Adit Friedberg, Lorenzo Pasquini, Ryan Diggs, Erika A Glaubitz, Lucia Lopez, Ignacio Illán-Gala, Leonardo Iaccarino, Renaud La Joie, Nidhi Mundada, Marguerite Knudtson, Kyra Neylan, Jesse Brown, Isabel Elaine Allen, Katherine P Rankin, Luke W Bonham, Jennifer S Yokoyama, Eliana M Ramos, Daniel H Geschwind, Salvatore Spina, Lea T Grinberg, Zachary A Miller, Joel H Kramer, Howard Rosen, Maria Luisa Gorno-Tempini, Gil Rabinovici, William W Seeley, Bruce L Miller
IMPORTANCE: The neurological substrates of visual artistic creativity (VAC) are unknown. VAC is demonstrated here to occur early in frontotemporal dementia (FTD), and multimodal neuroimaging is used to generate a novel mechanistic hypothesis involving dorsomedial occipital cortex enhancement. These findings may illuminate a novel mechanism underlying human visual creativity. OBJECTIVE: To determine the anatomical and physiological underpinnings of VAC in FTD. DESIGN, SETTING, AND PARTICIPANTS: This case-control study analyzed records of 689 patients who met research criteria for an FTD spectrum disorder between 2002 and 2019...
April 1, 2023: JAMA Neurology