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C. Little

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https://www.readbyqxmd.com/read/29245047/polyriboinosinic-polyribocytidylic-acid-facilitates-interleukin-6-and-interleukin-8-secretion-in-human-dermal-fibroblasts-via-the-jak-stat3-and-p38-mapk-signal-transduction-pathways
#1
Zhang Ying Zhu, Cong Zhuo Jia, Jian Min Luo, Li Wang
Polyriboinosinic-polyribocytidylic acid (polyI:C) is a viral dsRNA analoguethat promotes wounds healing, accelerates re-epithelialization, granulation and neovascularization, and induces pro-inflammatory cytokine release. Little is known about polyI:C mediated induction of inflammatory mediators in human dermal fibroblast (HDFs), which form the primary scaffold for epithelial cells covering the wound. Here, we found that polyI:C enhances IL-6 and IL-8 mRNA expression and induces of IL-6 and IL-8 production in a concentration-dependent and time-dependent manner in HDFs...
December 12, 2017: Cytokine
https://www.readbyqxmd.com/read/29244607/a-survey-of-risk-factors-for-digit-injuries-among-dogs-training-and-competing-in-agility-events
#2
Debra C Sellon, Katherine Martucci, John R Wenz, Denis J Marcellin-Little, Michelle Powers, Kimberley L Cullen
OBJECTIVE To identify potential risk factors for digit injuries in dogs training and competing in agility events. DESIGN Internet-based, retrospective, cross-sectional survey. ANIMALS 1,081 dogs training or competing in agility events. PROCEDURES Data were collected for eligible animals via retrospective surveys distributed electronically to handlers of dogs participating in agility-related activities. Variables evaluated included demographic (handlers) and signalment (dogs) information, physical characteristics of dogs, and injury characteristics...
January 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29244223/fixed-bearing-medial-unicompartmental-knee-arthroplasty-restores-neither-the-medial-pivoting-behavior-nor-the-ligament-forces-of-the-intact-knee-in-passive-flexion
#3
Mohammad Kia, Lucian C Warth, Joseph D Lipman, Timothy M Wright, Geoffrey H Westrich, Michael B Cross, David J Mayman, Andrew D Pearle, Carl W Imhauser
Medial unicompartmental knee arthroplasty (UKA) is an accepted treatment for isolated medial osteoarthritis. However, using an improper thickness for the tibial component may contribute to early failure of the prosthesis or disease progression in the unreplaced lateral compartment. Little is known of the effect of insert thickness on both knee kinematics and ligament forces. Therefore, a computational model of the tibiofemoral joint was used to determine how non-conforming, fixed bearing medial UKA affects tibiofemoral kinematics and tension in the medial collateral ligament (MCL) and the anterior cruciate ligament (ACL) during passive knee flexion...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29243827/one-incision-versus-two-incision-techniques-for-arthroscopically-assisted-anterior-cruciate-ligament-reconstruction-in-adults
#4
REVIEW
Fernando C Rezende, Vinícius Y Moraes, Carlos Es Franciozi, Pedro Debieux, Marcus V Luzo, João Carlos Belloti
BACKGROUND: Anterior cruciate ligament (ACL) tears are serious knee injuries that are frequently treated surgically in the form of arthroscopically assisted reconstruction with grafts from the patella or hamstrings tendons. We reviewed the evidence for the choice of arthroscopically assisted ACL reconstruction technique in terms of whether it should involve one incision (femoral tunnel drilled from inside the knee joint under arthroscopic visualisation) or two incisions (femoral tunnel drilled from outside to inside the knee joint)...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29243101/fractures-in-a-nationwide-population-based-cohort-of-users-of-breast-cancer-hormonal-therapy
#5
Joan M Neuner, Yushu Shi, Amanda L Kong, Sailaja Kamaraju, Elizabeth C Smith, Alicia J Smallwood, Purushottam W Laud, John A Charlson
PURPOSE: Although users of aromatase inhibitors have higher total fracture risk in some randomized trials, little is known about their risk outside of clinical trials or in older higher-risk cohorts. METHODS: In a population-based retrospective cohort study, we identified all older US Medicare D prescription drug insurance plan-enrolled women who had initial breast cancer surgery in 2006-2008 and began hormonal therapy (an aromatase inhibitor (AI) or tamoxifen) within the subsequent year...
December 15, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29243085/patterns-in-spatial-distribution-and-root-trait-syndromes-for-ecto-and-arbuscular-mycorrhizal-temperate-trees-in-a-mixed-broadleaf-forest
#6
Oscar J Valverde-Barrantes, Kurt A Smemo, Larry M Feinstein, Mark W Kershner, Christopher B Blackwood
Functional differences between trees with arbuscular (AM) or ectomycorrhizal (ECM) partnerships influence important ecological processes including nutrient cycling, community assembly, and biomass allocation patterns. Although most broadleaf temperate forests show both mycorrhizal types, relatively few studies have addressed functional difference among coexisting mycorrhizal tree species. The maintenance of ECM associations usually requires higher C investment than AM, leading to (A) lower root biomass and (B) more conservative root trait syndromes in ECM tree species compared to AM species...
December 14, 2017: Oecologia
https://www.readbyqxmd.com/read/29242807/parents-and-child-s-concussion-history-as-predictors-of-parental-attitudes-and-knowledge-of-concussion-recognition-and-response
#7
Melissa C Kay, Johna K Register-Mihalik, Cassie B Ford, Richelle M Williams, Tamara C Valovich McLeod
Background: Parents' knowledge of and attitudes toward concussions are often vital factors that affect care for injured adolescent athletes. It is important to understand the role that parents' personal experiences with concussions play with regard to current concussion knowledge and attitudes so that clinicians may tailor their educational approaches. Purpose/Hypothesis: The purpose of this study was to determine an association between parents' personal experiences and their child's experiences with concussions as well as parental concussion knowledge and attitudes...
December 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29242618/a-simple-platform-for-the-rapid-development-of-antimicrobials
#8
Stephen Albert Johnston, Valeriy Domenyuk, Nidhi Gupta, Milene Tavares Batista, John C Lainson, Zhan-Gong Zhao, Joel F Lusk, Andrey Loskutov, Zbigniew Cichacz, Phillip Stafford, Joseph Barten Legutki, Chris W Diehnelt
Recent infectious outbreaks highlight the need for platform technologies that can be quickly deployed to develop therapeutics needed to contain the outbreak. We present a simple concept for rapid development of new antimicrobials. The goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen. We tested the feasibility of a system based on antimicrobial synbodies. The system involves creating an array of 100 peptides that have been selected for broad capability to bind and/or kill viruses and bacteria...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242276/oral-sodium-butyrate-impacts-brain-metabolism-and-hippocampal-neurogenesis-with-limited-effects-on-gut-anatomy-and-function-in-pigs
#9
David Val-Laillet, Sylvie Guérin, Nicolas Coquery, Isabelle Nogret, Michèle Formal, Véronique Romé, Laurence Le Normand, Paul Meurice, Gwénaëlle Randuineau, Paul Guilloteau, Charles-Henri Malbert, Patricia Parnet, Jean-Paul Lallès, Jean-Pierre Segain
Butyrate can improve gut functions, whereas histone deacetylase inhibitors might alleviate neurocognitive alterations. Our aim was to assess whether oral butyrate could modulate brain metabolism and plasticity and if this would relate to gut function. Sixteen pigs were subjected to sodium butyrate (SB) supplementation via beverage water or water only [control (C)]. All pigs had blood sampled after 2 and 3 wk of treatment, and were subjected to a brain positron emission tomography after 3 wk. Animals were euthanized after 4 wk to sample pancreas, intestine, and brain for gut physiology and anatomy measurements, as well as hippocampal histology, Ki67, and doublecortin (DCX) immunohistochemistry...
December 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29242247/chip-regulates-aquaporin-2-quality-control-and-body-water-homeostasis
#10
Qi Wu, Hanne B Moeller, Donté A Stevens, Rebekah Sanchez-Hodge, Gabrielle Childers, Marleen L A Kortenoeven, Lei Cheng, Lena L Rosenbaek, Carrie Rubel, Cam Patterson, Trairak Pisitkun, Jonathan C Schisler, Robert A Fenton
The importance of the kidney distal convoluted tubule (DCT) and cortical collecting duct (CCD) is highlighted by various water and electrolyte disorders that arise when the unique transport properties of these segments are disturbed. Despite this critical role, little is known about which proteins have a regulatory role in these cells and how these cells can be regulated by individual physiologic stimuli. By combining proteomics, bioinformatics, and cell biology approaches, we found that the E3 ubiquitin ligase CHIP is highly expressed throughout the collecting duct; is modulated in abundance by vasopressin; interacts with aquaporin-2 (AQP2), Hsp70, and Hsc70; and can directly ubiquitylate the water channel AQP2 in vitro shRNA knockdown of CHIP in CCD cells increased AQP2 protein t1/2 and reduced AQP2 ubiquitylation, resulting in greater levels of AQP2 and phosphorylated AQP2...
December 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29242063/simple-classification-and-clinical-outcomes-of-angiographic-dissection-after-balloon-angioplasty-for-femoropopliteal-disease
#11
Norihiro Kobayashi, Keisuke Hirano, Masahiro Yamawaki, Motoharu Araki, Tsuyoshi Sakai, Yasunari Sakamoto, Shinsuke Mori, Masakazu Tsutsumi, Yohsuke Honda, Yoshiaki Ito
OBJECTIVE: Angiographic dissection is considered to be associated with restenosis. However, little is known about the impact of the severity of angiographic dissection on future restenosis. METHODS: A total of 319 consecutive de novo femoropopliteal lesions were treated by balloon angioplasty alone. All of these lesions were divided into three groups: group A, no angiographic dissection; group B, mild dissection, the width of the dissection was less than one-third of the lumen; and group C, severe dissection, the width of the dissection was more than one-third of the lumen...
December 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29242014/anti-ige-treatment-with-oral-immunotherapy-in-multifood-allergic-participants-a-double-blind-randomised-controlled-trial
#12
Sandra Andorf, Natasha Purington, Whitney M Block, Andrew J Long, Dana Tupa, Erica Brittain, Amanda Rudman Spergel, Manisha Desai, Stephen J Galli, Kari C Nadeau, R Sharon Chinthrajah
BACKGROUND: Despite progress in single food oral immunotherapy, there is little evidence concerning the safety and efficacy of treating individuals with multiple food (multifood) allergies. We did a pilot study testing whether anti-IgE (omalizumab) combined with multifood oral immunotherapy benefited multifood allergic patients. METHODS: We did a blinded, phase 2 clinical trial at Stanford University. We enrolled participants, aged 4-15 years, with multifood allergies validated by double-blind, placebo-controlled food challenges to their offending foods...
December 11, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29241992/educational-content-and-the-use-of-social-media-at-us-departments-of-surgery
#13
Vahagn C Nikolian, Meredith Barrett, Valeria S Valbuena, Andrew M Ibrahim, Hassan Eidy, Mohamed H Ghandour, Amir A Ghaferi
BACKGROUND: The growth of the social media platform Twitter has prompted many to consider its potential as an educational tool. Little is known about how surgery training programs are utilizing this resource and whether this platform can provide educational content effectively. We sought to determine national utilization of Twitter by departments of surgery in the United States and evaluate if educationally driven content heightened engagement with the Twitter followers. METHODS: We conducted a cross-sectional analysis of social media presence for all Accreditation Council for Graduation Medical Education accredited general surgery training programs between October 1, 2016 and December 31, 2016...
December 11, 2017: Surgery
https://www.readbyqxmd.com/read/29241947/effects-of-sublingual-glyceryl-trinitrate-administration-on-the-quality-of-preprocedure-ct-angiography-performed-to-plan-prostate-artery-embolization
#14
Mark W Little, Andrew C Macdonald, Phil Boardman, Mark J Bratby, Suzie Anthony, Mohammed Hadi, Charles R Tapping
PURPOSE: To determine the effects of sublingual glyceryl trinitrate (GTN) on the quality of planning computed tomography (CT) angiography performed prior to prostate artery embolization (PAE). MATERIALS AND METHODS: A retrospective cohort study was performed on patients who had previously undergone CT angiography before a procedure for PAE at our institution. Early CT angiography studies for PAE at our single center had initially been performed without GTN. These were compared to subsequent CT angiography studies that had been performed with GTN, after a previously implemented change in practice...
December 11, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29241430/past-year-treatment-utilization-among-individuals-meeting-dsm-5-ptsd-criteria-results-from-a-nationally-representative-sample
#15
Andrew C Hale, Rebecca K Sripada, Kipling M Bohnert
OBJECTIVE: Little is known regarding treatment utilization among individuals meeting DSM-5 criteria for posttraumatic stress disorder (PTSD). METHODS: Data were analyzed from the third wave of the National Epidemiologic Survey on Alcohol and Related Conditions, a nationally representative sample using DSM-5 criteria. RESULTS: Factors related to increased odds of PTSD treatment utilization for individuals meeting lifetime criteria included some college education versus less than a high school degree (odds ratio [OR]=3...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241405/cell-clusters-are-indicative-of-stem-cell-activity-in-the-degenerate-intervertebral-disc-can-their-properties-be-manipulated-to-improve-intrinsic-repair-of-the-disc
#16
Sharon Brown, Ajay Matta, William Mark Erwin, Sally Roberts, Helen H Gruber, Edward N Hanley, Christopher B Little, James Melrose
The aim of this study was to examine the complexity of the stem cell populations in the intervertebral disc (IVD) and understand their role in disc degeneration with a view to determining whether the resident stem cells could be developed for therapeutic purposes to combat IVD degeneration. Stem cells have been isolated from disc and paradiscal tissues including the notochord, annulus fibrosus (AF), nucleus pulposus (NP), cartilaginous endplate (CEP), ligamentum flavum and vertebral body. Resident AF and NP cells are relatively sparsely distributed occuring as single or occasional doublet cells surrounded by an extensive extracellular matrix (ECM)...
December 14, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29241162/in-vitro-and-in-vivo-activity-of-fomitopsis-pinicola-sw-ex-fr-karst-chloroform-fpkc-extract-against-s180-tumor-cells
#17
Ye Gao, Pan Wang, Yaqin Wang, Lijie Wu, Xiaobing Wang, Kun Zhang, Quanhong Liu
BACKGROUND/AIMS: Non-toxic fomitopsis is has been traditionally used in folk medicine in many countries for its anti-inflammatory and anti-vascular disease activities. The present study investigates the antitumor effect of Fomitopsis pinicola (Sw. Ex Fr.) Karst chloroform extract (FPKc) on S180 tumor cells in vitro and in vivo and we determined the underlying mechanisms. METHODS: HPLC was employed to analyze the constituents of FPKc. In-vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to quantify the growth inhibition of FPKc; Propidium iodide (PI) exclusion assay and scanning electron microscopy (SEM) were used to observe the damage on the cell membrane and the changes of the cell morphology; Staining with Hoechst 33342/propidium iodide (HO/PI) and the application of the Annexin V-FITC/PI analysis permitted to observe the cell death triggered by FPKc; DNA damage and cell cycle arrest were detected by flow cytometry; Rhodamine 123 (RH123) and Cytochrome C were used as dyes to investigate the alterations of the mitochondria...
December 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29241103/prevalence-and-correlates-of-benzodiazepine-use-and-misuse-among-young-adults-who-use-prescription-opioids-non-medically
#18
Benjamin A Bouvier, Katherine M Waye, Beth Elston, Scott E Hadland, Traci C Green, Brandon D L Marshall
BACKGROUND: Benzodiazepine use dramatically increases the risk of unintentional overdose among people who use opioids non-medically. However, little is known about the patterns of co-occurring benzodiazepine and opioid use among young adults in the United States. METHODS: The Rhode Island Young Adult Prescription Drug Study (RAPiDS) was a cross-sectional study from January 2015-February 2016. RAPiDS recruited 200 young adults aged 18-29 who reported past 30-day non-medical prescription opioid (NMPO) use...
December 7, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29241051/determination-of-lipid-profiles-in-serum-of-obese-ponies-before-and-after-weight-reduction-by-using-multi-one-dimensional-thin-layer-chromatography
#19
Ratchada Auyyuenyong, Andrea Henze, Julia Ungru, Florian J Schweigert, Jens Raila, Ingrid Vervuert
Obesity is a key component of equine metabolic syndrome, which is highly associated with laminitis. Feed restriction and/or exercise are known to alleviate the detrimental effects of insulin resistance in obese ponies. However, little is known about changes in the serum lipid patterns due to weight reduction and its association with disease outcomes. Therefore, the lipid patterns in the serum of 14 mature ponies before and after a 14-week body weight reduction program (BWRP) were investigated by multi-one-dimensional thin-layer chromatography (MOD-TLC)...
November 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29240897/factors-influencing-women-in-physical-activity-programs-in-malaysia
#20
C Hanlon, S Khoo, T Morris, R Eime
The majority of research on factors associated with women participation in physical activity (PA) has been in developed countries with limited research in developing countries. Few women in Malaysia are active at the recommended levels for health, and activity rates are less than developed countries. Little research has focused specially on physically active Malaysian women and the factors that contribute to them becoming and staying active in PA programs. This lack of knowledge hinders the tailored development and implementation of PA programs to meet their needs...
December 11, 2017: Health Promotion International
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