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https://www.readbyqxmd.com/read/29452393/no-copper-supplementation-in-a-corn-soybean-basal-diet-has-no-adverse-effects-on-late-phase-laying-hens-under-normal-and-cyclic-high-temperatures
#1
W X Li, Y Q Chen, L H Zhao, Q G Ma, J Y Zhang, C Ji
Over supplementation of copper (Cu) in animal diets may cause serious pollution in soil, water and harvested crops. To minimize the potential pollution, the effects of corn-soybean basal diet with or without supplementation of 8 mg Cu/kg on laying performance, plasma biochemical metabolic indices, and antioxidant status in laying hens were evaluated under normal and cyclic high temperatures. A total of 240 Hy-Line Brown laying hens were randomly allotted to 4 treatments with 6 replicates of 10 hens per replicate according to factorial design involved in 2 temperatures [normal temperature (NT) vs...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452392/pbrit-gene-prioritization-by-correlating-functional-and-phenotypic-annotations-through-integrative-data-fusion
#2
Ajay Anand Kumar, Lut Van Laer, Maaike Alaerts, Amin Ardeshirdavani, Yves Moreau, Kris Laukens, Bart Loeys, Geert Vandeweyer, Inanc Birol
Motivation: Computational gene prioritization can aid in disease gene identification. Here, we propose pBRIT (prioritization using Bayesian Ridge regression and Information Theoretic model), a novel adaptive and scalable prioritization tool, integrating Pubmed abstracts, Gene Ontology, Sequence similarities, Mammalian and Human Phenotype Ontology, Pathway, Interactions, Disease Ontology, Gene Association database and Human Genome Epidemiology database, into the prediction model.We explore and address effects of sparsity and inter-feature dependencies within annotation sources, and the impact of bias towards specific annotations...
February 14, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29452293/genetic-diversity-and-functional-analysis-of-oipa-gene-in-association-with-other-virulence-factors-among-helicobacter-pylori-isolates-from-iranian-patients-with-different-gastric-diseases
#3
Nastaran Farzi, Abbas Yadegar, Hamid Asadzadeh Aghdaei, Yoshio Yamaoka, Mohammad Reza Zali
Helicobacter pylori (H. pylori) is one of the most genetically diverse bacterial pathogens that persistently colonizes the human gastric epithelium. This remarkable genomic plasticity may act as a driving force for successful adaptation and persistence of the bacteria in the harsh gastric environment. Outer inflammatory protein A (OipA) encoded by oipA gene (HP0638/hopH) is a member of the outer membrane proteins (OMPs) of H. pylori involved in induction of IL-8 secretion and is associated with development of peptic ulcer and gastric cancer...
February 13, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29452290/lean-body-weight-is-the-best-scale-for-venous-thromboprophylaxis-algorithm-in-severely-obese-patients-undergoing-bariatric-surgery
#4
Bénédicte Gaborit, Pierre-Antoine Moulin, Thierry Bege, Sandrine Boullu, Clara Vincentelli, Olivier Emungania, Pierre-Emmanuel Morange, Stéphane Berdah, Joe-Elie Salem, Anne Dutour, Corinne Frere
Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size descriptors (BSD) on peak anti-Xa levels in BS obese patients receiving LMWH fixed doses to identify which one had the greatest impact. One hundred and thirteen BS obese patients [median body mass index (BMI), 43...
February 13, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29452288/repetitive-tlr-3-activation-in-the-lung-induces-skeletal-muscle-adaptations-and-cachexia
#5
Ted G Graber, Brandy L Rawls, Bing Tian, William J Durham, Camille R Brightwell, Allan R Brasier, Blake B Rasmussen, Christopher S Fry
Due to immunosenescence, older adults are particularly susceptible to lung-based viral infections, with increased severity of symptoms in those with underlying chronic lung disease. Repeated respiratory viral infections produce lung maladaptations, accelerating pulmonary dysfunction. Toll like 3 receptor (TLR3) is a membrane protein that senses exogenous double-stranded RNA to activate the innate immune response to a viral infection. Polyinosinic-polycytidylic acid [poly(I:C)] mimics double stranded RNA and has been shown to activate TLR3...
February 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29452266/healthy-brain-aging-interplay-between-reactive-species-inflammation-and-energy-supply
#6
REVIEW
O Garaschuk, H M Semchyshyn, V I Lushchak
Brains' high energy expenditure with preferable utilization of glucose and ketone bodies, defines the specific features of its energy homeostasis. The extensive oxidative metabolism is accompanied by a concomitant generation of high amounts of reactive oxygen, nitrogen, and carbonyl species, which will be here collectively referred to as RONCS. Such metabolism in combination with high content of polyunsaturated fatty acids creates specific problems in maintaining brains' redox homeostasis. While the levels of products of interaction between RONCS and cellular components increase slowly during the first two trimesters of individuals' life, their increase is substantially accelerated towards the end of life...
February 13, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29452258/recent-findings-related-to-immune-responses-against-leptospirosis-and-novel-strategies-to-prevent-infection
#7
Frédérique Vernel-Pauillac, Catherine Werts
What are the new approaches and emerging ideas to prevent leptospirosis, a neglected bacterial re-emerging zoonotic disease? How do Leptospira interrogans escape the host defenses? We aim here to review and discuss the most recent literature that provides some answers to these questions, in particular data related to a better understanding of adaptive and innate immunity towards leptospires, and design of vaccines. This is an opinion paper, not a comprehensive review. We will try to highlight the new strategies and technologies boosting the search for drugs and vaccines...
February 13, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29452237/a-redox-sensitive-signaling-pathway-mediates-pro-angiogenic-effect-of-chlordecone-via-estrogen-receptor-activation
#8
Eid Alabed Alibrahim, Ramaroson Andriansitohaina, Kévin Hardonnière, Raffaella Soleti, Sébastien Faure, Gilles Simard
AIM: Chlordecone is able to induce pro-angiogenic effect through an estrogen receptor (ERα) pathway involving NO release and VEGF. The present study aimed to determine the molecular mechanisms by which chlordecone promotes angiogenesis in human endothelial cells. RESULTS: High but not low concentration of chlordecone increased mitochondrial respiratory capacity and mitochondrial DNA content in endothelial cells. The ROS scavenger MnTMPyP was able to prevent the increase of both VEGF expression and capillary length induced by chlordecone...
February 13, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29452228/a-bach2-gene-variant-is-associated-with-postoperative-recurrence-of-crohn-s-disease
#9
Michael R Laffin, Richard N Fedorak, Eytan Wine, Bryan Dicken, Karen L Madsen
BACKGROUND: Crohn's disease often requires intestinal resection, which is not considered curative. Repeat surgical intervention is necessary in over half of the patients following their initial operation. Although many genetic loci are implicated in Crohn's disease, few have been associated with post-resection recurrence. STUDY DESIGN: A cohort of Crohn's disease subjects who underwent intestinal resection was analyzed to determine genetic and clinical factors associated with post-resection recurrence...
February 13, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29452053/social-adjustment-and-repressive-adaptive-style-in-survivors-of-pediatric-cancer
#10
Fiona Schulte, Amanda Wurz, K Brooke Russell, Kathleen Reynolds, Douglas Strother, Deborah Dewey
PURPOSE: The aim of the study was to explore the relationship between repressive adaptive style and self-reports of social adjustment in survivors of pediatric cancer compared to their siblings. We hypothesized that there would be a greater proportion of repressors among survivors of pediatric cancer compared to siblings, and that repressive adaptive style would be significantly associated with more positive self-reports of social adjustment. METHODS: We utilized a cross-sectional approach...
February 16, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29451989/all-done-procedure-by-laser-in-free-gingival-graft-treatment-a-case-series-study
#11
Reza Fekrazad, Nasim Chiniforush, Katayoun Kalhori
AIM: This case series study evaluated the application of Er;Cr:YSGG laser for a free gingival graft procedure and the effect of low level laser therapy on post surgical pain and wound healing. CASES: 6 cases with mucogingival problems needing free gingival grafts were selected. First, the recipient site was anesthetized and de-epithelialization was done with a Er;Cr:YSGG laser. After tracing the palatal donor site with the laser, the graft was harvested. For root modification of the recipient tooth, conditioning of the dentin was done by the same laser...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29451929/natural-tooth-as-the-permanent-reconstruction-after-immediate-implantation-in-the-esthetic-zone-of-periodontally-compromised-patients
#12
Nejat Nizam, Aliye Akcalı
This case series describes a treatment method in which the natural tooth was used as the temporary and permanent reconstruction after immediate implantation in the esthetic zone of periodontally compromised patients. Five patients with a hopeless tooth in the esthetic zone due to periodontal causes were included. The tooth was extracted, and immediate implantation protocol was followed. The extracted tooth was adapted over a temporary abutment during the osseointegration period, and the same tooth served as the final prosthetic reconstruction with a customized zirconia abutment...
February 16, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29451922/identifying-classifier-input-signals-to-predict-a-cross-slope-during-transtibial-amputee-walking
#13
Courtney E Shell, Glenn K Klute, Richard R Neptune
Advanced prosthetic foot designs often incorporate mechanisms that adapt to terrain changes in real-time to improve mobility. Early identification of terrain (e.g., cross-slopes) is critical to appropriate adaptation. This study suggests that a simple classifier based on linear discriminant analysis can accurately predict a cross-slope encountered (0°, -15°, 15°) using measurements from the residual limb, primarily from the prosthesis itself. The classifier was trained and tested offline using motion capture and in-pylon sensor data collected during walking trials in mid-swing and early stance...
2018: PloS One
https://www.readbyqxmd.com/read/29451915/synchronic-historical-patterns-of-species-diversification-in-seasonal-aplocheiloid-killifishes-of-the-semi-arid-brazilian-caatinga
#14
Wilson J E M Costa, Pedro F Amorim, José Leonardo O Mattos
The Caatinga is the largest nucleus of seasonally dry tropical forests in South America, but little is known about the evolutionary history and biogeography of endemic organisms. Evolutionary diversification and distribution of terrestrial vertebrates endemic to the Caatinga have been explained by palaeogeographical Neogene episodes, mostly related to changes in the course of the São Francisco River, the largest river in the region. Our objective is to estimate the timing of divergence of two endemic groups of short-lived seasonal killifishes inhabiting all ecoregions of the Caatinga, testing the occurrence of synchronic events of spatial diversification in light of available data on regional palaeogeography...
2018: PloS One
https://www.readbyqxmd.com/read/29451893/vegetative-compatibility-groups-partition-variation-in-the-virulence-of-verticillium-dahliae-on-strawberry
#15
Rong Fan, Helen M Cockerton, Andrew D Armitage, Helen Bates, Emma Cascant-Lopez, Laima Antanaviciute, Xiangming Xu, Xiaoping Hu, Richard J Harrison
Verticillium dahliae infection of strawberry (Fragaria x ananassa) is a major cause of disease-induced wilting in soil-grown strawberries across the world. To understand what components of the pathogen are affecting disease expression, the presence of the known effector VdAve1 was screened in a sample of Verticillium dahliae isolates. Isolates from strawberry were found to contain VdAve1 and were divided into two major clades, based upon their vegetative compatibility groups (VCG); no UK strawberry isolates contained VdAve1...
2018: PloS One
https://www.readbyqxmd.com/read/29451888/ecogeography-of-teosinte
#16
José de Jesús Sánchez González, José Ariel Ruiz Corral, Guillermo Medina García, Gabriela Ramírez Ojeda, Lino De la Cruz Larios, James Brendan Holland, Roberto Miranda Medrano, Giovanni Emmanuel García Romero
Adaptation of crops to climate change has motivated an increasing interest in the potential value of novel traits from wild species; maize wild relatives, the teosintes, harbor traits that may be useful to maize breeding. To study the ecogeographic distribution of teosinte we constructed a robust database of 2363 teosinte occurrences from published sources for the period 1842-2016. A geographical information system integrating 216 environmental variables was created for Mexico and Central America and was used to characterize the environment of each teosinte occurrence site...
2018: PloS One
https://www.readbyqxmd.com/read/29451873/in-silico-analysis-of-antibiotic-induced-clostridium-difficile-infection-remediation-techniques-and-biological-adaptations
#17
Eric W Jones, Jean M Carlson
In this paper we study antibiotic-induced C. difficile infection (CDI), caused by the toxin-producing C. difficile (CD), and implement clinically-inspired simulated treatments in a computational framework that synthesizes a generalized Lotka-Volterra (gLV) model with SIR modeling techniques. The gLV model uses parameters derived from an experimental mouse model, in which the mice are administered antibiotics and subsequently dosed with CD. We numerically identify which of the experimentally measured initial conditions are vulnerable to CD colonization, then formalize the notion of CD susceptibility analytically...
February 16, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29451833/development-and-pilot-testing-of-a-text-message-vaccine-reminder-system-for-use-during-an-influenza-pandemic
#18
Jonathan D Lehnert, Alex Shevach, Sydney Walker, Rose Wang, Thomas J Fitzgerald, Samuel B Graitcer
In an influenza pandemic, two vaccine doses administered 21 days apart may be needed for individuals of all ages to achieve seroprotection. Achieving dose-series completion can be challenging even for routinely recommended vaccines. To prepare for a two-dose influenza pandemic vaccine campaign and promote dose-series completion and correct dosing intervals, CDC and its partners developed a text message-based vaccine reminder system to remind persons who receive a first dose of pandemic influenza vaccine to receive the second dose...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451795/physisorption-of-h-2-on-fullerenes-and-the-solvation-of-c-60-by-hydrogen-clusters-at-finite-temperature-a-theoretical-assessment
#19
Florent Calvo, Ersin Yurtsever, Adem Tekin
The interaction between hydrogen and carbonaceous nanostructures is of fundamental interest in various areas of physical chemistry. In this contribution we have revisited the physisorption of hydrogen molecules and H2 clusters on fullerenes, following a first-principles approach in which the interaction is quantitatively evaluated for the C20 system using high-level electronic structure methods. Relative to coupled cluster data at the level of single, double, and perturbative triple excitations [CCSD(T)] taken as benchmark, the results for rotationally averaged physisorbed H2 show a good performance of MP2 variants and symmetry-adapted perturbation theory (SAPT), but significant deviations and basis set convergence issues are found for dispersion-corrected density functional theory (DFT)...
February 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29451793/temporary-anion-states-of-ethene-interacting-with-single-molecules-of-methane-ethane-and-water
#20
Thomas Sommerfeld, Joshua B Melugin, Masahiro Ehara
When an excess electron is added into the π* orbital of ethene, the resulting anion decays by electron autodetachment---that is, it represents an electronic state referred to as a temporary anion or resonance state. Here the influence of a cluster environment on the energy and lifetime of this state is investigated. The clusters considered are ethene...CH 4 , ethene...C 2 H 6 , and ethene...H 2 O. Most of these clusters are systematically constructed so that the solvent interacts with the π system in a specific way, and are thus by construction not minima with respect to all intermolecular degrees of freedom...
February 16, 2018: Journal of Physical Chemistry. A
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