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auditory brainstem response

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https://www.readbyqxmd.com/read/28432372/evaluation-of-the-auditory-pathway-in-traffic-policemen
#1
Vipul Indora, Farah Khaliq, Neelam Vaney
BACKGROUND: Traffic policemen working at heavy traffic junctions are continuously exposed to high level of noise and its health consequences. OBJECTIVE: To assess the hearing pathway in traffic policemen by means of brainstem evoked response audiometry (BERA), mid-latency response (MLR), and slow vertex response (SVR). METHODS: In this observational comparative study, BERA, MLR, and SVR were tested in 35 male traffic policemen with field posting of more than 3 years...
April 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28431617/short-term-outcome-of-functional-integrity-of-the-auditory-brainstem-in-term-infants-who-suffer-perinatal-asphyxia
#2
Ze D Jiang, Cao Chen
OBJECTIVES: To assess short-term outcome of impaired functional integrity of the auditory brainstem in term infants who suffer perinatal asphyxia. METHODS: Maximum length sequence brainstem auditory evoked response (MLS BAER) was recorded and analyzed at a mean age of 3months in term infants after perinatal asphyxia. The data were compared with age-matched normal term infants. RESULTS: The infants after asphyxia showed an increase in the latency of MLS BAER wave III at 91, 455 and 910/s, and wave V at all click rates of 91-910/s...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28420277/device-optimised-chirp-stimulus-for-abr-measurements-with-an-active-middle-ear-implant
#3
Mario Cebulla, Ute Geiger, Rudolf Hagen, Andreas Radeloff
OBJECTIVE: Active middle ear implants are widely used to treat adults and children with sensorineural, conductive, or mixed hearing loss. Currently, there is no adequate method to determine the performance of active middle ear implant systems. DESIGN: The proposed method is based on measuring the auditory brainstem response while stimulating the hearing system via the active middle ear implant (Vibrant Soundbridge(TM), VSB; MEDEL, Austria). The acoustic stimulation was achieved via an optimised chirp stimulus (CE-Chirp), implemented in the Eclipse system (Interacoustics, Denmark)...
April 19, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28415891/influence-of-two-electrode-montages-on-the-level-specific-ls-ce-chirp-auditory-brainstem-response-abr-at-multiple-intensity-levels
#4
Ahmad Aidil Arafat Dzulkarnain, Siti Hajra Mu'minah Noor Ibrahim, Nur Farah Aida Anuar, Siti Aisyah Abdullah, Tengku Zulaila Hasma Tengku Zam Zam, Sarah Rahmat, Muhammad Amar Mohd Ruzai
OBJECTIVE: To investigate the influence of two different electrode montages (ipsilateral: reference to mastoid and vertical: reference to nape of neck) to the ABR results recorded using a level-specific (LS)-CE-Chirp® in normally hearing subjects at multiple intensities levels. DESIGN: Quasi-experimental and repeated measure study designs were applied in this study. Two different stopping criteria were used, (1) a fixed-signal averaging 4000 sweeps and, (2) a minimum quality indicator of Fmp = 3...
April 18, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28414278/otoacoustic-emissions-in-young-children-with-autism
#5
Memduha Taş, Şule Yılmaz, Erdoğan Bulut, Zahra Polat, Abdullah Taş
OBJECTIVE: The aim of this study is to investigate otoacoustic emissions (OAEs) in young children with autism compared with those in an age-matched control group. MATERIALS AND METHODS: Thirty-eight children with autism aged 3-6 years and 27 typically developing (normally developing) control subjects participated in this study. All the participants had normal hearing and middle-ear function. Auditory brainstem responses were used to determine the hearing status in the autism group...
April 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28404559/surviving-murine-experimental-sepsis-affects-the-function-and-morphology-of-the-inner-ear
#6
Natalie Fischer, Nina Maria Mathonia, Georges Hoellerich, Julian Veser, Leyla Pinggera, Daniel Dejaco, Rudolf Glueckert, Anneliese Schrott-Fischer, Peter Lackner, Herbert Riechelmann, Joachim Schmutzhard
OBJECTIVE: Severe sepsis is known to result in various neurological long-term deficits in human. Recently, a link between severe, lethal sepsis and significant hearing loss with correlating histomorphological inner ear changes in mice (C57BL/6) was observed. However, if similar observations can be made in severe, non-lethal sepsis in mice is unclear. This study evaluates mice after severe, non-lethal sepsis for analogue functional and histomorphological alterations of the inner ear. MATERIALS AND METHODS: A total of 63 C57BL/6 mice were included in the study...
April 12, 2017: Biology Open
https://www.readbyqxmd.com/read/28395500/-advances-in-auditory-function-research-of-meniere-disease
#7
Y Zhang, B Liu
Meniere disease is a unique, progressive disease of the inner ear. The complex manifestation presents diagnostic challenges. It is difficult to diagnose due to the absence of typical presentations especially in the early stages. The cochlear symptoms often present prior to vertigo and tend to be ignored. Therefore, focusing on the cochlear symptoms and functions may provide information for early diagnosis and may protect the patients from acquiring a hearing disability. This review focused on the pure-tone audiometry, glycerin test, distortion product otoacoustic emissions, auditory brainstem response, electrocochleogram, multifrequency tympanometry, and speech audiometry, which hopefully could emphasize the importance of the symptomatic and functional findings of cochlear, and be helpful in diagnosis for Meniere disease...
March 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28395306/normative-study-of-wideband-acoustic-immittance-measures-in-newborn-infants
#8
Sreedevi Aithal, Joseph Kei, Venkatesh Aithal, Alehandrea Manuel, Joshua Myers, Carlie Driscoll, Asaduzzaman Khan
Objective: The purpose of this study was to describe normative aspects of wideband acoustic immittance (WAI) measures obtained from healthy White neonates. Method: In this cross-sectional study, wideband absorbance (WBA), admittance magnitude, and admittance phase were measured under ambient pressure condition in 326 ears from 203 neonates (M age = 45.9 hr) who passed a battery of tests, including automated auditory brainstem response, high-frequency tympanometry, and distortion product otoacoustic emissions...
April 10, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28371266/autism-spectrum-disorders-and-the-amplitude-of-auditory-brainstem-response-wave-i
#9
Mariline Santos, Cristina Marques, Ana Nóbrega Pinto, Raquel Fernandes, Miguel Bebiano Coutinho, Cecília Almeida E Sousa
To determine whether children with autism spectrum disorders (ASDs) have an increased number of wave I abnormal amplitudes in auditory brainstem responses (ABRs) than age- and sex-matched typically developing children. This analytical case-control study compared patients with ASDs between the ages of 2 and 6 years and children who had a language delay not associated with any other pathology. Amplitudes of ABR waves I and V; absolute latencies (ALs) of waves I, III, and V; and interpeak latencies (IPLs) I-III, III-IV, and I-V at 90 dB were compared between ASD patients and normally developing children...
April 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28365219/study-of-the-efficacy-of-melatonin-for-auditory-brainstem-response-abr-testing-in-children
#10
L Casteil, A Viquesnel, V Favier, N Guignard, C Blanchet, M Mondain
STUDY OBJECTIVE: To evaluate the efficacy of oral melatonin to induce sedation (natural sleep) while measuring auditory brainstem responses (ABR) in children with suspected hearing loss by calculating the ABR success rate with the use of melatonin, the percentage of children in whom sleep was induced by melatonin and the time required to perform complete ABR testing. MATERIAL AND METHODS: Twenty-nine children aged 1 to 6 years were included in this prospective study...
March 29, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28362376/a-comparative-study-of-drug-delivery-methods-targeted-to-the-mouse-inner-ear-bullostomy-versus-transtympanic-injection
#11
Silvia Murillo-Cuesta, Néstor Vallecillo, Rafael Cediel, Adelaida M Celaya, Luis Lassaletta, Isabel Varela-Nieto, Julio Contreras
We present two minimally invasive microsurgical techniques in rodents for specific drug delivery into the middle ear so that it may reach the inner ear. The first procedure consists of perforation of the tympanic bulla, termed bullostomy; the second one is a transtympanic injection. Both emulate human clinical intratympanic procedures. Chitosan-glycerophosphate (CGP) and Ringer´s Lactate buffer (RL) were used as biocompatible vehicles for local drug delivery. CGP is a nontoxic biodegradable polymer widely used in pharmaceutical applications...
March 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28361373/methylmercury-exposure-reduces-the-auditory-brainstem-response-of-zebra-finches-taeniopygia-guttata
#12
Sarah E Wolf, John P Swaddle, Daniel A Cristol, William J Buchser
Mercury contamination from mining and fossil fuel combustion causes damage to humans and animals worldwide. Mercury exposure has been implicated in mammalian hearing impairment, but its effect on avian hearing is unknown. In this study, we examined whether lifetime dietary mercury exposure affected hearing in domestic zebra finches (Taeniopygia guttata) by studying their auditory brainstem responses (ABRs). Zebra finches exposed to mercury exhibited elevated hearing thresholds, decreased amplitudes, and longer latencies in the ABR, the first evidence of mercury-induced hearing impairment in birds...
March 30, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28357188/audiological-findings-from-an-adult-with-thin-cochlear-nerves
#13
Prashanth Prabhu, Jyothi Shivaswamy
Reported here are audiological findings from an adult with thin cochlear nerves. Magnetic resonance imaging (MRI) revealed that he had a thinner cochlear nerve in the left ear than in the right ear. He had a higher degree of hearing loss in the left ear and poor speech recognition scores for both ears. He had normal middle ear and cochlear functioning. The auditory brainstem response and acoustic reflexes were absent, indicating a retrocochlear pathology. Long latency responses (LLR) revealed normal cortical functioning...
February 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28356138/can-floseal%C3%A2-be-applied-safely-during-otologic-surgery-assessment-of-ototoxicity-in-a-chinchilla-animal-model
#14
Carol Nhan, Aren Bezdjian, Abdullah Alarfaj, Sam J Daniel
BACKGROUND: In otologic surgery good visualization is paramount, and patients with bleeding diatheses or who need to be anti-coagulated can present a significant challenge. Here, we determine whether Floseal™, a hemostatic matrix, is ototoxic in a validated animal model. METHODS: Nine chinchillas housed in the animal care facilities of the Montreal Children's Hospital Research Institute were used for the study. After a myringotomy incision was made in each tympanic membrane, baseline auditory brainstem response measurements were performed at 8, 20, and 25 kHz...
March 29, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28345280/otoprotective-effects-of-mouse-nerve-growth-factor-in-dba-2j-mice-with-early-onset-progressive-hearing-loss
#15
Qingzhu Wang, Hongchun Zhao, Tihua Zheng, Wenjun Wang, Xiaolin Zhang, Andi Wang, Bo Li, Yanfei Wang, Qingyin Zheng
As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studied extensively for its ability to promote neuronal survival and growth. To determine whether mNGF can ameliorate progressive hearing loss (PHL) in DBA/2J mice, saline or mNGF was given to DBA/2J mice of either sex by daily intramuscular injection from the 1st to the 9th week after birth...
March 27, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28344103/evaluation-of-geranylgeranylacetone-against-cisplatin-induced-ototoxicity-by-auditory-brainstem-response-heat-shock-proteins-and-oxidative-levels-in-guinea-pigs
#16
Wu-Chia Lo, Chen-Tu Wu, Hillary Chiao Lee, Yi-Ho Young, Yih-Leong Chang, Po-Wen Cheng
This study aims to assess whether geranylgeranylacetone (GGA) could reduce ototoxicity induced by cisplatin through upregulation of not only heat shock protein(HSP)-70, but also HSP-27 and HSP-40, and to study if GGA would reduce cisplatin-induced increase in oxidative stress. 48 guinea pigs were used in this study and treated with the following regimen: 0.5% CMC (sodium carboxymethyl cellulose) control for 7days, GGA (600mg/kg/d) for 7days, a combination of GGA (600mg/kg) for 7days and then one dose of 10mg/kg cisplatin (GGA+Cis), and a combination of CMC for 7days and then 10mg/kg cisplatin (cisplatin group)...
March 24, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28344071/exposure-to-diphtheria-toxin-during-the-juvenile-period-impairs-both-inner-and-outer-hair-cells-in-c57bl-6-mice
#17
Hiroyuki Konishi, Nobutaka Ohgami, Aika Matsushita, Yuki Kondo, Yuki Aoyama, Masaaki Kobayashi, Taku Nagai, Shinya Ugawa, Kiyofumi Yamada, Masashi Kato, Hiroshi Kiyama
Diphtheria toxin (DT) administration into transgenic mice that express the DT receptor (DTR) under control of specific promoters is often used for cell ablation studies in vivo. Because DTR is not expressed in mice, DT injection has been assumed to be nontoxic to cells in vivo. In this study, we demonstrated that DT application during the juvenile stage leads to hearing loss in wild-type mice. Auditory brainstem response measurement showed severe hearing loss in C57BL/6 mice administered DT during the juvenile period, and the hearing loss persisted into adulthood...
March 24, 2017: Neuroscience
https://www.readbyqxmd.com/read/28335700/cochlear-implants-in-the-management-of-hearing-loss-in-neurofibromatosis-type-2
#18
Frances Harris, James R Tysome, Neil Donnelly, Juliette Durie-Gair, Gemma Crundwell, Yu Chuen Tam, Richard D Knight, Zebunnisa H Vanat, Nicola Folland, Patrick Axon
OBJECTIVE: Review of cochlear implant (CI) outcomes in patients with Neurofibromatosis Type 2 (NF2), implanted in the presence of an ipsilateral vestibular schwannoma (VS). Hearing restoration was combined in some cases with a Bevacizumab regime. METHOD: Retrospective review of 12 patients, managed over the period 2009-2016, at a tertiary referral multidisciplinary NF2 clinic. The patients are grouped by hearing outcomes to explore likely protective factors, and to generate a proposed decision-making tool for the selection of either CI or Auditory Brainstem Implant (ABI)...
May 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28323619/fast-spiking-gaba-circuit-dynamics-in-the-auditory-cortex-predict-recovery-of-sensory-processing-following-peripheral-nerve-damage
#19
Jennifer Resnik, Daniel B Polley
Cortical neurons remap their receptive fields and rescale sensitivity to spared peripheral inputs following sensory nerve damage. To address how these plasticity processes are coordinated over the course of functional recovery, we tracked receptive field reorganization, spontaneous activity, and response gain from individual principal neurons in the adult mouse auditory cortex over a 50-day period surrounding either moderate or massive auditory nerve damage. We related the day-by-day recovery of sound processing to dynamic changes in the strength of intracortical inhibition from parvalbumin-expressing (PV) inhibitory neurons...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28319479/brainstem-evoked-potential-indices-of-subcortical-auditory-processing-after-mild-traumatic-brain-injury
#20
Kathy R Vander Werff, Brian Rieger
OBJECTIVES: The primary aim of this study was to assess subcortical auditory processing in individuals with chronic symptoms after mild traumatic brain injury (mTBI) by measuring auditory brainstem responses (ABRs) to standard click and complex speech stimuli. Consistent with reports in the literature of auditory problems after mTBI (despite normal-hearing thresholds), it was hypothesized that individuals with mTBI would have evidence of impaired neural encoding in the auditory brainstem compared to noninjured controls, as evidenced by delayed latencies and reduced amplitudes of ABR components...
March 17, 2017: Ear and Hearing
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