Kohei Chida, Hirofumi Kanazawa, Hirotaka Kinoshita, Arya Mariam Roy, Kenichi Hakamada, Kazuaki Takabe
Since its development in 1943, lidocaine has been one of the most commonly used local anesthesia agents for surgical procedures. Lidocaine alters neuronal signal transmission by prolonging the inactivation of fast voltage-gated sodium channels in the cell membrane of neurons, which are responsible for action potential propagation. Recently, it has attracted attention due to emerging evidence suggesting its potential antitumor properties, particularly in the in vitro setting. Further, local administration of lidocaine around the tumor immediately prior to surgical removal has been shown to improve overall survival in breast cancer patients...
May 1, 2024: Pharmacology & Therapeutics