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https://www.readbyqxmd.com/read/27917537/reproductive-biology-for-the-assessment-of-hunting-sustainability-of-rainforest-mammal-populations-through-the-participation-of-local-communities
#1
Pedro Mayor, Hani El Bizri, Richard E Bodmer, Mark Bowler
Wildlife subsistence hunting is a major source of protein for tropical rural populations and a prominent conservation issue. The intrinsic rate of natural increase (rmax ) of populations is a key reproductive parameter in the most-used assessments of hunting sustainability. However, since researchers face severe difficulties in obtaining reproductive data in the wild, these assessments often use 'classic' reproductive rates calculated mostly from captive studies conducted 30 years ago, resulting in flaws in almost 50% of studies and hampering decision-makings on wildlife management...
December 5, 2016: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/27890338/a-longitudinal-study-on-transmission-of-staphylococcus-aureus-genotype-b-in-swiss-communal-dairy-herds
#2
Bart H P van den Borne, Hans U Graber, Verena Voelk, Carlotta Sartori, Adrian Steiner, M Christina Haerdi-Landerer, Michèle Bodmer
Staphylococcus aureus is a common mastitis causing pathogen of dairy cattle. Several S. aureus genotypes exist, of which genotype B (GTB) is highly prevalent in Swiss dairy herds. Dairy farming in mountainous regions of Switzerland is characterised by the movement of dairy cattle to communal pasture-based operations at higher altitudes. Cows from different herds of origin share pastures and milking equipment for a period of 2 to 3 months during summer. The aim of this longitudinal observational study was to quantify transmission of S...
November 18, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27868282/validation-of-stevens-johnson-syndrome-or-toxic-epidermal-necrolysis-diagnoses-in-the-clinical-practice-research-datalink
#3
Noel Frey, Andreas Bircher, Michael Bodmer, Susan S Jick, Christoph R Meier, Julia Spoendlin
PURPOSE: To evaluate the validity of recorded diagnoses of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in the Clinical Practice Research Datalink (CPRD). METHODS: We identified patients with a diagnosis of SJS or TEN between 1995 and 2013 in the CPRD. We reviewed information from patient records, free text, and hospital episode statistics (HES) data, and excluded patients with no indication of a secondary care referral. Remaining patients were classified as probable, possible, or unlikely cases of SJS/TEN by two specialised clinicians or based on pre-defined classification criteria...
November 20, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27862250/prenatal-myelomeningocele-repair-do-bladders-better
#4
Maya Horst, Luca Mazzone, Thomas Schraner, Christine Bodmer, Ueli Möhrlen, Martin Meuli, Rita Gobet
AIMS: Prenatal myelomeningocele (MMC) repair has been proven to significantly reduce the need for hydrocephalus shunting and improve lower-extremity motor outcomes. The aim of this study was to evaluate the effect of prenatal MMC repair on the urological outcome. METHODS: All patients who underwent fetal MMC repair at our institution are followed prospectively. Assessments include medical history, renal and bladder ultrasound, voiding cystourethrogram and urodynamic study, need for clean intermittent catheterization (CIC) and anticholinergics, and the occurrence of urinary tract infections (UTI)...
November 15, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27793636/extracellular-matrix-downregulation-in-the-drosophila-heart-preserves-contractile-function-and-improves-lifespan
#5
Ayla O Sessions, Gaurav Kaushik, Sarah Parker, Koen Raedschelders, Rolf Bodmer, Jennifer E Van Eyk, Adam J Engler
Aging is associated with extensive remodeling of the heart, including basement membrane (BM) components that surround cardiomyocytes. Remodeling is thought to impair cardiac mechanotransduction, but the contribution of specific BM components to age-related lateral communication between cardiomyocytes is unclear. Using a genetically tractable, rapidly aging model with sufficient cardiac genetic homology and morphology, e.g. Drosophila melanogaster, we observed differential regulation of BM collagens between laboratory strains, correlating with changes in muscle physiology leading to cardiac dysfunction...
October 25, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27787949/pasireotide-prevents-nuclear-factor-of-activated-t-cells-nuclear-translocation-and-acts-as-a-protective-agent-in-aminoglycoside-induced-auditory-hair-cell-loss
#6
Daniel Bodmer, Adrijana Perkovic, Marijana Sekulic-Jablanovic, Matthew B Wright, Vesna Petkovic
Hearing impairment is a global health problem with a high socioeconomic impact. Damage to auditory hair cells (HCs) in the inner ear as a result of aging, disease, trauma, or toxicity, underlies the majority of cases of sensorineural hearing loss. Previously we demonstrated that the Ca(2+) -sensitive neuropeptide, somatostatin (SST), and an analog, octreotide, protect HCs from gentamicin-induced cell death in vitro. Aminoglycosides such as gentamicin trigger a calcium ion influx (Ca(2+) ) that activates pro-apoptotic signaling cascades in HCs...
October 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27696829/deconstructing-methane-emissions-from-a-small-northern-european-river-hydrodynamics-and-temperature-as-key-drivers
#7
Daniel F McGinnis, Nicole Bilsley, Mark Schmidt, Peer Fietzek, Pascal Bodmer, Katrin Premke, Andreas Lorke, Sabine Flury
Methane (CH4) emissions from small rivers and streams, particularly via ebullition, are currently under-represented in the literature. Here, we quantify the methane effluxes and drivers in a small, Northern European river. Methane fluxes are comparable to those from tropical aquatic systems, with average emissions of 320 mg CH4 m-2 d-1. Two important drivers of methane flux variations were identified in the studied system: 1) temperature-driven sediment methane ebullition and 2) flow-dependent contribution suspected to be hydraulic exchange with adjacent wetlands and small side-bays...
October 3, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27659466/52-genetic-loci-influencing-myocardial%C3%A2-mass
#8
Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, Lude Franke, Matthew T Maurano, Xinchen Wang, Irene Mateo Leach, Mark Eijgelsheim, Nona Sotoodehnia, Caroline Hayward, Rossella Sorice, Osorio Meirelles, Leo-Pekka Lyytikäinen, Ozren Polašek, Toshiko Tanaka, Dan E Arking, Sheila Ulivi, Stella Trompet, Martina Müller-Nurasyid, Albert V Smith, Marcus Dörr, Kathleen F Kerr, Jared W Magnani, Fabiola Del Greco M, Weihua Zhang, Ilja M Nolte, Claudia T Silva, Sandosh Padmanabhan, Vinicius Tragante, Tõnu Esko, Gonçalo R Abecasis, Michiel E Adriaens, Karl Andersen, Phil Barnett, Joshua C Bis, Rolf Bodmer, Brendan M Buckley, Harry Campbell, Megan V Cannon, Aravinda Chakravarti, Lin Y Chen, Alessandro Delitala, Richard B Devereux, Pieter A Doevendans, Anna F Dominiczak, Luigi Ferrucci, Ian Ford, Christian Gieger, Tamara B Harris, Eric Haugen, Matthias Heinig, Dena G Hernandez, Hans L Hillege, Joel N Hirschhorn, Albert Hofman, Norbert Hubner, Shih-Jen Hwang, Annamaria Iorio, Mika Kähönen, Manolis Kellis, Ivana Kolcic, Ishminder K Kooner, Jaspal S Kooner, Jan A Kors, Edward G Lakatta, Kasper Lage, Lenore J Launer, Daniel Levy, Alicia Lundby, Peter W Macfarlane, Dalit May, Thomas Meitinger, Andres Metspalu, Stefania Nappo, Silvia Naitza, Shane Neph, Alex S Nord, Teresa Nutile, Peter M Okin, Jesper V Olsen, Ben A Oostra, Josef M Penninger, Len A Pennacchio, Tune H Pers, Siegfried Perz, Annette Peters, Yigal M Pinto, Arne Pfeufer, Maria Grazia Pilia, Peter P Pramstaller, Bram P Prins, Olli T Raitakari, Soumya Raychaudhuri, Ken M Rice, Elizabeth J Rossin, Jerome I Rotter, Sebastian Schafer, David Schlessinger, Carsten O Schmidt, Jobanpreet Sehmi, Herman H W Silljé, Gianfranco Sinagra, Moritz F Sinner, Kamil Slowikowski, Elsayed Z Soliman, Timothy D Spector, Wilko Spiering, John A Stamatoyannopoulos, Ronald P Stolk, Konstantin Strauch, Sian-Tsung Tan, Kirill V Tarasov, Bosco Trinh, Andre G Uitterlinden, Malou van den Boogaard, Cornelia M van Duijn, Wiek H van Gilst, Jorma S Viikari, Peter M Visscher, Veronique Vitart, Uwe Völker, Melanie Waldenberger, Christian X Weichenberger, Harm-Jan Westra, Cisca Wijmenga, Bruce H Wolffenbuttel, Jian Yang, Connie R Bezzina, Patricia B Munroe, Harold Snieder, Alan F Wright, Igor Rudan, Laurie A Boyer, Folkert W Asselbergs, Dirk J van Veldhuisen, Bruno H Stricker, Bruce M Psaty, Marina Ciullo, Serena Sanna, Terho Lehtimäki, James F Wilson, Stefania Bandinelli, Alvaro Alonso, Paolo Gasparini, J Wouter Jukema, Stefan Kääb, Vilmundur Gudnason, Stephan B Felix, Susan R Heckbert, Rudolf A de Boer, Christopher Newton-Cheh, Andrew A Hicks, John C Chambers, Yalda Jamshidi, Axel Visel, Vincent M Christoffels, Aaron Isaacs, Nilesh J Samani, Paul I W de Bakker
BACKGROUND: Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death. OBJECTIVES: This meta-analysis sought to gain insights into the genetic determinants of myocardial mass...
September 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27543333/stromal-uptake-and-transmission-of-acid-is-a-pathway-for-venting-cancer-cell-generated-acid
#9
Alzbeta Hulikova, Nicholas Black, Lin-Ting Hsia, Jennifer Wilding, Walter F Bodmer, Pawel Swietach
Proliferation and invasion of cancer cells require favorable pH, yet potentially toxic quantities of acid are produced metabolically. Membrane-bound transporters extrude acid from cancer cells, but little is known about the mechanisms that handle acid once it is released into the poorly perfused extracellular space. Here, we studied acid handling by myofibroblasts (colon cancer-derived Hs675.T, intestinal InMyoFib, embryonic colon-derived CCD-112-CoN), skin fibroblasts (NHDF-Ad), and colorectal cancer (CRC) cells (HCT116, HT29) grown in monoculture or coculture...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27493451/inflammation-thread-runs-across-medical-laboratory-specialities
#10
REVIEW
Urs Nydegger, Thomas Lung, Lorenz Risch, Martin Risch, Pedro Medina Escobar, Thomas Bodmer
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27317320/the-influence-of-the-rearing-period-on-intramammary-infections-in-swiss-dairy-heifers-a-cross-sectional-study
#11
M J Bludau, A Maeschli, F Leiber, P Klocke, J A Berezowski, M Bodmer, B Vidondo
Healthy replacement heifers are one of the foundations of a healthy dairy herd. Farm management and rearing systems in Switzerland provide a wide variety of factors that could potentially be associated with intramammary infections (IMI) in early lactating dairy heifers. In this study, IMI with minor mastitis pathogens such as coagulase-negative staphylococci (CNS), contagious pathogens, and environmental major pathogens were identified. Fifty-four dairy farms were enrolled in the study. A questionnaire was used to collect herd level data on housing, management and welfare of young stock during farm visits and interviews with the farmers...
July 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27307458/evaluation-of-a-multiplex-real-time-pcr-assay-for-detecting-major-bacterial-enteric-pathogens-in-fecal-specimens-intestinal-inflammation-and-bacterial-load-are-correlated-in-campylobacter-infections
#12
Nadia Wohlwend, Sacha Tiermann, Lorenz Risch, Martin Risch, Thomas Bodmer
A total of 1,056 native or Cary-Blair-preserved stool specimens were simultaneously tested by conventional stool culturing and by enteric bacterial panel (EBP) multiplex real-time PCR for Campylobacter jejuni, Campylobacter coli, Salmonella spp., and shigellosis disease-causing agents (Shigella spp. and enteroinvasive Escherichia coli [EIEC]). Overall, 143 (13.5%) specimens tested positive by PCR for the targets named above; 3 coinfections and 109 (10.4%) Campylobacter spp., 17 (1.6%) Salmonella spp., and 20 (1...
September 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27147064/lifestyle-factors-psychiatric-and-neurologic-comorbidities-and-drug-use-associated-with-incident-seizures-among-adult-patients-with-depression-a-population-based-nested-case-control-study
#13
Marlene Bloechliger, Alessandro Ceschi, Stephan Rüegg, Susan Sara Jick, Christoph Rudolf Meier, Michael Bodmer
To investigate risk factors for incident seizures among adult patients with depression. We conducted a nested case-control analysis in adult patients with newly diagnosed depression, using data from the U.K.-based Clinical Practice Research Datalink. Among cases with incident seizures and matched controls, we estimated odds ratios (ORs) with 95 % confidence intervals (CIs) of potential risk factors for seizures as reported from data of the general population: underweight (body mass index <18.5 kg/m(2)), smoking, alcoholism, drug abuse, psychiatric or neurologic comorbidities, and concomitant use of drugs...
May 4, 2016: European Journal of Epidemiology
https://www.readbyqxmd.com/read/27132641/-conservative-and-surgical-rehabilitation-of-hearing-loss
#14
REVIEW
Christof Stieger, Daniel Bodmer, Yves Brand
According to WHO 360 million people are hard of hearing. Hearing disorders are not only seen in elderly but also in children. Clinically we differentiate between hearing disorders concerning the transmission of sound from the outer ear to the cochlea (conductive hearing loss) and disorders with reduced sound perception concerning the inner ear an related structures (sensorineural hearing loss). This article summarizes common surgical and technical possibilities for rehabilitation. For each pathology we graphically illustrate the generic working principle of the rehabilitation including the indication range in an exemplary audiogram...
2016: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/27116528/can-low-dose-radiation-therapy-2%C3%A2-%C3%A3-%C3%A2-2%C3%A2-gy-be-used-in-primary-bilateral-conjunctival-follicular-lymphoma
#15
S Cotting-Bodmer, A Moulin, C P Herbort, N Ketterer, M Betz, A Pica, A Schalenbourg
No abstract text is available yet for this article.
April 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27107639/a-restrictive-cardiomyopathy-mutation-in-an-invariant-proline-at-the-myosin-head-rod-junction-enhances-head-flexibility-and-function-yielding-muscle-defects-in-drosophila
#16
Madhulika Achal, Adriana S Trujillo, Girish C Melkani, Gerrie P Farman, Karen Ocorr, Meera C Viswanathan, Gaurav Kaushik, Christopher S Newhard, Bernadette M Glasheen, Anju Melkani, Jennifer A Suggs, Jeffrey R Moore, Douglas M Swank, Rolf Bodmer, Anthony Cammarato, Sanford I Bernstein
An "invariant proline" separates the myosin S1 head from its S2 tail and is proposed to be critical for orienting S1 during its interaction with actin, a process that leads to muscle contraction. Mutation of the invariant proline to leucine (P838L) caused dominant restrictive cardiomyopathy in a pediatric patient (Karam et al., Congenit. Heart Dis. 3:138-43, 2008). Here, we use Drosophila melanogaster to model this mutation and dissect its effects on the biochemical and biophysical properties of myosin, as well as on the structure and physiology of skeletal and cardiac muscles...
June 5, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27101942/paul-ichiro-terasaki-1929-2016-inventor-of-the-microcytotoxicity-assay-and-pioneer-tissue-typer
#17
Walter F Bodmer
No abstract text is available yet for this article.
May 2016: HLA
https://www.readbyqxmd.com/read/27076142/design-and-purification-of-subunit-vaccines-for-prevention-of-clostridium-difficile-infection
#18
Jerzy Karczewski, Jean-Luc Bodmer, James C Cook, Rachel F Xoconostle, Debbie D Nahas, Joseph G Joyce, Jon H Heinrichs, Susan Secore
Clostridium difficile is a gram-positive bacterium responsible for a large proportion of nosocomial infections in the developed world. C. difficile secretes toxins A and B (TcdA and TcdB) and both toxins act synergistically to induce a spectrum of pathological responses in infected individuals ranging from pseudomembranous colitis to C. difficile-associated diarrhea. Toxins A and B have been actively investigated as components of prophylactic vaccine as well as targets for therapeutic intervention with antibodies...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27060357/expression-of-classical-hla-class-i-molecules-regulation-and-clinical-impacts-julia-bodmer-award-review-2015
#19
REVIEW
C René, C Lozano, J-F Eliaou
Human leukocyte antigen (HLA) class I genes are ubiquitously expressed, but in a tissue specific-manner. Their expression is primarily regulated at the transcriptional level and can be modulated both positively and negatively by different stimuli. Advances in sequencing technologies led to the identification of new regulatory variants located in the untranslated regions (UTRs), which could influence the expression. After a brief description of the mechanisms underlying the transcriptional regulation of HLA class I genes expression, we will review how the expression levels of HLA class I genes could affect biological and pathological processes...
May 2016: HLA
https://www.readbyqxmd.com/read/27051663/simvastatin-results-in-a-dose-dependent-toxic-effect-on-spiral-ganglion-neurons-in-an-in-vitro-organotypic-culture-assay
#20
Katharina Leitmeyer, Andrea Glutz, Cristian Setz, Leonie Wieland, Sulamith Egloff, Daniel Bodmer, Yves Brand
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme necessary for the production of mevalonate. They are widely used as cholesterol-lowering drugs. However, conflicting data about the effect of statins on neuronal cells has been published. To explore the effect of simvastatin on spiral ganglion neurons (SGNs), SG explants of 5-day-old rats were treated with increasing concentrations of simvastatin. In addition, SG explants were treated with mevalonate and with the combination of simvastatin and mevalonate...
2016: BioMed Research International
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