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https://www.readbyqxmd.com/read/28526399/evaluation-of-the-effectiveness-of-chronic-antidepressant-drug-treatments-in-the-hippocampal-mitochondria-a-proteomic-study-in-an-animal-model-of-depression
#1
Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Rafał Olszanecki, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
Several lines of evidence indicate that adverse experience in early life may be a triggering factor for disturbances in the brain mitochondrial proteins and lead to the development of depression in adulthood. On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression. The purpose of our study was to compare the impact of chronic treatment with two antidepressant drugs with different mechanisms of action, a tricyclic antidepressant (TCA), imipramine, and an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, fluoxetine, on the mitochondria-enriched subproteome profile in the hippocampus of 3-month-old male rats following a prenatal stress procedure (an animal model of depression)...
May 16, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28523432/novel-t-cells-with-improved-in-vivo-anti-tumor-activity-generated-by-rna-electroporation
#2
Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Hua Li, Xuhua Zhang, Fuqin Zhang, Carl H June, Yangbing Zhao
The generation of T cells with maximal anti-tumor activities will significantly impact the field of T-cell-based adoptive immunotherapy. In this report, we found that OKT3/IL-2-stimulated T cells were phenotypically more heterogeneous, with enhanced anti-tumor activity in vitro and when locally administered in a solid tumor mouse model. To further improve the OKT3/IL-2-based T cell manufacturing procedure, we developed a novel T cell stimulation and expansion method in which peripheral blood mononuclear cells were electroporated with mRNA encoding a chimeric membrane protein consisting of a single-chain variable fragment against CD3 and the intracellular domains of CD28 and 4-1BB (OKT3-28BB)...
May 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28522346/seeing-in-the-dark-phosphene-thresholds-with-eyes-open-versus-closed-in-the-absence-of-visual-inputs
#3
T A de Graaf, F Duecker, Y Stankevich, S Ten Oever, A T Sack
BACKGROUND: Voluntarily opening or closing our eyes results in fundamentally different input patterns and expectancies. Yet it remains unclear how our brains and visual systems adapt to these ocular states. OBJECTIVE/HYPOTHESIS: We here used transcranial magnetic stimulation (TMS) to probe the excitability of the human visual system with eyes open or closed, in the complete absence of visual inputs. METHODS: Combining Bayesian staircase procedures with computer control of TMS pulse intensity allowed interleaved determination of phosphene thresholds (PT) in both conditions...
May 3, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28520900/accelerating-high-dimensional-clustering-with-lossless-data-reduction
#4
Bahjat F Qaqish, Jonathon J O'Brien, Jonathan C Hibbard, Katie J Clowers
Motivation: For cluster analysis, high dimensional data is associated with instability, decreased classification accuracy and high computational burden. The latter challenge can be eliminated as a serious concern. For applications where dimension reduction techniques are not implemented, we propose a temporary transformation which accelerates computations with no loss of information. The algorithm can be applied for any statistical procedure depending only on Euclidean distances and can be implemented sequentially to enable analyses of data that would otherwise exceed memory limitations...
May 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28507514/markovian-analysis-of-the-sequential-behavior-of-the-spontaneous-spinal-cord-dorsum-potentials-induced-by-acute-nociceptive-stimulation-in-the-anesthetized-cat
#5
Mario Martin, Javier Béjar, Gennaro Esposito, Diógenes Chávez, Enrique Contreras-Hernández, Silvio Glusman, Ulises Cortés, Pablo Rudomín
In a previous study we developed a Machine Learning procedure for the automatic identification and classification of spontaneous cord dorsum potentials (CDPs). This study further supported the proposal that in the anesthetized cat, the spontaneous CDPs recorded from different lumbar spinal segments are generated by a distributed network of dorsal horn neurons with structured (non-random) patterns of functional connectivity and that these configurations can be changed to other non-random and stable configurations after the noceptive stimulation produced by the intradermic injection of capsaicin in the anesthetized cat...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28507033/response-specific-sex-difference-in-the-retention-of-fear-extinction
#6
Meagan E Voulo, Ryan G Parsons
Fear conditioning studies in rodents allow us to assess vulnerability factors which might underlie fear-based psychopathology such as post-traumatic stress disorder (PTSD). Despite PTSD being more prevalent in females than males, very few fear conditioning studies in rodents have tested females. Our study assessed fear conditioning and extinction in male and female rats using both fear-potentiated startle and freezing behavior as measures. Rats were trained to fear cues that predicted the occurrence of shock and then subsequently exposed to an extinction training procedure where the cue was presented repeatedly in the absence of shock...
June 2017: Learning & Memory
https://www.readbyqxmd.com/read/28505440/iterative-reconstruction-of-memory-kernels
#7
Gerhard Jung, Martin Hanke, Friederike Schmid
In recent years it has become increasingly popular to construct coarse-grained models with non-Markovian dynamics in order to account for an incomplete separation of time scales. One challenge of a systematic coarse-graining procedure is the extraction of the dynamical properties, namely the memory kernel, from equilibrium all-atom simulations. In this paper we propose an iterative method for memory reconstruction from dynamical correlation functions. Compared to previously proposed non-iterative techniques, it ensures by construction that the target correlation functions of the original fine-grained systems are reproduced accurately by the coarse-grained system, regardless of time step and discretization effects...
May 15, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28499576/an-introduction-to-the-model-of-crisis-intervention-procedure-for-borderline-patients-cip-bp-a-case-study
#8
Tytus Koweszko, Jacek Gierus, Magdalena Więdłocha, Anna Mosiołek, Agata Szulc
Borderline personality disorder is highly associated with suicidal behaviors. The authors of the current case study present the introduction model of original Crisis Intervention Procedure for Borderline Patients (CIP-BP) which is a method focused on restoring emotional balance, reducing the severity of symptoms and the risk of suicidal behavior, as well as developing optimum solutions for further action. Its aim is to enable the patient to regain control of their emotional memory, increase autonomy and restore important interpersonal relations by using the original resources of this person...
June 2017: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/28495598/mental-arithmetic-in-the-bilingual-brain-language-matters
#9
Amandine Van Rinsveld, Laurence Dricot, Mathieu Guillaume, Bruno Rossion, Christine Schiltz
How do bilinguals solve arithmetic problems in each of their languages? We investigated this question by exploring the neural substrates of mental arithmetic in bilinguals. Critically, our population was composed of a homogeneous group of adults who were fluent in both of their instruction languages (i.e., German as first instruction language and French as second instruction language). Twenty bilinguals were scanned with fMRI (3T) while performing mental arithmetic. Both simple and complex problems were presented to disentangle memory retrieval occuring in very simple problems from arithmetic computation occuring in more complex problems...
May 8, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28493407/first-person-perspective-video-to-enhance-simulation
#10
Junaid Fukuta, Justin Morgan
BACKGROUND: Simulation training is increasingly being used as part of the undergraduate medical curriculum, but it remains time and faculty member intensive. To improve efficacy, videos have been used prior to the simulation of practical procedures; however, using videos prior to simulation training concerning the management of patients who are unwell has not been investigated. The aim of this project was to see whether clinical decision-making and non-technical skills can be improved if a video is used prior to simulation training, and uniquely to enhance the authenticity we filmed it using a first-person perspective...
May 10, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28493404/accuracy-of-finite-difference-harmonic-frequencies-in-density-functional-theory
#11
Kuan-Yu Liu, Jie Liu, John M Herbert
Analytic Hessians are often viewed as essential for the calculation of accurate harmonic frequencies, but the implementation of analytic second derivatives is nontrivial and solution of the requisite coupled-perturbed equations engenders a sizable memory footprint for large systems, given that these equations are not required for energy and gradient calculations in density functional theory. Here, we benchmark the alternative approach to harmonic frequencies based on finite differences of analytic first derivatives, a procedure that is amenable to large-scale parallelization...
May 10, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28482463/nanoencapsulation-of-lutein-and-its-effect-on-mice-s-declarative-memory
#12
Jéssica Thaís do Prado Silva, Júlia Maria Tonin Geiss, Sara Marchesan Oliveira, Evelyne da Silva Brum, Sara Cristina Sagae, Daniela Becker, Fernanda Vitória Leimann, Rafael Porto Ineu, Gustavo Petri Guerra, Odinei Hess Gonçalves
Lutein is a xanthophyll carotenoid widely known by its biological properties and low toxicity. When located in the brain, lutein may inhibit damage mechanisms, acting in neural cells maintenance. However, this carotenoid is very sensitive to external agents such as heat, light, pH and oxidation, besides presenting low absorption in gastrointestinal tract due its low solubility in water. Encapsulation procedures have shown promising results to increase lutein stability and bioavailability. In this work, lutein was encapsulated in polyvinylpyrrolidone (PVP) matrix by the dissolution in common solvent method...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28478769/long-term-outcome-after-percutaneous-closure-of-persistent-left-superior-caval-vein-draining-into-the-left-atrium-a-contrast-enhanced-ct-study
#13
Davide Marini, Matteo Castagno, Michele Millesimo, Francesca Ferroni, Gaetana Ferraro, Carlo Pace Napoleone, Gabriella Agnoletti
BACKGROUND: Data regarding long-term outcome after percutaneous closure of left superior caval vein draining into the left atrium are lacking. The aim of the present study was to report the long-term follow-up by using contrast-enhanced CT. METHODS: In all, three patients underwent percutaneous closure of left superior caval vein draining into the left atrium between 2005 and 2015. All of them were evaluated clinically and underwent contrast-enhanced CT. RESULTS: In one patient, the Amplatzer® Septal Occluder was used...
May 8, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28477077/immunophenotyping-as-a-new-tool-for-classification-and-monitoring-of-systemic-autoimmune-diseases
#14
Yves Renaudineau
The clinical course of systemic autoimmune diseases (SADs) varies greatly, even between individuals with the same disease. Understanding of the immune actors is informative and could lead to significant improvements in diagnosis, monitoring, initial treatment decisions and/or follow-up. However, immunological changes in mononuclear cells associated with SADs have been only partially described, and usually are limited to analysis of peripheral blood cells (less than 5% of the total mononuclear pool). Another limitation is technological, related to utilization of flow cytometry, which remains highly variable with regards to sample preparation, reagents, instrument constraints, and data analysis...
May 5, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28476108/diaphragmatic-surgery-and-related-complications-in-primary-cytoreduction-for-advanced-ovarian-tubal-and-peritoneal-carcinoma
#15
Shuang Ye, Tiancong He, Shanhui Liang, Xiaojun Chen, Xiaohua Wu, Huijuan Yang, Libing Xiang
BACKGROUND: To evaluate the procedures and complications of diaphragm peritonectomy (DP) and diaphragm full-thickness resection (DFTR) during primary cytoreduction for advanced stage epithelial ovarian cancer. METHODS: All the patients with epithelial ovarian carcinoma who underwent diaphragm procedures at our institution between January 2009 and August 2015 were identified. Clinicopathological data were retrospectively collected from the patients' medical records...
May 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28472397/olelo-a-web-application-for-intuitive-exploration-of-biomedical-literature
#16
Milena Kraus, Julian Niedermeier, Marcel Jankrift, Sören Tietböhl, Toni Stachewicz, Hendrik Folkerts, Matthias Uflacker, Mariana Neves
Researchers usually query the large biomedical literature in PubMed via keywords, logical operators and filters, none of which is very intuitive. Question answering systems are an alternative to keyword searches. They allow questions in natural language as input and results reflect the given type of question, such as short answers and summaries. Few of those systems are available online but they experience drawbacks in terms of long response times and they support a limited amount of question and result types...
May 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28458824/vertebral-artery-dissection-following-a-posterior-cervical-foraminotomy
#17
Aniruddha A Sheth, Stephen Honeybul
Vertebral artery dissection following a posterior cervical foraminotomy with rhizolysis of the subaxial spine has not been described before. A 46-year-old lady underwent the procedure for a left C6 radiculopathy with a focal disc herniation with no intraoperative complications. Seven hours post-operatively, she developed a right homonymous hemianopia, thalamic dysphasia, gait and memory impairment. Imaging demonstrated an occlusion to the left vertebral artery from C7/T1 to C4 with a dissection flap noted at the inferior margin...
February 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28456203/coarse-graining-strategy-for-molecular-pair-interactions-a-reaction-coordinate-study-for-two-and-three-dimensional-systems
#18
Thomas Heinemann, Sabine H L Klapp
We investigate and provide optimal sets of reaction coordinates for mixed pairs of molecules displaying polar, uniaxial, or spherical symmetry in two and three dimensions. These coordinates are non-redundant, i.e., they implicitly involve the molecules' symmetries. By tabulating pair interactions in these coordinates, resulting tables are thus minimal in length and require a minimal memory space. The intended fields of application are computer simulations of large ensembles of molecules or colloids with rather complex interactions in a fluid or liquid crystalline phase at low densities...
April 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28453969/reducing-intrusive-traumatic-memories-after-emergency-caesarean-section-a-proof-of-principle-randomized-controlled-study
#19
Antje Horsch, Yvan Vial, Céline Favrod, Mathilde Morisod Harari, Simon E Blackwell, Peter Watson, Lalitha Iyadurai, Michael B Bonsall, Emily A Holmes
Preventative psychological interventions to aid women after traumatic childbirth are needed. This proof-of-principle randomized controlled study evaluated whether the number of intrusive traumatic memories mothers experience after emergency caesarean section (ECS) could be reduced by a brief cognitive intervention. 56 women after ECS were randomized to one of two parallel groups in a 1:1 ratio: intervention (usual care plus cognitive task procedure) or control (usual care). The intervention group engaged in a visuospatial task (computer-game 'Tetris' via a handheld gaming device) for 15 min within six hours following their ECS...
April 6, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28447764/sevoflurane-anesthesia-in-pregnant-rats-negatively-affects-nerve-function-in-offspring-potentially-via-inhibition-of-the-wnt-%C3%AE-catenin-pathway
#20
Yiyao Wang, Yu Li, Qunzhi Xing, Xuechan G Han, Xu Dong, Yiping Lu, Mintao Zhou
Due to the rapid development of medical technology used to perform intrauterine procedures during pregnancy, the number of patients receiving fetal surgery under general anesthesia is increasing. The aim of the present study was to determine the effects of anesthetics on the offspring of rats, and to identify the potential mechanisms underlying these effects. On day 14 of pregnancy, Sprague‑Dawley rats were equally divided into the following 3 groups (n=9): Control group (n=3), 3% sevoflurane group (n=3) and 4% sevoflurane group (n=3)...
May 2017: Molecular Medicine Reports
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