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R. Payne

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https://www.readbyqxmd.com/read/28816473/the-effects-of-context-on-processing-words-during-sentence-reading-among-adults-varying-in-age-and-literacy-skill
#1
Allison A Steen-Baker, Shukhan Ng, Brennan R Payne, Carolyn J Anderson, Kara D Federmeier, Elizabeth A L Stine-Morrow
The facilitation of word processing by sentence context reflects the interaction between the build-up of message-level semantics and lexical processing. Yet, little is known about how this effect varies through adulthood as a function of reading skill. In this study, Participants 18-64 years old with a range of literacy competence read simple sentences as their eye movements were monitored. We manipulated the predictability of a sentence-final target word, operationalized as cloze probability. First fixation durations showed an interaction between age and literacy skill, decreasing with age among more skilled readers but increasing among less skilled readers...
August 2017: Psychology and Aging
https://www.readbyqxmd.com/read/28815138/integrative-network-and-transcriptomics-based-approach-predicts-genotype-specific-drug-combinations-for-melanoma
#2
Kelly E Regan, Philip R O Payne, Fuhai Li
Computational methods for drug combination predictions are needed to identify effective therapies that improve durability and prevent drug resistance in an efficient manner. In this paper, we present SynGeNet, a computational method that integrates transcriptomics data characterizing disease and drug z-score profiles with network mining algorithms in order to predict synergistic drug combinations. We compare SynGeNet to other available transcriptomics-based tools to predict drug combinations validated across melanoma cell lines in three genotype groups: BRAF-mutant, NRAS-mutant and combined...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28809549/mesocosm-studies-on-the-efficacy-of-bioamended-activated-carbon-for-treating-pcb-impacted-sediment
#3
Rayford B Payne, Upal Ghosh, Harold Douglas May, Christopher W Marshall, Kevin R Sowers
This report describes results of a bench-scale treatability study to evaluate the efficacy of bioaugmentation with bioamended activated carbon (AC) for in-situ treatment of polychlorinated biphenyl (PCB) impacted sediments. To this end, the ability of PCB transforming microorganisms to degrade and reduce the overall concentration of PCBs in sediment was determined in 2 L recirculating mesocosms designed to simulate conditions in Abraham's Creek in Quantico, Virginia. Ten sediment mesocosms were tested for the effects of AC alone, AC with slow release electron donor (cellulose) and different concentrations and combinations of PCB dehalogenating and degrading microorganisms added as bioamendments...
August 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28797312/self-perceived-difficulties-in-everyday-function-precede-cognitive-decline-among-older-adults-in-the-active-study
#4
Sarah Tomaszewski Farias, Tania Giovannetti, Brennan R Payne, Michael Marsiske, George W Rebok, K Warner Schaie, Kelsey R Thomas, Sherry L Willis, Joseph M Dzierzewski, Frederick Unverzagt, Alden L Gross
OBJECTIVES: Careful characterization of how functional decline co-evolves with cognitive decline in older adults has yet to be well described. Most models of neurodegenerative disease postulate that cognitive decline predates and potentially leads to declines in everyday functional abilities; however, there is mounting evidence that subtle decline in instrumental activities of daily living (IADLs) may be detectable in older individuals who are still cognitively normal. METHODS: The present study examines how the relationship between change in cognition and change in IADLs are best characterized among older adults who participated in the ACTIVE trial...
August 11, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28782813/incorporating-lsrk-ai-2-quorum-quenching-capability-in-a-functionalized-biopolymer-capsule
#5
Melissa K Rhoads, Pricila Hauk, Jessica Terrell, Chen-Yu Tsao, Hyuntaek Oh, Srinivasa R Raghavan, Sheref S Mansy, Gregory F Payne, William E Bentley
Antibacterial resistance is an issue of increasing severity as current antibiotics are losing their effectiveness and fewer antibiotics are being developed. New methods for combating bacterial virulence are required. Modulating molecular communication among bacteria can alter phenotype, including attachment to epithelia, biofilm formation and even toxin production. Intercepting and modulating communication networks provide a means to attenuate virulence without directly interacting with the bacteria of interest...
August 7, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28781182/regional-transport-source-apportionment-and-health-impact-of-pm10-bound-polycyclic-aromatic-hydrocarbons-in-singapore-s-atmosphere
#6
Dejan Urbančok, Anthony J R Payne, Richard D Webster
A study of 16 United States Environmental Protection Agency (USEPA) priority listed PAHs associated with particulate matter ≤ 10 μm (PM10) was conducted in Singapore during the period 29th May 2015 to 28th May 2016. The sampling period coincided with an extensive, regional smoke haze episode (5th September to 25th October) that occurred as a result of forest and peat fires in neighboring Indonesia. Throughout this study, 54 atmospheric PM10 samples were collected in 24 h periods using a high volume sampler (HVS) and quarts fiber filters (QFF) as the collection medium...
August 3, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28780159/pyridine-pyrimidine-amides-that-prevent-hgf-induced-epithelial-scattering-by-two-distinct-mechanisms
#7
Adam Siddiqui-Jain, Jacob P Hoj, J Blade Hargiss, Taylor H Hoj, Carter J Payne, Collin A Ritchie, Steven R Herron, Colette Quinn, Jeffrey T Schuler, Marc D H Hansen
Stimulation of cultured epithelial cells with scatter factor/hepatocyte growth factor (HGF) results in individual cells detaching and assuming a migratory and invasive phenotype. Epithelial scattering recapitulates cancer progression and studies have implicated HGF signaling as a driver of cancer metastasis. Inhibitors of HGF signaling have been proposed to act as anti-cancer agents. We previously screened a small molecule library for compounds that block HGF-induced epithelial scattering. Most hits identified in this screen exhibit anti-mitotic properties...
July 25, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28768901/essential-role-for-ccr6-in-certain-inflammatory-diseases-demonstrated-using-specific-antagonist-and-knockin-mice
#8
Remy Robert, Caroline Ang, Guizhi Sun, Laurent Juglair, Ee X Lim, Linda J Mason, Natalie L Payne, Claude Ca Bernard, Charles R Mackay
The chemokine receptor CCR6 marks subsets of T cells and innate lymphoid cells that produce IL-17 and IL-22, and as such may play a role in the recruitment of these cells to certain inflammatory sites. However, the precise role of CCR6 has been controversial, in part because no effective monoclonal antibody (mAb) inhibitors against this receptor exist for use in mouse models of inflammation. We circumvented this problem using transgenic mice expressing human CCR6 (hCCR6) under control of its native promoter (hCCR6-Tg/mCCR6-/-)...
August 3, 2017: JCI Insight
https://www.readbyqxmd.com/read/28758789/misunderstanding-the-behavior-priming-controversy-comment-on-payne-brown-iannuzzi-and-loersch-2016
#9
David R Shanks
There has been considerable controversy around the limits and reproducibility of so-called "behavior" priming effects. Payne, Brown-Iannuzzi, and Loersch (2016) reported a series of 6 experiments on the effects of primes on participants' bets in a simulated blackjack game, and claimed that their findings not only establish the reality of behavior priming beyond dispute, but also demonstrate that this form of priming has the crucial hallmark of occurring outside participants' awareness and control. I describe a statistical model that does not distinguish automatic and controlled processes, but which nonetheless reproduces Payne et al...
August 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28754680/versican-derived-matrikines-regulate-batf3-dendritic-cell-differentiation-and-promote-t-cell-infiltration-in-colorectal-cancer
#10
Chelsea Hope, Philip B Emmerich, Athanasios Papadas, Adam Pagenkopf, Kristina A Matkowskyj, Dana R Van De Hey, Susan N Payne, Linda Clipson, Natalie S Callander, Peiman Hematti, Shigeki Miyamoto, Michael G Johnson, Dustin A Deming, Fotis Asimakopoulos
Colorectal cancer originates within immunologically complex microenvironments. To date, the benefits of immunotherapy have been modest, except in neoantigen-laden mismatch repair-deficient tumors. Approaches to enhance tumor-infiltrating lymphocytes in the tumor bed may substantially augment clinical immunotherapy responses. In this article, we report that proteolysis of the tolerogenic matrix proteoglycan versican (VCAN) strongly correlated with CD8(+) T cell infiltration in colorectal cancer, regardless of mismatch repair status...
July 28, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28752836/corrigendum-large-scale-production-of-megakaryocytes-from-human-pluripotent-stem-cells-by-chemically-defined-forward-programming
#11
Thomas Moreau, Amanda L Evans, Louella Vasquez, Marloes R Tijssen, Ying Yan, Matthew W Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M Hobbs, Dean C Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H Ouwehand, Roger A Pedersen, Cedric Ghevaert
This corrects the article DOI: 10.1038/ncomms11208.
July 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28752540/the-effects-of-traffic-light-labelling-versus-cartoon-labelling-on-food-and-beverage-purchases-in-a-children-s-hospital-setting
#12
O R Whitt, S B Jilcott Pitts, A P Rafferty, C R Payne, S W Ng
This study's purpose was to examine changes in healthy and unhealthy items purchased following the implementation of traffic light and cartoon labelling in a small retail food venue (Café Bay) in a children's hospital in eastern North Carolina. Between October 2015 and March 2016, daily food and beverage sales from Café Bay were obtained during baseline, traffic light labelling, a washout period, cartoon labelling (on healthy foods only) and a final washout period. Pearson chi-squared tests and multiple linear regressions were used to examine effects of labelling strategies, controlling for the holidays...
July 28, 2017: Pediatric Obesity
https://www.readbyqxmd.com/read/28727539/state-and-local-chronic-disease-surveillance-using-electronic-health-record-systems
#13
Michael Klompas, Noelle M Cocoros, John T Menchaca, Diana Erani, Ellen Hafer, Brian Herrick, Mark Josephson, Michael Lee, Michelle D Payne Weiss, Bob Zambarano, Karen R Eberhardt, Jessica Malenfant, Laura Nasuti, Thomas Land
OBJECTIVES: To assess the feasibility of chronic disease surveillance using distributed analysis of electronic health records and to compare results with Behavioral Risk Factor Surveillance System (BRFSS) state and small-area estimates. METHODS: We queried the electronic health records of 3 independent Massachusetts-based practice groups using a distributed analysis tool called MDPHnet to measure the prevalence of diabetes, asthma, smoking, hypertension, and obesity in adults for the state and 13 cities...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28724806/nicotinamide-mononucleotide-requires-sirt3-to-improve-cardiac-function-and-bioenergetics-in-a-friedreich-s-ataxia-cardiomyopathy-model
#14
Angelical S Martin, Dennis M Abraham, Kathleen A Hershberger, Dhaval P Bhatt, Lan Mao, Huaxia Cui, Juan Liu, Xiaojing Liu, Michael J Muehlbauer, Paul A Grimsrud, Jason W Locasale, R Mark Payne, Matthew D Hirschey
Increasing NAD+ levels by supplementing with the precursor nicotinamide mononucleotide (NMN) improves cardiac function in multiple mouse models of disease. While NMN influences several aspects of mitochondrial metabolism, the molecular mechanisms by which increased NAD+ enhances cardiac function are poorly understood. A putative mechanism of NAD+ therapeutic action exists via activation of the mitochondrial NAD+-dependent protein deacetylase sirtuin 3 (SIRT3). We assessed the therapeutic efficacy of NMN and the role of SIRT3 in the Friedreich's ataxia cardiomyopathy mouse model (FXN-KO)...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28714466/quantifying-the-critical-thickness-of-electron-hybridization-in-spintronics-materials
#15
T Pincelli, V Lollobrigida, F Borgatti, A Regoutz, B Gobaut, C Schlueter, T-L Lee, D J Payne, M Oura, K Tamasaku, A Y Petrov, P Graziosi, F Miletto Granozio, M Cavallini, G Vinai, R Ciprian, C H Back, G Rossi, M Taguchi, H Daimon, G van der Laan, G Panaccione
In the rapidly growing field of spintronics, simultaneous control of electronic and magnetic properties is essential, and the perspective of building novel phases is directly linked to the control of tuning parameters, for example, thickness and doping. Looking at the relevant effects in interface-driven spintronics, the reduced symmetry at a surface and interface corresponds to a severe modification of the overlap of electron orbitals, that is, to a change of electron hybridization. Here we report a chemically and magnetically sensitive depth-dependent analysis of two paradigmatic systems, namely La1-xSrxMnO3 and (Ga,Mn)As...
July 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28710893/fracture-of-the-medial-intercondylar-eminence-of-the-tibia-in-horses-treated-by-arthroscopic-fragment-removal-21-horses
#16
L M Rubio-Martínez, R Redding, B Bladon, H Wilderjans, R J Payne, C Tessier, O Geffroy, R Parker, C Bell, F A Collingwood
BACKGROUND: Fractures of the medial intercondylar eminence of the tibia (MICET) are scarcely reported in horses. OBJECTIVES: To report the clinical and diagnostic findings, surgical treatment and outcome in a series of horses presented with MICET fracture and treated with arthroscopic fragment removal. STUDY DESIGN: Multi-centre retrospective case series. METHODS: Case records of horses diagnosed with MICET fractures that had undergone surgical treatment were reviewed...
July 15, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28695891/the-endothelial-transcription-factor-erg-mediates-angiopoietin-1-dependent-control-of-notch-signalling-and-vascular-stability
#17
A V Shah, G M Birdsey, C Peghaire, M E Pitulescu, N P Dufton, Y Yang, I Weinberg, L Osuna Almagro, L Payne, J C Mason, H Gerhardt, R H Adams, A M Randi
Notch and Angiopoietin-1 (Ang1)/Tie2 pathways are crucial for vascular maturation and stability. Here we identify the transcription factor ERG as a key regulator of endothelial Notch signalling. We show that ERG controls the balance between Notch ligands by driving Delta-like ligand 4 (Dll4) while repressing Jagged1 (Jag1) expression. In vivo, this regulation occurs selectively in the maturing plexus of the mouse developing retina, where Ang1/Tie2 signalling is active. We find that ERG mediates Ang1-dependent regulation of Notch ligands and is required for the stabilizing effects of Ang1 in vivo...
July 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28690116/evaluating-pathologic-response-of-breast-cancer-to-neoadjuvant-chemotherapy-with-computer-extracted-features-from-contrast-enhanced-ultrasound-videos
#18
Qi Zhang, Congcong Yuan, Wei Dai, Lei Tang, Jun Shi, Zuoyong Li, Man Chen
PURPOSE: To extract quantitative perfusion and texture features with computer assistance from contrast-enhanced ultrasound (CEUS) videos of breast cancer before and after neoadjuvant chemotherapy (NAC), and to evaluate pathologic response to NAC with these features. METHODS: Forty-two CEUS videos with 140,484 images were acquired from 21 breast cancer patients pre- and post-NAC. Time-intensity curve (TIC) features were calculated including the difference between area under TIC within a tumor and that within a computer-detected reference region (AUT_T-R)...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28682087/emotional-coherence-in-early-and-later-adulthood-during-sadness-reactivity-and-regulation
#19
Monika Lohani, Brennan R Payne, Derek M Isaacowitz
The current study reports the first investigation of age-related changes in emotional coherence across multiple response systems (experiential, physiological, and expressive) in sadness reactivity and regulation. Some accounts indirectly suggest that blunted physiological responses to emotional stimuli (e.g., Mendes, 2010) may lead to an age-related decline in emotional coherence, whereas a conflicting account suggests that age-relevant content can modulate responses across multiple systems (e.g., Kunzmann & Grühn, 2005), which has the potential to increase emotional coherence in older adults...
July 6, 2017: Emotion
https://www.readbyqxmd.com/read/28677146/genes-essential-for-phototrophic-growth-by-a-purple-alphaproteobacterium
#20
Jianming Yang, Liang Yin, Faith H Lessner, Ernesto S Nakayasu, Samuel H Payne, Kathryn R Fixen, Larry Gallagher, Caroline S Harwood
We used Tn-seq to identify genes essential for phototrophic growth by the purple bacterium Rhodopseudomonas palustris. We identified 167 genes required for anaerobic growth on acetate in light, 35 of which are annotated as photosynthesis genes. We verified the essentiality of many of these genes by analyzing the phenotypes of independently generated mutants that had altered pigmentation. We also identified three genes, two possibly involved in biogenesis of the membrane-bound photosynthetic apparatus and one for phosphadidylcholine biosynthesis, that were not known to be essential for phototrophic growth...
July 5, 2017: Environmental Microbiology
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