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https://www.readbyqxmd.com/read/29040674/evaluation-of-apoptotic-and-autophagic-related-protein-expressions-before-and-after-in-vitro-maturation-of-fresh-slow-frozen-and-vitrified-pre-pubertal-mouse-testicular-tissue
#1
L Dumont, F Chalmel, A Oblette, B Berby, A Rives, V Duchesne, C Rondanino, N Rives
STUDY QUESTION: Do freezing and in vitro culture procedures enhance the expression of proteins involved in apoptotic or autophagic pathways in murine pre-pubertal testicular tissue? SUMMARY ANSWER: In vitro maturation strongly modified apoptosis- and autophagy-related relative protein levels in mice testicular tissue whereas the impact of cryopreservation procedures was minimal at the end of the culture. WHAT IS KNOWN ALREADY: In vitro spermatogenesis remains a challenging technical issue as it imposes to find a very close balance between survival and death of germ cell natural precursors (i...
October 11, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29040500/chlamydia-trachomatis-plasmid-encoded-protein-porf5-protects-mitochondrial-function-by-inducing-mitophagy-and-increasing-hmgb1-expression
#2
Wenbo Lei, Qun Li, Shengmei Su, Jichang Bu, Qiulin Huang, Zhongyu Li
Chlamydia trachomatis, an obligate intracellular pathogen, has various effective strategies to regulate host cell death signalling pathways that ensure completion of their growth cycle. Mitochondrial autophagy (mitophagy) is responsible for elimination of dysfunctional and impaired mitochondria, and this process plays a critical role in cell survival via restriction of the mitochondrial apoptotic pathway. However, the specific molecular mechanisms are not entirely understood. In the present study, we observed that pORF5 plasmid protein of C...
October 11, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29040401/a-young-blood-environment-decreases-aging-of-senile-mice-kidneys
#3
Qi Huang, Yichun Ning, Dong Liu, Ying Zhang, Diangeng Li, Yinping Zhang, Zhong Yin, Bo Fu, Guangyan Cai, Xuefeng Sun, Xiangmei Chen
Whether changes in internal body environment affect kidney aging remains unclear. Specifically, it is unknown whether transplanted kidneys from older donors recover from tissue damage after placement in younger recipients. In this study, a parabiosis animal model was established to investigate the effects of a young internal body environment on aged kidneys. The animals were divided into six groups: young (Ycon) and old (Ocon) control groups, isochronic youth-youth group (Y-IP), elderly-elderly group (O-IP) and heterochronic youth (Y-HP) elderly (O-HP) group...
October 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29040052/partial-or-entire-distinct-responses-of-two-types-of-chloroplast-autophagy
#4
Masanori Izumi, Sakuya Nakamura
Autophagy carries out intracellular degradation of cytoplasmic components, which is important for the removal of dysfunctional organelles and for efficient nutrient recycling in eukaryotic cells. Most proteins in plant green tissues are found in chloroplasts, mainly as photosynthetic proteins that constantly accumulate damage caused by sunlight. Our recent study investigated the involvement of autophagy in the turnover of damaged chloroplasts and found that entire photodamaged chloroplasts are transported into the vacuole for degradation via an autophagy process termed chlorophagy...
October 17, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29036897/inhibition-of-starvation-triggered-endoplasmic-reticulum-stress-autophagy-and-apoptosis-in-arpe-19-cells-by-taurine-through-modulating-the-expression-of-calpain-1-and-calpain-2
#5
Yuanyuan Zhang, Shu Ren, Yuci Liu, Kun Gao, Zheng Liu, Zhou Zhang
Age-related macular degeneration (AMD) is a complex disease with multiple initiators and pathways that converge on death for retinal pigment epithelial (RPE) cells. In this study, effects of taurine on calpains, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in ARPE-19 cells (a human RPE cell line) were investigated. We first confirmed that autophagy, ER stress and apoptosis in ARPE-19 cells were induced by Earle's balanced salt solution (EBSS) through starvation to induce RPE metabolic stress...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29036763/effect-of-treadmill-exercise-on-skeletal-muscle-autophagy-in-rats-with-obesity-induced-by-a-high-fat-diet
#6
Do Keun Cho, Dong Hun Choi, Joon Yong Cho
PURPOSE: This study aimed to investigate the effects of treadmill exercise on body weight, blood biochemistry, and autophagy. METHODS: Triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, insulin, and glucose levels were measured, the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated, and the soleus muscle was analyzed for autophagy-related factors (Beclin-1, p62, LC3, Lamp-2) in rats with obesity induced by a high-fat diet...
September 30, 2017: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29036556/deficit-in-pink1-parkin-mediated-mitochondrial-autophagy-at-late-stages-of-dystrophic-cardiomyopathy
#7
Chifei Kang, Myriam A Badr, Viktoriia Kyrychenko, Eeva-Liisa Eskelinen, Natalia Shirokova
Aims: Duchenne Muscular Dystrophy (DMD) is an inherited devastating muscle disease with severe and often lethal cardiac complications. Emerging evidence suggests that the evolution of the pathology in DMD is accompanied by the accumulation of mitochondria with defective structure and function. Here we investigate whether defects in the housekeeping autophagic pathway contribute to mitochondrial and metabolic dysfunctions in dystrophic cardiomyopathy. Methods and results: We employed various biochemical and imaging techniques to assess mitochondrial structure and function as well as to evaluate autophagy, and specific mitochondrial autophagy (mitophagy), in hearts of mdx mice, an animal model of DMD...
October 5, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29036449/resveratrol-attenuates-bone-cancer-pain-through-regulating-the-expression-levels-of-asic3-and-activating-cell-autophagy
#8
Haili Zhu, Jieqiong Ding, J Wu, Tingting Liu, Jing Liang, Qiong Tang, Ming Jiao
Bone cancer pain (BCP) is one of the most common pains in patients with malignant cancers. The mechanism underlying BCP is largely unknown. Our previous studies and the increasing evidence both have shown that acid-sensing ion channels 3 (ASIC3) is an important protein in the pathological pain state in some pain models. We hypothesized that the expression change of ASIC3 might be one of the factors related to BCP. In this study, we established the BCP model through intrathecally injecting rat mammary gland carcinoma cells (MRMT-1) into the left tibia of Sprague-Dawley female rats, and found that the BCP rats showed bone destruction, increased mechanical pain sensitivities and up-regulated ASIC3 protein expression levels in L4-L6 dorsal root ganglion...
October 3, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29036428/exocyst-exosomes-and-autophagy-in-the-regulation-of-brassicaceae-pollen-stigma-interactions
#9
Daphne R Goring
Brassicaceae pollen-stigma interactions have been extensively studied in Brassica and Arabidopsis species to identify cellular events triggered in the stigmatic papillae by pollen contact. Compatible pollinations are linked to the activation of basal cellular responses in the stigmatic papillae, which include calcium gradients, actin networks, and polarized secretion. The occurrence of these cellular events in stigmatic papillae coincides with the stages of pollen hydration and pollen tube entry into the stigmatic papillar cell wall...
September 27, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29036202/toxoplasma-gondii-induces-fak-src-stat3-signaling-during-infection-of-host-cells-that-prevents-parasite-targeting-by-autophagy
#10
Jose-Andres C Portillo, Luis Muniz-Feliciano, Yalitza Lopez Corcino, So Jung Lee, Jennifer Van Grol, Sarah J Parsons, William P Schiemman, Carlos S Subauste
Targeting of Toxoplasma gondii by autophagy is an effective mechanism by which host cells kill the protozoan. Thus, the parasite must avoid autophagic targeting to survive. Here we show that the mammalian cytoplasmic molecule Focal Adhesion Kinase (FAK) becomes activated during invasion of host cells. Activated FAK appears to accompany the formation of the moving junction (as assessed by expression the parasite protein RON4). FAK activation was inhibited by approaches that impaired β1 and β3 integrin signaling...
October 16, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29036198/the-homeodomain-interacting-protein-kinase-hpk-1-preserves-protein-homeostasis-and-longevity-through-master-regulatory-control-of-the-hsf-1-chaperone-network-and-torc1-restricted-autophagy-in-caenorhabditis-elegans
#11
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protein aggregation diseases of the nervous system. A decline in proteostasis can be delayed through the activation of cytoprotective transcriptional responses, which are sensitive to environmental stress and internal metabolic and physiological cues...
October 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29035972/hyperammonemia-and-proteostasis-in-cirrhosis
#12
Srinivasan Dasarathy, Maria Hatzoglou
PURPOSE OF REVIEW: Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease. RECENT FINDINGS: Increased skeletal muscle uptake of ammonia initiates responses that result in disordered proteostasis including impaired protein synthesis and increased autophagy...
October 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29035891/inhibiting-ros-tfeb-dependent-autophagy-enhances-salidroside-induced-apoptosis-in-human-chondrosarcoma-cells
#13
Wei Zeng, Tao Xiao, Anlie Cai, Weiliang Cai, Huanhuan Liu, Jingling Liu, Jie Li, Miduo Tan, Li Xie, Ying Liu, Xiangcheng Yang, Yi Long
BACKGROUND/AIMS: Autophagy modulation has been considered a potential therapeutic strategy for human chondrosarcoma, and a previous study indicated that salidroside exhibits significant anti-carcinogenic activity. However, the ability of salidroside to induce autophagy and its role in human chondrosarcoma cell death remains unclear. METHODS: We exposed SW1353 cells to different concentrations of salidroside (0.5, 1 and 2 mM) for 24 h. RT-PCR, Western-blotting, Immunocytofluorescence, and Luciferase Reporter Assays were used to evaluate whether salidroside activated the TFEB-dependent autophagy...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29035876/hydrogen-gas-attenuates-myocardial-ischemia-reperfusion-injury-independent-of-postconditioning-in-rats-by-attenuating-endoplasmic-reticulum-stress-induced-autophagy
#14
Yunan Gao, Hongxiao Yang, Jing Chi, Qiannan Xu, Luqi Zhao, Weijia Yang, Weifan Liu, Wei Yang
BACKGROUND/AIMS: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats. METHODS: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH2) and the ischemic postconditioning plus hydrogen group (IPoH2). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29035754/regulation-of-autophagy-factors-by-oxidative-stress-and-cardiac-enzymes-imbalance-during-arsenic-or-and-copper-induced-cardiotoxicity-in-gallus-gallus
#15
Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Bangyi Wang, Yulong Wang, Mingwei Xing
Basal autophagy has an indispensable role in the functioning and maintenance of cardiac geometry under physiological conditions. Recently, increasing evidence has demonstrated that arsenic (As)/copper (Cu) play important roles in the autophagy of the heart. The current study was to evaluate whether oxidative damage by As or/and Cu was correlated with autophagy through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the heart of birds. Arsenic trioxide (30mg/kg) or/and cupric sulfate (300mg/kg) were administered in a basal diet to male Hy-line chickens (one-day-old) for 12 weeks...
October 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29034767/in-search-of-a-converging-cellular-mechanism-in-nanotoxicology-and-nanomedicine-in-the-treatment-of-cancer
#16
Mary Gulumian, Charlene Andraos
Multiple applications of nanomaterials have raised concern with regard to their toxicity. With increasing research into nanomaterial safety, mechanisms involved in the toxic effects of nanomaterials have begun to emerge. The importance of nanomaterial-induced lysosomal membrane permeabilization through overloading or direct damage of the lysosomal compartment, resulting in the blockade of autophagosome-lysosome fusion and autophagy dysfunction, as well as inflammasome activation were cited as emerging mechanisms of nanomaterial toxicity...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29034071/apigenin-in-cancer-therapy-anti-cancer-effects-and-mechanisms-of-action
#17
REVIEW
Xiaohui Yan, Miao Qi, Pengfei Li, Yihong Zhan, Huanjie Shao
Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological functions, such as strong anti-inflammatory, antioxidant, antibacterial and antiviral activities and blood pressure reduction. Therefore, apigenin has been used as a traditional medicine for centuries. Recently, apigenin has been widely investigated for its anti-cancer activities and low toxicity. Apigenin was reported to suppress various human cancers in vitro and in vivo by multiple biological effects, such as triggering cell apoptosis and autophagy, inducing cell cycle arrest, suppressing cell migration and invasion, and stimulating an immune response...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29033794/dihydroartemisinin-exerts-anti-tumor-activity-by-inducing-mitochondrion-and-endoplasmic-reticulum-apoptosis-and-autophagic-cell-death-in-human-glioblastoma-cells
#18
Chengbin Qu, Jun Ma, Xiaobai Liu, Yixue Xue, Jian Zheng, Libo Liu, Jing Liu, Zhen Li, Lei Zhang, Yunhui Liu
Glioblastoma (GBM) is the most advanced and aggressive form of gliomas. Dihydroartemisinin (DHA) has been shown to exhibit anti-tumor activity in various cancer cells. However, the effect and molecular mechanisms underlying its anti-tumor activity in human GBM cells remain to be elucidated. Our results proved that DHA treatment significantly reduced cell viability in a dose- and time-dependent manner by CCK-8 assay. Further investigation identified that the cell viability was rescued by pretreatment either with Z-VAD-FMK, 3-methyladenine (3-MA) or in combination...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29033400/protective-effects-of-luteolin-7-o-glucoside-against-starvation-induced-injury-through-upregulation-of-autophagy-in-h9c2-cells
#19
Hong Yao, Lichun Zhou, Linlin Tang, Yanhui Guan, Shang Chen, Yu Zhang, Xiuzhen Han
Cardiomyocyte nutrient deprivation is a common clinical event that mediates various cardiac ischemic processes and is associated with autophagy activation and cell survival or death. Luteolin-7-O-glucoside (LUTG) was one of the flavonoid glycosides isolated from Dracocephalum tanguticum. Previous research had showed that LUTG pretreatment had significant protective effects against doxorubicin-induced cardiotoxicity. However, whether LUTG could protect cardiomyocytes from starvation-induced injury was not clear...
October 16, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29033323/mtorc1-phosphorylates-acetyltransferase-p300-to-regulate-autophagy-and-lipogenesis
#20
Wei Wan, Zhiyuan You, Yinfeng Xu, Li Zhou, Zhunlv Guan, Chao Peng, Catherine C L Wong, Hua Su, Tianhua Zhou, Hongguang Xia, Wei Liu
Acetylation is increasingly recognized as one of the major post-translational mechanisms for the regulation of multiple cellular functions in mammalian cells. Acetyltransferase p300, which acetylates histone and non-histone proteins, has been intensively studied in its role in cell growth and metabolism. However, the mechanism underlying the activation of p300 in cells remains largely unknown. Here, we identify the homeostatic sensor mTORC1 as a direct activator of p300. Activated mTORC1 interacts with p300 and phosphorylates p300 at 4 serine residues in the C-terminal domain...
October 11, 2017: Molecular Cell
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