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Pedro Costa Del Amo, Julio Lahoz Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith
Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are responsible for maintaining memory. However, it is not clear if the dynamics of TSCM cells in vivo are compatible with this hypothesis. To address this issue, we investigated the dynamics of TSCM cells under physiological conditions in humans in vivo using a multidisciplinary approach that combines mathematical modelling, stable isotope labelling, telomere length analysis, and cross-sectional data from vaccine recipients...
June 22, 2018: PLoS Biology
Latifah Amin, Hasrizul Hashim, Zurina Mahadi, Anisah Che Ngah, Khaidzir Ismail
BACKGROUND: Advances in xenotransplantation have the potential to resolve the issue of organ shortages. Despite this, the procedure is expected to meet with a degree of resistance from the public. The purpose of this study was to identify the relevant factors influencing stakeholders' attitudes towards xenotransplantation. METHODS: A multidimensional survey instrument measuring attitudes to xenotransplantation, including the factors that predict such attitudes, was developed based on earlier studies and validated...
June 22, 2018: Xenotransplantation
Assaf A Barg, Sarah Malkiel, Maya Bartuv, Gahl Greenberg, Amos Toren, Nathan Keller
BACKGROUND: Invasive mold infections (IMIs) are a leading cause of mortality among immunocompromised patients. Isavuconazole is a new drug that shows promise in the adult population for the treatment of IMIs. No data regarding the use of isavuconazole in pediatric patients have been published. METHODS: Patients with a diagnosis of IMI from our pediatric hemato-oncology division, treated with isavuconazole between 2010 and 2016, were identified using the hospital's computerized database...
June 22, 2018: Pediatric Blood & Cancer
Pablo E García-Granja, David Dobarro, Cristina Tapia, Gonzalo Fernández-Palacios, Álvaro Aparisi, Ernesto Del Amo, Marina Revilla, María Azpeitia, Itziar Gómez, María J Rollán, J Alberto San Román
No abstract text is available yet for this article.
January 1, 2018: European Journal of Preventive Cardiology
Javier Conesa-Egea, Carlos D Redondo, J Ignacio Martínez, Carlos J Gómez-García, Óscar Castillo, Félix Zamora, Pilar Amo-Ochoa
Two coordination polymers (CPs), based on Cu(I)-I double zig-zag chains bearing isonicotinic acid or 3-chloroisonicotinic acid as terminal ligands with molecular recognition capabilities, have been synthesized and fully characterized. Both compounds present extended networks with supramolecular interactions directed by the formation of H-bonds between the complementary carboxylic groups, giving supramolecular sheets. The chloro substituent allows establishing additional Cl···Cl supramolecular interactions that reinforce the stability of the supramolecular sheets...
June 21, 2018: Inorganic Chemistry
Jinyoung Byun, Ann G Schwartz, Christine Lusk, Angela S Wenzlaff, Mariza de Andrade, Diptasri Mandal, Colette Gaba, Ping Yang, Ming You, Elena Y Kupert, Marshall W Anderson, Younghun Han, Yafang Li, David Qian, Adrienne Stilp, Cathy Laurie, Sarah Nelson, Wenying Zheng, Rayjean J Hung, Valerie Gaborieau, James Mckay, Paul Brennan, Neil E Caporaso, Maria Teresa Landi, Xifeng Wu, John R McLaughlin, Yonathan Brhane, Yohan Bossé, Susan M Pinney, Joan E Bailey-Wilson, Christopher I Amos
To identify genetic variation associated with lung cancer risk, we performed a genome-wide association analysis of 685 lung cancer cases that had a family history of two or more first or second degree relatives compared with 744 controls without lung cancer that were genotyped on an Illumina Human OmniExpressExome-8v1 array. To ensure robust results, we further evaluated these findings using data from six additional studies that were assembled through the Transdisciplinary Research on Cancer of the Lung Consortium comprising 1,993 familial cases and 33,690 controls...
June 19, 2018: Carcinogenesis
Pankaj Sharma, Amos Samkumar, Mahesh Rao, Vijay V Singh, Lakshman Prasad, Dwijesh C Mishra, Ramcharan Bhattacharya, Navin C Gupta
White mold or stem rot disease are ubiquitously distributed throughout the world and the causal organism of this disease Sclerotinia sclerotiorum (Lib.) de Bary, is known to infect over 400 plant species. Sclerotinia stem rot is one of the most devastating fungal diseases and poses a serious threat to the worldwide cultivation of oilseed Brassica including India. S. sclerotiorum pathogen usually infects the stem but in severe cases leaves and pods also affected at different developmental stages that deteriorate not only the oil quality but also causing the seed and oil yield losses up to 90% depending on the severity of the disease infestation...
2018: Frontiers in Microbiology
Wenjie Zhang, Tony B Amos, Stephen W Gutkin, Nicole Lodowski, Emma Giegerich, Kruti Joshi
Purpose: The aim of this study was to conduct a systematic literature review on the burden of schizophrenia in privately insured US patients. Materials and methods: A systematic literature review of English language peer-reviewed journal articles of observational studies published from 2006 to 2016 was conducted using EMBASE/MEDLINE databases. Abstracts covering substantial numbers of patients with schizophrenia or schizoaffective disorder (i.e., N ≥ 100) were included for full-text review...
2018: ClinicoEconomics and Outcomes Research: CEOR
Andrew Self, Samuel Chipokosa, Amos Misomali, Tricia Aung, Steven A Harvey, Mercy Chimchere, James Chilembwe, Lois Park, Chrissie Chalimba, Edson Monjeza, Fannie Kachale, Jameson Ndawala, Melissa A Marx
BACKGROUND: Malawi has made progress in increasing its overall modern contraceptive prevalence rate since 2000, resulting in a dramatic reduction in its total fertility rate. However, youth, 15-24 years, have not had the same successes. Teenage pregnancies are on the rise and little progress has been made in reducing unmet need for family planning among youth. With two-thirds of the population under the age of 25 and with Malawi's rapid population growth, reducing unmet need for family planning among youth remains a priority for the government's reproductive health agenda...
June 19, 2018: Reproductive Health
Stephanie L Schmit, Christopher K Edlund, Fredrick R Schumacher, Jian Gong, Tabitha A Harrison, Jeroen R Huyghe, Chenxu Qu, Marilena Melas, David J Van Den Berg, Hansong Wang, Stephanie Tring, Sarah J Plummer, Demetrius Albanes, M Henar Alonso, Christopher I Amos, Kristen Anton, Aaron K Aragaki, Volker Arndt, Elizabeth L Barry, Sonja I Berndt, Stéphane Bezieau, Stephanie Bien, Amanda Bloomer, Juergen Boehm, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Jose E Castelao, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Iona Cheng, Ya-Wen Cheng, Lee Soo Chin, James M Church, Timothy Church, Gerhard A Coetzee, Michelle Cotterchio, Marcia Cruz Correa, Keith R Curtis, David Duggan, Douglas F Easton, Dallas English, Edith J M Feskens, Rocky Fischer, Liesel M FitzGerald, Barbara K Fortini, Lars G Fritsche, Charles S Fuchs, Manuela Gago-Dominguez, Manish Gala, Steven J Gallinger, W James Gauderman, Graham G Giles, Edward L Giovannucci, Stephanie M Gogarten, Clicerio Gonzalez-Villalpando, Elena M Gonzalez-Villalpando, William M Grady, Joel K Greenson, Andrea Gsur, Marc Gunter, Christopher A Haiman, Jochen Hampe, Sophia Harlid, John F Harju, Richard B Hayes, Philipp Hofer, Michael Hoffmeister, John L Hopper, Shu-Chen Huang, Jose Maria Huerta, Thomas J Hudson, David J Hunter, Gregory E Idos, Motoki Iwasaki, Rebecca D Jackson, Eric J Jacobs, Sun Ha Jee, Mark A Jenkins, Wei-Hua Jia, Shuo Jiao, Amit D Joshi, Laurence N Kolonel, Suminori Kono, Charles Kooperberg, Vittorio Krogh, Tilman Kuehn, Sébastien Küry, Andrea LaCroix, Cecelia A Laurie, Flavio Lejbkowicz, Mathieu Lemire, Heinz-Josef Lenz, David Levine, Christopher I Li, Li Li, Wolfgang Lieb, Yi Lin, Noralane M Lindor, Yun-Ru Liu, Fotios Loupakis, Yingchang Lu, Frank Luh, Jing Ma, Christoph Mancao, Frank J Manion, Sanford D Markowitz, Vicente Martin, Koichi Matsuda, Keitaro Matsuo, Kevin J McDonnell, Caroline E McNeil, Roger Milne, Antonio J Molina, Bhramar Mukherjee, Neil Murphy, Polly A Newcomb, Kenneth Offit, Hanane Omichessan, Domenico Palli, Jesus P Paredes Cotoré, Julyann Pérez-Mayoral, Paul D Pharoah, John D Potter, Conghui Qu, Leon Raskin, Gad Rennert, Hedy S Rennert, Bridget M Riggs, Clemens Schafmayer, Robert E Schoen, Thomas A Sellers, Daniela Seminara, Gianluca Severi, Wei Shi, David Shibata, Xiao-Ou Shu, Erin M Siegel, Martha L Slattery, Melissa Southey, Zsofia K Stadler, Mariana C Stern, Sebastian Stintzing, Darin Taverna, Stephen N Thibodeau, Duncan C Thomas, Antonia Trichopoulou, Shoichiro Tsugane, Cornelia M Ulrich, Franzel J B van Duijnhoven, Bethany van Guelpan, Joseph Vijai, Jarmo Virtamo, Stephanie J Weinstein, Emily White, Aung Ko Win, Alicja Wolk, Michael Woods, Anna H Wu, Kana Wu, Yong-Bing Xiang, Yun Yen, Brent W Zanke, Yi-Xin Zeng, Ben Zhang, Niha Zubair, Sun-Seog Kweon, Jane C Figueiredo, Wei Zheng, Loic Le Marchand, Annika Lindblom, Victor Moreno, Ulrike Peters, Graham Casey, Li Hsu, David V Conti, Stephen B Gruber
Background: Previous genome-wide association studies (GWAS) have identified 42 loci (P < 5 × 10-8) associated with risk of colorectal cancer (CRC). Expanded consortium efforts facilitating the discovery of additional susceptibility loci may capture unexplained familial risk. Methods: We conducted a GWAS in European descent CRC cases and control subjects using a discovery-replication design, followed by examination of novel findings in a multiethnic sample (cumulative n = 163 315)...
June 16, 2018: Journal of the National Cancer Institute
Amir Giladi, Franziska Paul, Yoni Herzog, Yaniv Lubling, Assaf Weiner, Ido Yofe, Diego Jaitin, Nina Cabezas-Wallscheid, Regine Dress, Florent Ginhoux, Andreas Trumpp, Amos Tanay, Ido Amit
The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent stem cells in the bone marrow remain controversial. Here we dissect haematopoietic progenitor populations at single cell resolution, deriving an unbiased reference model of transcriptional states in normal and perturbed murine bone marrow. We define the signature of the naive haematopoietic stem cell and find a continuum of core progenitor states. Core cell populations mix transcription of pre-myeloid and pre-lymphoid programs, but do not mix erythroid or megakaryocyte programs with other fates...
June 18, 2018: Nature Cell Biology
Navid Madani, Amy M Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A Zhao, Brandon P Conn, Todd Bradley, M Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F Haynes, Amos B Smith Iii, Sampa Santra, Joseph Sodroski
The envelope glycoprotein (Env) trimer ((gp120/gp41)3 ) mediates human immunodeficiency virus (HIV-1) entry into cells. The "closed," antibody-resistant Env trimer is driven to more open conformations by binding the host receptor, CD4. Broadly neutralizing antibodies that recognize conserved elements of the closed Env are potentially protective, but are elicited inefficiently. HIV-1 has evolved multiple mechanisms to evade readily elicited antibodies against more open Env conformations. Small-molecule CD4-mimetic compounds (CD4mc) bind the HIV-1 gp120 Env and promote conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies...
June 18, 2018: Nature Communications
Courtland S Hyatt, Brandon M Weiss, Nathan T Carter, Amos Zeichner, Joshua D Miller
Narcissism has been robustly linked to self-report and lab-based measures of aggression. However, less is known about the role that a competitive context may play in the relations found between narcissism and aggression as measured in behavioral paradigms. In circumstances of competition, narcissistic individuals may be particularly attuned to external indicators of status and use aggression as a way of asserting power and a motivation to "win," rather than to do harm. The goal of the present study was to test the role of competition in understanding the relation between narcissism and related traits (i...
June 18, 2018: Personality Disorders
Luis Miguel García, Carlos Iniesta, Jorge Garrido, María José Fuster, Ferran Pujol, Michael Meulbroek, Toni Poveda, Melchor Riera, Antonio Antela, Santiago Moreno, David Dalmau, Antonio Rivero, Diego García, Ramón Espacio, Julia Del Amo
This study focuses on actions at the political and administrative level in Spain in relation to the implementation of pre-exposure prophylaxis (PrEP). We analysed a whole range of different formal initiatives taken by the political and administrative actors involved. The information was obtained from official public data sources. As of February 2018, PrEP had not been implemented. The decision is dependent on both state and regional governments. The Ministry of Health and some Autonomous Regions are working on different interventions, but without providing an implementation timetable...
June 14, 2018: Enfermedades Infecciosas y Microbiología Clínica
Jaime Madrigal-González, Enrique Andivia, Miguel A Zavala, Markus Stoffel, Joaquín Calatayud, Raúl Sánchez-Salguero, Juan Ballesteros-Cánovas
Climate change can impair ecosystem functions and services in extensive dry forests worldwide. However, attribution of climate change impacts on tree growth and forest productivity is challenging due to multiple inter-annual patterns of climatic variability associated with atmospheric and oceanic circulations. Moreover, growth responses to rising atmospheric CO2 , namely carbon fertilization, as well as size ontogenetic changes can obscure the climate change signature as well. Here we apply Structural Equation Models (SEM) to investigate the relative role of climate change on tree growth in an extreme Mediterranean environment (i...
June 14, 2018: Science of the Total Environment
Malak Aoun, Norlena Hasnan, Hassan Al-Aaraj
Background: Lean practices are critical to eliminate waste and enhance the quality of healthcare services through different improvement approaches of total quality management (TQM). In particular, the soft side of TQM is used to develop the innovation skills of employees that are essential for the continuous improvement strategies of hospitals. Aim: The main objective was to study the relationship between lean practices, soft TQM and innovation skills in Lebanese hospitals...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
Stefanie Frey-Jakobs, Julia M Hartberger, Manfred Fliegauf, Claudia Bossen, Magdalena L Wehmeyer, Johanna C Neubauer, Alla Bulashevska, Michele Proietti, Philipp Fröbel, Christina Nöltner, Linlin Yang, Jessica Rojas-Restrepo, Niko Langer, Sandra Winzer, Karin R Engelhardt, Cristina Glocker, Dietmar Pfeifer, Adi Klein, Alejandro A Schäffer, Irina Lagovsky, Idit Lachover-Roth, Vivien Béziat, Anne Puel, Jean-Laurent Casanova, Bernhard Fleckenstein, Stephan Weidinger, Sara S Kilic, Ben-Zion Garty, Amos Etzioni, Bodo Grimbacher
Signal transducer and activator of transcription 3 (STAT3) is a central regulator of immune homeostasis. STAT3 levels are strictly controlled, and STAT3 impairment contributes to several diseases including the monogenic autosomal-dominant hyper-immunoglobulin E (IgE) syndrome (AD-HIES). We investigated patients of four consanguineous families with an autosomal-recessive disorder resembling the phenotype of AD-HIES, with symptoms of immunodeficiency, recurrent infections, skeletal abnormalities, and elevated IgE...
June 15, 2018: Science Immunology
Baruch Levi, Amos Zehavi, David Chinitz
Systematic measurement of healthcare services enables evaluation of health professionals' quality of work. Whereas policy makers find measurement a useful mechanism for quality improvement, a public choice perspective implies that physicians would resent such an initiative, which undermines their professional autonomy. In this article, we compare two healthcare systems of economically developed countries - Israel and the UK. Both systems share common features such as universal coverage, strong state intervention, and enthusiasm for New Public Management...
June 8, 2018: Health Policy
Loren Koçillari, Piero Fariselli, Antonio Trovato, Flavio Seno, Amos Maritan
Proteins have coevolved with cellular environments to improve or preserve their functions, maintaining at the same time the degree of hydrophobicity necessary to fold correctly and enough solubility to perform their biological roles. Here, we study the Escherichia coli proteome using a Pareto front analysis in the solubility-hydrophobicity space. The results indicate the existence of a Pareto optimal front, a triangle whose vertices correspond to archetypal proteins specialized in distinct tasks, such as regulatory processes, membrane transport, outer-membrane pore formation, catalysis, and binding...
June 14, 2018: Scientific Reports
Michal Polonsky, Jacob Rimer, Amos Kern-Perets, Irina Zaretsky, Stav Miller, Chamutal Bornstein, Eyal David, Naama Meira Kopelman, Gil Stelzer, Ziv Porat, Benjamin Chain, Nir Friedman
Cell differentiation is directed by signals driving progenitors into specialized cell types. This process can involve collective decision-making, when differentiating cells determine their lineage choice by interacting with each other. We used live-cell imaging in microwell arrays to study collective processes affecting differentiation of naïve CD4+ T cells into memory precursors. We found that differentiation of precursor memory T cells sharply increases above a threshold number of locally interacting cells...
June 15, 2018: Science
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