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https://www.readbyqxmd.com/read/29453558/inorganic-nanoparticles-in-diagnosis-and-treatment-of-breast-cancer
#1
REVIEW
Cristina Núñez, Sergio Vázquez Estévez, María Del Pilar Chantada
Nanoparticles are being actively developed for biomolecular profiling of cancer biomarkers, tumor imaging in vivo, and targeted drug delivery. These nanotechnology-based techniques can be applied widely in the management of different malignant diseases, such as breast cancer. Although the number of different types of nanoparticles is increasing rapidly, most can be classified into two major types: particles that contain organic molecules as a major building material (such as dendrimers, micelles, liposomes and carbon nanotubes, and other polymers); and those that use inorganic elements, usually metals, as a core...
February 16, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29453543/toxic-and-beneficial-potential-of-silver-nanoparticles-the-two-sides-of-the-same-coin
#2
Lilian Rodrigues Rosa Souza, Veronica Santana da Silva, Leonardo Pereira Franchi, Tiago Alves Jorge de Souza
Nanotechnology has allowed great changes in chemical, biological and physical properties of metals when compared to their bulk counterparts. Within this context, silver nanoparticles (AgNPs) play a major role due to their unique properties, being widely used in daily products such as fabrics, washing machines, water filters, food and medicine. However, AgNPs can enter cells inducing a "Trojan-horse" type mechanism which potentially leads to cellular autophagy, apoptosis or necrosis. On the other hand, this cytotoxicity mechanism can be optimized to develop drug nanocarriers and anticancer therapies...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29453535/toxicity-of-metal-oxide-nanoparticles
#3
Koyeli Girigoswami
In the recent times, nanomaterials are used in many sectors of science, medicine and industry, without revealing its toxic effects. Thus, it is in urgent need for exploring the toxicity along with the application of such useful nanomaterials. Nanomaterials are categorized with a particle size of 1-100 nm. They have gained increasing attention because of their novel properties, including a large specific surface area and high reaction activity. The various fundamental and practical applications of nanomaterials include drug delivery, cell imaging, and cancer therapy...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452113/technological-innovation-strategies-for-the-specific-treatment-of-chagas-disease-based-on-benznidazole
#4
REVIEW
Leslie Raphael de Moura Ferraz, Alinne Élida Gonçalves Alves, Débora Dolores Souza da Silva Nascimento, Isabela Araújo E Amariz, Aline Silva Ferreira, Salvana Priscylla Manso Costa, Larissa Araújo Rolim, Ádley Antonini Neves de Lima, Pedro José Rolim Neto
Caused by Trypanosoma cruzi, Chagas disease is responsible for public health problems greater in magnitude than those attributed to malaria, schistosomiasis, or leishmaniasis. A factor in the socioeconomic development of poor countries, Chagas disease can cause death due to a high parasitic burden during its acute phase due and irreversible damage in organs such as the heart, esophagus, and colon during its chronic phase, even when the number of parasites is minimal. For treating Chagas disease, benznidazole (BNZ) remains the drug of choice and, in Latin America, the only drug on the market for treating the disease...
February 13, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29451784/alteration-of-crop-yield-and-quality-of-wheat-upon-exposure-to-silver-nanoparticles-in-a-life-cycle-study
#5
Jie Yang, Fuping Jiang, Chuanxin Ma, Yu-Kui Rui, Mengmeng Rui, Adeel Muhammad, Weidong Cao, Baoshan Xing
Due to the rapid development of nanotechnology, metal-based nanoparticles (NPs) are inadvertently released into environment and may pose a potential threat to ecosystem. However, information for food quality and safety in NP treated crops is limited. In the present study, wheat (Triticum aestivum L.) was grown in different concentrations of Ag NP amended soil (20, 200, and 2000 mg•kg-1) for four months. At harvest, physiological parameters, Ag and micronutrients (Fe, Cu, and Zn) content, as well as amino acid and protein contents were measured...
February 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29451128/signal-amplifying-nanoparticle-hydrogel-hybrid-microarray-biosensor-for-metal-enhanced-fluorescence-detection-of-organophosphorus-compounds
#6
Minsu Kim, Kangwon Lee, Ji Eon Kwon, Won Gun Koh
In this study, we developed an enzyme-based miniaturized fluorescence biosensor to detect paraoxon, one of the most well-known neurotoxic organophosphorus compounds (OPs). The biosensor was fabricated with poly(ethylene glycol) (PEG) hydrogel microarrays that entrapped acetylcholinesterase (AChE) and quantum dots (QDs) as fluorescence reporters. Metal-enhanced fluorescence (MEF) was utilized to amplify the fluorescence signal, which was achieved by decorating QDs on the surface of silica-coated silver nanoparticles (Ag@Silica)...
February 16, 2018: Biofabrication
https://www.readbyqxmd.com/read/29448716/templated-growth-of-pd-nanoparticles-using-sputtering-deposition-process-and-its-catalytic-activities
#7
Dario Eberhardt, Pedro Migowski, Sérgio R Teixeira, Adriano F Feil
A simple method based on sputtering deposition of Pd onto mesoporous SiO2 (SBA-15) was employed to produce supported Pd nanoparticles (NPs) that can be used as hydrogenation catalysts. The use of sputtering deposition eliminates contaminants and avoids additional drawbacks of traditional chemical methods applied to prepare heterogeneous supported metal catalysts. A mechanical resonant stirrer was used to revolve the SBA-15 powder and ensure homogeneous distribution of the Pd NPs over the support. The SBA-15 pores act as templates for Pd NPs and drive nanostructure growth...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448639/temperature-dependent-electron-transport-properties-of-gold-nanoparticles-and-composites-scanning-tunneling-spectroscopy-investigations
#8
Sumati Patil, Suwarna Datar, C V Dharmadhikari
Scanning tunneling spectroscopy (STS) is used for investigating variations in electronic properties of gold nanoparticles (AuNPs) and its composite with urethane-methacrylate comb polymer (UMCP) as function of temperature. Films are prepared by drop casting AuNPs and UMCP in desired manner on silicon substrates. Samples are further analyzed for morphology under scanning electron microscopy (SEM) and atomic force microscopy (AFM). STS measurements performed in temperature range of 33 °C to 142 °C show systematic variation in current versus voltage (I-V) curves, exhibiting semiconducting to metallic transition/Schottky behavior for different samples, depending upon preparation method and as function of temperature...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448636/fabrication-of-polydopamine-coating-and-its-application-in-glucose-sensor
#9
Jiali Li, Luting Yan
Polydopamine (PDA) film coatings are multifunctional substances because these coatings can adhere to nearly all known solid materials. The self-polymerization of dopamine in aqueous solution was investigated in this study; PDA films are an effective platform for further functionalization similar to the reduction of silver ions into silver nanoparticles (NPs). The films provide a new method to attach metal NPs on substrates. Through this simple method, glucose sensors based on this kind of Ag NPs/ITO exhibited a detection limit of about 10 μM and presented a good sensitivity enough for real use (3-8 mM)...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448600/effects-of-aging-on-transformation-of-biogenic-magnetite-nanoparticles
#10
Yumi Kim, Yungoo Song, Yul Roh
This study examined the microbial synthesis of magnetite and Pd/Zn-substituted magnetite using metal-reducing bacteria (Clostridium sp.), and the mineralogical characteristics of various types of magnetite formed initially and transformed minerals aged for 5 years. XRD, SXRD, and TEM-EDS analyses were used to characterize the mineralogy, crystal structure, chemistry, shape, and size distribution of the magnetites and transformed minerals. The metal-reducing bacteria reduced akaganeite and Pd/Zn-akaganeite to magnetite and Pd/Zn-substituted magnetite using glucose as an electron donor, respectively...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448579/resin-bonding-to-type-iv-gold-alloy-conditioned-with-a-novel-mercapto-silane-system-effect-of-incorporation-of-a-phosphate-monomer
#11
Sung-Min Kwon, Bong Ki Min, Jun Sik Son, Tae-Yub Kwon
Self-assembled monolayers of thiols have been used to link a range of materials to planar gold surfaces or gold nanoparticles in nanoscience and nanotechnology. Novel mercapto silane systems are a promising alternative to dental noble metal alloys for enhanced resin bonding durability Goldbased alloys for full-cast restorations contain various base metal elements, which may bond to acidic functional monomers chemically, in addition to noble metal elements. This study examined how the additional incorporation of a phosphate monomer (di-2-hydroxyethyl methacryl hydrogenphosphate, DHP) into novel mercapto silane primer systems affected the resin bond strength to a type IV gold alloy pretreated with the primers...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448554/conductive-adhesive-based-on-mussel-inspired-graphene-decoration-with-silver-nanoparticles
#12
Marcello Casa, Maria Sarno, Rosalba Liguori, Claudia Cirillo, Alfredo Rubino, Emanuele Bezzeccheri, Johan Liu, Paolo Ciambelli
Decoration with silver nanoparticles was obtained by coating graphene with a polydopamine layer, able to induce spontaneous metallic nanoparticles formation without any specific chemical interfacial modifier, neither using complex instrumentation. The choice of dopamine was inspired by the composition of adhesive proteins in mussels, related to their robust attach to solid surfaces. The synthesis procedure started from graphite and involved eco-friendly compounds, such as Vitamin C and glucose as reducing agent and water as reaction medium...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448552/plasmonic-screening-effect-of-gold-nanoparticles-array-on-light-absorption-in-poly-3-hexyl-thiophene-thin-film
#13
David Rais, Miroslav Menšík, Bartosz Paruzel, Ivana Šeděnková, Jiří Pfleger
The localized surface plasmon (LSP) photophysical phenomenon occurring in metal nanostructures is often presented as a way to effectively couple light into sub-wavelength-scale photovoltaic devices, which would otherwise suffer from a weak light absorption. The simultaneous complementary effect of localized optical field depletion receives far less attention. We studied a system consisting of a planar gold nanoparticles array (AuNP) deposited at the surface of a semiconducting polymer thin film (P3HT). By comparing the UV-vis spectra of P3HT with and without the AuNP array, we have estimated that the AuNPs screen the optical absorption in the interfacial layer of about 3...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448538/one-step-rf-cvd-method-for-the-synthesis-of-graphene-decorated-with-metal-and-metal-oxide-nanoparticles
#14
S Ramakrishnan, E J Jelmy, R Senthilkumar, Murali Rangarajan, Nikhil K Kothurkar
Bilayer and few layer-graphene (Gr) with noble metal (Ag and Au) and TiO2 nanoparticles were synthesized using atmospheric pressure radio frequency chemical vapor deposition (APRF-CVD). The precursors for the formation of the respective nanoparticles were dissolved in ethanol and injected into the APRF-CVD containing a Cu foil catalyst at 1000 °C. The graphene obtained had a blistered morphology similar to bubble-wrap. The bubble-like protrusions on the graphene sheet were caused by large nanoparticle clusters (~220 nm) formed below the graphene sheets...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448224/a-review-on-electrochemical-detection-of-serotonin-based-on-surface-modified-electrodes
#15
REVIEW
Shikha Sharma, Nidhi Singh, Vartika Tomar, Ramesh Chandra
Serotonin is one of the important neurotransmitters of our body. It's abnormal concentration is associated with multiple disorders and diseases. Sensitive and precise electrochemical determination of serotonin is not possible with bare working electrodes due to various reasons viz. electro-chemical fouling, presence of other biological molecules having similar oxidation potential, and lower concentration of serotonin in biological samples. Surface modification of working electrode is required for fast, precise, selective, and sensitive detection of serotonin...
February 6, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29447433/a-step-into-the-future-applications-of-nanoparticle-enzyme-mimics
#16
Wolfgang Tremel, Karsten Korschelt, Muhammad Nawaz Tahir
We describe elementary concepts, up-to-date developments, and per-spectives of the emerging field of nanoparticle enzyme mimics (so-called "nanozymes") at the interface of chemistry, biology, materials, and nanotechnology. The design and synthesis of functional enzyme mimics is a long-standing goal of biomimetic chemistry. Metal com-plexes, polymers and engineered biomolecules capturing the structure of natural enzymes or their active centers have been made to achieve high rates and enhanced selectivities...
February 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29447049/impact-of-acute-and-subchronic-inhalation-exposure-to-pbo-nanoparticles-on-mice
#17
J Lebedová, Z Nováková, Z Večeřa, M Buchtová, J Dumková, B Dočekal, L Bláhová, P Mikuška, I Míšek, A Hampl, K Hilscherová
Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72 h in acute experiment (4.05 × 10 6 PbO NPs/cm 3 ), and for 1-11 weeks in subchronic experiment (3...
February 15, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29446756/plasmon-enhanced-scattering-and-charge-transfer-in-few-layer-graphene-interacting-with-buried-printed-2d-pattern-of-silver-nanoparticles
#18
Robert Carles, Maxime Bayle, Caroline Bonafos
Hybrid structures combing silver nanoparticles and few-layer graphene have been synthetized by combining low-energy ion beam synthesis and stencil techniques. A single plane of metallic nanoparticles plays the role of an embedded plasmonic enhancer located in dedicated areas at a controlled nanometer distance from deposited graphene layers. Optical imaging, reflectance and Raman scattering mapping are used to measure the enhancement of electronic and vibrational properties of these layers. In particular electronic Raman scattering is shown as notably efficient to analyze the optical transfer of charge carriers between the systems and the presence of intrinsic and extrinsic defects...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29446728/recent-advances-in-the-use-of-metallic-nanoparticles-with-antitumoral-action
#19
Patricia Bento da Silva, Rachel Temperani Amaral Machado, Andressa Maria Pironi, Renata Carolina Alves, Patricia Rocha de Araujo, Amanda Cutrim Dragalzew, Ingrid Dalberto, Marlus Chorilli
The term cancer represents a set of more than 100 diseases that are caused due to an uncontrolled growth of cells; and their subsequent spread to the other tissues and organs of the body by a phenomenon, called 'metastasis'. According to the estimates provided by the World Health Organization (WHO), cancer is expected to account for about 10 million deaths per year by 2020, and 21 million cancer cases, which may lead to 13 million deaths by 2030, making cancer as the cause of highest mortality in contrast to other diseases...
February 13, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29445795/zwitterionic-peptide-capped-gold-nanoparticles-for-colorimetric-detection-of-ni-2
#20
Attasith Parnsubsakul, Sukunya Oaew, Werasak Surareungchai
Zwitterionic nanoparticles are typically utilized as nanoprobes and delivery vehicles in nanomedicine and therapeutics due to their resistance to interferences. Their high stability also shows great potential to be applied in sensing applications. Here, we report a selective, sensitive and rapid colorimetric sensing of nickel ions (Ni 2+ ) using zwitterionic polypeptide, EKEKEKPPPPC (EK) 3 , capped gold nanoparticles (AuNP-(EK) 3 ). By taking advantage of the alternate carboxylic (-COOH)/amine (-NH 2 ) groups, the zwitterionic peptide can function dually by being able to sense metal ions and maintain colloidal stability...
February 15, 2018: Nanoscale
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