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https://www.readbyqxmd.com/read/27847769/clinical-utility-of-angiographic-ct-with-a-flat-detector-angiographic-system-during-endovascular-procedure
#1
Seon Woong Choi, Kwang Wook Jo, Young Woo Kim, Seong Rim Kim, Ik Seong Park, Hoon Kim
OBJECTIVE: We evaluated the feasibility of angiographic computed tomography (ACT) for visualizing stent material in patients who underwent intracranial or extracranial stent placement to treat atherosclerotic lesions or stent assisted coil embolization. MATERIALS AND METHODS: We performed intrarterial and intravenous ACT on biplane angiography system equipped with flat panel detectors (Axiom Arits dBA; Siemens Medical Solutions, Forchheim, Germany). Vistipaque 320 was injected for contrast medium, total 150 mL at flow rate of 5 mL/s through artery and 77 mL at flow rate of 3...
September 2016: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/27812689/association-of-polymorphisms-in-fcgr2a-and-fcgr3a-with-degree-of-trastuzumab-benefit-in-the-adjuvant-treatment-of-erbb2-her2-positive-breast-cancer-analysis-of-the-nsabp-b-31-trial
#2
Patrick G Gavin, Nan Song, S Rim Kim, Corey Lipchik, Nicole L Johnson, Hanna Bandos, Melanie Finnigan, Priya Rastogi, Louis Fehrenbacher, Eleftherios P Mamounas, Sandra M Swain, D Lawrence Wickerham, Charles E Geyer, Jong-Hyeon Jeong, Joseph P Costantino, Norman Wolmark, Soonmyung Paik, Kay L Pogue-Geile
Importance: Preclinical models and studies in the metastatic and neoadjuvant settings suggest that single nucleotide polymorphisms in FCGR3A and FCGR2A may be associated with differential response to trastuzumab in the treatment of ERBB2/HER2-positive breast cancer, by modulating antibody-dependent cell-mediated cytotoxic effects. Objective: To evaluate the effect of FCGR2A and FCGR3A polymorphisms on trastuzumab efficacy in the adjuvant treatment of ERBB2/HER2-positive breast cancer...
November 3, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27713547/hierarchical-micro-nano-porous-acupuncture-needles-offering-enhanced-therapeutic-properties
#3
Su-Ll In, Young S Gwak, Hye Rim Kim, Abdul Razzaq, Kyeong-Seok Lee, Hee Young Kim, SuChan Chang, Bong Hyo Lee, Craig A Grimes, Chae Ha Yang
Acupuncture as a therapeutic intervention has been widely used for treatment of many pathophysiological disorders. For achieving improved therapeutic effects, relatively thick acupuncture needles have been frequently used in clinical practice with, in turn, enhanced stimulation intensity. However due to the discomforting nature of the larger-diameter acupuncture needles there is considerable interest in developing advanced acupuncture therapeutical techniques that provide more comfort with improved efficacy...
October 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27696125/meniscal-allograft-subluxations-are-not-associated-with-preoperative-native-meniscal-subluxations
#4
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Jae Hyan Kim, Eic Ju Lim
PURPOSE: To determine the relationship between preoperative subluxation of the original menisci and postoperative graft subluxation after lateral meniscal allograft transplantation (MAT). METHODS: Fourteen patients who underwent isolated lateral MATs in meniscus-deficient knees with a low-grade chondral lesion (≤ICRS grade 2) were assessed. Lateral subluxation of the native meniscus before meniscectomy and those of remaining meniscal tissue before MAT were measured on mid-coronal MRI scans taken at each time point...
September 30, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27666984/production-of-methanol-from-methane-by-encapsulated-methylosinus-sporium
#5
Sanjay K S Patel, Jae-Hoon Jeong, Sanjeet Mehariya, Sachin V Otari, Bharat Madan, Jung Rim Haw, Jung-Kul Lee, Liaoyuan Zhang, In-Won Kim
Massive reserves of methane (CH₄) remain unexplored as a feedstock for the production of liquid fuels and chemicals, majorly because of the lack of economically suitable and sustainable strategies for selective oxidation of CH₄ to methanol. The present study demonstrates the bioconversion of CH₄ to methanol mediated by Type I methanotrophs, such as Methylomicrobium album and Methylomicrobium alcaliphilum. Furthermore, immobilization of Type II methanotroph, Methylosinus sporium, was carried out using different encapsulation methods, employing sodium-alginate (Na-alginate) and silica gel...
September 23, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27583902/cerebral-infarct-volume-measurements-to-improve-patient-selection-for-endovascular-treatment
#6
Miran Han, Jin Wook Choi, Nae-Jung Rim, Sun Yong Kim, Hong-Il Suh, Kyu Sun Lee, Ji Man Hong, Jin Soo Lee
Patients who have large cerebral infarctions may not be good candidates for endovascular treatment. Various methods for determining infarct volume have been used in clinical studies. We evaluated the effectiveness of several methods for measuring infarct volume, especially regarding futile outcomes despite endovascular treatment.Patients with acute ischemic stroke in unilateral anterior circulation territory who were treated with intra-arterial thrombectomy were included. For assessing infarct volume, the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) scoring system was applied to images obtained by noncontrast computed tomography (NCCT), postcontrast CT (PCCT), and diffusion-weighted imaging (DWI)...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27433398/a-case-of-long-term-complete-remission-of-advanced-gastric-adenocarcinoma-with-liver-metastasis
#7
Ch'angbum Rim, Jung-Ae Lee, Soojung Gong, Dong Wook Kang, Heebum Yang, Hyun Young Han, Nae Yu Kim
We report the case of a patient with gastric adenocarcinoma with multiple liver metastases. This patient showed complete remission for more than 68 months after S-1/cisplatin combination chemotherapy and radical total gastrectomy. The patient, a 63-year-old man, presented with dyspepsia and difficulty in swallowing. Endoscopic findings showed a huge ulcero-infiltrative mass at the lesser curvature of the mid-body, extending to the distal esophagus. Biopsy revealed a poorly differentiated tubular adenocarcinoma...
June 2016: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/27363491/standardized-evaluation-of-tumor-infiltrating-lymphocytes-in-breast-cancer-results-of-the-ring-studies-of-the-international-immuno-oncology-biomarker-working-group
#8
Carsten Denkert, Stephan Wienert, Audrey Poterie, Sibylle Loibl, Jan Budczies, Sunil Badve, Zsuzsanna Bago-Horvath, Anita Bane, Shahinaz Bedri, Jane Brock, Ewa Chmielik, Matthias Christgen, Cecile Colpaert, Sandra Demaria, Gert Van den Eynden, Giuseppe Floris, Stephen B Fox, Dongxia Gao, Barbara Ingold Heppner, S Rim Kim, Zuzana Kos, Hans H Kreipe, Sunil R Lakhani, Frederique Penault-Llorca, Giancarlo Pruneri, Nina Radosevic-Robin, David L Rimm, Stuart J Schnitt, Bruno V Sinn, Peter Sinn, Nicolas Sirtaine, Sandra A O'Toole, Giuseppe Viale, Koen Van de Vijver, Roland de Wind, Gunter von Minckwitz, Frederick Klauschen, Michael Untch, Peter A Fasching, Toralf Reimer, Karen Willard-Gallo, Stefan Michiels, Sherene Loi, Roberto Salgado
Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic in breast cancer with potential relevance for response to immune-checkpoint inhibitor therapy. Although many groups are currently evaluating TIL, there is no standardized system for diagnostic applications. This study reports the results of two ring studies investigating TIL conducted by the International Working Group on Immuno-oncology Biomarkers. The study aim was to determine the intraclass correlation coefficient (ICC) for evaluation of TIL by different pathologists...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27334261/electromechanical-cardioplasty-using-a-wrapped-elasto-conductive-epicardial-mesh
#9
Jinkyung Park, Suji Choi, Ajit H Janardhan, Se-Yeon Lee, Samarth Raut, Joao Soares, Kwangsoo Shin, Shixuan Yang, Chungkeun Lee, Ki-Woon Kang, Hye Rim Cho, Seok Joo Kim, Pilseon Seo, Wonji Hyun, Sungmook Jung, Hye-Jeong Lee, Nohyun Lee, Seung Hong Choi, Michael Sacks, Nanshu Lu, Mark E Josephson, Taeghwan Hyeon, Dae-Hyeong Kim, Hye Jin Hwang
Heart failure remains a major public health concern with a 5-year mortality rate higher than that of most cancers. Myocardial disease in heart failure is frequently accompanied by impairment of the specialized electrical conduction system and myocardium. We introduce an epicardial mesh made of electrically conductive and mechanically elastic material, to resemble the innate cardiac tissue and confer cardiac conduction system function, to enable electromechanical cardioplasty. Our epicardium-like substrate mechanically integrated with the heart and acted as a structural element of cardiac chambers...
June 22, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27298370/silicic-volcanism-on-mars-evidenced-by-tridymite-in-high-sio2-sedimentary-rock-at-gale-crater
#10
Richard V Morris, David T Vaniman, David F Blake, Ralf Gellert, Steve J Chipera, Elizabeth B Rampe, Douglas W Ming, Shaunna M Morrison, Robert T Downs, Allan H Treiman, Albert S Yen, John P Grotzinger, Cherie N Achilles, Thomas F Bristow, Joy A Crisp, David J Des Marais, Jack D Farmer, Kim V Fendrich, Jens Frydenvang, Trevor G Graff, John-Michael Morookian, Edward M Stolper, Susanne P Schwenzer
Tridymite, a low-pressure, high-temperature (>870 °C) SiO2 polymorph, was detected in a drill sample of laminated mudstone (Buckskin) at Marias Pass in Gale crater, Mars, by the Chemistry and Mineralogy X-ray diffraction instrument onboard the Mars Science Laboratory rover Curiosity The tridymitic mudstone has ∼40 wt.% crystalline and ∼60 wt.% X-ray amorphous material and a bulk composition with ∼74 wt.% SiO2 (Alpha Particle X-Ray Spectrometer analysis). Plagioclase (∼17 wt.% of bulk sample), tridymite (∼14 wt...
June 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27290471/underweight-is-associated-with-mortality-in-patients-with-severe-sepsis-and-septic-shock
#11
S M Lee, J W Kang, Y H Jo, K Kim, J H Lee, J Lee, K P Rim
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27270348/clinical-outcome-from-oxaliplatin-treatment-in-stage-ii-iii-colon-cancer-according-to-intrinsic-subtypes-secondary-analysis-of-nsabp-c-07-nrg-oncology-randomized-clinical-trial
#12
Nan Song, Katherine L Pogue-Geile, Patrick G Gavin, Greg Yothers, S Rim Kim, Nicole L Johnson, Corey Lipchik, Carmen J Allegra, Nicholas J Petrelli, Michael J O'Connell, Norman Wolmark, Soonmyung Paik
IMPORTANCE: Oxaliplatin added to fluorouracil plus leucovorin therapy for patients with colon cancer has been shown to provide significant but modest absolute benefit for disease-free survival. However, acute and chronic neurotoxic effects from this regimen underscore the need for markers that predict oxaliplatin benefit. OBJECTIVE: To test our hypothesis that molecular subtypes of colon cancer would be associated with differential prognosis and benefit from oxaliplatin added to fluorouracil plus leucovorin therapy...
September 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27264863/non-destructive-evaluation-of-bacteria-infected-watermelon-seeds-using-vis-nir-hyperspectral-imaging
#13
Hoonsoo Lee, Moon S Kim, Yu-Rim Song, Changsik Oh, Hyoun-Sub Lim, Wang-Hee Lee, Jum-Soon Kang, Byoung-Kwan Cho
BACKGROUND: It is needed to minimize the economic damage by sorting infected seeds from healthy seeds before seeding. However, current methods of detecting infection seeds such as seedling grow-out, enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and real-time polymerase chain reaction (RT-PCR) have a critical drawback that are time-consuming, labor-intensive, and destructive procedures. The objective of this study was to evaluate the potential of Vis/NIR hyperspectral imaging system for detecting bacteria-infected watermelon seeds...
June 6, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27134806/mineralogy-provenance-and-diagenesis-of-a-potassic-basaltic-sandstone-on-mars-chemin-x-ray-diffraction-of-the-windjana-sample-kimberley-area-gale-crater
#14
Allan H Treiman, David L Bish, David T Vaniman, Steve J Chipera, David F Blake, Doug W Ming, Richard V Morris, Thomas F Bristow, Shaunna M Morrison, Michael B Baker, Elizabeth B Rampe, Robert T Downs, Justin Filiberto, Allen F Glazner, Ralf Gellert, Lucy M Thompson, Mariek E Schmidt, Laetitia Le Deit, Roger C Wiens, Amy C McAdam, Cherie N Achilles, Kenneth S Edgett, Jack D Farmer, Kim V Fendrich, John P Grotzinger, Sanjeev Gupta, John Michael Morookian, Megan E Newcombe, Melissa S Rice, John G Spray, Edward M Stolper, Dawn Y Sumner, Ashwin R Vasavada, Albert S Yen
The Windjana drill sample, a sandstone of the Dillinger member (Kimberley formation, Gale Crater, Mars), was analyzed by CheMin X-ray diffraction (XRD) in the MSL Curiosity rover. From Rietveld refinements of its XRD pattern, Windjana contains the following: sanidine (21% weight, ~Or95); augite (20%); magnetite (12%); pigeonite; olivine; plagioclase; amorphous and smectitic material (~25%); and percent levels of others including ilmenite, fluorapatite, and bassanite. From mass balance on the Alpha Proton X-ray Spectrometer (APXS) chemical analysis, the amorphous material is Fe rich with nearly no other cations-like ferrihydrite...
January 2016: Journal of Geophysical Research. Planets
https://www.readbyqxmd.com/read/27114542/tracking-solvent-and-protein-movement-during-co2-release-in-carbonic-anhydrase-ii-crystals
#15
Chae Un Kim, HyoJin Song, Balendu Sankara Avvaru, Sol M Gruner, SangYoun Park, Robert McKenna
Carbonic anhydrases are mostly zinc metalloenzymes that catalyze the reversible hydration/dehydration of CO2/HCO3 (-) Previously, the X-ray crystal structures of CO2-bound holo (zinc-bound) and apo (zinc-free) human carbonic anhydrase IIs (hCA IIs) were captured at high resolution. Here, we present sequential timeframe structures of holo- [T = 0 s (CO2-bound), 50 s, 3 min, 10 min, 25 min, and 1 h] and apo-hCA IIs [T = 0 s, 50 s, 3 min, and 10 min] during the "slow" release of CO2 Two active site waters, WDW (deep water) and WDW' (this study), replace the vacated space created on CO2 release, and another water, WI (intermediate water), is seen to translocate to the proton wire position W1...
May 10, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27102316/prediction-of-carotid-intraplaque-hemorrhage-using-adventitial-calcification-and-plaque-thickness-on-cta
#16
L B Eisenmenger, B W Aldred, S-E Kim, G J Stoddard, A de Havenon, G S Treiman, D L Parker, J S McNally
BACKGROUND AND PURPOSE: Carotid intraplaque hemorrhage is associated with stroke, plaque thickness, stenosis, ulceration, and adventitial inflammation. Conflicting data exist on whether calcification is a marker of plaque instability, and no data exist on adventitial calcification. Our goal was to determine whether adventitial calcification and soft plaque (a rim sign) help predict carotid intraplaque hemorrhage. MATERIALS AND METHODS: This was a retrospective cohort study of 96 patients who underwent carotid MRA and CTA within 1 month, from 2009 to 2016...
August 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27032891/synthesis-and-evaluation-of-6-3-18-f-fluoro-2-hydroxypropyl-substituted-2-pyridylbenzothiophenes-and-2-pyridylbenzothiazoles-as-potential-pet-tracers-for-imaging-a%C3%AE-plaques
#17
Byoung Se Lee, So Young Chu, Hye Rim Kwon, Chansoo Park, Uthaiwan Sirion, Damian Brockschnieder, Thomas Dyrks, Seung Jun Oh, Jae Seung Kim, Dae Yoon Chi
3-[(18)F]Fluoro-2-hydroxypropyl substituted compounds were synthesized and evaluated as novel (18)F-labeled PET tracers for imaging Aβ plaque in a living brain. All compounds exhibited high binding affinities toward the synthetic Aβ1-42 aggregate and/or Alzheimer's disease brain homogenate. In the microPET study with normal mice, the 3-[(18)F]fluoro-2-hydroxypropyl substituted compounds resulted in fast brain washout by reducing the lipophilicities of the compounds. Intriguingly, (S)-configured PET tracers, (S)-[(18)F]1b and (S)-[(18)F]1c, exhibited a 2...
May 1, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27027298/quantitative-probing-of-cu-2-ions-naturally-present-in-single-living-cells
#18
Junho Lee, Hwa-Rim Lee, Jaeyeon Pyo, Youngseob Jung, Ji-Young Seo, Hye Guk Ryu, Kyong-Tai Kim, Jung Ho Je
Quantitative probing of Cu(2+) ions naturally present in single living cells is realized by developing a quantum-dot-embedded nanowire-waveguide probe. The intracellular Cu(2+) ion concentration is quantified by direct monitoring of photoluminescence quenching during the insertion of the nanowire in a living neuron. The measured intracellular Cu(2+) ion concentration is 3.34 ± 1.04 × 10(-6) m (mean ± s.e.m.) in single hippocampal neurons.
June 2016: Advanced Materials
https://www.readbyqxmd.com/read/26999084/fumigant-toxicity-of-lamiaceae-plant-essential-oils-and-blends-of-their-constituents-against-adult-rice-weevil-sitophilus-oryzae
#19
Sung-Woong Kim, Hyo-Rim Lee, Myeong-Jin Jang, Chan-Sik Jung, Il-Kwon Park
To find a new and safe alternative to conventional insecticides, we evaluated the fumigant toxicity of eight Lamiaceae essential oils and their constituents against the adult rice weevil Sitophilus oryzae. Of the eight species tested, hyssop (Hyssopus offcinalis), majoram (Origanum majorana), and Thymus zygis essential oils showed strong fumigant toxicity against S. oryzae adults at 25 mg/L air concentration. Constituents of active essential oils were analyzed by gas chromatography coupled to flame ionization detector (FID) and gas chromatography-mass spectrometry...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26996294/poly-l-lactic-acid-gelatin-fibrous-scaffold-loaded-with-simvastatin-beta-cyclodextrin-modified-hydroxyapatite-inclusion-complex-for-bone-tissue-regeneration
#20
Jung Bok Lee, Ji Eun Kim, Daniel A Balikov, Min Soo Bae, Dong Nyoung Heo, Donghyun Lee, Hyun Joon Rim, Deok-Won Lee, Hak-Joon Sung, Il Keun Kwon
Recently, the application of nanostructured materials in the field of tissue engineering has garnered attention to mediate treatment and regeneration of bone defects. In this study, poly(l-lactic acid) (PLLA)/gelatin (PG) fibrous scaffolds are fabricated and β-cyclodextrin (βCD) grafted nano-hydroxyapatite (HAp) is coated onto the fibrous scaffold surface via an interaction between βCD and adamantane. Simvastatin (SIM), which is known to promote osteoblast viability and differentiation, is loaded into the remaining βCD...
July 2016: Macromolecular Bioscience
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