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https://www.readbyqxmd.com/read/29222464/the-irish-dna-atlas-revealing-fine-scale-population-structure-and-history-within-ireland
#1
Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Anne M Molloy, Lawrence C Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J Lawson, James F Wilson, Gianpiero L Cavalleri
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the 'Irish DNA Atlas', a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of 'Gaelic' Irish ancestry, and three of shared Irish-British ancestry...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203786/antigen-specific-oncolytic-mv-based-tumor-vaccines-through-presentation-of-selected-tumor-associated-antigens-on-infected-cells-or-virus-like-particles
#2
Stefan Hutzler, Stephanie Erbar, Robert A Jabulowsky, Jan R H Hanauer, Jürgen H Schnotz, Tim Beissert, Bianca S Bodmer, Regina Eberle, Klaus Boller, Thorsten Klamp, Ugur Sahin, Michael D Mühlebach
Recombinant vaccine strain-derived measles virus (MV) is clinically tested both as vaccine platform to protect against other pathogens and as oncolytic virus for tumor treatment. To investigate the potential synergism in anti-tumoral efficacy of oncolytic and vaccine properties, we chose Ovalbumin and an ideal tumor antigen, claudin-6, for pre-clinical proof of concept. To enhance immunogenicity, both antigens were presented by retroviral virus-like particle produced in situ during MV-infection. All recombinant MV revealed normal growths, genetic stability, and proper expression and presentation of both antigens...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29182629/effects-of-peroxisome-proliferator-activated-receptors-ppar-%C3%AE-and-%C3%AE-agonists-on-cochlear-protection-from-oxidative-stress
#3
Marijana Sekulic-Jablanovic, Vesna Petkovic, Matthew B Wright, Krystsina Kucharava, Nathan Huerzeler, Soledad Levano, Yves Brand, Katharina Leitmeyer, Andrea Glutz, Alexander Bausch, Daniel Bodmer
Various insults cause ototoxicity in mammals by increasing oxidative stress leading to apoptosis of auditory hair cells (HCs). The thiazolidinediones (TZDs; e.g., pioglitazone) and fibrate (e.g., fenofibrate) drugs are used for the treatment of diabetes and dyslipidemia. These agents target the peroxisome proliferator-activated receptors, PPARγ and PPARα, which are transcription factors that influence glucose and lipid metabolism, inflammation, and organ protection. In this study, we explored the effects of pioglitazone and other PPAR agonists to prevent gentamicin-induced oxidative stress and apoptosis in mouse organ of Corti (OC) explants...
2017: PloS One
https://www.readbyqxmd.com/read/29076124/-long-term-outcome-analysis-of-subjective-and-objective-parameters-after-breast-reduction-in-159-cases-patients-judge-differently-from-plastic-surgeons
#4
Rik Osinga, Doris Babst, Elvira S Bodmer, Bjoern C Link, Elmar Fritsche, Urs Hug
Introduction This work assessed both subjective and objective postoperative parameters after breast reduction surgery and compared between patients and plastic surgeons. Patients and Methods After an average postoperative observation period of 6.7 ± 2.7 (2 - 13) years, 159 out of 259 patients (61 %) were examined. The mean age at the time of surgery was 37 ± 14 (15 - 74) years. The postoperative anatomy of the breast and other anthropometric parameters were measured in cm with the patient in an upright position...
October 26, 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29054899/lung-adenocarcinoma-metastastic-lesion-in-the-internal-auditory-meatus
#5
Eugene Hung Chih Wong, Daniel Bodmer, Nora Tetter, Yves Brand
Metastasis to the cerebellopontine angle (CPA) or internal auditory meatus (IAM) is rare.We report a rare case of a 69-year-old woman with metastatic lung adenocarcinoma, who presented with 2 weeks history of left-sided hearing loss and progressively worsening vertigo. Examination revealed a left-sided facial nerve palsy while pure tone audiometry (PTA) showed a new left-sided deafness. MRI showed a new enhancing soft tissue lesion in the left IAM, highly suspicious of new metastases from her progressive lung cancer, which contributed to her neuro-otological symptoms...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29031895/chronic-pelvic-pain-in-an-interdisciplinary-setting-1-year-prospective%C3%A2-cohort
#6
Catherine Allaire, Christina Williams, Sonja Bodmer-Roy, Sean Zhu, Kristina Arion, Kristin Ambacher, Jessica Wu, Ali Yosef, Fontayne Wong, Heather Noga, Susannah Britnell, Holly Yager, Mohamed A Bedaiwy, Arianne Y Albert, Sarka Lisonkova, Paul J Yong
BACKGROUND: Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities. Thus, an interdisciplinary approach has been proposed for chronic pelvic pain, where these multifactorial comorbidities can be addressed by different interventions at a single integrated center. Moreover, while cross-sectional studies can provide some insight into the association between these comorbidities and chronic pelvic pain severity, prospective longitudinal cohorts can identify comorbidities associated with changes in chronic pelvic pain severity over time...
October 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29027197/the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-new-users-of-antiepileptic-drugs
#7
Noel Frey, Michael Bodmer, Andreas Bircher, Stephan Rüegg, Susan S Jick, Christoph R Meier, Julia Spoendlin
OBJECTIVE: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. METHODS: In a matched case-control study of 480 previously validated SJS/TEN cases (1995-2013) we used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs), and calculated absolute risks of SJS/TEN within separate cohorts of new users of 28 AEDs...
October 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28986453/reduced-cardiac-calcineurin-expression-mimics-long-term-hypoxia-induced-heart-defects-in-drosophila
#8
Rachel Zarndt, Stanley M Walls, Karen Ocorr, Rolf Bodmer
BACKGROUND: Hypoxia is often associated with cardiopulmonary diseases, which represent some of the leading causes of mortality worldwide. Long-term hypoxia exposures, whether from disease or environmental condition, can cause cardiomyopathy and lead to heart failure. Indeed, hypoxia-induced heart failure is a hallmark feature of chronic mountain sickness in maladapted populations living at high altitude. In a previously established Drosophila heart model for long-term hypoxia exposure, we found that hypoxia caused heart dysfunction...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28981119/sesn2-ampk-mtor-signaling-mediates-balance-between-survival-and-apoptosis-in-sensory-hair-cells-under-stress
#9
Daniel Bodmer, Soledad Levano-Huaman
No abstract text is available yet for this article.
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28939722/protocol-ii-versus-protocol-iii-given-twice-during-reinduction-therapy-in-children-with-medium-risk-all
#10
Franco Locatelli, Maria Grazia Valsecchi, Anja Möricke, Martin Zimmermann, Bernd Gruhn, Andrea Biondi, Andreas E Kulozik, Daniela Silvestri, Nicole Bodmer, Maria Caterina Putti, Stefan Burdach, Concetta Micalizzi, Andrea Teigler-Schlegel, Jörg Ritter, Andrea Pession, Gunnar Cario, Stefan Bielack, Giuseppe Basso, Thomas Klingebiel, Luciana Vinti, Carmelo Rizzari, Andishe Attarbaschi, Nicola Santoro, Rosanna Parasole, Georg Mann, Leonid Karawajew, Oskar A Haas, Valentino Conter, Martin Schrappe
No abstract text is available yet for this article.
September 22, 2017: Blood
https://www.readbyqxmd.com/read/28930984/high-fat-diet-feeding-and-high-throughput-triacylglyceride-assay-in-drosophila-melanogaster
#11
Soda Balla Diop, Ryan T Birse, Rolf Bodmer
Heart disease is the number one cause of human death worldwide. Numerous studies have shown strong connections between obesity and cardiac malfunction in humans, but more tools and research efforts are needed to better elucidate the mechanisms involved. For over a century, the genetically highly tractable model of Drosophila has been instrumental in the discovery of key genes and molecular pathways that proved to be highly conserved across species. Many biological processes and disease mechanisms are functionally conserved in the fly, such as development (e...
September 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28889125/brimonidine-protects-auditory-hair-cells-from-in-vitro-induced-toxicity-of-gentamicin
#12
Maurizio Cortada, Soledad Levano, Daniel Bodmer
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28875750/muskelschmerzen-ikterus-und-akutes-nierenversagen
#13
Daniel Gerosa, Adrian Walder, Beat Schwegler, Katja Eigenmann, Michael Bodmer
No abstract text is available yet for this article.
September 2017: Praxis
https://www.readbyqxmd.com/read/28838250/an-update-on-drug-design-strategies-to-prevent-acquired-sensorineural-hearing-loss
#14
REVIEW
Daniel Bodmer
Acute sensorineural hearing loss is a dramatic event for the patient. Different pathologies might result in acute sensorineural hearing loss, such as sudden hearing loss, exposure to medications/drugs or loud sound. Current therapeutic approaches include steroids and hyperbaric oxygen in addition to other methods. Research activities of the past have shed light on the molecular mechanisms involved in damage to hair cells, the synapses at the hair cell spiral ganglion junction and the stria vascularis. Molecular events and signaling pathways which underlie damage to these structures have been discovered...
November 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28766738/major-shifts-in-amazon-wildlife-populations-from-recent-climatic-intensification
#15
Richard Bodmer, Pedro Mayor, Miguel Antunez, Kimberlyn Chota, Tula Fang, Pablo Puertas, Marlini Pittet, Maire Kirkland, Mike Walkey, Claudia Rios, Pedro Perez-Peña, Peter Henderson, William Bodmer, Andy Bicerra, Joseph Zegarra, Emma Docherty
In the western Amazon basin, recent intensification of river level cycles has increased flooding during the wet seasons and decreased precipitation during the dry season. Greater than normal floods occurred in 2009 and in all years from 2011-2015 during high water seasons, and a drought occurred during the 2010 low water season. During these years, we surveyed populations of terrestrial, arboreal and aquatic wildlife in a seasonally flooded Amazonian forest to study the consequences of intensification of climatic fluctuations to wildlife populations and in turn resource use by traditional people...
August 2, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#16
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28692587/colorectal-cancer-and-markers-of-anemia
#17
Cornelia Schneider, Michael Bodmer, Susan S Jick, Christoph R Meier
Unexplained iron-deficiency anemia is an important marker for colorectal cancer (CRC). Our objectives were as follows: (a) to assess whether the association between anemia and CRC can be detected on the 'Clinical Practice Research Datalink', (b) to evaluate the timing between laboratory changes and CRC detection, and (c) to analyze its association with survival. We conducted a case-control study on patients with an incident CRC diagnosis during 2008-2012 and a 1 : 1-matched control group. We compared anemia markers serum ferritin (SF), hemoglobin (Hb), mean corpuscular volume (MCV), and red blood cell count between cases and controls using conditional logistic regression...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28688178/transcriptomic-analysis-identifies-a-role-of-pi3k-akt-signalling-in-the-responses-of-skeletal-muscle-to-acute-hypoxia-in-vivo
#18
Zhuohui Gan, Frank L Powell, Alexander C Zambon, Kyle S Buchholz, Zhenxing Fu, Karen Ocorr, Rolf Bodmer, Esteban A Moya, Jennifer C Stowe, Gabriel G Haddad, Andrew D McCulloch
KEY POINTS: Changes in gene expression that occur within hours of exposure to hypoxia in in vivo skeletal muscles remain unexplored. Two hours of hypoxia caused significant down-regulation of extracellular matrix genes followed by a shift at 6 h to altered expression of genes associated with the nuclear lumen while respiratory and blood gases were stabilized. Enrichment analysis of mRNAs classified by stability rates suggests an attenuation of post-transcriptional regulation within hours of hypoxic exposure, where PI3K-Akt signalling was suggested to have a nodal role by pathway analysis...
September 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28596490/a-genetic-polymorphism-repurposes-the-g-protein-coupled-and-membrane-associated-estrogen-receptor-gper-to-a-transcription-factor-like-molecule-promoting-paracrine-signaling-between-stroma-and-breast-carcinoma-cells
#19
Marco Pupo, Alexandre Bodmer, Melissa Berto, Marcello Maggiolini, Pierre-Yves Dietrich, Didier Picard
GPER is a membrane-associated estrogen receptor of the family of G-protein coupled receptors. For breast cancer, the contribution of GPER to promoting the proliferation and migration of both carcinoma cells and cancer-associated fibroblasts (CAFs) in response to estrogen and other agonists has extensively been investigated. Intriguingly, GPER was previously found to be localized to the nucleus in one isolate of breast CAFs. Moreover, this nuclear GPER was shown to bind regulatory sequences of cancer-relevant target genes and to induce their expression...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28580173/sesn2-gene-ablation-enhances-susceptibility-to-gentamicin-induced-hair-cell-death-via-modulation-of-ampk-mtor-signaling
#20
Eliane Ebnoether, Alessia Ramseier, Maurizio Cortada, Daniel Bodmer, Soledad Levano-Huaman
The process of gentamicin-induced hair cell damage includes the activation of oxidative stress processes. Sestrins, as stress-responsive proteins, protect cells against oxidative stress. Sestrins, particularly Sestrin-2, suppress excessive reactive oxygen species (ROS) accumulation and inhibit mammalian target of rapamycin complex 1 (mTORC1). Thus, we addressed the role of Sestrin-2 in the regulation of sensory hair cell survival after gentamicin exposure. Here, we show that Sestrins were expressed in the inner ear tissues, and Sestrin-2 immunolocalized in sensory hair cells and spiral ganglion (SG)...
2017: Cell Death Discovery
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