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https://www.readbyqxmd.com/read/27881982/milestones-of-hematopoietic-stem-cell-transplantation-from-first-human-studies-to-current-developments
#1
REVIEW
Mateja Kralj Juric, Sakhila Ghimire, Justyna Ogonek, Eva M Weissinger, Ernst Holler, Jon J van Rood, Machteld Oudshoorn, Anne Dickinson, Hildegard T Greinix
Since the early beginnings, in the 1950s, hematopoietic stem cell transplantation (HSCT) has become an established curative treatment for an increasing number of patients with life-threatening hematological, oncological, hereditary, and immunological diseases. This has become possible due to worldwide efforts of preclinical and clinical research focusing on issues of transplant immunology, reduction of transplant-associated morbidity, and mortality and efficient malignant disease eradication. The latter has been accomplished by potent graft-versus-leukemia (GvL) effector cells contained in the stem cell graft...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27686460/esicm-lives-2016-part-two-milan-italy-1-5-october-2016
#2
S Sivakumar, F S Taccone, K A Desai, C Lazaridis, M Skarzynski, M Sekhon, W Henderson, D Griesdale, L Chapple, A Deane, L Williams, R Strickland, K Lange, D Heyland, M Chapman, M J Rowland, P Garry, J Westbrook, R Corkill, C A Antoniades, K T Pattinson, G Fatania, A J Strong, R B Myers, C Lazaridis, C M Jermaine, C S Robertson, C G Rusin, J Hofmeijer, L Sondag, M C Tjepkema-Cloostermans, A Beishuizen, F H Bosch, M J A M van Putten, L Carteron, C Patet, D Solari, M Oddo, M A Ali, C Dias, R Almeida, A Vaz-Ferreira, J Silva, E Monteiro, A Cerejo, A P Rocha, A A Elsayed, A M Abougabal, B N Beshey, K M Alzahaby, S Pozzebon, A Blandino Ortiz, S Cristallini, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, M Hravnak, K Yousef, Y Chang, E Crago, R M Friedlander, S A Abdelmonem, S A Tahon, T A Helmy, H S Meligy, F Puig, I Dunn-Siegrist, J Pugin, S Gupta, D Govil, S Srinivasan, S J Patel, J K N, A Gupta, D S Tomar, M Shafi, R Harne, D P Arora, N Talwar, S Mazumdar, E E Papakrivou, D 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No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27686459/esicm-lives-2016-part-three-milan-italy-1-5-october-2016
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K Oguzhan, O Demirkiran, M Kirman, S Bozbay, M E Kosuk, G Asyralyyeva, M Dilek, M Duzgun, S Telli, M Aydin, F Yilmazer, L E Hodgson, B D Dimitrov, C Stubbs, L G Forni, R Venn, D Vedage, S Shawaf, P Naran, N Sirisena, J Kinnear, B D Dimitrov, L E Hodgson, C Stubbs, L G Forni, R Venn, J Gonzalez Londoño, C Lorencio Cardenas, A Sánchez Ginés, C Murcia Gubianas, E Clapes Sánchez, J M Sirvent, V Panafidina, I Shlyk, V Ilyina, S Judickas, G Kezyte, I Urbanaviciute, M Serpytis, E Gaizauskas, J Sipylaite, C L Sprung, G Munteanu, R C Morales, H Kasdan, T Volker, A Reiter, Y Cohen, Y Himmel, J Meissonnier, M E Banderas-Bravo, C Gómez-Jiménez, M V García-Martínez, J F Martínez-Carmona, J F Fernández-Ortega, M J O'Dwyer, M Starczewska, M Wilks, J L Vincent, M Torsvik, L T Gustad, I L Bangstad, L J Vinje, J K Damås, E Solligård, A Mehl, M Tsunoda, M Kang, M Saito, N Saito, N Akizuki, M Namiki, M Takeda, J Yuzawa, A Yaguchi, F Frantzeskaki, P Tsirigotis, S Chondropoulos, E Paramythiotou, M Theodorakopoulou, M Stamouli, K Gkirkas, I K Dimopoulou, S Makiko, M Tsunoda, M Kang, J Yuzawa, N Akiduki, M Namiki, M Takeda, A Yaguchi, S Preau, M Ambler, A Sigurta, S Saeed, M Singer, S Jochmans, J Chelly, L V P Vong, O Sy, J Serbource-Goguel, N Rolin, C M Weyer, R I Abdallah, C Adrie, C Vinsonneau, M Monchi, U Mayr, W Huber, E Karsten, T Lahmer, P Thies, B Henschel, G Fischer, R M Schmid, O Ediboglu, S Ataman, I Naz, G Yaman, C Kirakli, P L Su, P S Kou, W C Lin, C W Chen, J A Benítez Lozano, P Carmona Sánchez, J E Barrueco Francioni, F Ruiz Ferrón, J M Serrano Simón, Z Riad, M Mezidi, M Aublanc, S Perinel, F Lissonde, A Louf-Durier, H Yonis, R Tapponnier, J C Richard, B Louis, C Guérin, M Mezidi, H Yonis, M Aublanc, F Lissonde, A Louf-Durier, S Perinel, R Tapponnier, J C Richard, C Guérin, K Marmanidou, M Oikonomou, C Nouris, C Loizou, E Soilemezi, D Matamis, P Somhorst, D Gommers, K Hayashi, T Hirayama, T Yumoto, K Tsukahara, A Iida, N Nosaka, K Sato, T Ugawa, A Nakao, Y Ujike, S Hirohata, F Mojoli, F Torriglia, M Giannantonio, A Orlando, S Bianzina, G Tavazzi, S Mongodi, M Pozzi, G A Iotti, A Braschi, D Jansen, S Gadgil, J Doorduin, L Roesthuis, J G van der Hoeven, L M A Heunks, G Q Chen, X M Sun, X He, Y L Yang, Z H Shi, M Xu, J X Zhou, S M Pereira, M R Tucci, B F F Tonelotto, C M Simoes, C C A Morais, M S Pompeo, F U Kay, M B P Amato, J E Vieira, S Suzuki, Y Mihara, Y Hikasa, S Okahara, H Morimatsu, H M Kwon, Y J Moon, S H Lee, K W Jung, W J Shin, I G Jun, J G Song, G S Hwang, S Lee, Y J Moon, H M Kwon, K Jung, W J Shin, I G Jun, J G Song, G S Hwang, A Ramelli, T Manca, F Corradi, C Brusasco, F Nicolini, T Gherli, R Brianti, P Fanzaghi, A Vezzani, B A Tudor, D A Klaus, D Lebherz-Eichinger, C Lechner, C Schwarz, M Bodingbauer, R Seemann, K Kaczirek, E Fleischmann, G A Roth, C G Krenn, A Malyshev, S Sergey, Y Yamaguchi, T Nomura, E Yoshitake, M Idei, T Yoshida, S Takaki, O Yamaguchi, M Kaneko, T Goto, N Tencé, I Zaien, M Wolf, P Trouiller, F M Jacobs, J M Kelly, P Veigas, S Hollands, A Min, S Rizoli, C M Coronado Robles, M A Montes de Oca Sandoval, O Tarabrin, D Gavrychenko, G Mazurenko, P Tarabrin, I Palacios Garcia, A Diaz Martin, M Casado Mendez, V Arellano Orden, R Leal Noval, C McCue, L Gemmell, A MacKay, J Luján, P Villa, B Llorente, R Molina, L Alcázar, C Arenillas Juanas, S Rogero, T Pascual, J A Cambronero, P Matía Almudévar, J Palamidessi Domínguez, S Alcántara Carmona, D Palacios Castañeda, A Naharro Abellán, A Pérez Lucendo, L Pérez Pérez, R Fernández Rivas, N Martínez Sanz, J Veganzones Ramos, P Rodríguez Villamizar, S Javadpour, N Kalani, T Amininejad, S Jamali, S Sobhanian, A Laurent, M Bonnet, R Rigal, P Aslanian, P Hebert, G Capellier, M R Diaz Contreras, C Rodriguez Mejías, F C Santiago Ruiz, M Duro Lombardo, J Castaño Perez, E Aguayo de Hoyos, A Estella, R Viciana, L Perez Fontaiña, T Rico, V Perez Madueño, M Recuerda, L Fernández, A Sandiumenge, S Bonet, C Mazo, M Rubiera, J C Ruiz-Rodríguez, R M Gracia, E Espinel, T Pont, A Kotsopoulos, N Jansen, W F Abdo, A Gopcevic, Z Gavranovic, M Vucic, M Zlatic Glogoski, L Videc Penavic, A Horvat, L Martin-Villen, J J Egea-Guerero, J Revuelto-Rey, T Aldabo-Pallas, E Correa-Chamorro, A I Gallego-Corpa, P Ruiz Del Portal-Ruiz Granados, V Faivre, L Wildenberg, B Huot, A C Lukaszewicz, M Simsir, C Mengelle, D Payen, N Martinez Sanz, B Lobo Valbuena, M Valdivia de la Fuente, P Matía Almudena, L Pérez Pérez, S Alcántara Carmona, A Navarro Abellán, I Fernández Simón, J J Rubio Muñoz, J Veganzones Ramos, S Alcantara Carmona, P Matia Almudevar, A Naharro Abellan, M A Perez Lucendo, L Perez Perez, J Palamidessi Dominguez, R Fernandez Rivas, P Rodriguez Villamizar, S Wee, C Ong, Y H Lau, Y Wong, M E Banderas-Bravo, V Olea-Jiménez, J M Mora-Ordóñez, C Gómez-Jiménez, J L Muñoz-Muñoz, J Vallejo-Báez, D Daga-Ruiz, M Lebrón-Gallardo, G Rialp, J M Raurich, I Morán, M C Martín, G Heras, A Mas, I Vallverdú, S Hraiech, J Bourenne, C Guervilly, J M Forel, M Adda, P Sylla, A Mouaci, M Gainnier, L Papazian, P R Bauer, A Kumbamu, M E Wilson, J K Pannu, J S Egginton, R Kashyap, O Gajic, S Yoshihiro, M Sakuraya, M Hayakawa, A Hirata, N Kawamura, T Tsutui, K Yoshida, Y Hashimoto, C H Chang, H C Hu, L C Chiu, C Y Hung, S H Li, K C Kao, S Sibley, J Drover, C D'Arsigny, C Parker, D Howes, S Moffatt, J Erb, R Ilan, D Messenger, I Ball, J G Boyd, M Harrison, S Ridi, J Muscedere, A H Andrade, R C Costa, V A Souza, V Gonzalez, V Amorim, F Rolla, C A C Abreu Filho, R Miranda, S Atchasiri, P Buranavanich, T Wathanawatthu, S Suwanpasu, C Bureau, C Rolland-Debord, T Poitou, M Clavel, S Perbet, N Terzi, A Kouatchet, T Similowski, A Demoule, P Diaz, J Nunes, S Escórcio, G Silva, S Chaves, M Jardim, M Câmara, N Fernandes, R Duarte, J J Jardim, C A Pereira, J J Nóbrega, C M Chen, C C Lai, K C Cheng, W Chou, S J Lee, Y S Cha, W Y Lee, M Onodera, E Nakataki, J Oto, H Imanaka, M Nishimura, A Khadjibaev, D Sabirov, A Rosstalnaya, R Akalaev, F Parpibaev, E Antonucci, P Rossini, S Gandolfi, E Montini, S Orlando, M van Nes, F Karachi, S Hanekom, A H Andrade, U V Pereira, C A C Abreu Filho, R C Costa, M S W Parkin, M Moore, A H Andrade, R C Costa, K V Silva Carvalho, C A C Abreu Filho, H J Min, H J Kim, D S Lee, Y Y Choi, E Y Lee, I Song, D J Kim, Y Y E, J W Kim, J S Park, Y J Cho, J H Lee, J W Suh, Y H Jo, K S Kim, Y J Lee, J Ferrero-Calleja, D Merino-Vega, A I González-Jiménez, M Sigcha Sigcha, A Hernández-Tejedor, A Martin-Vivas, Á Gabán-Díez, R Ruiz-de Luna, N De la Calle-Pedrosa, I Temprano-Gómez, D Afonso-Rivero, J I Pellin-Ariño, A Algora-Weber, R R L Fumis, A B Ferraz, J M Vieira Junior, H Kirca, O Cakin, M Unal, H Mutlu, A Ramazanoglu, M Cengiz, E A Nicolini, F G F Pelisson, R S Nunes, S L da Silva, M M Carreira, F Bellissimo-Rodrigues, M A Ferez, A Basile-Filho, H C Chao, C M Chen, L Chen, M Hravnak, G Clermont, M Pinsky, A Dubrawski, J Luján Varas, R Molina Montero, L Alcázar Sánchez-Elvira, P Villa Díaz, C Pintado Delgado, B Llorente Ruiz, A Pardo Guerrero, J A Cambronero Galache, H Sherif, H Hassanin, R El Hossainy, W Samy, H Ly, H David, P Burtin, C Charpentier, M Barral, P Courant, E Fournel, L Gaide-Chevronnay, M Durand, P Albaladejo, J F Payen, O Chavanon, A Blandino Ortiz, S Pozzebon, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, F Fumagalli, S Scala, R Affatato, M De Maglie, D Zani, D Novelli, C Marra, A Luciani, D De Zani, M Luini, T Letizia, D Pravettoni, L Staszewsky, S Masson, A Belloli, M Di Giancamillo, E Scanziani, R Latini, G Ristagno, Y C Kye, G J Suh, W Y Kwon, K S Kim, K M Yu, G Babini, G Ristagno, L Grassi, F Fumagalli, S Bendel, M De Maglie, R Affatato, S Masson, R Latini, E Scanziani, M Reinikainen, M Skrifvars, F Kappler, M Blobner, S J Schaller, A Roasio, E Costanzo, S Cardellino, E Iesu, F Zama Cavicchi, V Fontana, L Nobile, J L Vincent, J Creteur, F S Taccone, M Park, K M You, G J Suh, W Y Kwon, S B Ko, K S Kim, A Xini, L Marca, O Lheureux, A Brasseur, J L Vincent, J Creteur, F S Taccone, A Beane, M C K T Thilakasiri, A P De Silva, T Stephens, C S Sigera, P Athapattu, S Jayasinghe, A Padeniya, R Haniffa, A Iglesias Santiago, V Chica Sáez, R de la Chica Ruiz-Ruano, A Sánchez González, N Kunze-Szikszay, S Wand, P Klapsing, A Wetz, T Heyne, K Schwerdtfeger, M Troeltzsch, M Bauer, M Quintel, O Moerer, D J Cook, W B Rutherford, D C Scales, N K Adhikari, B H Cuthbertson, T Suzuki, T Takei, K Fushimi, M Iwamoto, S Nakagawa, N Mendsaikhan, T Begzjav, G Lundeg, M W Dünser, D González Romero, J L Santana Cabrera, J D Martín Santana, Y Santana Padilla, H Rodríguez Pérez, R Lorenzo Torrent, R Kleinpell, I Chouris, V Radu, M Stougianni, A Lavrentieva, D Lagonidis, R D T Price, A Day, N Arora, M A Henderson, S Hickey, M I Almeida Costa, J P Carvalho, A A Gomes, P J Mergulhão, K K C Chan, H P Shum, W W Yan, B Maghsoudi, S H Tabei, M Masjedi, G Sabetian, H R Tabatabaei, A Akbarzadeh, S Saigal, A Pakhare, R Joshi, S K Pattnaik, B Ray, A F Rousseau, L Michel, M Bawin, E Cavalier, J Y Reginster, P Damas, O Bruyere, J C Zhou, H Cauwenberghs, A De Backer, H Neels, I Deblier, J Berghmans, D Himpe, J A Barea-Mendoza, I Prieto Portillo, M Valiente Fernández, R Garcia Gigorro, J L Perez Vela, H Marín Mateos, S Chacón Alves, G Morales Varas, A Rodriguez-Biendicho, E Renes Carreño, J C Montejo González, J S Yang, C H Chiang, W T Hung, W C Huang, C C Cheng, K C Lin, S C Lin, K R Chiou, S R Wann, K L Lin, P L Kang, G Y Mar, C P Liu, J C Zhou, Y J Choi, S Z Yoon, A Gordillo-Brenes, M D Fernandez-Zamora, L Perez-Borrero, M D Arias-Verdu, E Aguilar-Alonso, A Herruzo-Aviles, M Garcia-Delgado, R Hinojosa-Perez, E Curiel-Balsera, R Rivera-Fernandez, S P Gómez Lesmes, L E De la Cruz Rosario, A Ansotegui Hernández, A N García Herrera, E Regidor Sanz, M J Gómez Sánchez, J Barado Hualde, O Agudo Pascual, J P Tirapu León, J M Guergue Irazabal, A González Pérez, P Alvarez Fernández, L Lopéz Amor, G Muñiz Albaiceta, S P Gómez Lesmes, L E De la Cruz Rosario, A Ansotegui Hernández, E Regidor Sanz, M J Gómez Sánchez, S Aldunate Calvo, A N García Herrera, J Barado Hualde, O Agudo Pascual, J P Tirapu León, A Corona, C Ruffini, A Spazzadeschi, F Marrazzo, A Gandola, R Sciurti, C Savi, E Catena, M W Ke, C C Cheng, W C Huang, C H Chiang, W T Hung, K C Lin, S C Lin, S R Wann, K R Chiou, C J Tseng, P L Kang, G Y Mar, C P Liu, P Bertini, F De Sanctis, F Guarracino, P Bertini, R Baldassarri, F Guarracino, S H Buitinck, P H J van der Voort, J Oto, E Nakataki, Y Tsunano, M Izawa, N Tane, M Onodera, M Nishimura, S Ghosh, A Gupta, A De Gasperi, E Mazza, R Limuti, M Prosperi, N Bissenova, A Yergaliyeva, L Talan, G Yılmaz, G Güven, F Yoruk, N D Altıntas, D N Mukherjee, L K Agarwal, K Mandal, M Palomar, B Balsera, M Vallverdu, M Martinez, M Garcia, D Castellana, R Lopez, F Barcenilla, G E Kaminsky, R Carreño, A Escribá, M Fuentes, V Gálvez, R Del Olmo, B Nieto, C Vaquerizo, J Alvarez, M A De la Torre, E Torres, E Bogossian, S Aranha Nouer, D Ribeiro Salgado, S Carvalho Brugger, G Jiménez Jiménez, M Miralbés Torner, M Vallverdú Vidal, B Balsera Garrido, X Nuvials Casals, F Barcenilla Gaite, J Trujillano Cabello, M Palomar Martínez, M Doganci, S Izdes, S Guzeldag Besevli, A Alkan, B Kayaaslan, C Sánchez Ramírez, L Caipe Balcázar, M Cabrera Santana, M A Hernández Viera, S Hípola Escalada, C F Lübbe Vázquez, S M Marrero Penichet, F Artiles Campelo, M A De La Cal López, P Saavedra Santana, S Ruíz Santana, X Repessé, M Artiguenave, S Paktoris-Papine, F Espinasse, A Dinh, F El Sayed, C Charron, G Géri, A Vieillard-Baron, K Marmanidou, M Oikonomou, C Nouris, K Dimitroulakis, E Soilemezi, D Matamis, A Ferré, M Guillot, J L Teboul, D Lichtenstein, G Mézière, C Richard, X Monnet, T Pham, G Beduneau, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, S Prīdāne, O Sabeļņikovs, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, G Beduneau, T Pham, F Schortgen, L Piquilloud, E Zogheib, M Jonas, F Grelon, I Runge, N Terzi, S Grangé, G Barberet, P G Guitard, J P Frat, A Constan, J M Chrétien, J Mancebo, A Mercat, J C M Richard, L Brochard, E Kondili, C Psarologakis, S Kokkini, V Amargianitakis, D Babalis, A Chytas, I Chouvarda, K Vaporidi, D Georgopoulos, O Trapp, A Kalenka, F Mojoli, A Orlando, I Bianchi, F Torriglia, S Bianzina, M Pozzi, G A Iotti, A Braschi, J A Benítez Lozano, P Carmona Sánchez, J E Barrueco Francioni, F Ruiz Ferrón, J M Serrano Simón, S Spadaro, D S Karbing, A Gioia, F Moro, F Dalla Corte, T Mauri, C A Volta, S E Rees, M V Petrova, R Mohan, A V Butrov, S D Beeharry, M V Vatsik, F I Sakieva, F Gobert, H Yonis, R Tapponnier, R Fernandez, M A Labaune, J F Burle, J Barbier, B Vincent, M Cleyet, J C Richard, C Guérin, C Righy Shinotsuka, J Creteur, F S Taccone, S Törnblom, S Nisula, S Vaara, M Poukkanen, S Andersson, V Pettilä, E Pesonen, Z Xie, X Liao, Y Kang, J Zhang, K Kubota, M Egi, S Mizobuchi, S Hegazy, A El-Keraie, E El Sayed, M Abd El Hamid, N J Rodrigues, M Pereira, I Godinho, J Gameiro, M Neves, J Gouveia, Z Costa E Silva, J A Lopes, J Mckinlay, M Kostalas, G Kooner, G Dudas, A Horton, C Kerr, N Karanjia, B Creagh-Brown, L Forni, A Yamazaki, M Sanz Ganuza, J A Martinez Molina, F Hidalgo Martinez, M T Chiquito Freile, N Garcia Fernandez, P Medrano Travieso, A Bandert, R Frithiof, M Lipcsey, D Smekal, P Schlaepfer, J D Durovray, V Plouhinec, C Chiappa, R Bellomo, A G Schneider, S Mitchell, J Durrant, H Street, E Dunthorne, J Shears, C Hernandez Caballero, R Hutchison, S Schwarze, S Ghabina, E Thompson, J R Prowle, C J Kirwan, C A Gonzalez, J L Pinto, V Orozco, J A Patiño, P K Garcia, K M Contreras, P Rodriguez, J E Echeverri
No abstract text is available yet for this article.
September 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27506482/enemas-suppositories-and-rectal-stimulation-are-not-effective-in-accelerating-enteral-feeding-or-meconium-evacuation-in-low-birthweight-infants-a-systematic-review
#4
Kim Kamphorst, Ydelette Sietsma, Annemieke J Brouwer, Paul J T Rood, Agnes van den Hoogen
: Early full enteral feeding in preterm infants decreases morbidity and mortality. Our systematic review covered the effectiveness of rectal stimulation, suppositories and enemas on stooling patterns and feeding tolerance in low-birthweight infants born at up to 32 weeks. It comprised seven studies published between 2007 and 2014 and covered 495 infants. CONCLUSION: Suppositories were ineffective in shortening the time to reach full enteral feeding, and the evidence on enemas was contradictory...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27469903/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-t790m-mutant-egfr-inhibitor-osimertinib-azd9291-in-human-plasma
#5
Johannes J M Rood, Mark T J van Bussel, Jan H M Schellens, Jos H Beijnen, Rolf W Sparidans
A method for the quantitative analysis by ultra-performance liquid chromatography-tandem mass spectrometry of the highly selective irreversible covalent inhibitor of EGFR-TK, osimertinib in human plasma was developed and validated, using pazopanib as an internal standard. The validation was performed in a range from 1 to 1000ng/ml, with the lowest level corresponding to the lower limit of quantitation. Gradient elution was performed on a 1.8μm particle trifunctional bonded C18 column by 1% (v/v) formic acid in water, and acetonitrile as mobile phase...
September 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27416936/knowledge-about-systemic-inflammatory-response-syndrome-and-sepsis-a-survey-among-dutch-emergency-department-nurses
#6
L C van den Hengel, T Visseren, P E Meima-Cramer, P P M Rood, S C E Schuit
BACKGROUND: Sepsis has a high mortality. Early recognition and timely treatment are essential for patient survival. The aim of this study is to examine the factors that influence the knowledge and recognition of systemic inflammatory response syndrome (SIRS) criteria and sepsis by emergency department (ED) nurses. METHODS: A prospective, multi-center study including 216 ED nurses from 11 hospitals and academic medical centers in The Netherlands was conducted in 2013...
December 2016: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27387846/pediatric-seizure-related-posttraumatic-stress-and-anxiety-symptoms-treated-with-emdr-a-case-series
#7
Elmedina Dautovic, Carlijn de Roos, Yanda van Rood, Agnes Dommerholt, Roos Rodenburg
PURPOSE: To examine the potential effects of eye movement desensitization and reprocessing (EMDR) in children with epilepsy-related posttraumatic stress and/or anxiety symptoms, using a case series design. METHODS: Five children (aged 8-18) with epilepsy identified for seizure-related posttraumatic stress and/or anxiety symptoms were treated with EMDR. To examine potential treatment effects, posttraumatic stress and anxiety symptoms were assessed (CRTI and SCARED) pre- and post-EMDR and at 3-month follow-up...
2016: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/27290305/sufficient-sleep-quality-easily-measured-a-multicenter-centre-study-in-dutch-icus
#8
P Rood, P Pickkers, J G van der Hoeven, M van den Boogaard
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27290293/development-of-a-multicomponent-intervention-program-to-prevent-delirium-in-intensive-care-unit-patients
#9
A Wassenaar, M van den Boogaard, P Rood, L Schoonhoven, P Pickkers
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27130585/procalcitonin-guided-therapy-for-the-initiation-of-antibiotics-in-the-ed-a-systematic-review
#10
REVIEW
Yuri van der Does, Pleunie P M Rood, Juanita A Haagsma, Peter Patka, Eric C M van Gorp, Maarten Limper
BACKGROUND: Procalcitonin (PCT) is a new biomarker with a higher accuracy in the diagnosis of bacterial infections. Utilization of PCT may reduce the number of unnecessary antibiotics prescribed to patients and consequently may decrease the rise in antibiotic resistance. The aim of this systematic review is to determine if a PCT-guided algorithm can safely reduce the number of antibiotics prescribed to all patients with a suspected of infection in the emergency department (ED). METHODS: MEDLINE, EMBASE, Web of Science, COCHRANE central, PubMed publisher, and Google scholar were searched...
July 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27055820/supporting-successful-implementation-of-public-health-interventions-protocol-for-a-realist-synthesis
#11
Marjorie MacDonald, Bernadette Pauly, Geoff Wong, Kara Schick-Makaroff, Thea van Roode, Heather Wilson Strosher, Anita Kothari, Ruta Valaitis, Heather Manson, Warren O'Briain, Simon Carroll, Victoria Lee, Samantha Tong, Karen Dickenson Smith, Megan Ward
BACKGROUND: There is a growing emphasis in public health on the importance of evidence-based interventions to improve population health and reduce health inequities. Equally important is the need for knowledge about how to implement these interventions successfully. Yet, a gap remains between the development of evidence-based public health interventions and their successful implementation. Conventional systematic reviews have been conducted on effective implementation in health care, but few in public health, so their relevance to public health is unclear...
2016: Systematic Reviews
https://www.readbyqxmd.com/read/27048405/higher-diagnostic-accuracy-and-cost-effectiveness-using-procalcitonin-in-the-treatment-of-emergency-medicine-patients-with-fever-the-hitemp-study-a-multicenter-randomized-study
#12
RANDOMIZED CONTROLLED TRIAL
Yuri van der Does, Maarten Limper, Stephanie C E Schuit, Marten J Poley, Joost van Rosmalen, Christian Ramakers, Peter Patka, Eric C M van Gorp, Pleunie P M Rood
BACKGROUND: Fever is a common symptom in the emergency department(ED). Fever can be caused by bacterial infections, which are treated with antibiotics. Often, bacterial infections cannot be ruled out in the ED using standard diagnostics, and empiric antibiotic treatment is started. Procalcitonin(PCT) is a biomarker for bacterial infections, but its role in an undifferentiated ED population remains unclear. We hypothesize that PCT-guided therapy may reduce antibiotics prescription in undifferentiated febrile ED patients...
April 6, 2016: BMC Emergency Medicine
https://www.readbyqxmd.com/read/26900808/jon-van-rood-frcp-senior-consultant-europdonor-foundation
#13
Jon van Rood
No abstract text is available yet for this article.
March 2016: Transplantation
https://www.readbyqxmd.com/read/26896029/characteristics-of-suicidal-outpatients-with-mood-anxiety-and-somatoform-disorders-the-role-of-childhood-abuse-and-neglect
#14
Ingrid Ve Carlier, Jacqueline Gfm Hovens, Marion F Streevelaar, Yanda R van Rood, Tineke van Veen
BACKGROUND: The most prevalent psychiatric disorders are mood, anxiety and somatoform (MAS) disorders which show high mutual comorbidity, childhood trauma and elevated risk of suicidality. So far, no studies have compared suicide risk in a secondary care population with comorbid MAS disorders. This gap was taken as starting point for the study. AIMS: In comparing suicidal and non-suicidal MAS patients, the following was examined: suicide risk in the three disorder groups, socio-demographic and clinical characteristics, occurrence of childhood trauma types and contribution of childhood trauma to suicidality...
June 2016: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/26826475/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-tyrosine-kinase-inhibitor-afatinib-in-mouse-plasma-using-salting-out-liquid-liquid-extraction
#15
Rolf W Sparidans, Stephanie van Hoppe, Johannes J M Rood, Alfred H Schinkel, Jan H M Schellens, Jos H Beijnen
A quantitative bioanalytical liquid chromatography-tandem mass spectrometric (LC-MS/MS) assay for afatinib, an irreversible inhibitor of the ErbB (erythroblastic leukemia viral oncogene homolog) tyrosine kinase family, was developed and validated. Plasma samples were pre-treated using salting-out assisted liquid-liquid extraction (SALLE) with acetonitrile, magnesium chloride and a stable isotopically labeled internal standard. After dilution, the extract was directly injected into the reversed-phase liquid chromatographic system...
February 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26687803/one-million-haemopoietic-stem-cell-transplants-a-retrospective-observational-study
#16
Alois Gratwohl, Marcelo C Pasquini, Mahmoud Aljurf, Yoshiko Atsuta, Helen Baldomero, Lydia Foeken, Michael Gratwohl, Luis Fernando Bouzas, Dennis Confer, Karl Frauendorfer, Eliane Gluckman, Hildegard Greinix, Mary Horowitz, Minako Iida, Jeff Lipton, Alejandro Madrigal, Mohamad Mohty, Luc Noel, Nicolas Novitzky, José Nunez, Machteld Oudshoorn, Jakob Passweg, Jon van Rood, Jeff Szer, Karl Blume, Frederic R Appelbaum, Yoshihisa Kodera, Dietger Niederwieser
BACKGROUND: The transplantation of cells, tissues, and organs has been recognised by WHO as an important medical task for its member states; however, information about how to best organise transplantation is scarce. We aimed to document the activity worldwide from the beginning of transplantation and search for region adapted indications and associations between transplant rates and macroeconomics. METHODS: Between Jan 1, 2006, and Dec 31, 2014, the Worldwide Network for Blood and Marrow Transplantation collected data for the evolution of haemopoietic stem-cell transplantation (HSCT) activity and volunteer donors in the 194 WHO member states...
March 2015: Lancet Haematology
https://www.readbyqxmd.com/read/26540627/liquid-chromatography-tandem-mass-spectrometric-assay-for-the-simultaneous-determination-of-the-irreversible-btk-inhibitor-ibrutinib-and-its-dihydrodiol-metabolite-in-plasma-and-its-application-in-mouse-pharmacokinetic-studies
#17
Johannes J M Rood, Stephanie van Hoppe, Alfred H Schinkel, Jan H M Schellens, Jos H Beijnen, Rolf W Sparidans
A validated simple, fast and sensitive bio-analytical assay for ibrutinib and its dihydrodiol metabolite in human and mouse plasma was set up. Sample preparation was performed by protein precipitation, and addition of the respective deuterated internal standards, followed by LC-MS/MS analysis. Separation was performed on a 3.5 μm particle-size, bridged ethylene hybrid column with gradient elution by 0.1% v/v formic acid and acetonitrile. The full eluate was transferred to an electrospray interface in positive ionization mode, and subsequently analyzed by a triple quadrupole mass spectrometer by selected reaction monitoring...
January 25, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/26483497/development-of-a-diverse-human-t-cell-repertoire-despite-stringent-restriction-of-hematopoietic-clonality-in-the-thymus
#18
Martijn H Brugman, Anna-Sophia Wiekmeijer, Marja van Eggermond, Ingrid Wolvers-Tettero, Anton W Langerak, Edwin F E de Haas, Leonid V Bystrykh, Jon J van Rood, Gerald de Haan, Willem E Fibbe, Frank J T Staal
The fate and numbers of hematopoietic stem cells (HSC) and their progeny that seed the thymus constitute a fundamental question with important clinical implications. HSC transplantation is often complicated by limited T-cell reconstitution, especially when HSC from umbilical cord blood are used. Attempts to improve immune reconstitution have until now been unsuccessful, underscoring the need for better insight into thymic reconstitution. Here we made use of the NOD-SCID-IL-2Rγ(-/-) xenograft model and lentiviral cellular barcoding of human HSCs to study T-cell development in the thymus at a clonal level...
November 3, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26457642/do-reports-of-age-and-circumstances-of-first-intercourse-differ-in-a-birth-cohort-when-asked-seventeen-years-apart
#19
Nigel P Dickson, Antoinette Righarts, Thea van Roode, Claire Cameron, Jennie Connor
Conclusions about temporal changes in age and circumstances of first intercourse are generally derived from retrospective reports by people of various ages in cross-sectional studies, with an inherent assumption of no bias stemming from time since the event. We examined this assumption through repeated questions on age and circumstances of first heterosexual intercourse (FHI) at ages 21 and 38 in a birth cohort. Despite considerable movement in individual reports, there was no bias in reported age of FHI. However, a greater proportion of both men and women stated at the later assessment both partners had been equally willing (versus persuading or persuaded)...
2016: Journal of Sex Research
https://www.readbyqxmd.com/read/26304790/increased-expression-of-lysosome-membrane-protein-2-in-glomeruli-of-patients-with-idiopathic-membranous-nephropathy
#20
Ilse M Rood, Michael L Merchant, Daniel W Wilkey, Terry Zhang, Vlad Zabrouskov, Johan van der Vlag, Henry B Dijkman, Brigith K Willemsen, Jack F Wetzels, Jon B Klein, Jeroen K Deegens
Urinary microvesicles constitute a rich source of membrane-bound and intracellular proteins that may provide important clues of pathophysiological mechanisms in renal disease. In the current study, we analyzed and compared the proteome of urinary microvesicles from patients with idiopathic membranous nephropathy (iMN), idiopathic focal segmental glomerulosclerosis (iFSGS), and normal controls using an approach that combined both proteomics and pathology analysis. Lysosome membrane protein-2 (LIMP-2) was increased greater than twofold in urinary microvesicles obtained from patients with iMN compared to microvesicles of patients with iFSGS and normal controls...
November 2015: Proteomics
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