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https://www.readbyqxmd.com/read/29902727/live-attenuated-bivalent-measles-virus-derived-vaccines-targeting-middle-east-respiratory-syndrome-coronavirus-induce-robust-and-multifunctional-t-cell-responses-against-both-viruses-in-an-appropriate-mouse-model
#1
Bianca S Bodmer, Anna H Fiedler, Jan R H Hanauer, Steffen Prüfer, Michael D Mühlebach
Cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to occur, making it one of the WHO´s targets for accelerated vaccine development. One vaccine candidate is based on live-attenuated measles virus (MV) vaccine encoding the MERS-CoV spike glycoprotein (MERS-S). MVvac2 -MERS-S(H) induces robust humoral and cellular immunity against MERS-S mediating protection. Here, the induction and nature of immunity after vaccination with MVvac2 -MERS-S(H) or novel MVvac2 -MERS-N were further characterized...
June 11, 2018: Virology
https://www.readbyqxmd.com/read/29873383/sequencing-of-human-genomes-extracted-from-single-cancer-cells-isolated-in-a-valveless-microfluidic-device
#2
Rodolphe Marie, Marie Pødenphant, Kamila Koprowska, Loic Bærlocher, Roland C M Vulders, Jennifer Wilding, Neil Ashley, Simon J McGowan, Dianne van Strijp, Freek van Hemert, Tom Olesen, Niels Agersnap, Brian Bilenberg, Celine Sabatel, Julien Schira, Anders Kristensen, Walter Bodmer, Pieter J van der Zaag, Kalim U Mir
Sequencing the genomes of individual cells enables the direct determination of genetic heterogeneity amongst cells within a population. We have developed an injection-moulded valveless microfluidic device in which single cells from colorectal cancer derived cell lines (LS174T, LS180 and RKO) and fresh colorectal tumors have been individually trapped, their genomes extracted and prepared for sequencing using multiple displacement amplification (MDA). Ninety nine percent of the DNA sequences obtained mapped to a reference human genome, indicating that there was effectively no contamination of these samples from non-human sources...
June 6, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29768408/a-homozygous-kat2b-variant-modulates-the-clinical-phenotype-of-add3-deficiency-in-humans-and-flies
#3
Sara Gonçalves, Julie Patat, Maria Clara Guida, Noelle Lachaussée, Christelle Arrondel, Martin Helmstädter, Olivia Boyer, Olivier Gribouval, Marie-Claire Gubler, Geraldine Mollet, Marlène Rio, Marina Charbit, Christine Bole-Feysot, Patrick Nitschke, Tobias B Huber, Patricia G Wheeler, Devon Haynes, Jane Juusola, Thierry Billette de Villemeur, Caroline Nava, Alexandra Afenjar, Boris Keren, Rolf Bodmer, Corinne Antignac, Matias Simons
Recent evidence suggests that the presence of more than one pathogenic mutation in a single patient is more common than previously anticipated. One of the challenges hereby is to dissect the contribution of each gene mutation, for which animal models such as Drosophila can provide a valuable aid. Here, we identified three families with mutations in ADD3, encoding for adducin-γ, with intellectual disability, microcephaly, cataracts and skeletal defects. In one of the families with additional cardiomyopathy and steroid-resistant nephrotic syndrome (SRNS), we found a homozygous variant in KAT2B, encoding the lysine acetyltransferase 2B, with impact on KAT2B protein levels in patient fibroblasts, suggesting that this second mutation might contribute to the increased disease spectrum...
May 16, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29767895/-%C3%A2-doctor-i-am-fasting-during-chemotherapy-%C3%A2-illusion-or-new-clinical-facts
#4
Mauro Frigeri, Marica Brnic-Bontognali, Valeria Galetti, Pierre-Yves Dietrich, Alexandre Bodmer
Fasting concomitantly with oncology treatments (chemotherapy mainly) induces a growing interest among patients following overmediatisation of recent discoveries. The goal of this article is to provide updated information about this approach. According to preclinical studies, fasting may be a way to increase the therapeutic index of major oncology treatments. However, clinical data is based on small exploratory studies only and the results of larger scale studies are not yet available. The approach of fasting during chemotherapy can and should neither be recommended nor implemented in standard care...
May 16, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29753483/sanitation-of-staphylococcus-aureus-genotype-b-positive-dairy-herds-a-field-study
#5
C Sartori, R Boss, M Bodmer, A Leuenberger, I Ivanovic, H U Graber
Staphylococcus aureus is one of the most widespread mastitis pathogens infecting dairy cattle worldwide. In Switzerland, different bovine genotypes of Staph. aureus have been identified, and genotype B (GTB) was demonstrated to be a highly contagious subtype, causing herd problems in cattle. As the efficacy of antibiotic therapy against Staph. aureus is not satisfactory, the most promising strategy for controlling this udder pathogen is the implementation of specific sanitation programs for affected farms. The aim of the present longitudinal study was the field evaluation of 2 analytical approaches for the sanitation of Staph...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29730536/differences-in-response-inhibition-processes-between-adolescents-and-adults-are-modulated-by-sensory-processes
#6
Benjamin Bodmer, Julia Friedrich, Veit Roessner, Christian Beste
Response inhibition processes undergo strong developmental changes. The same is true for sensory processes, and recent evidence shows that there also within-modality differences in the efficacy to trigger motor response inhibition. Yet, modulatory effects of within-modality differences during age-related changes in response inhibition between adolescence and adulthood are still indeterminate. We investigated this question in a system neurophysiological approach combining analysis of event-related potentials (ERPs) with temporal EEG signal decomposition and source localization processes...
April 21, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29725037/author-correction-the-irish-dna-atlas-revealing-fine-scale-population-structure-and-history-within-ireland
#7
Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Anne M Molloy, Lawrence C Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J Lawson, James F Wilson, Gianpiero L Cavalleri
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677205/anemia-in-tuberculosis-cases-and-household-controls-from-tanzania-contribution-of-disease-coinfections-and-the-role-of-hepcidin
#8
Jerry Hella, Colin I Cercamondi, Francis Mhimbira, Mohamed Sasamalo, Nicole Stoffel, Marcel Zwahlen, Thomas Bodmer, Sebastien Gagneux, Klaus Reither, Michael B Zimmermann, Lorenz Risch, Lukas Fenner
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat outcomes. We studied the contribution of anemia and the role of the iron regulatory hormone hepcidin among TB patients and household contacts. METHODS: We analyzed serum samples from 102 TB cases and 98 controls without TB, matched by age/sex, for hepcidin, iron, and inflammation parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29617382/measuring-co2-and-ch4-with-a-portable-gas-analyzer-closed-loop-operation-optimization-and-assessment
#9
Jeremy Wilkinson, Christoph Bors, Florian Burgis, Andreas Lorke, Pascal Bodmer
The use of cavity ring-down spectrometer (CRDS) based portable greenhouse gas analyzers (PGAs) in closed-loop configuration to measure small sample volumes (< 1 l) for CH4 and CO2 concentrations is increasing and offers certain advantages over conventional measurement methods in terms of speed as well as the ability to measure directly in field locations. This first systematic assessment of the uncertainties, problems and issues associated with achieving reliable and repeatable measurement with this technique presents the adaptation, measurement range, calibration and maintenance, accuracy and issues of efficient operation, for one example instrument...
2018: PloS One
https://www.readbyqxmd.com/read/29615380/-antibioticscout-ch-decision-support-for-the-prudent-use-of-antimicrobials-application-in-cattle
#10
R Peter, C Müntener, D Demuth, D Heim, F Stucki, M Mevissen, C Gerspach, M Kaske, A Steiner, M Meylan, M Bodmer, G Schüpbach-Regula, M Feldmann, H Naegeli
The administration of antibiotics in livestock has been criticized for many years, in particular because of an inappropriate use and the appearance of antibiotic residues in the environment, which can promote the emergence and spread of resistant bacteria. However, antibiotics are essential for the successful and sustainable control of bacterial pathogens. With the aim of optimizing the use of antibiotics in food animals and minimizing the prevalence of resistant bacteria, AntibioticScout. ch provides a decision aid for the prudent use of antimicrobial drugs...
April 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29556019/high-throughput-sequencing-of-nodal-marginal-zone-lymphomas-identifies-recurrent-braf-mutations
#11
V Pillonel, D Juskevicius, C K Y Ng, A Bodmer, A Zettl, D Jucker, S Dirnhofer, A Tzankov
Nodal marginal zone lymphoma (NMZL) is a rare small B-cell lymphoma lacking disease-defining phenotype and precise diagnostic markers. To better understand the mutational landscape of NMZL, particularly in comparison to other nodal small B-cell lymphomas, we performed whole-exome sequencing, targeted high-throughput sequencing, and array-comparative genomic hybridization on a retrospective series. Our study identified for the first time recurrent, diagnostically useful, and potentially therapeutically relevant BRAF mutations in NMZL...
February 28, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29514098/ceramide-protein-interactions-modulate-ceramide-associated-lipotoxic-cardiomyopathy
#12
Stanley M Walls, Anthony Cammarato, Dale A Chatfield, Karen Ocorr, Greg L Harris, Rolf Bodmer
Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear. Here, we investigated the association of ceramide metabolism and ceramide-interacting proteins (CIPs) in LCM in the Drosophila heart model. We find that ceramide feeding or ceramide-elevating genetic manipulations are strongly associated with cardiac dilation and defects in contractility. High ceramide-associated LCM is prevented by inhibiting ceramide synthesis, establishing a robust model of direct ceramide-associated LCM, corroborating previous indirect evidence in mammals...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29486762/outcomes-and-costs-of-ranibizumab-and-aflibercept-treatment-in-a-health-service-research-context
#13
Martin K Schmid, Oliver Reich, Eva Blozik, Livia Faes, Nicolas S Bodmer, Silvan Locher, Michael A Thiel, Roland Rapold, Maximilian Kuhn, Lucas M Bachmann
BACKGROUND: To compare anti-VEGF treatments for macular disease in terms of costs and clinical outcomes. METHODS: We identified patients suffering from macular disease and treated either with aflibercept, ranibizumab or both at the largest public eye clinic in Switzerland between January 1st and December 31st 2016 who were insured in one of the two participating health insurance companies. Clinical data were extracted from the electronic health record system. The health insurers provided the health claim costs for the ophthalmologic care and the total health care costs of each patient in the observation period...
February 27, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29437009/the-bhlh-protein-nulp1-is-essential-for-femur-development-via-acting-as-a-cofactor-in-wnt-signaling-in-drosophila
#14
Q Zeng, Y Wan, P Zhu, M Zhao, F Jiang, J Chen, M Tang, X Zhu, Y Li, H Zha, Y Wang, M Hu, X Mo, Y Zhang, Y Chen, Y Chen, X Ye, R Bodmer, K Ocorr, Z Jiang, J Zhuang, W Yuan, X Wu
BACKGROUND: The basic helix-loop-helix (bHLH) protein families are a large class of transcription factors, which are associated with cell proliferation, tissue differentiation, and other important development processes. We reported that the Nuclear localized protein-1 (Nulp1) might act as a novel bHLH transcriptional factor to mediate cellular functions. However, its role in development in vivo remains unknown. METHODS: Nulp1 (dNulp1) mutants are generated by CRISPR/Cas9 targeting the Domain of Unknown Function (DUF654) in its C terminal...
March 9, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29435853/do-patients-whose-tumor-achieved-a-pathological-response-relapse-at-specific-sites-a-substudy-of-the-eortc-10994-big-1-00-trial
#15
Kim C Aalders, Nathan Touati, Konstantinos Tryfonidis, Mylène Annonay, Saskia Litiere, Jonas Bergh, Alexandre Bodmer, David A Cameron, Hervé R Bonnefoi
PURPOSE: To determine the sites of first distant relapse in patients with or without pCR following neoadjuvant chemotherapy in breast cancer patients enrolled in the EORTC 10994/BIG-1-00 trial. METHODS: We included patients enrolled in the EORTC 10994/BIG-1-00 trial who received at least one chemotherapy cycle before surgery and who had been diagnosed with a distant relapse. pCR was defined as no evidence of residual invasive cancer in the primary tumor and axillary lymph nodes with or without residual ductal carcinoma in situ...
June 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29433483/control-of-staphylococcus-aureus-in-dairy-herds-in-a-region-with-raw-milk-cheese-production-farmers-attitudes-knowledge-behaviour-and-belief-in-self-efficacy
#16
Marie-Eve Cousin, Maria Christina Härdi-Landerer, Verena Völk, Michèle Bodmer
BACKGROUND: Contagious mastitis is an important disease in dairy cattle, and the causative agent S. aureus can also impair raw milk cheese quality. In a confined region in eastern Switzerland attitude, knowledge and behaviour towards S. aureus und S. aureus control was assessed in 90 dairy farmers with communal alpine pasturing including raw milk cheese production with the aid of a questionnaire. RESULTS: Forty-three out of 90 questionnaires were returned (48% return rate)...
February 13, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29352609/induction-of-mitophagy-in-the-hei-oc1-auditory-cell-line-and-activation-of-the-atg12-lc3-pathway-in-the-organ-of-corti
#17
Cristian Setz, Anne-Sophie Benischke, Anna Catharina Pinho Ferreira Bento, Yves Brand, Soledad Levano, Franziska Paech, Katharina Leitmeyer, Daniel Bodmer
Autophagy is a highly evolutionary conserved quality control defense mechanism within cells, which has also been implicated in cell death processes. In the mammalian inner ear, autophagy has been shown to play a role during early morphogenesis as well as in adult cochlear hair cells exposed to ototoxic insults. Mitophagy, a selective autophagic cell process targeting mitochondria, hasn't been studied in the inner ear so far. On this work, we searched for molecular indicators of mitophagy within House Ear Institute-Organ of Corti-1 (HEI-OC1) cells as well as in the organ of Corti (OC)...
April 2018: Hearing Research
https://www.readbyqxmd.com/read/29329624/apparent-prevalence-of-and-risk-factors-for-infection-with-ostertagia-ostertagi-fasciola-hepatica-and-dictyocaulus-viviparus-in-swiss-dairy-herds
#18
C F Frey, R Eicher, K Raue, C Strube, M Bodmer, B Hentrich, B Gottstein, N Marreros
Infections with helminth parasites can negatively affect performance of dairy cows. Knowledge on infection intensity, spatial distributions and risk factors are key to develop targeted treatment strategies. Canada and most EU countries have conducted large investigations, but respective data for Switzerland were missing. We now performed a bulk tank milk serosurvey for Ostertagia ostertagi, Fasciola hepatica, and Dictyocaulus viviparus on a total of 1036 voluntarily participating dairy herds that were sampled at confinement periods, i...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29315292/phase-i-study-of-sorafenib-combined-with-radiation-therapy-and-temozolomide-as-first-line-treatment-of-high-grade-glioma
#19
A F Hottinger, A Ben Aissa, V Espeli, D Squiban, N Dunkel, M I Vargas, T Hundsberger, N Mach, K Schaller, D C Weber, A Bodmer, P-Y Dietrich
This corrects the article DOI: 10.1038/bjc.2014.209.
March 20, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29301965/genetics-of-the-human-face-identification-of-large-effect-single-gene-variants
#20
Daniel J M Crouch, Bruce Winney, Willem P Koppen, William J Christmas, Katarzyna Hutnik, Tammy Day, Devendra Meena, Abdelhamid Boumertit, Pirro Hysi, Ayrun Nessa, Tim D Spector, Josef Kittler, Walter F Bodmer
To discover specific variants with relatively large effects on the human face, we have devised an approach to identifying facial features with high heritability. This is based on using twin data to estimate the additive genetic value of each point on a face, as provided by a 3D camera system. In addition, we have used the ethnic difference between East Asian and European faces as a further source of face genetic variation. We use principal components (PCs) analysis to provide a fine definition of the surface features of human faces around the eyes and of the profile, and chose upper and lower 10% extremes of the most heritable PCs for looking for genetic associations...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
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