Keeley O'Grady, Stacey Hong, Papanin Putsathit, Narelle George, Christine Hemphill, Peter G Huntington, Tony M Korman, Despina Kotsanas, Monica Lahra, Rodney McDougall, Andrew McGlinchey, Avram Levy, Casey V Moore, Graeme Nimmo, Louise Prendergast, Jennifer Robson, David J Speers, Lynette Waring, Michael C Wehrhahn, Gerhard F Weldhagen, Richard M Wilson, Thomas V Riley, Daniel R Knight
Clostridioides difficile infection (CDI) remains a significant public health threat globally. New interventions to treat CDI rely on an understanding of the evolution and epidemiology of circulating strains. Here we provide longitudinal genomic data on strain diversity, transmission dynamics and antimicrobial resistance (AMR) of C. difficile ribotypes (RTs) 014/020 ( n =169), 002 ( n =77) and 056 ( n =36), the three most prominent C. difficile strains causing CDI in Australia. Genome scrutiny showed that AMR was uncommon in these lineages, with resistance-conferring alleles present in only 15/169 RT014/020 strains (8...
May 2024: Microbial Genomics