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https://www.readbyqxmd.com/read/29054323/human-kidney-stone-matrix-latent-potential-to-restrain-com-induced-cytotoxicity-and-inflammatory-response
#1
Shifa Narula, Simran Tandon, Prakash Baligar, Shrawan Kumar Singh, Chanderdeep Tandon
Kidney stone disease is a multi-factorial disorder resulting from the interplay of various risk factors including lifestyle, environment and genetics along with metabolic activities inside the body. However, it is difficult to determine how these factors converge to promote stone disease. Extensive investigations of kidney stone composition at the molecular level have been carried out however; its impact on the complex mechanism of stone formation is still obscure. Hence, an in vitro study was designed to investigate the attenuation of calcium oxalate toxicity by human kidney stone matrix proteins on NRK-52E cells using flowcytometry, Western blotting, RT-PCR and immunofluorescence assays...
October 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29053546/histopathology-of-calciphylaxis-cohort-study-with-clinical-correlations
#2
Tiffany Y Chen, Julia S Lehman, Lawrence E Gibson, Christine M Lohse, Rokea A El-Azhary
Calciphylaxis is a rare, painful, and life-threatening condition with a high mortality rate. Although the etiology of calciphylaxis is not well understood, it has been proposed that calcium deposition within and around subcutaneous vessels restricts blood flow chronically, thereby predisposing the patient to acute pannicular and dermal thrombosis. Given increasing recognition of the role of hypercoagulability in calciphylaxis, this retrospective cohort study sought to evaluate the presence of thromboses and dermal angioplasia in calciphylaxis...
November 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29053424/l-carnitine-and-potential-protective-effects-against%C3%A2-ischemia-reperfusion-injury-in-noncardiac-organs-from-experimental-data-to-potential-clinical-applications
#3
Azadeh Moghaddas, Simin Dashti-Khavidaki
The mechanism of ischemia-reperfusion (I/R) injury is complex and multifactorial. In this condition, systemic event results in morbidity and mortality in several pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, and circulatory arrest. Hypoxia over ischemia phase leads to energy imbalance and changes of cellular homeostasis and functional or structural alterations. In addition, during the reperfusion period, some events, including calcium influx, release of intracellular enzymes, and cell membrane integrity breakdown, cause cell death...
October 20, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29051055/skeletal-impairment-in-pierson-syndrome-is-there-a-role-for-laminin%C3%AE-2-in-bone-physiology
#4
Camille Beaufils, Delphine Farlay, Irma Machuca-Gayet, Alice Fassier, Martin Zenker, Caroline Freychet, Edith Bonnelye, Aurélia Bertholet-Thomas, Bruno Ranchin, Justine Bacchetta
INTRODUCTION: Pierson syndrome is caused by a mutation of LAMB2, encoding for laminin β2. Clinical phenotype is variable but usually associates congenital nephrotic syndrome (CNS) and ocular abnormalities. Neuromuscular impairment has also been described. METHODS: We report on a 15-year old girl, suffering from Pierson Syndrome, who developed severe bone deformations during puberty. This patient initially displayed CNS and microcoria, leading to the clinical diagnosis of Pierson syndrome...
October 16, 2017: Bone
https://www.readbyqxmd.com/read/29050225/hcarg-commd5-inhibits-erbb-receptor-driven-renal-cell-carcinoma
#5
Hiroyuki Matsuda, Carole G Campion, Kyoko Fujiwara, Jin Ikeda, Suzanne Cossette, Thomas Verissimo, Maiko Ogasawara, Louis Gaboury, Kosuke Saito, Kenya Yamaguchi, Satoru Takahashi, Morito Endo, Noboru Fukuda, Masayoshi Soma, Pavel Hamet, Johanne Tremblay
Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) is highly expressed in renal proximal tubules, where it contributes to the control of cell proliferation and differentiation. HCaRG accelerates tubular repair by facilitating re-differentiation of injured proximal tubular epithelial cells, thus improving mouse survival after acute kidney injury. Sustained hyper-proliferation and de-differentiation are important hallmarks of tumor progression. Here, we demonstrate that cancer cells overexpressing HCaRG maintain a more differentiated phenotype, while several of them undergo autophagic cell death...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29044732/fresh-tissue-parathyroid-allotransplantation-with-short-term-immunosuppression-1-year-follow-up
#6
Emrah Yucesan, Beyza Goncu, Harun Basoglu, Nur Ozten Kandas, Yeliz Emine Ersoy, Fahri Akbas, Erhan Aysan
BACKGROUND: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear. METHOD: We performed PA from two donors to two recipients. Both recipients were 39-year-old females. Donors were a 32-year-old female and a 36-year-old male, who both have chronic kidney disease. Routine tests, viral markers, and cross-matches were analyzed individually...
August 12, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29043081/effects-of-phospho-and-calciotropic-hormones-on-electrolyte-transport-in-the-proximal-tubule
#7
REVIEW
Justin J Lee, Allein Plain, Megan R Beggs, Henrik Dimke, R Todd Alexander
Calcium and phosphate are critical for a myriad of physiological and cellular processes within the organism. Consequently, plasma levels of calcium and phosphate are tightly regulated. This occurs through the combined effects of the phospho- and calciotropic hormones, parathyroid hormone (PTH), active vitamin D 3, and fibroblast growth factor 23 (FGF23). The organs central to this are the kidneys, intestine, and bone. In the kidney, the proximal tubule reabsorbs the majority of filtered calcium and phosphate, which amounts to more than 60% and 90%, respectively...
2017: F1000Research
https://www.readbyqxmd.com/read/29042438/the-serum-protein-renalase-reduces-injury-in-experimental-pancreatitis
#8
Thomas R Kolodecik, Anamika M Reed, Kimie Date, Christine Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V Desir, Fred S Gorelick
Acute pancreatitis is a disease associated with inflammation and tissue damage. One protein that protects against acute injury, including ischemic injury to both the kidney and heart, renalase, which is secreted into the blood by the kidney and other tissues. However, whether renalase reduces acute injury associated with pancreatitis is unknown. Here, we used both in vitro and in vivo murine models of acute pancreatitis to study renalase effects on this condition. In isolated pancreatic lobules, pretreatment with recombinant human renalase (rRNLS) blocked zymogen activation caused by cerulein, carbachol, and a bile acid...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29039485/calcium-dobesilate-may-alleviate-diabetes%C3%A2-induced-endothelial-dysfunction-and-inflammation
#9
Yijun Zhou, Jiangzi Yuan, Chaojun Qi, Xinghua Shao, Shan Mou, Zhaohui Ni
Diabetic kidney disease (DKD) is a leading cause of end‑stage renal disease. However, the pathogenesis of DKD remains unclear, and no effective treatments for the disease are available. Thus, there is an urgent need to elucidate the pathogenic mechanisms of DKD and to develop more effective therapies for this disease. Human umbilical vein endothelial cells (HUVECs) were cultured using different D‑glucose concentrations to determine the effect of high glucose (HG) on the cells. Alternatively, HUVECs were incubated with 100 µmol/l calcium dobesilate (CaD) to detect its effects...
October 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29038882/etelcalcetide-a-novel-calcimimetic-prevents-vascular-calcification-in-a-rat-model-of-renal-insufficiency-with-secondary-hyperparathyroidism
#10
Longchuan Yu, James E Tomlinson, Shawn T Alexander, Kelly Hensley, Chun-Ya Han, Denise Dwyer, Marina Stolina, Charles Dean, William G Goodman, William G Richards, Xiaodong Li
Etelcalcetide, a novel peptide agonist of the calcium-sensing receptor, prevents vascular calcification in a rat model of renal insufficiency with secondary hyperparathyroidism. Vascular calcification occurs frequently in patients with chronic kidney disease (CKD) and is a consequence of impaired mineral homeostasis and secondary hyperparathyroidism (SHPT). Etelcalcetide substantially lowers parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF23) levels in SHPT patients on hemodialysis. This study compared the effects of etelcalcetide and paricalcitol on vascular calcification in rats with adenine-induced CKD and SHPT...
October 16, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29038837/reduced-kidney-function-is-associated-with-bmd-bone-loss-and-markers-of-mineral-homeostasis-in-older-women-a-10-year-longitudinal-study
#11
L Malmgren, F McGuigan, A Christensson, K E Akesson
Kidney function decreases with age; however, the long-term influence on bone density (BMD) in older women already at risk of osteoporosis is unknown. We followed kidney function and bone loss for 10 years. Declining kidney function was adversely associated with bone loss and mineral homeostasis in old women, though it attenuated with advanced aging. INTRODUCTION: Existing studies do not fully address the relationship between kidney function and bone metabolism with advanced aging in Caucasian women...
October 16, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29038707/prevalence-of-idiopathic-hypercalciuria-in-children-with-urinary-system-related-symptoms-attending-a-pediatric-hospital-in-bandar-abbas-in-2014
#12
Maryam Esteghamati, Kambiz Ghasemi, Marie Nami
BACKGROUND: Idiopathic hypercalciuria is a group of diseases which can be manifested with urinary symptoms. Its importance is due to high prevalence, recurrent infections, and stone formations which are often asymptomatic. OBJECTIVE: The objective of this study was to determine the prevalence of idiopathic hypercalciuria in children with urinary system related symptoms in Bandar Abbas in 2014. METHODS: This descriptive cross-sectional study was done in 2014 in a children's hospital in Bandar Abbas (southern Iran) on 321 children who were between 2 months to 14 years old...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29038394/factors-associated-with-lumbar-and-femoral-bone-mineral-density-in-kidney-transplants-candidates
#13
Mohammad Aghighi, Mitra Mahdavi Mazdeh, Mohsen Nafar, Vahid Rakhshan
INTRODUCTION: Data on risk factors associated with low bone mineral density are limited in patients with end-stage renal disease. This study evaluated the factors deemed associated with lumbar and femoral Z and T scores. MATERIALS AND METHODS: Clinical and demographic data of 98 patients waiting for kidney transplantation were collected, as well as lumbar and femoral bone densitometries, before transplantation. Osteoporosis and osteopenia and factors associated with bone mineral density were assessed...
October 2017: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/29038362/cdc42-activation-couples-fluid-shear-stress-to-apical-endocytosis-in-proximal-tubule-cells
#14
Sohinee Bhattacharyya, Frédéric G Jean-Alphonse, Venkatesan Raghavan, Jennifer C McGarvey, Youssef Rbaibi, Jean-Pierre Vilardaga, Marcelo D Carattino, Ora A Weisz
Cells lining the kidney proximal tubule (PT) respond to acute changes in glomerular filtration rate and the accompanying fluid shear stress (FSS) to regulate reabsorption of ions, glucose, and other filtered molecules and maintain glomerulotubular balance. Recently, we discovered that exposure of PT cells to FSS also stimulates an increase in apical endocytic capacity (Raghavan et al. PNAS, 111:8506-8511, 2014). We found that FSS triggered an increase in intracellular Ca(2+) concentration ([Ca(2+)]i) that required release of extracellular ATP and the presence of primary cilia...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29037849/letrozole-induced-low-estrogen-levels-affected-the-expressions-of-duodenal-and-renal-calcium-processing-gene-in-laying-hens
#15
REVIEW
Qiao Li, Xingkai Zhao, Shujie Wang, Zhenlei Zhou
Estrogen regulates the calcium homeostasis in hens, but the mechanisms involved are still unclear fully. In this study, we investigated whether letrozole (LZ) induced low estrogen levels affected the calcium absorption and transport in layers. In the duodenum, we observed a significant decrease of mRNA expressions of Calbindin-28k (CaBP-28k) and plasma membrane Ca(2+)-ATPase (PMCA 1b) while CaBP-28k protein expression was declined in birds with LZ treatment, and the mRNA levels of duodenal transient receptor potential vanilloid 6 (TRPV6) and Na(+)/Ca(2+) exchanger 1 (NCX1) were not affected...
October 13, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29035195/effects-of-fasting-during-the-month-of-ramadan-on-renal-function-in-patients-with-autosomal-dominant-polycystic-kidney-disease%C3%A2
#16
Iskender Ekinci, Reha Erkoc, Meltem Gursu, Elif Ece Dogan, Elif Kilic, Egemen Cebeci, Savas Ozturk, Rumeyza Kazancioglu
BACKGROUND: In this study, we aimed to examine the impact of fasting during the month of Ramadan on autosomal dominant polycystic kidney disease (-ADPKD) patients with normal to near-normal glomerular filtration rate (GFR). MATERIALS AND METHODS: This was a prospective observational study of patients with ADPKD, the majority of whom had normal or near-normal GFR. Patients were divided into two groups: the fasting group (FG) and the nonfasting group (NFG). Assessments in the NFG were performed 1 week before and 1 month after Ramadan, while FG patients were assessed on the last day of fasting in addition to the abovementioned visits...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29034196/protective-effect-of-ethyl-acetate-fraction-of-biophytum-sensitivum-extract-against-sodium-oxalate-induced-urolithiasis-in-rats
#17
Anil T Pawar, Niraj S Vyawahare
The methanolic whole plant extract of Biophytum sensitivum (gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29032812/matrix-vesicles-induce-calcification-of-recipient-vascular-smooth-muscle-cells-through-multiple-signaling-pathways
#18
Neal X Chen, Kalisha D O'Neill, Sharon M Moe
In patients with chronic kidney and end-stage renal diseases, the major risk factor for progression of arterial calcification is the presence of existing (baseline) calcification. Here, we tested whether calcification of arteries is extended from calcified vascular smooth muscle cells (VSMCs) to adjacent normal cells by matrix vesicle-induced alteration of cell signaling. Matrix vesicles isolated from VSMC of rats with chronic kidney disease were co-cultured with VSMCs from normal littermates. Endocytosis of vesicles by recipient cells was confirmed by confocal microscopy...
October 9, 2017: Kidney International
https://www.readbyqxmd.com/read/29032117/salvia-miltiorrhiza-protects-adenine-induced-chronic-renal-failure-by-regulating-the-metabolic-profiling-and-modulating-the-nadph-oxidase-ros-erk-and-tgf-%C3%AE-smad-signaling-pathways
#19
Hongdie Cai, Shulan Su, Yonghui Li, Huiting Zeng, Zhenhua Zhu, Jianming Guo, Yue Zhu, Sheng Guo, Li Yu, Dawei Qian, Yuping Tang, Jinao Duan
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic renal failure (CRF) is defined as a progressive and irreversible loss of renal function and associated with inflammation and oxidative stress. Salvia miltiorrhiza (SM) is an important Chinese herb used in traditional Chinese medicine with notable effects on CRF. It significantly inhibited the elevation of serum creatinine (Scr), blood urea nitrogen (BUN) and urine protein (UP) in adenine-induced CRF rats, while the action mechanism need to be illuminated deeply...
October 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29029099/biomarkers-of-mineral-and-bone-metabolism-and-20-year-risk-for-hospitalization-with-infection-the-aric-study
#20
Junichi Ishigami, Bernard G Jaar, Casey M Rebholz, Morgan E Grams, Erin D Michos, Myles Wolf, Csaba P Kovesdy, Shinichi Uchida, Josef Coresh, Pamela L Lutsey, Kunihiro Matsushita
Context: Mineral and bone disorders (MBD) may be relevant in the etiology of infection. Objective: To determine whether MBD biomarkers were associated with incidence of hospitalization with infection. We also assessed the cross-sectional association between levels of MBD biomarkers and kidney function. Design: Setting, Participants: Community-based cohort study using 11,218 participants with estimated glomerular filtration rate (eGFR) ≥30 ml/min/1...
September 27, 2017: Journal of Clinical Endocrinology and Metabolism
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