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https://www.readbyqxmd.com/read/28091657/zinc-transport-and-the-inhibition-of-the-l-type-calcium-channel-are-two-separable-functions-of-znt-1
#1
Eden Shusterman, Ofer Beharier, Shiri Levy, Raz Zarivach, Yoram Etzion, Craig R Campbell, Il-Ha Lee, Anuwat Dinudom, David I Cook, Asher Peretz, Amos Katz, Daniel Gitler, Arie Moran
Traditionally, proteins are considered to perform a single role, be it as an enzyme, a channel, a transporter or as a structural scaffold. However, recent studies have described moonlighting proteins that perform distinct and independent functions; for example, TRPM7 is both an ion channel and a kinase. ZnT-1 is a member of the Carrier Diffusion Facilitator family that is expressed throughout the phylogenetic tree from bacteria to humans. Since its cloning in 1995, ZnT-1 is considered a major extruder of Zn(2+) based on its capability to protect cells against zinc toxicity...
January 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28087884/the-role-of-immunoglobulin-prophylaxis-for-prevention-of-cytomegalovirus-infection-in-pediatric-hematopoietic-stem-cell-transplantation-recipients
#2
Gal Goldstein, Tal Frenkel Rutenberg, Sarina Levy Mendelovich, Daphna Hutt, Michal Teperberg Oikawa, Amos Toren, Bella Bielorai
BACKGROUND: Following cessation of intravenous immunoglobulin (IVIg) administration for allogeneic hematopoietic stem cell transplantation (HSCT) recipients at our unit, we observed a sharp decline in the incidence of cytomegalovirus (CMV) infection. PROCEDURE: We conducted a retrospective study of the role of IVIg in the prevention of CMV infection in children and young adults who underwent HSCT from matched related donor. RESULTS: We included 109 patients (IVIg+/IVIg- ratio 82/27)...
January 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28087586/using-e-cigarettes-in-the-home-to-reduce-smoking-and-secondhand-smoke-disadvantaged-parents-accounts
#3
Neneh Rowa-Dewar, Catriona Rooke, Amanda Amos
Electronic cigarettes (e-cigarettes) are subject to considerable public health debate. Most public health experts agree that for smokers who find it particularly challenging to quit, e-cigarettes may reduce harm. E-cigarette use in the home may also reduce children's secondhand smoke (SHS) exposure, although e-cigarette vapour may pose risks. This is the first qualitative study to explore disadvantaged parents' views and experiences of e-cigarettes in relation to reducing SHS exposure in the home. Interviews with 25 disadvantaged parents from Edinburgh who smoked and had children aged 1-3 were conducted in 2013, with 17 re-interviewed in 2014...
January 13, 2017: Health Education Research
https://www.readbyqxmd.com/read/28086864/direct-detection-of-falciparum-and-non-falciparum-malaria-dna-from-a-drop-of-blood-with-high-sensitivity-by-the-dried-lamp-system
#4
Kyoko Hayashida, Kiichi Kajino, Humphrey Simukoko, Martin Simuunza, Joseph Ndebe, Amos Chota, Boniface Namangala, Chihiro Sugimoto
BACKGROUND: Because of the low sensitivity of conventional rapid diagnostic tests (RDTs) for malaria infections, the actual prevalence of the diseases, especially those caused by non-Plasmodium falciparum (non-Pf) species, in asymptomatic populations remain less defined in countries lacking in well-equipped facilities for accurate diagnoses. Our direct blood dry LAMP system (CZC-LAMP) was applied to the diagnosis of malaria as simple, rapid and highly sensitive method as an alternative for conventional RDTs in malaria endemic areas where laboratory resources are limited...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28077830/-path-analysis-of-the-influence-of-hospital-ethical-climate-perceived-by-nurses-on-supervisor-trust-and-organizational-effectiveness
#5
Yoon Goo Noh, Myun Sook Jung
PURPOSE: The purpose of this study was to analyze the paths of influence that a hospital's ethical climate exerts on nurses' organizational commitment and organizational citizenship behavior, with supervisor trust as the mediating factor, and verify compatibility of the models in hospital nurses. METHODS: The sample consisted of 374 nurses recruited from four hospitals in 3 cities in Korea. The measurements included the Ethical Climate Questionnaire, Supervisor Trust Questionnaire, Organizational Commitment Questionnaire and Organizational Citizenship Behavior Questionnaire...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28070732/the-clinical-and-laboratory-spectrum-of-dedicator-of-cytokinesis-8-immunodeficiency-syndrome-in-patients-with-a-unique-mutation
#6
Arnon Broides, Amarilla B Mandola, Jacov Levy, Baruch Yerushalmi, Vered Pinsk, Michal Eldan, George Shubinsky, Nurit Hadad, Rachel Levy, Amit Nahum, Miriam Ben-Harosh, Atar Lev, Amos Simon, Raz Somech
Mutations in the dedicator of cytokinesis 8 (DOCK8) gene cause a combined immunodeficiency usually diagnosed as autosomal recessive hyper IgE syndrome. We sought to reveal the varying manifestations in patients with a unique mutation in DOCK8 gene by a retrospective medical record review. Ten patients from five consanguineous families and three tribes were included. Seven patients were homozygous for the c.C5134A, p.S1711X mutation, and the remaining three patients were their siblings manifesting hyper IgE syndrome features without a genetic diagnosis...
January 10, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28068375/validation-of-the-spanish-version-of-the-icecap-o-for-nursing-home-residents-with-dementia
#7
Carmen M Sarabia-Cobo, Paula Parás-Bravo, Francisco José Amo-Setién, Ana Rosa Alconero-Camarero, María Sáenz-Jalón, Blanca Torres-Manrique, Raquel Sarabia-Lavín, Angela Fernández-Rodríguez, Tamara Silio-García, Rosario Fernández-Peña, María Paz-Zulueta, Miguel Santibáñez-Margüello
BACKGROUND: Measurement of health-related quality of life (HRQoL) is important for a chronic disease, such as dementia, which impairs the quality of life of affected patients in addition to their length of life. This is important in the context of economic evaluations when interventions do not (only) affect HRQoL and these other factors also affect overall quality of life. OBJECTIVE: To validate the Spanish translation of the ICECAP-O's capability to measure Health-related quality of life in elderly with dementia who live in nursing homes...
2017: PloS One
https://www.readbyqxmd.com/read/28067085/-correction-of-aphakia-with-the-implantation-of-the-retropupillary-iris-clip-intraocular-artificial-lens
#8
Antal Szabó, András Papp, Ágnes Borbándy, Zsuzsanna D Géhl, Zoltán Zsolt Nagy, Miklós Resch
INTRODUCTION AND AIM: The correction of aphakia might be a challenge for the surgeon. The aim of this study is to describe the authors' experience with the implantation of the retropupillary iris clip intraocular lens. METHOD: Patients between January 2014 and December 2015 were included in the retrospective study. Retropupillary implantation of iris clip intraocular lens VRSA 54 (AMO Advanced Medical Optics, USA) was performed in all cases. The minimum follow up period was three months...
January 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28065847/a-drosophila-model-of-gdap1-function-reveals-the-involvement-of-insulin-signalling-in-the-mitochondria-dependent-neuromuscular-degeneration
#9
Víctor López Del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
Charcot-Marie-Tooth disease is a rare peripheral neuropathy for which there is no specific treatment. Some forms of Charcot-Marie-Tooth are due to mutations in the GDAP1 gene. A striking feature of mutations in GDAP1 is that they have a variable clinical manifestation, according to disease onset and progression, histology and mode of inheritance. Studies in cellular and animal models have revealed a role of GDAP1 in mitochondrial morphology and distribution, calcium homeostasis and oxidative stress. To get a better understanding of the disease mechanism we have generated models of over-expression and RNA interference of the Drosophila Gdap1 gene...
January 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28065734/laparoscopic-roux-en-y-gastric-bypass-in-adolescents-with-severe-obesity-amos-a-prospective-5-year-swedish-nationwide-study
#10
Torsten Olbers, Andrew J Beamish, Eva Gronowitz, Carl-Erik Flodmark, Jovanna Dahlgren, Gustaf Bruze, Kerstin Ekbom, Peter Friberg, Gunnar Göthberg, Kajsa Järvholm, Jan Karlsson, Staffan Mårild, Martin Neovius, Markku Peltonen, Claude Marcus
BACKGROUND: Severe obesity in adolescence is associated with reduced life expectancy and impaired quality of life. Long-term benefits of conservative treatments in adolescents are known to be modest, whereas short-term outcomes of adolescent bariatric surgery are promising. We aimed to compare 5-year outcomes of adolescent surgical patients after Roux-en-Y gastric bypass with those of conservatively treated adolescents and of adults undergoing Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study...
January 5, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28060734/let-7a-regulates-expression-of-%C3%AE-1-adrenoceptors-and-forms-a-negative-feedback-circuit-with-the-%C3%AE-1-adrenoceptor-signaling-pathway-in-chronic-ischemic-heart-failure
#11
Yue Du, Mingyu Zhang, Wei Zhao, You Shu, Ming Gao, Yanan Zhuang, Ti Yang, Wei Mu, Tingting Li, Xin Li, Fei Sun, Zhenwei Pan, Yanjie Lu
BACKGROUND: The aim of the present study was to investigate the role of microRNA (miRNA) let-7a in down-regulation of β1-adrenoceptors (β1-AR) and elucidate the underlying mechanism of chronic ischemia heart failure (CIHF) in rats. METHODS AND RESULTS: CIHF model was established by occlusion of coronary artery for 4 weeks. β1-AR level was obviously down-regulated and let-7a up-regulated in the failing heart 4 weeks after myocardial infarction. Overexpression of let-7a inhibited β1-AR expression in neonatal rat ventricular cells (NRVCs), which was abolished by anti-let-7a antisense inhibitor...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28057830/individual-versus-collective-cognition-in-social-insects
#12
REVIEW
Ofer Feinerman, Amos Korman
The concerted responses of eusocial insects to environmental stimuli are often referred to as collective cognition at the level of the colony. To achieve collective cognition, a group can draw on two different sources: individual cognition and the connectivity between individuals. Computation in neural networks, for example, is attributed more to sophisticated communication schemes than to the complexity of individual neurons. The case of social insects, however, can be expected to differ. This is because individual insects are cognitively capable units that are often able to process information that is directly relevant at the level of the colony...
January 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28057331/retention-prediction-of-low-molecular-weight-anions-in-ion-chromatography-based-on-quantitative-structure-retention-relationships-applied-to-the-linear-solvent-strength-model
#13
Soo Hyun Park, Paul R Haddad, Mohammad Talebi, Eva Tyteca, Ruth I J Amos, Roman Szucs, John W Dolan, Christopher A Pohl
Quantitative Structure-Retention Relationships (QSRRs) represent a popular technique to predict the retention times of analytes, based on molecular descriptors encoding the chemical structures of the analytes. The linear solvent strength (LSS) model relating the retention factor, k to the eluent concentration (log k=a-blog [eluent]), is a well-known and accurate retention model in ion chromatography (IC). In this work, QSRRs for inorganic and small organic anions were used to predict the regression parameters a and b in the LSS model (and hence retention times) for these analytes under a wide range of eluent conditions, based solely on their chemical structures...
December 19, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28057179/biomarqueurs-pr%C3%A3-dictifs-de-r%C3%A3-ponse-aux-traitements-bloquant-les-voies-de-costimulation-inhibitrices
#14
Franck Pagès, Clémence Granier, Amos Kirilovsky, Carine Elsissy, Eric Tartour
Immunotherapies targeting co-inhibitory receptors recently open a new promising approach of cancer treatment. Indeed, an objective clinical response was observed after treatment by anti-CTLA-4 and anti-PD-1 in many indications but the treatment still failed in 70 to 80 % of cases treated. Given the adverse effects and the high cost of these therapies, there is a need for the development of biomarkers. This review focus on potential predictive biomarkers. In peripheral blood, high level of Il-2 soluble receptor at baseline and absence of ICOS+ CD4-T lymphocytes induction may be associated with the absence of clinical response for melanoma patients treated by ipilimumab (anti-CTLA-4)...
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/28056807/evaluating-decontamination-protocols-for-the-isolation-of-mycobacterium-ulcerans-from-swabs
#15
Enid Owusu, Mercy J Newman, Amos Akumwena, Elizabeth Bannerman, Gerd Pluschke
BACKGROUND: Mycobacterium ulcerans (M. ulcerans) is the causative agent of Buruli Ulcer (BU) disease. In order to inhibit the growth of the microbial contaminants during culture of M. ulcerans, it is necessary to decontaminate BU samples with effective chemical agents. This study aimed at investigating some selected chemicals as potential decontamination agents for the isolation of M. ulcerans from swabs. RESULTS: Povidone iodine at 0.5 and 1% exhibited the lowest contamination and recovery rate for microbial contaminants and M...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28056509/organic-letters-update
#16
Amos B Smith
No abstract text is available yet for this article.
January 6, 2017: Organic Letters
https://www.readbyqxmd.com/read/28055336/treatment-persistence-and-hospitalization-rates-among-patients-with-schizophrenia-a-quasi-experiment-to-evaluate-a-patient-information-program
#17
Dominic Pilon, Tony B Amos, Guillaume Germain, Marie-Hélène Lafeuille, Patrick Lefebvre, Carmela J Benson
OBJECTIVE: The effective treatment of schizophrenia requires continuous antipsychotic maintenance therapy. However, poor persistence of treatment is common among patients with schizophrenia. The objective of this study was to compare persistence and hospitalization rates among patients with schizophrenia treated with long-acting injectable (LAI) antipsychotics (i.e., paliperidone palmitate and risperidone) and enrolled in a patient information program (program cohort) with patients treated with oral antipsychotics (OAs) who were not enrolled in a patient information program (nonprogram cohort)...
January 5, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28055178/investigating-the-dendritic-growth-during-full-cell-cycling-of-garnet-electrolyte-in-direct-contact-with-li-metal
#18
Frederic Aguesse, William Manalastas, Lucienne Buannic, Juan Miguel Lopez Del Amo, Gurpreet Singh, Anna Llordes, John A Kilner
All-solid-state batteries including a garnet ceramic as electrolyte are potential candidates to replace the currently used Li-ion technology as they offer safer operation and higher energy storage performances. However, the development of ceramic electrolyte batteries faces several challenges at the electrode / electrolyte interfaces, which need to withstand high current densities to enable competing C-rates. In this work, we investigate the limits of the anode / electrolyte interface in a full cell that includes a Li metal anode, LiFePO4 cathode and a garnet ceramic electrolyte...
January 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28049585/prediction-of-retention-in-hydrophilic-interaction-liquid-chromatography-using-solute-molecular-descriptors-based-on-chemical-structures
#19
Maryam Taraji, Paul R Haddad, Ruth I J Amos, Mohammad Talebi, Roman Szucs, John W Dolan, Christopher A Pohl
Quantitative structure-retention relationship (QSRR) models are developed to predict the retention times of analytes on five hydrophilic interaction liquid chromatography (HILIC) stationary phases (bare silica, amine, amide, diol and zwitterionic), with a view to selecting the most suitable stationary phase(s) for the separation of these analytes. The study was conducted using six β-adrenergic agonists as target analytes. Molecular descriptors were calculated based only on chemical structures optimized using density functional theory...
December 14, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28042875/the-pik3-mtor-dual-inhibitor-bez235-suppresses-proliferation-and-migration-and-reverses-multidrug-resistance-in-acute-myeloid-leukemia
#20
Lan Deng, Ling Jiang, Xiang-Hua Lin, Kuo-Fu Tseng, Yuan Liu, Xing Zhang, Rui-Hong Dong, Zhi-Gang Lu, Xiu-Ju Wang
Aberrant activation of the PI3K/Akt/mTOR pathway contributes to the proliferation of malignant cells, and may confer resistance to chemotherapy in various malignancies, including acute myeloid leukemia (AML). Chemoresistance is the major reason for relapse in AML. RAD001 (everolimus) has been used at d1 and d7 of an induction chemotherapy regimen for AML, which has acceptable toxicity and may improve conventional chemotherapeutic treatment. Dual inhibitors of PI3K and mTOR overcome some of the intrinsic disadvantages of rapamycin and its derivatives...
January 2, 2017: Acta Pharmacologica Sinica
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