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https://www.readbyqxmd.com/read/29451900/the-arid1a-p53-and-%C3%A3-catenin-statuses-are-strong-prognosticators-in-clear-cell-and-endometrioid-carcinoma-of-the-ovary-and-the-endometrium
#1
Marlene Heckl, Elisa Schmoeckel, Linda Hertlein, Miriam Rottmann, Udo Jeschke, Doris Mayr
AIM: The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. MATERIALS AND METHODS: 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial carcinomas. RESULTS: Endometrioid ovarian carcinomas showed negative staining for ARID1A (a) and p21 (b), aberrant expression of p53 (c) and p16 (d) and ß-Catenin positive nuclear expression (e) respectively in 19% (a), 100% (b), 28...
2018: PloS One
https://www.readbyqxmd.com/read/29449679/tert-promoter-mutation-in-adult-granulosa-cell-tumor-of-the-ovary
#2
Jessica A Pilsworth, Dawn R Cochrane, Zhouchunyang Xia, Geraldine Aubert, Anniina E M Färkkilä, Hugo M Horlings, Satoshi Yanagida, Winnie Yang, Jamie L P Lim, Yi Kan Wang, Ali Bashashati, Jacqueline Keul, Adele Wong, Kevin Norris, Sara Y Brucker, Florin-Andrei Taran, Bernhard Krämer, Annette Staebler, Esther Oliva, Sohrab P Shah, Stefan Kommoss, Friedrich Kommoss, C Blake Gilks, Duncan M Baird, David G Huntsman
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer cells can attain immortality by activating TERT to maintain telomere length and telomerase activity, which is a crucial step of tumorigenesis. Two somatic mutations in the TERT promoter (C228T; C250T) have been identified as gain-of-function mutations that promote transcriptional activation of TERT in multiple cancers, such as melanoma and glioblastoma. A recent study investigating TERT promoter mutations in ovarian carcinomas found C228T and C250T mutations in 15...
February 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29440297/mi130004-a-novel-antibody-drug-conjugate-combining-trastuzumab-with-a-molecule-of-marine-origin-shows-outstanding-in-vivo-activity-against-her2-expressing-tumors
#3
Pablo M Aviles, Juan Manuel Dominguez, María José Guillén-Navarro, Maria Jose Muñoz-Alonso, Cristina Mateo, Raquel Rodriguez-Acebes, Jose Manuel Molina-Guijarro, Andrés Francesch, Juan Fernando Martínez-Leal, Simon Munt, Carlos M Galmarini, Carmen Cuevas
In the search for novel payloads to design new antibody-drug conjugates (ADCs), marine compounds represent an interesting opportunity given their unique chemical features. PM050489 is a marine compound that binds β-tubulin at a new site and disrupts the microtubule network hence leading to mitotic aberrations and cell death. PM050489 has been conjugated to trastuzumab via Cys residues through a non-cleavable linker and the resulting ADC, named MI130004, has been studied. Analysis of MI130004 delivered data consistent with the presence of two molecules of PM050489 per antibody molecule, likely bound to both sides of the intermolecular disulfide bond connecting the antibody light and heavy chains...
February 13, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29440177/ponatinib-shows-potent-antitumor-activity-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-sccoht-through-multi-kinase-inhibition
#4
Jessica D Lang, William P D Hendricks, Krystal A Orlando, Hongwei Yin, Jeffrey Kiefer, Pilar Ramos, Ritin Sharma, Patrick Pirrotte, Elizabeth A Raupach, Chris Sereduk, Nanyun Tang, Winnie S Liang, Megan Washington, Salvatore J Facista, Victoria L Zismann, Emily M Cousins, Michael B Major, Yemin Wang, Anthony N Karnezis, Aleksandar Sekulic, Ralf Hass, Barbara C Vanderhyden, Praveen Nair, Bernard E Weissman, David G Huntsman, Jeffrey M Trent
PURPOSE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies for SCCOHT. EXPERIMENTAL DESIGN: To identify underlying therapeutic vulnerabilities in SCCOHT, we conducted high-throughput siRNA and drug screens. Complementary proteomics approaches profiled kinases inhibited by ponatinib...
February 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29438162/serum-glucose-and-insulin-and-risk-of-cancers-of-the-breast-endometrium-and-ovary-in-postmenopausal-women
#5
Geoffrey C Kabat, Mimi Y Kim, Dorothy S Lane, Oleg Zaslavsky, Gloria Y F Ho, Juhua Luo, Wanda K Nicholson, Rowan T Chlebowski, Wendy E Barrington, Mara Z Vitolins, Xiaochen Lin, Simin Liu, Thomas E Rohan
Limited evidence suggests that hyperinsulinemia may contribute to the risk of breast, endometrial, and, possibly, ovarian cancer. The aim of this study was to assess the association of serum glucose and insulin with risk of these cancers in postmenopausal women, while taking into account potential confounding and modifying factors. We studied 21 103 women with fasting baseline insulin and glucose measurements in a subsample of the Women's Health Initiative. The subsample was composed of four studies within Women's Health Initiative with different selection and sampling strategies...
February 12, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29437532/using-a-dihydrofolate-reductase-based-strategy-for-producing-the-biosimilar-version-of-pertuzumab-in-cho-s-cells
#6
Amin Ramezani, Abbas Ghaderi
Targeted therapy using monoclonal antibodies (mAbs) against epidermal growth factor receptor-2 (ErbB2) has been utilized for the treatment of breast cancer, recently. Pertuzumab, one of the anti-ErbB2 mAbs, was approved by FDA in 2012 for the treatment of metastatic breast cancer. The aim of this study was to produce biosimilar version of pertuzumab in Chinese hamster ovary (CHO)-S cell line, and compare its ErbB2-binding and biological activities, with commercial drug, Perjeta. To this end, a dihydrofolate reductase (DHFR)-based strategy was used to produce a CHO-S stable cell pool capable of producing high levels of pertuzumab...
February 13, 2018: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
https://www.readbyqxmd.com/read/29435121/lipidomics-reveals-altered-biosynthetic-pathways-of-glycerophospholipids-and-cell-signaling-as-biomarkers-of-the-polycystic-ovary-syndrome
#7
Mariona Jové, Irene Pradas, Alba Naudí, Susana Rovira-Llopis, Celia Bañuls, Milagros Rocha, Manuel Portero-Otin, Antonio Hernández-Mijares, Victor M Victor, Reinald Pamplona
Purpose: In this work, a non-targeted approach was used to unravel changes in the plasma lipidome of PCOS patients. The aim is to offer new insights in PCOS patients strictly selected in order to avoid confounding factors such as dyslipemia, obesity, altered glucose/insulin metabolism, cardiovascular disease, or cancer. Results: Multivariate statistics revealed a specific lipidomic signature for PCOS patients without associated pathologies. This signature implies changes, mainly by down-regulation, in glycerolipid, glycerophospholipid and sphingolipid metabolism suggesting an altered biosynthetic pathway of glycerophospholipids and cell signaling as second messengers in women with PCOS...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434793/development-and-identification-of-set-transgenic-mice
#8
Siliang Xu, Xiaoqiang Liu, Lingling Gao, Boqun Xu, Jianmin Li, Chao Gao, Yugui Cui, Jiayin Liu
As a multifunctional protein involved in numerous biological processes, Set is expressed in several embryonic and adult organs. Furthermore, Set is overexpressed in numerous types of human cancers, including acute myeloid leukemia, breast cancer and pancreatic cancer. The expression of Set in germ cells is involved in gonad development, and the overexpression of Set has been observed in polycystic ovaries. In order to elucidate the physiological and pathological roles of Set, a Set transgenic mouse model was developed, in which the global overexpression of Set in adult tissues could be induced via the Cre/loxP system with the precise deletion of the Stop fragment in double-transgenic hybrids...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29433539/prognostic-impact-of-presumed-breast-or-ovarian-cancer-among-patients-with-unfavorable-subset-cancer-of-unknown-primary-site
#9
Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara, Kenji Tamura
BACKGROUND: The clinical utility and prognostic impact of presumed primary breast or ovarian cancer among patients with an unfavorable subset of cancer of unknown primary site (CUP) remains unclear. We aimed to evaluate the clinical relevance of the presumed primary site of CUP and the clinical outcome of site-specific therapy based on such presumptions. METHODS: Patients referred to our center who were diagnosed with unfavorable-subset CUP and treated between April 2007 and March 2015 were enrolled in this study...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29428311/impact-of-cancer-treatment-on-risk-of-infertility-and-diminished-ovarian-reserve-in-women-with-polycystic-ovary-syndrome
#10
Lisa M Shandley, Amy Fothergill, Jessica B Spencer, Ann C Mertens, Hanh N Cottrell, Penelope P Howards
OBJECTIVE: To compare markers of fertility and ovarian reserve between cancer survivors and cancer-free women with and without polycystic ovary syndrome (PCOS). DESIGN: Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women's Study-a population-based cohort study. SETTING: Not applicable. PATIENT(S): Female cancer survivors (n = 1,090) aged 22-45 years, diagnosed between ages 20 and 35 years, and at least 2 years after diagnosis; 369 participated in a clinic visit...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29423809/identification-of-driver-mutations-in-rare-cancers-the-role-of-smarca4-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-sccoht
#11
Jessica D Lang, William P D Hendricks
Cancer is a complex genetic disease that can arise through the stepwise accumulation of mutations in oncogenes and tumor suppressor genes in a variety of different tissues. While the varied landscapes of mutations driving common cancer types such as lung, breast, and colorectal cancer have been comprehensively charted, the genetic underpinnings of many rare cancers remain poorly defined. Study of rare cancers faces unique methodological challenges, but collaborative enterprises that incorporate next generation sequencing, reach across disciplines (i...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29423568/a-two-phase-approach-to-developing-snap-an-iphone-application-to-support-appointment-scheduling-and-management-for-women-with-a-brca-mutation
#12
Courtney Lynam Scherr, Jessica L Feuston, Dawn M Nixon, Stephanie A Cohen
Professional organizations provide surveillance guidelines for BRCA1 and BRCA2 (BRCA) carriers with intact breasts and/or ovaries to facilitate early cancer detection. However, literature indicates adherence to surveillance guidelines is inconsistent at best. Using the Messaging Model for Health Communication Campaigns framework, we undertook a two-phase formative research approach to develop an intervention to promote adherence to surveillance guidelines. Discussion groups identified preferred intervention format and function in phase I...
February 8, 2018: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/29422962/metformin-and-cancer-an-existing-drug-for-cancer-prevention-and-therapy
#13
Fuming Zi, Huapu Zi, Yi Li, Jingsong He, Qingzhi Shi, Zhen Cai
Metformin is a standard clinical drug used to treat type 2 diabetes mellitus (T2DM) and polycystic ovary syndrome. Recently, epidemiological studies and meta-analyses have revealed that patients with T2DM have a lower incidence of tumor development than healthy controls and that patients diagnosed with cancer have a lower risk of mortality when treated with metformin, demonstrating an association between metformin and tumorigenesis. In vivo and in vitro studies have revealed that metformin has a direct antitumor effect, which may depress tumor proliferation and induce the apoptosis, autophagy and cell cycle arrest of tumor cells...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29422346/bone-loss-in-women-with-brca1-and-brca2-mutations
#14
C Bethan Powell, Amy Alabaster, Nicole Stoller, Mary Anne Armstrong, Chelsea Salyer, Isabella Hamilton, Tina Raine-Bennett
OBJECTIVE: Estimate the prevalence and identify risk factors for bone loss in women with BRCA mutations. METHODS: Women, age 40 and older, with BRCA mutations identified from the Breast Cancer Surveillance database at Kaiser Permanente Northern California were invited to participate and undergo a dual-energy x-ray absorptiometry scan to assess for bone loss (osteopenia or osteoporosis). Multivariable logistic regression analysis was performed to assess clinical factors associated with bone loss...
February 5, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29421840/-fertility-preservation-in-prepubertal-und-pubertal-children-and-adolescents
#15
Nicole Sänger, Andrea Jarisch, Falk Ochsendorf, Thomas Klingebiel, Jana Liebenthron, Sabine Kliesch, Michael von Wolff
BACKGROUND: Due to rising survival rates in cancer and autoimmune diseases fertility preservation before gonadotoxic therapies has become increasingly important. Although fertility can be significantly affected by gonadotoxic therapies, the possibility of fertility preservation during childhood has not been sufficiently considered so far. METHODS: Selective literature research with presentation of fertility preservation methods, their indications, implementations, risks and efficacy...
February 8, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29415641/comparison-of-the-in-vitro-toxicological-activity-of-various-particulate-matter
#16
Hyun-Ki Cho, Chang-Gyun Park, Han-Jae Shin, Ki-Hong Park, Heung-Bin Lim
Ultrafine particles (UFPs, < 2.5 µm) in air pollutants have been identified as a major cause of respiratory diseases, since they can affect the lung alveoli through the bronchus. In particular, if toxicants such as heavy metals and polycyclic aromatic hydrocarbons (PAHs) are present in UFPs, they can cause diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. This study compared in vitro toxicity of various particulate matter including UFPs from combustion particles of diesel (diesel exhaust particles (DEP)), rice straw (RS), pine stem (PS) and coal (CC), and road dust particles from tunnel (TD) and roadside (RD)...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29409506/the-molecular-mechanism-of-ovarian-granulosa-cell-tumors
#17
REVIEW
Jiaheng Li, Riqiang Bao, Shiwei Peng, Chunping Zhang
Over these years, more and more sex cord-stromal tumors have been reported. Granulosa cell tumor (GCT) is a rare tumor in ovaries, accounts for 2% to 5% of ovarian cancers. The main different feature of GCTs from other ovarian cancers is that GCTs can lead to abnormally secreted hormones (estrogen, inhibin and Müllerian inhibiting substance). The GCT is divided into two categories according to the age of patients, namely AGCT (adult granulosa cell tumor) and JGCT (Juvenile granulosa cell tumor). AGCT patients accounts for 95%...
February 6, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29399186/detachment-from-the-primary-site-and-suspension-in-ascites-as-the-initial-step-in-metabolic-reprogramming-and-metastasis-to-the-omentum-in-ovarian-cancer
#18
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Atsushi Komatsu, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Cancer cell metabolism is currently considered to be context dependent, and metabolic reprogramming is being widely investigated. It is known that ovarian cancer often metastasizes to the omentum. Given that the omentum itself contains a high concentration of adipocytes, ovarian cancer is thought to be a good model for research into metabolic reprogramming (particularly the shift to lipid metabolism). The present study investigated the switch to lipid metabolism in the metabolic reprogramming of ovarian cancer cells...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29395311/processing-of-fallopian-tube-ovary-and-endometrial-surgical-pathology-specimens-a-survey-of-u-s-laboratory-practices
#19
Goli Samimi, Britton Trabert, Máire A Duggan, Jennifer L Robinson, Kisha I Coa, Elizabeth Waibel, Edna Garcia, Lori M Minasian, Mark E Sherman
OBJECTIVE: Many high-grade serous carcinomas initiate in fallopian tubes as serous tubal intraepithelial carcinoma (STIC), a microscopic lesion identified with specimen processing according to the Sectioning and Extensive Examination of the Fimbria protocol (SEE-Fim). Given that the tubal origin of these cancers was recently recognized, we conducted a survey of pathology practices to assess processing protocols that are applied to gynecologic surgical pathology specimens in clinical contexts in which finding STIC might have different implications...
January 25, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29395269/global-surveillance-of-trends-in-cancer-survival-2000-14-concord-3-analysis-of-individual-records-for-37%C3%A2-513%C3%A2-025-patients-diagnosed-with-one-of-18-cancers-from-322-population-based-registries-in-71-countries
#20
Claudia Allemani, Tomohiro Matsuda, Veronica Di Carlo, Rhea Harewood, Melissa Matz, Maja Nikšić, Audrey Bonaventure, Mikhail Valkov, Christopher J Johnson, Jacques Estève, Olufemi J Ogunbiyi, Gulnar Azevedo E Silva, Wan-Qing Chen, Sultan Eser, Gerda Engholm, Charles A Stiller, Alain Monnereau, Ryan R Woods, Otto Visser, Gek Hsiang Lim, Joanne Aitken, Hannah K Weir, Michel P Coleman
BACKGROUND: In 2015, the second cycle of the CONCORD programme established global surveillance of cancer survival as a metric of the effectiveness of health systems and to inform global policy on cancer control. CONCORD-3 updates the worldwide surveillance of cancer survival to 2014. METHODS: CONCORD-3 includes individual records for 37·5 million patients diagnosed with cancer during the 15-year period 2000-14. Data were provided by 322 population-based cancer registries in 71 countries and territories, 47 of which provided data with 100% population coverage...
January 30, 2018: Lancet
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