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"Neurological recovery"

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https://www.readbyqxmd.com/read/28315960/intravenous-thrombolysis-for-ischemic-stroke-in-the-golden-hour-propensity-matched-analysis-from-the-sits-east-registry
#1
Georgios Tsivgoulis, Aristeidis H Katsanos, Pavla Kadlecová, Anna Czlonkowska, Adam Kobayashi, Miroslav Brozman, Viktor Švigelj, Laszlo Csiba, Klara Fekete, Janika Kõrv, Vida Demarin, Aleksandras Vilionskis, Dalius Jatuzis, Yakup Krespi, Chrissoula Liantinioti, Sotirios Giannopoulos, Robert Mikulik
As there are scarce data regarding the outcomes of acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) within 60 min from symptom onset ("golden hour"), we sought to compare outcomes between AIS patients treated within [GH(+)] and outside [GH(-)] the "golden hour" by analyzing propensity score matched data from the SITS-EAST registry. Clinical recovery (CR) at 2 and 24 h was defined as a reduction of ≥10 points on NIHSS-score or a total NIHSS-score of ≤3 at 2 and 24 h, respectively...
March 18, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28306544/acute-ischemic-stroke-mimicking-subarachnoid-hemorrhage-after-coronary-angioplasty
#2
Ana Pršić, Tomislav Šipić, Krešimr Štambuk, Hrvoje Budinčević
Use of non-ionic contrast media (CM) in coronary arteriography has been reported to cause transient cortical blindness, confusion, amnesia and very rare focal deficits. We report a 69-year old patient with stabile angina pectoris who underwent coronary angioplasty with stent placement due to in-stent thrombosis of the right coronary artery who developed stroke symptoms with radiological suspicion of subarachnoid hemorrhage. No vascular malformations were detected on CT cerebral angiography. Dual antiplatelet treatment was continued...
March 16, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28300747/pathophysiology-of-dilatation-of-pupils-due-to-scorpion-and-snake-envenomation-and-its-therapeutic-value-clinical-observations
#3
Himmatrao S Bawaskar, Parag H Bawaskar, Pramodini H Bawaskar
Dilated nonreacting pupils are routinely taken as a sign of irreversible brain damage. Alpha-receptor stimulation (scorpion sting) and presynaptic acetylcholine receptor blocker (krait bite) may result in dilation of pupils without involvement of the brain. This study was aimed to clinically evaluate the response of pupils in scorpion sting and krait bite. Victims of scorpion sting and krait bite were chosen from Raigad district. Scorpion sting and krait bite cases were admitted to hospital and were clinically evaluated in detail regarding neurological manifestations...
January 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28300551/role-of-caveolin-1-vascular-endothelial-growth-factor-pathway-in-basic-fibroblast-growth-factor-induced-angiogenesis-and-neurogenesis-after-treadmill-training-following-focal-cerebral-ischemia-in-rats
#4
Qiongyi Pang, Huimei Zhang, Zhenzhen Chen, Yudan Wu, Min Yidian Bai Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen
Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats...
March 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28291547/remote-cerebellar-haemorrhage-after-placement-of-an-external-ventricular-drainage-for-acute-hydrocephalus-a-case-report
#5
I Caldeira, J Lavrador, G Basílio, R Sousa, S Reimão
INTRODUCTION: Remote cerebellar haemorrhage (RCH) is a rare complication following a craniotomy. This generally benign phenomenon is an identifiable complication of supratentorial craniotomies and should not be mistaken with other pathologies. The most common presenting symptom is a decrease in the level of consciousness but in some cases the RCH may be asymptomatic and accidentally discovered in follow-up CT scans. CASE REPORT: A 70-year-old man was admitted to our emergency department with sudden mental status deterioration...
March 10, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28288922/clinical-features-management-and-prognostic-factors-of-spontaneous-epidural-spinal-hematoma-analysis-of-24-cases
#6
Mengmeng Wang, Peizhi Zhou, Shu Jiang
BACKGROUND: Spontaneous spinal epidural hematoma (SSEH) is a rare neurosurgical emergency. It presents as acute spinal cord compression and usually requires surgical decompression. The patients who will benefit most from decompression surgery are unknown and the factors associated with prognosis remain controversial. The purpose of our study was to identify the clinical features, treatments, and main factors related to the prognosis of SSEH. METHODS: We reviewed the records of 24 patients treated for SSEH from September 2010 to January 2016 at West China Hospital...
March 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28286844/early-versus-late-spinal-decompression-surgery-in-treatment-of-traumatic-spinal-cord-injuries-a-systematic-review-and-meta-analysis
#7
REVIEW
Mahmoud Yousefifard, Vafa Rahimi-Movaghar, Masoud Baikpour, Parisa Ghelichkhani, Mostafa Hosseini, AliMoghadas Jafari, Heidar Aziznejad, Abbas Tafakhori
INTRODUCTION: Despite the vast number of surveys, no consensus has been reached on the optimum timing of spinal decompression surgery. This systematic review and meta-analysis aimed to compare the effects of early and latespinal decompression surgery on neurologic improvement and post-surgical complications in patients with traumatic spinal cord injuries. METHODS: Two independent reviewers carried out an extended search in electronic databases. Data of neurological outcome and post-surgery complication were extracted...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28276985/a-targeted-proteomics-analysis-of-cerebrospinal-fluid-after-acute-human-spinal-cord-injury
#8
Femke Streijger, Michael Skinnider, Jason C Rogalski, Robert Balshaw, Casey P Shannon, Anna Prudova, Lise M Belanger, Leanna Ritchie, Angela Tsang, Sean Christie, Stefan Parent, Jean-Marc Mac-Thiong, Christopher Bailey, Jennifer Urquhart, Tamir Ailon, Scott J Paquette, Michael C Boyd, John Street, Charles G Fisher, Marcel F Dvorak, Christoph H Borchers, Leonard J Foster, Brian K Kwon
Efforts to validate novel therapies in acute clinical trials for spinal cord injury (SCI) are impeded by the lack of objective quantitative measures that reflect injury severity and accurately predict neurologic recovery. Therefore, a strong rationale exists to establish neurochemical biomarkers that objectively quantify injury severity and predict outcome. Here, we conducted a targeted proteomics analysis of cerebrospinal fluid (CSF) samples derived from 29 acute SCI patients (AIS A, B, or C) acquired at 24, 48, and 72 hours post-injury...
March 9, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28275048/brain-machine-interfaces-from-basic-science-to-neuroprostheses-and-neurorehabilitation
#9
REVIEW
Mikhail A Lebedev, Miguel A L Nicolelis
Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between living brains and artificial actuators. Although theoretical propositions and some proof of concept experiments on directly linking the brains with machines date back to the early 1960s, BMI research only took off in earnest at the end of the 1990s, when this approach became intimately linked to new neurophysiological methods for sampling large-scale brain activity...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28268688/dihydrocapsaicin-induced-hypothermia-after-asphyxiai-cardiac-arrest-in-rats
#10
Junyun He, Leanne Young, Xiaofeng Jia
Cardiac arrest (CA) is one of the leading causes of mortality and morbidity in the world. Fast, reversible and controllable pharmaceutical-induced hypothermia (PIH) is strongly desired to treat ischemia-reperfusion brain injury. Dihydrocapsaicin (DHC), an agonist of transient receptor potential vanilloid type 1 cation channel (TRPV1), is an emerging candidate for PIH. Its capability to lower body temperature has been validated in both healthy and stroke animal models. However, DHC has shown cardiovascular effects and its safety and feasibility in a CA model has not been tested...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266950/postoperative-analgesia-after-wound-infiltration-with-tramadol-and-dexmedetomidine-as-an-adjuvant-to-ropivacaine-for-lumbar-discectomies-a-randomized-controlled-clinical-trial
#11
Saikat Mitra, Shobha Purohit, Mamta Sharma
INTRODUCTION: Crippling postoperative pain linked with lumbar discectomies not only shackles patient's normal daily activities but also lengthens their hospital stay. So, allaying postoperative pain in these patients has become a substantive component in neuroanesthesia to expedite neurological recovery. Wound infiltration with local anesthetics is widely used to optimize postoperative pain. Different adjuvants like dexmedetomidine and tramadol when added to local anesthetics prolongs postoperative analgesia...
March 6, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28264471/epigenetics-in-stroke-recovery
#12
REVIEW
Haifa Kassis, Amjad Shehadah, Michael Chopp, Zheng Gang Zhang
While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke...
February 27, 2017: Genes
https://www.readbyqxmd.com/read/28253289/comparison-of-harmonic-blade-versus-traditional-approach-in-canine-patients-undergoing-spinal-decompressive-surgery-for-naturally-occurring-thoracolumbar-disk-extrusion
#13
Bianca F Hettlich, Laurie Cook, Cheryl London, Geoffrey T Fosgate
OBJECTIVES: To assess feasibility of the harmonic Osteovue blade (HOB) for use in the soft tissue approach for dogs undergoing hemilaminectomy and to compare outcomes between dogs undergoing HOB or traditional approach (TRAD). METHODS: A prospective randomized clinical trial was performed using 20 client-owned dogs with thoracolumbar intervertebral disk extrusion requiring hemilaminectomy. Dogs were randomly assigned to HOB or TRAD. Neurologic function and pain scores were assessed pre-operatively...
2017: PloS One
https://www.readbyqxmd.com/read/28250732/emerging-potential-of-exosomes-for-treatment-of-traumatic-brain-injury
#14
REVIEW
Ye Xiong, Asim Mahmood, Michael Chopp
Traumatic brain injury (TBI) is one of the major causes of death and disability worldwide. No effective treatment has been identified from clinical trials. Compelling evidence exists that treatment with mesenchymal stem cells (MSCs) exerts a substantial therapeutic effect after experimental brain injury. In addition to their soluble factors, therapeutic effects of MSCs may be attributed to their generation and release of exosomes. Exosomes are endosomal origin small-membrane nano-sized vesicles generated by almost all cell types...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28250249/one-stage-extreme-lateral-interbody-fusion-and-percutaneous-pedicle-screw-fixation-in-lumbar-spine-tuberculosis
#15
Q-Y Wang, M-G Huang, D-Q Ou, Y-C Xu, J-W Dong, H-D Yin, W Chen, L-M Rong
OBJECTIVES: We explored the efficacy of minimal invasive surgery including one-stage debridement and intervertebral fusion through extreme lateral channel (XLIF) combined with lateral or percutaneous posterior pedicle screw fixation for the treatment of lumbar spine tuberculosis. METHODS: Twenty two patients with lumbar tuberculosis who underwent surgery with XLIF technique and internal fixation were included in the study. Their data about operative time, intraoperative blood loss, bone fusion, kyphosis correction, and clinical recovery were retrospectively collected and analyzed...
March 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/28247075/cervical-facet-dislocations-in-the-adolescent-population-a-report-of-21-cases-at-a-level-1-trauma-center-from-2004-to-2014
#16
Alireza K Anissipour, Julie Agel, Carlo Bellabarba, Richard J Bransford
PURPOSE: The purpose of this study was to present a series of adolescent patients with cervical facet dislocations to identify the mechanism of injury, severity of neurological injury and rate of neurological recovery. METHODS: Between 2004 and 2014, a retrospective review at a level I trauma center identified patients with unilateral or bilateral dislocated facet(s). Demographic data, initial neurological exams, surgical data, radiographic findings, and follow-up records were reviewed...
February 28, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28245686/analyzing-cost-effectiveness-of-ulnar-and-median-nerve-transfers-to-regain-forearm-flexion
#17
Arvin R Wali, Charlie C Park, Justin M Brown, Ross Mandeville
OBJECTIVE Peripheral nerve transfers to regain elbow flexion via the ulnar nerve (Oberlin nerve transfer) and median nerves are surgical options that benefit patients. Prior studies have assessed the comparative effectiveness of ulnar and median nerve transfers for upper trunk brachial plexus injury, yet no study has examined the cost-effectiveness of this surgery to improve quality-adjusted life years (QALYs). The authors present a cost-effectiveness model of the Oberlin nerve transfer and median nerve transfer to restore elbow flexion in the adult population with upper brachial plexus injury...
March 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28243366/evaluation-of-outcome-of-transpedicular-decompression-and-instrumented-fusion-in-thoracic-and-thoracolumbar-tuberculosis
#18
Akshay Jain, R K Jain, Vivek Kiyawat
STUDY DESIGN: Retrospective analysis. PURPOSE: We evaluated the functional, neurological, and radiological outcome in patients with thoracic and thoracolumbar tuberculosis operated through the transpedicular approach. OVERVIEW OF LITERATURE: For surgical treatment of thoracic and thoracolumbar tuberculosis, the anterior approach has been the most popular because it allows direct access to the infected tissue, thereby providing good decompression...
February 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28243312/acupuncture-improved-neurological-recovery-after-traumatic-brain-injury-by-activating-bdnf-trkb-pathway
#19
Xiaohong Li, Chong Chen, Xiping Yang, Jingjing Wang, Ming-Liang Zhao, Hongtao Sun, Sai Zhang, Yue Tu
How to promote neural repair following traumatic brain injury (TBI) has long been an intractable problem. Although acupuncture has been demonstrated to facilitate the neurological recovery, the underlying mechanism is elusive. Brain-derived neurotrophic factor (BDNF) exerts substantial protective effects for neurological disorders. In this study, we found that the level of BDNF and tropomyosin receptor kinase B (TrkB) was elevated spontaneously after TBI and reached up to the peak at 12 h. Nevertheless, this enhancement is quickly declined to the normal at 48 h...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28242586/feasibility-and-safety-of-direct-catheter-based-thrombectomy-in-the-treatment-of-acute-ischemic-stroke-cooperation-of-cardiologists-neurologists-and-radiologists-prospective-registry-prague-16
#20
Petr Widimsky, Boris Koznar, Tomas Peisker, Peter Vasko, Filip Rohac, Jana Vavrova, Josef Kroupa, Ivana Stetkarova
AIMS: The aim of this study was to evaluate the role of direct catheter-based thrombectomy (d-CBT, without thrombolysis) and the feasibility and safety of d-CBT performed in an interventional cardiology center. METHODS AND PATIENTS: Single center, prospective observational registry based on the prespecified protocol included 3 months follow-up. The decision to perform acute stroke intervention was done by a neurologist based on the clinical and imaging findings...
February 28, 2017: EuroIntervention
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