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https://www.readbyqxmd.com/read/29900650/surgery-is-critical-to-a-multidisciplinary-approach-to-ovarian-cancer
#1
Linda R Duska
Surgery plays a critical role in all aspects of the management of ovarian cancer: from comprehensive staging of disease apparently confined to one ovary; to complete removal of advanced disease at the time of presentation; to appropriate surgical management of disease recurrence. As such, the surgeon plays an essential role in the management of this disease throughout its course. Appropriate and aggressive surgical management has been demonstrated in countless publications to improve overall survival from this disease...
June 14, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29899826/synthetic-lethality-in-ccne1-amplified-high-grade-serous-ovarian-cancer-through-combined-inhibition-of-polo-like-kinase-1-and-microtubule-dynamics
#2
Sabrina Noack, Monika Raab, Yves Matthess, Mourad Sanhaji, Andrea Krämer, Balázs Győrffy, Lars Kaderali, Ahmed El-Balat, Sven Becker, Klaus Strebhardt
The taxanes are effective microtubule-stabilizing chemotherapy drugs that inhibit mitosis, induce apoptosis, and produce regression in a fraction of cancers that arise at many sites including the ovary. Novel therapeutic targets that augment taxane effects are needed to improve clinical chemotherapy response in CCNE1 -amplified high grade serous ovarian cancer (HGSOC) cells. In this study, we conducted an siRNA-based kinome screen to identify modulators of mitotic progression in CCNE1 -amplified HGSOC cells that may influence clinical paclitaxel response...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29897392/representation-of-obese-participants-in-obesity-related-cancer-randomized-trials
#3
E Pestine, A Stokes, L Trinquart
Background: Obesity is a risk factor for numerous cancer types, and may influence cancer treatment outcomes. Underrepresentation of obese patients in obesity-related cancer randomized controlled trials (RCTs) may affect generalizability of results. We aimed to assess the reporting of information about eligibility and enrollment of obese participants in obesity-related cancer RCTs. Methods: We conducted a systematic review of RCTs of 10 obesity-related cancer types (esophagus, colon/rectum, liver, gallbladder, pancreas, postmenopausal breast, endometrium, ovary, kidney, and thyroid cancer)...
April 20, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29894801/effects-of-cigarette-smoke-extracts-on-apoptosis-and-oxidative-stress-in-two-models-of-ovarian-cancer-in-vitro
#4
Cho-Won Kim, Ryeo-Eun Go, Kyung-A Hwang, Ok-Nam Bae, Kyuhong Lee, Kyung-Chul Choi
Cigarette smoke contains thousands of harmful components, many of which exert toxic effects on reproductive organs, including the ovaries, and their development. In this study, we investigated the effects of cigarette smoke extract (CSE) on cell proliferation, apoptosis and oxidative stress in the SKOV3 and OVCAR3 ovarian cancer cell lines. A water soluble tetrazolium (WST) assay revealed that the cell proliferation of both ovarian cells was significantly inhibited by three types of CSE in a concentration-dependent manner...
June 9, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29892687/clonal-lineage-of-high-grade-serous-ovarian-cancer-in-a-patient-with-neurofibromatosis-type-1
#5
Eric J Norris, Wendell D Jones, Marius D Surleac, Andrei J Petrescu, Darla Destephanis, Qing Zhang, Issam Hamadeh, Jeffrey S Kneisl, Chad A Livasy, Ram N Ganapathi, David L Tait, Mahrukh K Ganapathi
Neurofibromatosis type 1 (NF1) is caused by mutations in the NF1 gene encoding neurofibromin, which negatively regulates Ras signaling. NF1 patients have an increased risk of developing early onset breast cancer, however, the association between NF1 and high grade serous ovarian cancer (HGSOC) is unclear. Since most NF1-related tumors exhibit early biallelic inactivation of NF1 , we evaluated the evolution of genetic alterations in HGSOC in an NF1 patient. Somatic variation analysis of whole exome sequencing of tumor samples from both ovaries and a peritoneal metastasis showed a clonal lineage originating from an ancestral clone within the left adnexa, which exhibited copy number (CN) loss of heterozygosity (LOH) in the region of chromosome 17 containing TP53, NF1 , and BRC A1 and mutation of the other TP53 allele...
February 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29890352/minimally-invasive-surgery-staging-of-apparent-stage-i-malignant-ovarian-germ-cell-tumors-prevalence-and-outcomes
#6
Dimitrios Nasioudis, Evelyn Minis, Eloise Chapman-Davis, Melissa K Frey, Thomas A Caputo, Steven S Witkin, Kevin Holcomb
STUDY OBJECTIVE: Evaluate the prevalence, trends and outcomes of minimally invasive surgical staging (MIS) of malignant ovarian germ cell tumors (MOGCTs) apparently confined to the ovary. DESIGN: Retrospective cohort study (Canadian Task Force classification II-2) SETTING: Participating hospitals in the National Cancer Data Base PATIENTS: Women diagnosed between 2010-2014 with a MOGCT apparently confined to the ovary with information on the planned surgical approach...
June 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29887343/incidence-of-cancer-other-than-gastric-cancer-in-pernicious-anaemia-a-systematic-review-with-meta-analysis
#7
REVIEW
Edith Lahner, Marina Capasso, Marilia Carabotti, Bruno Annibale
BACKGROUND: Pernicious anaemia (PA) is associated with increased gastric cancer risk, but the evidence is conflicting regarding the associated risk of other cancers. AIM: To systematically determine the incidence rates of gastro-intestinal cancers other than gastric cancers (GI-other-than-GC) and non-gastrointestinal cancers (non-GIC) in PA adults, globally and per tumour site, and the risk associated with PA for GI-other than GC and non-GIC. METHODS: Studies of PA patients reporting the incidence of GI-other-than-GCs and non-GICs were identified with MEDLINE (PubMed)-EMBASE (from first date available to April 2017)...
May 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29879027/primary-ovarian-small-cell-carcinoma-of-pulmonary-type-with-coexisting-endometrial-carcinoma-in-a-breast-cancer-patient-receiving-tamoxifen-a-case-report-and-literature-review
#8
Lei Yin, Jianning Li, Yunhai Wei, Dejian Ma, Yamei Sun, Yanlai Sun
RATIONALE: Small cell carcinoma of the ovary (SCCO) is a rare and aggressive extra-pulmonary variant of small cell tumors of uncertain histogenesis. The pathogenesis and optimal treatment of SCCO is unclear. We present a very rare case of a synchronous primary ovarian small cell carcinoma and endometrioid adenocarcinoma of the uterus in a patient after 2 years of tamoxifen treatment for breast cancer. This is the first such report in the English literature. PATIENT CONCERNS: A 46-year-old woman had a history of left breast cancer that was treated with a simple mastectomy and sentinel lymph node biopsy in 2013...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29872358/clean-colorectum-at-diagnostic-colonoscopy-subsequent-detection-of-extracolonic-malignancies-by-plasma-protein-biomarkers
#9
Michael Wilhelmsen, Ib J Christensen, Lars N Jørgensen, Mogens R Madsen, Jesper Vilandt, Thore Hillig, Michael Klærke, Knud T Nielsen, Søren Laurberg, Susan Gawel, Xiaoping Yang, Gerard Davis, Anne Meike Heijboer, Frans Martens, Hans J Nielsen
Introduction: Most of the subjects undergoing diagnostic colonoscopy do not have neoplastic bowel lesions. Potentially, some of the symptoms may therefore be caused by extracolonic malignancy, and subjects with persisting symptoms may need subsequent examinations. Blood-based, cancer-associated biomarkers may aid in directing the examinations for other specific malignant diseases. Methods: EDTA plasma samples available from a previous prospective study of subjects undergoing diagnostic colonoscopy were used for analysis of 18 protein biomarkers...
2018: Biomarkers in Cancer
https://www.readbyqxmd.com/read/29872347/lifetime-risks-loss-of-life-expectancy-and-health-care-expenditures-for-19-types-of-cancer-in-taiwan
#10
Tzu-Yi Wu, Chia-Hua Chung, Chia-Ni Lin, Jing-Shiang Hwang, Jung-Der Wang
Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs) after diagnosis, expected years of life lost (EYLL), and lifetime health care expenditures for 19 major cancers in Taiwan. Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. They were linked to the National Mortality Registry (1998-2014) and National Health Insurance reimbursement database (1998-2013) for survival and health care costs...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29870337/identifying-functional-modules-in-co-regulatory-networks-through-overlapping-spectral-clustering
#11
Jiawei Luo, Ying Yin, Chu Pan, Gen Xiang, Nguyen Hoang Tu
At the co-regulatory network level, functional modules comprising microRNAs (miRNAs), transcription factors (TFs), and common target genes (mRNAs) are found to be widespread in diverse organisms from bacteria to human, suggesting that co-regulatory functional modules (CRMs) serve as basic building blocks of transcription networks. Identification of CRMs would contribute to explore the miRNAs and TFs regulatory mechanism to specific cancer. However, few studies considered the functional modules which contain TFs and overlapping parts now...
April 2018: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29866752/risk-of-ischemic-and-hemorrhagic-strokes-in-occult-and-manifest-cancers
#12
Klaus Kaae Andersen, Tom Skyhøj Olsen
BACKGROUND AND PURPOSE: Manifest cancer is associated with increased risk of stroke. The risk of stroke in people with occult cancer in comparison to the risk in the background population without cancer has not been investigated. Smoking is a risk factor for both cancer and stroke, but the role of smoking for the risk of stroke in cancer has not been investigated. METHODS: We identified all incident cases of cancer in Denmark 2003 to 2012 (n=264.376) from the Danish Cancer Registry...
June 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29866643/assessing-statewide-all-cause-future-one-year-mortality-prospective-study-with-implications-for-quality-of-life-resource-utilization-and-medical-futility
#13
Yanting Guo, Gang Zheng, Tianyun Fu, Shiying Hao, Chengyin Ye, Le Zheng, Modi Liu, Minjie Xia, Bo Jin, Chunqing Zhu, Oliver Wang, Qian Wu, Devore S Culver, Shaun T Alfreds, Frank Stearns, Laura Kanov, Ajay Bhatia, Karl G Sylvester, Eric Widen, Doff B McElhinney, Xuefeng Bruce Ling
BACKGROUND: For many elderly patients, a disproportionate amount of health care resources and expenditures is spent during the last year of life, despite the discomfort and reduced quality of life associated with many aggressive medical approaches. However, few prognostic tools have focused on predicting all-cause 1-year mortality among elderly patients at a statewide level, an issue that has implications for improving quality of life while distributing scarce resources fairly. OBJECTIVE: Using data from a statewide elderly population (aged ≥65 years), we sought to prospectively validate an algorithm to identify patients at risk for dying in the next year for the purpose of minimizing decision uncertainty, improving quality of life, and reducing futile treatment...
June 4, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29857911/exercise-and-chemotherapy-induced-amenorrhea
#14
Katlynn M Mathis, Kathleen M Sturgeon, Renate M Winkels, Joachim Wiskemann, Nancy I Williams, Kathryn Schmitz
Chemotherapy-induced amenorrhea (CIA) is the temporary or permanent loss of menses experienced by premenopausal women undergoing chemotherapy treatment for cancer. Two possible mechanisms through which chemotherapy induces CIA have been identified: systemic endothelial dysfunction, resulting in decreased blood flow to the ovaries, and increased oxidative stress within the ovaries, both of which are proposed to lead to apoptosis of follicles. Endothelial dysfunction in ovarian arteries in women undergoing or who have undergone chemotherapy treatment is characterized by prothrombotic changes and thickening of the vascular wall...
July 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29849110/identification-of-a-peptide-for-folate-receptor-alpha-by-phage-display-and-its-tumor-targeting-activity-in-ovary-cancer-xenograft
#15
Lijun Xing, Yifeng Xu, Keyong Sun, Hong Wang, Fengguo Zhang, Zhengpin Zhou, Juan Zhang, Fang Zhang, Bilgen Caliskan, Zheng Qiu, Min Wang
The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRα expressing cells by cell ELISA and flow cytometry. Tumor targeting ability of C7 was proved in vivo by both phage homing experiment and fluorescence imaging...
May 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29848369/superficially-invasive-cervical-squamous-cell-carcinoma-metastatic-to-ovarian-endometriotic-cyst-wall-a-case-report-and-brief-review-of-the-literature
#16
Minfen Zhang, Elena Lucas, Hanzhen Xiong, Shaoyan Liu, Kyle Molberg, Qingping Jiang, Wenxin Zheng
BACKGROUND: Although cases of cervical squamous cell carcinoma metastatic to the ovary have been previously documented, we report the first case of superficially invasive squamous cell carcinoma metastatic to the ovary. CASE PRESENTATION: A 45-year-old woman with a two-year history of ovarian endometriosis confirmed by ultrasound underwent oophorectomy. On microscopic examination, a focus of malignant stratified epithelium, initially interpreted as transitional cell carcinoma, was identified within the endometriotic cyst wall...
May 30, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29843147/roles-and-mechanisms-of-human-cathelicidin-ll-37-in-cancer
#17
Xi Chen, Xianqiong Zou, Guangying Qi, Ying Tang, Yong Guo, Jia Si, Lihua Liang
LL-37, the C-terminal peptide of human cathelicidin antimicrobial peptide (CAMP, hCAP18), reportedly increases resistance to microbial invasion and exerts important physiological functions in chemotaxis, promotion of wound closure, and angiogenesis. Accumulating evidence indicates that LL-37 also plays a significant role in human cancer. LL-37 induces tumorigenic effects in cancers of the ovary, lung, breast, prostate, pancreas, as well as in malignant melanoma and skin squamous cell carcinoma. In contrast, LL-37 displays an anti-cancer effect in colon cancer, gastric cancer, hematologic malignancy and oral squamous cell carcinoma...
May 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29806794/the-history-of-natural-progesterone-the-never-ending-story
#18
P Piette
The term progesterone should only be used for the natural hormone produced by the ovaries or included in a registered drug. The modern history of progesterone begins with the first book-length description of the female reproductive system including the corpus luteum and later with the Nobel Prize winner, Adolf Butenandt who took a crucial step when he succeeded in converting pregnanediol into a chemically pure form of progesterone, the corpus luteum hormone. The deficient production of progesterone was shown first to be the cause of the luteal-phase deficiency responsible for infertility and early pregnancy loss due to inadequate secretory transformation of the endometrium...
May 28, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29795269/loss-of-puma-protects-the-ovarian-reserve-during-dna-damaging-chemotherapy-and-preserves-fertility
#19
Quynh-Nhu Nguyen, Nadeen Zerafa, Seng H Liew, F Hamish Morgan, Andreas Strasser, Clare L Scott, Jock K Findlay, Martha Hickey, Karla J Hutt
Female gametes are stored in the ovary in structures called primordial follicles, the supply of which is non-renewable. It is well established that DNA-damaging cancer treatments can deplete the ovarian reserve of primordial follicles, causing premature ovarian failure and infertility. The precise mechanisms underlying this chemotherapy-driven follicle loss are unclear, and this has limited the development of targeted ovarian-protective agents. To address this fundamental knowledge gap, we used gene deletion mouse models to examine the role of the DNA damage-induced pro-apoptotic protein, PUMA, and its transcriptional activator TAp63, in primordial follicle depletion caused by treatment with cyclophosphamide or cisplatin...
May 23, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29794794/clear-cell-carcinoma-of-the-ovary-clinicopathologic-features-and-outcomes-in-a-chinese-cohort
#20
Haosha Tang, Yan Liu, Xiao Wang, Luyao Guan, Weiming Chen, Hongyuan Jiang, Yuan Lu
This retrospective analysis aimed to clarify the clinical and pathologic features of ovarian clear cell carcinoma (OCCC), and to determine the factors predictive of survival.Data waereextracted from OCCC patients who underwent primary surgery followed by adjuvant chemotherapy in Obstetrics & Gynecology Hospital of Fudan University between January2007 and December 2014. Kaplan-Meier survival estimates and Cox proportional hazards model were used for survival analyses.Of 130 patients (mean age = 56.2 years), 66...
May 2018: Medicine (Baltimore)
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