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https://www.readbyqxmd.com/read/29031225/cube-shaped-theranostic-paclitaxel-prodrug-nanocrystals-with-surface-functionalization-of-spc-and-mpeg-dspe-for-imaging-and-chemotherapy
#1
Fuqiang Guo, Jiajia Shang, Hai Zhao, Kangrong Lai, Yang Li, Zhongxiong Fan, Zhenqing Hou, Guanghao Su
As one of nanomedicine delivery systems (NDSs), drug nanocrystals exhibited an excellent anticancer effect. Recently, differences of internalization mechanisms and subcellular localization of both drug nanocrystals and small molecular free drug have drawn much attention. In this paper, paclitaxel (PTX) as a model anticancer drug was directly labeled with 4-chloro-7-nitro-1, 2, 3-benzoxadiazole (NBD-Cl) (a drug-fluorophore conjugate Ma et al. (2016) and Wang et al. (2016) [1,2] (PTX-NBD)). PTX-NBD was synthesized by nucleophilic substitution reaction of PTX with NBD-Cl in high yield and characterized by fluorescence, XRD, ESI-MS, and FT-IR analysis...
October 5, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031173/an-unusual-case-of-transpelvic-impalement-injury-a-case-report
#2
Mushrek Alani, Saeed Mahmood, Ayman El-Menyar, Sajid Atique, Hassan Al-Thani, Ruben Peralta
INTRODUCTION: Impalement injury is a rare type of mechanical injury following forceful insertion of projecting object into the body. Careful planning for removal of the impaling object is essential to decrease the blood loss and preserve the function of the injured organ. PRESENTATION OF CASE: A 27 year-old male fell from 4m height over a U shaped projecting up metallic bar. The bar penetrated the left side of the pelvis and traversed through the left iliac bone causing a comminuted fracture in the supra-acetabular region extending to the left psoas muscle, injuring the viscera and causing fracture of the right femur...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29031168/effect-of-microstructural-elongation-on-backscattered-field-intensity-measurement-and-multiple-scattering-estimation-with-a-linear-transducer-array
#3
Aurélien Baelde, Jérôme Laurent, Pierre Millien, Richard Coulette, Warida Ben Khalifa, Frédéric Jenson, Fan Sun, Mathias Fink, Claire Prada
The effect of microstructural elongation on ultrasonic backscattered fields was studied. Two methods for determining the elongation direction of macrozones in titanium alloys, using the anisotropic spatial coherence of the backscattered field, are presented. Both methods use a phased array attached on a rotative holder that records the array response matrix at several angles. Two titanium alloys were investigated: TA6V and Ti17. TA6V exhibited a strong macrozone elongation, whereas Ti17 macrozones were found equiaxial...
September 20, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29031165/characterization-and-morphological-analysis-of-individual-aerosol-of-pm10-in-urban-area-of-lucknow-india
#4
Sushil Kumar Bharti, Dhananjay Kumar, Sangeeta Anand, Poonam, Shymal Chandra Barman, Narendra Kumar
Airborne particulate matters were collected during the period of October 2015 to September 2016 in Lucknow at different sampling sites. The annual mean concentration of particulate matter was found to be relatively higher than the limits prescribed by National ambient air quality standards (NAAQS), United State Environmental Protection Agency (USEPA) and World Health Organization (WHO). Particulate matters were studied for morphological analysis, elemental composition and functional group variability with the help of Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDS) followed by Fourier Transform Infrared spectroscopy (FTIR)...
September 14, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/29031121/facilitating-decision-making-in-women-undergoing-genetic-testing-for-hereditary-breast-cancer-breconda-randomized-controlled-trial-results
#5
Kerry A Sherman, Christopher J Kilby, Laura-Kate Shaw, Caleb Winch, Judy Kirk, Kathy Tucker, Elisabeth Elder
BACKGROUND: Decision-making concerning risk-reducing mastectomy for women at hereditary risk of breast cancer entails complex personal choices. Deciding whether and how to restore breast shape after risk-reducing mastectomy is a key part of this process. We developed a web-based decision aid, BRECONDA (Breast Reconstruction Decision Aid), to assist women in decision-making regarding breast reconstruction. METHOD: This study assessed the efficacy of BRECONDA to assist women at increased risk of breast cancer in making decisions regarding risk-reducing mastectomy in terms of decisional conflict, knowledge, and satisfaction with information...
October 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29031107/accuracy-precision-and-inter-rater-reliability-of-micro-ct-analysis-of-false-starts-on-bones-a-preliminary-validation-study
#6
Guido Pelletti, Giovanni Cecchetto, Alessia Viero, Paolo Fais, Michael Weber, Diego Miotto, Massimo Montisci, Guido Viel, Chiara Giraudo
Micro computed tomography (micro-CT) has already been proposed as a useful technique for the qualitative analysis of false starts (FS) produced on human bones, although the reliability and the error rate of this technique have not been tested yet, neither for qualitative nor for quantitative assessments. The aim of the present study was to test the morphological agreement, accuracy, precision and inter-rater reliability of micro-CT analysis of FS on bones. The morphological agreement was assessed through the degree of concordance among the 3 independent blind raters in the identification of the shape of 24 FS manually produced on bones by 3 different saws (8 FS for each saw)...
October 6, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29031096/removal-of-metallic-al-and-al-zn-alloys-in-mswi-bottom-ash-by-alkaline-treatment
#7
Dongxing Xuan, Chi Sun Poon
In order to reduce the leaching of pollutants and remove the Al and Zn/Al alloy from municipal solid waste incineration bottom ash (MSWIBA), an optimized alkaline pre-treatment procedure was developed in this study. The influences of alkaline conditions on the removal rate of Al and Zn/Al alloy were investigated, including [OH](-) concentration, temperature, particle size, liquid/solid ratio and treatment duration. The experimental results showed that the optimized alkaline pre-treatment conditions to efficiently remove the Al and Zn/Al alloy was by using a minimum of 1...
October 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29029329/a-new-anthropophilic-species-of-simulium-trichodagmia-diptera-simuliidae-from-amazonia-morphology-chromosomes-and-dna-sequences
#8
Jeane Marcelle Cavalcante Do Nascimento, Neusa Hamada, Vanderly Andrade-Souza, Peter H Adler
The black fly Simulium (Trichodagmia) hirtipupa Lutz (Diptera: Simuliidae) is widely distributed in southern Brazil, with one report from Amapá state in the northern region of Brazilian Amazonia. Morphological comparison of northern and southern populations revealed differences in all life stages, corroborated by chromosomal and molecular analyses, and indicated that the population previously identified as S. hirtipupa from Amapá state represents an undescribed species. This new species is described based on all life stages above the egg, and its chromosomal and molecular divergence from S...
October 2, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029264/a-general-model-for-estimating-macroevolutionary-landscapes
#9
Florian C Boucher, Vincent Démery, Elena Conti, Luke J Harmon, Josef Uyeda
The evolution of quantitative characters over long timescales is often studied using stochastic diffusion models. The current toolbox available to students of macroevolution is however limited to two main models: Brownian motion and the Ornstein-Uhlenbeck process, plus some of their extensions. Here we present a very general model for inferring the dynamics of quantitative characters evolving under both random diffusion and deterministic forces of any possible shape and strength, which can accommodate interesting evolutionary scenarios like directional trends, disruptive selection, or macroevolutionary landscapes with multiple peaks...
September 22, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29029220/effect-of-host-traits-and-land-use-changes-on-the-gut-microbiota-of-the-namibian-black-backed-jackal-canis-mesomelas
#10
Sebastian Menke, Matthias Meier, John K E Mfune, Joerg Melzheimer, Bettina Wachter, Simone Sommer
Host traits and environmental factors drive the natural variation in gut microbiota and disruption in homeostasis can cause infections and chronic diseases. African wildlife is increasingly facing human-induced agricultural habitats, which also amplifies the contact probability with livestock with unknown consequences for wildlife gut microbiotas and the risk of transmission of potentially pathogenic bacteria. We applied high-throughput sequencing of bacterial 16S rRNA genes and microsatellite genotyping to investigate the impact of host traits and habitat use on the gut microbiotas of black-backed jackals (Canis mesomelas)...
September 25, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29029038/geographical-distance-and-local-environmental-conditions-drive-the-genetic-population-structure-of-a-freshwater-microalga-bathycoccaceae-chlorophyta-in-patagonian-lakes
#11
Leonardo D Fernández, Cristián E Hernández, M Romina Schiaffino, Irina Izaguirre, Enrique Lara
The patterns and mechanisms underlying the genetic structure of microbial populations remain unresolved. Herein we investigated the role played by two non-mutually exclusive models (i.e. isolation by distance and isolation by environment) in shaping the genetic structure of lacustrine populations of a microalga (a freshwater Bathycoccaceae) in the Argentinean Patagonia. To our knowledge, this was the first study to investigate the genetic population structure in a South American microorganism. Population-level analyses based on ITS1-5...
October 3, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29028985/impact-of-coronary-lumen-reconstruction-on-the-estimation-of-endothelial-shear-stress-in-vivo-comparison-of-three-dimensional-quantitative-coronary-angiography-and-three-dimensional-fusion-combining-optical-coherent-tomography
#12
Jihoon Kweon, Soo-Jin Kang, Young-Hak Kim, June-Goo Lee, Seungbong Han, Hojin Ha, Dong Hyun Yang, Joon-Won Kang, Tae-Hwan Lim, Osung Kwon, Jung-Min Ahn, Pil Hyung Lee, Duk-Woo Park, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Aims: It is not clearly elucidated how the fusion technique improves the accuracy of endothelial shear stress (ESS) prediction, in comparison with that of three-dimensional (3D) quantitative coronary angiography (QCA) alone. We aimed to evaluate the difference in geometric measurements and haemodynamic estimation between 3D QCA and a 3D fusion model combining 3D QCA and optical coherence tomography (OCT). Methods and results: Computational fluid dynamics was assessed in the coronary models of 20 patients...
September 25, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29028862/alternatives-to-standard-injectables-and-devices-for-rejuvenation
#13
Sabine Zenker
<p>INTRODUCTION: Looking at alternatives to standard injectables and devices for rejuvenation, typical indications for facial rejuvenation are poor skin quality, pigmentary changes, and the loss of shape. Looking for effective treatments for those indications in the aesthetic field, one can notice a kind of "retro"-trend: easy-to-perform, non- or minimally-invasive, low-investment-requiring procedures are regaining a lot of popularity. And, over time, those treatments are becoming well defined and far more specific...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29028609/daunorubicin-and-doxorubicin-molecular-interplay-with-2d-membrane-models
#14
Ana Catarina Alves, Cláudia Nunes, José Lima, Salette Reis
The anthracyclines daunorubicin and doxorubicin are widely used antineoplastic agents due to their therapeutic activity against a broad variety of human cancers. Although, the classical model to explain anthracyclines' cytotoxicity has been based in the direct interference with nucleic acid function, evidence suggests that the plasma membrane is also involved in the drug's mechanism of action. In this work, the interaction of these drugs with two-dimensional membrane models were studied in order to gain further insights at the molecular level regarding anthracyclines membrane interactions...
October 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29028575/green-synthesis-of-highly-dispersed-ytterbium-and-thulium-co-doped-sodium-yttrium-fluoride-microphosphors-for-in-situ-light-upconversion-from-near-infrared-to-blue-in-animals
#15
Yuan Pu, Lifeng Lin, Dan Wang, Jie-Xin Wang, Jun Qian, Jian-Feng Chen
We report a simple, low cost and environmentally friendly method to prepare NaYF4:Yb(3+), Tm(3+) upconversion microphosphors (UCMPs) by thermal decomposition of rare earth-trifluoroacetate precursors using paraffin as the high boiling non-coordinating solvent. The UCMPs exhibited cubic phase with defined shape and bright upconversion luminescence. After coating with amphiphilic polymers of phospholipid-polyethylene glycol, the NaYF4:Yb(3+), Tm(3+) UCMPs were highly dispersed in aqueous solutions and exhibited low cytotoxicity...
October 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028572/supramolecular-gels-using-an-amide-functionalized-imidazolium-based-surfactant
#16
Ni Cheng, Qi Kang, Jianhong Xiao, Na Du, Li Yu
Studies on supramolecular gel aggregates via supramolecular interactions are very fascinating and impressive. The interactions of gelator with solvent and inorganic salt can functionalize, activate, or control the properties of supramolecular gels. A lot of work on this area has been done, but all these contributions are only at an early stage. In this work, we tuned the gel formation conditions and properties by using low-molecular-weight gelator (LMWGs), amide-functionalized imidazolium-based surfactant, viz...
October 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29028564/assessing-police-officers-attitudes-and-legal-knowledge-on-behaviors-that-impact-hiv-transmission-among-people-who-inject-drugs
#17
Javier A Cepeda, Steffanie A Strathdee, Jaime Arredondo, Maria L Mittal, Teresita Rocha, Mario Morales, Erika Clairgue, Eliane Bustamante, Daniela Abramovitz, Irina Artamonova, Arnulfo Bañuelos, Thomas Kerr, Carlos L Magis-Rodriguez, Leo Beletsky
BACKGROUND: Policing practices such as syringe confiscation and arrest can act as important social-structural drivers of HIV risk among people who inject drugs (PWID). However, police referral to treatment and other services may improve the health of PWID. Little is known about the role of modifiable attitudinal and knowledge factors in shaping officer behavior. Using baseline findings from a police education program (PEP), we assessed relationships between drug policy knowledge and attitudes towards public health interventions with self-reported syringe confiscation, drug arrest, and service referral among street-level police in Tijuana, Mexico...
October 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29028561/stability-and-drug-release-studies-of-an-antimycotic-nanomedicine-using-hplc-dynamic-light-scattering-and-atomic-force-microscopy
#18
Ayako Watanabe, Mio Takagi, Shigeo Murata, Masaru Kato
Much attention has been paid to nanoparticle-based drug delivery systems to selectively deliver drugs to target organs and tissues. In this study, AmBisome, an antimycotic nanomedicine containing amphotericin B, was chosen as a typical nanomedicine, and analyzed using dynamic light scattering (DLS), an easy method to measure size, and size distribution, atomic force microscopy (AFM) and high-performance liquid chromatography (HPLC). AFM allowed the analysis of shape, besides a detailed size and size distribution...
September 25, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29028515/post-biopsy-mri-changes-in-the-size-and-enhancement-of-intramuscular-myxomas-a-report-of-two-cases
#19
Wilbur Wang, Edward Smitaman, Wesley Rubenstein, Tudor Hughes, Brady K Huang
Intramuscular myxomas are benign soft-tissue tumors, characterized by bland spindle-shaped cells and fibroblasts within an abundant mucoid matrix on histologic examination. Classically, these are slowly enlarging masses which may occasionally cause pain, paresthesia, and muscle weakness secondary to mass effect. We present an interesting phenomenon of two histologically confirmed cases of intramuscular myxomas that exhibited size and enhancement changes on follow-up imaging after image-guided biopsy. To our knowledge, this is the first report to describe size and enhancement changes of intramuscular myxomas after biopsy...
September 28, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29028495/non-cytotoxic-effect-of-green-synthesized-silver-nanoparticles-and-its-antibacterial-activity
#20
B Senthil, T Devasena, B Prakash, A Rajasekar
Silver nanoparticles (AgNPs) were green synthesized using ethanolic extract of fenugreek leaves and characterized using UV-Vis spectroscopy, Fourier transform infra-red spectroscopy (FTIR), X-ray diffraction (XRD), high resolution transmission electron microscopy HRTEM and energy dispersive X-ray analysis (EDX) techniques. The HRTEM results revealed the formation of highly stable, mono dispersed, spherical shaped AgNPs with the size ranging from 20 to 30nm. The presence of flavonoids and their interaction with the AgNPs were confirmed using FTIR...
October 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
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