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https://www.readbyqxmd.com/read/29778554/cumulative-live-birth-rates-after-ivf-in-patients-with-polycystic-ovaries-phenotype-matters
#1
Michel De Vos, Stéphanie Pareyn, Panagiotis Drakopoulos, José M Raimundo, Ellen Anckaert, Samuel Santos-Ribeiro, Nikolaos P Polyzos, Herman Tournaye, Christophe Blockeel
RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment? DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed...
May 7, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29778387/major-depression-antidepressant-use-and-male-and-female-fertility
#2
Emily A Evans-Hoeker, Esther Eisenberg, Michael P Diamond, Richard S Legro, Ruben Alvero, Christos Coutifaris, Peter R Casson, Gregory M Christman, Karl R Hansen, Heping Zhang, Nanette Santoro, Anne Z Steiner
OBJECTIVE: To determine if maternal major depression (MD), antidepressant use, or paternal MD are associated with pregnancy outcomes after non-IVF fertility treatments. DESIGN: Cohort study. SETTING: Clinics. PATIENT(S): Participants in two randomized trials: PPCOS II (clomiphene citrate versus letrozole for polycystic ovary syndrome), and AMIGOS (gonadotropins versus clomiphene citrate versus letrozole for unexplained infertility)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778383/in-vitro-fertilization-interpregnancy-interval-and-risk-of-adverse-perinatal-outcomes
#3
Kristin Palmsten, Michael V Homer, Yujia Zhang, Sara Crawford, Russell S Kirby, Glenn Copeland, Christina D Chambers, Dmitry M Kissin, H Irene Su
OBJECTIVE: To compare associations between interpregnancy intervals (IPIs) and adverse perinatal outcomes in deliveries following IVF with deliveries following spontaneous conception or other (non-IVF) fertility treatments. DESIGN: Cohort using linked birth certificate and assisted reproductive technology surveillance data from Massachusetts and Michigan. SETTING: Not applicable. PATIENT(S): 1,225,718 deliveries. INTERVENTION(S): None...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778368/oral-dydrogesterone-for-luteal-phase-support-in-fresh-in-vitro-fertilization-cycles-a-new-standard
#4
REVIEW
Georg Griesinger, Christophe Blockeel, Herman Tournaye
Oral dydrogesterone has been used for luteal phase support on an empirical basis since the early days of in vitro fertilization (IVF) treatment. Systematic comparisons of oral dydrogesterone with vaginal progesterone, so far considered to be the standard of care, started to appear in the middle 2000s. Recently, a large, randomized, double-blind, double-dummy phase III trial on the use of daily 30 mg oral dydrogesterone versus daily 600 mg micronized vaginal progesterone for LPS in IVF was published. This company-sponsored trial confirmed the efficacy findings from previous independent researchers and firmly established the noninferiority of daily 30 mg oral dydrogesterone for luteal phase support...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29773699/comparison-of-the-effect-of-immediate-versus-delayed-transfer-following-a-stimulated-ivf-cycle-on-the-ongoing-pregnancy-rate-of-frozen-thawed-embryo-transfer-cycles-a-study-protocol-for-a-randomised-controlled-trial
#5
He Li, Lu Li, Xiang Lu, Xiaoxi Sun, Ernest Hung Yu Ng
INTRODUCTION: Frozen-thawed embryo transfer (FET) has become an increasingly important part of in-vitro fertilisation (IVF) treatment. Currently, there is still no good scientific evidence to support when to perform FET following a stimulated IVF cycle. Since all published studies are retrospective and the findings are contradictory, a randomised controlled study is needed to provide Level 1 evidence to guide the clinical practice. METHODS/ANALYSIS: This is a randomised controlled trial...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29766148/endogenous-luteinizing-hormone-concentration-and-ivf-outcome-during-ovarian-stimulation-in-fixed-versus-flexible-gnrh-antagonist-protocols-an-rct
#6
Raffaella Depalo, Paolo Trerotoli, Annarosa Chincoli, Margherita Patrizia Vacca, Giuseppina Lamanna, Ettore Cicinelli
Background: Luteinizing hormone (LH) is essential for normal follicular development and oocyte maturation. In particular, fluctuations of LH during the follicular phase have a significant impact on morphological and functional changes of the oocyte and determine its meiotic status and ability to be fertilized. Objective: This prospective randomized controlled trial examined effects of endogenous follicular phase LH levels on oocyte maturity and IVF outcomes in fixed vs...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29744474/utilization-of-cryopreserved-sperm-cells-based-on-the-indication-for-storage
#7
Graham Luke Machen, Stephanie E Harris, Erin T Bird, Monica L Brown, Dale A Ingalsbe, Milaida M East, Michelle Reyes, Thomas J Kuehl
Purpose: Cryopreservation of sperm from human semen has been available since the 1950s. The actual utilization of available cryopreservation technology has been infrequently reported. We set out to examine the utilization and outcomes of cryopreserved sperm cells based on the indication for storage. Materials and Methods: A dataset was developed from retrospective review. The purposes for cryopreservation, eventual utilization, and outcomes of use for insemination were recorded...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29743877/follicle-size-on-day-of-trigger-most-likely-to-yield-a-mature-oocyte
#8
Ali Abbara, Lan N Vuong, Vu N A Ho, Sophie A Clarke, Lisa Jeffers, Alexander N Comninos, Rehan Salim, Tuong M Ho, Tom W Kelsey, Geoffrey H Trew, Peter Humaidan, Waljit S Dhillo
Objective: To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment. Design: Retrospective analysis to determine the size of follicles on day of trigger contributing most to the number of mature oocytes retrieved using generalized linear regression and random forest models applied to data from IVF cycles (2014-2017) in which either hCG, GnRHa, or kisspeptin trigger was used...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29739361/two-successful-pregnancies-following-fertility-preservation-in-a-patient-with-anaplastic-astrocytoma-a-case-report
#9
Alexandra Peyser, Sara L Bristow, Avner Hershlag
BACKGROUND: Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, fertility preservation prior to chemotherapy and/or radiation therapy should be considered. This requires close collaboration between the oncologist and reproductive endocrinologist. To our knowledge this is the first report of successful pregnancies following fertility preservation for AA...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29738982/anti-m%C3%A3-llerian-hormone-levels-are-associated-with-live-birth-rates-in-art-but-the-predictive-ability-of-anti-m%C3%A3-llerian-hormone-is-modest
#10
Sara S E Alson, Leif J Bungum, Aleksander Giwercman, Emir Henic
OBJECTIVES: The aim was to evaluate the association between serum Anti-Müllerian Hormone (AMH) level and cumulative live birth rates (LBR) in patients undergoing their first in vitro fertilization (IVF) treatment cycle, and to compare serum AMH levels with Antral Follicle Count (AFC) and Ovarian Sensitivity Index (OSI) as predictors of live birth. STUDY DESIGN: A prospective cohort study of 454 patients under the age of 40 and with a regular menstrual cycle of 21-35 days, undergoing their first IVF treatment cycles between September 2010 and June 2015...
May 2, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29733525/m-carboxycinnamic-acid-bishydroxamide-improves-developmental-competence-reduces-apoptosis-and-alters-epigenetic-status-and-gene-expression-pattern-in-cloned-buffalo-bubalus-bubalis-embryos
#11
H Agrawal, N L Selokar, M Saini, M K Singh, M S Chauhan, P Palta, S K Singla, R S Manik
Incomplete or aberrant reprogramming of nuclear genome is one of the major problems in somatic cell nuclear transfer. In this study, we studied the effect of histone deacetylase inhibitor m-carboxycinnamic acid bishydroxamide (CBHA) on in vitro development of buffalo embryos produced by Hand-made cloning. Cloned embryos were treated with CBHA (0, 5, 10, 20 or 50 μM) for 10 hr from the start of reconstruction till activation. At 10 μM, but not at other concentrations examined, CBHA increased (p < ...
May 7, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29728130/low-dose-clomiphene-citrate-as-a-mild-stimulation-protocol-in-women-with-unsuspected-poor-in-vitro-fertilization-result-can-generate-more-oocytes-with-optimal-cumulative-pregnancy-rate
#12
Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui, Jiayin Liu
BACKGROUND: The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dose gonadotropins could be useful alternative regimen to address such problems. This study evaluated the efficacy of low dose clomiphene citrate based protocol plus low dose gonadotropins on predicted normal responder patients who had unsuspected poor in vitro fertilization (IVF) result, following an initial stimulation with long gonadotropin-releasing hormone (GnRH) agonist protocol...
May 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29726701/clinical-efficacy-and-mechanism-of-growth-hormone-action-in-patients-experiencing-repeat-implantation-failure
#13
Ye Chen, Fenghua Liu, Yingqi Nong, Jianxing Ruan, Qingqing Guo, Ming Luo, Qianwen Huang
OBJECTIVES: To investigate the clinical efficacy of growth hormone (GH) in patients experiencing repeat implantation failure (RIF) and explore the possible mechanism. METHODS: Forty-two RIF patients undergoing in vitro fertilization-embryo transfer (IVF-ET) were enrolled in the present trial: 22 patients who received GH (treatment group) and 20 who did not receive GH (controls). RESULTS: The clinical pregnancy and live birth rates in the treatment group were significantly higher than those in the control group (both P<0...
May 4, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29713857/case-of-successful-ivf-treatment-of-an-oligospermic-male-with-46-xx-46-xy-chimerism
#14
R J Laursen, B Alsbjerg, I Vogel, C H Gravholt, H Elbaek, D L Lildballe, P Humaidan, E M Vestergaard
INTRODUCTION: We present a case of an infertile male with 46,XX/46,XYchimerism fathering a child after ICSI procedure. METHODS: Conventional cytogenetic analysis on chromosomes, derived from lymphocytes, using standard Q-banding procedures with a 450-550-band resolution and short-tandem-repeat analysis of 14 loci. RESULTS: Analysis of 20 metaphases from lymphocytes indicated that the proband was a karyotypic mosaic with an almost equal distribution between male and female cell lines...
April 30, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29713550/role-of-varicocele-treatment-in-assisted-reproductive-technologies
#15
REVIEW
Mehmet G Sönmez, Ahmet H Haliloğlu
Objective: In this review, we investigate the advantage of varicocele repair prior to assisted reproductive technologies (ART) for infertile couples and provide cost analysis information. Materials and methods: We searched the following electronic databases: PubMed, Medline, Excerpta Medica Database (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL). The following search strategy was modified for the various databases and search engines: 'varicocele', 'varicocelectomy', 'varicocele repair', 'ART', ' in vitro fertilisation (IVF)', 'intracytoplasmic sperm injection (ICSI)'...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29709727/clinical-outcomes-of-a-vitrified-donor-oocyte-programme-a-single-uk-centre-experience
#16
S Seshadri, W Saab, H Exeter, E Drew, A Petrie, M Davies, P Serhal
OBJECTIVE: To assess the survival rate of vitrified oocytes used in an egg recipient programme and compare the clinical outcomes of pregnancy and live-birth rates per warmed oocyte with fresh autologous oocytes. The differences in the obstetrical outcomes between the two groups were also studied. DESIGN: A prospective case control study from a single in-vitro fertilisaton (IVF) Centre in UK SETTING: Centre of Reproductive and Genetic Health (CRGH), London POPULATION: Vitrified oocytes from egg donors and autologous fresh oocytes from patients attending for an IVF cycle METHODS: The study group consisted of 1490 vitrified oocytes, which were obtained from 145 egg donors who underwent a stimulation cycle at CRGH Centre...
April 22, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29707689/new-ambulatory-hysteroscopic-septoplasty-using-ballooning-in-a-woman-with-complete-septate-uterus-a-case-report
#17
Jung Hyun Cho, Hyung Jae Won, Mi Kyoung Kim, Ju Hee Park, Ju Youn Hwang
A 40-year-old G1 P0 L0 A1 woman was referred to our clinic with 6-year history of infertility. Before visiting the clinic, she had 3 cycles of In-Vitro Fertilization (IVF) procedures (2 cycles of Controlled Ovarian Stimulation-IVF and 1 cycle of frozen-thawed Embryo Transfer (ET)) at other clinic. She had medical history of abortion at early gestation following FET (frozen-thawed-ET). The patient had complete type of septate uterus, double cervix and longitudinal vaginal septum. Vaginal septotomy was done first and 1 month later, hysteroscopic septoplasty was followed using ballooning filled with dye...
March 2018: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29704433/retrievable-hydrogels-for-ovarian-follicle-transplantation-and-oocyte-collection
#18
Peter D Rios, Ekaterina Kniazeva, Hoi Chang Lee, Shuo Xiao, Robert S Oakes, Eiji Saito, Jacqueline S Jeruss, Ariella Shikanov, Teresa K Woodruff, Lonnie D Shea
Cancer survivorship rates have drastically increased due to improved efficacy of oncologic treatments. Consequently, clinical concerns have shifted from solely focusing on survival to quality of life, with fertility preservation as an important consideration. Among fertility preservation strategies for female patients, ovarian tissue cryopreservation and subsequent re-implantation has been the only clinical option available to cancer survivors with cryopreserved tissue. However, follicle atresia post-transplantation and risk of re-introducing malignant cells have prevented this procedure from becoming widely adopted in clinics...
April 28, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29703793/liraglutide-increases-ivf-pregnancy-rates-in-obese-pcos-women-with-poor-response-to-first-line-reproductive-treatments-a-pilot-randomized-study
#19
Vesna Salamun, Mojca Jensterle, Andrej Janez, Eda Vrtacnik Bokal
OBJECTIVE: Glucagon-like peptide-1 (GLP-1) has been investigated in regulation of reproductive system in animal models. The potential impact of short-term preconception intervention with liraglutide on fertility potential in PCOS has not been evaluated yet. DESIGN: A prospective randomized open-label study was conducted in 28 infertile obese PCOS patients (age 31.07±4.75 years, BMI 36.7±3.5 kg/m2, mean±SD). They were assigned to metformin (MET) 1000 mg BID or to MET 1000 mg BID combined with low-dose liraglutide 1...
April 27, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29703435/very-low-anti-m%C3%A3-llerian-hormone-concentrations-are-not-an-independent-predictor-of-embryo-quality-and-pregnancy-rate
#20
Alberto Pacheco, María Cruz, Carlos Iglesias, Juan Antonio García-Velasco
RESEARCH QUESTION: Is anti-Müllerian hormone (AMH) serum concentration a useful tool to predict the outcome of assisted reproductive treatment? DESIGN: Retrospective cohort study involving 2971 patients who underwent 5570 IVF cycles. Patients were classified into six groups according to their AMH levels and analysed for associations with reproductive outcome. Several parameters of ovarian response and clinical outcome were compared between groups. RESULTS: Cancellation rate and clinical pregnancy rate varied by AMH group, with highest cancellation rates (32...
April 6, 2018: Reproductive Biomedicine Online
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