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Daniel V Guebel, Néstor V Torres
Motivation: In the brain of elderly-healthy individuals, the effects of sexual dimorphism and those due to normal aging appear overlapped. Discrimination of these two dimensions would powerfully contribute to a better understanding of the etiology of some neurodegenerative diseases, such as "sporadic" Alzheimer. Methods: Following a system biology approach, top-down and bottom-up strategies were combined. First, public transcriptome data corresponding to the transition from adulthood to the aging stage in normal, human hippocampus were analyzed through an optimized microarray post-processing (Q-GDEMAR method) together with a proper experimental design (full factorial analysis)...
2016: Frontiers in Aging Neuroscience
Hnin Hnin Aung, Robin Altman, Tun Nyunt, Jeffrey Kim, Saivageethi Nuthikattu, Madhu Budamagunta, John C Voss, Dennis Wilson, John C Rutledge, Amparo C Villablanca
Dysfunction of the cerebrovasculature plays an important role in vascular cognitive impairment (VCI). Lipotoxic injury of the systemic endothelium in response to hydrolyzed triglyceride-rich lipoproteins (TGRLs; TGRL lipolysis products) or a high-fat Western diet (WD) suggests similar mechanisms may be present in brain microvascular endothelium. We investigated the hypothesis that TGRL lipolysis products cause lipotoxic injury to brain microvascular endothelium by generating increased mitochondrial superoxide radical generation, upregulation of activating transcription factor 3 (ATF3)-dependent inflammatory pathways, and activation of cellular oxidative stress and apoptotic pathways...
June 2016: Journal of Lipid Research
Paola Iannetti, Laura Papetti, Francesco Nicita, Antonella Castronovo, Fabiana Ursitti, Pasquale Parisi, Alberto Spalice, Alberto Verrotti
INTRODUCTION: The maldevelopment of the midline structures is connected with neurologic disorders. The cavum septum pellucidum (CSP) exists in the fetal period, then it is re-absorbed. The presence of unfused leaflets/fornices may be considered important in the genesis of neurodevelopmental abnormalities inclunding epilepsy. The limbic system includes a group of interconnected gray and white matter structures; in this circuit, the fornix is an important white matter connection with the septum pellucidum...
May 2011: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
E B Arushanian, E V Beĭer
No abstract text is available yet for this article.
2007: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Ernesto Roldán-Valadez, Roberto Corona-Cedillo, Juan Cosme-Labarthe, Manuel Martínez-López
Recent studies show that up to 70% of patients with temporal lobe epilepsy (TLE) have a hippocampal deficit known as temporal mesial sclerosis (TME) characterized by neuron loss and gliosis, and considered the main epileptogenic focus among this type of patients. The magnetic resonance imaging (MRI) features of TME include atrophy and hippocampus hyperintensitY in the long TR sequences (Flair and T2). The 3.0 Tesla MRI allows the study of the brain's anatomy and physiology using different sequences and post processing mechanisms...
September 2007: Gaceta Médica de México
O V Severynovs'ka, M O Hryhorova, O Iu Zaĭchenko, K I Kasymova, A I Dvorets'kyĭ, V K Rybal'chenko
The influence of heavy metals salts mix, the most widespread pollutants of Prydnieprovsky region natural reservoirs on animal behavioral reactions, memory processes and total bioelectric activity of various brain departments has been investigated. It was revealed that heavy metals consumption with drinking water results in the development of the neurotization processes, at that due to animals hyperactivity there is an exhaustion of nervous centers that is reflected by prolongation of immobility periods in animals...
2007: Fiziolohichnyĭ Zhurnal
I V Pavlova, G L Vanetsian
By plotting autocorrelation histograms, the character of impulsation of neurons in bilateral derivations from cortical visual and somatosensory areas and hippocampal field CA1 was studied in rabbits during free behavior under the influences of emotional stimuli. During active orienting-exploratory reaction of rabbits, most cortical and hippocampal neurons manifested bursting discharges and theta-frequency oscillation (predominantly 4-5 Hz in cortex and 4-5, 6-7 in hyppocampus). During freezing, as compared with active locomotor reaction, the number of neurons with equiprobabilistic discharges increased; in impulsation of neurons with periodicity, the intensity of delta-frequency oscillation increased (predominantly 2-4 Hz) but theta-frequency oscillation decreased...
November 2006: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Maria Addolorata Saracino, Ottavio Gandolfi, Rossella Dall'olio, Lawrence Albers, Ernst Kenndler, Maria Augusta Raggi
A sensitive and selective method was developed for the determination of the antipsychotic drug Olanzapine levels in rat brain tissue, based on HPLC with electrochemical detection. The analyses were carried out on a C8 reversed phase column (150 mm x 4.6 mm, 5 microm), using a mobile phase composed of methanol and a phosphate buffer (44.0 mM, pH 3.5), containing triethylamine (21:79, v/v), flowing at 1.2 mL min(-1). A high sensitivity coulometric detection analytical cell containing two flow-through low volume working electrodes was used: electrode 1 was set at +0...
July 28, 2006: Journal of Chromatography. A
J Morales-Montor, C Larralde
Sex steroids play a significant role in regulating the parasite load in experimental intraperitoneal Taenia crassiceps cysticercosis of male and female Balbc/anN mice. Briefly, oestrogens increase parasite loads and androgens decrease them (1) by acting directly on the parasite, favouring or hindering its reproduction, respectively, and (2) by biasing the hosts' immune response towards a parasite-permissive Th2 or a parasite-restrictive Th1 response. The infected male host also undergoes drastic endocrinological and behavioural changes that may impinge upon the course of infection, and the host's mating behaviour and its exposure to predators...
September 2005: Parasitology
T M Myshunina, V Ia Kononenko, N I Levchuk
The reaction of the rat adrenal cortex and medulla to stress was absent under conditions of compensatory activations of function of hypothalamic-pituitary-adrenal system. At the same time, glutamate decarboxylase activity was increased in the hypothalamus, decreased in the hyppocampus, and remained unchanged in medulla oblongata and cortex of cerebral hemispheres of hemiadrenalectomized rats after stress as compared to rats without stress. On the contrary, the intensity of specific GABA binding by synaptic membranes of medulla oblongata of hemiadrenalectomized rats was increased in response to stress effect it was decreased in the cortex of cerebral hemispheres, and remained unchanged in the hyppocampus...
March 2004: Ukraïnsʹkyĭ Biokhimichnyĭ Z︠h︡urnal
F Madiai, K Hackshaw
The mouse Fgf-1 gene contains at least four upstream promoters that are alternatively spliced to the first protein coding exon, giving rise to different Fgf-1 mRNA variants (1.A, 1.B, 1.C, and 1.G), each expressed in a tissue specific manner. Only the Fgf-1.A promoter contains TATA and CAAT consensus sequences, and its corresponding mRNA is mainly expressed in the mouse heart. In situ hybridization with an Fgf-1.A-specific cRNA probe showed the 1.A message to be very low in embryonic heart, tongue, spinal cord and smooth muscle of the small intestine...
2002: Research Communications in Molecular Pathology and Pharmacology
Ke-wen Jiang, Ying Zhang, Quan-xiang Shui
OBJECTIVE: To explore the possible mechanism of electroacupuncture preconditioning (EAPC) and combined with ATP-sensitive potassium channel (KATP) blocker preconditioning for hypoxia/ischemic brain injury protection by observing the changes of the immediate genes (c-fos and c-jun protein content) in brain at the early stage after cerebral hypoxia/ischemic injury, and the effect of EAPC on these changes. METHODS: Integrated density (ID) of c-fos and c-jun expression was measured by Western blot and computerized image processing...
December 2003: Chinese Journal of Integrated Traditional and Western Medicine
V M Trindade, J L Daniotti, L Raimondi, R Chazan, C A Netto, H J Maccioni
Neonatal Hypoxia-Ischemia (HI) triggers a cascade of biochemical events that result in neuronal injury, but the mechanisms underlying these processes are not completely understood, and information regarding the effect of HI on the synthesis of brain glycoconjugates is lacking. The present work evaluates the effects of neonatal HI on hippocampal ganglioside synthesis. Seven-day-old rat pups were exposed to HI for 2.5 h according to the modified Levine model and samples from hyppocampus were obtained at 30 min as well as at 1, 2 and 4 days later...
June 2001: Neurochemical Research
T L Babb, J Pereira-Leite, G W Mathern, J K Pretorius
Hyppocampal epilepsy is a recently defined syndrome occurring in 65% of all temporal lobe epilepsies as defined by: 1) electrographic (EEG) onset in the hippocampus (HC) prior to EEG seizures elsewhere, 2) post-resection hippocampal sclerosis and mossy fiber synaptic reorganizations and 3) relief of typical complex partial seizures after surgical resection of the hyppocampus. We used intrahippocampal kainic acid injections V2 in rats at different developmental ages (postnatal 7 through adult) to develop long term spontaneous HC EEG spikes, EEG seizures, and behavioral seizures...
February 1995: Italian Journal of Neurological Sciences
E I Chumasov, N I Chalisova
The results of transplantation of various parts of the central and peripheral nervous system are considered. Transplantation of nerve trunks is used clinically, and heterogenous regeneration of the nerves results in reinnervation of tissues and organs. The spinal ganglion transplantation is successfully used in experiments with both embryonic and mature differentiated neurons. Transplantation of different parts of the cortex, some subcortical structures, hyppocampus, hypothalamus, cerebellum and the spinal cord is made using immature neurons...
1980: Arkhiv Patologii
V P Belyĭ
Reactions of the neurons of the hypothalamus, septum, amygdala of the hyppocampus, and of the brain cortex of rabbits to microionophoretic application of adrenocorticotropic hormone (ACTH) of the hypophysis, noradrenaline and acetylcholine were investigated. About half of the cells in all the brain areas under study changed the frequency of their discharges during the hormone application. The septal and the hyppocampus neurons mostly responded to ACTH by the excitation reactions, whereas neurons of the medial hypothalamus--by the inhibtion reactions...
May 1980: Problemy E̊ndokrinologii
N N Kudriavtseva, A V Osadchuk
The levels of serotonin and 5-hydroxyindoleacetic acid contents were estimated in hypothalamus, hyppocampus and midbrain of inbred mice of 12 strains. The levels of serotonin and its metabolite in various parts of brain representing different links of its serotoninergic system were shown to be genetically determined. The correlation analysis revealed that there were two, relatively autonomous genetic systems controlling biosynthesis and catabolism of serotonin in brain.
September 1982: Genetika
T Manzoni, P L Parmeggiani
No abstract text is available yet for this article.
May 15, 1964: Bollettino Della Società Italiana di Biologia Sperimentale
I V Tomilina
No abstract text is available yet for this article.
May 1970: Fiziologicheskiĭ Zhurnal SSSR Imeni I. M. Sechenova
P B Kazakova, M Ia Maĭzelis, A L Zabludovskiĭ, M L Orlova
The incorporation of 3H-leucine into the neuronal proteins of the hemispherical cortex and hyppocampus was studied in rats aged 1 and 3 months which were exposed to hypoxia and ethanol in the antenatal period. The test one-month-old animals showed activation of protein synthesis in neurons and in layers III and V of the cortex and hyppocampus. At the age of 3 months the rats showed inhibited incorporation of the label into neuronal proteins of the studied structures of the brain which was more expressed in animals which had suffered intrauterine hypoxia...
1985: Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova
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