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G. Klein

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https://www.readbyqxmd.com/read/29155880/molecular-characterization-of-novel-mosquito-borne-rickettsia-spp-from-mosquitoes-collected-at-the-demilitarized-zone-of-the-republic-of-korea
#1
Alice N Maina, Terry A Klein, Heung-Chul Kim, Sung-Tae Chong, Yu Yang, Kristin Mullins, Ju Jiang, Heidi St John, Richard G Jarman, Jun Hang, Allen L Richards
Rickettsiae are associated with a diverse range of invertebrate hosts. Of these, mosquitoes could emerge as one of the most important vectors because of their ability to transmit significant numbers of pathogens and parasites throughout the world. Recent studies have implicated Anopheles gambiae as a potential vector of Rickettsia felis. Herein we report that a metagenome sequencing study identified rickettsial sequence reads in culicine mosquitoes from the Republic of Korea. The detected rickettsiae were characterized by a genus-specific quantitative real-time PCR assay and sequencing of rrs, gltA, 17kDa, ompB, and sca4 genes...
2017: PloS One
https://www.readbyqxmd.com/read/29153485/morning-administration-of-0-4u-kg-day-insulin-glargine-300u-ml-provides-less-fluctuating-24-hour-pharmacodynamics-and-more-even-pharmacokinetic-profiles-compared-with-insulin-degludec-100u-ml-in-type-1-diabetes
#2
T S Bailey, J Pettus, R Roussel, W Schmider, M Maroccia, N Nassr, O Klein, G B Bolli, R Dahmen
AIM: To compare steady state pharmacodynamic and pharmacokinetic profiles of insulin glargine 300U/mL (Gla-300) with insulin degludec 100U/mL (Deg-100) in people with type 1 diabetes. METHODS: This single-centre, randomized, double-blind crossover euglycaemic clamp study included two parallel cohorts with fixed once-daily morning dose regimens. For both insulins participants received 0.4 (n=24) or 0.6U/kg/day (n=24), before breakfast, for 8 days prior to the clamp...
November 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29152524/young-adult-perceptions-surrounding-hookah-use
#3
Megan E Roberts, Elizabeth G Klein, Micah L Berman, Bilen Berhane, Amy K Ferketich
Objective: We aimed to improve understanding of young adults' perceptions and interpretations of the contexts surrounding use. Methods: We conducted focus groups with young adult hookah users (ages 18-28) to examine hookah-use experiences and risk perceptions. Results: Two dominant themes that emerged from the discussions were the social aspects of use (eg, "ending up" at a hookah café while out with friends), and the mental and physiological reactions to use (eg, relaxation and a "high" feeling)...
November 2017: Health Behavior and Policy Review
https://www.readbyqxmd.com/read/29150088/the-risk-of-remaining-silent-addressing-the-current-threats-to-women-s-health
#4
Claire D Brindis, Karen M Freund, Laura Baecher-Lind, C Noel Bairey Merz, Molly Carnes, Martha Gulati, Hadine Joffe, Wendy S Klein, Carolyn M Mazure, Lydia E Pace, Judith G Regensteiner, Rita F Redberg, Nanette Kass Wenger, Lorie Younger
No abstract text is available yet for this article.
November 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29148124/the-safety-of-live-attenuated-influenza-vaccine-in-children-and-adolescents-2-through-17%C3%A2-years-of-age-a-vaccine-safety-datalink-study
#5
Matthew F Daley, Christina L Clarke, Jason M Glanz, Stanley Xu, Simon J Hambidge, James G Donahue, James D Nordin, Nicola P Klein, Steven J Jacobsen, Allison L Naleway, Michael L Jackson, Grace Lee, Jonathan Duffy, Eric Weintraub
PURPOSE: To evaluate the safety of live attenuated influenza vaccine (LAIV) in children 2 through 17 years of age. METHODS: The study was conducted in 6 large integrated health care organizations participating in the Vaccine Safety Datalink (VSD). Trivalent LAIV safety was assessed in children who received LAIV between September 1, 2003 and March 31, 2013. Eighteen pre-specified adverse event groups were studied, including allergic, autoimmune, neurologic, respiratory, and infectious conditions...
November 17, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29146853/genome-sequences-of-four-subcluster-l2-mycobacterium-phages-finemlucis-miley16-wilder-and-zakai
#6
Christopher D Herren, Alexandra Peister, Timothy S Breton, Maggie S Hill, Marcy S Anderson, Adeline W Chang, Sydney B Klein, Mackenzie M Thornton, Stacy J Vars, Kasey E Wagner, Paige L Wiebe, Thomas G Williams, Coraima P Yanez, Jasanta M Ackles, Darius Artis, Ryan J Brazier, Ronald J Bryant, Kerel O Callwood, Isaiah H Carter, Cameron L DeBose, Christian D Edwards, Isaiah C Ezemba, Renshal R Joaquin, Zakai M Meghoo-Peddie, Ziha G Meghoo-Peddie, Ryan W Moore, Christopher E Smith, Adam J Turner, Raymond L Vorters, Jeffrey J Wider, Liesel L Krout, Mia S Comis, Madison J Davick, Eli E Michaud, Bailey E Shevenell, Sarah E Stanley, Chelsey I Frank, Jacob R Montgomery, Lawrence S Blumer, Jean A Doty, Martha Smith-Caldas, Welkin H Pope, Steven G Cresawn, Daniel A Russell, Rebecca A Garlena, Deborah Jacobs-Sera, Graham F Hatfull
Four subcluster L2 mycobacteriophages, Finemlucis, Miley16, Wilder, and Zakai, that infect Mycobacterium smegmatis mc(2)155 were isolated. The four phages are closely related to each other and code for 12 to 14 tRNAs and 130 to 132 putative protein-coding genes, including tyrosine integrases, cro, immunity repressors, and excise genes involved in the establishment of lysogeny.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29145936/biosimilars-state-of-clinical-and-regulatory-science
#7
Agnes Victoria Klein, Jian Wang, Brian G Feagan, Mark Omoto
On May 12, 2017, various issues and challenges associated with biologics were discussed during a session of the annual joint conference of Canadian Society for Pharmaceutical Sciences and Canadian Chapter of Controlled Release Society at Hyatt Regency Hotel, Montréal, QC, Canada.  An update on the Canadian regulatory guidelines for biosimilars was given, followed by viewpoints expressed by regulatory, academic and industry scientists.  Topics of discussion included: reference biologic drug, clinical considerations, immunogenicity, extrapolation and clarification of terminology, product monograph, international collaboration, switching and interchangeability, naming conventions, clinical and non-clinical evaluation, authorization of indications, statistical equivalence, the nor-switch study and biologics marketplace...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29145630/yaf9-subunit-of-the-nua4-and-swr1-complexes-targets-histone-h3k27ac-through-its-yeats-domain
#8
Brianna J Klein, Salar Ahmad, Kendra R Vann, Forest H Andrews, Zachary A Mayo, Gaelle Bourriquen, Joseph B Bridgers, Jinyong Zhang, Brian D Strahl, Jacques Côté, Tatiana G Kutateladze
Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound to the H3K27ac peptide reveals that the sequence C-terminal to K27ac stabilizes the complex. The side chain of K27ac inserts between two aromatic residues, mutation of which abrogates the interaction in vitro and leads in vivo to phenotypes similar to YAF9 deletion, including loss of SWR1-dependent incorporation of variant histone H2A...
November 14, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29138308/sex-reporting-in-preclinical-microbiological-and-immunological-research
#9
EDITORIAL
Tanvi Potluri, Kyrra Engle, Ashley L Fink, Landon G Vom Steeg, Sabra L Klein
Both sex (i.e., biological construct of male and female) and gender (i.e., social construct of masculine and feminine) impact the pathogenesis of diseases, including those caused by microbial infections. Following the 2015 NIH policy for consideration of sex as a biological variable in preclinical research, in 2018, authors of papers published in primary-research American Society for Microbiology (ASM) journals will be asked to report the sex of the research subjects and animals and of materials derived directly from them...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29134539/germline-variant-in-msx1-identified-in-a-dutch-family-with-clustering-of-barrett-s-esophagus-and-esophageal-adenocarcinoma
#10
A M J van Nistelrooij, R van Marion, W F J van Ijcken, A de Klein, A Wagner, K Biermann, M C W Spaander, J J B van Lanschot, W N M Dinjens, B P L Wijnhoven
The vast majority of esophageal adenocarcinoma cases are sporadic and caused by somatic mutations. However, over the last decades several families have been identified with clustering of Barrett's esophagus and esophageal adenocarcinoma. This observation suggests that one or more hereditary factors may play a role in the initiation of Barrett's esophagus and esophageal adenocarcinoma in these families. A Dutch family with clustering of Barrett's esophagus and esophageal adenocarcinoma was identified. Normal DNA obtained from the proband diagnosed with Barrett's esophagus was analyzed with SNP array and exome sequencing...
November 13, 2017: Familial Cancer
https://www.readbyqxmd.com/read/29132262/diastolic-dysfunction-is-common-in-survivors-of-pediatric-differentiated-thyroid-carcinoma
#11
Mariëlle Sanne Klein Hesselink, Gianni Bocca, Yoran M Hummel, Adrienne H Brouwers, Johannes G M Burgerhof, Eveline W C M van Dam, Jourik A Gietema, Bas Havekes, Marry M van den Heuvel-Eibrink, Eleonora P M Corssmit, Leontien Kremer, Romana Netea-Maier, Helena J H van der Pal, Robin Peeters, John Th M Plukker, Cécile M Ronckers, Hanneke M van Santen, Peter van der Meer, Thera P Links, Wim J E Tissing
INTRODUCTION: Whether pediatric patients with differentiated thyroid carcinoma (DTC) are at risk of developing treatment-related adverse effects on cardiac function is unknown. We therefore studied in long-term survivors of pediatric DTC the prevalence of cardiac dysfunction and atrial fibrillation (AF) in relation to treatment variables, and the association between cardiac dysfunction and plasma biomarkers. PATIENTS AND METHODS: In this nationwide prospective multicenter study, cardiac assessments were performed in 66 adult survivors of pediatric DTC (age at diagnosis ≤18 years and follow-up ≥5 years after diagnosis) treated in The Netherlands between 1970 and 2009...
November 13, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29122858/genome-sequences-of-chancellor-mitti-and-wintermute-three-subcluster-k4-phages-isolated-using-mycobacterium-smegmatis-mc-2-155
#12
Nicholas P Edgington, Stephanie M Voshell, Vassie C Ware, Francis F Akoto, Alexa A Alhout, Gurvina J Atwal, John B Balyozian, Zachary A Cadieux, Brianna M Chop, Steven G Cresawn, Netta Cudkevich, Dylan Z Faltine-Gonzalez, Rebecca A Garlena, Blair J Gilmer, Lee H Graham, Matthew S Grapel, Maaz M Haleem, Deborah Jacobs-Sera, Margaret A Kenna, Maryam A Khan, Taylor N Klein, Jamie B Korenberg, Brooke P Lichak, Catherine M Mageeney, Lauren N McKinley, Kourtney R Mendello, Cameron M Myers, Alexander T Nguyen, Bryan A Pasqualucci, Welkin H Pope, Lauren M Pyfer, Wascar A Ramirez, Julia R Reisner, Daniel A Russell, Paulene A Sapao, Virginia C Saux, Inderjeet Singh, Ty H Stoner, Rachel H Swope, Matthew J Thoonkuzhy, Madeleine L Walters, Lauren A Vargas, Croldy A Veliz, Kevin D Zhang, Caitlin M Zuilkoski, Graham F Hatfull
Mycobacteriophages Chancellor, Mitti, and Wintermute infect Mycobacterium smegmatis mc(2)155 and are closely related to phages Cheetobro and Fionnbharth in subcluster K4. Genome sizes range from 57,697 bp to 58,046 bp. Phages are predicted to be temperate and to infect the pathogen Mycobacterium tuberculosis.
November 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29120956/protein-kinase-c%C3%AE-deletion-causes-hypotension-and-decreased-vascular-contractility
#13
Brandi M Wynne, Cameron G McCarthy, Theodora Szasz, Patrick A Molina, Arlene B Chapman, R Clinton Webb, Janet D Klein, Robert S Hoover
AIM: Protein kinase Cα (PKCα) is a critical regulator of multiple cell signaling pathways including gene transcription, posttranslation modifications and activation/inhibition of many signaling kinases. In regards to the control of blood pressure, PKCα causes increased vascular smooth muscle contractility, while reducing cardiac contractility. In addition, PKCα has been shown to modulate nephron ion transport. However, the role of PKCα in modulating mean arterial pressure (MAP) has not been investigated...
November 8, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29117315/interdisciplinary-perspectives-on-sun-safety
#14
Alan C Geller, Nina G Jablonski, Sherry L Pagoto, Jennifer L Hay, Joel Hillhouse, David B Buller, W Larry Kenney, June K Robinson, Richard B Weller, Megan A Moreno, Barbara A Gilchrest, Craig Sinclair, Jamie Arndt, Jennifer M Taber, Kasey L Morris, Laura A Dwyer, Frank M Perna, William M P Klein, Jerry Suls
Overexposure to the sun is associated with an increased risk of melanoma and nonmelanoma skin cancer, but indications of improvements in sun protection behavior are poor. Attempts to identify emerging themes in skin cancer control have largely been driven by groups of experts from a single field. In December 2016, 19 experts from various disciplines convened for Interdisciplinary Perspectives on Skin Cancer, a 2-day meeting hosted by the National Academy of Sciences. The group discussed knowledge gaps, perspectives on sun exposure, implications for skin cancer risk and other health outcomes, and new directions...
November 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29106507/pedicled-and-free-flaps-for-intrathoracic-fistula-management
#15
Alba Fricke, Holger Bannasch, Henriette F Klein, Sebastian Wiesemann, Patrick Samson-Himmelstjerna, Bernward Passlick, Friedhelm Beyersdorf, Jens Hoeppner, Vincenzo Penna, Steffen U Eisenhardt, Björn G Stark, Georgios Koulaxouzidis
OBJECTIVES: Intrathoracic fistulae are among the potential sequelae of radiation therapy, empyema and abscess clearance and surgical tumour resections. Interdisciplinary plastic-reconstructive flap surgery is a helpful tool for the successful treatment of intrathoracic fistulae. METHODS: From February 2006 to April 2016, 13 patients (3 females and 10 males) underwent flap surgery for bronchial ( n  = 5), tracheal ( n  = 2), oesophageal ( n  = 2), post-pneumonectomy bronchopleural fistula ( n  = 2), tracheo-oesophageal ( n  = 1), gastrobronchial ( n  = 1) and oesophagobronchial ( n  = 1) fistulae...
July 4, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29100558/immunohaematological-complications-in-patients-with-sickle-cell-disease-after-haemopoietic-progenitor-cell-transplantation-a-prospective-single-centre-observational-study
#16
Elizabeth S Allen, Kshitij Srivastava, Matthew M Hsieh, Courtney D Fitzhugh, Harvey G Klein, John F Tisdale, Willy A Flegel
BACKGROUND: Haemopoietic progenitor cell (HPC) transplantation can cure sickle cell disease. Non-myeloablative conditioning typically results in donor-derived erythrocytes and stable mixed chimerism of recipient-derived and donor-derived leucocytes. Exposure to donor antigens from the HPC graft and new red cell antibodies induced by transfusion can lead to immunohaematological complications. We assessed the incidence of such complications among HPC transplant recipients with sickle cell disease...
November 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29098573/diet-and-exercise-a-match-made-in-bone
#17
REVIEW
Hubertine M E Willems, Ellen G H M van den Heuvel, Ruud J W Schoemaker, Jenneke Klein-Nulend, Astrid D Bakker
PURPOSE OF REVIEW: Multiple dietary components have the potential to positively affect bone mineral density in early life and reduce loss of bone mass with aging. In addition, regular weight-bearing physical activity has a strong positive effect on bone through activation of osteocyte signaling. We will explore possible synergistic effects of dietary components and mechanical stimuli for bone health by identifying dietary components that have the potential to alter the response of osteocytes to mechanical loading...
November 2, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29097536/finding-the-first-americans
#18
Todd J Braje, Tom D Dillehay, Jon M Erlandson, Richard G Klein, Torben C Rick
No abstract text is available yet for this article.
November 3, 2017: Science
https://www.readbyqxmd.com/read/29095554/patients-perceptions-of-their-doctors-notes-and-after-visit-summaries-a-mixed-methods-study-of-patients-at-safety-net-clinics
#19
Brittaney M Belyeu, Jared W Klein, Lisa M Reisch, Sue Peacock, Natalia V Oster, Joann G Elmore, Sara L Jackson
BACKGROUND: Patients are increasingly offered electronic access to their doctors' notes, and many consistently receive paper After-Visit Summaries. Specific feedback from patients about notes and summaries are lacking, particularly within safety-net settings. DESIGN: A mixed methods study SETTING AND PARTICIPANTS: Patients with poorly controlled diabetes attending two urban safety-net primary care clinics in Washington State. METHODS: Patients read their own most recent clinic note and After-Visit Summary, then completed a brief survey followed by a focus group discussion (3 groups in a large general medicine teaching clinic and 1 in an HIV/AIDS clinic) about their perceptions of the clinic note and After-Visit Summary...
November 2, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29089800/staging-and-surgical-approaches-in-gastric-cancer-a-clinical-practice-guideline
#20
N Coburn, R Cosby, L Klein, G Knight, R Malthaner, J Mamazza, C D Mercer, J Ringash
BACKGROUND: Resection is the cornerstone of cure for gastric adenocarcinoma; however, several aspects of surgical intervention remain controversial or are suboptimally applied at a population level, including staging, extent of lymphadenectomy (lnd), minimum number of lymph nodes that have to be assessed, gross resection margins, use of minimally invasive surgery, and relationship of surgical volumes with patient outcomes and resection in stage iv gastric cancer. METHODS: Literature searches were conducted in databases including medline (up to 10 June 2016), embase (up to week 24 of 2016), the Cochrane Library and various other practice guideline sites and guideline developer Web sites...
October 2017: Current Oncology
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