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https://www.readbyqxmd.com/read/29684945/-it-s-going-to-be-extra-fun-analysis-of-an-atypical-case-of-teen-homicide-as-leisure-behavior
#1
D J Williams, Jolene Vincent
Recently, scholars in literary criminology and leisure sciences have begun to explore the role of broader leisure culture in potentially shaping fantasy development, planning, preparation, and execution in specific cases of expressive homicide. This brief report focuses on an unusual case of expressive homicide, wherein two teen offenders in Idaho collaborated to murder a female classmate as an intentional leisure activity. Prior to the murder, the offenders created a videotape describing how they planned to commit this (and additional) murders...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29684854/the-role-of-her2-nrf2-axis-in-induction-of-oxaliplatin-resistance-in-colon-cancer-cells
#2
Abbas Pirpour Tazehkand, Maryam Akbarzadeh, Kobra Velaie, Mohammad Reza Sadeghi, Nasser Samadi
Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a pivotal role in promoting chemoresistance by regulation of antioxidants and detoxification enzymes. Her2 is a member of tyrosine kinase receptor family with a key function in resistance of cancer cells to chemotherapeutics. The aim of this study was to investigate the possible cross talk between Nrf2 and Her2 mediated signaling pathways in development of oxaliplatin resistance in colon cancer cells. We first generated oxaliplatin-resistant LS174T and SW480 colon cancer cells with different Her2 expression levels by employing IC50 concentrations followed by a resting period...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684783/accurate-segmenting-of-cervical-tumors-in-pet-imaging-based-on-similarity-between-adjacent-slices
#3
Liyuan Chen, Chenyang Shen, Zhiguo Zhou, Genevieve Maquilan, Kimberly Thomas, Michael R Folkert, Kevin Albuquerque, Jing Wang
Because in PET imaging cervical tumors are close to the bladder with high capacity for the secreted 18 FDG tracer, conventional intensity-based segmentation methods often misclassify the bladder as a tumor. Based on the observation that tumor position and area do not change dramatically from slice to slice, we propose a two-stage scheme that facilitates segmentation. In the first stage, we used a graph-cut based algorithm to obtain initial contouring of the tumor based on local similarity information between voxels; this was achieved through manual contouring of the cervical tumor on one slice...
April 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29684750/knowledge-about-writing-influences-reading-dynamic-visual-information-about-letter-production-facilitates-letter-identification
#4
Teresa Schubert, Caroline Reilhac, Michael McCloskey
How are reading and writing related? In this study, we address the relationship between letter identification and letter production, uncovering a link in which production information can be used to identify letters presented dynamically. By testing an individual with a deficit in letter identification, we identified a benefit which would be masked by ceiling effects in unimpaired readers. In Experiment 1 we found that letter stimuli defined by the direction of dot motion (tiny dots within letter move leftward, background dots move rightward) provided no advantage over static letters...
March 30, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29684732/low-frequency-complex-dielectric-conductivity-response-of-dilute-clay-suspensions-modeling-and-experiments
#5
Chang-Yu Hou, Ling Feng, Nikita Seleznev, Denise E Freed
In this work, we establish an effective medium model to describe the low-frequency complex dielectric (conductivity) dispersion of dilute clay suspensions. We use previously obtained low-frequency polarization coefficients for a charged oblate spheroidal particle immersed in an electrolyte as the building block for the Maxwell Garnett mixing formula to model the dilute clay suspension. The complex conductivity phase dispersion exhibits a near-resonance peak when the clay grains have a narrow size distribution...
April 11, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29684709/the-role-of-natural-selection-in-shaping-genetic-variation-in-a-promising-chagas-disease-drug-target-trypanosoma-cruzi-trans-sialidase
#6
Joseph P Gallant, Raquel Asunción Lima-Cordón, Silvia Justi, Maria Carlota Monroy, Toni Viola, Lori Stevens
Rational drug design creates innovative therapeutics based on knowledge of the biological target to provide more effective and responsible therapeutics. Chagas disease, endemic throughout Latin America, is caused by Trypanosoma cruzi, a protozoan parasite. Current therapeutics are problematic with widespread calls for new approaches. Researchers are using rational drug design for Chagas disease and one target receiving considerable attention is the T. cruzi trans-sialidase protein (TcTS). In T. cruzi, trans-sialidase catalyzes the transfer of sialic acid from a mammalian host to coat the parasite surface membrane and avoid immuno-detection...
April 20, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29684699/support-media-can-steer-methanogenesis-in-the-presence-of-phenol-through-biotic-and-abiotic-effects
#7
Simon Poirier, Sébastien Déjean, Olivier Chapleur
A wide variety of inhibitors can induce anaerobic digester disruption. To avoid performance losses, support media can be used to mitigate inhibitions. However, distinguishing the physico-chemical from the biological mechanisms of such strategies remains delicate. In this framework, the impact of 10  g/L of different types of zeolites and activated carbons (AC) on microbial community dynamics during anaerobic digestion of biowaste in the presence of 1.3 g/L of phenol was evaluated with 16 S rRNA gene sequencing...
April 13, 2018: Water Research
https://www.readbyqxmd.com/read/29684676/fabrication-of-nanofibrous-microcarriers-mimicking-extracellular-matrix-for-functional-microtissue-formation-and-cartilage-regeneration
#8
Yansen Wang, Xueling Yuan, Kun Yu, Haoye Meng, Yudong Zheng, Jiang Peng, Shibi Lu, Xiaotong Liu, Yajie Xie, Kun Qiao
Cartilage has rather limited capacities for self-repair and regeneration. To repair complexly shaped cartilage tissue defects, we propose the application of microtissues fabricated from bone marrow-derived mesenchymal stem cells (BMSCs) cultured in natural bionic nanofibrous microcarriers (NF-MCs). The NF-MCs were structurally and functionally designed to mimic natural extracellular matrix (ECM) by crosslinking dialdehyde bacterial cellulose (DBC) with DL-allo-hydroxylysine (DHYL) and complexing chitosan (CS) with DHYL through electrostatic interactions...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29684652/generosity-and-compliance-recruitment-work-and-the-pathways-to-participation-in-bone-marrow-donation
#9
Kushan Dasgupta
This study examines challenges involved in recruiting bone marrow donors. Data comes from participant observation with a recruitment organization in the United States. Findings reveal that recruiters try to express bone marrow donation with common "gift of life" messaging, which emphasizes a singular event involving generosity. Potential recruits, however, respond by focusing on pain and time commitments. These concerns draw attention to the many stages and requirements involved in bone marrow donation and make issues of compliance salient...
April 12, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684483/three-dimensional-protein-shape-similarity-analysis-based-on-hybrid-features
#10
Zhong Li, Jiangjiang Yu, Hailong Hu, Shuiwang Ji
The analysis of protein similarity is a matter of concern in the bioinformatics field, since studying the protein similarity can help understand the protein structure-function relationship. To this aim, several methods have been proposed, but currently, protein similarity results are still not satisfactory. Here we presented a novel method for evaluating the similarity of 3D protein models based on hybrid features, including the local diameter (LD), the salient geometric feature (SGF) and the heat kernel signature (HKS)...
April 20, 2018: Gene
https://www.readbyqxmd.com/read/29684408/development-of-a-new-punch-head-shape-to-replicate-scale-up-issues-on-a-laboratory-tablet-press-iii-replicating-sticking-phenomenon-using-the-sas-punch-and-evaluation-by-checking-the-tablet-surface-using-3d-laser-scanning-microscope
#11
Manabu Ito, Shigeru Aoki, Jumpei Uchiyama, Keisuke Yamato
Sticking is a common observation in the scale-up stage on the punch tip using a commercial tableting machine. The difference in the total compression time between a laboratory and a commercial tableting machine is considered one of the main root causes of scale up issues in the tableting processes. The proposed Size Adjusted for Scale-up (SAS) punch can be used to adjust the consolidation and dwell times for commercial tableting machine. As a result, the sticking phenomenon is able to be replicated at the pilot scale stage...
April 20, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29684407/modelling-singular-perturbation-and-bifurcation-analyses-of-bitrophic-food-chains
#12
B W Kooi, J C Poggiale
Two predator-prey model formulations are studied: for the classical Rosenzweig-MacArthur (RM) model and the Mass Balance (MB) chemostat model. When the growth and loss rate of the predator is much smaller than that of the prey these models are slow-fast systems leading mathematically to singular perturbation problem. In contradiction to the RM-model, the resource for the prey are modelled explicitly in the MB-model but this comes with additional parameters. These parameter values are chosen such that the two models become easy to compare...
April 20, 2018: Mathematical Biosciences
https://www.readbyqxmd.com/read/29684402/on-the-genesis-of-spatial-numerical-associations-evolutionary-and-cultural-factors-co-construct-the-mental-number-line
#13
REVIEW
Elizabeth Y Toomarian, Edward M Hubbard
Mapping numbers onto space is a common cognitive representation that has been explored in both behavioral and neuroimaging contexts. Empirical work probing the diverse nature of these spatial-numerical associations (SNAs) has led researchers to question 1) how the human brain links numbers with space, and 2) whether this link is biologically vs. culturally determined. We review the existing literature on the development of SNAs and situate that empirical work within cognitive and neuroscientific theoretical frameworks...
April 20, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29684355/morphology-of-the-terminal-abdominal-segments-in-females-of-triatominae-insecta-hemiptera-reduviidae
#14
Juliana Mourão Dos Santos Rodrigues, João Aristeu da Rosa, Felipe Ferraz Figueiredo Moreira, Cleber Galvão
Triatominae (Insecta: Hemiptera: Reduviidae) includes 151 extant species that are all potential vectors of Chagas disease. The relationships among these species have been recently studied based on molecular and cytogenetical approaches, and although the morphology of these insects is fairly described, wide comparative studies and cladistics analysis based on this feature are lacking. A comparative study of the terminal abdominal segments in females of 26 species of Triatominae was performed in order to evaluate their importance for the distinction of genera and species, and obtain characters to be used in cladistics analyses...
April 20, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29684331/cholesterol-is-enriched-in-the-sphingolipid-patches-on-the-substrate-near-nonpolarized-mdck-cells-but-not-in-the-sphingolipid-domains-in-their-plasma-membranes
#15
Ashley N Yeager, Peter K Weber, Mary L Kraft
Information about the distributions of cholesterol and sphingolipids within the plasma membranes of mammalian cells provides insight into the roles of these molecules in membrane function. In this report, high-resolution secondary ion mass spectrometry was used to image the distributions of metabolically incorporated rare isotope-labeled sphingolipids and cholesterol on the surfaces of nonpolarized epithelial cells. Sphingolipid domains that were not enriched with cholesterol were detected in the plasma membranes of subconfluent Madin-Darby canine kidney cells...
April 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29684253/cover-image-volume-115-number-6-june-2018
#16
Yuki Matsushiro, Midori Kato-Negishi, Hiroaki Onoe
The cover image, by Yuki Matsushiro et al., is based on the Article Differentiation of 3D-shape-controlled mouse neural stem cell to neural tissues in closed agarose microchambers, DOI 10.1002/bit.26559.
June 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29684153/determination-of-cytoplasmic-optineurin-foci-sizes-using-image-correlation-spectroscopy
#17
Akira Kitamura, Hiroki Shimizu, Masataka Kinjo
Optineurin (OPTN) plays an important role in membrane trafficking processes such as exocytosis and autophagy. The sizes and rate of formation of accumulated structures comprising OPTN, such as foci or inclusion bodies (IBs), are often disrupted by amyotrophic lateral sclerosis (ALS) and glaucoma-associated mutants of OPTN. Therefore, methods for the quantitative measurement of the size of the accumulated structure are necessary. Here, we show that, using spatial image correlation spectroscopy (ICS), the average diameter of accumulated structures of the wild type and disease-associated mutants in living cells may be easily determined...
April 19, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29684128/understanding-australian-policies-on-public-health-using-social-and-political-science-theories-reflections-from-an-academy-of-the-social-sciences-in-australia-workshop
#18
Fran Baum, Adam Graycar, Toni Delany-Crowe, Evelyne de Leeuw, Carol Bacchi, Jennie Popay, Lionel Orchard, Hal Colebatch, Sharon Friel, Colin MacDougall, Elizabeth Harris, Angela Lawless, Dennis McDermott, Matthew Fisher, Patrick Harris, Clare Phillips, Jane Fitzgerald
There is strong, and growing, evidence documenting health inequities across the world. However, most governments do not prioritize policies to encourage action on the social determinants of health and health equity. Furthermore, despite evidence concerning the benefits of joined-up, intersectoral policy to promote health and health equity, it is rare for such policy approaches to be applied systematically. To examine the usefulness of political and social science theory in understanding the reasons for this disjuncture between evidence and practice, researchers and public servants gathered in Adelaide for an Academy of the Social Sciences in Australia (ASSA) Workshop...
April 19, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29684097/biology-of-pityophthorus-pulchellus-tuberculatus-coleoptera-curculionidae-scolytinae-in-lodgepole-pine-in-northern-idaho
#19
Malcolm M Furniss, Sandra J Kegley
The twig beetle, Pityophthorus pulchellus tuberculatus Eichhoff, infests dead branches of pines in western United States and Canada, including lodgepole pine, Pinus contorta Douglas, in northern Idaho. Adult broods overwintered in their host and emerged and colonized new hosts in late April. Males initiated galleries and were joined by up to seven females, each of which constructed an egg gallery radiating from a central chamber. Galleries had an average of 4.7 egg niches each with an egg that was large relative to the mother beetle...
April 19, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29684041/public-perceptions-about-climate-change-mitigation-in-british-columbia-s-forest-sector
#20
Guillaume Peterson St-Laurent, Shannon Hagerman, Robert Kozak, George Hoberg
The role of forest management in mitigating climate change is a central concern for the Canadian province of British Columbia. The successful implementation of forest management activities to achieve climate change mitigation in British Columbia will be strongly influenced by public support or opposition. While we now have increasingly clear ideas of the management opportunities associated with forest mitigation and some insight into public support for climate change mitigation in the context of sustainable forest management, very little is known with respect to the levels and basis of public support for potential forest management strategies to mitigate climate change...
2018: PloS One
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