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https://www.readbyqxmd.com/read/28453757/incidence-and-phenotype-at-diagnosis-of-very-early-onset-compared-with-later-onset-paediatric-inflammatory-bowel-disease-a-population-based-study-1988-2011
#1
E Bequet, H Sarter, M Fumery, F Vasseur, L Armengol-Debeir, B Pariente, D Ley, C Spyckerelle, H Coevoet, J E Laberenne, L Peyrin-Biroulet, G Savoye, D Turck, C Gower-Rousseau
Background and Aims: Very-early-onset inflammatory bowel disease [VEO-IBD] is a form of IBD that is distinct from that of children with an older onset. We compared changes over time in the incidence and phenotype at diagnosis between two groups according to age at IBD diagnosis: VEO-IBD diagnosed before the age of 6 years, and early-onset IBD [EO-IBD] diagnosed between 6 and 16 years of age. Methods: Data were obtained from a cohort enrolled in a prospective French population-based registry from 1988 to 2011...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28449209/the-frequency-of-qtc-prolongation-among-pediatric-and-young-adult-patients-receiving-methadone-for-cancer-pain
#2
Kevin Madden, Minjeong Park, Diane Liu, Eduardo Bruera
INTRODUCTION: A prolonged corrected QT (QTc) interval in pediatric patients is defined as ≥470 msec. Methadone can cause a prolonged QTc interval that can lead to ventricular arrhythmias. The risk of methadone-induced prolongation of the QTc interval in children and young adults is unknown. The purpose of the study was to determine the frequency of QTc prolongation among pediatric and young adult patients with cancer pain on methadone treatment. METHODS: We retrospectively reviewed data for all patients on methadone during the study period...
April 27, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28448685/adult-neurobehavioral-alterations-in-male-and-female-mice-following-developmental-exposure-to-paracetamol-acetaminophen-characterization-of-a-critical-period
#3
Gaëtan Philippot, Torsten Gordh, Anders Fredriksson, Henrik Viberg
Paracetamol (acetaminophen) is a widely used non-prescription drug with analgesic and antipyretic properties. Among pregnant women and young children, paracetamol is one of the most frequently used drugs and is considered the first-choice treatment for pain and/or fever. Recent findings in both human and animal studies have shown associations between paracetamol intake during brain development and adverse behavioral outcomes later in life. The present study was undertaken to investigate if the induction of these effects depend on when the exposure occurs during a critical period of brain development and if male and female mice are equally affected...
April 27, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28445284/appendiceal-foreign-body-in-an-infant
#4
Min Lee, Soon Chul Kim
RATIONALE FOR THIS CASE REPORT: Many children are hospitalized because of foreign body ingestion. In such circumstances, the gastroenterologist must consider the timing of ingestion; the size, type, and location of the object ingested; and the patient's symptoms. But appendiceal foreign body in infant is very rare. PATIENT CONCERNS: A 12-month-old boy visited because of swallowing small objects 2 weeks ago. Three small beads were found in the right lower quadrant on abdominal radiography...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445267/different-clinical-presentations-of-choledochal-cyst-among-infants-and-older-children-a-10-year-retrospective-study
#5
Davoud Badebarin, Saeid Aslanabadi, Amir Teimouri-Dereshki, Masoud Jamshidi, Tuba Tarverdizadeh, Kaveh Shad, Kamyar Ghabili, Ghazal Khajir
Choledochal cyst is a rare and often benign congenital cystic dilation throughout the biliary tree. Due to the benign nature of choledochal cyst among early-diagnosed patients, the clinical assumption and diagnosis seem to be of utmost significance. Therefore, we sought to assess different clinical manifestations of choledochal cyst and relevant laboratory findings in infants and older children.Retrospectively, medical records of all patients with the diagnosis of choledochal cyst between 2005 and 2015 were reviewed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28444856/pharmacokinetics-after-a-single-dose-of-naloxone-administered-as-a-nasal-spray-in-healthy-volunteers
#6
E Vanky, L Hellmundt, U Bondesson, S Eksborg, S Lundeberg
BACKGROUND: There is increasing interest in the use of intranasal naloxone to reverse adverse opioid effects during management of procedural pain in children and in adults after overdose. There are limited data on the pharmacokinetics of intranasal naloxone so in this study we aimed to detail the pharmacokinetic profile of the commercially marketed injectable solution of naloxone 0.4 mg/ml when administered as an intranasal spray. METHODS: Twenty healthy volunteers received naloxone as an intranasal spray at a dose of 10 μg/kg...
April 25, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28442950/effect-of-intranasal-dexmedetomidine-on-emergence-agitation-after-sevoflurane-anesthesia-in-children-undergoing-tonsillectomy-and-or-adenoidectomy
#7
Ahmed Mostafa Abd El-Hamid, Hany Mahmoud Yassin
BACKGROUND: Emergence agitation (EA) after sevoflurane anesthesia is common in children during recovery from general anesthesia and may result in postoperative complications. This study investigated safety and effectiveness of intranasal dexmedetomidine in reducing the incidence and severity of EA. METHODS: This prospective, randomized double-blinded controlled trial included 86 patients scheduled for the tonsillectomy and/or adenoidectomy under general anesthesia with sevoflurane...
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28442927/mechanical-factors-and-vitamin-d-deficiency-in-schoolchildren-with-low-back-pain-biochemical-and-cross-sectional-survey-analysis
#8
Ahmad H Alghadir, Sami A Gabr, Einas S Al-Eisa
OBJECTIVE: This study was designed to evaluate the role of vitamin D, muscle fatigue biomarkers, and mechanical factors in the progression of low back pain (LBP) in schoolchildren. BACKGROUND: Children and adolescents frequently suffer from LBP with no clear clinical causes, and >71% of schoolchildren aged 12-17 years will show at least one episode of LBP. MATERIALS AND METHODS: A total of 250 schoolchildren aged 12-16 years were randomly enrolled in this study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28442839/the-place-of-calprotectin-lactoferrin-and-high-mobility-group-box-1-protein-on-diagnosis-of-acute-appendicitis-with-children
#9
Sevgi Buyukbese Sarsu, Ayse Binnur Erbagci, Hasan Ulusal, Suleyman Cuneyt Karakus, Özlem Gümüstekin Bulbul
The purpose of this study is to investigate the role of serum calprotectin (CP), lactoferrin (LF), and high-mobility group protein B1 (HMGB-1) levels and fecal CP and LF levels in differential diagnosis of acute uncomplicated appendicitis from other causes of abdominal pain and further from complicated appendicitis. Totally, 120 children were included grouped into 4 as: healthy controls, patients with right lower quadrant pain with other than surgical causes, patients with uncomplicated appendicitis, and patients with complicated appendicitis...
April 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28441828/-clinical-analysis-of-seven-cases-of-pulmonary-malignant-tumors-in-children
#10
D Xu, Z M Chen, W Z Gu, Y S Wang, M X Huang, L F Tang, Y Y Zhang, Y Jiang
Objective: To understand the clinical manifestation, imaging characteristics and outcomes of pulmonary malignant tumors in children. Method: We retrospectively collected information about seven cases of pulmonary malignant tumors in children in our hospital from Jan 2010 to Dec 2016. The information included clinical manifestation, imaging characteristics, pathologic results, and treatment. Result: (1) All the seven patients firstly visited pediatric internal medicine departments. Symptoms included cough (n=6), dyspnea (n=4), fever (n=2), anorexia (n=2), chest tightness (n=1), chest pain (n=1), lameness (n=1), abdominal distension and constipation (n=1)...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28441241/pelvic-inflammatory-disease-in-a-pediatric-emergency-department-epidemiology-and-treatment
#11
Michelle Solomon, Lisa Tuchman, Katie Hayes, Gia Badolato, Monika K Goyal
OBJECTIVES: Most adolescent cases of pelvic inflammatory disease (PID) are diagnosed in the emergency department (ED). An important step to prevent PID-related morbidity among this high-risk population is to quantify prevalence and microbial patterns and identify testing and treatment gaps. METHODS: We performed a retrospective, cross-sectional study of all visits by adolescents to an urban children's ED with an International Classification of Diseases, Ninth Revision, diagnosis of PID in 2012...
April 24, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28441163/recognizing-type-1-diabetes-mellitus-in-children-adolescents
#12
Melissa A Glassford
The common chief complaint of abdominal pain, nausea, and vomiting should prompt a broad differential diagnosis list. When a 17-year-old previously healthy male presented to a primary care clinic with these symptoms, it provoked a detailed workup and found a startling diagnosis of type 1 diabetes mellitus (T1DM). This article provides an overview of recognizing T1DM in children and adolescents with a thorough and diagnostic evaluation.
April 24, 2017: Nurse Practitioner
https://www.readbyqxmd.com/read/28438745/management-of-chronic-pain-using-complementary-and-integrative-medicine
#13
REVIEW
Lucy Chen, Andreas Michalsen
Complementary and integrative medicine (CIM) encompasses both Western-style medicine and complementary health approaches as a new combined approach to treat a variety of clinical conditions. Chronic pain is the leading indication for use of CIM, and about 33% of adults and 12% of children in the US have used it in this context. Although advances have been made in treatments for chronic pain, it remains inadequately controlled for many people. Adverse effects and complications of analgesic drugs, such as addiction, kidney failure, and gastrointestinal bleeding, also limit their use...
April 24, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28438377/efficacy-and-safety-of-lactobacillus-plantarum-dsm-9843-lp299v-in-the-prevention-of-antibiotic-associated-gastrointestinal-symptoms-in-children-randomized-double-blind-placebo-controlled-study
#14
Agnieszka Olek, Marek Woynarowski, Irini Lazou Ahrén, Jarosław Kierkuś, Piotr Socha, Niklas Larsson, Gunilla Önning
OBJECTIVES: To determine if Lactobacillus plantarum DSM9843 (LP299V) reduces the frequency of antibiotic-associated loose/watery stools and gastrointestinal symptoms, and can be administered safely to children who are prescribed antibiotics. STUDY DESIGN: We performed a prospective, double-blind, randomized, placebo-controlled, multicenter, parallel-group study in children receiving outpatient antibiotic therapy in primary healthcare settings. The children were given LP299V/placebo during the antibiotic therapy and for 1 week after the end of treatment...
April 21, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28437787/a-comparison-of-three-different-volumes-of-levobupivacaine-for-caudal-block-in-children-undergoing-orchidopexy-and-inguinal-hernia-repair
#15
Vesna Marjanovic, Ivana Budic, Marija Stevic, Dusica Simic
OBJECTIVE: The aim of this study was to compare the efficacy of three different volumes of 0.25% levobupivacaine caudally administered on the effect of intra- and post-operative analgesia in children undergoing orchidopexy and inguinal hernia repair. SUBJECTS AND METHODS: Forty children, aged 1 to 7 years, American Society of Anesthesiologists (ASA) physical status I and II, were randomized into 3 different groups according to the applied volumes of 0.25% levobupivacaine: group 1 (n=13): 0...
April 23, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28435651/a-pediatric-case-of-meckel-diverticulum-with-uncommon-presentation-showing-no-lower-gastrointestinal-bleeding
#16
Sanaz Mehrabani, Soheil Osia
Meckel's diverticulum (MD) is the most common congenital abnormality of the gastrointestinal tract. Painless intestinal hemorrhage is a frequently occurring complication that relates to MD in children. Bowel obstruction is a rare complication of MD in children. We report on the case of a four-year old male child who presented with abdominal pain and hematemesis. Finally, bowel obstruction due to MD was confirmed at surgery.
March 22, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/28435316/subanesthetic-ketamine-for-pain-management-in-hospitalized-children-adolescents-and-young-adults-a-single-center-cohort-study
#17
Kathy A Sheehy, Caroline Lippold, Amy L Rice, Raissa Nobrega, Julia C Finkel, Zenaide Mn Quezado
BACKGROUND: Subanesthetic doses of ketamine, an N-methyl-d-aspartate receptor antagonist used as an adjuvant to opioid for the treatment of pain in adults with acute and chronic pain, have been shown, in some instances, to improve pain intensity and to decrease opioid intake. However, less is known about the role of ketamine in pain management in children, adolescents, and young adults. PURPOSE: We examined the effects of subanesthetic ketamine on pain intensity and opioid intake in children, adolescents, and young adults with acute and chronic pain syndromes treated in an inpatient setting...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28435282/managing-the-patient-with-osteogenesis-imperfecta-a-multidisciplinary-approach
#18
REVIEW
Caroline Marr, Alison Seasman, Nick Bishop
Osteogenesis imperfecta (OI) is a heterogeneous heritable connective tissue disorder characterized by low bone density. The type and severity of OI are variable. The primary manifestations are fractures, bone deformity, and bone pain, resulting in reduced mobility and function to complete everyday tasks. OI affects not only the physical but also the social and emotional well-being of children, young people, and their families. As such, medical, surgical, and allied health professionals' assessments all play a role in the management of these children...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28433976/isolated-duodenal-rupture-primary-repair-without-diversion-is-it-safe-review-of-literature
#19
Muwaffaq Mezeil Telfah
Isolated duodenal rupture is a rare injury encountered among children following blunt abdominal trauma. Early diagnosis and treatment are essential to decrease the associated morbidity and mortality. The debate is about the optimum operative management. We report a 6-year-old child who presented with acute abdominal pain due to isolated duodenal injury following blunt abdominal trauma. Emergency laparotomy revealed duodenal rupture at the junction of the first and second part of duodenum and absence of any other visceral injuries...
April 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28433546/symptom-trajectories-in-children-receiving-treatment-for-leukemia-a-latent-class-growth-analysis-with-multitrajectory-modeling
#20
Marilyn J Hockenberry, Mary C Hooke, Cheryl Rodgers, Olga Taylor, Kari M Koerner, Pauline Mitby, Ida Moore, Michael E Scheurer, Wei Pan
CONTEXT: Cancer treatment symptoms play a major role in determining the health of children with cancer. Symptom toxicity often results in complications, treatment delays, and therapy dose reductions that can compromise leukemia therapy and jeopardize chances for long-term survival. Critical to understanding symptom experiences during treatment is the need for exploration of "why" inter-individual symptom differences occur; this will determine who may be most susceptible to treatment toxicities...
April 19, 2017: Journal of Pain and Symptom Management
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