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https://www.readbyqxmd.com/read/29134131/medicinally-important-aromatic-plants-with-radioprotective-activity
#1
REVIEW
Ravindra M Samarth, Meenakshi Samarth, Yoshihisa Matsumoto
Aromatic plants are often used as natural medicines because of their remedial and inherent pharmacological properties. Looking into natural resources, particularly products of plant origin, has become an exciting area of research in drug discovery and development. Aromatic plants are mainly exploited for essential oil extraction for applications in industries, for example, in cosmetics, flavoring and fragrance, spices, pesticides, repellents and herbal beverages. Although several medicinal plants have been studied to treat various conventional ailments only a handful studies are available on aromatic plants, especially for radioprotection...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29129665/intravasation-of-sw620-colon-cancer-cell-spheroids-through-the-blood-endothelial-barrier-is-inhibited-by-clinical-drugs-and-flavonoids-in-vitro
#2
Silvio Holzner, Stefan Brenner, Atanas Georgiev Atanasov, Daniel Senfter, Serena Stadler, Chi Huu Nguyen, Adryan Fristiohady, Daniela Milovanovic, Nicole Huttary, Sigurd Krieger, Zsuzsanna Bago-Horvath, Oliver de Wever, Ioannis Tentes, Ali Özmen, Walter Jäger, Helmut Dolznig, Verena Maria Dirsch, Robert Michael Mader, Liselotte Krenn, Georg Krupitza
Mechanisms how colorectal cancer (CRC) cells penetrate blood micro-vessel endothelia and metastasise is poorly understood. To study blood endothelial cell (BEC) barrier breaching by CRC emboli, an in vitro assay measuring BEC-free areas underneath SW620 cell spheroids, so called "circular chemorepellent induced defects" (CCIDs, appearing in consequence of endothelial retraction), was adapted and supported by Western blotting, EIA-, EROD- and luciferase reporter assays. Inhibition of ALOX12 or NF-κB in SW620 cells or BECs, respectively, caused attenuation of CCIDs...
November 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29129385/effect-directed-fingerprints-of-77-botanical-extracts-via-a-generic-high-performance-thin-layer-chromatography-method-combined-with-assays-and-mass-spectrometry
#3
S Krüger, L Hüsken, R Fornasari, I Scainelli, G E Morlock
Quantitative effect-directed profiles of 77 industrially and freshly extracted botanicals like herbs, spices, vegetables and fruits, widely used as food ingredients, dietary supplements or traditional medicine, gave relevant information on their quality. It allows the assessment of food, dietary supplements and phytomedicines with regard to potential health-promoting activities. In contrary to sum parameter assays and targeted analysis, chromatography combined with effect-directed analysis allows fast assignment of single active compounds and evaluation of their contribution to the overall activity, originating from a food or botanical sample...
October 29, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29127646/can-we-spice-up-our-christmas-dinner-busting-the-myth-of-the-chinese-restaurant-syndrome
#4
N W E van den Berg, J Neefs, W R Berger, S W E Baalman, E Meulendijks, M Kawasaki, E M Kemper, F R Piersma, M W Veldkamp, R Wesselink, S P J Krul, J R de Groot
BACKGROUND: Monosodium glutamate (MSG), also referred to as Vetsin or E621, is a flavour enhancer frequently used in Asian cuisine and abundantly present in the famous Chinese dish Peking duck. MSG is notorious for triggering the onset of the so-called 'Chinese restaurant syndrome' (CRS), a complex of unpleasant symptoms, which might include flushing, sweating and the onset of atrial fibrillation (AF). This study aims to determine the effects of MSG on the occurrence of AF. METHODS: We conducted a placebo self-controlled single-arm study in the Academic Medical Centre in Amsterdam...
November 10, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29119099/wnt-and-hedgehog-signaling-regulate-the-differentiation-of-f9-cells-into-extraembryonic-endoderm
#5
Gurjoth S J Deol, Tina N Cuthbert, Mohamed I Gatie, Danielle M Spice, Lindsay R Hilton, Gregory M Kelly
Mouse F9 cells differentiate into primitive extraembryonic endoderm (PrE) when treated with retinoic acid (RA), and this is accompanied by an up-regulation of Gata6. The role of the GATA6 network in PrE differentiation is known, and we have shown it directly activates Wnt6. Canonical Wnt/β-catenin signaling is required by F9 cells to differentiate to PrE, and this, like most developmental processes, requires input from one or more additional pathways. We found both RA and Gata6 overexpression, can induce the expression of Indian Hedgehog (Ihh) and a subset of its target genes through Gli activation during PrE induction...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/29117507/zingerone-protects-keratinocyte-stem-cells-from-uvb-induced-damage
#6
Jienny Lee, Sae Woong Oh, Seoung Woo Shin, Kyung-Woo Lee, Jae-Youl Cho, Jongsung Lee
The epidermis, the outermost layer of the skin, is a stratified epithelium that protects the body from the external environment. Keratinocyte stem cells (KSCs) are involved in epidermis homeostasis by maintaining epidermal integrity through a process of constant regeneration. Ultraviolet B (UVB) radiation is a major inducer of cellular damage in the epidermis. In this study, we investigated the effects of zingerone (a phenolic compound derived from spices) on UVB-induced cellular damage in KSCs. We found that zingerone significantly inhibited cellular senescence of KSCs in response to UVB irradiation...
November 5, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29108570/liquid-chromatography-electrochemical-detection-for-the-determination-of-ethoxyquin-and-its-dimer-in-pear-skin-and-salmon-samples
#7
R Rodríguez-Gómez, Marie Vandeput, A Zafra-Gómez, Jean-Michel Kauffmann
Ethoxyquin (EQ) is widely used as a synthetic antioxidant in animal feed, an antiscalding agent in apples and pears and as a color preservative in some spices. Since the presence of EQ in food products could cause negative health effects it is necessary to develop reliable analytical methods to evaluate the risk of human exposure. In this work, a sensitive, selective and accurate method based on solid-liquid extraction followed by clean-up with solid sorbent and liquid chromatography-electrochemical detection analysis with boron doped diamond electrode (LC-EC) for the determination of ethoxyquin and its dimer (EQDM) in pear skin and salmon samples, was developed...
January 15, 2018: Talanta
https://www.readbyqxmd.com/read/29104647/anti-inflammatory-effects-of-water-extract-from-bell-pepper-capsicum-annuum-l-var-grossum-leaves-in-vitro
#8
Mai Hazekawa, Yuko Hideshima, Kazuhiko Ono, Takuya Nishinakagawa, Tomoyo Kawakubo-Yasukochi, Tomoka Takatani-Nakase, Manabu Nakashima
Fruits and vegetables have been recognized as natural sources of various bioactive compounds. Peppers, one such natural source, are consumed worldwide as spice crops. They additionally have an important role in traditional medicine, as a result of their antioxidant bioactivity via radical scavenging. However, there are no reports regarding the bioactivity of the bell pepper (Capsicum annuum L. var. grossum), a commonly used edible vegetable. The present study aimed to evaluate the anti-inflammatory effect of water extract from bell pepper leaves on mouse spleen cells, and explore the potential mechanism underlying this effect...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29097552/the-anti-inflammatory-activity-of-curcumin-is-mediated-by-its-oxidative-metabolites
#9
Rebecca L Edwards, Paula B Luis, Paolo V Varuzza, Akil I Joseph, Sai Han Presley, Rupesh Chaturvedi, Claus Schneider
The spice turmeric, with its active polyphenol curcumin, has been used as anti-inflammatory remedy in traditional Asian medicine for centuries. Many cellular targets of curcumin have been identified, but how such a wide range of targets can be affected by a single compound is unclear. Here, we identified curcumin as a pro-drug that requires oxidative activation into reactive metabolites to exert anti-inflammatory activities. Synthetic curcumin analogs that undergo oxidative transformation potently inhibited the proinflammatory transcription factor nuclear factor kappa B (NF-κB), whereas stable, nonoxidizable analogs were less active, with a correlation coefficient (R(2)) of IC50 versus log of autoxidation rate of 0...
November 2, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29094243/alleviation-of-cardiac-damage-by-dietary-fenugreek-trigonella-foenum-graecum-seeds-is-potentiated-by-onion-allium-cepa-in-experimental-diabetic-rats-via-blocking-renin-angiotensin-system
#10
Seetur R Pradeep, Krishnapura Srinivasan
Hyperglycemia is one of the metabolic and homeostatic abnormalities that increase the cardiovascular mortality in diabetic patients by increased oxidative stress. We have recently reported amelioration of oxidative stress in cardiac tissue by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats. The mechanistic aspects of the cardio-protective influence of dietary fenugreek seeds (10%) and onion (3% powder) both individually and in combination on hyperglycemia-mediated cardiac damage was further investigated in this study on streptozotocin-induced diabetic rats...
November 1, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29090120/magnesium-stearate-a-widely-used-food-additive-exhibits-a-lack-of-in-vitro-and-in-vivo-genotoxic-potential
#11
Cheryl A Hobbs, Kazuhiko Saigo, Mihoko Koyanagi, Shim-Mo Hayashi
Magnesium stearate is widely used in the production of dietary supplement and pharmaceutical tablets, capsules and powders as well as many food products, including a variety of confectionery, spices and baking ingredients. Although considered to have a safe toxicity profile, there is no available information regarding its potential to induce genetic toxicity. To aid safety assessment efforts, magnesium sulfate was evaluated in a battery of tests including a bacterial reverse mutation assay, an in vitro chromosome aberration assay, and an in vivo erythrocyte micronucleus assay...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29089370/enjoyment-of-spicy-flavor-enhances-central-salty-taste-perception-and-reduces-salt-intake-and-blood-pressure
#12
Qiang Li, Yuanting Cui, Rongbing Jin, Hongmei Lang, Hao Yu, Fang Sun, Chengkang He, Tianyi Ma, Yingsha Li, Xunmei Zhou, Daoyan Liu, Hongbo Jia, Xiaowei Chen, Zhiming Zhu
High salt intake is a major risk factor for hypertension and is associated with cardiovascular events. Most countries exhibit a traditionally high salt intake; thus, identification of an optimal strategy for salt reduction at the population level may have a major impact on public health. In this multicenter, random-order, double-blind observational and interventional study, subjects with a high spice preference had a lower salt intake and blood pressure than subjects who disliked spicy food. The enjoyment of spicy flavor enhanced salt sensitivity and reduced salt preference...
October 31, 2017: Hypertension
https://www.readbyqxmd.com/read/29089369/how-to-reduce-dietary-salt-intake-just-add-spice
#13
EDITORIAL
Richard David Wainford
No abstract text is available yet for this article.
December 2017: Hypertension
https://www.readbyqxmd.com/read/29081890/role-of-diet-and-nutritional-supplements-in-parkinson-s-disease-progression
#14
Laurie K Mischley, Richard C Lau, Rachel D Bennett
OBJECTIVES: The goal of this study is to describe modifiable lifestyle variables associated with reduced rate of Parkinson's disease (PD) progression. METHODS: The patient-reported outcomes in PD (PRO-PD) were used as the primary outcome measure, and a food frequency questionnaire (FFQ) was used to assess dietary intake. In this cross-sectional analysis, regression analysis was performed on baseline data to identify the nutritional and pharmacological interventions associated with the rate of PD progression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29080464/curcumin-and-endometriosis-review-on-potential-roles-and-molecular-mechanisms
#15
REVIEW
Tahereh Arablou, Roya Kolahdouz-Mohammadi
Endometriosis, an estrogen-dependent inflammatory disease, is one of the most common chronic gynecological disorders affecting women in reproductive age. It is characterized by the presence of endometrial-like tissue outside the uterus. The exact pathophysiology of endometriosis is not still well-known, but the immune system and inflammation have been considered as pivotal factors in disease progression. Turmeric, an important spice all around the world, is obtained from the rhizomes of Curcuma longa, a member of the Zingiberaceae family...
October 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29079990/the-effects-of-synbiotic-supplementation-on-carotid-intima-media-thickness-biomarkers-of-inflammation-and-oxidative-stress-in-people-with-overweight-diabetes-and-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#16
Alireza Farrokhian, Fariba Raygan, Ali Soltani, Maryam Tajabadi-Ebrahimi, Mehran Sharifi Esfahani, Ali Akbar Karami, Zatollah Asemi
Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85 years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 10(9) CFU/g each) plus 800 mg inulin or placebo (n = 30 each group) for 12 weeks...
October 27, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29075628/selective-essential-oils-from-spice-or-culinary-herbs-have-high-activity-against-stationary-phase-and-biofilm-borrelia-burgdorferi
#17
Jie Feng, Shuo Zhang, Wanliang Shi, Nevena Zubcevik, Judith Miklossy, Ying Zhang
Although the majority of patients with acute Lyme disease can be cured with the standard 2-4 week antibiotic treatment, about 10-20% of patients continue suffering from chronic symptoms described as posttreatment Lyme disease syndrome. While the cause for this is debated, one possibility is that persister bacteria are not killed by the current Lyme antibiotics and remain active in the system. It has been reported that essential oils have antimicrobial activities and some have been used by patients with persisting Lyme disease symptoms...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29073462/implementing-early-mobilisation-in-the-intensive-care-unit-an-integrative-review
#18
REVIEW
Sonja Phelan, Frances Lin, Marion Mitchell, Wendy Chaboyer
BACKGROUND: The intensive care unit provides complex care for critically ill patients. Consequently, due to the nature of critical illness and the therapies administered in intensive care, patients are often on prolonged periods of bed rest with limited mobility. It has been recognised that mobilising critically ill patients is beneficial to patients' recovery, however implementing early mobility as a standard of care remains challenging in practice. OBJECTIVES: To identify the key factors that underpin successful implementation and sustainability of early mobilisation in adult intensive care units...
October 2, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29070093/properties-and-aromatic-profile-of-dry-fermented-sausages-produced-from-kr%C3%A5-kopolje-pigs-reared-under-organic-and-conventional-rearing-regime
#19
M Škrlep, M Čandek-Potokar, U Tomažin, N Batorek Lukač, M Flores
Krškopolje pig, the only Slovenian autochtonous breed is still relatively untapped, with almost no information available on the effect of rearing conditions or its aptitude for processing and meat product quality. In the present study, dry-fermented sausages were produced from Krškopolje pigs that were fed similar diets (with regard to ingredients, energy and protein content) but reared in either conventional (CON) or organic conditions (ECO). Sausage weight losses at the end of processing were recorded and their final pH, chemical composition (moisture, fat and protein content, proteolysis index, fat and protein oxidation, fatty acid and free fatty acid profile) were determined in addition to measurements of instrumental texture, sensory evaluation and volatile profile analysis...
October 26, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29067730/simultaneous-qsm-and-metabolic-imaging-of-the-brain-using-spice
#20
Xi Peng, Fan Lam, Yudu Li, Bryan Clifford, Zhi-Pei Liang
PURPOSE: To map brain metabolites and tissue magnetic susceptibility simultaneously using a single three-dimensional (1) H-MRSI acquisition without water suppression. METHODS: The proposed technique builds on a subspace imaging method called spectroscopic imaging by exploiting spatiospectral correlation (SPICE), which enables ultrashort echo time (TE)/short pulse repetition time (TR) acquisitions for (1) H-MRSI without water suppression. This data acquisition scheme simultaneously captures both the spectral information of brain metabolites and the phase information of the water signals that is directly related to tissue magnetic susceptibility variations...
October 24, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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