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https://www.readbyqxmd.com/read/29677555/matrix-architecture-plays-a-pivotal-role-in-3d-osteoblast-migration-the-effect-of-interstitial-fluid-flow
#1
Cristina Del Amo, Vanesa Olivares, Mar Cóndor, Alejandro Blanco, Jorge Santolaria, Jesús Asín, Carlos Borau, José Manuel García-Aznar
Osteoblast migration is a crucial process in bone regeneration, which is strongly regulated by interstitial fluid flow. However, the exact role that such flow exerts on osteoblast migration is still unclear. To deepen the understanding of this phenomenon, we cultured human osteoblasts on 3D microfluidic devices under different fluid flow regimes. Our results show that a slow fluid flow rate by itself is not able to alter the 3D migratory patterns of osteoblasts in collagen-based gels but that at higher fluid flow rates (increased flow velocity) may indirectly influence cell movement by altering the collagen microstructure...
April 10, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#2
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29675505/locking-dorsal-plate-in-four-bone-arthrodesis-in-slac-and-snac-3-wrist
#3
Simona Odella, Amos M Querenghi, Francesco M Locatelli, Ugo Dacatra, Elia Creta, Pierluigi Tos
Purpose  The aim of this study was to evaluate the effectiveness and the safety of performing a four-bone arthrodesis (FBA) with dorsal locking plate in patients suffering from stage III scapholunate advanced collapse/scaphoid nonunion advance collapse (SLAC/SNAC) wrist. Methods  We evaluated retrospectively 20 patients surgically treated by a FBA with the use of locking dorsal plate. All the patients were clinically evaluated at follow-up for grip strength, range of motion, and pain (visual analog scale), and with the Disability of the Arm, Shoulder and Hand score and the Mayo wrist score...
March 2018: Joints
https://www.readbyqxmd.com/read/29672172/ongoing-initiatives-to-improve-the-use-of-antibiotics-in-botswana-university-of-botswana-symposium-meeting-report
#4
Celda Tiroyakgosi, Matshediso Matome, Emily Summers, Yohana Mashalla, Bene Anand Paramadhas, Sajini Souda, Brighid Malone, Fatima Sinkala, Joyce Kgatlwane, Brian Godman, Keneilwe Mmopi, Amos Massele
The objective of this meeting was to discuss ongoing initiatives in Botswana since February 2016 to improve antibiotic use. Subsequently, use the findings to refine national and local action plans. There was a high rate of antibiotic prescribing among ambulatory care patients in the public sector (42.7%) as well as for patients with URTIs in the private sector (72.9%). Prophylactic antibiotics were given to 73.3% of surgical patients to reduce surgical site infections (SSIs) in a leading tertiary hospital in Botswana; however, SSIs at 9% of patients can be reduced further with better timing of antibiotic prophylaxis...
April 19, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29664687/distinctiveness-and-similarities-between-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-isolated-from-cattle-and-the-community-in-israel
#5
Ziv Lifshitz, Na'ama Sturlesi, Miriam Parizade, Shlomo E Blum, Michal Gordon, Diana Taran, Amos Adler
The goal of this study was to compare the molecular features of bovine- and human community-acquired extended-spectrum β-lactamase (ESBL)-producing Escherichia coli in Israel. Bovine ESBL-producing E. coli were isolated during a point-prevalence study from the main farming locations throughout Israel. Human ESBL-producing E. coli isolates were collected from community-acquired urinary tract infection cases. Molecular typing was done initially by repetitive extragenic palindromic-PCR. Representative isolates were subjected to next-generation sequencing (NGS) and analyzed for multilocus sequence typing (MLST), core genome MLST (cgMLST), blaCTX-M gene allele, and mobile genetic elements (MGEs) surrounding it...
April 17, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29664119/e-cigarettes-vaping-and-performativity-in-the-context-of-tobacco-denormalisation
#6
Mark Lucherini, Catriona Rooke, Amanda Amos
E-cigarettes are devices through which a nicotine solution is 'vapourised' and inhaled by the user. Unlike cigarettes, the process involves no tobacco combustion. However, the inhalation and exhalation of vapour is reminiscent of smoking and there is debate about the possible harms and benefits of e-cigarette use, including the 'renormalisation' of smoking. Despite these debates, there has been little exploration into the embodied and semiotic similarities between smoking and vaping. This paper views the practices of vaping and smoking through the lens of performativity that is, the accumulation of meaning associated with the habits over time and space...
April 17, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29662090/optical-interrogation-of-neuronal-circuitry-in-zebrafish-using-genetically-encoded-voltage-indicators
#7
Hiroaki Miyazawa, Kanoko Okumura, Kanae Hiyoshi, Kazuhiro Maruyama, Hisaya Kakinuma, Ryunosuke Amo, Hitoshi Okamoto, Kyo Yamasu, Sachiko Tsuda
Optical measurement of membrane potentials enables fast, direct and simultaneous detection of membrane potentials from a population of neurons, providing a desirable approach for functional analysis of neuronal circuits. Here, we applied recently developed genetically encoded voltage indicators, ASAP1 (Accelerated Sensor of Action Potentials 1) and QuasAr2 (Quality superior to Arch 2), to zebrafish, an ideal model system for studying neurogenesis. To achieve this, we established transgenic lines which express the voltage sensors, and showed that ASAP1 is expressed in zebrafish neurons...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29660353/serious-cover-up-hodgkin-s-lymphoma-masked-by-organizing-pneumonia
#8
Amos Lal, Michael J Davis, Jamal Akhtar, Yayan Chen, Steven Davis
No abstract text is available yet for this article.
April 13, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29659059/high-electrical-conductivity-of-single-metal-organic-chains
#9
Pablo Ares, Pilar Amo-Ochoa, José M Soler, Juan José Palacios, Julio Gómez-Herrero, Félix Zamora
Molecular wires are essential components for future nanoscale electronics. However, the preparation of individual long conductive molecules is still a challenge. MMX metal-organic polymers are quasi-1D sequences of single halide atoms (X) bridging subunits with two metal ions (MM) connected by organic ligands. They are excellent electrical conductors as bulk macroscopic crystals and as nanoribbons. However, according to theoretical calculations, the electrical conductance found in the experiments should be even higher...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29658207/ablation-induced-change-in-the-course-of-fascicular-tachycardia
#10
Avishag Laish-Farkash, Avi Sabbag, Michael Glikson, Aharon Glick, Vladimir Khalameizer, Amos Katz, Yoav Michowitz
BACKGROUND: Multiform fascicular tachycardia (FT) was recently described as a ventricular tachycardia (VT) that has a reentrant mechanism using multiple fascicular branches and produces alternate fascicular VT forms. Ablating the respective fascicle may cause a change in the reentrant circuit resulting in a change in morphology. Ablation of the septal fascicle is crucial for successful treatment. OBJECTIVES: To describe four cases of FT in which ablation induced a change in QRS morphologies and aggravated clinical course...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29657167/let-me-hold-the-wheel-daddy
#11
Amos Ritter
No abstract text is available yet for this article.
2018: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29651744/prospects-of-chimeric-antigen-receptor-t-cell-therapy-in-ovarian-cancer
#12
REVIEW
Vishal Jindal, Ena Arora, Sorab Gupta, Amos Lal, Muhammad Masab, Rashmika Potdar
Despite advances in various chemotherapy regimens, current therapeutic options are limited for ovarian cancer patients. Immunotherapy provides a promising and novel treatment option for ovarian cancer. Recently, chimeric antigen receptor (CAR) T cell therapy has shown promising results in hematological tumors and current research is going on in various solid tumors like ovarian cancer. CAR T cells are genetically engineered T cells with major histocompatibility complex-independent, tumor-specific, immune-mediated cytolytic actions against cancer cells...
April 12, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29643534/-in-vivo-imaging-of-breast-tumors-by-a-99m-tc-radiolabeled-probe-targeting-microrna-155-in-mice-models
#13
L Kang, Y Huo, R F Wang, C L Zhang, P Yan, X J Xu
OBJECTIVE: MicroRNA-155 (miR-155) is significantly highly expressed in breast cancer, lung cancer, liver cancer and other malignant tumors. This study was to design and construct a radiolabeled probe targeting miR-155 for in vivo imaging in breast cancer. METHODS: Anti-miR-155 oligonucleotide (AMO-155) was chemically synthesized with 2' OMe modification. Its 5' end was linked with acetyl amine group. After chelated with a bifunctional chelator NHS-MAG3, AMO-155 was radiolabeled with 99m Tc using stannous chloride...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29642467/proton-partial-breast-irradiation-detailed-description-of-acute-clinico-radiologic-effects
#14
Valentina Ovalle, Eric A Strom, Simona Shaitelman, Karen Hoffman, Richard Amos, George Perkins, Welela Tereffe, Benjamin D Smith, Michael Stauder, Wendy Woodward
Introduction: Accelerated partial breast irradiation (APBI) with protons results in a very different acute effect profile than standard whole breast irradiation. We reviewed our initial experience with proton APBI and felt that a detailed description of these effects were needed to permit a common tool to compare experience with this developing technology. Methods: Sixty sequential patients treated with proton APBI on a prospective protocol were evaluated and 43 patients with a minimum six-month follow-up underwent detailed photographic and radiologic analysis...
April 7, 2018: Cancers
https://www.readbyqxmd.com/read/29629731/the-effect-of-mineralocorticoid-receptor-antagonists-on-recruitment-and-function-of-endothelial-progenitor-cells-in-patients-with-congestive-heart-failure
#15
Amos Levi, Dorit Leshem-Lev, Adaya Weissler-Snir, Tal Hasin, Israel Mats, Daniel Murninkas, Ran Kornowski, Eli I Lev, Tuvia Ben-Gal
BACKGROUND: Circulating endothelial progenitor cells have an important role in the process of vascular repair. Impaired recruitment and function of endothelial progenitor cells is related to the pathophysiology of congestive heart failure. Endothelial progenitor cells have been shown to express the mineralocorticoid receptor. OBJECTIVES: To investigate the effect of mineralocorticoid receptor antagonists on endothelial progenitor cells in patients with heart failure...
April 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29627951/risk-factors-for-recurrent-clostridium-difficile-infection-in-a-tertiary-hospital-in-israel
#16
Wasef Na'amnih, Amos Adler, Tamar Miller-Roll, Dani Cohen, Yehuda Carmeli
To estimate the rate and identified risk factors for recurrent Clostridium difficile infection (rCDI) in Israel. We conducted a retro-prospective case-control study of all adult (age ≥ 18 years) patients with an initial episode of CDI (iCDI) at Tel Aviv Sourasky Medical Center from January 1, 2012 to December 31, 2014. We collected demographic, clinical, and epidemiological information for patients who were classified as recurrent (cases) and non-recurrent (control) groups. In total, 648 patients with iCDI were identified in the study...
April 7, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29625623/facilitators-and-barriers-to-the-delivery-of-school-based-smoking-prevention-interventions-for-children-and-young-people-a-protocol-for-a-systematic-review-of-qualitative-studies
#17
Fiona Dobbie, Kathryn Angus, Hannah Littlecott, Karen Allum, Valerie Wells, Amanda Amos, Sally Haw, Linda Bauld
BACKGROUND: Despite a decline in child and adult smoking prevalence, young people who smoke (even occasionally) can rapidly become addicted to nicotine, with most adult smokers initiating smoking before they are 18. Schools have long been a popular setting to deliver youth smoking prevention interventions, but evidence of the effectiveness of school-based prevention programmes is mixed, and outcomes vary by the type of programme delivered. Existing systematic reviews that explore the factors contributing to the success or failure of school-based smoking prevention programmes often exclude qualitative studies, due to a focus on intervention effectiveness which qualitative research cannot answer...
April 6, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29625211/corneal-and-conjunctival-drug-permeability-systematic-comparison-and-pharmacokinetic-impact-in-the-eye
#18
Eva Ramsay, Eva M Del Amo, Elisa Toropainen, Unni Tengvall-Unadike, Veli-Pekka Ranta, Arto Urtti, Marika Ruponen
On the surface of the eye, both the cornea and conjunctiva are restricting ocular absorption of topically applied drugs, but barrier contributions of these two membranes have not been systemically compared. Herein, we studied permeability of 32 small molecular drug compounds across an isolated porcine cornea and built a quantitative structure-property relationship (QSPR) model for the permeability. Corneal drug permeability (data obtained for 25 drug molecules) showed a 52-fold range in permeability (0.09-4...
April 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29621832/identifying-associations-between-somatic-mutations-and-clinicopathologic-findings-in-lung-cancer-pathology-reports
#19
Nishant Kumar, Laura J Tafe, John H Higgins, Jason D Peterson, Francise Blumental de Abreu, Sophie J Deharvengt, Gregory J Tsongalis, Christopher I Amos, Saeed Hassanpour
OBJECTIVE: We aim to build an informatics methodology capable of identifying statistically significant associations between the clinical findings of non-small cell lung cancer (NSCLC) recorded in patient pathology reports and the various clinically actionable genetic mutations identified from next-generation sequencing (NGS) of patient tumor samples. METHODS: We built an information extraction and analysis pipeline to identify the associations between clinical findings in the pathology reports of patients and corresponding genetic mutations...
February 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29618955/content-is-king-databases-preserve-the-collective-information-of-science
#20
John R Yates
Databases store sequence information experimentally gathered to create resources that further science. In the last 20 years databases have become critical components of fields like proteomics where they provide the basis for large-scale and high-throughput proteomic informatics. Amos Bairoch, winner of the Association of Biomolecular Resource Facilities Frederick Sanger Award, has created some of the important databases proteomic research depends upon for accurate interpretation of data.
March 22, 2018: Journal of Biomolecular Techniques: JBT
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