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G. Klein

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https://www.readbyqxmd.com/read/29793182/healthcare-provider-counseling-to-quit-smoking-and-patient-desire-to-quit-the-role-of-negative-smoking-outcome-expectancies
#1
Joan S Tucker, Brian D Stucky, Maria Orlando Edelen, William G Shadel, David J Klein
AIMS: The U.S. Public Health Service Clinical Practice Guideline on treating tobacco use and dependence recommends providing advice to quit to every tobacco user seen in a healthcare setting. However, the mechanism through which counseling encourages patients to quit has not been adequately studied. This study tests whether the association between receiving healthcare provider counseling and desire to quit is accounted for by negative health and psychosocial outcome expectancies of smoking...
May 21, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29792329/residual-complexity-does-impact-organic-chemistry-and-drug-discovery-the-case-of-rufomyazine-and-rufomycin
#2
Mary P Choules, Larry L Klein, David C Lankin, James B McAlpine, Sang-Hyun Cho, Jinhua Cheng, Hanki Lee, Joo-Won Suh, Birgit U Jaki, Scott G Franzblau, Guido F Pauli
Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromatographic separation methods. The new diketopiperazine, rufomyazine (6), and the previously known antibiotic, rufomycin (7), represent a prototypical case of RC that (almost) resulted in the misassignment of biological activity. The case exemplifies that impurities well below the natural abundance of 13 C (1...
May 24, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29779027/association-of-pre-end-stage-renal-disease-hemoglobin-with-early-dialysis-outcomes
#3
Carola-Ellen Kleine, Melissa Soohoo, Omesh N Ranasinghe, Christina Park, Maria V Marroquin, Yoshitsugu Obi, Connie M Rhee, Hamid Moradi, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
BACKGROUND: Incident hemodialysis patients have a high mortality risk within the first months after dialysis initiation. Pre-end-stage renal disease (ESRD) factors like anemia management may impact early post-ESRD outcomes. Therefore, we evaluated the impact of pre-ESRD hemoglobin (Hgb) and pre-ESRD Hgb slope on post-ESRD mortality and hospitalization outcomes. METHODS: The study included 31,472 veterans transitioning to ESRD. Using Cox and negative binomial regression models, we evaluated the association of pre-ESRD Hgb and Hgb slope with 12-month post-ESRD all-cause and cardiovascular mortality and hospitalization rates using 4 levels of hierarchical multivariable adjustment, including erythropoietin use and kidney decline in slope models...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29776928/enrichment-of-clinically-relevant-organisms-in-spontaneous-preterm-delivered-placenta-and-reagent-contamination-across-all-clinical-groups-in-a-large-uk-pregnancy-cohort
#4
Lydia J Leon, Ronan Doyle, Ernest Diez-Benavente, Taane G Clark, Nigel Klein, Philip Stanier, Gudrun E Moore
In this study differences in the placental microbiota of term and preterm deliveries from a large UK pregnancy cohort were studied using 16S targeted amplicon sequencing. The impact of contamination from DNA extraction, PCR reagents, as well as those from delivery itself were also examined. A total of 400 placental samples from 256 singleton pregnancies were analysed and differences investigated between spontaneous preterm, non-spontaneous preterm, and term delivered placenta. DNA from recently delivered placenta was extracted, and screening for bacterial DNA was carried out using targeted sequencing of the 16S rRNA gene on the Illumina MiSeq platform...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29776107/investigation-of-a-chaotic-thermostat
#5
G J Morales
A numerical study is presented of a free particle interacting with a deterministic thermostat in which the usual friction force is supplemented with a fluctuating force that depends on the self-consistent damping coefficient associated with coupling to the heat bath. It is found that this addition results in a chaotic environment in which a particle self-heats from rest and moves in positive and negative directions, exhibiting a characteristic diffusive behavior. The frequency power spectrum of the dynamical quantities displays the exponential frequency dependence ubiquitous to chaotic dynamics...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29769258/anti-tumor-efficacy-of-a-novel-clk-inhibitor-via-targeting-rna-splicing-and-myc-dependent-vulnerability
#6
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
The modulation of pre-mRNA splicing is proposed as an attractive anti-neoplastic strategy, especially for the cancers that exhibit aberrant pre-mRNA splicing. Here, we discovered that T-025 functions as an orally available and potent inhibitor of Cdc2-like kinases (CLKs), evolutionally conserved kinases that facilitate exon recognition in the splicing machinery. Treatment with T-025 reduced CLK-dependent phosphorylation, resulting in the induction of skipped exons, cell death, and growth suppression in vitro and in vivo Further, through growth inhibitory characterization, we identified high CLK2 expression or MYC amplification as a sensitive-associated biomarker of T-025...
May 16, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29766266/-syncope-and-fitness-to-drive
#7
REVIEW
Hermann H Klein
Although medical students are rarely instructed in traffic medicine in Germany, they are obliged to inform their patients about their fitness to drive after having become a medical doctor. This article gives an overview on the fitness to drive for patients with syncope by referring to the driving license regulation and the current guidelines released by the department of traffic. The driving license regulation distinguishes between group 1 and group 2 drivers. Group 1 drivers drive vehicles with a total weight less than 3...
May 15, 2018: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29763818/associations-between-birth-outcomes-and-maternal-pm-2-5-exposure-in-shanghai-a-comparison-of-three-exposure-assessment-approaches
#8
Qingyang Xiao, Hanyi Chen, Matthew J Strickland, Haidong Kan, Howard H Chang, Mitchel Klein, Chen Yang, Xia Meng, Yang Liu
BACKGROUND: Few studies have estimated effects of maternal PM2.5 exposure on birth outcomes in China due to the lack of historical air pollution data. OBJECTIVES: We estimated the associations between maternal PM2.5 exposure and birth outcomes using gap-filled satellite estimates in Shanghai, China. METHODS: We obtained birth registration records of 132,783 singleton live births during 2011-2014 in Shanghai. PM2.5 exposures were assessed from satellite-derived estimates or central-site measurements...
May 12, 2018: Environment International
https://www.readbyqxmd.com/read/29760221/development-and-validation-of-a-prostate-cancer-genomic-signature-that-predicts-early-adt-treatment-response-following-radical-prostatectomy
#9
Mohammed Alshalalfa, R Jeffrey Karnes, Vidit Sharma, Voleak Choeurng, Hussam Al-Deen Ashab, Nicholas Erho, Bruce J Trock, Ashley E Ross, Kasra Yousefi, Harrison K Tsai, Shuang G Zhao, Jeffrey J Tosoian, Zaid Haddad, Mandeep Takhar, S Laura Chang, Daniel E Spratt, Firas Abdollah, Robert B Jenkins, Eric A Klein, Paul L Nguyen, Adam P Dicker, Robert B Den, Elai Davicioni, Felix Y Feng, Tamara L Lotan, Edward M Schaeffer
PURPOSE: Currently no genomic signature exists to distinguish men most likely to progress on adjuvant androgen deprivation therapy (ADT) after radical prostatectomy (RP) for high risk prostate cancer. Here we develop and validate a gene expression signature to predict response to postoperative ADT. EXPERIMENTAL DESIGN: A training set consisting of 284 RP patients was established after 1:1 propensity score matching metastasis between adjuvant-ADT(a-ADT) treated and no-ADT treated groups...
May 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29758360/single-ingestion-of-di-2-propylheptyl-phthalate-dphp-by-male-volunteers-dphp-in-blood-and-its-metabolites-in-blood-and-urine
#10
D Klein, W Kessler, C Pütz, B Semder, W Kirchinger, A Langsch, W Gries, R Otter, A K E Gallien, X Wurzenberger, J G Filser
Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2 mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metabolites in blood and urine of 6 male volunteers over time following ingestion of a single DPHP dose (0.7 mg/kg body weight). Concentration-time courses in blood were obtained up to 24 h for DPHP, mono-(2-propylheptyl) phthalate (MPHP), mono-(2-propyl-6-hydroxyheptyl) phthalate (OH-MPHP), and mono-(2-propyl-6-oxoheptyl) phthalate (oxo-MPHP); amounts excreted in urine were determined up to 46 h for MPHP, OH-MPHP, oxo-MPHP, and mono-(2-propyl-6-carboxyhexyl) phthalate (cx-MPHP)...
May 11, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29758327/oxidative-stress-in-aortas-of-patients-with-advanced-occlusive-and-aneurysmal-diseases
#11
Márcio L Lucas, Cristina C Carraro, Adriane Belló-Klein, Antônio N Kalil, Newton R Aerts, Fabiano B Carvalho, Marilda C Fernandes, Claudio G Zettler
BACKGROUND: Aortoiliac occlusive disease (AOD) and abdominal aortic aneurysm (AAA) are very important cardiovascular diseases that present different aspects of pathophysiology; however, oxidative stress and inflammatory response seem be relevant in both of them. Our objective was to evaluate oxidative damage and degree of inflammatory infiltrate in aortas of patients surgically treated of AOD and AAA. MATERIAL AND METHODS: Levels of reactive oxygen species (ROS), NADPH oxidase activity and myeloperoxidase (MPO) expression as so as nitrite levels and superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in aortas of patients with AOD (n=16) or AAA (n=14), while control group was formed by cadaveric organ donors (n=10)...
May 11, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29756910/search-for-high-mass-resonances-decaying-to-%C3%AF-%C3%AE-in-pp-collisions-at-sqrt-s-13-tev-with-the-atlas-detector
#12
M Aaboud, G Aad, B Abbott, O Abdinov, B Abeloos, S H Abidi, O S AbouZeid, N L Abraham, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, S Adachi, L Adamczyk, J Adelman, M Adersberger, T Adye, A A Affolder, Y Afik, C Agheorghiesei, J A Aguilar-Saavedra, S P Ahlen, F Ahmadov, G Aielli, S Akatsuka, T P A Åkesson, E Akilli, A V Akimov, G L Alberghi, J Albert, P Albicocco, M J Alconada Verzini, S Alderweireldt, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, T Alexopoulos, M Alhroob, B Ali, M Aliev, G Alimonti, J Alison, S P Alkire, C Allaire, B M M Allbrooke, B W Allen, P P Allport, A Aloisio, A Alonso, F Alonso, C Alpigiani, A A Alshehri, M I Alstaty, B Alvarez Gonzalez, D Álvarez Piqueras, M G Alviggi, B T Amadio, Y Amaral Coutinho, L Ambroz, C Amelung, D Amidei, S P Amor Dos Santos, S Amoroso, C S Amrouche, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, J K Anders, K J Anderson, A Andreazza, V Andrei, S Angelidakis, I Angelozzi, A Angerami, A V Anisenkov, A Annovi, C Antel, M T Anthony, M Antonelli, D J Antrim, F Anulli, M Aoki, L Aperio Bella, G Arabidze, Y Arai, J P Araque, V Araujo Ferraz, R Araujo Pereira, A T H Arce, R E Ardell, F A Arduh, J-F Arguin, S Argyropoulos, A J Armbruster, L J Armitage, O Arnaez, H Arnold, M Arratia, O Arslan, A Artamonov, G Artoni, S Artz, S Asai, N Asbah, A Ashkenazi, E M Asimakopoulou, L Asquith, K Assamagan, R Astalos, R J Atkin, M Atkinson, N B Atlay, K Augsten, G Avolio, R Avramidou, B Axen, M K Ayoub, G Azuelos, A E Baas, M J Baca, H Bachacou, K Bachas, M Backes, P Bagnaia, M Bahmani, H Bahrasemani, J T Baines, M Bajic, O K Baker, P J Bakker, D Bakshi Gupta, E M Baldin, P Balek, F Balli, W K Balunas, E Banas, A Bandyopadhyay, Sw Banerjee, A A E Bannoura, L Barak, W M Barbe, E L Barberio, D Barberis, M Barbero, T Barillari, M-S Barisits, J T Barkeloo, T Barklow, N Barlow, R Barnea, S L Barnes, B M Barnett, R M Barnett, Z Barnovska-Blenessy, A Baroncelli, G Barone, A J Barr, L Barranco Navarro, F Barreiro, J Barreiro Guimarães da Costa, R Bartoldus, A E Barton, P Bartos, A Basalaev, A Bassalat, R L Bates, S J Batista, J R Batley, M Battaglia, M Bauce, F Bauer, K T Bauer, H S Bawa, J B Beacham, M D Beattie, T Beau, P H Beauchemin, P Bechtle, H P Beck, H C Beck, K Becker, M Becker, C Becot, A J Beddall, A Beddall, V A Bednyakov, M Bedognetti, C P Bee, T A Beermann, M Begalli, M Begel, A Behera, J K Behr, A S Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, K Belotskiy, N L Belyaev, O Benary, D Benchekroun, M Bender, N Benekos, Y Benhammou, E Benhar Noccioli, J Benitez, D P Benjamin, M Benoit, J R Bensinger, S Bentvelsen, L Beresford, M Beretta, D Berge, E Bergeaas Kuutmann, N Berger, L J Bergsten, J Beringer, S Berlendis, N R Bernard, G Bernardi, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, G Bertoli, I A Bertram, C Bertsche, G J Besjes, O Bessidskaia Bylund, M Bessner, N Besson, A Bethani, S Bethke, A Betti, A J Bevan, J Beyer, R M Bianchi, O Biebel, D Biedermann, R Bielski, K Bierwagen, N V Biesuz, M Biglietti, T R V Billoud, M Bindi, A Bingul, C Bini, S Biondi, T Bisanz, C Bittrich, D M Bjergaard, J E Black, K M Black, R E Blair, T Blazek, I Bloch, C Blocker, A Blue, U Blumenschein, Dr Blunier, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C Bock, D Boerner, D Bogavac, A G Bogdanchikov, C Bohm, V Boisvert, P Bokan, T Bold, A S Boldyrev, A E Bolz, M Bomben, M Bona, J S Bonilla, M Boonekamp, A Borisov, G Borissov, J Bortfeldt, D Bortoletto, V Bortolotto, D Boscherini, M Bosman, J D Bossio Sola, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, S K Boutle, A Boveia, J Boyd, I R Boyko, A J Bozson, J Bracinik, N Brahimi, A Brandt, G Brandt, O Brandt, F Braren, U Bratzler, B Brau, J E Brau, W D Breaden Madden, K Brendlinger, A J Brennan, L Brenner, R Brenner, S Bressler, D L Briglin, T M Bristow, D Britton, D Britzger, I Brock, R Brock, G Brooijmans, T Brooks, W K Brooks, E Brost, J H Broughton, P A Bruckman de Renstrom, D Bruncko, A Bruni, G Bruni, L S Bruni, S Bruno, B H Brunt, M Bruschi, N Bruscino, P Bryant, L Bryngemark, T Buanes, Q Buat, P Buchholz, A G Buckley, I A Budagov, F Buehrer, M K Bugge, O Bulekov, D Bullock, T J Burch, S Burdin, C D Burgard, A M Burger, B Burghgrave, K Burka, S Burke, I Burmeister, J T P Burr, D Büscher, V Büscher, E Buschmann, P Bussey, J M Butler, C M Buttar, J M Butterworth, P Butti, W Buttinger, A Buzatu, A R Buzykaev, G Cabras, S Cabrera Urbán, D Caforio, H Cai, V M M Cairo, O Cakir, N Calace, P Calafiura, A Calandri, G Calderini, P Calfayan, G Callea, L P Caloba, S Calvente Lopez, D Calvet, S Calvet, T P Calvet, M Calvetti, R Camacho Toro, S Camarda, P Camarri, D Cameron, R Caminal Armadans, C Camincher, S Campana, M Campanelli, A Camplani, A Campoverde, V Canale, M Cano Bret, J Cantero, T Cao, Y Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R M Carbone, R Cardarelli, F Cardillo, I Carli, T Carli, G Carlino, B T Carlson, L Carminati, R M D Carney, S Caron, E Carquin, S Carrá, G D Carrillo-Montoya, D Casadei, M P Casado, A F Casha, M Casolino, D W Casper, R Castelijn, V Castillo Gimenez, N F Castro, A Catinaccio, J R Catmore, A Cattai, J Caudron, V Cavaliere, E Cavallaro, D Cavalli, M Cavalli-Sforza, V Cavasinni, E Celebi, F Ceradini, L Cerda Alberich, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, S K Chan, W S Chan, Y L Chan, P Chang, J D Chapman, D G Charlton, C C Chau, C A Chavez Barajas, S Che, A Chegwidden, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, C Chen, H Chen, J Chen, J Chen, S Chen, S Chen, X Chen, Y Chen, Y-H Chen, H C Cheng, H J Cheng, A Cheplakov, E Cheremushkina, R Cherkaoui El Moursli, E Cheu, K Cheung, L Chevalier, V Chiarella, G Chiarelli, G Chiodini, A S Chisholm, A Chitan, I Chiu, Y H Chiu, M V Chizhov, K Choi, A R Chomont, S Chouridou, Y S Chow, V Christodoulou, M C Chu, J Chudoba, A J Chuinard, J J Chwastowski, L Chytka, D Cinca, V Cindro, I A Cioară, A Ciocio, F Cirotto, Z H Citron, M Citterio, A Clark, M R Clark, P J Clark, R N Clarke, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Colasurdo, B Cole, A P Colijn, J Collot, P Conde Muiño, E Coniavitis, S H Connell, I A Connelly, S Constantinescu, F Conventi, A M Cooper-Sarkar, F Cormier, K J R Cormier, M Corradi, E E Corrigan, F Corriveau, A Cortes-Gonzalez, M J Costa, D Costanzo, G Cottin, G Cowan, B E Cox, J Crane, K Cranmer, S J Crawley, R A Creager, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, V Croft, G Crosetti, A Cueto, T Cuhadar Donszelmann, A R Cukierman, M Curatolo, J Cúth, S Czekierda, P Czodrowski, G D'amen, S D'Auria, L D'eramo, M D'Onofrio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, T Dado, S Dahbi, T Dai, O Dale, F Dallaire, C Dallapiccola, M Dam, J R Dandoy, M F Daneri, N P Dang, N S Dann, M Danninger, V Dao, G Darbo, S Darmora, O Dartsi, A Dattagupta, T Daubney, W Davey, C David, T Davidek, D R Davis, E Dawe, I Dawson, K De, R de Asmundis, A De Benedetti, S De Castro, S De Cecco, N De Groot, P de Jong, H De la Torre, F De Lorenzi, A De Maria, D De Pedis, A De Salvo, U De Sanctis, A De Santo, K De Vasconcelos Corga, J B De Vivie De Regie, C Debenedetti, D V Dedovich, N Dehghanian, M Del Gaudio, J Del Peso, D Delgove, F Deliot, C M Delitzsch, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, C Delporte, P A Delsart, D A DeMarco, S Demers, M Demichev, S P Denisov, D Denysiuk, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, C Deterre, K Dette, M R Devesa, P O Deviveiros, A Dewhurst, S Dhaliwal, F A Di Bello, A Di Ciaccio, L Di Ciaccio, W K Di Clemente, C Di Donato, A Di Girolamo, B Di Micco, R Di Nardo, K F Di Petrillo, A Di Simone, R Di Sipio, D Di Valentino, C Diaconu, M Diamond, F A Dias, T Dias do Vale, M A Diaz, J Dickinson, E B Diehl, J Dietrich, S Díez Cornell, A Dimitrievska, J Dingfelder, F Dittus, F Djama, T Djobava, J I Djuvsland, M A B do Vale, M Dobre, D Dodsworth, C Doglioni, J Dolejsi, Z Dolezal, M Donadelli, J Donini, J Dopke, A Doria, M T Dova, A T Doyle, E Drechsler, E Dreyer, T Dreyer, M Dris, Y Du, J Duarte-Campderros, F Dubinin, A Dubreuil, E Duchovni, G Duckeck, A Ducourthial, O A Ducu, D Duda, A Dudarev, A Chr Dudder, E M Duffield, L Duflot, M Dührssen, C Dulsen, M Dumancic, A E Dumitriu, A K Duncan, M Dunford, A Duperrin, H Duran Yildiz, M Düren, A Durglishvili, D Duschinger, B Dutta, D Duvnjak, M Dyndal, B S Dziedzic, C Eckardt, K M Ecker, R C Edgar, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, R El Kosseifi, V Ellajosyula, M Ellert, F Ellinghaus, A A Elliot, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, J S Ennis, M B Epland, J Erdmann, A Ereditato, S Errede, M Escalier, C Escobar, B Esposito, O Estrada Pastor, A I Etienvre, E Etzion, H Evans, A Ezhilov, M Ezzi, F Fabbri, L Fabbri, V Fabiani, G Facini, R M Fakhrutdinov, S Falciano, P J Falke, S Falke, J Faltova, Y Fang, M Fanti, A Farbin, A Farilla, E M Farina, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, M Faucci Giannelli, A Favareto, W J Fawcett, L Fayard, O L Fedin, W Fedorko, M Feickert, S Feigl, L Feligioni, C Feng, E J Feng, M Feng, M J Fenton, A B Fenyuk, L Feremenga, J Ferrando, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, F Fiedler, A Filipčič, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, C Fischer, J Fischer, W C Fisher, N Flaschel, I Fleck, P Fleischmann, R R M Fletcher, T Flick, B M Flierl, L M Flores, L R Flores Castillo, N Fomin, G T Forcolin, A Formica, F A Förster, A Forti, A G Foster, D Fournier, H Fox, S Fracchia, P Francavilla, M Franchini, S Franchino, D Francis, L Franconi, M Franklin, M Frate, M Fraternali, D Freeborn, S M Fressard-Batraneanu, B Freund, W S Freund, D Froidevaux, J A Frost, C Fukunaga, T Fusayasu, J Fuster, O Gabizon, A Gabrielli, A Gabrielli, G P Gach, S Gadatsch, S Gadomski, P Gadow, G Gagliardi, L G Gagnon, C Galea, B Galhardo, E J Gallas, B J Gallop, P Gallus, G Galster, R Gamboa Goni, K K Gan, S Ganguly, Y Gao, Y S Gao, F M Garay Walls, C García, J E García Navarro, J A García Pascual, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, K Gasnikova, A Gaudiello, G Gaudio, I L Gavrilenko, A Gavrilyuk, C Gay, G Gaycken, E N Gazis, C N P Gee, J Geisen, M Geisen, M P Geisler, K Gellerstedt, C Gemme, M H Genest, C Geng, S Gentile, C Gentsos, S George, D Gerbaudo, G Geßner, S Ghasemi, M Ghneimat, B Giacobbe, S Giagu, N Giangiacomi, P Giannetti, S M Gibson, M Gignac, D Gillberg, G Gilles, D M Gingrich, M P Giordani, F M Giorgi, P F Giraud, P Giromini, G Giugliarelli, D Giugni, F Giuli, M Giulini, S Gkaitatzis, I Gkialas, E L Gkougkousis, P Gkountoumis, L K Gladilin, C Glasman, J Glatzer, P C F Glaysher, A Glazov, M Goblirsch-Kolb, J Godlewski, S Goldfarb, T Golling, D Golubkov, A Gomes, R Gonçalo, R Goncalves Gama, G Gonella, L Gonella, A Gongadze, F Gonnella, J L Gonski, S González de la Hoz, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, B Gorini, E Gorini, A Gorišek, A T Goshaw, C Gössling, M I Gostkin, C A Gottardo, C R Goudet, D Goujdami, A G Goussiou, N Govender, C Goy, E Gozani, I Grabowska-Bold, P O J Gradin, E C Graham, J Gramling, E Gramstad, S Grancagnolo, V Gratchev, P M Gravila, C Gray, H M Gray, Z D Greenwood, C Grefe, K Gregersen, I M Gregor, P Grenier, K Grevtsov, J Griffiths, A A Grillo, K Grimm, S Grinstein, Ph Gris, J-F Grivaz, S Groh, E Gross, J Grosse-Knetter, G C Grossi, Z J Grout, A Grummer, L Guan, W Guan, J Guenther, A Guerguichon, F Guescini, D Guest, O Gueta, R Gugel, B Gui, T Guillemin, S Guindon, U Gul, C Gumpert, J Guo, W Guo, Y Guo, R Gupta, S Gurbuz, G Gustavino, B J Gutelman, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, C Guyot, M P Guzik, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, N Haddad, A Hadef, S Hageböck, M Hagihara, H Hakobyan, M Haleem, J Haley, G Halladjian, G D Hallewell, K Hamacher, P Hamal, K Hamano, A 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Serfon, L Serin, L Serkin, M Sessa, H Severini, T Šfiligoj, F Sforza, A Sfyrla, E Shabalina, J D Shahinian, N W Shaikh, L Y Shan, R Shang, J T Shank, M Shapiro, A Sharma, A S Sharma, P B Shatalov, K Shaw, S M Shaw, A Shcherbakova, C Y Shehu, Y Shen, N Sherafati, A D Sherman, P Sherwood, L Shi, S Shimizu, C O Shimmin, M Shimojima, I P J Shipsey, S Shirabe, M Shiyakova, J Shlomi, A Shmeleva, D Shoaleh Saadi, M J Shochet, S Shojaii, D R Shope, S Shrestha, E Shulga, P Sicho, A M Sickles, P E Sidebo, E Sideras Haddad, O Sidiropoulou, A Sidoti, F Siegert, Dj Sijacki, J Silva, M Silva, S B Silverstein, L Simic, S Simion, E Simioni, B Simmons, M Simon, P Sinervo, N B Sinev, M Sioli, G Siragusa, I Siral, S Yu Sivoklokov, J Sjölin, M B Skinner, P Skubic, M Slater, T Slavicek, M Slawinska, K Sliwa, R Slovak, V Smakhtin, B H Smart, J Smiesko, N Smirnov, S Yu Smirnov, Y Smirnov, L N Smirnova, O Smirnova, J W Smith, M N K Smith, R W Smith, M Smizanska, K Smolek, A A Snesarev, I M Snyder, S Snyder, R Sobie, F Socher, A M Soffa, A Soffer, A Søgaard, D A Soh, G Sokhrannyi, C A Solans Sanchez, M Solar, E Yu Soldatov, U Soldevila, A A Solodkov, A Soloshenko, O V Solovyanov, V Solovyev, P Sommer, H Son, W Song, A Sopczak, F Sopkova, D Sosa, C L Sotiropoulou, S Sottocornola, R Soualah, A M Soukharev, D South, B C Sowden, S Spagnolo, M Spalla, M Spangenberg, F Spanò, D Sperlich, F Spettel, T M Spieker, R Spighi, G Spigo, L A Spiller, M Spousta, A Stabile, R Stamen, S Stamm, E Stanecka, R W Stanek, C Stanescu, M M Stanitzki, B S Stapf, S Stapnes, E A Starchenko, G H Stark, J Stark, S H Stark, P Staroba, P Starovoitov, S Stärz, R Staszewski, M Stegler, P Steinberg, B Stelzer, H J Stelzer, O Stelzer-Chilton, H Stenzel, T J Stevenson, G A Stewart, M C Stockton, G Stoicea, P Stolte, S Stonjek, A Straessner, J Strandberg, S Strandberg, M Strauss, P Strizenec, R Ströhmer, D M Strom, R Stroynowski, A Strubig, S A Stucci, B Stugu, J Stupak, N A Styles, D Su, J Su, S Suchek, Y Sugaya, M Suk, V V Sulin, Dms Sultan, S Sultansoy, T Sumida, S Sun, X Sun, K Suruliz, C J E Suster, M R Sutton, S Suzuki, M Svatos, M Swiatlowski, S P Swift, A Sydorenko, I Sykora, T Sykora, D Ta, K Tackmann, J Taenzer, A Taffard, R Tafirout, E Tahirovic, N Taiblum, H Takai, R Takashima, E H Takasugi, K Takeda, T Takeshita, Y Takubo, M Talby, A A Talyshev, J Tanaka, M Tanaka, R Tanaka, R Tanioka, B B Tannenwald, S Tapia Araya, S Tapprogge, A T Tarek Abouelfadl Mohamed, S Tarem, G Tarna, G F Tartarelli, P Tas, M Tasevsky, T Tashiro, E Tassi, A Tavares Delgado, Y Tayalati, A C Taylor, A J Taylor, G N Taylor, P T E Taylor, W Taylor, P Teixeira-Dias, D Temple, H Ten Kate, P K Teng, J J Teoh, F Tepel, S Terada, K Terashi, J Terron, S Terzo, M Testa, R J Teuscher, S J Thais, T Theveneaux-Pelzer, F Thiele, J P Thomas, P D Thompson, A S Thompson, L A Thomsen, E Thomson, Y Tian, R E Ticse Torres, V O Tikhomirov, Yu A Tikhonov, S Timoshenko, P Tipton, S Tisserant, K Todome, S Todorova-Nova, S Todt, J Tojo, S Tokár, K Tokushuku, E Tolley, M Tomoto, L Tompkins, K Toms, B Tong, P Tornambe, E Torrence, H Torres, E Torró Pastor, C Tosciri, J Toth, F Touchard, D R Tovey, C J Treado, T Trefzger, F Tresoldi, A Tricoli, I M Trigger, S Trincaz-Duvoid, M F Tripiana, W Trischuk, B Trocmé, A Trofymov, C Troncon, M Trovatelli, F Trovato, L Truong, M Trzebinski, A Trzupek, F Tsai, K W Tsang, J C-L Tseng, P V Tsiareshka, N Tsirintanis, S Tsiskaridze, V Tsiskaridze, E G Tskhadadze, I I Tsukerman, V Tsulaia, S Tsuno, D Tsybychev, Y Tu, A Tudorache, V Tudorache, T T Tulbure, A N Tuna, S Turchikhin, D Turgeman, I Turk Cakir, R Turra, P M Tuts, G Ucchielli, I Ueda, M Ughetto, F Ukegawa, G Unal, A Undrus, G Unel, F C Ungaro, Y Unno, K Uno, J Urban, P Urquijo, P Urrejola, G Usai, J Usui, L Vacavant, V Vacek, B Vachon, K O H Vadla, A Vaidya, C Valderanis, E Valdes Santurio, M Valente, S Valentinetti, A Valero, L Valéry, R A Vallance, A Vallier, J A Valls Ferrer, T R Van Daalen, W Van Den Wollenberg, H van der Graaf, P van Gemmeren, J Van Nieuwkoop, I van Vulpen, M C van Woerden, M Vanadia, W Vandelli, A Vaniachine, P Vankov, R Vari, E W Varnes, C Varni, T Varol, D Varouchas, A Vartapetian, K E Varvell, J G Vasquez, G A Vasquez, F Vazeille, D Vazquez Furelos, T Vazquez Schroeder, J Veatch, V Vecchio, L M Veloce, F Veloso, S Veneziano, A Ventura, M Venturi, N Venturi, V Vercesi, M Verducci, C Vergis, W Verkerke, A T Vermeulen, J C Vermeulen, M C Vetterli, N Viaux Maira, O Viazlo, I Vichou, T Vickey, O E Vickey Boeriu, G H A Viehhauser, S Viel, L Vigani, M Villa, M Villaplana Perez, E Vilucchi, M G Vincter, V B Vinogradov, A Vishwakarma, C Vittori, I Vivarelli, S Vlachos, M Vogel, P Vokac, G Volpi, S E von Buddenbrock, E von Toerne, V Vorobel, K Vorobev, M Vos, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, R Vuillermet, I Vukotic, P Wagner, W Wagner, J Wagner-Kuhr, H Wahlberg, S Wahrmund, K Wakamiya, J Walder, R Walker, W Walkowiak, V Wallangen, A M Wang, C Wang, F Wang, H Wang, H Wang, J Wang, J Wang, Q Wang, R-J Wang, R Wang, R Wang, S M Wang, T Wang, W Wang, W Wang, Y Wang, Z Wang, C Wanotayaroj, A Warburton, C P Ward, D R Wardrope, A Washbrook, P M Watkins, A T Watson, M F Watson, G Watts, S Watts, B M Waugh, A F Webb, S Webb, C Weber, M S Weber, S M Weber, S A Weber, J S Webster, A R Weidberg, B Weinert, J Weingarten, M Weirich, C Weiser, P S Wells, T Wenaus, T Wengler, S Wenig, N Wermes, M D Werner, P Werner, M Wessels, T D Weston, K Whalen, N L Whallon, A M Wharton, A S White, A White, M J White, R White, D Whiteson, B W Whitmore, F J Wickens, W Wiedenmann, M Wielers, C Wiglesworth, L A M Wiik-Fuchs, A Wildauer, F Wilk, H G Wilkens, H H Williams, S Williams, C Willis, S Willocq, J A Wilson, I Wingerter-Seez, E Winkels, F Winklmeier, O J Winston, B T Winter, M Wittgen, M Wobisch, A Wolf, T M H Wolf, R Wolff, M W Wolter, H Wolters, V W S Wong, N L Woods, S D Worm, B K Wosiek, K W Wozniak, K Wraight, M Wu, S L Wu, X Wu, Y Wu, T R Wyatt, B M Wynne, S Xella, Z Xi, L Xia, D Xu, H Xu, L Xu, T Xu, W Xu, B Yabsley, S Yacoob, K Yajima, D P Yallup, D Yamaguchi, Y Yamaguchi, A Yamamoto, T Yamanaka, F Yamane, M Yamatani, T Yamazaki, Y Yamazaki, Z Yan, H Yang, H Yang, S Yang, Y Yang, Y Yang, Z Yang, W-M Yao, Y C Yap, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, I Yeletskikh, E Yigitbasi, E Yildirim, K Yorita, K Yoshihara, C Young, C J S Young, J Yu, J Yu, X Yue, S P Y Yuen, I Yusuff, B Zabinski, G Zacharis, R Zaidan, A M Zaitsev, N Zakharchuk, J Zalieckas, S Zambito, D Zanzi, C Zeitnitz, G Zemaityte, J C Zeng, Q Zeng, O Zenin, T Ženiš, D Zerwas, M Zgubič, D Zhang, D Zhang, F Zhang, G Zhang, H Zhang, J Zhang, L Zhang, L Zhang, M Zhang, P Zhang, R Zhang, R Zhang, X Zhang, Y Zhang, Z Zhang, X Zhao, Y Zhao, Z Zhao, A Zhemchugov, B Zhou, C Zhou, L Zhou, M Zhou, M Zhou, N Zhou, Y Zhou, C G Zhu, H Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, K Zhukov, V Zhulanov, A Zibell, D Zieminska, N I Zimine, S Zimmermann, Z Zinonos, M Zinser, M Ziolkowski, L Živković, G Zobernig, A Zoccoli, K Zoch, T G Zorbas, R Zou, M Zur Nedden, L Zwalinski
A search for high-mass resonances decaying to τν using proton-proton collisions at sqrt[s]=13  TeV produced by the Large Hadron Collider is presented. Only τ-lepton decays with hadrons in the final state are considered. The data were recorded with the ATLAS detector and correspond to an integrated luminosity of 36.1  fb^{-1}. No statistically significant excess above the standard model expectation is observed; model-independent upper limits are set on the visible τν production cross section. Heavy W^{'} bosons with masses less than 3...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756227/the-genetic-nomenclature-of-recessive-cerebellar-ataxias
#13
REVIEW
Malco Rossi, Mathieu Anheim, Alexandra Durr, Christine Klein, Michel Koenig, Matthis Synofzik, Connie Marras, Bart P van de Warrenburg
The recessive cerebellar ataxias are a large group of degenerative and metabolic disorders, the diagnostic management of which is difficult because of the enormous clinical and genetic heterogeneity. Because of several limitations, the current classification systems provide insufficient guidance for clinicians and researchers. Here, we propose a new nomenclature for the genetically confirmed recessive cerebellar ataxias according to the principles and criteria laid down by the International Parkinson and Movement Disorder Society Task Force on Classification and Nomenclature of Genetic Movement Disorders...
May 14, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29748175/long-term-exposure-to-very-low-doses-of-bisphenol-s-affects-female-reproduction
#14
Jan Nevoral, Yaroslav Kolinko, Jiri Moravec, Tereza Zalmanova, Kristyna Hoskova, Sarka Prokesova, Pavel Klein, Kamar Ghaibour, Petr Hosek, Miriam Stiavnicka, Hedvika Rimnacova, Zbynek Tonar, Jaroslav Petr, Milena Kralickova
Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used BPA; however, its harmnessless is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. 4-week-old ICR females (N = 16 in each experimental group) were exposed to vehicle control (VC), BPS1 (0.001 ng BPS . g bw-1 . day-1), BPS2 (0.1 ng ...
May 10, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29747668/magnitude-processing-of-symbolic-and-non-symbolic-proportions-an-fmri-study
#15
Julia Mock, Stefan Huber, Johannes Bloechle, Julia F Dietrich, Julia Bahnmueller, Johannes Rennig, Elise Klein, Korbinian Moeller
BACKGROUND: Recent research indicates that processing proportion magnitude is associated with activation in the intraparietal sulcus. Thus, brain areas associated with the processing of numbers (i.e., absolute magnitude) were activated during processing symbolic fractions as well as non-symbolic proportions. Here, we investigated systematically the cognitive processing of symbolic (e.g., fractions and decimals) and non-symbolic proportions (e.g., dot patterns and pie charts) in a two-stage procedure...
May 10, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29745680/associations-of-perceived-norms-with-intentions-to-learn-genomic-sequencing-results-roles-for-attitudes-and-ambivalence
#16
Allecia E Reid, Jennifer M Taber, Rebecca A Ferrer, Barbara B Biesecker, Katie L Lewis, Leslie G Biesecker, William M P Klein
OBJECTIVE: Genomic sequencing is becoming increasingly accessible, highlighting the need to understand the social and psychological factors that drive interest in receiving testing results. These decisions may depend on perceived descriptive norms (how most others behave) and injunctive norms (what is approved of by others). We predicted that descriptive norms would be directly associated with intentions to learn genomic sequencing results, whereas injunctive norms would be associated indirectly, via attitudes...
May 10, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/29742584/predictive-validity-of-sepsis-3-definitions-and-sepsis-outcomes-in-critically-ill-patients-a-cohort-study-in-49-icus-in-argentina
#17
Elisa Estenssoro, Vanina S Kanoore Edul, Cecilia I Loudet, Javier Osatnik, Fernando G Ríos, Daniela N Vázquez, Mario O Pozo, Bernardo Lattanzio, Fernando Pálizas, Francisco Klein, Damián Piezny, Paolo N Rubatto Birri, Graciela Tuhay, Anatilde Díaz, Analía Santamaría, Graciela Zakalik, Arnaldo Dubin
OBJECTIVES: The new Sepsis-3 definitions have been scarcely assessed in low- and middle-income countries; besides, regional information of sepsis outcomes is sparse. Our objective was to evaluate Sepsis-3 definition performance in Argentina. DESIGN: Cohort study of 3-month duration beginning on July 1, 2016. SETTINGS: Forty-nine ICUs. PATIENTS: Consecutive patients admitted to the ICU with suspected infection that triggered blood cultures and antibiotic administration...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29738854/age-related-changes-in-female-mouse-cortical-bone-microporosity
#18
Haniyeh Hemmatian, Michaël R Laurent, Astrid D Bakker, Dirk Vanderschueren, Jenneke Klein-Nulend, G Harry van Lenthe
Osteocyte lacunae are small cavities within the bone matrix. Their dimensions and spatial arrangement affect bone mechanical properties. Furthermore, their size and shape affect the strain in bone tissue close to the lacunae; hence, they are supposed to affect the mechanosensory function of the osteocytes residing in the lacunae. It was the purpose of this study to quantify the morphological features of osteocyte lacunae, whether these are affected by aging and whether these vary among different anatomical location...
May 5, 2018: Bone
https://www.readbyqxmd.com/read/29735157/neural-correlates-of-drug-biased-choice-in-currently-using-and-abstinent-individuals-with-cocaine-use-disorder
#19
Scott J Moeller, Anna Zilverstand, Anna B Konova, Prantik Kundu, Muhammad A Parvaz, Rebecca Preston-Campbell, Keren Bachi, Nelly Alia-Klein, Rita Z Goldstein
BACKGROUND: The choice for drugs over alternative reinforcers is a translational hallmark feature of drug addiction. The neural basis of such drug-biased choice is not well understood, particularly in individuals with protracted drug abstinence who cannot ethically participate in studies that offer drug-using opportunities. METHODS: We developed a functional magnetic resonance imaging drug-choice task to examine the choice for viewing drug-related images, rather than for actually consuming a drug...
May 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29734499/blood-perfusion-of-patellar-bone-measured-by-dynamic-contrast-enhanced-mri-in-patients-with-patellofemoral-pain-a-case-control-study
#20
Rianne A van der Heijden, Dirk H J Poot, Melek Ekinci, Gyula Kotek, Peter L J van Veldhoven, Stefan Klein, Jan A N Verhaar, Gabriel P Krestin, Sita M A Bierma-Zeinstra, Marienke van Middelkoop, Edwin H G Oei
BACKGROUND: Altered perfusion might play an important role in the pathophysiology of patellofemoral pain (PFP), a common knee complaint with unclear pathophysiology. PURPOSE: To investigate differences in dynamic contrast-enhanced (DCE)-MRI perfusion parameters between patients with PFP and healthy control subjects. POPULATION/SUBJECTS/PHANTOM/SPECIMEN/ANIMAL MODEL: Thirty-five adult patients with PFP and 44 healthy adult control subjects...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
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