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Dopamine and working memory

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https://www.readbyqxmd.com/read/29658920/identification-of-dopamine-d1-alpha-receptor-within-rodent-nucleus-accumbens-by-an-innovative-rna-in-situ-detection-technology
#1
Hailong Li, Jessica M Illenberger, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booze
In the central nervous system, the D1-alpha subtype receptor (Drd1α) is the most abundant dopamine (DA) receptor, which plays a vital role in regulating neuronal growth and development. However, the mechanisms underlying Drd1α receptor abnormalities mediating behavioral responses and modulating working memory function are still unclear. Using a novel RNA in situ hybridization assay, the current study identified dopamine Drd1α receptor and tyrosine hydroxylase (TH) RNA expression from DA-related circuitry in the nucleus accumbens (NAc) area and substantia nigra region (SNR), respectively...
March 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29629245/selective-attention-on-representations-in-working-memory-cognitive-and-neural-mechanisms
#2
Yixuan Ku
Selective attention and working memory are inter-dependent core cognitive functions. It is critical to allocate attention on selected targets during the capacity-limited working memory processes to fulfill the goal-directed behavior. The trends of research on both topics are increasing exponentially in recent years, and it is considered that selective attention and working memory share similar underlying neural mechanisms. Different types of attention orientation in working memory are introduced by distinctive cues, and the means using retrospective cues are strengthened currently as it is manipulating the representation in memory, instead of the perceptual representation...
2018: PeerJ
https://www.readbyqxmd.com/read/29623644/intranasal-instillation-of-iron-oxide-nanoparticles-induces-inflammation-and-perturbation-of-trace-elements-and-neurotransmitters-but-not-behavioral-impairment-in-rats
#3
Dalel Askri, Souhir Ouni, Said Galai, Josiane Arnaud, Benoit Chovelon, Sylvia G Lehmann, Nathalie Sturm, Mohsen Sakly, Michel Sève, Salem Amara
Over the last decades, engineered nanomaterials have been widely used in various applications due to their interesting properties. Among them, iron oxide nanoparticles (IONPs) are used as theranostic agents for cancer, and also as contrast agents in magnetic resonance imaging. With the increasing production and use of these IONPs, there is an evident raise of IONP exposure and subsequently a higher risk of adverse outcome for humans and the environment. In this work, we aimed to investigate the effects of sub-acute IONP exposure on Wistar rat, particularly (i) on the emotional and learning/memory behavior, (ii) on the hematological and biochemical parameters, (iii) on the neurotransmitter content, and (vi) on the trace element homeostasis...
April 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29599495/multilocus-genetic-profile-in-dopaminergic-pathway-modulates-the-striatum-and-working-memory
#4
Chao Wang, Bing Liu, Xiaolong Zhang, Yue Cui, Chunshui Yu, Tianzi Jiang
Dopamine is critical in pathophysiology and therapy of schizophrenia. Many studies have reported altered dopaminergic activity in the dorsal but not ventral striatum in schizophrenia. Based on the largest genome-wide association study of schizophrenia to date, we calculated the polygenic risk score (PGRS) of each subject in a healthy general group, including all variations in the set of functionally related genes involved in dopamine neurotransmitter system. We aimed to test whether the genetic variations in the dopaminergic pathway that have been identified as associated with schizophrenia are related to the function of the striatum and to working memory...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29569219/dopamine-d2-agonist-affects-visuospatial-working-memory-distractor-interference-depending-on-individual-differences-in-baseline-working-memory-span
#5
James M Broadway, Michael J Frank, James F Cavanagh
The interplay of dopaminergic striatal D1-D2 circuits is thought to support working memory (WM) by selectively filtering information that is to be remembered versus information to be ignored. To test this theory, we conducted an experiment in which healthy participants performed a visuospatial working memory (VSWM) task after ingesting the D2-receptor agonist cabergoline (or placebo), in a randomized, double-blinded, crossover design. Results showed greater interference from distractors under cabergoline, particularly for individuals with higher baseline dopamine (indicated by WM span)...
March 22, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29567584/interaction-between-striatal-volume-and-dat1-polymorphism-predicts-working-memory-development-during-adolescence
#6
F Nemmi, C Nymberg, F Darki, T Banaschewski, A L W Bokde, C Büchel, H Flor, V Frouin, H Garavan, P Gowland, A Heinz, J-L Martinot, F Nees, T Paus, M N Smolka, T W Robbins, G Schumann, T Klingberg
There is considerable inter-individual variability in the rate at which working memory (WM) develops during childhood and adolescence, but the neural and genetic basis for these differences are poorly understood. Dopamine-related genes, striatal activation and morphology have been associated with increased WM capacity after training. Here we tested the hypothesis that these factors would also explain some of the inter-individual differences in the rate of WM development. We measured WM performance in 487 healthy subjects twice: at age 14 and 19...
March 13, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29560440/chronic-voluntary-oral-methamphetamine-induces-deficits-in-spatial-learning-and-hippocampal-protein-kinase-mzeta-with-enhanced-astrogliosis-and-cyclooxygenase-2-levels
#7
Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serrano
Methamphetamine (MA) is an addictive drug with neurotoxic effects on the brain producing cognitive impairment and increasing the risk for neurodegenerative disease. Research has focused largely on examining the neurochemical and behavioral deficits induced by injecting relatively high doses of MA [30 mg/kg of body weight (bw)] identifying the upper limits of MA-induced neurotoxicity. Accordingly, we have developed an appetitive mouse model of voluntary oral MA administration (VOMA) based on the consumption of a palatable sweetened oatmeal mash containing a known amount of MA...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29544881/reward-sensitivity-in-parkinson-s-patients-with-binge-eating
#8
Damiano Terenzi, Raffaella I Rumiati, Mauro Catalan, Lucia Antonutti, Giovanni Furlanis, Paolo Garlasco, Paola Polverino, Claudio Bertolotti, Paolo Manganotti, Marilena Aiello
BACKGROUND: Parkinson's disease (PD) patients who are treated with dopamine replacement therapy are at risk of developing impulse control disorders (ICDs) (such as gambling, binge eating, and others). According to recent evidence, compulsive reward seeking in ICDs may arise from an excessive attribution of incentive salience (or 'wanting') to rewards. OBJECTIVES: In this study, we tested this hypothesis in patients with PD who developed binge eating (BE). METHODS: Patients with BE, patients without BE, and healthy controls performed different experimental tasks assessing food liking and wanting...
March 9, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29540721/dopamine-d1-receptor-density-in-the-mpfc-responds-to-cognitive-demands-and-receptor-turnover-contributes-to-general-cognitive-ability-in-mice
#9
Christopher Wass, Bruno Sauce, Alessandro Pizzo, Louis D Matzel
In both humans and mice, performance on tests of intelligence or general cognitive ability (GCA) is related to dopamine D1 receptor-mediated activity in the prelimbic cortex, and levels of DRD1 mRNA predict the GCA of mice. Here we assessed the turnover rate of D1 receptors as well as the expression level of the D1 chaperone protein (DRiP78) in the medial PPC (mPFC) of mice to determine whether rate of receptor turnover was associated with variations in the GCA of genetically heterogeneous mice. Following assessment of GCA (aggregate performance on four diverse learning tests) mice were administered an irreversible dopamine receptor antagonist (EEDQ), after which the density of new D1 receptors were quantified...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29526657/effect-of-striatal-dopamine-depletion-on-cognition-in-de-novo-parkinson-s-disease
#10
Seok Jong Chung, Han Soo Yoo, Jungsu S Oh, Jae Seung Kim, Byoung Seok Ye, Young H Sohn, Phil Hyu Lee
INTRODUCTION: To investigate the relationship between the sub-regional pattern of striatal dopamine depletion and cognitive impairment in early-stage Parkinson's disease (PD), and determine the effect of striatal dopamine density on cognitive prognosis. METHODS: Patients with drug-naïve non-demented PD were divided into mild cognitive impairment (PD-MCI; n = 129) and cognitively normal (PD-CogN; n = 182) groups. Using quantification of the dopamine transporter (DAT) availability in each striatal sub-region with18 F-FP-CIT PET scans, we performed inter-group comparative analysis of DAT availability and multivariate linear regression analysis to assess the association between DAT availability and cognitive performance...
March 2, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29524644/dopamine-suppresses-persistent-firing-in-layer-iii-lateral-entorhinal-cortex-neurons
#11
Ariel A Batallán-Burrowes, C Andrew Chapman
Persistent firing in layer III entorhinal cortex neurons that can be evoked during muscarinic receptor activation may contribute to mechanisms of working memory. The entorhinal cortex receives strong dopaminergic inputs which may modulate working memory for motivationally significant information. We used whole cell recordings in in vitro rat brain slices to assess the effects of dopamine on persistent firing in layer III neurons initiated by depolarizing current injection. Persistent firing during pharmacological block of ionotropic excitatory and inhibitory synaptic transmission, and in the presence of the cholinergic agonist carbachol (10 μM), was observed in 39% of layer III pyramidal cells...
March 7, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29501506/do-trpc-channels-support-working-memory-comparing-modulations-of-trpc-channels-and-working-memory-through-g-protein-coupled-receptors-and-neuromodulators
#12
REVIEW
Antonio Reboreda, Frederik M Theissen, Maria Valero-Aracama, Alberto Arboit, Mihaela A Corbu, Motoharu Yoshida
Working memory is a crucial ability we use in daily life. However, the cellular mechanisms supporting working memory still remain largely unclear. A key component of working memory is persistent neural firing which is believed to serve short-term (hundreds of milliseconds up to tens of seconds) maintenance of necessary information. In this review, we will focus on the role of transient receptor potential canonical (TRPC) channels as a mechanism underlying persistent firing. Many years of in vitro work have been suggesting a crucial role of TRPC channels in working memory and temporal association tasks...
March 1, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29478701/dopamine-d-1-receptor-positive-neurons-in-the-lateral-nucleus-of-the-cerebellum-contribute-to-cognitive-behavior
#13
Timothy M Locke, Marta E Soden, Samara M Miller, Avery Hunker, Cerise Knakal, Julia A Licholai, Karn S Dhillon, C Dirk Keene, Larry S Zweifel, Erik S Carlson
BACKGROUND: Studies in humans and nonhuman primates have identified a region of the dentate nucleus of the cerebellum, or the lateral cerebellar nucleus (LCN) in rodents, activated during performance of cognitive tasks involving complex spatial and sequential planning. Whether such a subdivision exists in rodents is not known. Dopamine and its receptors, which are implicated in cognitive function, are present in the cerebellar nuclei, but their function is unknown. METHODS: Using viral and genetic strategies in mice, we examined cellular phenotypes of dopamine D1 receptor-positive (D1R+) cells in the LCN with whole-cell patch clamp recordings, messenger RNA profiling, and immunohistochemistry to examine D1R expression in mouse LCN and human dentate nucleus of the cerebellum...
February 2, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29415163/genetic-variation-of-a-drd2-co-expression-network-is-associated-with-changes-in-prefrontal-function-after-d2-receptors-stimulation
#14
Pierluigi Selvaggi, Giulio Pergola, Barbara Gelao, Pasquale Di Carlo, Maria Antonietta Nettis, Graziella Amico, Leonardo Fazio, Antonio Rampino, Fabio Sambataro, Giuseppe Blasi, Alessandro Bertolino
Dopamine D2 receptors (D2Rs) contribute to the inverted U-shaped relationship between dopamine signaling and prefrontal function. Genetic networks from post-mortem human brain revealed 84 partner genes co-expressed with DRD2. Moreover, eight functional single nucleotide polymorphisms combined into a polygenic co-expression index (PCI) predicted co-expression of this DRD2 network and were associated with prefrontal function in humans. Here, we investigated the non-linear association of the PCI with behavioral and Working Memory (WM) related brain response to pharmacological D2Rs stimulation...
February 3, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29410219/dopaminergic-modulation-of-hemodynamic-signal-variability-and-the-functional-connectome-during-cognitive-performance
#15
Mohsen Alavash, Sung-Joo Lim, Christiane Thiel, Bernhard Sehm, Lorenz Deserno, Jonas Obleser
Dopamine underlies important aspects of cognition, and has been suggested to boost cognitive performance. However, how dopamine modulates the large-scale cortical dynamics during cognitive performance has remained elusive. Using functional MRI during a working memory task in healthy young human listeners, we investigated the effect of levodopa (l-dopa) on two aspects of cortical dynamics, blood oxygen-level-dependent (BOLD) signal variability and the functional connectome of large-scale cortical networks. We here show that enhanced dopaminergic signaling modulates the two potentially interrelated aspects of large-scale cortical dynamics during cognitive performance, and the degree of these modulations is able to explain inter-individual differences in l-dopa-induced behavioral benefits...
February 2, 2018: NeuroImage
https://www.readbyqxmd.com/read/29391391/a-systematic-review-of-the-role-of-the-nociceptin-receptor-system-in-stress-cognition-and-reward-relevance-to-schizophrenia
#16
REVIEW
Muhammad Saad Khan, Isabelle Boileau, Nathan Kolla, Romina Mizrahi
Schizophrenia is a debilitating neuropsychiatric illness that is characterized by positive, negative, and cognitive symptoms. Research over the past two decades suggests that the nociceptin receptor system may be involved in domains affected in schizophrenia, based on evidence aligning it with hallmark features of the disorder. First, aberrant glutamatergic and striatal dopaminergic function are associated with psychotic symptoms, and the nociceptin receptor system has been shown to regulate dopamine and glutamate transmission...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29377353/blockade-of-dopamine-d2-receptors-disrupts-intrahippocampal-connectivity-and-enhances-pain-related-working-memory-deficits-in-neuropathic-pain-rats
#17
H Cardoso-Cruz, M Dourado, C Monteiro, V Galhardo
BACKGROUND: Dopamine (DA) is thought to be important to local hippocampal networks integrity during spatial working memory (sWM) processing. Chronic pain may contribute to deficient dopaminergic signalling, which may in turn affect cognition. However, the neural mechanisms that determine this impairment are poorly understood. Here, we evaluated whether the sWM impairment characteristic of animal models of chronic pain is dependent on DA D2 receptor (D2r) activity. METHODS: To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 field (dvCA1) of rats and recorded the neuronal activity during a classical delayed food-reinforced T-maze sWM task...
January 26, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29348190/pronounced-hyperactivity-cognitive-dysfunctions-and-bdnf-dysregulation-in-dopamine-transporter-knock-out-rats
#18
Damiana Leo, Ilya Sukhanov, Francesca Zoratto, Placido Illiano, Lucia Caffino, Fabrizio Sanna, Giulia Messa, Marco Emanuele, Alessandro Esposito, Mariia Dorofeikova, Evgeny A Budygin, Liudmila Mus, Evgenia V Efimova, Marco Niello, Stefano Espinoza, Tatyana D Sotnikova, Marius C Hoener, Giovanni Laviola, Fabio Fumagalli, Walter Adriani, Raul R Gainetdinov
Dopamine (DA) controls many vital physiological functions and is critically involved in several neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder. The major function of the plasma membrane dopamine transporter (DAT) is the rapid uptake of released DA into presynaptic nerve terminals leading to control of both the extracellular levels of DA and the intracellular stores of DA. Here, we present a newly developed strain of rats in which the gene encoding DAT knockout Rats (DAT-KO) has been disrupted by using zinc finger nuclease technology...
February 21, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29310263/facile-synthesis-of-near-infrared-excited-nayf-4-yb-3-tm-3-nanoparticles-for-label-free-detection-of-dopamine-in-biological-fluids
#19
Bing Zhao, Yan Li
Rare-earth-doped upconversion nanoparticles (UCNPs) behaved advantages such as non-autofluorescence, environment-friendly synthetic route, low cost and simple detection procedures. In addition, the UCNPs show unique upconvering optical property of converting low-energy infrared photons to high-energy visible ones. Here in our work, water and ethylene glycol at the ratio of 1/1 (v/v) were chosen as solvent. Polyethyleneimine (PEI) was chosen as surface additives to synthesize the NaYF4 :Yb3+ , Tm3+ UCNPs by one-pot route at 200°C...
March 1, 2018: Talanta
https://www.readbyqxmd.com/read/29259546/neither-cholinergic-nor-dopaminergic-enhancement-improve-spatial-working-memory-precision-in-humans
#20
Adeola N Harewood Smith, Jnana Aditya Challa, Michael A Silver
Acetylcholine and dopamine are neurotransmitters that play multiple important roles in perception and cognition. Pharmacological cholinergic enhancement reduces excitatory receptive field size of neurons in marmoset primary visual cortex and sharpens the spatial tuning of visual perception and visual cortical fMRI responses in humans. Moreover, previous studies show that manipulation of cholinergic or dopaminergic signaling alters the spatial tuning of macaque prefrontal cortical neurons during the delay period of a spatial working memory (SWM) task and can improve SWM performance in macaque monkeys and human subjects...
2017: Frontiers in Neural Circuits
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