Mahboob Rahman, Sara Pressel, Barry R Davis, Chuke Nwachuku, Jackson T Wright, Paul K Whelton, Joshua Barzilay, Vecihi Batuman, John H Eckfeldt, Michael A Farber, Stanley Franklin, Mario Henriquez, Nelson Kopyt, Gail T Louis, Mohammad Saklayen, Carole Stanford, Candace Walworth, Harry Ward, Thomas Wiegmann
BACKGROUND: Chronic kidney disease is common in older patients with hypertension. OBJECTIVE: To compare rates of coronary heart disease (CHD) and end-stage renal disease (ESRD) events; to determine whether glomerular filtration rate (GFR) independently predicts risk for CHD; and to report the efficacy of first-step treatment with a calcium-channel blocker (amlodipine) or an angiotensin-converting enzyme inhibitor (lisinopril), each compared with a diuretic (chlorthalidone), in modifying cardiovascular disease (CVD) outcomes in high-risk patients with hypertension stratified by GFR...
February 7, 2006: Annals of Internal Medicine