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Coronary artery calcium scoring

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https://www.readbyqxmd.com/read/29765227/age-gender-distribution-of-coronary-artery-calcium-score-in-a-black-african-population-in-ghana
#1
George Asafu Adjaye Frimpong, Isaac Kofi Owusu, Ijeoma Chinedum Anyitey-Kokor, Caitlin Selassie Naa Sarku Wiafe-Kwakye, Evans Aboagye, Nana Esi Coleman, Pierre Amankwah, Nakao Kuukua Abaidoo
Background: Distribution of coronary artery calcium (CAC) has been determined in different heterogeneous populations in the Multi-Ethnic Study of Atherosclerosis (MESA). Based on findings showing that geography and culture can influence CAC scoring beyond traditional race groups, we determined the distribution of CAC in a homogenous black African population to provide an initial basis for a larger CAC score study in Africa. Methods and results: This is a preliminary study using computed tomography to determine the CAC scores within a black African population who were referred to our center...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29760599/vascular-erectile-dysfunction-and-subclinical-cardiovascular-disease
#2
Zain Gowani, S M Iftekhar Uddin, Mohammadhassan Mirbolouk, Dawar Ayyaz, Kevin L Billups, Martin Miner, David I Feldman, Michael J Blaha
Purpose of review: We review the recent literature on the hypothesized temporal relationship between subclinical cardiovascular disease (CVD), vascular erectile dysfunction (ED), and clinical CVD. In addition, we combine emerging research with expert consensus guidelines such as The Princeton Consensus III to provide a preventive cardiologist's perspective toward an ideal approach to evaluating and managing CVD and ED risk in patients. Recent findings: Development of ED was found to occur during the progression from subclinical CVD to clinical CVD...
December 2017: Current Sexual Health Reports
https://www.readbyqxmd.com/read/29754662/rationale-and-design-of-a-trial-to-personalize-risk-assessment-in-familial-coronary-artery-disease
#3
Thomas H Marwick, Kristyn Whitmore, Stephen J Nicholls, Tony Stanton, Geoffrey Mitchell, Andrew Tonkin, Christopher Blizzard, Amanda Neil, Catherine Jones, Gerald F Watts
BACKGROUND: The lifetime risk of coronary artery disease (CAD) is doubled in people with a family history of premature disease, yet this risk is not captured in most 5- or 10-year risk assessment algorithms. Coronary artery calcium scoring (CCS) is a marker of subclinical CAD risk, which has been shown in observational studies to provide prognostic information that is incremental to clinical assessment; is relatively inexpensive; and is performed with a small radiation dose. However, the use of CCS in guiding prevention is not strongly supported by guidelines...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29753733/coronary-computed-tomographic-angiography-findings-and-their-therapeutic-implications-in-asymptomatic-patients-with-familial-hypercholesterolemia-lessons-from-the-safeheart-study
#4
Leopoldo Pérez de Isla, Rodrigo Alonso, Ovidio Muñiz-Grijalvo, José Luis Díaz-Díaz, Daniel Zambón, José Pablo Miramontes, Francisco Fuentes, José Juan Gómez de Diego, Aurora González-Estrada, Nelva Mata, Adriana Saltijeral, Manuel Barreiro, Marta Tomás, Raimundo de Andrés, Rosa Argüeso, Maria Pilar Serrano Gotarredona, Silvia Navarro Herrero, Rosario J Perea Palazón, Teresa M de Caralt, Luisa Arrojo Suárez de Centi, Svetlana Zhilina, Simona Espejo Pérez, Teresa Padró, Pedro Mata
BACKGROUND: Familial hypercholesterolemia (FH) confers an increased risk of premature atherosclerotic disease. Coronary computed tomographic angiography (CTA) can assess preclinical coronary atherosclerosis. OBJECTIVES: To describe coronary CTA findings in asymptomatic molecularly defined FH individuals, to identify those factors related to its presence and extension, and to assess the impact of these results in patients' care and estimated risk. METHODS: Four hundred and forty individuals with FH, without clinical cardiovascular disease, were consecutively enrolled and underwent a coronary CTA that was used to analyze coronary atherosclerosis based on coronary calcium score (CCS), sum of stenosis severity, and plaque composition sum (PCS)...
April 17, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29753398/cardiovascular-risk-prediction-in-ckd
#5
REVIEW
Shoshana H Ballew, Kunihiro Matsushita
Cardiovascular disease is an important complication for patients with chronic kidney disease (CKD), warranting accurate risk prediction, but clinical guidelines are inconsistent regarding whether or how to use information on measures of CKD for predicting risk. Recent large meta-analyses have shown that key CKD measures (estimated glomerular filtration rate and albuminuria) improve cardiovascular risk prediction beyond traditional risk factors, especially when albuminuria is added to prediction models. In addition, several recent studies have shown that the use of filtration markers other than serum creatinine, cystatin C, and β2 -microglobulin can improve cardiovascular risk prediction...
May 2018: Seminars in Nephrology
https://www.readbyqxmd.com/read/29751286/the-prevalence-and-correlates-of-subclinical-atherosclerosis-among-adults-with-low-density-lipoprotein-cholesterol-70-mg-dl-the-multi-ethnic-study-of-atherosclerosis-mesa-and-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#6
Mahmoud Al Rifai, Seth S Martin, John W McEvoy, Khurram Nasir, Ron Blankstein, Joseph Yeboah, Michael Miedema, Steven J Shea, Joseph F Polak, Pamela Ouyang, Roger S Blumenthal, Marcio Bittencourt, Isabela Bensenor, Raul D Santos, Bruce B Duncan, Itamar S Santos, Paulo A Lotufo, Michael J Blaha
BACKGROUND AND AIMS: The prevalence and correlates of subclinical atherosclerosis when low-density lipoprotein cholesterol (LDL-C) levels are low remain unclear. Therefore, we examined the association of cardiovascular risk factors and subclinical atherosclerosis among individuals with untreated LDL-C <70 mg/dL. METHODS: We included participants from the Multi-Ethnic Study of Atherosclerosis (MESA) and the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohorts...
April 28, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29751282/sleep-duration-and-subclinical-atherosclerosis-the-aragon-workers-health-study
#7
Elena Blasco-Colmenares, Belén Moreno-Franco, Montserrat León Latre, Eusebio Mur-Vispe, Miguel Pocovi, Estíbaliz Jarauta, Fernando Civeira, Martín Laclaustra, José A Casasnovas, Eliseo Guallar
BACKGROUND AND AIMS: Few studies have evaluated the association of sleep duration with subclinical atherosclerosis, and with heterogeneous findings. We evaluated the association of sleep duration with the presence of coronary, carotid, and femoral subclinical atherosclerosis in healthy middle-age men with low prevalence of clinical comorbidities. METHODS: We performed a cross-sectional analysis of 1968 men, 40-60 years of age, participating in the Aragon Workers' Health Study (AWHS)...
May 3, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29735255/computed-tomography-predictors-of-mortality-stroke-and-conduction-disturbances-in-women-undergoing-tavr-a-sub-analysis-of-the-win-tavi-registry
#8
Marco Spaziano, Alaide Chieffo, Yusuke Watanabe, Jaya Chandrasekhar, Samantha Sartori, Thierry Lefèvre, Anna Sonia Petronio, Patrizia Presbitero, Didier Tchetche, Alessandro Iadanza, Nicholas M Van Mieghem, Julinda Mehilli, Roxana Mehran, Marie-Claude Morice
BACKGROUND: Aortic valve calcification patterns were associated with short- and long-term outcomes in previous small observational datasets of patients undergoing transcatheter aortic valve implantation (TAVI). The specific impact of multi detector-row computed tomography (MDCT) findings on outcomes in women has not been reported. We sought to describe the associations between MDCT characteristics and clinical outcomes in a registry of 547 women undergoing TAVI. METHODS: WIN-TAVI is the first all-female registry to study the safety and effectiveness of TAVI in women (n = 1019)...
April 27, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29734858/current-and-future-applications-of-ct-coronary-calcium-assessment
#9
Christian Tesche, Taylor M Duguay, U Joseph Schoepf, Marly van Assen, Carlo N De Cecco, Moritz H Albrecht, Akos Varga-Szemes, Richard R Bayer, Ullrich Ebersberger, John W Nance, Christian Thilo
Computed tomographic (CT) coronary artery calcium scoring (CAC) has been validated as a well-established screening method for cardiovascular risk stratification and treatment management that is used in addition to traditional risk factors. The purpose of this review is to present an update on current and future applications of CAC. Areas covered: The topic of CAC is summarized from its introduction to current application with focus on the validation and clinical integration including cardiovascular risk prediction and outcome, cost-effectiveness, impact on downstream medical testing, and the technical advances in scanner and software technology that are shaping the future of CAC...
May 8, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29731508/relationship-between-carbohydrate-antigen-125-and-coronary-artery-calcification-in-patients-without-known-coronary-artery-disease
#10
Kun Fu, Hua-Dong Liu, KuerBanJiang MaMuTi, Dong-Nan Hu, Peng Hao
BACKGROUND This study was designed to investigate the association between serum carbohydrate antigen 125 (CA125) and coronary artery calcification (CAC) score in patients without known coronary artery disease. MATERIAL AND METHODS The study groups included 348 consecutive subjects with chest pain but without known coronary artery disease, and who underwent an estimation of CAC score in our hospital. RESULTS The clinical and laboratory characteristics of all subjects are presented according to serum CA125 concentrations tertiles...
May 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29725832/coronary-artery-calcium-assessed-with-calibrated-mass-scoring-in-asymptomatic-individuals-results-from-the-copenhagen-general-population-study
#11
Andreas D Knudsen, Andreas Fuchs, J Tobias Kühl, Ben A Arnold, Børge G Nordestgaard, Lars V Køber, Klaus F Kofoed
BACKGROUND: Coronary artery calcification (CAC) is commonly assessed with Agatston score (AS). A higher sensitivity and precision for the detection of CAC has been demonstrated with calibrated mass score (cMS). We hypothesized that cMS would detect low-level CAC not detectable with AS in a large asymptomatic background population. METHODS: Participants (N = 2985) from the Copenhagen General Population Study were evaluated for CAC using both conventional AS and cMS...
May 3, 2018: European Radiology
https://www.readbyqxmd.com/read/29723329/atherosclerotic-plaque-in-patients-with-zero-calcium-score-at-coronary-computed-tomography-angiography
#12
Fabíola Santos Gabriel, Luiz Flávio Galvão Gonçalves, Enaldo Vieira de Melo, Antônio Carlos Sobral Sousa, Ibraim Masciarelli Francisco Pinto, Sara Melo Macedo Santana, Carlos José Oliveira de Matos, Maria Júlia Silveira Souto, Flávio Mateus do Sacramento Conceição, Joselina Luzia Menezes Oliveira
BACKGROUND: In view of the high mortality for cardiovascular diseases, it has become necessary to stratify the main risk factors and to choose the correct diagnostic modality. Studies have demonstrated that a zero calcium score (CS) is characteristic of a low risk for cardiovascular events. However, the prevalence of individuals with coronary atherosclerotic plaques and zero CS is conflicting in the specialized literature. OBJECTIVE: To evaluate the frequency of patients with coronary atherosclerotic plaques, their degree of obstruction and associated factors in patients with zero CS and indication for coronary computed tomography angiography (CCTA)...
May 3, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29719966/external-validity-of-a-cardiovascular-screening-including-a-coronary-artery-calcium-examination-in-middle-aged-individuals-from-the-general-population
#13
Mette H Grønhøj, Oke Gerke, Hans Mickley, Flemming H Steffensen, Jess Lambrechtsen, Niels Peter R Sand, Lars M Rasmussen, Michael H Olsen, Jesper Hallas, Axel Cp Diederichsen
Background Coronary artery calcium is important in cardiovascular risk stratification, but this knowledge is based on studies with a significant selection bias. This study aims to evaluate the external validity of a screening programme including coronary artery calcium examination, and the association between coronary artery calcium and cardiovascular events. Design Multi-centre population based study. Methods Randomly selected middle-aged men and women ( N = 1751) free of cardiovascular disease were invited to the examination during 2009-2010...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29719035/single-center-retrospective-study-of-risk-factors-and-predictive-value-of-framingham-risk-score-of-patients-with-st-elevation-myocardial-infarction
#14
Sohail Ikram, Ajay Pachika, Henrike Schuster, Aman Ghotra, Laura Dotson, Shoaib Akbar, Abdur Rahman Khan
OBJECTIVES: The objective of this study was to identify risk factors and clinical profile of the patients presenting with ST elevation myocardial infarction (STEMI). We further evaluated the utility of the Framingham Risk Score (FRS) in the accurate identification of these patients if used before their coronary event. METHODS: We evaluated the demographic, clinical, and angiographic characteristics of patients admitted with STEMI. We also calculated cardiovascular event risk using the FRS in a subset of patients without prior known coronary artery disease and diabetes mellitus...
April 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29704026/the-relation-of-low-levels-of-bone-mineral-density-with-coronary-artery-calcium-and-mortality
#15
N Ahmadi, S S Mao, F Hajsadeghi, B Arnold, S Kiramijyan, Y Gao, F Flores, S Azen, M Budoff
Osteoporosis and atherosclerosis are two prevalent major healthcare concerns that frequently coexist. The clinical outcome of 5590 consecutive subjects who underwent coronary artery calcium (CAC) scanning and thoracic bone mineral density (BMD) measurement was assessed. A significant link between low BMD levels and CAC with increased risk of mortality in both genders across ethnicities noted. INTRODUCTION: While a relation of CAC with lower levels of BMD reported previously; it is unclear whether low levels of BMD would be an independent risk factor for CAC and mortality...
April 27, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29703635/differences-in-the-association-of-total-versus-local-coronary-artery-calcium-with-acute-coronary-syndrome-and-culprit-lesions-in-patients-with-acute-chest-pain-the-coronary-calcium-paradox
#16
Stefan B Puchner, Thomas Mayrhofer, Jakob Park, Michael T Lu, Ting Liu, Pal Maurovich-Horvat, Khristine Ghemigian, Daniel O Bittner, Jerome L Fleg, James E Udelson, Quynh A Truong, Udo Hoffmann, Maros Ferencik
BACKGROUND AND AIMS: Total coronary artery calcium (CAC) burden is associated with an increased cardiovascular risk, while local CAC may represent stable plaques. We determined differences in relationship of total CAC with acute coronary syndrome (ACS) and local CAC with culprit lesions in patients with suspected ACS. METHODS: We performed computed tomography (CT) for CAC and CT angiography to assess the presence of significant stenosis and high-risk plaque (positive remodeling, low CT attenuation, napkin-ring sign, spotty calcium) in 37 patients with ACS and 223 controls...
April 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29701806/high-fibroblast-growth-factor-23-is-associated-with-coronary-calcification-in-patients-with-high-adiponectin-analysis-from-the-korean-cohort-study-for-outcome-in-patients-with-chronic-kidney-disease-study
#17
Young Youl Hyun, Hyang Kim, Yun Kyu Oh, Kook-Hwan Oh, Curie Ahn, Su Ah Sung, Kyu Hun Choi, Soo Wan Kim, Kyu-Beck Lee
Background: The association between fibroblast growth factor 23 (FGF23) and coronary artery calcification (CAC) was inconclusive. Recently it was shown that adiponectin modulates renal handling of calcium and phosphorus. We hypothesized that adiponectin plays a role in the effect of FGF23 on CAC and explored whether the association between FGF23 and CAC is modified by serum adiponectin level in chronic kidney disease (CKD) patients. Methods: This cross-sectional study analyzed 1435 predialysis CKD patients from the Korean Cohort Study for Outcome in Patients with CKD cohort...
April 26, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29696430/subtraction-ct-angiography-improves-evaluation-of-significant-coronary-artery-disease-in-patients-with-severe-calcifications-or-stents-the-c-sub-320-multicenter-trial
#18
Andreas Fuchs, J Tobias Kühl, Marcus Y Chen, David Viladés Medel, Xavier Alomar, Sujata M Shanbhag, Steffen Helqvist, Klaus F Kofoed
OBJECTIVES: Diagnostic accuracy of conventional coronary CT angiography (CCTAconv ) may be compromised by blooming artifacts from calcifications or stents. Blooming artifacts may be reduced by subtraction coronary CT angiography (CCTAsub ) in which non-contrast and contrast CT data sets are subtracted digitally. We tested whether CCTAsub in patients with severe coronary calcification or stents reduces the number of false-positive stenosis evaluations compared with CCTAconv . METHODS: In this study, 180 symptomatic patients scheduled for invasive coronary angiography (ICA) were prospectively enrolled and CT scanned (2013-2016) at three international centers...
April 25, 2018: European Radiology
https://www.readbyqxmd.com/read/29688734/assessing-the-relation-of-epicardial-fat-thickness-and-volume-quantified-by-256-slice-computed-tomography-scan-with-coronary-artery-disease-and-cardiovascular-risk-factors
#19
Maryam Mohammadzadeh, Vahid Mohammadzadeh, Madjid Shakiba, Marzieh Motevalli, Azadeh Abedini, Sakineh Kadivar, Pouya Entezari, Ali Mohammadzadeh
BACKGROUND: This study aimed to investigate the association between epicardial adipose tissue (EAT) and coronary artery disease (CAD) as well as cardiovascular risk factors. METHODS: Complete medical records of subjects were reviewed and cardiovascular risk factors were recorded. Epicardial fat volume (EFV) and epicardial fat thickness (EFT) were measured using digital volumetry of acquired images using a 256-slice CT-scanner. Calcium score was measured using Agatston method in non-contrast images...
March 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29680968/an-increased-waist-to-hip-ratio-is-a-key-determinant-of-atherosclerotic-burden-in-overweight-subjects
#20
Roberto Scicali, David Rosenbaum, Antonino Di Pino, Philippe Giral, Philippe Cluzel, Alban Redheuil, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello, Eric Bruckert, Antonio Gallo
AIMS: The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR). METHODS: We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25-29.9 kg/m2 and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease...
April 21, 2018: Acta Diabetologica
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