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https://www.readbyqxmd.com/read/28319128/serious-adverse-neonatal-outcomes-such-as-5-minute-apgar-score-of-zero-and-seizures-or-severe-neurologic-dysfunction-are-increased-in-planned-home-births-after-cesarean-delivery
#1
Amos Grünebaum, Laurence B McCullough, Birgit Arabin, Frank A Chervenak
The United States is with 37,451 home births in 2014 the country with the largest absolute number of home births among all developed countries. The purpose of this study was to examine the occurrence and risks of a 5-minute Apgar score of zero and neonatal seizures or serious neurologic dysfunction in women with a history of prior cesarean delivery for planned home vaginal birth after cesarean (VBAC), compared to hospital VBAC and hospital birth cesarean deliveries for term normal weight infants in the United States from 2007-2014...
2017: PloS One
https://www.readbyqxmd.com/read/28306747/hypothermic-stunning-of-green-sea-turtles-in-a-western-gulf-of-mexico-foraging-habitat
#2
Donna J Shaver, Philippe E Tissot, Mary M Streich, Jennifer Shelby Walker, Cynthia Rubio, Anthony F Amos, Jeffrey A George, Michelle R Pasawicz
Texas waters provide one of the most important developmental and foraging habitats for juvenile green turtles (Chelonia mydas) in the western Gulf of Mexico, but hypothermic stunning is a significant threat and was the largest cause of green turtle strandings in Texas from 1980 through 2015; of the 8,107 green turtles found stranded, 4,529 (55.9%) were victims of hypothermic stunning. Additionally, during this time, 203 hypothermic stunned green turtles were found incidentally captured due to power plant water intake entrapment...
2017: PloS One
https://www.readbyqxmd.com/read/28304396/associations-between-genetic-variants-in-mrna-splicing-related-genes-and-risk-of-lung-cancer-a-pathway-based-analysis-from-published-gwass
#3
Yongchu Pan, Hongliang Liu, Yanru Wang, Xiaozheng Kang, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, Yongyue Wei, Rayjean J Hung, Yonathan Brhane, John McLaughlin, Paul Brennan, Heike Bickeböller, Albert Rosenberger, Richard S Houlston, Neil Caporaso, Maria Teresa Landi, Joachim Heinrich, Angela Risch, Xifeng Wu, Yuanqing Ye, David C Christiani, Christopher I Amos, Qingyi Wei
mRNA splicing is an important mechanism to regulate mRNA expression. Abnormal regulation of this process may lead to lung cancer. Here, we investigated the associations of 11,966 single-nucleotide polymorphisms (SNPs) in 206 mRNA splicing-related genes with lung cancer risk by using the summary data from six published genome-wide association studies (GWASs) of Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16,838 controls) and another two lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1,319 cases and 26,380 controls)...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303588/dietary-consumption-of-monosodium-l-glutamate-induces-adaptive-response-and-reduction-in-the-life-span-of-drosophila-melanogaster
#4
Amos O Abolaji, Charles O Olaiya, Oluwagbenga J Oluwadahunsi, Ebenezer O Farombi
Adaptive response is the ability of an organism to better counterattack stress-induced damage in response to a number of different cytotoxic agents. Monosodium L-glutamate (MSG), the sodium salt of amino acid glutamate, is commonly used as a food additive. We investigated the effects of MSG on the life span and antioxidant response in Drosophila melanogaster (D. melanogaster). Both genders (1 to 3 days old) of flies were fed with diet containing MSG (0.1, 0.5, and 2.5-g/kg diet) for 5 days to assess selected antioxidant and oxidative stress markers, while flies for longevity were fed for lifetime...
March 16, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28302473/quantitative-relationship-between-chemical-properties-and-bioactivities-of-anti-microrna-oligonucleotides-targeted-to-tumor-associated-microrna-21
#5
Koji Nagahama, Kenta Iseda, Daichi Kawano, Junji Kawakami
Synthetic anti-microRNA oligonucleotides (AMOs) are promising drug candidates to inactivate disease-related microRNAs because of their sequence-specific binding to their targets and the variety of chemical modifications available. Over the last decade, the qualitative relationships between the chemical properties of AMOs and bioactivity (inactivation of their target miRNAs) have been studied to enhance their bioactivity. On the other hand, in real-world drug development, drugs must be designed case-by-case, taking many factors into account...
March 13, 2017: Biochimie
https://www.readbyqxmd.com/read/28300416/correction-to-prediction-of-ocular-drug-distribution-from-systemic-blood-circulation
#6
Kati-Sisko Vellonen, Esa-Matti Soini, Eva M Del Amo, Arto Urtti
No abstract text is available yet for this article.
March 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28300261/quantifying-3d-chemotaxis-in-microfluidic-based-chips-with-step-gradients-of-collagen-hydrogel-concentrations
#7
C Del Amo, C Borau, N Movilla, Jesús Asín, J M García-Aznar
Cell migration is an essential process involved in crucial stages of tissue formation, regeneration or immune function as well as in pathological processes including tumor development or metastasis. During the last few years, the effect of gradients of soluble molecules on cell migration has been widely studied, and complex systems have been used to analyze cell behavior under simultaneous mechano-chemical stimuli. Most of these chemotactic assays have, however, focused on specific substrates in 2D. The aim of the present work is to develop a novel microfluidic-based chip that allows the long-term chemoattractant effect of growth factors (GFs) on 3D cell migration to be studied, while also providing the possibility to analyze the influence of the interface generated between different adjacent hydrogels...
March 16, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28298291/plasmablast-response-to-primary-rhesus-cytomegalovirus-infection-in-a-monkey-model-of-congenital-cmv-transmission
#8
Qihua Fan, Cody S Nelson, Kristy M Bialas, Flavia Chiuppesi, Joshua Amos, Thaddeus C Gurley, Dawn Jones Marshall, Joshua Eudailey, Holly Heimsath, Jonathon Himes, Ashlesha Deshpande, Mark R Walter, Felix Wussow, Don J Diamond, Peter A Barry, M Anthony Moody, Amitinder Kaur, Sallie R Permar
Human cytomegalovirus (HCMV) is the most common congenital infection worldwide, and the leading infectious cause of neurologic deficits and hearing loss in newborns. Development of a maternal HCMV vaccine to prevent vertical virus transmission is a high priority, yet protective maternal immune responses following acute infection are poorly understood. To characterize the maternal humoral immune response to primary CMV infection, we investigated the plasmablast and early antibody repertoire using a nonhuman primate model with two acutely rhesus CMV (RhCMV) infected animals - a CD4+ T cell-depleted dam that experienced fetal loss shortly after vertical RhCMV transmission and an immunocompetent dam that did not transmit RhCMV to her infant...
March 15, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28292532/-intravenous-iron-functional-recovery-and-delirium-in-patients-with-hip-fracture-federef-study-single-centre-randomised-placebo-controlled-and-double-blind-clinical-trial-2014-001923-53-eudract-number
#9
Rafael Bielza Galindo, Jesús Llorente Gutiérrez, José Luis Pérez González, Asunción Mora Casado, David Blanco Díaz, Javier Escalera Alonso, Adoración Morales Fernández, Cristina Molano Ortiz, Beredys Esmirla García López, Nazaret Del Amo Del Arco, Juan Pablo Barro Ordovas, Estefanía Arias Muñana, Marta Neira Álvarez, David Sanz Rosa, Jorge Fco Gómez Cerezo
INTRODUCTION: There are no previous studies evaluating the effect of intravenous iron therapy on functional and cognitive status of patients with hip fracture (HF). MATERIAL AND METHODS: A single-centre randomised, placebo-controlled, double-blind and parallel treatment, clinical trial has been designed to assess the efficacy of intravenous iron therapy during the peri-operative period in elderly patients suffering from a HF. Blinding will be ensured by the packaging of the drug infusion system...
March 11, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28291684/identification-of-compounds-with-cytotoxic-activity-from-the-leaf-of-the-nigerian-medicinal-plant-anacardium-occidentale-l-anacardiaceae
#10
Bamigboye J Taiwo, Amos A Fatokun, Olujide O Olubiyi, Olukemi T Bamigboye-Taiwo, Fanie R van Heerden, Colin W Wright
Cancer is now the second-leading cause of mortality and morbidity, behind only heart disease, necessitating urgent development of (chemo)therapeutic interventions to stem the growing burden of cancer cases and cancer death. Plants represent a credible source of promising drug leads in this regard, with a long history of proven use in the indigenous treatment of cancer. This study therefore investigated Anacardium occidentale, one of the plants in a Nigerian Traditional Medicine formulation commonly used to manage cancerous diseases, for cytotoxic activity...
February 22, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28291517/towards-a-chromatographic-similarity-index-to-establish-localised-quantitative-structure-retention-relationships-for-retention-prediction-ii-use-of-tanimoto-similarity-index-in-ion-chromatography
#11
Soo Hyun Park, Mohammad Talebi, Ruth I J Amos, Eva Tyteca, Paul R Haddad, Roman Szucs, Christopher A Pohl, John W Dolan
Quantitative Structure-Retention Relationships (QSRR) are used to predict retention times of compounds based only on their chemical structures encoded by molecular descriptors. The main concern in QSRR modelling is to build models with high predictive power, allowing reliable retention prediction for the unknown compounds across the chromatographic space. With the aim of enhancing the prediction power of the models, in this work, our previously proposed QSRR modelling approach called "federation of local models" is extended in ion chromatography to predict retention times of unknown ions, where a local model for each target ion (unknown) is created using only structurally similar ions from the dataset...
February 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28290713/the-influence-of-growth-and-e-coli-endotoxaemia-on-amoxicillin-pharmacokinetics-in-turkeys
#12
B Poźniak, U Pasławska, K Motykiewicz-Pers, M Świtała
1. This experiment was designed to determine if the pharmacokinetics of amoxicillin (AMO) was affected by rapid growth or the acute phase reaction induced by intravenous (i.v.) injection of E. coli lipopolysaccharide (LPS). 2. Turkeys of 2.0, 5.5 and 12.0 kg were administered i.v. or orally with AMO sodium at the dose of 15 mg/kg. One group of turkeys (5.7 kg) was treated with LPS 1 h prior to i.v. AMO administration. Plasma drug concentrations were determined using high-performance liquid chromatography and pharmacokinetic parameters were calculated using a non-compartmental model...
March 14, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28288843/non-invasive-diagnosis-of-cutaneous-leishmaniasis-by-the-direct-boil-loop-mediated-isothermal-amplification-method-and-minion%C3%A2-nanopore-sequencing
#13
Kazuo Imai, Norihito Tarumoto, Kiyoko Amo, Makoto Takahashi, Naoya Sakamoto, Atsushi Kosaka, Yasuyuki Kato, Kei Mikita, Jun Sakai, Takashi Murakami, Yutaka Suzuki, Shigefumi Maesaki, Takuya Maeda
Cutaneous leishmaniasis (CL) is gaining attention as a public health problem. We present two cases of CL imported from Syria and Venezuela in Japan. We diagnosed them as CL non-invasively by the direct boil loop-mediated isothermal amplification method and an innovative sequencing method using the MinION™ sequencer. This report demonstrates that our procedure could be useful for the diagnosis of CL in both clinical and epidemiological settings.
March 11, 2017: Parasitology International
https://www.readbyqxmd.com/read/28287691/effects-of-housing-on-methamphetamine-induced-neurotoxicity-and-spatial-learning-and-memory
#14
Arnold Gutierrez, Sarah A Jablonski, Robyn M Amos-Kroohs, Anna C Barnes, Michael T Williams, Charles V Vorhees
Severe stress potentiates methamphetamine (MA) neurotoxicity. However, whether moderate stress increases or decreases the neurotoxic effects of MA is unknown. We assessed the effects of MA (4 x 10 mg/kg at 2 h intervals) in combination with prior barren-cage housing in adult male Sprague-Dawley rats on monoamines and glial fibrillary acid protein (GFAP) in one cohort and spatial learning and memory in the Morris water maze in another cohort. MA reduced dopamine (DA) and serotonin (5-HT) in the neostriatum and nucleus accumbens, 5-HT in the hippocampus, and increased GFAP in neostriatum and nucleus accumbens compared with saline controls...
March 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28283802/nitrogen-metabolism-genes-from-temperate-marine-sediments
#15
Carolina Reyes, Dominik Schneider, Marko Lipka, Andrea Thürmer, Michael E Böttcher, Michael W Friedrich
In this study, we analysed metagenomes along with biogeochemical profiles from Skagerrak (SK) and Bothnian Bay (BB) sediments, to trace the prevailing nitrogen pathways. NO3(-) was present in the top 5 cm below the sediment-water interface at both sites. NH4(+) increased with depth below 5 cm where it overlapped with the NO3(-) zone. Steady-state modelling of NO3(-) and NH4(+) porewater profiles indicates zones of net nitrogen species transformations. Bacterial protease and hydratase genes appeared to make up the bulk of total ammonification genes...
March 10, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/28280789/reduction-in-operator-radiation-exposure-during-transradial-coronary-procedures-using-a-simple-lead-rectangle
#16
Azriel B Osherov, Sharon Bruoha, Avishag Laish Farkash, Gideon Paul, Ian Orlov, Amos Katz, Jamal Jafari
OBJECTIVES: Transradial access for percutaneous coronary intervention (PCI) reduces procedural complications however, there are concerns regarding the potential for increased exposure to ionizing radiation to the primary operator. We evaluated the efficacy of a lead-attenuator in reducing radiation exposure during transradial PCI. METHODS AND RESULTS: This was a non-randomized, prospective, observational study in which 52 consecutive patients were assigned to either standard operator protection (n = 26) or the addition of the lead attenuator across their abdomen/pelvis (n = 26)...
February 2017: Heliyon
https://www.readbyqxmd.com/read/28280580/organization-of-biogeochemical-nitrogen-pathways-with-switch-like-adjustment-in-fluctuating-soil-redox-conditions
#17
Sanjay Lamba, Soumen Bera, Mubasher Rashid, Alexander B Medvinsky, Gui-Quan Sun, Claudia Acquisti, Amit Chakraborty, Bai-Lian Li
Nitrogen is cycled throughout ecosystems by a suite of biogeochemical processes. The high complexity of the nitrogen cycle resides in an intricate interplay between reversible biochemical pathways alternatively and specifically activated in response to diverse environmental cues. Despite aggressive research, how the fundamental nitrogen biochemical processes are assembled and maintained in fluctuating soil redox conditions remains elusive. Here, we address this question using a kinetic modelling approach coupled with dynamical systems theory and microbial genomics...
January 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28277891/comparing-the-weefim-and-pedi-in-neurorehabilitation-for-children-with-acquired-brain-injury-a-systematic-review
#18
Katie S Williams, David K Young, G A Amos Burke, Daniel M Fountain
INTRODUCTION: We sought to compare the suitability of the Functional Independence Measure for Children (WeeFIM) and the Pediatric Evaluation of Disability Inventory (PEDI) as outcome measures in rehabilitation of children with acquired brain injury (ABI). METHODS: We performed a systematic review of the evidence base using five databases. PRISMA guidelines were adhered to and the review was registered with the PROSPERO international prospective register of systematic reviews (registration number CRD42015025370)...
March 9, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28275629/evaluating-tavi-outcomes-not-just-a-matter-of-life-and-death
#19
COMMENT
Amos Levi, Ran Kornowski
No abstract text is available yet for this article.
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28274905/a-learning-health-care-system-using-computer-aided-diagnosis
#20
Amos Cahan, James J Cimino
Physicians intuitively apply pattern recognition when evaluating a patient. Rational diagnosis making requires that clinical patterns be put in the context of disease prior probability, yet physicians often exhibit flawed probabilistic reasoning. Difficulties in making a diagnosis are reflected in the high rates of deadly and costly diagnostic errors. Introduced 6 decades ago, computerized diagnosis support systems are still not widely used by internists. These systems cannot efficiently recognize patterns and are unable to consider the base rate of potential diagnoses...
March 8, 2017: Journal of Medical Internet Research
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