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https://www.readbyqxmd.com/read/27919862/spinal-cord-injury-assessing-tolerability-and-use-of-combined-rehabilitation-and-neuroaid-saturn-study-protocol-of-an-exploratory-study-in-assessing-the-safety-and-efficacy-of-neuroaid-amongst-people-who-sustain-severe-spinal-cord-injury
#1
Ramesh Kumar, Ohnmar Htwe, Azmi Baharudin, Mohammad Hisam Ariffin, Shaharuddin Abdul Rhani, Kamalnizat Ibrahim, Aishah Rustam, Robert Gan
BACKGROUND: Spinal cord injury (SCI) is a devastating condition with limited therapeutic options despite decades of research. Current treatment options include use of steroids, surgery, and rehabilitation. Nevertheless, many patients with SCI remain disabled. MLC601 (NeuroAiD), a combination of natural products, has been shown to be safe and to aid neurological recovery after brain injuries and may have a potential role in improving recovery after SCI. OBJECTIVE: The aim of this study is to evaluate the safety and efficacy of NeuroAiD amongst people who sustain SCI in the study setting...
December 5, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27919270/delayed-hyperbaric-oxygen-therapy-for-air-emboli-after-open-heart-surgery-case-report-and-review-of-a-success-story
#2
Eva Niyibizi, Guillaume Elyes Kembi, Claude Lae, Rodrigue Pignel, Tornike Sologashvili
BACKGROUND: The current case describes a rare diagnosis of iatrogenic air emboli after elective cardiopulmonary bypass that was successfully treated with delayed hyperbaric oxygen therapy, with good clinical evolution in spite of rare complications. CASE PRESENTATION: A 35 years old male was admitted to the intensive care unit (ICU) for post-operative management after being placed on cardiopulmonary bypass (CPB) for an elective ventricular septal defect closure and aortic valvuloplasty...
December 5, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27906641/time-to-cooling-is-associated-with-resuscitation-outcomes
#3
Robert B Schock, Andreas Janata, W Frank Peacock, Nathan S Deal, Sarathi Kalra, Fritz Sterz
Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling...
December 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27894943/acquired-chiari-malformation-and-syringomyelia-secondary-to-space-occupying-lesions-a-systematic-review
#4
REVIEW
Justin Wang, Naif M Alotaibi, Nardin Samuel, George M Ibrahim, Aria Fallah, Michael D Cusimano
BACKGROUND: Acquired Chiari malformations (ACM) and associated syringomyelia secondary to space-occupying lesions can cause neurological deficits independent of or in combination with the offending mass. Although type I CM are traditionally treated with posterior fossa decompression, optimal surgical management of ACM and associated syringomyelia remains unclear. The purpose of this study is to review the current literature surrounding the management of ACM. METHODS: A systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
November 25, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27894562/todd-s-paresis-in-acute-mild-head-trauma
#5
Alan Cowley, David Wright, Thomas Breen, Richard Lyon
We present the case of an adult male who sustained Todd's paresis after a traumatically induced seizure in a patient with an isolated facial injury. The precipitating event was head trauma from a golf club. The patient had no previous history of seizures and went on to make a complete neurologic recovery with no cerebral pathology noted. A literature review suggests that Todd's paresis after trauma is very rare as opposed to occurring in the medical or long-term brain injury settings. Although the authors acknowledge that it may occur in trauma, the awareness within the prehospital setting is sufficiently rare for this case report to be of interest to prehospital clinicians; it is important prehospital clinicians are aware of this condition...
November 2016: Air Medical Journal
https://www.readbyqxmd.com/read/27891411/unusual-presentation-of-radial-nerve-entrapment-with-lateral-humeral-condyle-fracture-a-case-report
#6
Manoharan Muthulingam, Swagat Mahapatra
Lateral humeral condyle fracture is the second most common fracture around the elbow in pediatric age group. Acute neurological deficit as a consequence of nerve injury associated with lateral humeral condyle fractures is very uncommon. We report a rare presentation of a case of lateral humeral condyle fracture in a 13-year-old boy with acute radial nerve palsy. Patient was operated through a modified anterolateral approach to the elbow with, exploration of the radial nerve and internal fixation of the fracture...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27888142/profiling-and-identification-of-new-proteins-involved-in-brain-ischemia-using-maldi-imaging-mass-spectrometry
#7
Víctor Llombart, Sebastián Alejandro Trejo, Sílvia Bronsoms, Anna Morancho, Ma Feifei, Júlia Faura, Teresa García-Berrocoso, Alba Simats, Anna Rosell, Francesc Canals, Mar Hernández-Guillamón, Joan Montaner
: The identification of proteins involved in brain ischemia might allow the discovery of putative biomarkers or therapeutic targets for ischemic stroke. Our aim is to study the distribution of proteins within mouse brain after an ischemic insult using MALDI imaging-mass-spectrometry and to identify relevant proteins involved in brain damage. We occluded the middle cerebral artery of C57BL/6J mice. Brain slices were analyzed by MALDI-TOF and infarct (IC) and contralateral (CL) regions were compared using ClinProTools...
November 22, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27886882/pharmacologic-management-of-acute-spinal-cord-injury
#8
REVIEW
Michael Karsy, Gregory Hawryluk
Spinal cord injury is a serious global public health problem that often leaves patients with devastating permanent disabilities. Although advances in supportive care have improved outcome in recent decades, there remains great need for a safe and efficacious medical treatment that improves neurologic outcome. This article reviews pharmacologic treatments evaluated or in the process of development in humans. Cellular transplantation strategies are briefly reviewed especially where they have been evaluated with pharmacologic treatments...
January 2017: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/27871588/novel-resuscitation-devices-facilitate-complete-neurologic-recovery-after-prolonged-cardiac-arrest-in-postanesthesia-care-unit
#9
Elif C Cingi, Luke A McMahon, Richard C Prielipp
Cardiac arrest in the perioperative period is associated with significant morbidity and mortality. Novel resuscitation devices may afford patients improved survival and limit neurologic injury. We report a case of cardiac arrest in the postanesthesia care unit that required an extensive period of cardiopulmonary resuscitation assisted by the ResQPOD impedance threshold device to optimize coronary perfusion and a LUCAS chest compression system to maintain optimal cardiopulmonary resuscitation while transporting the patient to the cardiac catheterization laboratory...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27863083/promotion-of-neurological-recovery-in-rat-spinal-cord-injury-by-mesenchymal-stem-cells-loaded-on-nerve-guided-collagen-scaffold-through-increasing-alternatively-activated-macrophage-polarization
#10
Zhan Peng, Wei Gao, Bing Yue, Jie Jiang, Yong Gu, Jianwu Dai, Liang Chen, Qin Shi
Mesenchymal stem cells(MSCs)characterized by multi-differentiation potent and immunoregulatory have been used in the treatment of spinal cord injury (SCI), but the direct transplantation may limit its effectiveness due to quick diffusion. In addition, the role of macrophages in healing is being increasingly recognized because of the ability to polarize into pro- and anti-inflammatory phenotypes. In the present study, we developed the nerve-guide collagen scaffold (CS) and rat MSCs. After CS was confirmed to minimize MSCs distribution in vivo by the positron emission tomography (PET) imaging, the repair capacity of combined implantation of CS and MSCs and the effect on classically activated macrophage (M1)/alternatively activated macrophage (M2) polarization was assessed in a hemisected SCI rat model...
November 15, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27862629/secreted-ectodomain-of-sialic-acid-binding-ig-like-lectin-9-and-mcp-1-synergistically-regenerate-transected-rat-peripheral-nerves-by-altering-macrophage-polarity
#11
Fumiya Kano, Kohki Matsubara, Minoru Ueda, Hideharu Hibi, Akihito Yamamoto
Peripheral nerves exhibit remarkable self-repairing reparative activity after a simple crush or cut injury. However, the neuronal transection involving a nerve gap overwhelms their repairing activity and causes persistent paralysis. Here, we show that an implantation of the serum-free conditioned medium from stem cells from human exfoliated deciduous teeth (SHED-CM) immersed in a collagen sponge into the nerve gap formed by rat facial nerves transection restored the neurological function. In contrast, SHED-CM specifically depleted of a set of anti-inflammatory M2 macrophage inducers, Monocyte monocyte chemoattractant protein-1 (MCP-1) and the secreted ectodomain of sialic acid-binding Ig-like lectin-9 (sSiglec-9) lost the ability to restore neurological function in this model...
November 10, 2016: Stem Cells
https://www.readbyqxmd.com/read/27861407/long-term-training-with-a-brain-machine-interface-based-gait-protocol-induces-partial-neurological-recovery-in-paraplegic-patients
#12
Jingyi Liu, Muhammad Abd-El-Barr, John H Chi
No abstract text is available yet for this article.
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27855720/pharmacological-interventions-for-agitation-in-patients-with-traumatic-brain-injury-protocol-for-a-systematic-review-and-meta-analysis
#13
David R Williamson, Anne Julie Frenette, Lisa Burry, Marc M Perreault, Emmanuel Charbonney, François Lamontagne, Marie-Julie Potvin, Jean-François Giguère, Sangeeta Mehta, Francis Bernard
BACKGROUND: Traumatic brain injury (TBI) is a worldwide leading cause of mortality and disability. Among TBI complications, agitation is a frequent behavioural problem. Agitation causes potential harm to patients and caregivers, interferes with treatments, leads to unnecessary chemical and physical restraints, increases hospital length of stay, delays rehabilitation, and impedes functional independence. Pharmacological treatments are often considered for agitation management following TBI...
November 17, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27853449/peripheral-inflammatory-markers-and-antioxidant-response-during-the-post-acute-and-chronic-phase-after-severe-traumatic-brain-injury
#14
Federico Licastro, Silvana Hrelia, Elisa Porcellini, Marco Malaguti, Cristina Di Stefano, Cristina Angeloni, Ilaria Carbone, Laura Simoncini, Roberto Piperno
Traumatic brain injury (TBI) is a mechanical insult to the brain caused by external forces and associated with inflammation and oxidative stress. The patients may show different profiles of neurological recovery and a combination of oxidative damage and inflammatory processes can affect their courses. It is known that an overexpression of cytokines can be seen in peripheral blood in the early hours/days after the injury, but little is known about the weeks and months encompassing the post-acute and chronic phases...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27849964/323-neurologic-recovery-among-nonsurvivors-after-cardiac-arrest
#15
Fabio Silvio Taccone, Christian Storm, Alain Cariou, Hans Friberg, Mauro Oddo, Jacques Creteur, Cornelia Hoedemaekers, Janneke Horn
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847808/the-role-of-targeted-temperature-management-in-adult-patients-resuscitated-from-nonshockable-cardiac-arrests-an-updated-systematic-review-and-meta-analysis
#16
REVIEW
Lijuan Song, Liang Wei, Lei Zhang, Yubao Lu, Kaifa Wang, Yongqin Li
Routine targeted temperature management is recommended for comatose adult patients with return of spontaneous circulation after cardiac arrest. However, the role of targeted temperature management in patients resuscitated from nonshockable cardiac arrests remains uncertain. We conducted an updated systematic review and meta-analysis to evaluate the effects of targeted temperature management in this population. Medline, EMBASE, and Cochrane databases were systematically reviewed for studies published between January 2005 and March 2016, in which targeted temperature management was compared with standard care or normothermia for adult patients resuscitated from nonshockable cardiac arrests...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27845852/platelet-rich-plasma-a-source-of-autologous-growth-factors-and-biomimetic-scaffold-for-peripheral-nerve-regeneration
#17
Mikel Sánchez, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive, Sabino Padilla
In mammals, axons of injured peripheral nerves (PNI) can and do regenerate, but often the functional recovery is incomplete or suboptimal. In recent years, in vivo tissue engineering approaches through molecular intervention and scaffolding are offering promising outcomes. Evidence is accumulating in both preclinical and clinical settings indicating that platelet rich plasma (PRP) and fibrin scaffolds obtained from this technology hold an important adjuvant therapeutic potential. Areas covered: This review addresses current molecular and cellular data in intrinsic nerve repair processes and describes different strategies to harness and enhance these processes by using biochemical and biomechanical cues...
November 15, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27831991/outcomes-of-surgical-treatment-for-thoracic-myelopathy-a-single-institutional-study-of-73-patients
#18
Eijiro Onishi, Tadashi Yasuda, Hiroshi Yamamoto, Koichi Iwaki, Satoshi Ota
STUDY DESIGN: Retrospective study. OBJECTIVE: The aim was to investigate the clinical outcomes in patients with thoracic myelopathy in a single institution and to identify prognostic factors for poor outcomes. SUMMARY OF BACKGROUND DATA: Because of the rarity of thoracic myelopathy, a few studies have analyzed a large number of clinical results for patients with thoracic myelopathy treated in a single institution. METHODS: Seventy-one patients who underwent surgical treatment for thoracic myelopathy between 2000 and 2011 in a single institution were included in this analysis...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27816529/the-influence-of-comorbidity-on-survival-and-long-term-outcomes-after-out-of-hospital-cardiac-arrest
#19
Emily Andrew, Ziad Nehme, Stephen Bernard, Karen Smith
INTRODUCTION: Comorbid conditions have been associated with morbidity, functional status and quality of life for patients with a wide range of diseases. Previous studies have attempted to elucidate the influence of pre-arrest comorbidities on survival and neurological recovery following out-of-hospital cardiac arrest (OHCA), however the findings are conflicting. METHODS: Baseline comorbidities recorded within prehospital patient care records were linked with baseline and 12-month follow-up data from the Victorian Ambulance Cardiac Arrest Registry for adult (≥16 years) non-traumatic OHCA patients...
November 2, 2016: Resuscitation
https://www.readbyqxmd.com/read/27807296/guillain-barr%C3%A3-syndrome-associated-with-zika-virus-infection-in-a-traveler-returning-from-guyana
#20
Ryan G Fabrizius, Kathryn Anderson, Brett Hendel-Paterson, Robyn M Kaiser, Salahudin Maalim, Patricia F Walker
Zika virus (ZIKV) is a mosquito-borne flavivirus with a significant public health impact highlighted by the ongoing epidemic in the Americas. We describe a 44-year-old male presenting to our tropical medicine center with complaints of fever, headache, joint pain, and rash after recent travel to Guyana. The patient subsequently developed gait imbalance and lower extremity weakness with clinical examination, cerebrospinal fluid studies, and magnetic resonance imaging of the spine consistent with a diagnosis of Guillain-Barré syndrome (GBS)...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
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