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PPAR alpha AND Astaxanthine

Yaoyao Jia, Chunyan Wu, Jiyoung Kim, Bobae Kim, Sung-Joon Lee
We have previously reported that astaxanthin (AX), a dietary carotenoid, directly interacts with peroxisome proliferator-activated receptors PPARα and PPARγ, activating PPARα while inhibiting PPARγ, and thus reduces lipid accumulation in hepatocytes in vitro. To investigate the effects of AX in vivo, high-fat diet (HFD)-fed C57BL/6J mice were orally administered AX (6 or 30mg/kg body weight) or vehicle for 8weeks. AX significantly reduced the levels of triglyceride both in plasma and in liver compared with the control HFD mice...
February 2016: Journal of Nutritional Biochemistry
Yaoyao Jia, Jin-Young Kim, Hee-Jin Jun, Sun-Joong Kim, Ji-Hae Lee, Minh Hien Hoang, Kwang-Yeon Hwang, Soo-Jong Um, Hyo Ihl Chang, Sung-Joon Lee
SCOPE: A natural carotenoid abundant in seafood, astaxanthin (AX), has hypolipidemic activity, but its underlying mechanisms of action and protein targets are unknown. We investigated the molecular mechanism of action of AX in hepatic hyperlipidemia by measuring peroxisome proliferator-activated receptors (PPAR) activity. METHODS AND RESULTS: We examined the binding of AX to PPAR subtypes and its effects on hepatic lipid metabolism. AX binding activated PPAR-α, but inhibited PPAR-γ transactivation activity in reporter gene assay and time-resolved fluorescence energy transfer analyses...
June 2012: Molecular Nutrition & Food Research
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