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G. Klein

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https://www.readbyqxmd.com/read/28931587/maternal-choline-supplementation-modulates-placental-nutrient-transport-and-metabolism-in-late-gestation-of-mouse-pregnancy
#1
Sze Ting Cecilia Kwan, Julia H King, Jian Yan, Zhen Wang, Xinyin Jiang, Jason S Hutzler, Hallie R Klein, J Thomas Brenna, Mark S Roberson, Marie A Caudill
Background: Fetal growth is dependent on placental nutrient supply, which is influenced by placental perfusion and transporter abundance. Previous research indicates that adequate choline nutrition during pregnancy improves placental vascular development, supporting the hypothesis that choline may affect placental nutrient transport.Objective: The present study sought to determine the impact of maternal choline supplementation (MCS) on placental nutrient transporter abundance and nutrient metabolism during late gestation...
September 20, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28929401/making-time-estimation-of-internally-versus-externally-defined-durations
#2
Michael D Klein, Jennifer A Stolz
Most research on the topic of duration estimation has examined the mechanisms underlying estimation of durations that are demarcated by experimental stimuli. It is not clear whether the estimation of durations that are instead defined by our own mental processes (e.g., response times) is underlain by the same mechanisms. Across five experiments, we tested whether the pattern of interference between concurrent temporal and nontemporal tasks was similar for the two types of intervals. Duration estimation of externally defined intervals slowed performance on a concurrent equation verification task, regardless of whether participants were required to report their estimate by clicking within an analogue scale or by reproducing the duration...
September 19, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28926373/exposure-to-mobile-source-air-pollution-in-early-life-and-childhood-asthma-incidence-the-kaiser-air-pollution-and-pediatric-asthma-study
#3
Audrey Flak Pennington, Matthew J Strickland, Mitchel Klein, Xinxin Zhai, Josephine T Bates, Carolyn Drews-Botsch, Craig Hansen, Armistead G Russell, Paige E Tolbert, Lyndsey A Darrow
BACKGROUND: Early-life exposure to traffic-related air pollution exacerbates childhood asthma, but it is unclear what role it plays in asthma development. METHODS: The association between exposure to primary mobile source pollutants during pregnancy and during infancy and asthma incidence by ages 2 through 6 was examined in the Kaiser Air Pollution and Pediatric Asthma Study, a racially diverse birth cohort of 24,608 children born between 2000 and 2010 and insured by Kaiser Permanente Georgia...
September 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/28924982/flashback-1997-collection-of-hematopoietic-progenitor-cells-by-peripheral-blood-apheresis-after-stimulation-with-granulocyte-colony-stimulating-factor
#4
Willy A Flegel, Karen M Byrne, Harvey G Klein
No abstract text is available yet for this article.
September 18, 2017: Transfusion
https://www.readbyqxmd.com/read/28921380/relationship-between-drug-burden-and-physical-and-cognitive-functions-in-a-sample-of-nursing-home-patients-with-dementia
#5
L M J Sanders, T Hortobágyi, G van Staveren, K Taxis, F Boersma, H C Klein, W J R Bossers, C G Blankevoort, E J A Scherder, E A Van der Zee, M J G van Heuvelen
PURPOSE: The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical functions in a sample of patients with dementia. METHODS: Using performance-based tests, we measured physical and cognitive functions in 140 nursing home patients aged over 70 with all-cause dementia...
September 18, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28919441/a-unique-ph-dependent-recognition-of-methylated-histone-h3k4-by-pps-and-dido
#6
Adam H Tencer, Jovylyn Gatchalian, Brianna J Klein, Abid Khan, Yi Zhang, Brian D Strahl, Karel H M van Wely, Tatiana G Kutateladze
The protein partner of Sans-fille (PPS) and its human homolog DIDO mediate diverse chromatin activities, including the regulation of stemness genes in embryonic stem cells and splicing in Drosophila. Here, we show that the PHD fingers of PPS and DIDO recognize the histone mark H3K4me3 in a pH-dependent manner: the binding is enhanced at high pH values but is decreased at low pH. Structural analysis reveals that the pH dependency is due to the presence of a histidine residue in the K4me3-binding aromatic cage of PPS...
September 8, 2017: Structure
https://www.readbyqxmd.com/read/28917536/birth-outcomes-following-immunization-of-pregnant-women-with-pandemic-h1n1-influenza-vaccine-2009-2010
#7
Abigail Eaton, Ned Lewis, Bruce Fireman, John Hansen, Roger Baxter, Julianne Gee, Nicola P Klein
BACKGROUND: Following the H1N1 influenza pandemic in 2009, pregnant women were recommended to receive both seasonal (TIV) and H1N1 influenza vaccines. This study presents incidence of adverse birth and pregnancy outcomes among a population of pregnant women immunized with TIV and H1N1 vaccines at Kaiser Permanente Northern California during 2009-2010. METHODS: We telephone surveyed pregnant Kaiser Permanente Northern California members to assess non-medically-attended reactions following H1N1, TIV or both vaccines during 2009-2010 (n=5365) in a separate study...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28917295/association-of-spontaneous-abortion-with-receipt-of-inactivated-influenza-vaccine-containing-h1n1pdm09-in-2010-11-and-2011-12
#8
James G Donahue, Burney A Kieke, Jennifer P King, Frank DeStefano, Maria A Mascola, Stephanie A Irving, T Craig Cheetham, Jason M Glanz, Lisa A Jackson, Nicola P Klein, Allison L Naleway, Eric Weintraub, Edward A Belongia
INTRODUCTION: Inactivated influenza vaccine is recommended in any stage of pregnancy, but evidence of safety in early pregnancy is limited, including for vaccines containing A/H1N1pdm2009 (pH1N1) antigen. We sought to determine if receipt of vaccine containing pH1N1 was associated with spontaneous abortion (SAB). METHODS: We conducted a case-control study over two influenza seasons (2010-11, 2011-12) in the Vaccine Safety Datalink. Cases had SAB and controls had live births or stillbirths and were matched on site, date of last menstrual period, and age...
September 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28912476/enstrophy-transport-conditional-on-local-flow-topologies-in-different-regimes-of-premixed-turbulent-combustion
#9
Vassilios Papapostolou, Daniel H Wacks, Nilanjan Chakraborty, Markus Klein, Hong G Im
Enstrophy is an intrinsic feature of turbulent flows, and its transport properties are essential for the understanding of premixed flame-turbulence interaction. The interrelation between the enstrophy transport and flow topologies, which can be assigned to eight categories based on the three invariants of the velocity-gradient tensor, has been analysed here. The enstrophy transport conditional on flow topologies in turbulent premixed flames has been analysed using a Direct Numerical Simulation database representing the corrugated flamelets (CF), thin reaction zones (TRZ) and broken reaction zones (BRZ) combustion regimes...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28902467/eaaci-guidelines-on-allergen-immunotherapy-prevention-of-allergy
#10
REVIEW
Susanne Halken, Desiree Larenas-Linnemann, Graham Roberts, Moises A Calderón, Elisabeth Angier, Oliver Pfaar, Dermot D Ryan, Ioana Agache, Ignacio J I J Ansotegui, Stefania Arasi, George Du Toit, Montserrat Fernandez-Rivas, Roy Geerth van Wijk, Marek Jutel, Jörg Kleine-Tebbe, Susanne Lau, Paolo M Matricardi, Giovanni B Pajno, Nikolaos G Papadopoulos, Martin Penagos, Alexandra F Santos, Gunter J Sturm, Frans Timmermans, R Van Ree, Eva-Maria Varga, Ulrich Wahn, Maria Kristiansen, Sangeeta Dhami, Aziz Sheikh, Muraro Antonella
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease-modifying treatment for IgE-mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence-based recommendations for AIT for prevention of i) development of allergic comorbidities in those with established allergic diseases, ii) development of first allergic condition and iii) allergic sensitization...
September 13, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28899100/rust-and-thinning-management-effect-on-cup-quality-and-plant-performance-for-two-cultivars-of-coffea-arabica-l
#11
Fabian Echeverria-Beirute, Seth C Murray, Patricia Klein, Chris Kerth, Rhonda Miller, Benoit Bertrand
Beverage quality is a complex attribute of coffee (Coffea arabica L.). Genotype (G), environment (E), management (M), post-harvest processing, and roasting are all involved. However, little is known about how G x M interactions influence beverage quality. We investigated how yield and coffee leaf rust disease (CLR) (Hemileia vastatrix Berk. et Br.) management affect cup quality and plant performance, in two coffee cultivars. Sensory and chemical analysis revealed that 10 of 70 attributes and 18 of 154 chemical volatile compounds were significantly affected by G and M...
September 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28892256/possibility-of-quantitative-t2-mapping-mri-of-cartilage-near-metal-in-high-tibial-osteotomy-a-human-cadaver-study
#12
Joost Verschueren, Duncan E Meuffels, Esther E Bron, Stefan Klein, Gert-Jan Kleinrensink, Jan A N Verhaar, Sita M A Bierma-Zeinstra, Gabriel P Krestin, Piotr A Wielopolski, Max Reijman, Edwin H G Oei
T2-mapping is a widely used quantitative MRI technique in osteoarthritis research. An important challenge for its application in the context of high tibial osteotomy (HTO) is the presence of metallic fixation devices. In this study, we evaluated the possibility of performing T2-mapping after a HTO, by assessing the extent of magnetic susceptibility artifacts and the influence on T2 relaxation times caused by two commonly used fixation devices. T2-mapping with a 3D fast spin-echo sequence at 3 Tesla was performed on 11 human cadaveric knee joints before and after implantation of a titanium plate and screws (n = 5) or cobalt chrome staples(n = 6)...
September 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28891009/aging-osteocytes-and-mechanotransduction
#13
REVIEW
Haniyeh Hemmatian, Astrid D Bakker, Jenneke Klein-Nulend, G Harry van Lenthe
PURPOSE OF REVIEW: The bone is able to adapt its structure to mechanical signals via the bone remodeling process governed by mechanosensitive osteocytes. With aging, an imbalance in bone remodeling results in osteoporosis. In this review, we hypothesized that changes in lacunar morphology underlie the decreased bone mechanoresponsiveness to mechanical loading with aging. RECENT FINDINGS: Several studies have reported considerable variations in the shape of osteocytes and their lacunae with aging...
September 11, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28889355/tingenone-a-pentacyclic-triterpene-induces-peripheral-antinociception-due-to-cannabinoid-receptors-activation-in-mice
#14
C C Veloso, R C M Ferreira, V G Rodrigues, L P Duarte, A Klein, I D Duarte, T R L Romero, A C Perez
Several works have shown that triterpenes induce peripheral antinociception by activation of cannabinoid receptors and endocannabinoids; besides, several research groups have reported activation of cannabinoid receptors in peripheral antinociception. The aim of this study was to assess the involvement of the cannabinoid system in the antinociceptive effect induced by tingenone against hyperalgesia evoked by prostaglandin E2 (PGE2) at peripheral level. The paw pressure test was used and the hyperalgesia was induced by intraplantar injection of PGE2 (2 μg/paw)...
September 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28888669/thyroid-hormones-decrease-the-proinflammatory-tlr4-nf-%C3%AE%C2%BA%C3%AE-pathway-and-improve-functional-parameters-of-the-left-ventricle-of-infarcted-rats
#15
Alexandre Luz de Castro, Rafael Oliveira Fernandes, Vanessa D Ortiz, Cristina Campos, Jéssica H P Bonetto, Tânia Regina G Fernandes, Adriana Conzatti, Rafaela Siqueira, Angela Vicente Tavares, Adriane Belló-Klein, Alex Sander da Rosa Araujo
Myocardial infarction leads to oxidative stress and promotes activation of the TLR4/NF-κβ proinflammatory pathway. Thyroid hormones (TH) are known to be cardioprotective after infarction. However, there are no studies evaluating whether TH could modulate this pathway in the heart. This study aimed to verify the effect of thyroid hormones on the TLR4/NF-κβ pathway after myocardial infarction. Male Wistar rats were allocated into the following groups: Sham-operated (SHAM), sham-operated + TH (SHAMT), infarcted (AMI) and infarcted + TH (AMIT)...
September 6, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28887905/past-present-and-future-of-parkinson-s-disease-a-special-essay-on-the-200th-anniversary-of-the-shaking-palsy
#16
REVIEW
J A Obeso, M Stamelou, C G Goetz, W Poewe, A E Lang, D Weintraub, D Burn, G M Halliday, E Bezard, S Przedborski, S Lehericy, D J Brooks, J C Rothwell, M Hallett, M R DeLong, C Marras, C M Tanner, G W Ross, J W Langston, C Klein, V Bonifati, J Jankovic, A M Lozano, G Deuschl, H Bergman, E Tolosa, M Rodriguez-Violante, S Fahn, R B Postuma, D Berg, K Marek, D G Standaert, D J Surmeier, C W Olanow, J H Kordower, P Calabresi, A H V Schapira, A J Stoessl
This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority...
September 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28886980/-dose-constraints-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-small-bowel-and-duodenum
#17
F Goupy, E Chajon, J Castelli, É Le Prisé, L Duvergé, N Jaksic, G Vogin, É Monpetit, V Klein, L de Bosschère, P Maingon
Radiotherapy of abdominopelvic primary or secondary lesions in conformational or stereotactic techniques is in full development. The small bowel is highly sensitive to irradiation and is the main organ at risk limiting prescription doses. This literature review aims to define the dose constraints to the small bowel and the duodenum in conformational and stereotactic body radiotherapy. The small bowel including the duodenum, jejunum and ileum is delineated on the simulation scanner. The radio-induced intestinal toxicities are acute related to the cellular depopulation of the intestinal mucosa, and late of more complex pathophysiology associating depletion in stem cells, microangiopathy, chronic inflammation and fibrosis...
September 5, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28880359/-a-young-boy-with-periodic-strange-behavior-and-hypersomnia-kleine-levin-syndrome
#18
F Dauwe, L Imeraj, K Dhondt
Kleine-Levin syndrome is a rare neuro-psychiatric disease. Most of the young patients are males who present with hypersomnia, cognitive dysfunction, altered perception, eating disorder (e.g. hyperphagia) or disinhibited behaviour (e.g. hypersexuality). Psychiatric symptoms such as apathy, delusions and hallucinations, depressed mood and compulsive behaviours also appear often and result frequently in a psychiatric referral. These symptoms, however, should be distinguished from those of psychiatric diseases as early as possible in order to ensure that patients do not receive the wrong treatment...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28878067/tree-species-richness-attenuates-the-positive-relationship-between-mutualistic-ant-hemipteran-interactions-and-leaf-chewer-herbivory
#19
Andreas Schuldt, Felix Fornoff, Helge Bruelheide, Alexandra-Maria Klein, Michael Staab
Interactions across trophic levels influence plant diversity effects on ecosystem functions, but the complexity of these interactions remains poorly explored. For example, the interplay between different interactions (e.g. mutualism, predation) might be an important moderator of biodiversity-ecosystem function relationships. We tested for relationships between trophobioses (facultative ant-hemipteran mutualism) and leaf chewer herbivory in a subtropical forest biodiversity experiment. We analysed trophobiosis and herbivory data of more than 10 000 trees along a tree species richness gradient...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28877802/a-comprehensive-investigation-of-comorbidities-mechanisms-injury-patterns-and-outcomes-in-geriatric-blunt-trauma-patients
#20
COMPARATIVE STUDY
Carlos V R Brown, Kevin Rix, Amanda L Klein, Brent Ford, Pedro G R Teixeira, Jayson Aydelotte, Ben Coopwood, Sadia Ali
The geriatric population is growing and trauma providers are often tasked with caring for injuries in the elderly. There is limited information regarding injury patterns in geriatric trauma patients stratified by mechanism of injury. This study intends to investigate the comorbidities, mechanisms, injury patterns, and outcomes in geriatric blunt trauma patients. A retrospective study of the 2012 National Trauma Databank was performed. Adult blunt trauma patients were identified; geriatric (>/=65) patients were compared with younger (<65) patients regarding admission demographics and vital signs, mechanism and severity of injury, and comorbidities...
November 1, 2016: American Surgeon
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