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Srujana Vedicherla, Sara Romanazzo, Daniel J Kelly, Conor T Buckley, Cathal J Moran
Purpose/aim of study: Menisectomies account for over 1.5 million surgical interventions in Europe annually, and there is a growing interest in regenerative strategies to improve outcomes in meniscal replacement. The overall objective of this study was to evaluate the role of intraoperatively applied fresh chondrocyte (FC) isolates compared to minced cartilage (MC) fragments, used without cell isolation, to improve bioactivity and tissue integration when combined with a polyurethane replacement. MATERIALS AND METHODS: First, to optimize the intraoperative cell isolation protocol, caprine articular cartilage biopsies were digested with 750 U/ml or 3000 U/ml collagenase type II (ratio of 10 ml per g of tissue) for 30 min, 1 h or 12 h with constant agitation and compared to culture-expanded chondrocytes in terms of matrix deposition when cultured on polyurethane scaffolds...
November 28, 2017: Connective Tissue Research
Sonia Nasi, Hang-Korng Ea, Alexander So, Nathalie Busso
Background: Innate immune response components such as toll-like receptors (TLRs) and NLRP3-inflammasome act in concert to increase IL-1α/β secretion by synovial macrophages. Previous results suggest that IL-1α/β could be an important mediator involved in the pathogenesis of osteoarthritis (OA). Objectives: The aim of our study was to evaluate the role of NLRP3, IL-1β, and IL-1α in the menisectomy (MNX) model of murine OA. Methods: Murine chondrocytes (CHs) and bone marrow-derived machrophages (BMDM) were stimulated with hydroxyapatite (HA) crystals, a form of calcium-containing crystal found in human OA, and IL-1β and IL-6 secretion assayed by ELISA...
2017: Frontiers in Pharmacology
Samuel C Willimon, Marjorie M Johnson, Mackenzie M Herzog, Michael T Busch
BACKGROUND: Return to school among adolescents is often overlooked in orthopaedic outcome studies. The purpose was to measure the time missed from school after 10 common orthopedic surgeries. METHODS: Patients, 5 to 19 years old enrolled in elementary, middle, or high school, who underwent treatment for fixation of type III supracondylar humerus fracture, midshaft femur fracture fixation, isolated anterior cruciate ligament reconstruction, isolated partial menisectomy, adolescent idiopathic scoliosis fusion, closed reduction of both-bone forearm fracture, arthroscopic Bankart repair, hip arthroscopy with femoroacetabular impingement correction, limb length discrepancy correction, or surgical fixation of slipped capital femoral epiphysis during the 2014/2015 and 2015/2016 school years were identified for this Institutional Review Board-approved study...
January 30, 2017: Journal of Pediatric Orthopedics
Prafulla Herode, Abhijeet Shroff, Vishal Mandlewala, Amit Chaudhary
INTRODUCTION: Meniscal cysts are rare, in that cysts of lateral meniscus are 3 times to 10 times more common than those of medial meniscus. Etiology of meniscal cysts includes trauma which results in contusion and haemorrage within the substance of meniscus leading to mucoid degeneration. Degeneration with age results in local necrosis and mucoid degeneration into a cyst, developmental inclusion of synovial cells within the substance of the meniscus and often are a result of extrusion of synovial fluid through a tear of the meniscus, resulting in a one-way valve effect of the tear...
July 2016: Journal of Orthopaedic Case Reports
Håvard Østerås
No abstract text is available yet for this article.
January 2017: Journal of Physiotherapy
Priya Jeyaraj, Ashish Chakranarayan
Chronic protracted dislocation of the TMJ is a relatively uncommon but extremely unpleasant and distressing condition for a patient. It is also particularly challenging and difficult to treat as it worsens with time due to continuing spasm of the masticatory muscles and progressive fibrosis, adhesions and consolidation in and around the dislocated joint. No definite guidelines or treatment protocols have been laid down in literature till date, towards management of such dislocations. A range of extensive and invasive surgical procedures such as eminectomy, condylectomy, menisectomy, and various osteotomies of the mandibular ramus and body have been performed to reduce these dislocations...
July 2016: Journal of Maxillofacial and Oral Surgery
Sonia Nasi, Hang-Korng Ea, Frédéric Lioté, Alexander So, Nathalie Busso
OBJECTIVES: Calcium-containing crystals participate in the pathogenesis of OA. Sodium thiosulfate (STS) has been shown to be an effective treatment in calcification disorders such as calciphylaxis and vascular calcification. This study investigated the effects and mechanisms of action of STS in a murine model of OA and in chondrocyte calcification. METHODS: Hydroxyapatite (HA) crystals-stimulated murine chondrocytes and macrophages were treated with STS. Mineralization and cellular production of IL-6, MCP-1 and reactive oxygen species (ROS) were assayed...
2016: PloS One
M-W Dai, J-G Chu, F-M Tian, H-P Song, Y Wang, Y-Z Zhang, L Zhang
OBJECTIVE: To evaluate the effects of PTH(1-34) on cartilage, subchondral bone mass and structure in medial meniscectomized guinea pigs and compare them to those of celecoxib (CLX). METHOD: Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations. One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group...
June 2016: Osteoarthritis and Cartilage
E Sallé de Chou, N Pujol, G Rochcongar, T Cucurulo, J F Potel, F Dalmay, F P Ehkirch, C Laporte, G Le Henaff, R Seil, C Lutz, F X Gunepin, B Sonnery-Cottet
INTRODUCTION: Symptomatic horizontal meniscal tears are rare but worrisome lesions in young adults. These are overuse injuries not amenable to the classic arthroscopic sutures. An open meniscal repair allows the meniscal lesion to be suture vertically, perpendicular to its in the vascularized zone. The purpose of this study was to evaluate the short and long-term clinical and radiological outcomes of the aforementioned surgical technique. MATERIAL AND METHOD: The first cohort consisted of 24 patients operated between 2009 and 2011 (6 women, 18 men; mean age 26years) having 11 lateral and 13 medial meniscal tears...
December 2015: Orthopaedics & Traumatology, Surgery & Research: OTSR
Wei-Yuan Tsai, Ru-Yin Tsai, Chih-Chung Liu, Jia-Lin Wu, Chih-Shung Wong
We had previously demonstrated that excitatory amino acid glutamate plays a role in the progression and severity of knee osteoarthritis (OA), and early hyaluronic acid injection attenuates the OA progression by attenuation of knee joint glutamate level, which was also related to the cystine/glutamate antiporter system X (system XC-) expression. System XC- uptakes cystine into chondrocytes for glutathione (GSH) synthesis, but the role of system XC- in OA is rarely addressed. Sulfasalazine (SSZ) is a system XC- inhibitor; SSZ was applied intra-articularly to study the function of system XC- in the development of OA in rats subjected to anterior cruciate ligament transection and medial meniscectomy (ACLT + MMx)...
April 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Chih-Chung Liu, Li-Jen Su, Wei-Yuan Tsai, Hsiao-Lun Sun, Hoong-Chien Lee, Chih-Shung Wong
AIMS: The study was to examine the effect of Hylan G-F 20 on the progression of posttraumatic osteoarthritis (PTOA) and the expression of the circadian genes neuronal PAS domain protein 2 (NPAS2) and period 2 (Per2). MAIN METHODS: We used the anterior cruciate ligament transaction and medial menisectomy (ACLT+MMx) model in Wistar rats. The rats were divided into three groups, the sham-operated group, the Hylan G-F 20-treated group, and the saline-treated group. Rats which underwent ACLT + MMx surgery were injected intraarticularly with, respectively, Hylan G-F 20 or saline once a week for 3 consecutive weeks, starting 7days after surgery...
November 15, 2015: Life Sciences
Raymundo Cruz, Carmen Ramírez, Oscar I Rojas, Oscar Casas-Mejía, Juan B Kouri, Marco A Vega-López
Animal models have been used to understand the basic biology of osteoarthritis (OA) and have helped to identify new candidate biomarkers for the early diagnosis and treatment of this condition. Small animals cannot sufficiently mimic human diseases; therefore, large animal models are needed. Pigs have been used as models for human diseases because they are similar to humans in terms of their anatomy, physiology and genome. Hence, we analyzed articular cartilage and synovial membrane pathology in miniature Vietnamese pigs after a unilateral partial menisectomy and 20-day exercise regimen to determine if the pigs developed pathological characteristics similar to human OA...
November 2015: Pathology, Research and Practice
Feyza Unlu Ozkan, Gokcer Uzer, Ismail Türkmen, Yavuz Yildiz, Serkan Senol, Korhan Ozkan, Fatih Turkmensoy, Saime Ramadan, Ilknur Aktas
OBJECTIVE: The aim of this experimental study was to evaluate and compare the chondroprotective efficacy of intra-articular hyaluronic acid, tenoxicam and vitamin E in osteoarthritis. METHODS: An osteoarthritis model was created by anterior cruciate ligament transection and medial menisectomy in knees of 28 rats. The rats were randomized into four groups; first group served as a control group and received intra-articular injections of saline solution, intra-articular HA, intra-articular tenoxicam and intra-articular Vit E were applied to the treatment groups...
2015: International Journal of Clinical and Experimental Medicine
Yasser A Radwan, Atef A Alfeky, Mohammed F Faramawi
This work aimed to evaluate the analgesic efficacy of intra-articular injection of magnesium sulphate (4%) compared with equivalent volume of bupivacaine (0.5%) after outpatient knee arthroscopic meniscectomy. Forty patients were randomly assigned to two groups. Group M (n = 20) received intra-articular magnesium sulphate 4%, group B (n = 20) received bupivacaine (0.5%). Analgesic effect was evaluated by analgesic duration, and by measuring pain intensity at 1, 2, 4, 6, 12, 24 h both at rest and on knee movement to 90°...
July 2013: Journal of Advanced Research
Sherif A El Ghazaly, Amr A Abdul Rahman, Ahmed H Yusry, Mahmoud M Fathalla
PURPOSE: Meniscus injuries are the most commonly reported in athletes. Meniscectomy is the most common treatment. Stable peripheral tears may heal, while degenerative tears do well with physical therapy. However, the exact role of physical therapy in treating symptomatic unstable meniscal tears is not known. We aimed to identify the role of physical therapy in treating such patients and clarify the role of arthroscopic partial meniscectomy in treating unstable meniscal tears. METHODS: Seventy patients with unstable meniscal tear met the inclusion criteria according to Vande Berg and co-workers...
April 2015: International Orthopaedics
Veronica Mezhov, Andrew J Teichtahl, Rupert Strasser, Anita E Wluka, Flavia M Cicuttini
Whilst arthroscopic surgery for the treatment of meniscal tears is the most commonly performed orthopaedic surgery, meniscal tears at the knee are frequently identified on magnetic resonance imaging in adults with and without knee pain. The evidence for arthroscopic treatment of meniscal tears is controversial and lacks a supporting evidence base; it may be no more efficacious than conservative therapies. Surgical approaches to the treatment of meniscal pathology can be broadly categorised into those in which partial menisectomy or repair are performed...
2014: Arthritis Research & Therapy
Indira Prasadam, Yinghong Zhou, Wei Shi, Ross Crawford, Yin Xiao
OBJECTIVE: The aim of this study was to test the possible involvement, relevance and significance of dentin matrix protein 1 (DMP1) in chondrocyte redifferentiation and OA. METHODS: To examine the function of DMP1 in vitro, bone marrow stromal cells (BMSCs) and articular chondrocytes (ACs) were isolated and differentiated in micromasses in the presence or absence of DMP1 small interfering RNA and analysed for chondrogenic phenotype. The association of DMP1 expression with OA progression was analysed time dependently in the OA menisectomy rat model and in grade-specific OA human samples...
December 2014: Rheumatology
D J Blatz, R Fleming, J McCarroll
Over the past two years, 380 knee procedures have been reviewed to determine the number of suprapatellar plicas that were observed as contributing factors in the patello-femoral derangement problems of active duty personnel seen at the Naval Regional Medical Center in Charleston. Fiftyeight cases with a follow-up of greater than six months were found in which a suprapatellar plica was considered to be pathological, and was removed. The surgical cases involving a plicectomy, a plicectomy and partial chondrectomy of the patella, a plicectomy and menisectomy, or a plicectomy and extensor reconstruction of the patella were followed to determine whether the patients with these conditions returned to full active duty...
February 1, 1981: Orthopedics
Scott Cheatham, Morey J Kolber, William J Hanney
BACKGROUND: Patellar dislocations are traumatic injuries that occur most often in individuals under the age of twenty and are related to sports and physical activity. Currently, there are no published reports describing the rehabilitation of younger males after arthroscopy and open reconstruction of the medial patellofemoral ligament (MPFL) using a tibialis anterior allograft. CASE DESCRIPTION: The subject of this case report was a 23 year-old recreational male athlete who underwent right knee arthroscopic patellar chondroplasty, lateral retinacular release, partial lateral menisectomy, and an open MPFL reconstruction with a tibialis anterior allograft after sustaining a second patellar dislocation...
April 2014: International Journal of Sports Physical Therapy
Sonia Nasi, Hang-Korng Ea, Véronique Chobaz, Peter van Lent, Frédéric Lioté, Alexander So, Nathalie Busso
OBJECTIVES: The aim of our study was to evaluate the role of cell-membrane expressed TLRs and the signaling molecule MyD88 in a murine model of OA induced by knee menisectomy (surgical partial removal of the medial meniscus [MNX]). METHODS: OA was induced in 8-10weeks old C57Bl/6 wild-type (WT) female (n=7) mice and in knockout (KO) TLR-1 (n=7), -2 (n=8), -4 (n=9) -6 (n=5), MyD88 (n=8) mice by medial menisectomy, using the sham-operated contralateral knee as a control...
July 2014: Joint, Bone, Spine: Revue du Rhumatisme
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