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https://www.readbyqxmd.com/read/28738536/effect-of-apigenin-kaempferol-and-resveratrol-on-the-gene-expression-and-protein-secretion-of-tumor-necrosis-factor-alpha-tnf-%C3%AE-and-interleukin-10-il-10-in-raw-264-7-macrophages
#1
Marta Palacz-Wrobel, Paulina Borkowska, Monika Paul-Samojedny, Malgorzata Kowalczyk, Anna Fila-Danilow, Renata Suchanek-Raif, Jan Kowalski
Polyphenols such as apigenin, kaempferol or resveratrol are typically found in plants, including fruits, vegetables, herbs and spices, which have a wide range of biological functions such as antioxidative, anti-inflammatory, vasodilative, anticoagulative and proapoptotic. Discovering such multifunctional compounds in widely consumed plant-based products - ones that both inhibit the release of TNF-α from tissue macrophages and at the same time enhance the secretion of IL-10 - would be an important signpost in the quest for effective pharmacological treatment of numerous diseases that have an inflammatory etiology...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28734960/pharmacokinetic-interactions-of-curcuminoids-with-conventional-drugs-a-review
#2
REVIEW
Roodabeh Bahramsoltani, Roja Rahimi, Mohammad Hosein Farzaei
ETHNOPHARMACOLOGICAL RELEVANCE: Herb-drug interactions are of great concern in health practices. Curcumin is a natural polyphenol extracted from turmeric, a spice widely used all over the world. Curcumin is clinically used due to its acceptable safety profile and therapeutic efficacy. AIM OF THE STUDY: Current paper aims to highlight the effect of curcumin on concomitantly used drugs. METHODS: Electronic databases including PubMed, Scopus and Science Direct were searched with the keywords "curcumin" in the title/abstract and "drug interaction," "drug metabolism," "cytochrome," "P-glycoprotein" and "P450" in the whole text...
July 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28733192/pharmacological-evaluation-of-phytochemicals-from-south-indian-black-turmeric-curcuma-caesia-roxb-to-target-cancer-apoptosis
#3
K S Mukunthan, R S Satyan, T N Patel
Curcuma caesia Roxb. (Black turmeric), a perennial herb of the family Zingiberaceae is indigenous to India. C. caesia is used as a spice, food preservative and coloring agent commonly in the Indian subcontinent. Functional parametric pharmacological evaluations like drug ability and toxicity profile of this endangered species is poorly documented. In our present study, among all the extracts of dried C. caesia rhizome viz- hexane, ethyl acetate, methanol and water tested for free radical scavenging capacity by total antioxidant activity (TAO) method, Hexane Rhizome Extract (HRE) wzs found to possess remarkable activity (1200mg ascorbic acid equivalent/100g)...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28725631/biological-activities-and-medicinal-properties-of-asafoetida-a-review
#4
REVIEW
Augustine Amalraj, Sreeraj Gopi
Ferula asafoetida Linn. is a main source of asafoetida, a strong, tenacious and sulfurous odor, and oleo-gum resin of medicinal and nutritional importance. Asafoetida has been consumed as a spice and a folk medicine for centuries. Recent studies have shown several promising activities particularly relaxant, neuroprotective, memory enhancing, digestive enzyme, antioxidant, antispasmodic, hypotensive, hepatoprotective, antimicrobial, anticarcinogenic, anticancer, anticytotoxicity, antiobesity, anthelmintic and antagonistic effect...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725630/curcumin-an-age-old-anti-inflammatory-and-anti-neoplastic-agent
#5
REVIEW
Matthew C Fadus, Cecilia Lau, Jai Bikhchandani, Henry T Lynch
Curcumin is a natural anti-inflammatory agent that has been used for treating medical conditions for many years. Several experimental and pharmacologic trials have demonstrated its efficacy in the role as an anti-inflammatory agent. Curcumin has been shown to be effective in treating chronic conditions like rheumatoid arthritis, inflammatory bowel disease, Alzheimer's and common malignancies like colon, stomach, lung, breast, and skin cancers. As treatments in medicine become more and more complex, the answer may be something simpler...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28724763/species-specificity-of-vaccinia-virus-complement-control-protein-towards-bovine-classical-pathway-is-governed-primarily-by-direct-interaction-of-its-acidic-residues-with-factor-i
#6
Jitendra Kumar, Viveka Nand Yadav, Swastik Phulera, Ashish Kamble, Avneesh Kumar Gautam, Hemendra Singh Panwar, Arvind Sahu
Poxviruses display species tropism - variola virus is a human-specific virus, while vaccinia virus causes repeated outbreaks in dairy cattle. Consistent with this, variola virus complement regulator SPICE exhibit selectivity in inhibiting the human alternative complement pathway and vaccinia virus complement regulator VCP display selectivity in inhibiting the bovine alternative complement pathway. In the present study, we examined the species-specificity of VCP and SPICE towards the classical pathway (CP). We observed that VCP is ∼43-fold superior in inhibiting bovine CP than SPICE...
July 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28719925/acetylated-furostene-glycosides-from-solanum-gilo-fruits
#7
Edwige Nana Tchoupang, Christina Reder, Sylvin Benjamin Ateba, Martin Zehl, Hanspeter Kählig, Dieudonné Njamen, Franziska Höller, Sabine Glasl-Tazreiter, Liselotte Krenn
In continuation of our work on a traditional mixture of spices called "Nkui", used in Cameroon for its influence on women's reproductive health, we investigated the chemical composition of Solanum gilo, one component of "Nkui". A methanolic extract was studied in detail. After dereplication of several known compounds, two furo-5-stene-derived saponin glycosides with acetylated sugar moieties were isolated. By extensive 1- and 2D NMR experiments and HR-MS and GC-MS methods, the structures were elucidated as 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-O-α-L-rhamnopyranosyl-(1″→2')-β-D-glucopyranoside (A) and 26-[(3‴,4‴,6‴-tri-O-acetyl)-β-D-glucopyranosyloxy]-22-hydroxyfurost-5-en-3β-yl-[O-α-L-rhamnopyranosyl-(1''''→4')-O-α-L-rhamnopyranosyl-(1″→2')]-β-D-glucopyranoside (B), both new natural compounds...
July 18, 2017: Planta Medica
https://www.readbyqxmd.com/read/28708102/ability-of-soil-isolated-actinobacterial-strains-to-prevent-bind-and-biodegrade-ochratoxin-a
#8
Rachelle El Khoury, Florence Mathieu, Ali Atoui, Hiba Kawtharani, Anthony El Khoury, Charbel Afif, Richard G Maroun, André El Khoury
Ochratoxin A (OTA) is one of the most important mycotoxins, and contaminates several agricultural products, particularly cereals, grapes, maize, barley, spices and coffee. The aim of this project was to reduce the levels of OTA by supplementing the artificially contaminated solutions with seven strains of actinobacteria (AT10, AT8, SN7, MS1, ML5, G10 and PT1) in order to evaluate their capacity for binding and metabolizing the OTA, as well as their ability to reduce the expression of the genes responsible for its production in A...
July 14, 2017: Toxins
https://www.readbyqxmd.com/read/28702041/characterization-of-bip-genes-from-pepper-capsicum-annuum-l-and-the-role-of-cabip1-in-response-to-endoplasmic-reticulum-and-multiple-abiotic-stresses
#9
Hu Wang, Huanhuan Niu, Yufei Zhai, Minghui Lu
Adverse environmental conditions have a detrimental impact on crop growth and development, and cause protein denaturation or misfolding. The binding protein (BiP) plays an important protective role by alleviating endoplasmic reticulum (ER) stress induced by misfolded proteins. In this study, we characterized three BiP genes (CaBiP1, CaBiP2, and CaBiP3) in pepper, an economically important vegetable and spice species. The role of CaBiP1 in plant tolerance to ER stress and adverse environmental conditions (including heat, salinity, osmotic and drought stress) were investigated...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28701649/deodorizing-substance-in-black-cumin-nigella-sativa-l-seed-oil
#10
Toru Nakasugi, Takushi Murakawa, Koji Shibuya, Masanori Morimoto
A deodorizing substance in black cumin (Nigella sativa L.), a spice for curry and vegetable foods in Southwest Asia, was examined. The essential oil prepared from the seeds of this plant exhibited strong deodorizing activity against methyl mercaptan, which is a main factor in oral malodor. After purification with silica gel column chromatography, the active substance in black cumin seed oil was identified as thymoquinone. This monoterpenic quinone functions as the main deodorizing substance in this oil against methyl mercaptan...
July 12, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28700090/dietary-practices-and-fodmaps-in-south-asia-applicability-of-the-low-fodmap-diet-to-patients-with-irritable-bowel-syndrome
#11
REVIEW
Samapriya P Hewawasam, Marina Iacovou, Jane G Muir, Peter R Gibson
The low FODMAP diet has been described, evaluated and found efficacious for the treatment of patients with irritable bowel syndrome (IBS) primarily in Western countries. The aim of this review was to address the applicability of this diet to South Asia. The high prevalence of IBS in South Asia and its associated effects of quality of life and economics warrants the introduction of efficacious therapies. The considerable heterogeneity of dietary patterns and methods of food preparation across South Asian countries and a paucity of food analysis limit precision in defining foods that are high or low in FODMAPs...
July 12, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28695411/protective-effects-of-curcumin-against-rotenone-induced-rat-model-of-parkinson-s-disease-in-vivo-electrophysiological-and-behavioral-study
#12
L V Darbinyan, L E Hambardzumyan, K V Simonyan, V A Chavushyan, L P Manukyan, S A Badalyan, N Khalaji, V H Sarkisian
Curcumin is a naturally occurring phenolic yellow chemical isolated from the rhizomes of the plant Curcuma longa (turmeric), and is a major component of the spice turmeric. Curcumin has protective effects against rotenone-induced neural damage in Parkinson's disease (PD). The present study aims at providing new evidence for the validity of the rotenone rat model of PD by examining whether neuronal activity in the hippocampus is altered. Male albino rats were treated with rotenone injections (2.5 mg/ml intraperitoneally) for 21 days...
July 10, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28692848/modifications-of-fatty-acids-profile-lipid-peroxidation-and-antioxidant-capacity-in-raw-and-cooked-rabbit-burgers-added-with-ginger
#13
Simone Mancini, Giovanna Preziuso, Alessandro Dal Bosco, Valentina Roscini, Giuliana Parisi, Gisella Paci
Effects of ginger powder were evaluated on fatty acid (FA) profile, lipid peroxidation (TBARS) and antioxidant capacity (ABTS, DPPH and FRAP) of rabbit burgers. Burgers were manufactured as control samples (only meat) and two additions of ginger powder (1% and 2%) and stored raw at 4°C for 7days. At day 1, 4 and 7 of storage burgers were analysed both as raw and cooked. Ginger powder affected all the tested parameters; both PUFAω3 and PUFAω6 were incremented in raw and cooked samples leading to decreased atherogenicity and thrombogenicity indexes and increased hypo/hypercholesterolemic index and peroxidability index...
July 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28692429/synthetic-cannabinoids-the-hidden-side-of-spice-drugs
#14
Nicholas Pintori, Barbara Loi, Maddalena Mereu
Spice drugs are herbal mixtures sprayed with synthetic cannabinoids designed to mimic the psychoactive ingredient in marijuana [Δ-tetrahydrocannabinol (Δ-THC)] and synthesized by introducing modifications to the chemical structure of parental compounds aiming to circumvent legal regulations. Synthetic cannabinoid use/abuse can be devastating as toxicological effects and adverse reactions cannot be entirely predicted and may vary with the dose, route of administration, individual vulnerability and concomitant intake with other drugs...
July 7, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28689138/enhanced-dna-double-strand-break-repair-of-microbeam-targeted-a549-lung-carcinoma-cells-by-adjacent-wi38-normal-lung-fibroblast-cells-via-bi-directional-signaling
#15
Alisa Kobayashi, Tengku Ahbrizal Farizal Tengku Ahmad, Narongchai Autsavapromporn, Masakazu Oikawa, Shino Homma-Takeda, Yoshiya Furusawa, Jun Wang, Teruaki Konishi
Understanding the mechanisms underlying the radiation-induced bystander effect (RIBE) and bi-directional signaling between irradiated carcinoma cells and their surrounding non-irradiated normal cells is relevant to cancer radiotherapy. The present study investigated propagation of RIBE signals between human lung carcinoma A549 cells and normal lung fibroblast WI38 cells in bystander cells, either directly or indirectly contacting irradiated A549 cells. We prepared A549-GFP/WI38 co-cultures and A549-GFP/A549 co-cultures, in which A549-GFP cells stably expressing H2BGFP were co-cultured with either A549 cells or WI38 cells, respectively...
June 23, 2017: Mutation Research
https://www.readbyqxmd.com/read/28680454/piperine-enhances-carbohydrate-fat-metabolism-in-skeletal-muscle-during-acute-exercise-in-mice
#16
Jisu Kim, Kang-Pa Lee, Dae-Won Lee, Kiwon Lim
BACKGROUND: Exercise promotes energy metabolism (e.g., metabolism of glucose and lipids) in skeletal muscles; however, reactive oxygen species are also generated during exercise. Various spices have been reported to have beneficial effects in sports medicine. Here, we investigated the effects of piperine, an active compound in black pepper, to determine its effects on metabolism during acute endurance exercise. METHODS: ICR mice (n = 18) were divided into three groups: nonexercise (CON), exercise (EX), and exercise with piperine (5 mg/kg) treatment (EP)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28679846/curcumin-mediates-anticancer-effects-by-modulating-multiple-cell-signaling-pathways
#17
REVIEW
Ajaikumar B Kunnumakkara, Devivasha Bordoloi, Choudhary Harsha, Kishore Banik, Subash C Gupta, Bharat B Aggarwal
Curcumin, a component of a spice native to India, was first isolated in 1815 by Vogel and Pelletier from the rhizomes of Curcuma longa (turmeric) and, subsequently, the chemical structure of curcumin as diferuloylmethane was reported by Milobedzka et al. [(1910) 43., 2163-2170]. Since then, this polyphenol has been shown to exhibit antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antifungal activities. The current review primarily focuses on the anticancer potential of curcumin through the modulation of multiple cell signaling pathways...
August 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28678344/prebiotic-potential-and-chemical-composition-of-seven-culinary-spice-extracts
#18
Qing-Yi Lu, Paula H Summanen, Ru-Po Lee, Jianjun Huang, Susanne M Henning, David Heber, Sydney M Finegold, Zhaoping Li
The objective of this study was to investigate prebiotic potential, chemical composition, and antioxidant capacity of spice extracts. Seven culinary spices including black pepper, cayenne pepper, cinnamon, ginger, Mediterranean oregano, rosemary, and turmeric were extracted with boiling water. Major chemical constituents were characterized by RP-HPLC-DAD method and antioxidant capacity was determined by measuring colorimetrically the extent to scavenge ABTS radical cations. Effects of spice extracts on the viability of 88 anaerobic and facultative isolates from intestinal microbiota were determined by using Brucella agar plates containing serial dilutions of extracts...
July 5, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28671272/the-effects-of-different-spices-and-fat-types-on-the-formation-of-heterocyclic-aromatic-amines-in-barbecued-sucuk
#19
Kübra Ünal, Mustafa Karakaya, Fatih Öz
BACKGROUND: Sucuk is one of the popular traditional Turkish meat products. The aim of this research was to evaluate the effects of different spices (clove, 0.2%; cinnamon, 0.5%) and animal fat types (beef fat, tallow, subcutaneous and tail fat) on the formation of heterocyclic aromatic amine (HCA) in barbecued sucuk. RESULTS: While 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) could not be detected in the any of the samples, 2-amino-3-methylimidazo[4,5-f]quinoxaline (IQx) (up to 0...
July 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28668480/a-new-challenge-in-forensic-toxicology-exemplified-by-a-case-of-murder-under-the-influence-of-a-synthetic-cannabinoid-am-2201
#20
Sebastian Rojek, Małgorzata Kłys, Martyna Maciów-Głąb, Karol Kula
Among new psychoactive substances (NPS) available on the narcotic market, a significant number consists of synthetic cannabinoids commonly known as smokable herbal "spice" and "K2", and which are legally treated as a legal alternative to marijuana. The dearth of information on the pharmacology of these intoxicants as they are introduced into the market has created the urgent need among healthcare providers for case studies on the substances belonging to this group, both in terms of the consequences of using such intoxicants, and in methods of detection...
June 24, 2017: Legal Medicine
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