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https://www.readbyqxmd.com/read/28528477/human-cost-burden-of-exposure-to-endocrine-disrupting-chemicals-a-critical-review
#1
REVIEW
Gregory G Bond, Daniel R Dietrich
Recently published papers have alleged that exposures to endocrine disrupting chemicals (EDCs) are causing substantial disease burdens in the EU and US and are consequently costing society hundreds of billions of dollars annually. To date, these cost estimates have not undergone adequate scientific scrutiny, but nevertheless are being used aggressively in advocacy campaigns in an attempt to fundamentally change how chemicals are tested, evaluated and regulated. Consequently, we critically evaluated the underlying methodology and assumptions employed by the chief architects of the disease burden cost estimates...
May 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28528404/a-direct-comparison-of-the-effects-of-the-antiretroviral-drugs-stavudine-tenofovir-and-the-combination-lopinavir-ritonavir-on-bone-metabolism-in-a-rat-model
#2
M M Conradie, M van de Vyver, E Andrag, M Conradie, W F Ferris
Antiretroviral (ARV) treatment may induce metabolic complications in HIV patients on long-term therapy that can affect bone health. In this study, the effects of the ARVs Stavudine (d4T), Tenofovir (TDF) and Lopinavir/ritonavir (LPV/r) on bone metabolism and lipodystrophy were directly compared in rats to negate the consequences of HIV-associated confounding factors. Healthy 12-14-week-old male Wistar rats (n = 40) were divided into four treatment groups and received an oral animal equivalent dose of either Stavudine (6...
May 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28528340/evaluation-of-hypocaloric-diet-with-protein-supplementation-in-middle-aged-sarcopenic-obese-women-a-pilot-study
#3
Rosa Sammarco, Maurizio Marra, Maria Luisa Di Guglielmo, Marianna Naccarato, Franco Contaldo, Eleonora Poggiogalle, Lorenzo Maria Donini, Fabrizio Pasanisi
OBJECTIVE: The aim of this study was to evaluate the efficacy of a nutritional program, which is characterized by a different modulation of proteins, in adult patients with sarcopenic obesity. METHODS: We studied 18 obese women aged 41-74 years. Obesity was diagnosed as fat mass > 34.8% and sarcopenia was defined when lean body mass was <90% of the subject's ideal fat free mass. All subjects were randomly assigned to different nutritional interventions: Hypocaloric diet plus placebo (A) and hypocaloric high-protein diet (1...
May 20, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28528117/composite-elastomeric-polyurethane-scaffolds-incorporating-small-intestinal-submucosa-for-soft-tissue-engineering
#4
Lincui Da, Mei Gong, Anjing Chen, Yi Zhang, Yizhou Huang, Zhijun Guo, Shengfu Li, Jesse Li-Ling, Li Zhang, Huiqi Xie
Although soft tissue replacement has been clinically successful in many cases, the corresponding procedure has many limitations including the lack of resilience and mechanical integrity, significant donor-site morbidity, volume loss with time, and fibrous capsular contracture. These disadvantages can be alleviated by utilizing bio-absorbable scaffolds with high resilience and large strain, which are capable of stimulating natural tissue regeneration. Hence, the chemically crosslinked tridimensional scaffolds obtained by incorporating water-based polyurethane (PU) (which was synthesized from polytetramethylene ether glycol, isophorone diisocyanate, and 2,2-bis(hydroxymethyl) butyric acid) into a bioactive extracellular matrix consisting of small intestinal submucosa (SIS) have been tested in this study to develop a new approach for soft tissue engineering...
May 17, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28527966/suture-dehiscence-in-the-tricuspid-annulus-an-ex%C3%A2-vivo-analysis-of-tissue-strength-and-composition
#5
Deborah M Paul, Ajay Naran, Eric L Pierce, Charles H Bloodworth, Steven F Bolling, Ajit P Yoganathan
BACKGROUND: Surgical repair of functional tricuspid regurgitation (FTR) is an increasingly common practice, but annuloplasty suture dehiscence remains a significant problem. Quantitative and mechanistic understanding of annular suture holding strength can support more effective techniques for tricuspid valve device anchoring. METHODS: Suture holding strength of ovine tricuspid annuli (n = 15) was quantified ex vivo by pullout testing at 12 positions around their circumference...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28527901/photonic-ring-resonance-is-a-versatile-platform-for-performing-multiplex-immunoassays-in-real-time
#6
Sasi Mudumba, Sophia de Alba, Randy Romero, Carli Cherwien, Alice Wu, Jue Wang, Martin A Gleeson, Muzammil Iqbal, Rufus W Burlingame
Photonic ring resonance is a property of light where in certain circumstances specific wavelengths are trapped in a ring resonator. Sensors based on silicon photonic ring resonators function by detecting the interaction between light circulating inside the sensor and matter deposited on the sensor surface. Binding of biological material results in a localized change in refractive index on the sensor surface, which affects the circulating optical field extending beyond the sensor boundary. That is, the resonant wavelength will change when the refractive index of the medium around the ring resonator changes...
May 17, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28527852/cyclic-and-torsional-fatigue-resistance-of-reciprocating-single-files-manufactured-by-different-nickel-titanium-alloys
#7
Murilo P Alcalde, Mario Tanomaru-Filho, Clovis M Bramante, Marco Antonio H Duarte, Juliane Maria Guerreiro-Tanomaru, Jader Camilo-Pinto, Marcus Vinicius Reis Só, Rodrigo Ricci Vivan
INTRODUCTION: The aim of this study was to evaluate the cyclic and torsional fatigue resistance of the following reciprocating single-file systems: ProDesign R 25.06 (Easy Equipamentos Odontológicos, Belo Horizonte, Brazil), Reciproc R25 (VDW GmbH, Munich, Germany), and Unicone L25 (Medin SA, Nové Město in Moravě, Czech Republic). METHODS: Sixty instruments of the ProDesign R, Reciproc R25, and Unicone L25 systems (n = 20) were used. Cyclic fatigue resistance was tested measuring the time to failure in an artificial stainless steel canal with a 60° angle and a 5-mm radius of curvature (n = 10)...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527844/evaluation-of-various-pretreatments-to-fiber-post-on-the-push-out-bond-strength-of-root-canal-dentin
#8
Ömer Kırmalı, Özlem Üstün, Alper Kapdan, Alper Kuştarcı
INTRODUCTION: The aim of this in vitro study was to compare the effect of different pretreatments (fiber post) with the laser-activated irrigation (LAI) technique (for removal of the smear layer) on root canal dentin in terms of push-out bond strength (PBS) in a fiber post. METHODS: Fifty freshly extracted mandibular single-rooted premolars were prepared, and LAI was applied to all roots (17% EDTA was 5 mL for 120 seconds with an erbium, chromium:yttrium-scandium-gallium-garnet laser [0...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527477/secular-trends-in-anthropometrics-and-physical-fitness-of-young-portuguese-school-aged-children
#9
Aldo Matos Costa, Mário Jorge Costa, António Antunes Reis, Sandra Ferreira, Júlio Martins, Ana Pereira
INTRODUCTION: The purpose of this study was to analyze secular trends in anthropometrics and physical fitness of Portuguese children. MATERIAL AND METHODS: A group of 1819 students (881 boys and 938 girls) between 10 and 11 years old was assessed in their 5th and 6th scholar grade throughout a 20 years' time-frame. ANCOVA models were used to analyze variations in anthropometrics (height, weight and body mass index) and physical fitness (sit and reach, curl-up, horizontal jump and sprint time) across four quinquennials (1993 - 1998; 1998 - 2003; 2003 - 2008; 2008 - 2013)...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28527227/correlation-of-the-gait-speed-with-the-quality-of-life-and-the-quality-of-life-classified-according-to-speed-based-community-ambulation-in-thai-stroke-survivors
#10
Phichamon Khanittanuphong, Suttipong Tipchatyotin
BACKGROUND: Gait abnormality commonly resulted from stroke which affected patients living and probably quality of life (QOL). OBJECTIVE: To assess the relationship between gait speed and the QOL in Thai stroke patients and to compare the QOL among three patient groups that were categorized by gait speed: i) household ambulators <0.4 m/s, ii) limited community ambulators 0.4-0.8 m/s and iii) community ambulators >0.8 m/s. METHODS: This was a cross-sectional descriptive research study...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28527191/understanding-how-a-sport-helmet-protects-the-head-from-closed-injury-by-virtual-impact%C3%A2-tests
#11
Yunhua Luo, Zhaoyang Liang
Understanding how a helmet protects the head, especially the soft brain tissues, is the prerequisite for improving helmet design. Intracranial pressure and stresses/strains in the brain tissues are the direct indicators of traumatic brain injury and they can be used to measure helmet performance. In this study, the effects of helmet design parameters such as the helmet shell stiffness, liner compliance and thickness on the brain injury indicators were investigated by virtual impact tests. A finite element head model (FEHM) was first constructed from medical images; a personally-fitted helmet made of composite material and foam was virtually prototyped using geometric information extracted from the FEHM; a helmet-head finite element model was then assembled...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28527156/the-effect-of-aerobic-or-aerobic-strength-exercise-on-body-composition-and-functional-capacity-in-patients-with-bmi-%C3%A2-35-after-bariatric-surgery-a-randomized-control-trial
#12
Alireza Hassannejad, Alireza Khalaj, Mohammad Ali Mansournia, Mastaneh Rajabian Tabesh, Zahra Alizadeh
BACKGROUND: Although previous studies suggested that bariatric surgery is the most effective and sustainable treatment method for morbid obesity in long term, but without changing in lifestyle, maintaining optimal weight loss is almost impossible. METHODS: Sixty morbid obese patients (BMI ≥ 35) were evaluated before and after 12 weeks of bariatric surgery in order to compare the impact of two different exercise programs on body composition and functional capacity outcomes...
May 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28527048/interpreting-findings-from-mendelian-randomization-using-the-mr-egger-method
#13
Stephen Burgess, Simon G Thompson
Mendelian randomization-Egger (MR-Egger) is an analysis method for Mendelian randomization using summarized genetic data. MR-Egger consists of three parts: (1) a test for directional pleiotropy, (2) a test for a causal effect, and (3) an estimate of the causal effect. While conventional analysis methods for Mendelian randomization assume that all genetic variants satisfy the instrumental variable assumptions, the MR-Egger method is able to assess whether genetic variants have pleiotropic effects on the outcome that differ on average from zero (directional pleiotropy), as well as to provide a consistent estimate of the causal effect, under a weaker assumption-the InSIDE (INstrument Strength Independent of Direct Effect) assumption...
May 19, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28526918/effect-of-problem-and-scripting-based-learning-on-spine-surgical-trainees-learning-outcomes
#14
Lin Cong, Qi Yan, Chenjing Sun, Yue Zhu, Guanjun Tu
PURPOSE: To assess the impact of problem and scripting-based learning (PSBL) on spine surgical trainees' learning outcomes. METHODS: 30 spine surgery postgraduate-year-1 residents (PGY-1s) from the First Hospital of China Medical University were randomly divided into two groups. The first group studied spine surgical skills and developed individual judgment under a conventional didactic model, whereas the PSBL group used PBL and Scripted model. A feedback questionnaire and the satisfaction of residents were evaluated by the first assistant surgeon immediately following each procedure...
May 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28526899/electricity-generation-from-real-industrial-wastewater-using-a-single-chamber-air-cathode-microbial-fuel-cell-with-an-activated-carbon-anode
#15
Hend Omar Mohamed, M Obaid, Enas Taha Sayed, Yang Liu, Jinpyo Lee, Mira Park, Nasser A M Barakat, Hak Yong Kim
This study introduces activated carbon (AC) as an effective anode for microbial fuel cells (MFCs) using real industrial wastewater without treatment or addition of external microorganism mediators. Inexpensive activated carbon is introduced as a proper electrode alternative to carbon cloth and carbon paper materials, which are considered too expensive for the large-scale application of MFCs. AC has a porous interconnected structure with a high bio-available surface area. The large surface area, in addition to the high macro porosity, facilitates the high performance by reducing electron transfer resistance...
May 19, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28526822/shortest-paths-in-multiplex-networks
#16
Saeed Ghariblou, Mostafa Salehi, Matteo Magnani, Mahdi Jalili
The shortest path problem is one of the most fundamental networks optimization problems. Nowadays, individuals interact in extraordinarily numerous ways through their offline and online life (e.g., co-authorship, co-workership, or retweet relation in Twitter). These interactions have two key features. First, they have a heterogeneous nature, and second, they have different strengths that are weighted based on their degree of intimacy, trustworthiness, service exchange or influence among individuals. These networks are known as multiplex networks...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526625/effects-of-resistance-training-frequency-on-cardiorespiratory-fitness-in-older-men-and-women-during-intervention-and-follow-up
#17
Elena Fernández-Lezaun, Moritz Schumann, Tuomas Mäkinen, Heikki Kyröläinen, Simon Walker
This study investigated the effects of resistance training (RT) performed with different frequencies, including a follow-up period, on cardiorespiratory fitness in healthy older individuals. Eighty-eight men and women (69±3years, 167±9cm and 78±14kg) were randomly placed into four groups: training one- (M1=11, W1=12), two- (M2=7, W2=14), or three- (M3=11, W3=13) times-per-week or a non-training control group (MCon=11, WCon=9). During months 1-3, all subjects trained two-times-per-week while during the subsequent 6months, training frequency was set according to the group...
May 16, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28526443/mechanical-properties-of-polymer-infiltrated-ceramic-sodium-aluminum-silicate-composites-for-dental-restoration
#18
Bencang Cui, Jing Li, Huining Wang, Yuanhua Lin, Yang Shen, Ming Li, Xuliang Deng, Cewen Nan
OBJECTIVE: To fabricate indirect restorative composites for CAD/CAM applications and evaluate the mechanical properties. METHODS: Polymer-infiltrated-ceramic composites were prepared through infiltrating polymer into partially sintered sodium aluminum silicate ceramic blocks and curing. The corresponding samples were fabricated according to standard ISO-4049 using for mechanical properties measurement. The flexural strength and fracture toughness were measured using a mechanical property testing machine...
May 16, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28526421/delayed-repair-of-distal-biceps-tendon-ruptures-is-successful-a-case-control-study
#19
John Haverstock, Ruby Grewal, Graham J W King, George S Athwal
BACKGROUND: The literature has shown an increased complication rate with a delay to surgical repair of acute distal biceps tendon ruptures; however, little has been documented regarding the outcome of delayed repairs. This case-control study compared a study cohort of delayed (>21 days) distal biceps tendon repairs with a control cohort repaired acutely (<21 days). METHODS: Sixteen delayed repair cases were reviewed and matched with acute controls (1:3) based on repair technique, age, and workers' compensation status...
June 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28526219/cardiorespiratory-fitness-and-muscular-strength-as-mediators-of-the-influence-of-fatness-on-academic-achievement
#20
Antonio García-Hermoso, Irene Esteban-Cornejo, Jordi Olloquequi, Robinson Ramírez-Vélez
OBJECTIVE: To examine the combined association of fatness and physical fitness components (cardiorespiratory fitness [CRF] and muscular strength) with academic achievement, and to determine whether CRF and muscular strength are mediators of the association between fatness and academic achievement in a nationally representative sample of adolescents from Chile. STUDY DESIGN: Data were obtained for a sample of 36 870 adolescents (mean age, 13.8 years; 55.2% boys) from the Chilean System for the Assessment of Educational Quality test for eighth grade in 2011, 2013, and 2014...
May 16, 2017: Journal of Pediatrics
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