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R. Payne

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https://www.readbyqxmd.com/read/29044530/gingival-tissue-an-extrasynovial-source-of-malondialdehyde-acetaldehyde-adducts-citrullinated-and-carbamylated-proteins
#1
R Bright, G M Thiele, J Manavis, T R Mikuls, J B Payne, P M Bartold
BACKGROUND AND OBJECTIVE: Postranslational modification of proteins can lead to the production of autoantibodies and loss of immune tolerance. This process has been hypothesised to be a critical factor in the pathogenesis of rheumatoid arthritis. The objective of this study was to demonstrate that inflamed human gingival tissue provides an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins all of which are considered to be linked to the development of rheumatoid arthritis...
October 17, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29044134/impact-of-ocean-warming-on-sustainable-fisheries-management-informs-the-ecosystem-approach-to-fisheries
#2
N Serpetti, A R Baudron, M T Burrows, B L Payne, P Helaouët, P G Fernandes, J J Heymans
An integrated ecosystem model including fishing and the impact of rising temperatures, relative to species' thermal ranges, was used to assess the cumulative effect of future climate change and sustainable levels of fishing pressure on selected target species. Historically, important stocks of cod and whiting showed declining trends caused by high fisheries exploitation and strong top-down control by their main predators (grey seals and saithe). In a no-change climate scenario these stocks recovered under sustainable management scenarios due to the cumulative effect of reduced fishing and predation mortalities cascading through the food-web...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038095/factors-associated-with-engagement-with-a-web-based-lifestyle-intervention-following-provision-of-coronary-heart-disease-risk-mixed-methods-study
#3
Juliet A Usher-Smith, Laura R Winther, Guy S Shefer, Barbora Silarova, Rupert A Payne, Simon J Griffin
BACKGROUND: Web-based interventions provide the opportunity to combine the tailored approach of face-to-face interventions with the scalability and cost-effectiveness of public health interventions. This potential is often limited by low engagement. A number of studies have described the characteristics of individuals who engage more in Web-based interventions but few have explored the reasons for these variations. OBJECTIVE: We aimed to explore individual-level factors associated with different degrees of engagement with a Web-based behavior change intervention following provision of coronary heart disease (CHD) risk information, and the barriers and facilitators to engagement...
October 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29029933/highly-potent-and-selective-nav1-7-inhibitors-for-use-as-intravenous-agents-and-chemical-probes
#4
R Ian Storer, Andy Pike, Nigel A Swain, Aristos J Alexandrou, Bruce M Bechle, David C Blakemore, Alan D Brown, Neil A Castle, Matthew S Corbett, Neil J Flanagan, David Fengas, M Scott Johnson, Lyn H Jones, Brian E Marron, C Elizabeth Payne, David Printzenhoff, David J Rawson, Colin R Rose, Thomas Ryckmans, Jianmin Sun, Jonathan W Theile, Rubben Torella, Elaine Tseng, Joseph S Warmus
The discovery and selection of a highly potent and selective NaV1.7 inhibitor PF-06456384, designed specifically for intravenous infusion, is disclosed. Extensive in vitro pharmacology and ADME profiling followed by in vivo preclinical PK and efficacy model data are discussed. A proposed protein-ligand binding mode for this compound is also provided to rationalise the high levels of potency and selectivity over inhibition of related sodium channels. To further support the proposed binding mode, potent conjugates are described which illustrate the potential for development of chemical probes to enable further target evaluation...
November 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29023549/supraphysiologic-control-over-hiv-1-replication-mediated-by-cd8-t-cells-expressing-a-re-engineered-cd4-based-chimeric-antigen-receptor
#5
Rachel S Leibman, Max W Richardson, Christoph T Ellebrecht, Colby R Maldini, Joshua A Glover, Anthony J Secreto, Irina Kulikovskaya, Simon F Lacey, Sarah R Akkina, Yanjie Yi, Farida Shaheen, Jianbin Wang, Keith A Dufendach, Michael C Holmes, Ronald G Collman, Aimee S Payne, James L Riley
HIV is adept at avoiding naturally generated T cell responses; therefore, there is a need to develop HIV-specific T cells with greater potency for use in HIV cure strategies. Starting with a CD4-based chimeric antigen receptor (CAR) that was previously used without toxicity in clinical trials, we optimized the vector backbone, promoter, HIV targeting moiety, and transmembrane and signaling domains to determine which components augmented the ability of T cells to control HIV replication. This re-engineered CAR was at least 50-fold more potent in vitro at controlling HIV replication than the original CD4 CAR, or a TCR-based approach, and substantially better than broadly neutralizing antibody-based CARs...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28987909/event-related-brain-potentials-reveal-age-related-changes-in-parafoveal-foveal-integration-during-sentence-processing
#6
Brennan R Payne, Kara D Federmeier
Normative aging is associated with deficits in visual acuity and cognitive control that impact the allocation of visual attention, but little is known about how those changes affect information extraction and integration during visual language comprehension in older adulthood. In the current study, we used a visual hemi-field flanker RSVP paradigm with event-related brain potentials to study how older readers process fine-grained aspects of semantic expectancy in parafoveal and foveal vision. Stimuli consisted of high constraint sentences with expected, unexpected but plausible, or anomalous parafoveal target words, as well as low constraint sentences with neutral but expected target words...
October 4, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28986407/ferumoxytol-enhanced-magnetic-resonance-imaging-in-acute-myocarditis
#7
Colin G Stirrat, Shirjel R Alam, Thomas J MacGillivray, Calum D Gray, Marc R Dweck, Kevin Dibb, Nick Spath, John R Payne, Sanjay K Prasad, Roy S Gardner, Saeed Mirsadraee, Peter A Henriksen, Scott Ik Semple, David E Newby
OBJECTIVES: Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis. METHODS: Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months...
October 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28984195/md-miner-a-network-based-approach-for-personalized-drug-repositioning
#8
Haoyang Wu, Elise Miller, Denethi Wijegunawardana, Kelly Regan, Philip R O Payne, Fuhai Li
BACKGROUND: Due to advances in next generation sequencing technologies and corresponding reductions in cost, it is now attainable to investigate genome-wide gene expression and variants at a patient-level, so as to better understand and anticipate heterogeneous responses to therapy. Consequently, it is feasible to inform personalized drug treatment decisions using personal genomics data. However, these efforts are limited due to a lack of reliable computational approaches for predicting effective drugs for individual patients...
October 3, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28975658/current-and-novel-injectable-hydrogels-to-treat-focal-chondral-lesions-properties-and-applicability
#9
REVIEW
Cecilia Pascual-Garrido, Francisco Rodriguez-Fontan, Elizabeth A Aisenbrey, Karin A Payne, Jorge Chahla, Laurie R Goodrich, Stephanie J Bryant
Focal chondral lesions and early osteoarthritis (OA) are responsible for progressive joint pain and disability in millions of people worldwide, yet there is currently no surgical joint preservation treatment available to fully restore the long term functionality of cartilage. Limitations of current treatments for cartilage defects have prompted the field of cartilage tissue engineering, which seeks to integrate engineering and biological principles to promote the growth of new cartilage to replace damaged tissue...
October 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28973133/notice-of-retraction-and-replacement-wansink-b-just-dr-payne-cr-can-branding-improve-school-lunches-arch-pediatr-adolesc-med-2012-166-10-967-968-doi-10-1001-archpediatrics-2012-999
#10
Brian Wansink, David R Just, Collin R Payne
No abstract text is available yet for this article.
September 21, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28970059/structural-requirements-of-flavonoids-to-induce-heme-oxygenase-1-expression
#11
K D Croft, D Zhang, R Jiang, A Ayer, S Shengule, R J Payne, N C Ward, R Stocker
Population studies suggest cardiovascular health benefits of consuming fruits and vegetables rich in polyphenolic compounds such as flavonoids. We reported previously that the flavonoid quercetin protects arteries from oxidant-induced endothelial dysfunction and attenuates atherosclerosis in apolipoprotein E gene knockout mice, with induction of heme oxygenase-1 (Hmox1) playing a critical role. The present study investigated the structural requirements of flavonoids to induce Hmox1 in human aortic endothelial cells (HAEC)...
September 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28953102/emergency-department-utilization-by-native-american-children
#12
Heather G Zook, Anupam B Kharbanda, Susan E Puumala, Katherine A Burgess, Wyatt Pickner, Nathaniel R Payne
OBJECTIVES: The aims of this study were to determine differences in emergency department (ED) use by Native American (NA) children in rural and urban settings and identify factors associated with frequent ED visits. METHODS: This cross-sectional, cohort study examined visits to 6 EDs: 2 rural, 2 midsize urban, and 2 large urban EDs from June 2011 to May 2012. Univariate and multiple regression analyses were conducted. Frequent ED visitors had more than 4 visits in the study period...
September 25, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28926508/racial-ethnic-variation-in-emergency-department-care-for-children-with-asthma
#13
Heather G Zook, Nathaniel R Payne, Susan E Puumala, Katherine M Ziegler, Anupam B Kharbanda
OBJECTIVE: To assess the variation between racial/ethnic groups in emergency department (ED) treatment of asthma for pediatric patients. METHODS: This study was a cross-sectional analysis of pediatric (2-18 years) asthma visits among 6 EDs in the Upper Midwest between June 2011 and May 2012. We used mixed-effects logistic regression to assess the odds of receiving steroids, radiology tests, and returning to the ED within 30 days. We conducted a subanalysis of asthma visits where patients received at least 1 albuterol treatment in the ED...
September 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28901594/quantitative-evaluation-of-breast-cancer-response-to-neoadjuvant-chemotherapy-by-diffusion-tensor-imaging-initial-results
#14
Edna Furman-Haran, Noam Nissan, Verónica Ricart-Selma, Carmen Martinez-Rubio, Hadassa Degani, Julia Camps-Herrero
BACKGROUND: Diffusion tensor imaging (DTI) yields several parameters that have not been tested in response evaluation to neoadjuvant chemotherapy (NAC). PURPOSE: To evaluate and compare in reference to histopathology findings the ability of DTI and dynamic contrast-enhanced (DCE) MRI to monitor response to NAC. STUDY TYPE: Retrospective. POPULATION: Twenty patients treated with neoadjuvant chemotherapy. FIELD STRENGTH/SEQUENCE: 1...
September 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28890184/evaluation-of-the-tumor-response-after-neoadjuvant-chemotherapy-in-breast-cancer-patients-correlation-between-dynamic-contrast-enhanced-magnetic-resonance-imaging-and-pathologic-tumor-cellularity
#15
Woo Jung Choi, Won Kyung Kim, Hee Jung Shin, Joo Hee Cha, Eun Young Chae, Hak Hee Kim
BACKGROUND: We evaluated the tumor response after neoadjuvant chemotherapy (NAC) in breast cancer patients using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging parameters assessed using a commercially available computer-aided system. We also analyzed their correlation with pathologic tumor cellularity. MATERIALS AND METHODS: We retrospectively reviewed the data from 130 patients with breast cancer who had undergone NAC followed by surgery from January to October 2013...
August 18, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28881385/expansion-and-further-delineation-of-the-setd5-phenotype-leading-to-global-developmental-delay-variable-dysmorphic-features-and-reduced-penetrance
#16
Z Powis, K D Farwell Hagman, C Mroske, K McWalter, J S Cohen, R Colombo, A Serretti, A Fatemi, K L David, J Reynolds, L D Immken, H Nagakura, C Cunniff, K Payne, T Barbaro-Dieber, K W Gripp, L Baker, T Stamper, K A Aleck, E S Jordan, J Hersh, J Burton, I M Wentzensen, M J Guillen Sacoto, R Willaert, M T Cho, I Petrik, R Huether, S Tang
Diagnostic exome sequencing (DES) has aided delineation of the phenotypic spectrum of rare genetic etiologies of intellectual disability (ID). A SETD5 phenotype of ID and dysmorphic features has been previously described in relation to patients with 3p25.3 deletions and in a few individuals with de novo sequence alterations. Herein, we present additional patients with pathogenic SETD5 sequence alterations. The majority of patients in this cohort and previously reported have developmental delay, behavioral/psychiatric issues, and variable hand and skeletal abnormalities...
September 7, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28868322/viability-and-tissue-quality-of-cartilage-flaps-from-patients-with-femoroacetabular-hip-impingement-a-matched-control-comparison
#17
Francisco Rodriguez-Fontan, Karin A Payne, Jorge Chahla, Omer Mei-Dan, Abigail Richards, Soshi Uchida, Cecilia Pascual-Garrido
BACKGROUND: Chondrolabral damage is commonly observed in patients with cam-type femoroacetabular impingement (FAI). Chondral flap reattachment has recently been proposed as a possible preservation technique. PURPOSE/HYPOTHESIS: The purpose of this study was to determine the viability and tissue quality of chondral flaps from patients with FAI at the time of arthroscopy. It was hypothesized that chondral flaps from patients with cam lesions of the hip would exhibit less viability and greater tissue degeneration than would those of a matched control group...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28864937/meta-analysis-of-randomised-trials-comparing-the-use-of-prophylactic-mesh-to-standard-midline-closure-in-the-reduction-of-incisional-herniae
#18
REVIEW
R Payne, J Aldwinckle, S Ward
Purpose Incisional hernia (IH) is common complication following laparotomy. Research suggests that the use of a prophylactic mesh can reduce the rate of IH. We performed an updated meta-analysis to better understand the evidence regarding prevention of IH using prophylactic mesh. METHODS: PubMed, clinictrials.gov.uk, and the Cochrane database were searched for randomised controlled trials comparing closure of the abdomen after laparotomy using a prophylactic mesh with suture closure. A meta-analysis was then performed...
September 1, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28860192/improving-the-thermal-stability-of-cellobiohydrolase-cel7a-from-hypocrea-jecorina-by-directed-evolution
#19
Frits Goedegebuur, Lydia Dankmeyer, Peter Gualfetti, Saeid Karkehabadi, Henrik Hansson, Suvamay Jana, Vicky Huynh, Bradley R Kelemen, Paulien Kruithof, Edmund A Larenas, Pauline J M Teunissen, Jerry Ståhlberg, Christina M Payne, Colin Mitchinson, Mats Sandgren
Secreted mixtures of Hypocrea jecorina cellulases are able to efficiently degrade cellulosic biomass to fermentable sugars at large, commercially relevant scales. H. jecorina Cel7A, cellobiohydrolase I, from glycoside hydrolase family 7, is the workhorse enzyme of the process. However, the thermal stability of Cel7A limits its use to processes where temperatures are no higher than 50°C. Enhanced thermal stability is desirable to enable use of higher process temperatures and improve the economic feasibility of industrial biomass conversion...
August 31, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28843169/the-low-single-nucleotide-polymorphism-heritability-of-plasma-and-saliva-cortisol-levels
#20
Alexander Neumann, Nese Direk, Andrew A Crawford, Saira Mirza, Hieab Adams, Jennifer Bolton, Caroline Hayward, David P Strachan, Erin K Payne, Jennifer A Smith, Yuri Milaneschi, Brenda Penninx, Jouke J Hottenga, Eco de Geus, Albertine J Oldehinkel, Peter J van der Most, Yolanda de Rijke, Brian R Walker, Henning Tiemeier
Cortisol is an important stress hormone affected by a variety of biological and environmental factors, such as the circadian rhythm, exercise and psychological stress. Cortisol is mostly measured using blood or saliva samples. A number of genetic variants have been found to contribute to cortisol levels with these methods. While the effects of several specific single genetic variants is known, the joint genome-wide contribution to cortisol levels is unclear. Our aim was to estimate the amount of cortisol variance explained by common single nucleotide polymorphisms, i...
August 12, 2017: Psychoneuroendocrinology
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