Marcos Fernandes Gregnani, Alexandre Budu, Rogério Oliveira Batista, Fábio Henrique Ornellas, Gabriel Rufino Estrela, Adriano Cleis Arruda, Leandro Ceotto Freitas Lima, Jean Lucas Kremer, Lys Angela Favaroni Mendes, Dulce Elena Casarini, Claudimara Ferini Pacicco Lotfi, Lila Missae Oyama, Michael Bader, Ronaldo Carvalho Araújo
Our group has shown in several papers that kinin B1 receptor (B1R) is involved in metabolic adaptations, mediating glucose homeostasis and interfering in leptin and insulin signaling. Since catecholamines are involved with metabolism management, we sought to evaluate B1R role in catecholamine synthesis/secretion. Using B1R global knockout mice, we observed increased basal epinephrine content, accompanied by decreased hepatic glycogen content and increased glucosuria. When these mice were challenged with maximal intensity exercise, they showed decreased epinephrine and norepinephrine response, accompanied by disturbed glycemic responses to effort and poor performance...
October 10, 2023: Molecular and Cellular Endocrinology