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https://www.readbyqxmd.com/read/29226302/international-union-of-immunological-societies-2017-primary-immunodeficiency-diseases-committee-report-on-inborn-errors-of-immunity
#1
Capucine Picard, H Bobby Gaspar, Waleed Al-Herz, Aziz Bousfiha, Jean-Laurent Casanova, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Kathleen E Sullivan
Beginning in 1970, a committee was constituted under the auspices of the World Health Organization (WHO) to catalog primary immunodeficiencies. Twenty years later, the International Union of Immunological Societies (IUIS) took the remit of this committee. The current report details the categorization and listing of 354 (as of February 2017) inborn errors of immunity. The growth and increasing complexity of the field have been impressive, encompassing an increasing variety of conditions, and the classification described here will serve as a critical reference for immunologists and researchers worldwide...
December 11, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29226301/the-2017-iuis-phenotypic-classification-for-primary-immunodeficiencies
#2
Aziz Bousfiha, Leïla Jeddane, Capucine Picard, Fatima Ailal, H Bobby Gaspar, Waleed Al-Herz, Talal Chatila, Yanick J Crow, Charlotte Cunningham-Rundles, Amos Etzioni, Jose Luis Franco, Steven M Holland, Christoph Klein, Tomohiro Morio, Hans D Ochs, Eric Oksenhendler, Jennifer Puck, Mimi L K Tang, Stuart G Tangye, Troy R Torgerson, Jean-Laurent Casanova, Kathleen E Sullivan
Since the 1990s, the International Union of Immunological Societies (IUIS) PID expert committee (EC), now called Inborn Errors of Immunity Committee, has published every other year a classification of the inborn errors of immunity. This complete catalog serves as a reference for immunologists and researchers worldwide. However, it was unadapted for clinicians at the bedside. For those, the IUIS PID EC is now publishing a phenotypical classification since 2013, which proved to be more user-friendly. There are now 320 single-gene inborn errors of immunity underlying phenotypes as diverse as infection, malignancy, allergy, auto-immunity, and auto-inflammation...
December 11, 2017: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29222956/demographic-drivers-of-a-refugee-species-large-scale-experiments-guide-strategies-for-reintroductions-of-hirola
#3
Abdullahi H Ali, Matthew J Kauffman, Rajan Amin, Amos Kibara, Juliet King, David Mallon, Charles Musyoki, Jacob R Goheen
Effective reintroduction strategies require accurate estimates of vital rates and the factors that influence them. The hirola (Beatragus hunteri) is the rarest antelope on Earth, with a global population size of <500 individuals restricted to the Kenya-Somali border. We estimated vital rates of hirola populations exposed to varying levels of predation and rangeland quality from 2012 to 2015, and then built population matrices to estimate the finite rate of population change (λ) and demographic sensitivities...
December 9, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29220432/triage-by-ranking-to-support-the-curation-of-protein-interactions
#4
Luc Mottin, Emilie Pasche, Julien Gobeill, Valentine Rech de Laval, Anne Gleizes, Pierre-André Michel, Amos Bairoch, Pascale Gaudet, Patrick Ruch
http://candy.hesge.ch/nextA5.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29216183/presentation-of-life-threatening-invasive-nontyphoidal-salmonella-disease-in-malawian-children-a-prospective-observational-study
#5
Calman A MacLennan, Chisomo L Msefula, Esther N Gondwe, James J Gilchrist, Paul Pensulo, Wilson L Mandala, Grace Mwimaniwa, Meraby Banda, Julia Kenny, Lorna K Wilson, Amos Phiri, Jenny M MacLennan, Elizabeth M Molyneux, Malcolm E Molyneux, Stephen M Graham
Nontyphoidal Salmonellae commonly cause invasive disease in African children that is often fatal. The clinical diagnosis of these infections is hampered by the absence of a clear clinical syndrome. Drug resistance means that empirical antibiotic therapy is often ineffective and currently no vaccine is available. The study objective was to identify risk factors for mortality among children presenting to hospital with invasive Salmonella disease in Africa. We conducted a prospective study enrolling consecutive children with microbiologically-confirmed invasive Salmonella disease admitted to Queen Elizabeth Central Hospital, Blantyre, in 2006...
December 7, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29212509/incremental-cost-and-cost-effectiveness-of-low-dose-high-frequency-training-in-basic-emergency-obstetric-and-newborn-care-as-compared-to-status-quo-part-of-a-cluster-randomized-training-intervention-evaluation-in-ghana
#6
Michelle Willcox, Heather Harrison, Amos Asiedu, Allyson Nelson, Patricia Gomez, Amnesty LeFevre
BACKGROUND: Low-dose, high-frequency (LDHF) training is a new approach best practices to improve clinical knowledge, build and retain competency, and transfer skills into practice after training. LDHF training in Ghana is an opportunity to build health workforce capacity in critical areas of maternal and newborn health and translate improved capacity into better health outcomes. METHODS: This study examined the costs of an LDHF training approach for basic emergency obstetric and newborn care and calculates the incremental cost-effectiveness of the LDHF training program for health outcomes of newborn survival, compared to the status quo alternative of no training...
December 6, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29212055/indoor-and-outdoor-air-concentrations-of-volatile-organic-compounds-and-no2-in-schools-of-urban-industrial-and-rural-areas-in-central-southern-spain
#7
Florentina Villanueva, Araceli Tapia, Sonia Lara, Mariano Amo-Salas
Thirty two VOCs including alkanes, aromatic hydrocarbons, terpenes and carbonyl compounds together with NO2 were investigated in a kindergarten classroom, a primary classroom and the playground in 18 schools located in rural areas, an urban area (Ciudad Real) and an industrial area (Puertollano) in the province of Ciudad Real in central southern Spain. The most abundant pollutants at schools were the aldehydes formaldehyde and hexanal. After carbonyls, n-dodecane was the most abundant compound in the study areas...
December 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29211779/correction-human-alpha-defensin-5-is-a-candidate-biomarker-to-delineate-inflammatory-bowel-disease
#8
Amanda D Williams, Olga Y Korolkova, Amos M Sakwe, Timothy M Geiger, Samuel D James, Roberta L Muldoon, Alan J Herline, J Shawn Goodwin, Michael G Izban, Mary K Washington, Duane T Smoot, Billy R Ballard, Maria Gazouli, Amosy E M'Koma
[This corrects the article DOI: 10.1371/journal.pone.0179710.].
2017: PloS One
https://www.readbyqxmd.com/read/29210404/silica-layered-double-hydroxide-core-shell-hybrid-materials
#9
Wing L J Kwok, Dana-Georgiana Crivoi, Chunping Chen, Jean-Charles Buffet, Dermot O'Hare
A series of silica@layered double hydroxides (SiO2@Mg2Al-CO3-AMO-LDHs) have been synthesised by in situ precipitation of Mg2Al-CO3-LDH at room temperature in the presence of amorphous spherical silica particles (∼500 nm). We have systematically investigated a number of synthetic parameters in order to evaluate their effects on the composition, morphological and physical properties of the isolated materials. Syntheses carried out at moderate stirring speeds (e.g. 500 rpm) were found to promote the formation of vertically aligned LDH platelets with respect to the silica surface...
December 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29208631/the-drosophila-junctophilin-gene-is-functionally-equivalent-to-its-four-mammalian-counterparts-and-is-a-modifier-of-a-huntingtin-poly-q-expansion-and-the-notch-pathway
#10
Eduardo Calpena, Víctor López Del Amo, Mouli Chakraborty, Beatriz Llamusí, Rubén Artero, Carmen Espinós, Máximo I Galindo
Members of the Junctophilin (JPH) protein family have emerged as key actors in all excitable cells with critical implications for human pathophysiology. In mammals this family consists in four members (JPH1-4) that are differentially expressed throughout excitable cells. The analysis of knockout mice lacking JPH subtypes has demonstrated their essential contribution to physiological functions in skeletal and cardiac muscles, and neurons. Moreover, mutations in the human JPH2 gene are associated with hypertrophic and dilated cardiomyopathies; mutations in JPH3 are responsible for the neurodegenerative Huntington's disease-like-2 (HDL2), whereas JPH1 acts as a genetic modifier in CMT2K peripheral neuropathy...
November 20, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29206567/comparison-of-robotic-pyeloplasty-and-standard-laparoscopic-pyeloplasty-in-infants-a-bi-institutional-study
#11
Amos Neheman, Eyal Kord, Amnon Zisman, Abd Elhalim Darawsha, Paul H Noh
PURPOSE: To compare outcomes between robotic pyeloplasty (RP) and standard laparoscopic pyeloplasty (LP) in the infant population for the treatment of ureteropelvic junction (UPJ) obstruction. MATERIALS AND METHODS: We performed a retrospective cohort study of all children under 1 year of age who underwent RP or LP at two different medical centers between October 2009 and February 2016. Patient demographics, perioperative data, complications, and results were reviewed...
December 5, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29203594/responding-to-a-community-s-concern-a-comparison-of-breast-cancer-characteristics-and-initial-treatment-in-three-selected-north-carolina-counties
#12
Anissa I Vines, William R Carpenter, Ronald C Chen, Michele W Cherry, Debra G Long, Keith D Amos, Paul A Godley
BACKGROUND A 2007 national report identified North Carolina's Edgecombe County as having among the highest breast cancer incidence and mortality rates nationally, motivating the initiation of a task force and other local efforts to address the problem. The goal of this study is to examine county breast cancer characteristics before and after the report, including whether geographic variation may mask racial disparities in this majority African American community.METHOD With guidance from community partners, breast cancer cases from 2000 to 2012 in Edgecombe, Nash, and Orange Counties (N = 2,641) were obtained from the North Carolina Central Cancer Registry...
November 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/29202097/targeted-community-based-interventions-improved-malaria-management-competencies-in-rural-ghana
#13
Isabella A Quakyi, George O Adjei, David J Sullivan, Judith K Stephens, Amos Laar, Vivian N Ama Aubyn, Richmond Owusu, Kwame S Sakyi, Nathaniel Coleman, Francis D Krampa, Linda Vanotoo, Julliette Tuakli, Bernard B Bortei, Edward Essuman, Felix Sorvor, Isaac A Boateng, Constance Bart-Plange, Ebenezer A Addison, Peter Winch, Andrew A Adjei
Background: Malaria is one of the most challenging public health concerns in the developing world. To address its impact in endemic regions, several interventions are implemented by stakeholders. The Affordable Medicine Facility-malaria (AMFm) is an example of such interventions. Its activities include communication interventions to enhance the knowledge of caregivers of children under five years, licensed chemical sellers (LCS) and prescribers on malaria management with artemisinin-based combination therapy (ACT)...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29197279/trends-in-the-consecutive-days-of-temperature-and-precipitation-extremes-in-china-during-1961-2015
#14
Jun Shi, Linli Cui, Kangmin Wen, Zhan Tian, Peipei Wei, Bowen Zhang
BACKGROUND AND AIMS: Consecutive climatic extremes have more intense impacts on natural ecosystems and human activities than occasional events. There were many studies about the frequency or intensity of extreme weather events, but few focused on the consecutiveness or continuousness of climatic extremes. We analyzed the temporal and spatial distributions and tendencies in the consecutive temperature and precipitation extremes in China during 1961-2015. METHODS: Daily temperature and precipitation data at 1867 meteorological stations over China was used and four consecutive indices of climate extremes, i...
November 29, 2017: Environmental Research
https://www.readbyqxmd.com/read/29193808/molecular-epidemiological-characterization-of-brucella-isolates-from-sheep-and-yaks-in-northwest-china
#15
X Cao, Z Li, Z Liu, B Fu, Y Liu, Y Shang, J Zhou, Z Jing
Animal brucellosis is a re-emerging disease in China with high prevalence in the northwest region. A total of 66 isolates of Brucella were recovered from sheep and yaks in the Inner Mongolia, Xinjiang, Qinghai and Gansu provinces of northwest China in 2015 and 2016. Using classical biotyping and the Brucella AMOS PCR assay, all isolates were identified as Brucella melitensis biovar 3 (n = 58), B. melitensis biovar 1 (n = 1), Brucella abortus (n = 5), or Brucella suis biovar 3 (n = 2), and B. melitensis biovar 3 was found to be mainly responsible for sheep brucellosis in northwest China...
November 29, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29191990/correction-for-fricke-et-al-human-cytosolic-extracts-stabilize-the-hiv-1-core
#16
Thomas Fricke, Alberto Brandariz-Nuñez, Xiaozhao Wang, Amos B Smith, Felipe Diaz-Griffero
No abstract text is available yet for this article.
December 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29189755/study-of-optical-fiber-sensors-for-cryogenic-temperature-measurements
#17
Veronica De Miguel-Soto, Daniel Leandro, Aitor Lopez-Aldaba, Juan Jesus Beato-López, José Ignacio Pérez-Landazábal, Jean-Louis Auguste, Raphael Jamier, Philippe Roy, Manuel Lopez-Amo
In this work, the performance of five different fiber optic sensors at cryogenic temperatures has been analyzed. A photonic crystal fiber Fabry-Pérot interferometer, two Sagnac interferometers, a commercial fiber Bragg grating (FBG), and a π-phase shifted fiber Bragg grating interrogated in a random distributed feedback fiber laser have been studied. Their sensitivities and resolutions as sensors for cryogenic temperatures have been compared regarding their advantages and disadvantages. Additionally, the results have been compared with the given by a commercial optical backscatter reflectometer that allowed for distributed temperature measurements of a single mode fiber...
November 30, 2017: Sensors
https://www.readbyqxmd.com/read/29188914/-vernakalant-in-hospital-emergency-practice-safety-and-effectiveness
#18
José Carbajosa Dalmau, Juan Cosín-Sales, María José Pérez-Durá, José Noceda, Amós Urtubia-Palacios, Néstor Hernández-Sori, Ana Peiró-Gómez, Javier Jacob, Pere Llorens, Luis Ruescas-Gómez, Alfonso Martín-Martínez
OBJECTIVES: To study the effectiveness and safety of vernakalant for restoration of sinus rhythm in patients with atrial fibrillation (AF) in routine hospital emergency department care, and to evaluate factors associated with a more effective response. MATERIAL AND METHODS: Prospective multicenter cohort study enrolling consecutive patients who were administered vernakalant for medical cardioversion of AF between September 2014 through March 2016 in 5 hospitals in the Spanish autonomous community of Valencia...
2017: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29185282/the-lived-experience-of-parkinson-s-disease-a-content-analysis-of-parkinson-s-patients-blogs
#19
Amy L Shapira, Ruth Handzel, Amos D Korczyn
BACKGROUND: Blogs have become a major venue of information sharing and emotional release for people worldwide. Illness blogs are a specific type of blog in which patients describe their experience with illness and coping with disease. Illness blog research has been conducted on several disorders; however, blogs by Parkinson's disease (PD) patients have been neglected. OBJECTIVES: To categorize the characteristics of PD patients from blogs and explore whether we can learn about the medical issues with which they are most concerned, as conveyed through their blog posts...
November 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29184545/comparison-of-the-effects-of-phenylhydrazine-hydrochloride-and-dicyandiamide-on-ammonia-oxidizing-bacteria-and-archaea-in-andosols
#20
Wenjie Yang, Yong Wang, Kanako Tago, Shinichi Tokuda, Masahito Hayatsu
Dicyandiamide, a routinely used commercial nitrification inhibitor (NI), inhibits ammonia oxidation catalyzed by ammonia monooxygenase (AMO). Phenylhydrazine hydrochloride has shown considerable potential for the development of next-generation NIs targeting hydroxylamine dehydrogenase (HAO). The effects of the AMO inhibitor and the HAO inhibitor on ammonia-oxidizing bacteria (AOB) and ammonia-oxidizing archaea (AOA) present in agricultural soils have not been compared thus far. In the present study, the effects of the two inhibitors on soil nitrification and the abundance of AOA and AOB as well as their community structure were investigated in a soil microcosm using quantitative polymerase chain reaction and pyrosequencing...
2017: Frontiers in Microbiology
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