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JOURNAL ARTICLE
Calebe P Mendes, Wido R Albert, Zachary Amir, Marc Ancrenaz, Eric Ash, Badrul Azhar, Henry Bernard, Jedediah Brodie, Tom Bruce, Elliot Carr, Gopalasamy Reuben Clements, Glyn Davies, Nicolas J Deere, Yoan Dinata, Christl A Donnelly, Somphot Duangchantrasiri, Gabriella Fredriksson, Benoit Goossens, Alys Granados, Andrew Hearn, Jason Hon, Tom Hughes, Patrick Jansen, Kae Kawanishi, Margaret Kinnaird, Sharon Koh, Alice Latinne, Matthew Linkie, Federica Loi, Anthony J Lynam, Erik Meijaard, Jayasilan Mohd-Azlan, Jonathan H Moore, Senthilvel K S S Nathan, Dusit Ngoprasert, Wilson Novarino, Ilyas Nursamsi, Timothy O'Brien, Robert Ong, John Payne, Dolly Priatna, D Mark Rayan, Glen Reynolds, Rustam Rustam, Sasidhran Selvadurai, Amanda Shia, Muhammad Silmi, Pablo Sinovas, Kriangsak Sribuarod, Robert Steinmetz, Matthew J Struebig, Ronglarp Sukmasuang, Sunarto Sunarto, Tarmizi Tarmizi, Arjun Thapa, Carl Traeholt, Oliver R Wearn, Hariyo B Wibisono, Andreas Wilting, Seth Timothy Wong, Siew Te Wong, Jettie Word, Wen Xuan Chiok, Zainal Zahari Zainuddin, Matthew Scott Luskin
Information on tropical Asian vertebrates has traditionally been sparse, particularly when it comes to cryptic species inhabiting the dense forests of the region. Vertebrate populations are declining globally due to land-use change and hunting, the latter frequently referred as "defaunation." This is especially true in tropical Asia where there is extensive land-use change and high human densities. Robust monitoring requires that large volumes of vertebrate population data be made available for use by the scientific and applied communities...
April 22, 2024: Ecology
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JOURNAL ARTICLE
Laura D Zambrano, Margaret M Newhams, Regina M Simeone, Amanda B Payne, Michael Wu, Amber O Orzel-Lockwood, Natasha B Halasa, Jemima M Calixte, Pia S Pannaraj, Kanokporn Mongkolrattanothai, Julie A Boom, Leila C Sahni, Satoshi Kamidani, Kathleen Chiotos, Melissa A Cameron, Aline B Maddux, Katherine Irby, Jennifer E Schuster, Elizabeth H Mack, Austin Biggs, Bria M Coates, Kelly N Michelson, Katherine E Bline, Ryan A Nofziger, Hillary Crandall, Charlotte V Hobbs, Shira J Gertz, Sabrina M Heidemann, Tamara T Bradford, Tracie C Walker, Stephanie P Schwartz, Mary Allen Staat, Samina S Bhumbra, Janet R Hume, Michele Kong, Melissa S Stockwell, Thomas J Connors, Melissa L Cullimore, Heidi R Flori, Emily R Levy, Natalie Z Cvijanovich, Matt S Zinter, Mia Maamari, Cindy Bowens, Danielle M Zerr, Judith A Guzman-Cottrill, Ivan Gonzalez, Angela P Campbell, Adrienne G Randolph
Pediatric COVID-19 vaccination is effective in preventing COVID-19-related hospitalization, but duration of protection of the original monovalent vaccine during SARS-CoV-2 Omicron predominance merits evaluation, particularly given low coverage with updated COVID-19 vaccines. During December 19, 2021-October 29, 2023, the Overcoming COVID-19 Network evaluated vaccine effectiveness (VE) of ≥2 original monovalent COVID-19 mRNA vaccine doses against COVID-19-related hospitalization and critical illness among U...
April 18, 2024: MMWR. Morbidity and Mortality Weekly Report
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JOURNAL ARTICLE
Dustin Baldridge, Levi Kaster, Catherine Sancimino, Siddharth Srivastava, Sophie Molholm, Aditi Gupta, Inez Oh, Virginia Lanzotti, Daleep Grewal, Erin Rooney Riggs, Juliann M Savatt, Rachel Hauck, Abigail Sveden, John N Constantino, Joseph Piven, Christina A Gurnett, Maya Chopra, Heather Hazlett, Philip R O Payne
Monogenic disorders account for a large proportion of population-attributable risk for neurodevelopmental disabilities. However, the data necessary to infer a causal relationship between a given genetic variant and a particular neurodevelopmental disorder is often lacking. Recognizing this scientific roadblock, 13 Intellectual and Developmental Disabilities Research Centers (IDDRCs) formed a consortium to create the Brain Gene Registry (BGR), a repository pairing clinical genetic data with phenotypic data from participants with variants in putative brain genes...
April 17, 2024: Journal of Neurodevelopmental Disorders
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JOURNAL ARTICLE
Michelle DiGiacomo, Sara-Jane Roberts, Tim Luckett, David Symons, Georgia Ellis, Slavica Kochovska, Tony Warner, David C Currow, Deborah Parker, Karey Payne, Meera R Agar
OBJECTIVES: Family involvement in the lives of people who have dementia and live in long-term care is important, but family members may face challenges communicating and connecting with their loved one as dementia progresses. A type of therapeutic humor (Laughter Care) delivered by trained specialists aims to engage people with dementia who reside in long-term care through creative play and laughter. This study aimed to explore the perceptions of Laughter Care Specialists (LCSs) regarding families' engagement with the program...
April 8, 2024: Palliative & Supportive Care
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JOURNAL ARTICLE
C C Parker, P M Petersen, A D Cook, N W Clarke, C Catton, W R Cross, H Kynaston, W R Parulekar, R A Persad, F Saad, L Bower, G C Durkan, J Logue, C Maniatis, D Noor, H Payne, J Anderson, A K Bahl, F Bashir, D M Bottomley, K Brasso, L Capaldi, P W Cooke, C Chung, J Donohue, B Eddy, C M Heath, A Henderson, A Henry, R Jaganathan, H Jakobsen, N D James, J Joseph, K Lees, J Lester, H Lindberg, A Makar, S L Morris, N Oommen, P Ostler, L Owen, P Patel, A Pope, R Popert, R Raman, V Ramani, A Røder, I Sayers, M Simms, V Srinivasan, S Sundaram, K L Tarver, A Tran, P Wells, J Wilson, A M Zarkar, M K M Parmar, M R Sydes
BACKGROUND: The optimal timing of radiotherapy (RT) after radical prostatectomy for prostate cancer has been uncertain. RADICALS-RT compared efficacy and safety of adjuvant RT versus an observation policy with salvage RT for PSA failure. METHODS: RADICALS-RT was a randomised controlled trial enrolling patients with ≥1 risk factor (pT3/4, Gleason 7-10, positive margins, pre-op PSA≥10ng/ml) for recurrence after radical prostatectomy. Patients were randomised 1:1 to adjuvant RT ("Adjuvant-RT") or an observation policy with salvage RT for PSA failure ("Salvage-RT") defined as PSA≥0...
April 5, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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JOURNAL ARTICLE
Jack W Silcox, Karen Bennett, Allyson Copeland, Sarah Hargus Ferguson, Brennan R Payne
Although the impact of acoustic challenge on speech processing and memory increases as a person ages, older adults may engage in strategies that help them compensate for these demands. In the current preregistered study, older adults (n = 48) listened to sentences-presented in quiet or in noise-that were high constraint with either expected or unexpected endings or were low constraint with unexpected endings. Pupillometry and EEG were simultaneously recorded, and subsequent sentence recognition and word recall were measured...
April 4, 2024: Journal of Cognitive Neuroscience
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JOURNAL ARTICLE
Taylor D Payne, Lily R Dixon, Fiona C Schmidt, Joshua J Blakeslee, Alison E Bennett, Zachary D Schultz
Carotenoids are yellow, orange, and red pigments commonly found in plants. In leaves, these molecules are essential for photosynthesis, but they also play a major role in plant growth and development. Efficiently monitoring concentrations of specific carotenoids in plant tissues could help to explain plant responses to environmental stressors, infection and disease, fertilization, and other conditions. Previously, Raman methods have been used to demonstrate a correlation between plant fitness and the carotenoid content of leaves...
April 2, 2024: Analytical Methods: Advancing Methods and Applications
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JOURNAL ARTICLE
Sean McCann, Victória E Helfer, Stephen J Balevic, Chi D Hornik, Stuart L Goldstein, Julie Autmizguine, Marisa Meyer, Amira Al-Uzri, Sarah G Anderson, Elizabeth H Payne, Sitora Turdalieva, Daniel Gonzalez
Dexmedetomidine is a sedative used in both adults and off-label in children with considerable reported pharmacokinetic (PK) interindividual variability affecting drug exposure across populations. Several published models describe the population PKs of dexmedetomidine in neonates, infants, children, and adolescents, though very few have been externally evaluated. A prospective PK dataset of dexmedetomidine plasma concentrations in children and young adults aged 0.01-19.9 years was collected as part of a multicenter opportunistic PK study...
March 28, 2024: Journal of Clinical Pharmacology
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JOURNAL ARTICLE
Dheeraj R Pasham, Francesco Tombesi, Petra Suková, Michal Zajaček, Suvendu Rakshit, Eric Coughlin, Peter Kosec, Vladimír Karas, Megan Masterson, Andrew Mummery, Thomas W-S Holoien, Muryel Guolo, Jason Hinkle, Bart Ripperda, Vojtěch Witzany, Ben Shappee, Erin Kara, Assaf Horesh, Sjoert van Velzen, Itai Sfaradi, David Kaplan, Noam Burger, Tara Murphy, Ronald Remillard, James F Steiner, Thomas Wevers, Riccardo Arcodia, Johannes Buchner, Andrea Merloni, Adam Malyali, Andy Fabian, Michael Fausnaugh, Tansu Daylan, Diego Altamirano, Anna Payne, Elizabeth C Ferraraa
Binaries containing a compact object orbiting a supermassive black hole are thought to be precursors of gravitational wave events, but their identification has been extremely challenging. Here, we report quasi-periodic variability in x-ray absorption, which we interpret as quasi-periodic outflows (QPOuts) from a previously low-luminosity active galactic nucleus after an outburst, likely caused by a stellar tidal disruption. We rule out several models based on observed properties and instead show using general relativistic magnetohydrodynamic simulations that QPOuts, separated by roughly 8...
March 29, 2024: Science Advances
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JOURNAL ARTICLE
Lyson Tenthani, Victoria Seffren, Alinune Nathanael Kabaghe, Francis Ogollah, Monica Soko, Ruchi Yadav, Felix Kayigamba, Danielle Payne, Nellie Wadonda-Kabondo, Elizabeth Kampira, Tyson Volkmann, Nandita S Sugandhi, Karl Seydel, Eric Rogier, Julie I Thwing, Julie R Gutman
Many SARS-CoV-2 infections are asymptomatic, thus reported cases underestimate actual cases. To improve estimates, we conducted surveillance for SARS-CoV-2 seroprevalence among pregnant women attending their first antenatal care visit (ANC1) from June 2021 through May 2022. We administered a questionnaire to collect demographic, risk factors, and COVID-19 vaccine status information and tested dried blood spots for SARS-CoV-2 antibodies. Although <1% of ANC1 participants reported having had COVID-19, monthly SARS-CoV-2 seroprevalence increased from 15...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
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JOURNAL ARTICLE
Anna Funk, Todd A Florin, Nathan Kuppermann, Yaron Finkelstein, Alissa Kazakoff, Michael Baldovsky, Daniel J Tancredi, Kristen Breslin, Kelly R Bergmann, Michael Gardiner, Christopher M Pruitt, Deborah R Liu, Mark I Neuman, Matthew Wilkinson, Lilliam Ambroggio, Xiao-Li Pang, Simon Cauchemez, Richard Malley, Terry P Klassen, Bonita E Lee, Daniel C Payne, Salaheddin M Mahmud, Stephen B Freedman
BACKGROUND: Asymptomatic SARS-CoV-2 infection in children is highly prevalent but its acute and chronic implications have been minimally described. METHODS: In this controlled case-ascertained household transmission study, we recruited asymptomatic children <18 years with SARS-CoV-2 nucleic acid testing performed at 12 tertiary care pediatric institutions in Canada and the United States. We attempted to recruit all test-positive children and 1 to 3 test-negative, site-matched controls...
March 26, 2024: Clinical Infectious Diseases
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JOURNAL ARTICLE
Thaer Khoury, Lucas Mendicino, Rochelle Payne Ondracek, Song Yao, Warren Davis, Angela R Omilian, Marilyn L Kwan, Janise M Roh, Lia D'Addario, Emily Valice, Daniel Fernandez, Isaac J Ergas, Alfredo V Chua, Christine B Ambrosone, Lawrence H Kushi
IMPORTANCE: It is unclear whether breast cancer (BC) with low ERBB2 expression (ERBB2-low) is a distinct clinical, pathological, and epidemiological entity from BC classified as no ERBB2 expression (ERBB2-negative). OBJECTIVE: To evaluate the clinical, pathological, and epidemiologic features of BC with ERBB2-low expression compared with ERBB2-negative BC in a large population study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was conducted as part of the Pathways Study, a prospective, racially and ethnically diverse cohort study of women with BC enrolled between 2006 and 2013 in Kaiser Permanente Northern California (KPNC)...
March 4, 2024: JAMA Network Open
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REVIEW
Ivy Kekessie, Katarzyna Wegner, Isamir Martinez, Michael E Kopach, Timothy D White, Janine K Tom, Martin N Kenworthy, Fabrice Gallou, John Lopez, Stefan G Koenig, Philippa R Payne, Stefan Eissler, Balasubramanian Arumugam, Changfeng Li, Subha Mukherjee, Albert Isidro-Llobet, Olivier Ludemann-Hombourger, Paul Richardson, Jörg Kittelmann, Daniel Sejer Pedersen, Leendert J van den Bos
Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many attractive targets are poorly tractable by small molecules, generating a need for new therapeutic modalities. Due to their biocompatibility profile and structural versatility, peptide-based therapeutics are a possible solution. Additionally, in the past two decades, advances in peptide design, delivery, formulation, and devices have occurred, making therapeutic peptides an attractive modality. However, peptide manufacturing is often limited to solid-phase peptide synthesis (SPPS), liquid phase peptide synthesis (LPPS), and to a lesser extent hybrid SPPS/LPPS, with SPPS emerging as a predominant platform technology for peptide synthesis...
March 20, 2024: Journal of Organic Chemistry
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JOURNAL ARTICLE
Kenneth R Holmes, Gaurav S Gulsin, Timothy A Fairbairn, Lynne Hurwitz-Koweek, Hitoshi Matsuo, Bjarne L Nørgaard, Jesper M Jensen, Niels-Peter Rønnow Sand, Koen Nieman, Jeroen J Bax, Gianluca Pontone, Kavitha M Chinnaiyan, Mark G Rabbat, Tetsuya Amano, Tomohiro Kawasaki, Takashi Akasaka, Hironori Kitabata, Campbell Rogers, Manesh R Patel, Geoffrey W Payne, Jonathon A Leipsic, Stephanie L Sellers
Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this secondary analysis, participants from the ADVANCE registry evaluated for suspected CAD from July 15, 2015, to October 20, 2017, who were found to have coronary stenosis of 30% or greater at coronary CT angiography (CCTA) were included if they had known smoking status and underwent CT-FFR and V/M analysis...
April 2024: Radiology. Cardiothoracic imaging
#15
JOURNAL ARTICLE
Sydney J Conner, Justinne R Guarin, Thanh T Le, Jackson P Fatherree, Charlotte Kelley, Samantha L Payne, Savannah R Parker, Hanan Bloomer, Crystal Zhang, Kenneth Salhany, Rachel A McGinn, Emily Henrich, Anna Yui, Deepti Srinivasan, Hannah Borges, Madeleine J Oudin
BACKGROUND: Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on invasion and metastasis rely on human breast cancer cell lines. While it is known that these cells have different properties and abilities for growth and metastasis, the in vitro morphological, proliferative, migratory, and invasive behavior of these cell lines and their correlation to in vivo behavior is poorly understood...
March 11, 2024: Breast Cancer Research: BCR
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JOURNAL ARTICLE
James R Jones, Daniel Gottlieb, Andrew J McMurry, Ashish Atreja, Pankaja M Desai, Brian E Dixon, Philip R O Payne, Anil J Saldanha, Prabhu Shankar, Yauheni Solad, Adam B Wilcox, Momeena S Ali, Eugene Kang, Andrew M Martin, Elizabeth Sprouse, David E Taylor, Michael Terry, Vladimir Ignatov, Kenneth D Mandl
OBJECTIVE: To evaluate the real-world performance of the SMART/HL7 Bulk Fast Health Interoperability Resources (FHIR) Access Application Programming Interface (API), developed to enable push button access to electronic health record data on large populations, and required under the 21st Century Cures Act Rule. MATERIALS AND METHODS: We used an open-source Bulk FHIR Testing Suite at 5 healthcare sites from April to September 2023, including 4 hospitals using electronic health records (EHRs) certified for interoperability, and 1 Health Information Exchange (HIE) using a custom, standards-compliant API build...
March 6, 2024: Journal of the American Medical Informatics Association: JAMIA
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JOURNAL ARTICLE
Ardythe L Morrow, Daniel C Payne, Shannon C Conrey, Meredith McMorrow, Monica M McNeal, Liang Niu, Allison R Burrell, Elizabeth P Schlaudecker, Claire Mattison, Rachel M Burke, Emily DeFranco, Zheyi Teoh, Jens Wrammert, Lydia J Atherton, Natalie J Thornburg, Mary A Staat
BACKGROUND: The endemic coronaviruses OC43, HKU1, NL63 and 229E cause cold-like symptoms and are related to SARS-CoV-2, but their natural histories are poorly understood. In a cohort of children followed from birth to 4 years, we documented all coronavirus infections, including SARS-CoV-2, to understand protection against subsequent infections with the same virus (homotypic immunity) or a different coronavirus (heterotypic immunity). METHODS: Mother-child pairs were enrolled in metropolitan Cincinnati during the third trimester of pregnancy in 2017-18...
March 5, 2024: Journal of the Pediatric Infectious Diseases Society
#18
JOURNAL ARTICLE
E N Barker, J R Payne, H Wilson
OBJECTIVES: Angiostrongylosis is a significant differential for a diverse range of clinical signs in dogs, many of whom present acutely and sometimes with fatal consequences. Point-of-care diagnostic assays include a commercially available Angiostrongylus vasorum qualitative direct lateral flow assay. MATERIALS AND METHODS: Case records from one referral centre from dogs with an invalid A. vasorum lateral flow assay, comprising an absent control line alongside a visible test line, were reviewed...
March 4, 2024: Journal of Small Animal Practice
#19
JOURNAL ARTICLE
Kevin M Wymer, Sayi P Boddu, Mouneeb Choudry, Gopal Narang, Daniel J Heidenberg, Nicolette G Payne, Marlene Girardo, Mitchell R Humphries, Karen L Stern
OBJECTIVE: To characterize the impact of nephrolithiasis diagnosis and treatment on healthcare utilization and identify predictors of barriers to care in the patient population. METHODS: We conducted a retrospective cohort study using the All of Us Database, an NIH database targeting recruitment of underrepresented populations. Patients with a diagnosis of kidney stones were included and matched to a control group. Primary outcomes were patients' self-reported healthcare access and utilization...
March 1, 2024: Urology
#20
JOURNAL ARTICLE
Jennifer DeCuir, Amanda B Payne, Wesley H Self, Elizabeth A K Rowley, Kristin Dascomb, Malini B DeSilva, Stephanie A Irving, Shaun J Grannis, Toan C Ong, Nicola P Klein, Zachary A Weber, Sarah E Reese, Sarah W Ball, Michelle A Barron, Allison L Naleway, Brian E Dixon, Inih Essien, Daniel Bride, Karthik Natarajan, Bruce Fireman, Ami B Shah, Erica Okwuazi, Ryan Wiegand, Yuwei Zhu, Adam S Lauring, Emily T Martin, Manjusha Gaglani, Ithan D Peltan, Samuel M Brown, Adit A Ginde, Nicholas M Mohr, Kevin W Gibbs, David N Hager, Matthew Prekker, Amira Mohamed, Vasisht Srinivasan, Jay S Steingrub, Akram Khan, Laurence W Busse, Abhijit Duggal, Jennifer G Wilson, Steven Y Chang, Christopher Mallow, Jennie H Kwon, Matthew C Exline, Cristie Columbus, Ivana A Vaughn, Basmah Safdar, Jarrod M Mosier, Estelle S Harris, Jonathan D Casey, James D Chappell, Carlos G Grijalva, Sydney A Swan, Cassandra Johnson, Nathaniel M Lewis, Sascha Ellington, Katherine Adams, Mark W Tenforde, Clinton R Paden, Fatimah S Dawood, Katherine E Fleming-Dutra, Diya Surie, Ruth Link-Gelles
In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5) COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease. However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available. This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks...
February 29, 2024: MMWR. Morbidity and Mortality Weekly Report
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