keyword
https://read.qxmd.com/read/38098133/mechanically-reinforced-and-injectable-universal-adhesive-based-on-a-pei-paa-alg-dual-network-hydrogel-designed-by-topological-entanglement-and-catechol-chemistry
#21
JOURNAL ARTICLE
Buyun Chen, Dandan Zhu, Qiang Li, Chenhao Wang, Jiahua Cui, Zhen Zheng, Xinling Wang
Universal adhesion of hydrogels to diverse materials is essential to their extensive applications. Unfortunately, tough adhesion of wet surfaces remains an urgent challenge so far, requiring robust cohesion strength for effective stress dissipation. In this work, a dual-network hydrogel polyethylenimine-poly(acrylic acid)/alginate (PEI-PAA/Alg) with excellent mechanical strength is realized via PEI-PAA complex and calcium alginate coordination for universal adhesion by the synergistic effort of topological entanglement and catechol chemistry...
December 14, 2023: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38042064/comparison-of-quantitative-11-c-pe2i-brain-pet-studies-between-an-integrated-pet-mr-and-a-stand-alone-pet-system
#22
JOURNAL ARTICLE
João M Sousa, Lieuwe Appel, Mathias Engström, Dag Nyholm, Håkan Ahlström, Mark Lubberink
PET/MR systems demanded great efforts for accurate attenuation correction (AC) but differences in technology, geometry and hardware attenuation may also affect quantitative results. Dedicated PET systems using transmission-based AC are regarded as the gold standard for quantitative brain PET. The study aim was to investigate the agreement between quantitative PET outcomes from a PET/MR scanner against a stand-alone PET system. Nine patients with Parkinsonism underwent two 80-min dynamic PET scans with the dopamine transporter ligand [11 C]PE2I...
December 1, 2023: Physica Medica: PM
https://read.qxmd.com/read/38012795/effects-of-a-single-dose-of-amisulpride-on-functional-brain-changes-during-reward-and-motivation-related-processing-using-task-based-fmri-in-healthy-subjects-and-patients-with-major-depressive-disorder-study-protocol-for-a-randomized-clinical-trial
#23
JOURNAL ARTICLE
Luisa Carstens, Margot Popp, Christian Keicher, Rita Hertrampf, David Weigner, Marvin S Meiering, Gerd Luippold, Sigurd D Süssmuth, Christian F Beckmann, Andreas Wunder, Simone Grimm
BACKGROUND: Anhedonia and other deficits in reward- and motivation-related processing in psychiatric patients, including patients with major depressive disorder (MDD), represent a high unmet medical need. Neurobiologically, these deficits in MDD patients are mainly associated with low dopamine function in a frontostriatal network. In this study, alterations in brain activation changes during reward processing and at rest in MDD patients compared with healthy subjects are explored and the effects of a single low dose of the dopamine D2 receptor antagonist amisulpride are investigated...
November 27, 2023: Trials
https://read.qxmd.com/read/37985770/mobilization-of-endocannabinoids-by-midbrain-dopamine-neurons-is-required-for-the-encoding-of-reward-prediction
#24
JOURNAL ARTICLE
Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Cheer
Brain levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) shape motivated behavior and nucleus accumbens (NAc) dopamine release. However, it is not clear whether mobilization of 2-AG specifically from midbrain dopamine neurons is necessary for dopaminergic responses to external stimuli predicting forthcoming reward. Here, we use a viral-genetic strategy to prevent the expression of the 2-AG-synthesizing enzyme diacylglycerol lipase α (DGLα) from ventral tegmental area (VTA) dopamine cells in adult mice...
November 20, 2023: Nature Communications
https://read.qxmd.com/read/37962090/hyperdopaminergia-in-rats-is-associated-with-reverse-effort-cost-dependent-performance
#25
JOURNAL ARTICLE
Artem Savchenko, Irina Belozertseva, Damiana Leo, Ilya Sukhanov
BACKGROUND: Dopamine is implicated in the effort-based control of motivational processes; however, whether tonic dopamine regulates the effort-cost impact on motivation, is still debated. AIMS: The rats lacking the dopamine transporter (DAT), which have dramatically increased levels of the synaptic dopamine, were used in the present study to elucidate the role of the synaptic dopamine in motivational processes. METHODS: To study the reward-related processes, the progressive ratio 3 (PR3) operant schedule of food reinforcement (the ratio increases by 3 after each earned reinforcer) was performed in adult male rats (DAT knockouts (DAT-KO), heterozygotes (DAT-HT) and wild-types (DAT-WT))...
November 14, 2023: Journal of Psychopharmacology
https://read.qxmd.com/read/37958728/high-yield-of-functional-dopamine-like-neurons-obtained-in-neuroforsk-2-0-medium-to-study-acute-and-chronic-rotenone-effects-on-oxidative-stress-autophagy-and-apoptosis
#26
JOURNAL ARTICLE
Diana Alejandra Quintero-Espinosa, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Several efforts to develop new protocols to differentiate in in vitro human mesenchymal stromal cells (hMSCs) into dopamine (DA) neurons have been reported. We have formulated NeuroForsk 2.0 medium containing fibroblast growth factor type beta (FGFb), brain-derived neurotrophic factor (BDNF), melatonin, purmorphamine, and forskolin. We report for the first time that menstrual stromal cells (MenSCs) cultured in NeuroForsk 2.0 medium for 7 days transdifferentiated into DA-like neurons (DALNs) expressing specific DA lineage markers tyrosine hydroxylase-positive cells (TH+) and DA transporter-positive (DAT+) cells and were responsive to DA-induced transient Ca2+ influx...
October 30, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37953388/novel-genome-wide-associations-for-effort-valuation-and-psychopathology-in-children-and-adults
#27
JOURNAL ARTICLE
Nicholas H Nguyen, T Mitchell Mazza, Jonathan L Hess, Avery B Albert, Sarah Elfstrom, Patricia Forken, Steven D Blatt, Wanda P Fremont, Stephen V Faraone, Stephen J Glatt
The Research Domain Criteria (RDoC) initiative was established by the US National Institute of Mental Health as a multilevel, disorder-agnostic framework for analysis of human psychopathology through designated domains and constructs, including the "Positive Valence Systems" domain focused on reward-related behavior. This study investigates the reward valuation subconstruct of "effort" and its association with genetic markers, functional neurobiological pathways, and polygenic risk scores for psychopathology in 1215 children aged 6-12 and their parents (n = 1044)...
November 12, 2023: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://read.qxmd.com/read/37948613/sprayable-multifunctional-black-phosphorus-hydrogel-with-on-demand-removability-for-joint-skin-wound-healing
#28
JOURNAL ARTICLE
Xiaoya Ding, Yunru Yu, Lu Fan, Wenzhao Li, Feika Bian, Jinglin Wang, Yuanjin Zhao
Wound healing remains a critical challenge in regenerative engineering. Great efforts have been devoted to develop functional patches for wound healing. Herein, we present a novel sprayable black phosphorus (BP)-based multifunctional hydrogel with on-demand removability as a joints skin wound dressing. The hydrogel is facilely prepared by mixing dopamine-modified oxidized hyaluronic acid, cyanoacetate group-functionalized dextran containing black phosphorus, and the catalyst histidine. The catechol-containing dopamine could not only enhance tissue adhesiveness, but also endow the hydrogel with antioxidant capacity...
November 10, 2023: Advanced Healthcare Materials
https://read.qxmd.com/read/37907751/relevance-of-the-anterior-cingulate-cortex-volume-and-personality-in-motivated-physical-activity-behaviors
#29
JOURNAL ARTICLE
Anna Miró-Padilla, Jesús Adrián-Ventura, Anastasia Cherednichenko, Irene Monzonís-Carda, Maria Reyes Beltran-Valls, Diego MolinerUrdiales, César Ávila
Some recent theories about the origins and maintenance of regular physical activity focus on the rewards of the properties of practicing this activity. Animal and human studies have demonstrated that mesolimbic dopamine plays a crucial role in the involvement in voluntary physical activity. Here, we test this possible role in a sample of 66 right-handed healthy young adults by studying the influence of personality and the volume of reward-related brain areas on individual differences in voluntary physical activity, objectively measured by accelerometer and subjectively self-reported by questionnaire...
October 31, 2023: Communications Biology
https://read.qxmd.com/read/37901790/reducing-the-receipt-of-contraindicated-medications-in-patients-with-parkinson-disease
#30
JOURNAL ARTICLE
Caroline Goldin, Stefan Sillau, Elisa Worledge, Jarrett Bremmer, Robbie Cummins, Kathryn Tremolet de Villers, Michelle E Fullard
BACKGROUND: The administration of antidopaminergic medications to patients with Parkinson's disease (PD) can exacerbate symptoms, and in the hospital setting, can lead to complications and increased length of stay. Despite efforts to improve medication administration through provider education and patient-centered interventions, the problem persists, with an estimated 21-43% of hospitalized PD patients receiving dopamine blocking medications. METHODS: In this study, a best practice alert (BPA) was developed that was triggered when an antidopaminergic medication was ordered in the Emergency Department or hospital for a patient with a diagnosis of PD in the EMR...
2023: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/37901180/in-drop-thermal-cycling-of-microcrystal-assembly-for-senescence-control-masc-with-minimal-variation-in-efficacy
#31
JOURNAL ARTICLE
Ryan C Miller, Jonghwi Lee, Young Jun Kim, Hee-Sun Han, Hyunjoon Kong
The secretome from mesenchymal stem cells (MSCs) has recently gained attention for new therapeutics. However, clinical application requires in vitro cell manufacturing to attain enough cells. Unfortunately, this process often drives MSCs into a senescent state that drastically changes cellular secretion activities. Antioxidants are used to reverse and prevent the propagation of senescence; however, their activity is short-lived. Polymer-stabilized crystallization of antioxidants has been shown to improve bioactivity, but the broad crystal size distribution (CSD) significantly increases the efficacy variation...
September 12, 2023: Advanced Functional Materials
https://read.qxmd.com/read/37892974/catecholamine-variations-in-pediatric-gastrointestinal-disorders-and-their-neuropsychiatric-expression
#32
JOURNAL ARTICLE
Loredana Matiș, Bogdana Ariana Alexandru, Timea Claudia Ghitea
The interplay between the central nervous system and the intestinal environment hinges on neural, hormonal, immune, and metabolic reactions. Over decades, significant effort has gone into exploring the link between the digestive system and the brain. The primary objective of this study is to assess catecholamine levels in children with neuropsychiatric disorders. We aim to examine how these levels impact the mental and physical wellbeing of these children, with a specific focus on psychoemotional symptoms and cognitive performance...
September 22, 2023: Biomedicines
https://read.qxmd.com/read/37891948/the-nadph-link-between-the-renin-angiotensin-system-and-the-antioxidant-mechanisms-in-dopaminergic-neurons
#33
REVIEW
Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteban
The renin angiotensin system (RAS) has several components including signaling peptides, enzymes, and membrane receptors. The effort in characterizing this system in the periphery has led to the approval of a class of antihypertensives. Much less is known about RAS in the central nervous system. The production of RAS peptides and the expression of several RAS enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of Parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain...
October 16, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37881541/-gpr88-deletion-impacts-motivational-control-without-overt-disruptions-to-striatal-dopamine
#34
JOURNAL ARTICLE
Daisy L Spark, Michela H Vermeulen, Rocío A de la Fuente Gonzalez, Cassandra J Hatzipantelis, Patricia Rueda, Tara Sepehrizadeh, Michael De Veer, Clotilde Mannoury la Cour, Alex Fornito, Monica Langiu, Gregory D Stewart, Jess Nithianantharajah, Christopher J Langmead
BACKGROUND: Disrupted motivational control is a common-but poorly treated-feature of psychiatric disorders, arising via aberrant mesolimbic dopaminergic signaling. GPR88 is an orphan G protein-coupled receptor that is highly expressed in the striatum and therefore well placed to modulate disrupted signaling. While the phenotype of Gpr88 knockout mice suggests a role in motivational pathways, it is unclear whether GPR88 is involved in reward valuation and/or effort-based decision making in a sex-dependent manner and whether this involves altered dopamine function...
October 2023: Biol Psychiatry Glob Open Sci
https://read.qxmd.com/read/37866012/distributed-dopaminergic-signaling-in-the-basal-ganglia-and-its-relationship-to-motor-disability-in-parkinson-s-disease
#35
REVIEW
Shenyu Zhai, Qiaoling Cui, DeNard V Simmons, D James Surmeier
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been thought that loss of dopaminergic signaling in one basal ganglia region - the striatum - was solely responsible for the network pathophysiology causing PD motor symptoms. While our understanding of dopamine (DA)'s role in modulating striatal circuitry has deepened in recent years, it also has become clear that it acts in other regions of the basal ganglia to influence movement...
October 20, 2023: Current Opinion in Neurobiology
https://read.qxmd.com/read/37827227/kinin-b1-receptor-modulates-glucose-homeostasis-and-physical-exercise-capacity-by-altering-adrenal-catecholamine-synthesis-and-secretion
#36
JOURNAL ARTICLE
Marcos Fernandes Gregnani, Alexandre Budu, Rogério Oliveira Batista, Fábio Henrique Ornellas, Gabriel Rufino Estrela, Adriano Cleis Arruda, Leandro Ceotto Freitas Lima, Jean Lucas Kremer, Lys Angela Favaroni Mendes, Dulce Elena Casarini, Claudimara Ferini Pacicco Lotfi, Lila Missae Oyama, Michael Bader, Ronaldo Carvalho Araújo
Our group has shown in several papers that kinin B1 receptor (B1R) is involved in metabolic adaptations, mediating glucose homeostasis and interfering in leptin and insulin signaling. Since catecholamines are involved with metabolism management, we sought to evaluate B1R role in catecholamine synthesis/secretion. Using B1R global knockout mice, we observed increased basal epinephrine content, accompanied by decreased hepatic glycogen content and increased glucosuria. When these mice were challenged with maximal intensity exercise, they showed decreased epinephrine and norepinephrine response, accompanied by disturbed glycemic responses to effort and poor performance...
October 10, 2023: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/37795580/sink-or-swim-does-a-worm-paralysis-phenotype-hold-clues-to-neurodegenerative-disease
#37
REVIEW
Peter Rodriguez, Randy D Blakely
Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating, particularly given the limited options for treatment. Advances in genetic technologies have allowed for efficient modeling of NDDs in animals and brought hope for new disease-modifying medications. The complexity of the mammalian brain and the costs and time needed to identify and develop therapeutic leads limits progress. Modeling NDDs in invertebrates, such as the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans, offers orders of magnitude increases in speed of genetic analysis and manipulation, and can be pursued at substantially reduced cost, providing an important, platform complement and inform research with mammalian NDD models...
October 5, 2023: Journal of Cellular Physiology
https://read.qxmd.com/read/37788571/the-neurobiology-of-activational-aspects-of-motivation-exertion-of-effort-effort-based-decision-making-and-the-role-of-dopamine
#38
REVIEW
John D Salamone, Mercè Correa
Motivational processes are complex and multifaceted, with both directional and activational aspects. Behavioral activation and exertion of effort are functions that enable organisms to overcome obstacles separating them from significant outcomes. In a complex environment, organisms make cost/benefit decisions, assessing work-related response costs and reinforcer preference. Animal studies have challenged the general idea that dopamine (DA) is best viewed as the reward transmitter and instead have illustrated the involvement of DA in activational and effort-related processes...
January 18, 2024: Annual Review of Psychology
https://read.qxmd.com/read/37753198/recent-advances-in-drug-discovery-efforts-targeting-the-sigma-1-receptor-system-implications-for-novel-medications-designed-to-reduce-excessive-drug-and-food-seeking
#39
JOURNAL ARTICLE
Liam G Knowles, Abanoub J Armanious, Youyi Peng, William J Welsh, Morgan H James
Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use disorders (SUDs), alcohol use disorder (AUD) and some eating disorders, impose a significant burden on individuals and society. Despite their high prevalence and substantial morbidity and mortality rates, treatment options for these disorders remain limited. Over the past two decades, there has been a gradual accumulation of evidence pointing to the sigma-1 receptor (S1R) system as a promising target for therapeutic interventions designed to treat these disorders...
December 2023: Addict Neurosci
https://read.qxmd.com/read/37686060/brain-dopamine-clock-interactions-regulate-cardiometabolic-physiology-mechanisms-of-the-observed-cardioprotective-effects-of-circadian-timed-bromocriptine-qr-therapy-in-type-2-diabetes-subjects
#40
REVIEW
Anthony H Cincotta
Despite enormous global efforts within clinical research and medical practice to reduce cardiovascular disease(s) (CVD), it still remains the leading cause of death worldwide. While genetic factors clearly contribute to CVD etiology, the preponderance of epidemiological data indicate that a major common denominator among diverse ethnic populations from around the world contributing to CVD is the composite of Western lifestyle cofactors, particularly Western diets (high saturated fat/simple sugar [particularly high fructose and sucrose and to a lesser extent glucose] diets), psychosocial stress, depression, and altered sleep/wake architecture...
August 26, 2023: International Journal of Molecular Sciences
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