, I F Miasoedov
The effect of single and course administration of Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the dose 200 microg/kg on the rat hippocampus transcriptional profile were studied using cDNA microarray technology. It was shown that mRNA levels of 36 genes changed more than 2-fold after a single intranasal Selank administration, and 20 genes--after course administration. It should be noted that most of them encode proteins associated with the plasma membrane (including transmembrane proteins). This suggests that Selank is able to regulate ion homeostasis of hippocampal cells and thereby modulate different ion-dependent processes, which include the processes of learning and memory formation...
May 2013: Zhurnal Vyssheĭ Nervnoĭ Deiatelnosti Imeni I P Pavlova
https://www.readbyqxmd.com/read/24291245/the-temporary-dynamics-of-inflammation-related-genes-expression-under-tuftsin-analog-selank-action
#10
Timur Kolomin, Marina Morozova, Anastasiya Volkova, Maria Shadrina, Lyudmila Andreeva, Petr Slominsky, Svetlana Limborska, Nikolay Myasoedov
Previous studies have shown that synthetic tuftsin analogue Selank and its fragments cause a number of alterations in the expression of certain genes involved in inflammation in mouse spleen. In this work we studied the effect of Selank and its short fragment Gly-Pro on the temporary dynamics of C3, Casp1, Il2rg, and Xcr1 genes expression in mouse spleen after single intraperitoneal injection (100 μg/kg) of peptides using real-time PCR method. We found a significant 3-fold decrease in the C3 mRNA level just 30 min after Selank injection and similar alteration this gene mRNA level after Gly-Pro administration...
March 2014: Molecular Immunology
https://www.readbyqxmd.com/read/22827026/-effect-of-selank-on-the-main-carboxypeptidases-in-the-rat-nervous-tissue
#11
(no author information available yet)
Effect of single selank administration on activity of carboxypeptidase H and of phenylmethylsulfonylfluoride-inhibited carboxypeptidase - enzymes detaching arginine and lysine from C-terminus of molecules-precursors of biologically active peptides was studied. The preparation has been shown to cause long, preserved for 24 h changes of activities of these carboxypeptidases. It is suggested that the change in activity of the studied enzymes can be one of mechanisms of regulation of level of neuropeptides at action of selank...
May 2012: Zhurnal Evoliutsionnoĭ Biokhimii i Fiziologii
https://www.readbyqxmd.com/read/22550852/-the-role-of-opioid-system-in-peculiarities-of-anti-anxiety-effect-of-peptide-anxiolytic-selank
#12
I I Kozlovskiĭ, L A Andreeva, M M Kozlovskaia, A V Nadorova, L G Kolik
Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test...
2012: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/22390072/-peptidergic-modulation-of-the-hippocampus-synaptic-activity
#13
V G Skrebitskiĭ, R V Kondratenko, I S Povarov, V I Dereviagin
Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells...
November 2011: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/21786679/-changes-in-expression-of-the-genes-for-chemokines-cytokines-and-their-receptors-in-response-to-selank-and-its-fragments
#14
T A Kolomin, M I Shadrina, P A Slominskiĭ, S A Limborskaia, N F Miasoedov
A study of the immunomodulating effect of selank showed that the total peptide and its fragment significantly change the expression of the genes for chemokines, cytokines, and their receptors in mouse spleen 6 and 24 h after administration of a single dose. Changes in the mRNA level of the majority of the genes under study were similarly observed after the administration of Gly-Pro, which was earlier identified as a selank pharmacophor, a minimum fragment with anitiviral activity. Pharmacological preparations based on endogenous regulatory peptides are studied intensely because they are the most promising class of drugs and have almost no side effects...
May 2011: Genetika
https://www.readbyqxmd.com/read/21609736/expression-of-inflammation-related-genes-in-mouse-spleen-under-tuftsin-analog-selank
#15
Timur Kolomin, Maria Shadrina, Lyudmila Andreeva, Petr Slominsky, Svetlana Limborska, Nikolay Myasoedov
Previous studies have shown that synthetic tuftsin analogue Selank causes a transcriptomic response in the rat hippocampus and in spleen cells and may participate in the regulation of inflammatory processes in the body. In this work we studied the effect of Selank and two of its fragments on the expression of genes involved in processes of inflammation. We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method...
October 10, 2011: Regulatory Peptides
https://www.readbyqxmd.com/read/20919548/-experimental-optimization-of-learning-and-memory-processes-by-selank
#16
T P Semenova, I I Kozlovskiĭ, N M Zakharova, M M Kozlovskaia
The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats. The animals were trained with food reward in 30 trials per day. Selank (300 microg/kg) or saline were injected after the 10th trial. Elaboration of conditioned reflex with food reward was continued 30 min later. Retention was tested 24 h, 7 and 30 days after treatment...
August 2010: Eksperimental'naia i Klinicheskaia Farmakologiia
https://www.readbyqxmd.com/read/20873405/-experimental-hemorrhagic-stroke-the-study-of-neuropeptides-mif-selank-in-the-intraperitoneal-injection
#17
V I Skvortsova, T V Tvorogova, A I Dubina, D V Burenchev, L V Gubskiĭ, L V Stakhovskaia, O V Povarova
The aim of this study was to examine Taftsin derivates--macrophage inhibitory factor (MIF, Thr-Lys-Pro) and heptapeptide selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) in the model of experimental intracerebral hemorrhage in rats. The double autologous blood injection in the basal nucleus was used as a model of intracerebral hemorrhage. Animals ware randomly divided into three groups--the control group (n = 5) was treated with saline, the second group (n = 5) was injected with MIF in dose 150 mkg/ kg/day, the third group (n = 5) received Selank in dose 300 mkg/kg/day...
2009: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/20506839/antiviral-properties-of-structural-fragments-of-the-peptide-selank
#18
L A Andreeva, I Yu Nagaev, M V Mezentseva, I M Shapoval, R Ya Podchernyaeva, V E Shcherbenko, L A Potapova, L I Russu, F I Ershov, N F Myasoedov
No abstract text is available yet for this article.
March 2010: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/20380151/transcriptomic-response-of-rat-hippocampus-and-spleen-cells-to-single-and-chronic-administration-of-the-peptide-selank
#19
T A Kolomin, M I Shadrina, Ya V Agniullin, S I Shram, P A Slominskii, S A Limborska, N F Myasoedov
No abstract text is available yet for this article.
January 2010: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/19882898/-antiviral-activity-of-immunomodulator-selank-in-experimental-influenza-infection
#20
F I Ershov, P N Uchakin, O N Uchakina, M V Mezentseva, L A Alekseeva, N F Miasoedov
The main objective of this study was to evaluate the antiviral properties of the glyproline Selank in both in vitro and in vivo against the influenza virus strain A/Aichi 2/68 (H3N2). The pronounced antiviral effect of the agent was detected in both systems. Selank added to the cell culture 24 hours before inoculation (a preventive use scheme) showed the highest efficiency, by completely suppressing viral reproduction. The in vivo studies also demonstrated that the highest survival of laboratory animals was observed when the agent was administered by the prevention scheme...
September 2009: Voprosy Virusologii
keyword
keyword
95067
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"