keyword
MENU ▼
Read by QxMD icon Read
search

Giovannini Marc

keyword
https://www.readbyqxmd.com/read/27576181/endoscopic-ultrasound-guided-needle-based-confocal-laser-endomicroscopy-in-solid-pancreatic-masses
#1
Marc Giovannini, Fabrice Caillol, Geneviève Monges, Flora Poizat, Anne-Isabelle Lemaistre, Bertrand Pujol, Damien Lucidarme, Laurent Palazzo, Bertrand Napoléon
BACKGROUND AND STUDY AIMS: The differential diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is currently suboptimal in centers that are not equipped with rapid on-site evaluation. Needle-based confocal laser endomicroscopy (nCLE) enables real-time in vivo microscopic imaging during endoscopy. This study aimed to describe nCLE interpretation criteria for the characterization of pancreatic masses, with histopathological correlation, and to perform the first validation of these criteria...
October 2016: Endoscopy
https://www.readbyqxmd.com/read/27462772/a-pancreatic-ductal-adenocarcinoma-subpopulation-is-sensitive-to-fk866-an-inhibitor-of-nampt
#2
Marine Barraud, Jonathan Garnier, Celine Loncle, Odile Gayet, Charlotte Lequeue, Sophie Vasseur, Benjamin Bian, Pauline Duconseil, Marine Gilabert, Martin Bigonnet, Aurélie Maignan, Vincent Moutardier, Stephane Garcia, Olivier Turrini, Jean-Robert Delpero, Marc Giovannini, Philippe Grandval, Mohamed Gasmi, Mehdi Ouaissi, Veronique Secq, Flora Poizat, Nicolas Guibert, Juan Iovanna, Nelson Dusetti
Treating pancreatic cancer is extremely challenging due to multiple factors, including chemoresistance and poor disease prognosis. Chemoresistance can be explained by: the presence of a dense stromal barrier leading to a lower vascularized condition, therefore limiting drug delivery; the huge intra-tumoral heterogeneity; and the status of epithelial-to-mesenchymal transition. These factors are highly variable between patients making it difficult to predict responses to chemotherapy. Nicotinamide phosphoribosyl transferase (NAMPT) is the main enzyme responsible for recycling cytosolic NAD+ in hypoxic conditions...
July 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/27460387/eus-guided-pancreatic-drainage-for-pancreatic-strictures-after-failed-ercp-a-multicenter-international-collaborative-study
#3
Amy Tyberg, Reem Z Sharaiha, Prashant Kedia, Nikhil Kumta, Monica Gaidhane, Everson Artifon, Marc Giovannini, Michel Kahaleh
BACKGROUND AND AIMS: Endoscopic retrograde pancreatography (ERP) is considered first-line therapy for management of symptomatic pancreatic duct obstruction. Technical failure with ERP occurs when the main pancreatic duct cannot be cannulated. EUS-guided drainage of the pancreatic duct is a minimally invasive alternative to surgery for failed conventional ERP. We present an international, multicenter study on the safety and efficacy of EUS-guided pancreatic drainage (EUS-PD) for patients who fail conventional endoscopic therapy...
July 25, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27409435/improving-the-axial-and-lateral-resolution-of-three-dimensional-fluorescence-microscopy-using-random-speckle-illuminations
#4
Awoke Negash, Simon Labouesse, Nicolas Sandeau, Marc Allain, Hugues Giovannini, Jérôme Idier, Rainer Heintzmann, Patrick C Chaumet, Kamal Belkebir, Anne Sentenac
We consider a fluorescence microscope in which several three-dimensional images of a sample are recorded for different speckle illuminations. We show, on synthetic data, that by summing the positive deconvolution of each speckle image, one obtains a sample reconstruction with axial and transverse resolutions that compare favorably to that of an ideal confocal microscope.
June 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/27328985/international-collaborative-study-on-eus-guided-gallbladder-drainage-are-we-ready-for-prime-time
#5
Michel Kahaleh, Manuel Perez-Miranda, Everson L Artifon, Reem Z Sharaiha, Prashant Kedia, Irene Peñas, Carlos De la Serna, Nikhil A Kumta, Fernando Marson, Monica Gaidhane, Christine Boumitri, Viviana Parra, Carlos M Rondon Clavo, Marc Giovannini
BACKGROUND: Cholecystectomy remains the gold standard treatment of cholecystitis. Endoscopic treatment of cholecystitis includes transpapillary gallbladder drainage. Recently, endoscopic ultrasound-guided transmural drainage of the gallbladder (EUS-GBD) has been reported. This study reports the cumulative experience of an international group performing EUS-GBD. METHODS: Cases of EUS-GBD from January 2012 to November 2013 from 3 tertiary-care institutions were captured in a registry...
September 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27299638/papillary-cannulation-and-sphincterotomy-techniques-at-ercp-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline
#6
Pier Alberto Testoni, Alberto Mariani, Lars Aabakken, Marianna Arvanitakis, Erwan Bories, Guido Costamagna, Jacques Devière, Mario Dinis-Ribeiro, Jean-Marc Dumonceau, Marc Giovannini, Tibor Gyokeres, Michael Hafner, Jorma Halttunen, Cesare Hassan, Luis Lopes, Ioannis S Papanikolaou, Tony C Tham, Andrea Tringali, Jeanin van Hooft, Earl J Williams
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It provides practical advice on how to achieve successful cannulation and sphincterotomy at minimum risk to the patient. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to define the strength of recommendations and the quality of evidence. Main recommendations 1 ESGE suggests that difficult biliary cannulation is defined by the presence of one or more of the following: more than 5 contacts with the papilla whilst attempting to cannulate; more than 5 minutes spent attempting to cannulate following visualization of the papilla; more than one unintended pancreatic duct cannulation or opacification (low quality evidence, weak recommendation)...
July 2016: Endoscopy
https://www.readbyqxmd.com/read/27286454/heterogeneity-of-metastatic-pancreatic-adenocarcinoma-lung-metastasis-show-better-prognosis-than-liver-metastasis-a-case-control-study
#7
Claire Decoster, Marine Gilabert, Aurélie Autret, Olivier Turrini, Sandrine Oziel-Taieb, Flora Poizat, Marc Giovannini, Patrice Viens, Juan Iovanna, Jean-Luc Raoul
The prognosis of metastatic pancreatic ductal adenocarcinoma (PDAC) is grim, with a median overall survival of under 1 year. In our clinical practice, we observed a few cases of isolated lung metastases from PDAC with unusually long outcomes. We compared these cases in a case-control study of lung-only vs. liver-only metastases from PDAC.From our database, we found 37 cases of lung-only metastases and paired them with 37 cases of liver-only metastases by age, tumor location and treatment.The lung-only group differed significantly from the liver-only group with respect to the following parameters: female predominance, more metachronous cases, fewer nodules per patient, and smaller increases in tumor markers...
6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27230854/xpr1-mutations-are-a-rare-cause-of-primary-familial-brain-calcification
#8
Mathieu Anheim, Uriel López-Sánchez, Donatella Giovannini, Anne-Claire Richard, Jawida Touhami, Ludovic N'Guyen, Gabrielle Rudolf, Anne Thibault-Stoll, Thierry Frebourg, Didier Hannequin, Dominique Campion, Jean-Luc Battini, Marc Sitbon, Gaël Nicolas
Mutations in XPR1, a gene encoding an inorganic phosphate exporter, have recently been identified in patients with primary familial brain calcification (PFBC). Using Sanger sequencing, we screened XPR1 in 18 unrelated patients with PFBC and no SLC20A2, PDGFB, or PDGFRB mutation. XPR1 variants were tested in an in vitro physiological complementation assay and patient blood cells were assessed ex vivo for phosphate export. We identified a novel c.260T > C, p.(Leu87Pro) XPR1 variant in a 41-year-old man complaining of micrographia and dysarthria and demonstrating mild parkinsonism, cerebellar ataxia and executive dysfunction...
August 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27157448/frey-syndrome
#9
Sibylle Blanc, Thierry Bourrier, Franck Boralevi, Dominique Sabouraud-Leclerc, Nhân Pham-Thi, Laure Couderc, Antoine Deschildre, Guy Dutau, Marc Albertini, Antoine Tran, Lisa Giovannini-Chami
OBJECTIVE: To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood. STUDY DESIGN: A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests. RESULTS: Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral...
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27129553/neoplastic-barrett-s-oesophagus-and-long-term-follow-up-after-endoscopic-therapy-complete-histological-eradication-of-barrett-associated-with-high-grade-dysplasia-significantly-decreases-neoplasia-relapse
#10
Fabrice Caillol, Sebastien Godat, Aurelie Autret, Erwan Bories, Christian Pesenti, Jean Phillippe Ratone, Flora Poizat, Jerome Guiramand, Jean Robert Delpero, Marc Giovannini
BACKGROUND AND AIMS: Endotherapy (ET) has replaced surgery as the first-line treatment of high-grade dysplasia (HGD)/superficial ECA (ECAs) from Barrett's oesophagus (BO). However, long-term follow-up and predictive factors of relapse are not so well studied. The aim of the following study was to evaluate the efficiency of ET for treatment of HGD/ECAs and to determine factors of long-term efficiency. METHODS: ET procedures were manually reported and registered in a hospital data base from March 2000 to July 2010...
December 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27107061/expression-of-genes-with-copy-number-alterations-and-survival-of-patients-with-pancreatic-adenocarcinoma
#11
David J Birnbaum, François Bertucci, Pascal Finetti, José Adélaïde, Marc Giovannini, Olivier Turrini, Jean Robert Delpero, Jean Luc Raoul, Max Chaffanet, Vincent Moutardier, Daniel Birnbaum, Emilie Mamessier
BACKGROUND/AIM: Individual molecular information might improve management of pancreatic adenocarcinoma. To identify actionable genes, at the transcriptional level, we investigated candidate genes that we had previously identified using array-comparative genomic hybridization (aCGH). MATERIALS AND METHODS: We collected 10 public gene-expression datasets, gathering a total of 524 pancreatic samples (105 normal and 419 malignant tissues). Based on our previous aCGH analysis, we searched for genes differentially expressed between normal and malignant samples and genes associated with survival...
May 2016: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/27087954/efficiency-and-safety-of-endoscopic-resection-in-the-management-of-subepithelial-lesions-of-the-stomach
#12
Sébastien Godat, Maxime Robert, Fabrice Caillol, Erwan Bories, Christian Pesenti, Chiara De Cassan, Jean Philippe Ratone, Flora Poizat, Marc Giovannini
BACKGROUND: Gastric subepithelial tumors represent a diagnostic and therapeutic challenge, given their histologic heterogeneity and potential malignant behavior. OBJECTIVE: The objective of this article is to evaluate the interest, efficiency and safety of endoscopic resection for subepithelial gastric lesions of size <20 mm. METHODS: We conducted a single-center retrospective study in a tertiary care center. RESULTS: A total of 33 lesions (10 malignant/23 benign lesions) were studied...
April 2016: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26949002/probe-based-confocal-laser-endomicroscopy-for-the-differential-diagnosis-of-gastric-tubular-adenoma-and-intestinal-metaplasia-in-a-patient-with-severe-atrophic-pangastritis
#13
Elisa Ryoka Baba, Adriana Vaz Safatle-Ribeiro, Gabriela Ferreira Paduani, Marc Giovannini, Fauze Maluf-Filho
No abstract text is available yet for this article.
July 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26855537/endoscopic-ultrasonography-transition-towards-the-future-of-gastro-intestinal-diseases
#14
REVIEW
Stefania De Lisi, Marc Giovannini
Endoscopic ultrasonography (EUS) is a technique with an established role in the diagnosis and staging of gastro-intestinal tumors. In recent years, the spread of new devices dedicated to tissue sampling has improved the diagnostic accuracy of EUS fine-needle aspiration. The development of EUS-guided drainage of the bilio-pancreatic region and abdominal fluid collections has allowed EUS to evolve into an interventional tool that can replace more invasive procedures. Emerging techniques applying EUS in pancreatic cancer treatment and in celiac neurolysis have been described...
February 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26716396/eosinophilic-pneumonias-in-children-a-review-of-the-epidemiology-diagnosis-and-treatment
#15
REVIEW
Lisa Giovannini-Chami, Sibylle Blanc, Alice Hadchouel, André Baruchel, Rachida Boukari, Jean-Christophe Dubus, Michael Fayon, Muriel Le Bourgeois, Nadia Nathan, Marc Albertini, Annick Clément, Jacques de Blic
Pediatric eosinophilic pneumonias (EPs) are characterized by a significant infiltration of the alveolar spaces and lung interstitium by eosinophils, with conservation of the lung structure. In developed countries, EPs constitute exceptional entities in pediatric care. Clinical symptoms may be transient (Löffler syndrome), acute (<1 month and mostly <7 days), or chronic (>1 month). Diagnosis relies on demonstration of alveolar eosinophilia on bronchoalveolar lavage, whether or not associated with blood eosinophilia...
February 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26699808/international-association-of-pancreatology-iap-european-pancreatic-club-epc-consensus-review-of-guidelines-for-the-treatment-of-pancreatic-cancer
#16
REVIEW
Kyoichi Takaori, Claudio Bassi, Andrew Biankin, Thomas B Brunner, Ivana Cataldo, Fiona Campbell, David Cunningham, Massimo Falconi, Adam E Frampton, Junji Furuse, Marc Giovannini, Richard Jackson, Akira Nakamura, William Nealon, John P Neoptolemos, Francisco X Real, Aldo Scarpa, Francesco Sclafani, John A Windsor, Koji Yamaguchi, Christopher Wolfgang, Colin D Johnson
BACKGROUND: Pancreatic cancer is one of the most devastating diseases with an extremely high mortality. Medical organizations and scientific societies have published a number of guidelines to address active treatment of pancreatic cancer. The aim of this consensus review was to identify where there is agreement or disagreement among the existing guidelines and to help define the gaps for future studies. METHODS: A panel of expert pancreatologists gathered at the 46th European Pancreatic Club Meeting combined with the 18th International Association of Pancreatology Meeting and collaborated on critical reviews of eight English language guidelines for the clinical management of pancreatic cancer...
January 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/26643694/needle-based-confocal-laser-endomicroscopy
#17
Marc Giovannini
New applications of confocal laser endomicroscopy were developed as pCLE in the bile duct and nCLE for pancreatic cystic tumors, pancreatic masses and lymph nodes. The aim of this paper would be to give you an update in this new technology and to try to define its place in the diagnosis of cystic and solid pancreatic masses. The material used was a 19G EUS-needle in which the stylet was replaced by the Confocal mini-probe. The mini-probe (0.632 mm of diameter) is pre-loaded and screwed by a locking device in the EUS-Needle and guided endosonographically in the target...
October 2015: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/26545612/treatment-of-pancreatic-adenocarcinoma-in-elderly-patients-over-75-years-of-age-a-retrospective-series-of-129-patients
#18
Sandrine Oziel-Taieb, Marjorie Faure, Marine Gilabert, Aurélie Autret, Olivier Turrini, Laurence Moureau-Zabotto, Marc Giovannini, Frederique Rousseau, Jean-Luc Raoul
PURPOSE: To better know the presentation and outcome of pancreatic adenocarcinoma in patients above 75 years of age. METHOD: Retrospective analysis of consecutive patients with a pancreatic adenocarcinoma seen in the Comprehensive Cancer Center of Marseille between January 2002 and January 2012 was used. RESULTS: During these 10 years, 129 patients older than 75 years of age were seen, 61 females and 68 males, median age 78. At diagnosis, the tumor was metastatic in 45%...
March 2016: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/26428198/in-vivo-characterization-of-pancreatic-cystic-lesions-by-needle-based-confocal-laser-endomicroscopy-ncle-proposition-of-a-comprehensive-ncle-classification-confirmed-by-an-external-retrospective-evaluation
#19
Bertrand Napoleon, Anne-Isabelle Lemaistre, Bertrand Pujol, Fabrice Caillol, Damien Lucidarme, Raphaël Bourdariat, Blandine Morellon-Mialhe, Fabien Fumex, Christine Lefort, Vincent Lepilliez, Laurent Palazzo, Geneviève Monges, Flora Poizat, Marc Giovannini
BACKGROUND AND AIMS: The differential diagnosis of solitary pancreatic cystic lesions is sometimes difficult. Needle-based confocal laser endomicroscopy (nCLE) performed during endoscopic ultrasound-fine-needle aspiration (EUS-FNA) enables real-time imaging of the internal structure of such cysts. Criteria have already been described for serous cystadenoma and intraductal papillary mucinous neoplasm (IPMN). The aims of the study were to determine new nCLE criteria for the diagnosis of pancreatic cystic lesions, to propose a comprehensive nCLE classification for the characterization of those lesions, and to carry out a first external retrospective validation ...
June 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26374585/hepatogastrostomy-by-eus-for-malignant-afferent-loop-obstruction-after-duodenopancreatectomy
#20
Jean-Philippe Ratone, Fabrice Caillol, Erwan Bories, Christian Pesenti, Sebastien Godat, Marc Giovannini
One of the most difficult biliary drainages is the recurrence and stenosis on afferent loop after surgery. We report an original case of hepaticogastrostomy (HGE) in a patient who had malignant stenosis of afferent loop after cephalic duodenopancreatectomy (CDP). After failure of the gastrointestinal stent, two metal self-expandable stents were placed by endoscopic ultrasound (EUS) after puncture of the dilated left hepatic duct. On clinical improvement and disappearance of jaundice, palliative chemotherapy was started...
July 2015: Endoscopic Ultrasound
keyword
keyword
95004
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"