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R. Payne

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https://www.readbyqxmd.com/read/29462609/contextual-constraints-on-lexico-semantic-processing-in-aging-evidence-from-single-word-event-related-brain-potentials
#1
Brennan R Payne, Kara D Federmeier
The current study reports the effects of accumulating contextual constraints on neural indices of lexico-semantic processing (i.e., effects of word frequency and orthographic neighborhood) as a function of normal aging. Event-related brain potentials were measured from a sample of older adults as they read sentences that were semantically congruent, provided only syntactic constraints (syntactic prose), or were random word strings. A linear mixed-effects modeling approach was used to probe the effects of accumulating contextual constraints on N400 responses to individual words...
February 17, 2018: Brain Research
https://www.readbyqxmd.com/read/29451338/can-dimedone-be-used-to-study-selenoproteins-an-investigation-into-the-reactivity-of-dimedone-towards-oxidized-forms-of-selenocysteine
#2
N Connor Payne, Drew R Barber, Erik L Ruggles, Robert J Hondal
Dimedone is a widely used reagent to assess the redox state of cysteine-containing proteins as it will alkylate sulfenic acid residues, but not sulfinic acid residues. While it has been reported that dimedone can label selenenic acid residues in selenoproteins, we investigated the stability, and reversibility of this label in a model peptide system. We also wondered whether dimedone could be used to detect seleninic acid residues. We used benzenesulfinic acid, benzeneseleninic acid, and model selenocysteine-containing peptides to investigate possible reactions with dimedone...
February 16, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29434668/quantitative-trait-loci-for-cell-wall-composition-traits-measured-using-near-infrared-spectroscopy-in-the-model-c4-perennial-grass-panicum-hallii
#3
Elizabeth R Milano, Courtney E Payne, Ed Wolfrum, John Lovell, Jerry Jenkins, Jeremy Schmutz, Thomas E Juenger
Background: Biofuels derived from lignocellulosic plant material are an important component of current renewable energy strategies. Improvement efforts in biofuel feedstock crops have been primarily focused on increasing biomass yield with less consideration for tissue quality or composition. Four primary components found in the plant cell wall contribute to the overall quality of plant tissue and conversion characteristics, cellulose and hemicellulose polysaccharides are the primary targets for fuel conversion, while lignin and ash provide structure and defense...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29414640/malondialdehyde-acetaldehyde-antibody-concentrations-in-rheumatoid-arthritis-and-other-rheumatic-conditions
#4
Ted R Mikuls, Michael J Duryee, Bryant R England, Daniel R Anderson, Michelene Hearth-Holmes, Kaihong Su, Kaleb Michaud, Jeffrey B Payne, Harlan Sayles, Carlos Hunter, Jacob D McGowan, Lynell W Klassen, Geoffrey M Thiele
OBJECTIVE: To compare anti-malondialdehyde-acetaldehyde (MAA) antibody concentrations between rheumatoid arthritis (RA) patients and healthy and rheumatic disease controls. METHODS: Anti-MAA antibody (IgA, IgM, IgG) was measured using ELISA and banked serum from patients with RA (n = 284), osteoarthritis (OA, n = 330), spondyloarthropathy (SpA, n = 50), and systemic lupus erythematosus (SLE, n = 88) as well as healthy controls (n = 82). Anti-MAA antibody concentrations and the frequency of positivity were compared across groups...
February 1, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29408148/how-struggling-adult-readers-use-contextual-information-when-comprehending-speech-evidence-from-event-related-potentials
#5
Shukhan Ng, Brennan R Payne, Elizabeth A L Stine-Morrow, Kara D Federmeier
We investigated how struggling adult readers make use of sentence context to facilitate word processing when comprehending spoken language, conditions under which print decoding is not a barrier to comprehension. Stimuli were strongly and weakly constraining sentences (as measured by cloze probability), which ended with the most expected word based on those constraints or an unexpected but plausible word. Community-dwelling adults with varying literacy skills listened to continuous speech while their EEG was recorded...
February 2, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29395248/corrigendum-to-attractive-names-sustain-increased-vegetable-intake-in-schools-prev-med-55-4-2012-330-332
#6
Brian Wansink, David R Just, Collin R Payne, Matthew Z Klinger
No abstract text is available yet for this article.
January 23, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29389303/clinical-consensus-statement-balloon-dilation-of-the-sinuses
#7
Jay F Piccirillo, Spencer C Payne, Richard M Rosenfeld, Fuad M Baroody, Pete S Batra, John M DelGaudio, David R Edelstein, Andrew P Lane, Amber U Luong, R Peter Manes, Edward D McCoul, Michael P Platt, Douglas D Reh, Maureen D Corrigan
Objective To develop a clinical consensus statement on the use of sinus ostial dilation (SOD) of the paranasal sinuses. Methods An expert panel of otolaryngologists was assembled to represent general otolaryngology and relevant subspecialty societies. The target population is adults 18 years or older with chronic or recurrent rhinosinusitis (with or without nasal polyps, with or without prior sinus surgery) for whom SOD is being recommended, defined as endoscopic use of a balloon device to enlarge or open the outflow tracts of the maxillary, frontal, or sphenoid sinuses, as a standalone procedure or with endoscopic surgery...
February 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29385824/the-psychoses-of-menstruation-and-childbearingby-ian-brockington-m-d-f-r-c-p-cambridge-england-cambridge-university-press-2017-391-pp-140-00-hardcover
#8
Jennifer L Payne
No abstract text is available yet for this article.
February 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29377865/validity-evidence-for-a-serious-game-to-assess-performance-on-critical-pediatric-emergency-medicine-scenarios
#9
James M Gerard, Anthony J Scalzo, Matthew A Borgman, Christopher M Watson, Chelsie E Byrnes, Todd P Chang, Marc Auerbach, David O Kessler, Brian L Feldman, Brian S Payne, Sohail Nibras, Riti K Chokshi, Joseph O Lopreiato
INTRODUCTION: We developed a first-person serious game, PediatricSim, to teach and assess performances on seven critical pediatric scenarios (anaphylaxis, bronchiolitis, diabetic ketoacidosis, respiratory failure, seizure, septic shock, and supraventricular tachycardia). In the game, players are placed in the role of a code leader and direct patient management by selecting from various assessment and treatment options. The objective of this study was to obtain supportive validity evidence for the PediatricSim game scores...
January 26, 2018: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/29377354/redirecting-adult-mesenchymal-stromal-cells-to-the-brain-a-new-approach-for-treating-cns-autoimmunity-and-neuroinflammation
#10
REVIEW
Jasmine J Wilson, Kerrie Foyle, Jade Foeng, Todd Norton, Duncan R McKenzie, Natalie Payne, Claude C Bernard, Shaun R McColl, Iain Comerford
Mesenchymal stromal cells or stem cells (MSCs) have been shown to participate in tissue repair and are immunomodulatory in neuropathological settings. Given this, their potential use in developing a new generation of personalized therapies for autoimmune and inflammatory diseases of the central nervous system (CNS) will be explored. To effectively exert these effector functions, MSCs must first gain entry into damaged neural tissues, a process that has been demonstrated to be a limiting factor in their therapeutic efficacy...
January 29, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29370400/the-interval-between-brainstem-death-and-cardiac-assessment-influences-the-retrieval-of-hearts-for-transplantation
#11
Ioannis Dimarakis, Nicholas R Banner, Sally Rushton, Ha Sum Esther Wong, Marius Berman, Neil Howell, John Payne, John Dark, Jenny Mehew, Rajamiyer Venkateswaran
OBJECTIVES: The optimum time after brainstem death (BSD) at which to assess the function of donor hearts is unknown. We hypothesized that a longer interval may be associated with a higher transplantation rate due to improved function. METHODS: Data were obtained from the UK Transplant Registry for the period between April 2010 and March 2015. The time when fixed dilated pupils were first noted in the donor was considered as the time of BSD. Retrieval was defined as the time when the abdominal organs were surgically perfused...
January 22, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29367401/phanerozoic-po2-and-the-early-evolution-of-terrestrial-animals
#12
Sandra R Schachat, Conrad C Labandeira, Matthew R Saltzman, Bradley D Cramer, Jonathan L Payne, C Kevin Boyce
Concurrent gaps in the Late Devonian/Mississippian fossil records of insects and tetrapods (i.e. Romer's Gap) have been attributed to physiological suppression by low atmospheric pO2 Here, updated stable isotope inputs inform a reconstruction of Phanerozoic oxygen levels that contradicts the low oxygen hypothesis (and contradicts the purported role of oxygen in the evolution of gigantic insects during the late Palaeozoic), but reconciles isotope-based calculations with other proxies, like charcoal. Furthermore, statistical analysis demonstrates that the gap between the first Devonian insect and earliest diverse insect assemblages of the Pennsylvanian (Bashkirian Stage) requires no special explanation if insects were neither diverse nor abundant prior to the evolution of wings...
January 31, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29362999/abstracts-of-the-33rd-international-austrian-winter-symposium-zell-am-see-austria-24-27-january-2018
#13
K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, E J Teoh, D Bottomley, A Scarsbrook, H Payne, A Afaq, J Bomanji, N van As, S Chua, P Hoskin, A Chambers, G J Cook, V S Warbey, A Chau, P Ward, M P Miller, D J Stevens, L Wilson, F V Gleeson, K Scheidhauer, C Seidl, M Autenrieth, F Bruchertseifer, C Apostolidis, F Kurtz, T Horn, C Pfob, M Schwaiger, J Gschwend, C D'Alessandria, A Morgenstern, C Uprimny, A Kroiss, C Decristoforo, E von Guggenberg, B Nilica, W Horninger, I Virgolini, S Rasul, N Poetsch, A Woehrer, M Preusser, M Mitterhauser, W Wadsak, G Widhalm, M Mischkulnig, M Hacker, T Traub-Weidinger, C L Wright, K Binzel, E J Wuthrick, E D Miller, P Maniawski, J Zhang, M V Knopp, Sebastijan Rep, Marko Hocevar, Janja Vaupotic, Urban Zdesar, Katja Zaletel, Luka Lezaic, S Mairinger, Thomas Filip, M Sauberer, S Flunkert, T Wanek, J Stanek, N Okamura, O Langer, C Kuntner, M C Fornito, R Balzano, V Di Martino, S Cacciaguerra, G Russo, D Seifert, M Kleinova, A Cepa, J Ralis, P Hanc, O Lebeda, M Mosa, S Vandenberghe, E Mikhaylova, D Borys, V Viswanath, M Stockhoff, N Efthimiou, P Caribe, R Van Holen, J S Karp, K Binzel, J Zhang, C L Wright, P Maniawski, M V Knopp, P M Haller, C Farhan, E Piackova, B Jäger, P Knoll, A Kiss, B K Podesser, J Wojta, K Huber, S Mirzaei, A Traxl, K Komposch, Elisabeth Glitzner, T Wanek, S Mairinger, M Sibilia, O Langer, M C Fornito, M Russello, G Russo, R Balzano, S Sorko, H J Gallowitsch, S Kohlfuerst, S Matschnig, M Rieser, M Sorschag, P Lind, L Ležaič, S Rep, J Žibert, N Frelih, S Šuštar, K Binzel, A Adelaja, C L Wright, D Scharre, J Zhang, M V Knopp, R P Baum, T Langbein, A Singh, M Shahinfar, C Schuchardt, G F Volk, H R Kulkarni, M C Fornito, S Cacciaguerra, R Balzano, G V Di Martino, G Russo, W H Thomson, M Kudlacek, M Karik, C Farhan, H Rieger, W Pokieser, K Glaser, S Mirzaei, V Petz, C Tugendsam, W Buchinger, B Schmoll-Hauer, I P Schenk, K Rudolph, M Krebs, G Zettinig, V Zoufal, T Wanek, M Krohn, S Mairinger, J Stanek, M Sauberer, T Filip, J Pahnke, O Langer, F Weitzer, B Pernthaler, S Salamon, R Aigner, P Koranda, L Henzlová, M Kamínek, Mo Váchalová, P Bachleda, D Summer, J Garousi, M Oroujeni, B Mitran, K G Andersson, A Vorobyeva, J N Löfblom, A Orlova, V Tolmachev, C Decristoforo, P Kaeopookum, D Summer, T Orasch, B Lechner, M Petrik, Z Novy, C Rangger, H Haas, C Decristoforo
No abstract text is available yet for this article.
January 23, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29351280/a-generic-framework-for-individual-based-modelling-and-physical-biological-interaction
#14
Asbjørn Christensen, Patrizio Mariani, Mark R Payne
The increased availability of high-resolution ocean data globally has enabled more detailed analyses of physical-biological interactions and their consequences to the ecosystem. We present IBMlib, which is a versatile, portable and computationally effective framework for conducting Lagrangian simulations in the marine environment. The purpose of the framework is to handle complex individual-level biological models of organisms, combined with realistic 3D oceanographic model of physics and biogeochemistry describing the environment of the organisms without assumptions about spatial or temporal scales...
2018: PloS One
https://www.readbyqxmd.com/read/29346580/smoking-sex-and-non-small-cell-lung-cancer-steroid-hormone-receptors-in-tumor-tissue-s0424
#15
Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Gary R Zirpoli, Warren Davis, Rochelle Payne Ondracek, Wiam Bshara, Angela R Omilian, Robert Kratzke, Mary E Reid, Julian R Molina, Jill M Kolesar, Yuhchyau Chen, Robert M MacRae, James Moon, Philip Mack, David R Gandara, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone
Background: To what extent steroid hormones contribute to lung cancer in male and female never smokers and smokers is unclear. We examined expression of hormone receptors in lung tumors by sex and smoking. Methods: Patients with primary non-small cell lung cancer were recruited into an Intergroup study in the United States and Canada, led by SWOG (S0424). Tumors from 813 cases (450 women and 363 men) were assayed using immunohistochemistry for estrogen receptor (ER)-α, ER-β, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)...
January 13, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29342064/minimally-manipulated-bone-marrow-concentrate-compared-with-microfracture-treatment-of-full-thickness-chondral-defects-a-one-year-study-in-an-equine-model
#16
Constance R Chu, Lisa A Fortier, Ashley Williams, Karin A Payne, Taralyn M McCarrel, Megan E Bowers, Diego Jaramillo
BACKGROUND: Microfracture is commonly performed for cartilage repair but usually results in fibrocartilage. Microfracture augmented by autologous bone marrow concentrate (BMC) was previously shown to yield structurally superior cartilage repairs in an equine model compared with microfracture alone. The current study was performed to test the hypothesis that autologous BMC without concomitant microfracture improves cartilage repair compared with microfracture alone. METHODS: Autologous sternal bone marrow aspirate (BMA) was concentrated using a commercial system...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341718/search-for-invisible-decays-of-a-dark-photon-produced-in-e-e-collisions-at-babar
#17
J P Lees, V Poireau, V Tisserand, E Grauges, A Palano, G Eigen, D N Brown, M Derdzinski, A Giuffrida, Yu G Kolomensky, M Fritsch, H Koch, T Schroeder, C Hearty, T S Mattison, J A McKenna, R Y So, V E Blinov, A R Buzykaev, V P Druzhinin, V B Golubev, E A Kravchenko, A P Onuchin, S I Serednyakov, Yu I Skovpen, E P Solodov, K Yu Todyshev, A J Lankford, J W Gary, O Long, A M Eisner, W S Lockman, W Panduro Vazquez, D S Chao, C H Cheng, B Echenard, K T Flood, D G Hitlin, J Kim, T S Miyashita, P Ongmongkolkul, F C Porter, M Röhrken, Z Huard, B T Meadows, B G Pushpawela, M D Sokoloff, L Sun, J G Smith, S R Wagner, D Bernard, M Verderi, D Bettoni, C Bozzi, R Calabrese, G Cibinetto, E Fioravanti, I Garzia, E Luppi, V Santoro, A Calcaterra, R de Sangro, G Finocchiaro, S Martellotti, P Patteri, I M Peruzzi, M Piccolo, M Rotondo, A Zallo, S Passaggio, C Patrignani, H M Lacker, B Bhuyan, U Mallik, C Chen, J Cochran, S Prell, H Ahmed, A V Gritsan, N Arnaud, M Davier, F Le Diberder, A M Lutz, G Wormser, D J Lange, D M Wright, J P Coleman, E Gabathuler, D E Hutchcroft, D J Payne, C Touramanis, A J Bevan, F Di Lodovico, R Sacco, G Cowan, Sw Banerjee, D N Brown, C L Davis, A G Denig, W Gradl, K Griessinger, A Hafner, K R Schubert, R J Barlow, G D Lafferty, R Cenci, A Jawahery, D A Roberts, R Cowan, S H Robertson, B Dey, N Neri, F Palombo, R Cheaib, L Cremaldi, R Godang, D J Summers, P Taras, G De Nardo, C Sciacca, G Raven, C P Jessop, J M LoSecco, K Honscheid, R Kass, A Gaz, M Margoni, M Posocco, G Simi, F Simonetto, R Stroili, S Akar, E Ben-Haim, M Bomben, G R Bonneaud, G Calderini, J Chauveau, G Marchiori, J Ocariz, M Biasini, E Manoni, A Rossi, G Batignani, S Bettarini, M Carpinelli, G Casarosa, M Chrzaszcz, F Forti, M A Giorgi, A Lusiani, B Oberhof, E Paoloni, M Rama, G Rizzo, J J Walsh, A J S Smith, F Anulli, R Faccini, F Ferrarotto, F Ferroni, A Pilloni, G Piredda, C Bünger, S Dittrich, O Grünberg, M Heß, T Leddig, C Voß, R Waldi, T Adye, F F Wilson, S Emery, G Vasseur, D Aston, C Cartaro, M R Convery, J Dorfan, W Dunwoodie, M Ebert, R C Field, B G Fulsom, M T Graham, C Hast, W R Innes, P Kim, D W G S Leith, S Luitz, D B MacFarlane, D R Muller, H Neal, B N Ratcliff, A Roodman, M K Sullivan, J Va'vra, W J Wisniewski, M V Purohit, J R Wilson, A Randle-Conde, S J Sekula, M Bellis, P R Burchat, E M T Puccio, M S Alam, J A Ernst, R Gorodeisky, N Guttman, D R Peimer, A Soffer, S M Spanier, J L Ritchie, R F Schwitters, J M Izen, X C Lou, F Bianchi, F De Mori, A Filippi, D Gamba, L Lanceri, L Vitale, F Martinez-Vidal, A Oyanguren, J Albert, A Beaulieu, F U Bernlochner, G J King, R Kowalewski, T Lueck, I M Nugent, J M Roney, R J Sobie, N Tasneem, T J Gershon, P F Harrison, T E Latham, R Prepost, S L Wu
We search for single-photon events in 53  fb^{-1} of e^{+}e^{-} collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A^{'} through the process e^{+}e^{-}→γA^{'}; A^{'}→invisible. Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter. We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8  GeV...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29329280/status-of-hiv-epidemic-control-among-adolescent-girls-and-young-women-aged-15-24-years-seven-african-countries-2015-2017
#18
Kristin Brown, Daniel B Williams, Steve Kinchen, Suzue Saito, Elizabeth Radin, Hetal Patel, Andrea Low, Stephen Delgado, Owen Mugurungi, Godfrey Musuka, Beth A Tippett Barr, E Amaka Nwankwo-Igomu, Leala Ruangtragool, Avi J Hakim, Thokozani Kalua, Rose Nyirenda, Gertrude Chipungu, Andrew Auld, Evelyn Kim, Danielle Payne, Nellie Wadonda-Kabondo, Christine West, Elizabeth Brennan, Beth Deutsch, Anteneh Worku, Sasi Jonnalagadda, Lloyd B Mulenga, Kumbutso Dzekedzeke, Danielle T Barradas, Haotian Cai, Sundeep Gupta, Stanley Kamocha, Margaret A Riggs, Karampreet Sachathep, Wilford Kirungi, Joshua Musinguzi, Alex Opio, Sam Biraro, Elizabeth Bancroft, Jennifer Galbraith, Herbert Kiyingi, Mansoor Farahani, Wolfgang Hladik, Edith Nyangoma, Choice Ginindza, Zandile Masangane, Fortune Mhlanga, Zandile Mnisi, Pasipamire Munyaradzi, Amos Zwane, Sean Burke, Felix B Kayigamba, Harriet Nuwagaba-Biribonwoha, Ruben Sahabo, Trong T Ao, Chiara Draghi, Caroline Ryan, Neena M Philip, Fausta Mosha, Aroldia Mulokozi, Phausta Ntigiti, Angela A Ramadhani, Geoffrey R Somi, Cecilia Makafu, Veronicah Mugisha, Julius Zelothe, Kayla Lavilla, David W Lowrance, Rennatus Mdodo, Elizabeth Gummerson, Paul Stupp, Kyaw Thin, Koen Frederix, Stefania Davia, Amee M Schwitters, Stephen D McCracken, Yen T Duong, David Hoos, Bharat Parekh, Jessica E Justman, Andrew C Voetsch
In 2016, an estimated 1.5 million females aged 15-24 years were living with human immunodeficiency virus (HIV) infection in Eastern and Southern Africa, where the prevalence of HIV infection among adolescent girls and young women (3.4%) is more than double that for males in the same age range (1.6%) (1). Progress was assessed toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 2020 targets for adolescent girls and young women in sub-Saharan Africa (90% of those with HIV infection aware of their status, 90% of HIV-infected persons aware of their status on antiretroviral treatment [ART], and 90% of those on treatment virally suppressed [HIV viral load <1,000 HIV RNA copies/mL]) (2) using data from recent Population-based HIV Impact Assessment (PHIA) surveys in seven countries...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29304038/tumor-targeted-delivery-of-doxorubicin-in-malignant-peripheral-nerve-sheath-tumors
#19
A B Madhankumar, Oliver D Mrowczynski, Becky Slagle-Webb, Vagisha Ravi, Alexandre J Bourcier, Russell Payne, Kimberly S Harbaugh, Elias Rizk, James R Connor
Peripheral nerve sheath tumors are benign tumors that have the potential to transform into malignant peripheral nerve sheath tumors (MPNSTs). Interleukin-13 receptor alpha 2 (IL13Rα2) is a cancer associated receptor expressed in glioblastoma and other invasive cancers. We analyzed IL13Rα2 expression in several MPNST cell lines including the STS26T cell line, as well as in several peripheral nerve sheath tumors to utilize the IL13Rα2 receptor as a target for therapy. In our studies, we demonstrated the selective expression of IL13Rα2 in several peripheral nerve sheath tumors by immunohistochemistry (IHC) and immunoblots...
2018: PloS One
https://www.readbyqxmd.com/read/29303475/the-active-conceptual-framework-as-a-structural-equation-model
#20
Alden L Gross, Brennan R Payne, Ramon Casanova, Pega Davoudzadeh, Joseph M Dzierzewski, Sarah Farias, Tania Giovannetti, Edward H Ip, Michael Marsiske, George W Rebok, K Warner Schaie, Kelsey Thomas, Sherry Willis, Richard N Jones
Background/Study Context: Conceptual frameworks are analytic models at a high level of abstraction. Their operationalization can inform randomized trial design and sample size considerations. METHODS: The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) conceptual framework was empirically tested using structural equation modeling (N=2,802). ACTIVE was guided by a conceptual framework for cognitive training in which proximal cognitive abilities (memory, inductive reasoning, speed of processing) mediate treatment-related improvement in primary outcomes (everyday problem-solving, difficulty with activities of daily living, everyday speed, driving difficulty), which in turn lead to improved secondary outcomes (health-related quality of life, health service utilization, mobility)...
January 5, 2018: Experimental Aging Research
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