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https://www.readbyqxmd.com/read/28935774/immunotherapy-a-new-and-old-approach-to-treatment-of-soft-tissue-and-bone-sarcomas
#1
REVIEW
Michael J Nathenson, Anthony P Conley, Edward Sausville
Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28934554/improvements-in-clinical-practice-for-fertility-preservation-among-young-cancer-patients-results-from-bundled-interventions
#2
Natalie K Bradford, Roderick Walker, Roslyn Henney, Po Inglis, Raymond J Chan
AIMS: The consequences of cancer and treatment on fertility can be a continuing source of distress for adolescents and young adults. The study aims were to assess the effects of bundled interventions on clinical practice concerning fertility in young people aged 14-25 years with cancer. METHODS: Bundled interventions, including development of quality indicators, resources, and targeted education, were introduced during 2015 across five cancer centers. Data before interventions (2012-2014) were compared with data prospectively collected during 2015-2016...
September 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28933526/impact-of-radioguided-occult-lesion-localization-roll-in-the-management-of-cervical-recurrences-from-differentiated-thyroid-cancer
#3
Viviana Garbaccio, Massimo Menga, Giovanni Mensa, Roberto Passera, Antonello Galati, Alessandra Codegone, Monica Finessi, Emanuela Pilati, Désirée Deandreis, Riccardo E Pellerito
BACKGROUND: Surgery is the elective treatment for cervical relapse from differentiated thyroid cancer (DTC) but it is technically challenging, with risk of failure and morbidity. We explored the feasibility and the efficacy of Radioguided Occult Lesion Localization (ROLL) with intratumoral 99mTc radiolabeled human albumin macroaggregates ([99mTc]MAA) injection in this setting. METHODS: Fifteen patients who underwent ROLL by ultrasonography (US)-guided intratumoral injection of [99mTc]MAA between December 2013 and October 2016 for DTC recurrence were considered for this study...
September 20, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28932769/microrna-expression-in-a-phosphaturic-mesenchymal-tumour
#4
Darrell Green, Irina Mohorianu, Isabelle Piec, Jeremy Turner, Clare Beadsmoore, Andoni Toms, Richard Ball, John Nolan, Iain McNamara, Tamas Dalmay, William D Fraser
Phosphaturic mesenchymal tumours are a heterogeneous set of bone and soft tissue neoplasms that can cause a number of paraneoplastic syndromes such as tumour induced osteomalacia. The term phosphaturic comes from the common finding that these tumours secrete high levels of fibroblast growth factor 23 which causes renal phosphate wasting leading to hypophosphatemia. Phosphaturic mesenchymal tumours are rare and diagnosis is difficult. A very active 68 year old male presented with bone pain and muscle weakness...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28932548/predictors-of-conversion-to-thoracotomy-during-video-assisted-thoracoscopic-surgery-lobectomy-in-lung-cancer-additional-predictive-value-of-fdg-pet-ct-in-a-tuberculosis-endemic-region
#5
Chun Geun Lim, Kyung Min Shin, Ji Seun Lim, Jae Kwang Lim, Hye Jung Kim, Won Hwa Kim, Seung Hyun Cho, Seung Ick Cha, Eung Bae Lee, Yangki Seock, Shin Young Jeong
BACKGROUND: To evaluate the added clinical value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scans to chest CT imaging in predicting the conversion to thoracotomy during video-assisted thoracoscopic surgery (VATS) lobectomy in patients with lung cancer. METHODS: This is a retrospective study of 235 consecutive patients who underwent planned VATS lobectomy for primary lung cancer between 2011 and 2015. CT images were interpreted in terms of the presence and the attenuation of peribronchial lymph nodes (PLN) and peribronchial cuffs of soft (PCS) tissue, pleural calcification, and parenchymal calcified nodule...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28927090/downregulation-of-pdcd4-by-mir-21-suppresses-tumor-transformation-and-proliferation-in-a-nude-mouse-renal-cancer-model
#6
Haixin Yuan, Shiyong Xin, Yaoping Huang, Yingfan Bao, Hao Jiang, Liqing Zhou, Xiaoqiang Ren, Liang Li, Qian Wang, Jianguo Zhang
Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 in a nude mouse renal cancer model. A total of 24 BALB/c male nude mice were randomly assigned into the following three groups: Negative control (NC; n=8), miR-21 inhibitor (n=8) and miR-21 mimic (n=8)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926423/a-noninterventional-multicenter-prospective-phase-iv-study-of-trabectedin-in-patients-with-advanced-soft-tissue-sarcoma
#7
Angela Buonadonna, Charlotte Benson, Jose Casanova, Bernd Kasper, Antonio López Pousa, Filomena Mazzeo, Thomas Brodowicz, Nicolas Penel
This prospective, noninterventional study is the first phase IV trial designed to evaluate trabectedin in patients with advanced soft tissue sarcoma in real-life clinical practice across Europe. To be included in the study, patients must have received more than or equal to one cycle of trabectedin and be currently on treatment. The primary endpoint was progression-free survival as defined by investigators. The secondary endpoints included objective response rate, disease control rate, time to progression and the growth modulation index (GMI), overall survival, and an assessment of the cancer-related symptoms and safety...
September 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28923841/a-novel-notch-yap-circuit-drives-stemness-and-tumorigenesis-in-embryonal-rhabdomyosarcoma
#8
Katherine K Slemmons, Lisa E S Crose, Stefan Riedel, Manuela Sushnitha, Brian C Belyea, Corinne M Linardic
Rhabdomyosarcoma (RMS), a cancer characterized by skeletal muscle features, is the most common soft tissue sarcoma of childhood. While low and intermediate-risk groups have seen improved outcomes, high-risk patients still face a 5-year survival of <30%, a statistic that has not changed in over 40 years. Understanding the biologic underpinnings of RMS is critical. The developmental pathways of Notch and YAP have been identified as potent but independent oncogenic signals that support the embryonal variant of RMS (eRMS)...
September 18, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28922190/spinal-metastasis-characterized-on-fdg-pet-ct-in-head-and-neck-squamous-cell-carcinoma
#9
Shahroz Khan, Hannah Son
Spinal metastases are rare in head and neck cancer. We present a rare case of vocal cord squamous cell cancer that metastasized to the spinal cord and cauda equina. A 63-year-old man presented with acute back pain and bilateral leg weakness 5 months after having a surgical treatment for moderately differentiated vocal cord squamous cell cancer (T2 N0 M0). Restaging F-FDG PET examination demonstrated a soft tissue mass with intense hypermetabolism in the distal spinal cord and a hypermetabolic leptomeningeal metastatic deposit at the L3 level...
September 15, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28921170/comparison-of-novel-multi-level-otsu-mo-pet-and-conventional-pet-segmentation-methods-for-measuring-fdg-metabolic-tumor-volume-in-patients-with-soft-tissue-sarcoma
#10
Inki Lee, Hyung-Jun Im, Meiyappan Solaiyappan, Steve Y Cho
BACKGROUND: We have previously developed a novel and highly consistent PET segmentation algorithm using a multi-level Otsu method (MO-PET). The aim of this study was to evaluate the reliability of MO-PET compared to conventional PET segmentation methods for measuring (18)F-FDG (FDG) PET metabolic tumor volume (MTV) in patients with soft tissue sarcoma (STS). Clinical and imaging data were obtained from the Cancer Imaging Archive. Forty-eight STS patients with FDG PET/CT and MR prior to therapy were analyzed...
September 18, 2017: EJNMMI Physics
https://www.readbyqxmd.com/read/28919092/cervical-soft-tissue-recurrence-of-differentiated-thyroid-carcinoma-after-thyroidectomy-indicates-a-poor-prognosis
#11
Luying Gao, Yuxin Jiang, Zhiyong Liang, Lei Zhang, Xinxin Mao, Xiao Yang, Ying Wang, Jingzhu Xu, Ruyu Liu, Shenling Zhu, Ruina Zhao, Xingjian Lai, Xiaoyan Zhang, Bo Zhang
BACKGROUND: We investigated cervical soft tissue recurrence of differentiated thyroid carcinoma (DTC) after thyroidectomy, and these lesions exhibited no evidence that they were lymph nodes (LNs). METHODS: Between January 2012 and April 2016, consecutive 6308 patients underwent thyroid surgery for DTC at our center. Among them, we encountered 21 patients with recurrent cervical soft tissue lesions, none of whom had previously undergone fine needle aspiration biopsy (FNAB)...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28918264/past-matrix-stiffness-primes-epithelial-cells-and-regulates-their-future-collective-migration-through-a-mechanical-memory
#12
Samila Nasrollahi, Christopher Walter, Andrew J Loza, Gregory V Schimizzi, Gregory D Longmore, Amit Pathak
During morphogenesis and cancer metastasis, grouped cells migrate through tissues of dissimilar stiffness. Although the influence of matrix stiffness on cellular mechanosensitivity and motility are well-recognized, it remains unknown whether these matrix-dependent cellular features persist after cells move to a new microenvironment. Here, we interrogate whether priming of epithelial cells by a given matrix stiffness influences their future collective migration on a different matrix - a property we refer to as the 'mechanical memory' of migratory cells...
September 8, 2017: Biomaterials
https://www.readbyqxmd.com/read/28917265/olaratumab-pdgfr-%C3%AE-inhibition-as-a-novel-tool-in-the-treatment-of-advanced-soft-tissue-sarcomas
#13
REVIEW
Bruno Vincenzi, Giuseppe Badalamenti, Andrea Napolitano, Mariella Spalato Ceruso, Francesco Pantano, Giovanni Grignani, Antonio Russo, Daniele Santini, Massimo Aglietta, Giuseppe Tonini
Advanced soft tissue sarcomas are aggressive cancers with limited therapeutic options. Recently, inhibition of platelet-derived growth factor receptor (PDGFR)-α by the monoclonal antibody olaratumab showed promising clinical activity. If confirmed, this would be one of the first examples of targeted therapy effective in advanced soft tissue sarcomas therapy independently of the histologic subtype. Here, we reviewed the biology of the PDGF/PDGFR axis, particularly focusing on its role in cancer, and then we discussed on the effects of PDGFR-α inhibition in the therapy of advanced soft tissue sarcomas...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#14
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions s worldwide, to date, MicroRNA 1290 (miRNA) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells, its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay and soft agar growth assay. IN addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced p27 level and increased Cyclin D1 level both in mRNA and protein levels, while miR-1290 knockdown increased p27 and reduced Cyclin D1 (confirming miR-1290 promoted CRC cell proliferation)...
September 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#15
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28914440/olaratumab-in-combination-with-doxorubicin-for-the-treatment-of-advanced-soft-tissue-sarcoma-an-evidence-review-group-perspective-of-a-national-institute-for-health-and-care-excellence-single-technology-appraisal
#16
REVIEW
Irina A Tikhonova, Tracey Jones-Hughes, James Dunham, Fiona C Warren, Sophie Robinson, Peter Stephens, Martin Hoyle
The manufacturer of olaratumab (Lartruvo(®)), Eli Lilly & Company Limited, submitted evidence for the clinical and cost effectiveness of this drug, in combination with doxorubicin, for untreated advanced soft tissue sarcoma (STS) not amenable to surgery or radiotherapy, as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal process. The Peninsula Technology Assessment Group, commissioned to act as the Evidence Review Group (ERG), critically reviewed the company's submission...
September 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28910916/-primary-tracheal-malignant-glomus-tumor-with-lung-metastasis-diagnosed-by-pathological-analysis-a-case-report-and-literature-review
#17
B Huang, F G Chen, J Zhuang, W C Zheng, W Y Zhu, Q C Zhang, S H Wang, C M Guo, C M Xie
Objective: To study the clinical manifestations, pathological features, diagnosis, differential diagnosis, treatment and prognosis of primary tracheobronchial or pulmonary malignant glomus tumor (MGT). Methods: A case of primary tracheal MGT with lung metastasis diagnosed by pathological analysis admitted to Affiliated Shantou Hospital of Sun Yat-sen University in May. 2015 was analyzed, and the related literatures were reviewed. We searched databases including PubMed, Embase, Ovid, Cochrane, Wanfang and Chinese National Knowledge infrastructure (CNKI), using the keyword "tracheal or bronchial or pulmonary malignant glomus tumor" from Jan...
September 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28902468/fine-needle-aspiration-of-lipoblastoma-cytological-molecular-and-clinical-features
#18
Joana Ferreira, Gonçalo Esteves, Ricardo Fonseca, Carmo Martins, Saudade André, Maria Manuel Lemos
BACKGROUND: Lipoblastomas are rare, benign adipocytic tumors that present mostly during infancy. In about 70% of cases, these tumors carry abnormalities in chromosome 8, mainly leading to rearrangements of the PLAG1 gene. METHODS: We report a series of histologically proven lipoblastomas with previous fine-needle aspiration (FNA) cytology from 9 patients (n = 10 samples) and describe their clinical, cytological, and molecular features. RESULTS: Our cohort included 5 boys and 4 girls (median age, 2...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28898423/iterative-volume-of-interest-based-4d-cone-beam-ct
#19
Rachael Martin, Moiz Ahmad, Geoffrey Hugo, Tinsu Pan
PURPOSE: 4D cone-beam CT (CBCT) has potential applications in soft tissue alignment and tumor motion verification at the time of radiation treatment. However, prominent streak artifacts with conventional image reconstructions have limited its clinical use and alternative reconstructions are generally too computationally expensive for the time available. We propose an iterative volume of interest based (I4D VOI) reconstruction technique, where 4D reconstruction is only performed within a VOI, to limit streak artifacts with limited added computation time...
September 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28895916/micrornas-in-different-histologies-of-soft-tissue-sarcoma-a-comprehensive-review
#20
REVIEW
Maria Anna Smolle, Andreas Leithner, Florian Posch, Joanna Szkandera, Bernadette Liegl-Atzwanger, Martin Pichler
Soft tissue sarcomas (STS) constitute a rare tumour entity comprising over 50 histological subtypes. MicroRNAs (miRNAs) are short non-protein coding RNA molecules that regulate gene expression by targeting the 3'-untranslated region of messenger RNAs. They are involved in a variety of human diseases, including malignancies, such as endometrial cancer, osteosarcoma, bronchial carcinoma and breast cancer. In STS, various miRNAs are differentially expressed, thus contributing to development, progression and invasion...
September 12, 2017: International Journal of Molecular Sciences
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