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auditory brainstem response

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https://www.readbyqxmd.com/read/29151101/psychoacoustics-and-neurophysiological-alterations-after-30-36-hours-of-sleep-deprivation
#1
Adrián Poblano, Sergio Díaz-Leines, Olga Gama-Moreno, Blanca Flores-Avalos
BACKGROUND AND AIM: Sleep deprivation (SD) may result in perceptual and cognitive alterations in healthy subjects. Our objective was to compare whether psychoacoustics and neurophysiological variables in healthy subjects were altered after SD of 30-36 h. METHOD: We examined 22 subjects by means of several psychoacoustics tests, P300 and mismatch negativity (MMN) recordings, and brainstem auditory evoked potentials (BAEP) before and after 30-36 h of SD. RESULTS: In the psychoacoustics tests, we found that after SD, difficulties were experienced by the left ear in the discrimination of words in noise and by the right ear in music discrimination...
November 18, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/29138310/sparsity-enables-estimation-of-both-subcortical-and-cortical-activity-from-meg-and-eeg
#2
Pavitra Krishnaswamy, Gabriel Obregon-Henao, Jyrki Ahveninen, Sheraz Khan, Behtash Babadi, Juan Eugenio Iglesias, Matti S Hämäläinen, Patrick L Purdon
Subcortical structures play a critical role in brain function. However, options for assessing electrophysiological activity in these structures are limited. Electromagnetic fields generated by neuronal activity in subcortical structures can be recorded noninvasively, using magnetoencephalography (MEG) and electroencephalography (EEG). However, these subcortical signals are much weaker than those generated by cortical activity. In addition, we show here that it is difficult to resolve subcortical sources because distributed cortical activity can explain the MEG and EEG patterns generated by deep sources...
November 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29137881/comparison-between-chloral-hydrate-and-propofol-ketamine-as-sedation-regimens-for-pediatric-auditory-brainstem-response-testing
#3
Kamal Abulebda, Vinit J Patel, Sheikh S Ahmed, Alvaro J Tori, Riad Lutfi, Samer Abu-Sultaneh
INTRODUCTION: The use of diagnostic auditory brainstem response testing under sedation is currently the "gold standard" in infants and young children who are not developmentally capable of completing the test. OBJECTIVE: The aim of the study is to compare a propofol-ketamine regimen to an oral chloral hydrate regimen for sedating children undergoing auditory brainstem response testing. METHODS: Patients between 4 months and 6 years who required sedation for auditory brainstem response testing were included in this retrospective study...
October 28, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29135872/the-role-of-auditory-evoked-potentials-in-the-context-of-cochlear-implant-provision
#4
Sebastian Hoth, Oliver Christian Dziemba
: Auditory evoked potentials (AEP) are highly demanded during the whole process of equipping patients with cochlear implants (CI). They play an essential role in preoperative diagnostics, intraoperative testing, and postoperative monitoring of auditory performance and success. The versatility of AEP's is essentially enhanced by their property to be evokable by acoustic as well as electric stimuli. Thus, the electric responses of the auditory system following acoustic stimulation and recorded by the conventional surface technique as well as by transtympanic derivation from the promontory (Electrocochleography [ECochG]) are used for the quantitative determination of hearing loss and, additionally, electrically evoked compound actions potentials (ECAP) can be recorded with the intracochlear electrodes of the implant just adjacent to the stimulation electrode to check the functional integrity of the device and its coupling to the auditory system...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29130443/unraveling-the-mystery-of-auditory-brainstem-response-corrections-the-need-for-universal-standards
#5
REVIEW
Linda W Norrix, David Velenovsky
BACKGROUND: The auditory brainstem response (ABR) is used to estimate behavioral hearing thresholds in infants and difficult-to-test populations. Differences between the toneburst ABR and behavioral thresholds exist making the correspondence between the two measures less than perfect. Some authors have suggested that corrections be applied to ABR thresholds to account for these differences. However, because there is no agreed upon universal standard, confusion regarding the use of corrections exists...
November 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29122423/efferent-modulation-of-pre-neural-and-neural-distortion-products
#6
S B Smith, K Ichiba, D S Velenovsky, B Cone
Distortion product otoacoustic emissions (DPOAEs) and distortion product frequency following responses (DPFFRs) are respectively pre-neural and neural measurements associated with cochlear nonlinearity. Because cochlear nonlinearity is putatively linked to outer hair cell electromotility, DPOAEs and DPFFRs may provide complementary measurements of the human medial olivocochlear (MOC) reflex, which directly modulates outer hair cell function. In this study, we first quantified MOC reflex-induced DPOAE inhibition at spectral fine structure peaks in 22 young human adults with normal hearing...
October 26, 2017: Hearing Research
https://www.readbyqxmd.com/read/29121103/central-conduction-time-in-auditory-brainstem-response-and-ear-advantage-in-dichotic-listening-across-menstrual-cycle
#7
Xu-Jun Hu, Chi-Chuen Lau
The ovarian hormones fluctuate during the menstrual cycle in women. Such fluctuation of sex hormones, in particular estrogen, is believed to affect the central conduction time in auditory function as well as the language lateralization in cognitive function. However, findings are inconsistent. The underlying mechanisms are also unclear. This paper examined if there was any relation between the central conduction time and the language lateralization at different times during the menstrual cycle. Twenty young women with normal menstrual cycle were tested four times (5 to 7 days apart) across the menstrual cycle...
2017: PloS One
https://www.readbyqxmd.com/read/29111973/otoferlin-acts-as-a-ca-2-sensor-for-vesicle-fusion-and-vesicle-pool-replenishment-at-auditory-hair-cell-ribbon-synapses
#8
Nicolas Antoine Michalski, Juan D Goutman, Sarah Marie Auclair, Jacques Boutet de Monvel, Margot Tertrais, Alice Emptoz, Alexandre Parrin, Sylvie Nouaille, Marc Guillon, Martin Sachse, Danica Ciric, Amel Bahloul, Jean-Pierre Hardelin, Roger Bryan Sutton, Paul Avan, Shyam S Krishnakumar, James E Rothman, Didier Dulon, Saaid Safieddine, Christine Petit
Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This process requires otoferlin, a six C2-domain, Ca(2+)-binding transmembrane protein of synaptic vesicles. To decipher the role of otoferlin in the synaptic vesicle cycle, we produced knock-in mice (Otof(Ala515,Ala517/Ala515,Ala517)) with lower Ca(2+)-binding affinity of the C2C domain. The IHC ribbon synapse structure, synaptic Ca(2+) currents, and otoferlin distribution were unaffected in these mutant mice, but auditory brainstem response wave-I amplitude was reduced...
November 7, 2017: ELife
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#9
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29107847/the-fbn-rat-model-of-aging-investigation-of-abr-waveforms-and-ribbon-synapse-changes
#10
Rui Cai, Scott C Montgomery, Kaley A Graves, Donald M Caspary, Brandon C Cox
Age-related hearing loss is experienced by one-third of individuals aged 65 years and older and can be socially debilitating. Historically, there has been poor correlation between age-related threshold changes, loss of speech understanding, and loss of cochlear hair cells. We examined changes in ribbon synapse number at four different ages in Fisher Brown Norway rats, an extensively studied rat model of aging. In contrast to previous work in mice/Wistar rats, we found minimal ribbon synapse loss before 20 months, with significant differences in 24- and 28-month-old rats at 4 kHz...
October 9, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29106871/test-retest-reliability-of-speech-evoked-auditory-brainstem-response-in-healthy-children-at-a-low-sensation-level
#11
Mohd Normani Zakaria, Bahram Jalaei
OBJECTIVE: Auditory brainstem responses evoked by complex stimuli such as speech syllables have been studied in normal subjects and subjects with compromised auditory functions. The stability of speech-evoked auditory brainstem response (speech-ABR) when tested over time has been reported but the literature is limited. The present study was carried out to determine the test-retest reliability of speech-ABR in healthy children at a low sensation level. METHODS: Seventeen healthy children (6 boys, 11 girls) aged from 5 to 9 years (mean = 6...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29106852/postoperative-objective-detecting-techniques-for-cochlear-implant-children-with-inner-ear-malformation
#12
Xiao-Feng Qiao, Xin Li, Qiang-Wei Zhang, Tong-Li Li, Dong Wang
OBJECTIVES: This study aims to investigate the changing characteristics and rules of electrically-evoked auditory brainstem response (EABR), electrically-evoked stapedius reflex threshold (ESRT) and neural response telemetry (NRT) after cochlear implant in children with inner ear malformation, and guide postoperative equipment debug. METHODS: A total of 88 children with either normal cochlea (control group) or inner ear malformation (test group) received Australian 24 multi-channel cochlear implants...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29105620/loud-music-exposure-and-cochlear-synaptopathy-in-young-adults-isolated-auditory-brainstem-response-effects-but-no-perceptual-consequences
#13
John H Grose, Emily Buss, Joseph W Hall
The purpose of this study was to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear synaptopathy. Young adults with normal audiograms were recruited who either did ( n = 31) or did not ( n = 30) have a history of frequent attendance at loud music venues where the typical sound levels could be expected to result in temporary threshold shifts. A test battery was administered that comprised three sets of procedures: (a) electrophysiological tests including distortion product otoacoustic emissions, auditory brainstem responses, envelope following responses, and the acoustic change complex evoked by an interaural phase inversion; (b) psychoacoustic tests including temporal modulation detection, spectral modulation detection, and sensitivity to interaural phase; and (c) speech tests including filtered phoneme recognition and speech-in-noise recognition...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29098103/cochlear-implantation-in-patients-with-keratitis-ichthyosis-deafness-syndrome-a-report-of-two-cases
#14
Birgul Gumus, Armagan Incesulu, Mehmet Ozgur Pinarbasli
Background: Keratitis-ichthyosis-deafness (KID) syndrome is a syndrome which presents with hearing loss and visual and keratinization disorders. In such patients, hearing aids cannot be effectively used in the rehabilitation of hearing loss because of the frequent blockage of the external ear canal with epithelial debris and due to dry and tense skin of the external ear canal. Moreover, severe or profound hearing loss also limits the benefits gained from the conventional hearing aids...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29092803/the-protective-effect-of-cortexin-on-cisplatin-induced-ototoxicity
#15
Orkun Eroğlu, Turgut Karlıdağ, Tuncay Kuloğlu, Erol Keleş, İrfan Kaygusuz, Şinasi Yalçın
OBJECTIVE: The aim of this report is to evaluate whether cortexin provides any protective activity against ototoxicity of cisplatin. MATERIALS AND METHODS: The study was performed on 30 healthy adult Wistar Albino rats, and rats were randomly divided into three groups of ten. Group I (Control group) was given intraperitoneal (ip) saline solution 1 mL/day. Group II (Cisplatin group) was given ip cisplatin for 2 days at doses of 10 mg/kg. Group III (Cisplatin + Cortexin group) was given ip cisplatin for 2 days at same doses with ip cortexin 2 mg/day for 7 days...
November 2, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29092611/modeling-signal-propagation-in-the-human-cochlea
#16
Stephen T Neely, Daniel M Rasetshwane
The level-dependent component of the latency of human auditory brainstem responses (ABR) to tonebursts decreases by about 38% for every 20-dB increase in stimulus level over a wide range of both frequency and level [Neely, Norton, Gorga, and Jesteadt (1998). J. Acoust. Soc. Am. 31, 87-97]. This level-dependence has now been simulated in an active, nonlinear, transmission-line model of cochlear mechanics combined with an adaptation stage. The micromechanics in this model are similar to previous models except that a dual role is proposed for the tectorial membrane (TM): (1) passive sharpening the tuning of sensory-cell inputs (relative to basilar-membrane vibrations) and (2) providing an optimal phase shift (relative to basilar-membrane vibrations) of outer-hair-cell feedback forces, so that amplification is restricted to a limited range of frequencies...
October 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29089185/cannula-based-drug-delivery-to-the-guinea-pig-round-window-causes-a-lasting-hearing-loss-that-may-be-temporarily-mitigated-by-bdnf
#17
Phillip J P Sale, Aaron Uschakov, Tasfia Saief, David P Rowe, Carla J Abbott, Chi D Luu, Amy J Hampson, Stephen J O'Leary, David J Sly
Sustained local delivery of drugs to the inner ear may be required for future regenerative and protective strategies. The round window is surgically accessible and a promising delivery route. To be viable, a delivery system should not cause hearing loss. This study determined the effect on hearing of placing a drug-delivery microcatheter on to the round window, and delivering either artificial perilymph (AP) or brain-derived neurotrophic factor (BDNF) via this catheter with a mini-osmotic pump. Auditory brainstem responses (ABRs) were monitored for 4 months after surgery, while the AP or BDNF was administered for the first month...
October 28, 2017: Hearing Research
https://www.readbyqxmd.com/read/29081120/-role-of-green-tea-polyphenols-in-noise-induced-hearing-loss
#18
Y H Li, P S Jiang, Y W Su, Y M Liu
Objective: To investigate the role and mechanism of action of green tea polyphenols in noise-induced hearing loss. Methods: Male specific pathogen-free guinea pigs were randomly divided into normal control group with 9 guinea pigs, noise exposure group with 36 guinea pigs, and green tea polyphenol intervention group with 36 guinea pigs. Auditory brainstem response (ABR) threshold shift was examined before noise exposure and at 1, 3, 7, and 14 days of noise exposure. The surface preparation of cochlear basilar membrane was used for hair cell count and the morphology of hair cells was also observed...
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29076926/usefulness-of-electrical-auditory-brainstem-responses-to-assess-the-functionality-of-the-cochlear-nerve-using-an-intracochlear-test-electrode
#19
Luis Lassaletta, Marek Polak, Jan Huesers, Miguel Díaz-Gómez, Miryam Calvino, Isabel Varela-Nieto, Javier Gavilán
OBJECTIVE: To use an intracochlear test electrode to assess the integrity and the functionality of the auditory nerve in cochlear implant (CI) recipients and to compare electrical auditory brainstem responses (eABR) via the test electrode with the eABR responses with the CI. SETTING: Otolaryngology department, tertiary referral hospital. PATIENTS: Ten subjects (age at implantation 55 yr, range, 19-72) were subsequently implanted with a MED-EL CONCERTO CI on the side without any useful residual hearing...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29071963/-effect-of-electroacupuncture-on-expression-of-catechol-o-methyltransferase-in-the-inferior-colliculus-and-auditory-cortex-in-age-related-hearing-loss-guinea-pigs
#20
Shu-Yun Liu, Li-Qiang Deng, Ye Yang, Ze-Deng Yin
OBJECTIVE: To observe the expression of catechol-O-methyltransferase (COMT) in inferior colliculus and auditory cortex of guinea pigs with age-related hearing loss(AHL) induced by D-galactose, so as to explore the possible mechanism of electroacupuncture(EA) underlying preventing AHL. METHODS: Thirty 3-month-old guinea pigs were randomly divided into control group, model group and EA group(n=10 in each group), and ten 18-month-old guinea pigs were allocated as elderly group...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
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