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https://www.readbyqxmd.com/read/29778873/bioanalysis-of-ibrutinib-and-its-dihydrodiol-and-glutathione-cycle-metabolites-by-liquid-chromatography-tandem-mass-spectrometry
#1
J J M Rood, P J A Dormans, M J van Haren, J H M Schellens, J H Beijnen, R W Sparidans
Ibrutinib is a targeted covalent inhibitor frequently used for the treatment of various lymphomas. In addition to oxidative metabolism, it is metabolized through glutathione coupling. The quantitative insight into this kind of metabolism is scarce, and tools for quantitation are lacking. The non-oxidative metabolism could prove a more prominent role when oxidative metabolism is impaired. Also, in-vitro studies could over-estimate the effect of CYP450-inhibition. To gain quantitative insight into this relatively unknown biotransformation pathway of the drug we have developed a validated simple, fast and sensitive bio-analytical assay for ibrutinib, dihydrodiol-ibrutinib, and the glutathione, cysteinylglycine and cysteine conjugates of ibrutinib in human plasma...
May 11, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29718947/how-ownership-rights-over-microorganisms-affect-infectious-disease-control-and-innovation-a-root-cause-analysis-of-barriers-to-data-sharing-as-experienced-by-key-stakeholders
#2
Carolina Dos S Ribeiro, Martine Y van Roode, George B Haringhuizen, Marion P Koopmans, Eric Claassen, Linda H M van de Burgwal
BACKGROUND: Genetic information of pathogens is an essential input for infectious disease control, public health and for research. Efficiency in preventing and responding to global outbreaks relies on timely access to such information. Still, ownership barriers stand in the way of timely sharing of genetic data from pathogens, frustrating efficient public health responses and ultimately the potential use of such resources in innovations. Under a One Health approach, stakeholders, their interests and ownership issues are manifold and need to be investigated...
2018: PloS One
https://www.readbyqxmd.com/read/29716912/effect-of-dynamic-light-application-on-cognitive-performance-and-well-being-of-intensive-care-nurses
#3
EDITORIAL
Koen S Simons, Enzio R K Boeijen, Marlies C Mertens, Paul Rood, Cornelis P C de Jager, Mark van den Boogaard
BACKGROUND: Exposure to bright light has alerting effects. In nurses, alertness may be decreased because of shift work and high work pressure, potentially reducing work performance and increasing the risk for medical errors. OBJECTIVES: To determine whether high-intensity dynamic light improves cognitive performance, self-reported depressive signs and symptoms, fatigue, alertness, and well-being in intensive care unit nurses. METHODS: In a single-center crossover study in an intensive care unit of a teaching hospital in the Netherlands, 10 registered nurses were randomly divided into 2 groups...
May 2018: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29688855/critical-considerations-for-the-practical-utility-of-health-equity-tools-a-concept-mapping-study
#4
Bernadette Pauly, Wanda Martin, Kathleen Perkin, Thea van Roode, Albert Kwan, Tobie Patterson, Samantha Tong, Cheryl Prescott, Bruce Wallace, Trevor Hancock, Marjorie MacDonald
BACKGROUND: Promoting health equity within health systems is a priority and challenge worldwide. Health equity tools have been identified as one strategy for integrating health equity considerations into health systems. Although there has been a proliferation of health equity tools, there has been limited attention to evaluating these tools for their practicality and thus their likelihood for uptake. METHODS: Within the context of a large program of research, the Equity Lens in Public Health (ELPH), we conducted a concept mapping study to identify key elements and themes related to public health leaders and practitioners' views about what makes a health equity tool practical and useful...
April 23, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29573030/treatment-course-and-its-predictors-in-patients-with-somatoform-disorders-a-routine-outcome-monitoring-study-in-secondary-psychiatric-care
#5
I V E Carlier, D H Andree Wiltens, Y R van Rood, T van Veen, J Dekker, A M van Hemert
AIM: Somatoform disorders are common and often chronic. It would be helpful to distinguish those patients who are likely to have a positive treatment course from those who are likely to follow a negative course. Such studies of different somatoform disorders are scarce, especially in secondary psychiatric care. This study examined the 6-month treatment course of psychological, physical symptoms, and functioning, and its predictors in a naturalistic sample of secondary psychiatric care outpatients with somatoform disorders...
March 23, 2018: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/29545081/effect-of-organisational-factors-on-the-variation-in-incidence-of-delirium-in-intensive-care-unit-patients-a-systematic-review-and-meta-regression-analysis
#6
REVIEW
Paul Rood, Getty Huisman-de Waal, Hester Vermeulen, Lisette Schoonhoven, Peter Pickkers, Mark van den Boogaard
BACKGROUND: Delirium occurs frequently in intensive care unit (ICU) patients and is associated with numerous deleterious outcomes. There is a large variation in reported delirium occurrence rates, ranging from 4% to 89%. Apart from patient and treatment-related factors, organisational factors could influence delirium incidence, but this is currently unknown. OBJECTIVE: To systematically review delirium incidence and determine whether or not organisational factors may contribute to the observed delirium incidence in adult ICU patients...
March 12, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29496769/feasibility-of-cognitive-training-in-critically-ill-patients-a-pilot-study
#7
Annelies Wassenaar, Paul Rood, Danielle Boelen, Lisette Schoonhoven, Peter Pickkers, Mark van den Boogaard
BACKGROUND: Delirium occurs frequently in the intensive care unit and is associated with detrimental consequences. Cognitive training is a promising, nonpharmacologic, preventive intervention, but it is unknown whether cognitive training is feasible for patients in intensive care units. OBJECTIVES: To examine the feasibility for both nurses and patients of using cognitive training exercises for intensive care unit patients. METHODS: A pilot study of a set of cognitive training exercises in a large, academic intensive care unit...
March 2018: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/29247351/round-the-clock-performance-of-coronary-ct-angiography-for-suspected-acute-coronary-syndrome-results-from-the-beacon-trial
#8
Marisa M Lubbers, Admir Dedic, Akira Kurata, Marcel Dijkshoorn, Jeroen Schaap, Jeroen Lammers, Evert J Lamfers, Benno J Rensing, Richard L Braam, Hendrik M Nathoe, Johannes C Post, Pleunie P Rood, Carl J Schultz, Adriaan Moelker, Mohamed Ouhlous, Bas M van Dalen, Eric Boersma, Koen Nieman
OBJECTIVE: To assess the image quality of coronary CT angiography (CCTA) for suspected acute coronary syndrome (ACS) outside office hours. METHODS: Patients with symptoms suggestive of an ACS underwent CCTA at the emergency department 24 hours, 7 days a week. A total of 118 patients, of whom 89 (75 %) presented during office hours (weekdays between 07:00 and 17:00) and 29 (25 %) outside office hours (weekdays between 17:00 and 07:00, weekends and holidays) underwent CCTA...
December 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29209062/jon-van-rood-1926-2017
#9
C Mueller, C Bonini, L Foeken, C Chabannon, A Bondanza, K Fleischhauer, A Velardi, N Kröger, J Kuball, M Mohty
No abstract text is available yet for this article.
December 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29192572/-recognising-postoperative-delirium-in-the-elderly
#10
T Numan, M van den Boogaard, A M Kampen, P J T Rood, L M Peelen, A J C Slooter
OBJECTIVE: To determine the degree of agreement between delirium experts on the diagnosis of delirium based on exactly the same information, and to assess the sensitivity of delirium screening methods used by clinical nurses. DESIGN: Prospective observational longitudinal study. METHOD: Older patients (≥ 60 years) who underwent major surgery were included. During the first three days after surgery they had a standardised cognitive screening test which was recorded on video...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29139203/jon-van-rood
#11
(no author information available yet)
No abstract text is available yet for this article.
December 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29034478/obituary-prof-johannes-joseph-van-rood-1926-2017
#12
A Brand, F H J Claas, R E Bontrop, R R P de Vries
No abstract text is available yet for this article.
January 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29025490/defining-the-research-agenda-to-measure-and-reduce-tuberculosis-stigmas
#13
K Macintyre, M I Bakker, S Bergson, R Bhavaraju, V Bond, J Chikovore, C Colvin, G M Craig, A L Cremers, A Daftary, N Engel, N Ferris France, E Jaramillo, M Kimerling, A Kipp, S Krishnaratne, C Mergenthaler, M Ngicho, L Redwood, E J J Rood, N Sommerland, A Stangl, A van Rie, W van Brakel, E Wouters, A Zwerling, E M H Mitchell
Crucial to finding and treating the 4 million tuberculosis (TB) patients currently missed by national TB programmes, TB stigma is receiving well-deserved and long-delayed attention at the global level. However, the ability to measure and evaluate the success of TB stigma-reduction efforts is limited by the need for additional tools. At a 2016 TB stigma-measurement meeting held in The Hague, The Netherlands, stigma experts discussed and proposed a research agenda around four themes: 1) drivers: what are the main drivers and domains of TB stigma(s)?; 2) consequences: how consequential are TB stigmas and how are negative impacts most felt?; 3) burden: what is the global prevalence and distribution of TB stigma(s) and what explains any variation? 4): intervention: what can be done to reduce the extent and impact of TB stigma(s)? Each theme was further subdivided into research topics to be addressed to move the agenda forward...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28991248/johannes-joseph-van-rood-pioneer-in-immuno-genetics-7-april-1926-21-july-2017
#14
W Fibbe, R P Gale
No abstract text is available yet for this article.
November 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28947279/kidney-allocation-based-on-proven-acceptable-antigens-results-in-superior-graft-survival-in-highly-sensitized-patients
#15
Sebastiaan Heidt, Geert W Haasnoot, Jon J van Rood, Marian D Witvliet, Frans H J Claas
Highly sensitized renal transplant candidates accumulate on transplant waiting lists since they produce antibodies to many HLA antigens, which in this way become unacceptable. Organ allocation to these patients is usually based on avoiding transplantation of organs bearing these unacceptable antigens. In contrast, allocation through the Eurotransplant Acceptable Mismatch (AM) program is based on extension of the patient's own HLA type with so-called acceptable HLA antigens to which strictly no antibodies are formed, as shown by extensive laboratory testing...
February 2018: Kidney International
https://www.readbyqxmd.com/read/28880498/prof-dr-johannes-joseph-van-rood-1926-2017
#16
R E Bontrop, A Brand, F H J Claas
No abstract text is available yet for this article.
October 2017: HLA
https://www.readbyqxmd.com/read/28860656/johannes-joseph-van-rood-pioneer-in-immuno-genetics-7-april-1926-21-july-2017
#17
W Fibbe, R P Gale
No abstract text is available yet for this article.
November 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28855345/workflow-and-factors-associated-with-delay-in-the-delivery-of-intra-arterial-treatment-for-acute-ischemic-stroke-in-the-mr-clean-trial
#18
Esmee Venema, Nikki Boodt, Olvert A Berkhemer, Pleunie P M Rood, Wim H van Zwam, Robert J van Oostenbrugge, Aad van der Lugt, Yvo B W E M Roos, Charles B L M Majoie, Hester F Lingsma, Diederik W J Dippel
OBJECTIVE: The effect of intra-arterial treatment (IAT) for acute ischemic stroke is highly time-dependent. We investigated the delay of IAT and factors associated with such delay. METHODS: MR CLEAN was a randomized trial of IAT plus usual care versus usual care alone (n=500). With multivariable linear regression, we analyzed the effect of intravenous treatment, general anesthesia, off-hours and inter-hospital transfer on time to admission to the emergency department (ED) of the intervention center and time to treatment...
August 30, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28835969/in-memoriam-johannes-joseph-van-rood-1926-2017
#19
Ronald Bontrop, Anneke Brand, Frans Claas
No abstract text is available yet for this article.
January 2018: Immunogenetics
https://www.readbyqxmd.com/read/28800338/a-guideline-for-parkinson-s-disease-nurse-specialists-with-recommendations-for-clinical-practice
#20
Herma Lennaerts, Marieke Groot, Berna Rood, Koen Gilissen, Hella Tulp, Erik van Wensen, Marten Munneke, Teus van Laar, Bastiaan R Bloem
BACKGROUND: Parkinson's Disease Nurse Specialists (PDNS) play an important role in the care for patients with Parkinson's disease (PD) and their caregivers. Until now, there were no nursing guidelines in PD, and interventions were based solely on daily clinical practice because there is no evidence to support the merits of nursing interventions. Consequently, there is little uniformity in current care delivery. OBJECTIVE: Developing a guideline for PDNS. METHODS: We developed a guideline based on a questionnaire among PDNS and a literature review, supplemented with expert opinion plus the input of patients and caregivers...
2017: Journal of Parkinson's Disease
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