Xing Zhang, Xiaofeng Ding, Chunqing Wang, Que Le, Dandan Wu, Anying Song, Guixiang Huang, Liping Luo, Yan Luo, Xin Yang, Aleyah E Goins, Sharina P Desai, Chengrui Qiu, Floyd D Silva, Lily Elizabeth Feldman, Jianlin Zhou, Michael F Spafford, Nathan H Boyd, Eric R Prossnitz, Xuexian O Yang, Qiong A Wang, Meilian Liu
The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. Here we show that in male mice, a population of transcription factor jun-B (JunB)-enriched (JunB+ ) adipocytes within the brown adipose tissue exhibits lower thermogenic capacity compared to high-thermogenic adipocytes...
January 8, 2024: Nature metabolism