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JOURNAL ARTICLE
Azza Althagafi, Fernando Zhapa-Camacho, Robert Hoehndorf
MOTIVATION: Whole-exome and genome sequencing have become common tools in diagnosing patients with rare diseases. Despite their success, this approach leaves many patients undiagnosed. A common argument is that more disease variants still await discovery, or the novelty of disease phenotypes results from a combination of variants in multiple disease-related genes. Interpreting the phenotypic consequences of genomic variants relies on information about gene functions, gene expression, physiology, and other genomic features...
May 2, 2024: Bioinformatics
#2
JOURNAL ARTICLE
Anna Cecilia Lawson McLean, Aaron Lawson McLean, Thomas Ernst, Marie-Therese Forster, Christian Freyschlag, Jens Gempt, Roland Goldbrunner, Stefan Grau, Christine Jungk, Birgitt van Oorschot, Steffen K Rosahl, Ulrich Wedding, Christian Senft, Marcel A Kamp
PURPOSE: To benchmark palliative care practices in neurooncology centers across Germany, evaluating the variability in palliative care integration, timing, and involvement in tumor board discussions. This study aims to identify gaps in care and contribute to the discourse on optimal palliative care strategies. METHODS: A survey targeting both German Cancer Society-certified and non-certified university neurooncology centers was conducted to explore palliative care frameworks and practices for neurooncological patients...
May 2, 2024: Journal of Neuro-oncology
#3
JOURNAL ARTICLE
Peter R Jermain, Bryan Muir, Malcolm McEwen, Ying Niu, Dalong Pang
BACKGROUND: The newly available ZAP-X stereotactic radiosurgical system is designed for the treatment of intracranial lesions, with several unique features that include a self-shielding, gyroscopic gantry, wheel collimation, non-orthogonal kV imaging, short source-axis distance, and low-energy megavoltage beam. Systematic characterization of its radiation as well as other properties is imperative to ensure its safe and effective clinical application. PURPOSE: To accurately determine the radiation output of the ZAP-X with a special focus on the smaller diameter cones and an aim to provide useful recommendations on quantification of small field dosimetry...
May 2, 2024: Medical Physics
#4
JOURNAL ARTICLE
Justin Z Wang, Alexander P Landry, David R Raleigh, Felix Sahm, Kyle M Walsh, Roland Goldbrunner, Leeor S Yefet, Jörg C Tonn, Chloe Gui, Quinn T Ostrom, Jill Barnholtz-Sloan, Arie Perry, Yosef Ellenbogen, C Oliver Hanemann, Gerhard Jungwirth, Michael D Jenkinson, Ghazaleh Tabatabai, Tiit I Mathiesen, Michael W McDermott, Marcos Tatagiba, Christian la Fougère, Sybren L N Maas, Norbert Galldiks, Nathalie L Albert, Priscilla K Brastianos, Felix Ehret, Giuseppe Minniti, Katrin Lamszus, Franz L Ricklefs, Jens Schittenhelm, Katharine J Drummond, Ian F Dunn, Omar N Pathmanaban, Aaron Cohen-Gadol, Erik P Sulman, Emeline Tabouret, Emelie Le Rhun, Christian Mawrin, Jennifer Moliterno, Michael Weller, Wenya Linda Bi, Andrew Gao, Stephen Yip, Maximilian Niyazi, Kenneth Aldape, Patrick Y Wen, Susan Short, Matthias Preusser, Farshad Nassiri, Gelareh Zadeh
Meningiomas are the most common primary intracranial tumors in adults and are increasing in incidence due to the aging population and the rising availability of neuroimaging. While most exhibit non-malignant behaviour, a subset of meningiomas are biologically aggressive and lead to significant neurological morbidity and mortality. In recent years, meaningful advances in our understanding of the biology of these tumors have led to the incorporation of molecular biomarkers into their grading and prognostication...
May 2, 2024: Neuro-oncology
#5
JOURNAL ARTICLE
Peng Chen, Zhilei Guo, Jiexin Lei, Yulai Wang
Neuroinflammation may play an important role in the development of Alzheimer's disease (AD). Previous studies have reported that lipopolysaccharide (LPS)-induced neuroinflammation causes memory impairments and behavioral disorders. We investigated the potential preventive effects of punicalin (PUN), a polyphenolic component of pomegranate, on LPS-induced memory deficiency and anxiety- and depression-like behaviors, along with the underlying mechanisms. LPS-treated cultured microglial BV2 cells and BV2 cell/Neuro-2a (N2a) cell coculture system were investigated for anti-neuroinflammatory effects of PUN in vitro...
May 2, 2024: Phytotherapy Research: PTR
#6
JOURNAL ARTICLE
Josephine D Hendriksen, Alessio Locallo, Simone Maarup, Olivia Debnath, Naveed Ishaque, Benedikte Hasselbach, Jane Skjøth-Rasmussen, Christina Westmose Yde, Hans S Poulsen, Ulrik Lassen, Joachim Weischenfeldt
BACKGROUND: Glioblastoma is a highly aggressive type of brain tumour for which there is no curative treatment available. Immunotherapies have shown limited responses in unselected patients, and there is an urgent need to identify mechanisms of treatment resistance to design novel therapy strategies. METHODS: Here we investigated the phenotypic and transcriptional dynamics at single-cell resolution during nivolumab immune checkpoint treatment of glioblastoma patients...
May 2, 2024: Neuro-oncology
#7
EDITORIAL
Saurabh Agnihotri, Nalina Gupta, Pooja Sindwani, Ankita Srivastava, Aftab Ahmad, Medha Karki
Telerehabilitation is a burgeoning field that holds immense promise in revolutionizing the delivery of rehabilitation services. Defined as a branch of telecommunication utilizing technologies such as the internet, it facilitates remote interaction between healthcare providers and patients, transcending geographical barriers. This method proves invaluable in patient assessment, counseling, and treatment across various medical domains, including physical therapy, speech therapy, psychotherapy, and occupational therapy...
April 2024: Curēus
#8
JOURNAL ARTICLE
Zijia Tang, Tonglin Zhang, Qianqian Song, Jing Su, Baijian Yang
The irreversible and progressive atrophy by Alzheimer's Disease resulted in continuous decline in thinking and behavioral skills. To date, CNN classifiers were widely applied to assist the early diagnosis of AD and its associated abnormal structures. However, most existing black-box CNN classifiers relied heavily on the limited MRI scans, and used little domain knowledge from the previous clinical findings. In this study, we proposed a framework, named as PINet , to consider the previous domain knowledge as a Privileged Information (PI) , and open the black-box in the prediction process...
September 2023: ACM-BCB: ACM Conference on Bioinformatics, Computational Biology and Biomedicine
#9
REVIEW
Farzana Tariq, Fareed Jumah, Kaushik Ravipati, Michael Ortiz-Torres, Steven B Carr, Michael R Chicoine
The landscape of the cranial neurosurgery has changed tremendously in past couple of decades. The main frontiers including introduction of neuro-endoscopy, minimally invasive skull base approaches, SRS, laser interstitial thermal therapy and use of tubular retractors have revolutionized the management of intracerebral hemorrhages, deep seated tumors other intracranial pathologies. Introduction of these novel techniques is based on smaller incisions with maximal operative corridors, decreased blood loss, shorter hospital stays, decreased post-operative pain and cosmetically appealing scars that improves patient satisfaction and clinical outcomes...
2024: Missouri Medicine
#10
REVIEW
Burhan Kantawala, Sanobar Shariff, Nagham Ramadan, Violette Fawaz, Youmna Hassan, Nadine Mugisha, Konstantin Yenkoyan, Abubakar Nazir, Olivier Uwishema
INTRODUCTION: The blood-brain barrier (BBB) is a critical neurovascular unit regulating substances' passage from the bloodstream to the brain. Its selective permeability poses significant challenges in drug delivery for neurological disorders. Conventional methods often fail due to the BBB's complex structure. AIM: The study aims to shed light on their pivotal role in revolutionizing neurotherapeutics and explores the transformative potential of BBB-on-a-Chip technologies in drug delivery research to comprehensively review BBB-on-a-chip technologies, focusing on their design, and substantiate advantages over traditional models...
May 2024: Annals of Medicine and Surgery
#11
JOURNAL ARTICLE
Wenjun Song, Graham E Holder, Rupesh Agrawal, Melissa C H Tien
No abstract text is available yet for this article.
May 2, 2024: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
#12
COMPARATIVE STUDY
Raúl Caulier-Cisterna, Juan-Pablo Appelgren-Gonzáles, Juan-Esteban Oyarzún, Felipe Valenzuela, Ranganatha Sitaram, Antonio Eblen-Zajjur, Sergio Uribe
Recently, functional Near-Infrared Spectroscopy (fNIRS) was applied to obtain, non-invasively, the human peri‑spinal Neuro-Vascular Response (NVR) under a non-noxious electrical stimulation of a peripheral nerve. This method allowed the measurements of changes in the concentration of oxyhemoglobin (O2 Hb) and deoxyhemoglobin (HHb) from the peri‑spinal vascular network. However, there is a lack of clarity about the potential differences in perispinal NVR recorded by the different fNIRS technologies currently available...
May 2024: Medical Engineering & Physics
#13
JOURNAL ARTICLE
Suzanna Joseph, Rizul Naithani, Samuel Alvarez, Tanya Glaser, Sharon Freedman, Mays El-Dairi
BACKGROUND: Infantile nystagmus syndrome can be associated with an afferent problem (anterior or posterior segment) or constitute an isolated idiopathic disorder. With a normal ophthalmic examination, current guidelines recommend electroretinography (ERG) rather than magnetic resonance (MRI) for preliminary workup. Given the limited use of optical coherence tomography (OCT) in preverbal children, the purpose of this study was to evaluate the role of handheld OCT (HH-OCT) in the initial diagnostic evaluation of infantile nystagmus...
April 29, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
#14
REVIEW
P Phylactou, T N M Pham, N Narskhani, N Diya, D A Seminowicz, S M Schabrun
Transcranial magnetic stimulation (TMS) is commonly delivered at an intensity defined by the resting motor threshold (rMT), which is thought to represent cortical excitability, even if the TMS target area falls outside of the motor cortex. This approach rests on the assumption that cortical excitability, as measured through the motor cortex, represents a 'global' measure of excitability. Another common approach to measure cortical excitability relies on the phosphene threshold (PT), measured through the visual cortex of the brain...
April 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
#15
JOURNAL ARTICLE
Yilin Tang, Yuting Li, Peiyu Cao, Yingbo Dong, Guoxin Xu, Qi Si, Runda Li, Yuxiu Sui
BACKGROUND: The basal ganglia are important structures for the release of dopamine in the limbic circuits of the midbrain, and the striatum and globus pallidus are the major nuclei of the basal ganglia, and the dysfunction of these regions has been the basis of many models that have attempted to explain the underlying mechanisms of schizophrenia symptoms. The purpose of this study was to investigate the changes in the volume of the striatum subregion and globus pallidus in three different stages of schizophrenia, and to analyze whether these volume changes were related to antipsychotic drugs and schizophrenia symptoms...
April 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
#16
JOURNAL ARTICLE
Juliano Ten Kathen Jung, Luiza Souza Marques, Carlos Alexandre Brambila, Bruna da Cruz Webber Fulco, Cristina Wayne Nogueira, Gilson Zeni
Stress exposure can lead to post-traumatic stress disorder (PTSD) in male and female rats. Social-Single Prolonged Stress (SPS) protocol has been considered a potential PTSD model. This study aimed to pharmacologically validate the Social-SPS as a PTSD model in male and female rats. Male and female Wistar rats (60-day-old) were exposed to Social-SPS protocol and treated with fluoxetine (10 mg/Kg) or saline solution intraperitoneally 24 h before euthanasia. Two cohorts of animals were used; for cohort 1, male and female rats were still undisturbed until day 7 post-Social-SPS exposure, underwent locomotor and conditioned fear behaviors, and were euthanized on day 9...
April 29, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
#17
JOURNAL ARTICLE
Hao Jin, Mengtong Li, Eric Jeong, Felipe Castro-Martinez, Charles S Zuker
The body-brain axis is emerging as a principal conductor of organismal physiology. It senses and controls organ function1,2 , metabolism3 and nutritional state4-6 . Here, we show that a peripheral immune insult powerfully activates the body-brain axis to regulate immune responses. We demonstrate that pro- and anti-inflammatory cytokines communicate with distinct populations of vagal neurons to inform the brain of an emerging inflammatory response. In turn, the brain tightly modulates the course of the peripheral immune response...
May 1, 2024: Nature
#18
JOURNAL ARTICLE
Pritesh N Parmar, James L Patton
Our study addresses the critical question of how learners acquire skills without the constant crutch of feedback, utilizing a specialized training approach with intermittent feedback. Despite recognized benefits in skill retention, the underlying mechanisms of intermittent feedback in motor control neuroscience remain elusive. Leveraging a previously published dataset from visuomotor learning experiments with intermittent feedback, we tested a wide range of proxy-process models that posit the presence of an inferred error signal even when an explicit sensory performance is not present...
May 1, 2024: Journal of Neurophysiology
#19
JOURNAL ARTICLE
Ameya D Puranik, Indraja D Dev, Venkatesh Rangarajan, Suyash Kulkarni, Nitin Shetty, Kunal Gala, Arpita Sahu, Kajari Bhattacharya, Archya Dasgupta, Abhishek Chatterjee, Tejpal Gupta, Epari Sridhar, Ayushi Sahay, Prakash Shetty, Vikas Singh, Aliasgar Moiyadi, Nandini Menon, Nilendu C Purandare, Archi Agrawal, Sneha Shah, Sayak Choudhury, Suchismita Ghosh, Ashish Kumar Jha
PURPOSE: Refractory and/or recurrent meningiomas have poor outcomes, and the treatment options are limited. Peptide receptor radionuclide therapy (PRRT) has been used in this setting with promising results. We have documented our experience of using intravenous (IV) and intra-arterial (IA) approaches of Lu-177 DOTATATE PRRT. METHODS: Eight patients with relapsed/refractory high-grade meningioma received PRRT with Lu-177 DOTATATE by IV and an IA route. At least 2 cycles were administered...
March 1, 2024: Neurology India
#20
Ann Pongsakul, Amy Daniel, Roddy Lochala, David E Martin
Intracerebral hemorrhage (ICH) is a rare and severe complication of immune thrombocytopenic purpura (ITP) that can be spontaneous. Viral illnesses, other infections, autoimmune disorders, and medications can cause ITP. ITP causes a significant decrease in platelet levels, increasing bleeding risk. ITP can be treated by steroids, intravenous immunoglobulin, plasmapheresis, platelet transfusion, biological agents, and splenectomy. ICH treatment involves the treatment of underlying ITP, as well as any neuro-interventional procedures needed...
March 2024: Curēus
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