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https://www.readbyqxmd.com/read/29031895/chronic-pelvic-pain-in-an-interdisciplinary-setting-1-year-prospective-cohort
#1
Catherine Allaire, Christina Williams, Sonja Bodmer-Roy, Sean Zhu, Kristina Arion, Kristin Ambacher, Jessica Wu, Ali Yosef, Fontayne Wong, Heather Noga, Susannah Britnell, Holly Yager, Mohamed A Bedaiwy, Arianne Y Albert, Sarka Lisonkova, Paul J Yong
BACKGROUND: Chronic pelvic pain affects ∼15% of women, and presents a challenging problem for gynecologists due to its complex etiology involving multiple comorbidities. Thus an interdisciplinary approach has been proposed for chronic pelvic pain, where these multifactorial comorbidities can be addressed by different interventions at a single integrated center. Moreover, while cross-sectional studies can provide some insight into the association between these comorbidities and chronic pelvic pain severity, prospective longitudinal cohorts can identify comorbidities that are associated with changes in chronic pelvic pain severity over time...
October 11, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29027197/the-risk-of-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-in-new-users-of-antiepileptic-drugs
#2
Noel Frey, Michael Bodmer, Andreas Bircher, Stephan Rüegg, Susan S Jick, Christoph R Meier, Julia Spoendlin
OBJECTIVE: Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom. METHODS: In a matched case-control study of 480 previously validated SJS/TEN cases (1995-2013) we used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs), and calculated absolute risks of SJS/TEN within separate cohorts of new users of 28 AEDs...
October 13, 2017: Epilepsia
https://www.readbyqxmd.com/read/28986453/reduced-cardiac-calcineurin-expression-mimics-long-term-hypoxia-induced-heart-defects-in-drosophila
#3
Rachel Zarndt, Stanley M Walls, Karen Ocorr, Rolf Bodmer
BACKGROUND: Hypoxia is often associated with cardiopulmonary diseases, which represent some of the leading causes of mortality worldwide. Long-term hypoxia exposures, whether from disease or environmental condition, can cause cardiomyopathy and lead to heart failure. Indeed, hypoxia-induced heart failure is a hallmark feature of chronic mountain sickness in maladapted populations living at high altitude. In a previously established Drosophila heart model for long-term hypoxia exposure, we found that hypoxia caused heart dysfunction...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28981119/sesn2-ampk-mtor-signaling-mediates-balance-between-survival-and-apoptosis-in-sensory-hair-cells-under-stress
#4
Daniel Bodmer, Soledad Levano-Huaman
No abstract text is available yet for this article.
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28939722/protocol-ii-versus-protocol-iii-given-twice-during-reinduction-therapy-in-children-with-medium-risk-all
#5
Franco Locatelli, Maria Grazia Valsecchi, Anja Möricke, Martin Zimmermann, Bernd Gruhn, Andrea Biondi, Andreas E Kulozik, Daniela Silvestri, Nicole Bodmer, Maria Caterina Putti, Stefan Burdach, Concetta Micalizzi, Andrea Teigler-Schlegel, Jörg Ritter, Andrea Pession, Gunnar Cario, Stefan Bielack, Giuseppe Basso, Thomas Klingebiel, Luciana Vinti, Carmelo Rizzari, Andishe Attarbaschi, Nicola Santoro, Rosanna Parasole, Georg Mann, Leonid Karawajew, Oskar A Haas, Valentino Conter, Martin Schrappe
No abstract text is available yet for this article.
September 22, 2017: Blood
https://www.readbyqxmd.com/read/28930984/high-fat-diet-feeding-and-high-throughput-triacylglyceride-assay-in-drosophila-melanogaster
#6
Soda Balla Diop, Ryan T Birse, Rolf Bodmer
Heart disease is the number one cause of human death worldwide. Numerous studies have shown strong connections between obesity and cardiac malfunction in humans, but more tools and research efforts are needed to better elucidate the mechanisms involved. For over a century, the genetically highly tractable model of Drosophila has been instrumental in the discovery of key genes and molecular pathways that proved to be highly conserved across species. Many biological processes and disease mechanisms are functionally conserved in the fly, such as development (e...
September 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28889125/brimonidine-protects-auditory-hair-cells-from-in-vitro-induced-toxicity-of-gentamicin
#7
Maurizio Cortada, Soledad Levano, Daniel Bodmer
Brimonidine, an alpha-2 adrenergic receptor (α2-AR) agonist, has neuroprotective effects in the visual system and in spiral ganglion neurons. Auditory hair cells (HCs) express all 3 α2-AR subtypes, but their roles in HCs remain unknown. This study investigated the effects of brimonidine on auditory HCs that were also exposed to gentamicin, which is toxic to HCs. Organ of Corti explants were exposed to gentamicin in the presence or absence of brimonidine, and the α2-AR protein expression levels and Erk1/2 and Akt phosphorylation levels were determined...
September 9, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28875750/muskelschmerzen-ikterus-und-akutes-nierenversagen
#8
Daniel Gerosa, Adrian Walder, Beat Schwegler, Katja Eigenmann, Michael Bodmer
No abstract text is available yet for this article.
September 2017: Praxis
https://www.readbyqxmd.com/read/28838250/an-update-on-drug-design-strategies-to-prevent-acquired-sensorineural-hearing-loss
#9
Daniel Bodmer
Acute sensorineural hearing loss is a dramatic event for the patient. Different pathologies might result in acute sensorineural hearing loss, such as sudden hearing loss, exposure to medications/drugs or loud sound. Current therapeutic approaches include steroids and hyperbaric oxygen in addition to other methods. Research activities of the past have shed light on the molecular mechanisms involved in damage to hair cells, the synapses at the hair cell spiral ganglion junction and the stria vascularis. Molecular events and signaling pathways which underlie damage to these structures have been discovered...
August 30, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28766738/major-shifts-in-amazon-wildlife-populations-from-recent-climatic-intensification
#10
Richard Bodmer, Pedro Mayor, Miguel Antunez, Kimberlyn Chota, Tula Fang, Pablo Puertas, Marlini Pittet, Maire Kirkland, Mike Walkey, Claudia Rios, Pedro Perez-Peña, Peter Henderson, William Bodmer, Andy Bicerra, Joseph Zegarra, Emma Docherty
In the western Amazon basin, recent intensification of river level cycles has increased flooding during the wet seasons and decreased precipitation during the dry season. Greater than normal floods occurred in 2009 and in all years from 2011-2015 during high water seasons, and a drought occurred during the 2010 low water season. During these years, we surveyed populations of terrestrial, arboreal and aquatic wildlife in a seasonally flooded Amazonian forest to study the consequences of intensification of climatic fluctuations to wildlife populations and in turn resource use by traditional people...
August 2, 2017: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/28723686/population-based-study-on-the-epidemiology-of-m%C3%A3-ni%C3%A3-re-s-disease
#11
Saskia G Bruderer, Daniel Bodmer, Nadja A Stohler, Susan S Jick, Christoph R Meier
BACKGROUND AND OBJECTIVE: Ménière's disease (MD) is a disorder of the inner ear typically showing recurrent acute episodes of vertigo, hearing loss, and tinnitus. Epidemiologic studies on MD are scarce. We assessed the incidence rates (IRs) of MD and describe the characteristics of MD cases, comparing them to control patients without recorded evidence of MD. STUDY DESIGN: We conducted a retrospective population-based follow-up study and a nested case-control analysis using data from the UK-based Clinical Practice Research Datalink...
2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28692587/colorectal-cancer-and-markers-of-anemia
#12
Cornelia Schneider, Michael Bodmer, Susan S Jick, Christoph R Meier
Unexplained iron-deficiency anemia is an important marker for colorectal cancer (CRC). Our objectives were as follows: (a) to assess whether the association between anemia and CRC can be detected on the 'Clinical Practice Research Datalink', (b) to evaluate the timing between laboratory changes and CRC detection, and (c) to analyze its association with survival. We conducted a case-control study on patients with an incident CRC diagnosis during 2008-2012 and a 1 : 1-matched control group. We compared anemia markers serum ferritin (SF), hemoglobin (Hb), mean corpuscular volume (MCV), and red blood cell count between cases and controls using conditional logistic regression...
July 7, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28688178/transcriptomic-analysis-identifies-a-role-of-pi3k-akt-signalling-in-the-responses-of-skeletal-muscle-to-acute-hypoxia-in-vivo
#13
Zhuohui Gan, Frank L Powell, Alexander C Zambon, Kyle S Buchholz, Zhenxing Fu, Karen Ocorr, Rolf Bodmer, Esteban A Moya, Jennifer C Stowe, Gabriel G Haddad, Andrew D McCulloch
KEY POINTS: Changes in gene expression that occur within hours of exposure to hypoxia in in vivo skeletal muscles remain unexplored. Two hours of hypoxia caused significant down-regulation of extracellular matrix genes followed by a shift at 6 h to altered expression of genes associated with the nuclear lumen while respiratory and blood gases were stabilized. Enrichment analysis of mRNAs classified by stability rates suggests an attenuation of post-transcriptional regulation within hours of hypoxic exposure, where PI3K-Akt signalling was suggested to have a nodal role by pathway analysis...
September 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28596490/a-genetic-polymorphism-repurposes-the-g-protein-coupled-and-membrane-associated-estrogen-receptor-gper-to-a-transcription-factor-like-molecule-promoting-paracrine-signaling-between-stroma-and-breast-carcinoma-cells
#14
Marco Pupo, Alexandre Bodmer, Melissa Berto, Marcello Maggiolini, Pierre-Yves Dietrich, Didier Picard
GPER is a membrane-associated estrogen receptor of the family of G-protein coupled receptors. For breast cancer, the contribution of GPER to promoting the proliferation and migration of both carcinoma cells and cancer-associated fibroblasts (CAFs) in response to estrogen and other agonists has extensively been investigated. Intriguingly, GPER was previously found to be localized to the nucleus in one isolate of breast CAFs. Moreover, this nuclear GPER was shown to bind regulatory sequences of cancer-relevant target genes and to induce their expression...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28580173/sesn2-gene-ablation-enhances-susceptibility-to-gentamicin-induced-hair-cell-death-via-modulation-of-ampk-mtor-signaling
#15
Eliane Ebnoether, Alessia Ramseier, Maurizio Cortada, Daniel Bodmer, Soledad Levano-Huaman
The process of gentamicin-induced hair cell damage includes the activation of oxidative stress processes. Sestrins, as stress-responsive proteins, protect cells against oxidative stress. Sestrins, particularly Sestrin-2, suppress excessive reactive oxygen species (ROS) accumulation and inhibit mammalian target of rapamycin complex 1 (mTORC1). Thus, we addressed the role of Sestrin-2 in the regulation of sensory hair cell survival after gentamicin exposure. Here, we show that Sestrins were expressed in the inner ear tissues, and Sestrin-2 immunolocalized in sensory hair cells and spiral ganglion (SG)...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28540114/expert-consensus-on-predictive-parameters-for-the-occurrence-of-a-fall-and-a-contralateral-hip-fracture-1-and-3-years-after-hip-fracture-a-delphi-survey
#16
Alexander Joeris, Anahí Hurtado-Chong, Michael Blauth, Joerg Goldhahn, Nicolas S Bodmer, Lucas M Bachmann
BACKGROUND: Early identification of people at risk for a contralateral hip fracture would be desirable to favorably influence patients' prognosis. A recent systematic review failed to depict stringent patterns of risk parameters to be used for decision-making in clinical practice. OBJECTIVE: To perform a consensus study using the Delphi method to reach an expert consensus on predictive parameters for the occurrence of a fall and a contralateral hip fracture 1 and 3 years after hip fracture...
June 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/28534082/conformational-dynamics-and-alignment-properties-of-loop-lanthanide-binding-tags-lbts-studied-in-interleukin-1%C3%AE
#17
Dominic Barthelmes, Katja Barthelmes, Kai Schnorr, Hendrik R A Jonker, Bianca Bodmer, Karen N Allen, Barbara Imperiali, Harald Schwalbe
Encodable lanthanide binding tags (LBTs) have become an attractive tool in modern structural biology as they can be expressed as fusion proteins of targets of choice. Previously, we have demonstrated the feasibility of inserting encodable LBTs into loop positions of interleukin-1β (Barthelmes et al. in J Am Chem Soc 133:808-819, 2011). Here, we investigate the differences in fast dynamics of selected loop-LBT interleukin-1β constructs by measuring (15)N nuclear spin relaxation experiments. We show that the loop-LBT does not significantly alter the dynamic motions of the host protein in the sub-τc-timescale and that the loop-LBT adopts a rigid conformation with significantly reduced dynamics compared to the terminally attached encodable LBT leading to increased paramagnetic alignment strength...
July 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28503123/thromboelastometry-and-thrombelastography-analysis-under-normal-physiological-conditions-systematic-review
#18
Marcel Adler, Sandra Ivic, Nicolas S Bodmer, Hugo Ten Cate, Lucas M Bachmann, Walter A Wuillemin, Michael Nagler
BACKGROUND: Studies investigating thromboelastometry or thrombelastography analyses in a physiological context are scattered and not easy to access. OBJECTIVE: To systematically retrieve and describe published reports studying healthy subjects and targeting at the correlation of ROTEM® and TEG® measurements with conventional parameters of hemostasis. METHODS: Systematic Review: Papers were searched in Medline, Scopus and the Science Citation Index database...
April 2017: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/28443714/cme-orl-23-aufl%C3%A3-sung-indolente-raumforderung-wange-links
#19
Nora Tetter, Daniel Bodmer, Claudio Storck
No abstract text is available yet for this article.
April 2017: Praxis
https://www.readbyqxmd.com/read/28435326/the-association-between-thyroid-disorders-and-incident-gout-population-based-case-control-study
#20
Saskia G Bruderer, Christoph R Meier, Susan S Jick, Michael Bodmer
CONTEXT: Thyroid hormones influence kidney function and thereby might alter serum urate levels, a major risk factor for gouty arthritis. OBJECTIVE: To assess the risk of developing incident gout in association with hypothyroidism or hyperthyroidism. DESIGN: Retrospective population-based case-control analysis. SETTING: UK-based Clinical Practice Research Datalink, a primary care research database. PATIENTS: We identified adult patients with a diagnosis of incident gout between 1990 and 2014...
2017: Clinical Epidemiology
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