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https://www.readbyqxmd.com/read/28524857/a-defined-metabolic-state-in-pre-b-cells-governs-b-cell-development-and-is-counterbalanced-by-swiprosin-2-efhd1
#1
Merle Stein, Sebastian Dütting, Dimitrios Mougiakakos, Michael Bösl, Kristin Fritsch, Dorothea Reimer, Sophia Urbanczyk, Tobit Steinmetz, Wolfgang Schuh, Aline Bozec, Thomas H Winkler, Hans-Martin Jäck, Dirk Mielenz
B-cell development in the bone marrow comprises proliferative and resting phases in different niches. We asked whether B-cell metabolism relates to these changes. Compared to pro B and small pre B cells, large pre B cells revealed the highest glucose uptake and ROS but not mitochondrial mass, whereas small pre B cells exhibited the lowest mitochondrial membrane potential. Small pre B cells from Rag1(-/-);33.C9 μ heavy chain knock-in mice revealed decreased glycolysis (ECAR) and mitochondrial spare capacity compared to pro B cells from Rag1(-/-) mice...
May 19, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28523471/quantification-of-left-atrial-volume-and-phasic-function-using-cardiovascular-magnetic-resonance-imaging-comparison-of-biplane-area-length-method-and-simpson-s-method
#2
Laura Kristin Wandelt, Johannes Tammo Kowallick, Andreas Schuster, Rolf Wachter, Thomas Stümpfig, Christina Unterberg-Buchwald, Michael Steinmetz, Christian Oliver Ritter, Joachim Lotz, Wieland Staab
Left atrial (LA) enlargement and dysfunction are markers of chronic diastolic dysfunction and an important predictor of adverse cardiovascular and cerebrovascular outcomes. Accordingly, accurate quantification of left atrial volume (LAV) and function is needed. In routine clinical cardiovascular magnetic resonance (CMR) imaging the biplane area-length method (Bi-ALM) is frequently applied due to time-saving image acquisition and analysis. However, given the varying anatomy of the LA we hypothesized that the diagnostic accuracy of the Bi-ALM is not sufficient and that results would be different from a precise volumetric assessment of transversal multi-slice cine images using Simpson's method...
May 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28507031/memory-consolidation-within-the-central-amygdala-is-not-necessary-for-modulation-of-cerebellar-learning
#3
Adam B Steinmetz, Ka H Ng, John H Freeman
Amygdala lesions impair, but do not prevent, acquisition of cerebellum-dependent eyeblink conditioning suggesting that the amygdala modulates cerebellar learning. Two-factor theories of eyeblink conditioning posit that a fast-developing memory within the amygdala facilitates slower-developing memory within the cerebellum. The current study tested this hypothesis by impairing memory consolidation within the amygdala with inhibition of protein synthesis, transcription, and NMDA receptors in rats. Rats given infusions of anisomycin or DRB into the central amygdala (CeA) immediately after each eyeblink conditioning session were severely impaired in contextual and cued fear conditioning, but were completely unimpaired in eyeblink conditioning...
June 2017: Learning & Memory
https://www.readbyqxmd.com/read/28506003/synergy-effects-of-combined-multichannel-emg-triggered-electrical-stimulation-and-mirror-therapy-in-subacute-stroke-patients-with-severe-or-very-severe-arm-hand-paresis
#4
Thomas Schick, Hans-Peter Schlake, Juliane Kallusky, Günter Hohlfeld, Maria Steinmetz, Florian Tripp, Karsten Krakow, Michaela Pinter, Christian Dohle
BACKGROUND: Neurorehabilitation requires the development of severity-dependent and successful therapies for arm/hand rehabilitation in stroke patients. OBJECTIVE: To evaluate the effectiveness of adding mirror therapy to bilateral EMG-triggered multi-channel electrostimulation for the treatment of severe arm/hand paresis in stroke patients. METHODS: The subjects of this randomized, controlled, multicentre study were stroke patients who had suffered their first insult between 1 and 6 months before study start and had severe or very severe arm/hand paresis, as classified by Fugl-Meyer-Assessment...
May 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28495537/impact-of-nutritional-state-on-critical-limb-ischemia-early-outcomes-denucriticc-study
#5
Lucie Salomon du Mont, Betty Leclerc, Marie-Catherine Morgant, Guillaume Besch, Aline Laubriet, Eric Steinmetz, Simon Rinckenbach
INTRODUCTION: Despite current progress, the prognosis of critical limb ischemia (CLI) remains poor. The ageing of the population, the increasing prevalence of diabetes mellitus, and the stability of tabacco use will increase the prevalence of CLI. CLI patients have risk factors for malnutrition and the impact of malnutrition on morbidity and mortality has been demonstrated in the general population. However, we have little information on the consequences of the consequences of undernutrition in the CLI population...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28495242/the-association-between-the-hospital-consumer-assessment-of-healthcare-providers-and-systems-hcahps-survey-and-real-world-clinical-outcomes-in-lumbar-spine-surgery
#6
Jay M Levin, Robert D Winkelman, Gabriel A Smith, Joseph Tanenbaum, Edward C Benzel, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: The patient experience of care as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is currently used to determine hospital reimbursement. The current literature inconsistently demonstrates an association between patient satisfaction and surgical outcomes. PURPOSE: To determine whether patient satisfaction with hospital experience is associated with better clinical outcomes in lumbar spine surgery...
May 8, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28473974/heart-transplantation-in-a-toddler-with-cardiac-kawasaki-disease
#7
Theodor Tirilomis, Michael Steinmetz, Marius Grossmann, Anselm Bräuer, Thomas Paul, Wolfgang Ruschewski, Friedrich A Schöndube
Kawasaki disease is very rare in Western Europe. The disease may involve coronary arteries. A 2-year-old boy diagnosed with Kawasaki disease had had seizure-like symptoms. Further evaluation revealed recurrent myocardial ischemia and myocardial infarction. Due to extraordinary extension of the coronary disease, myocardial revascularization was not feasible and the toddler underwent successful heart transplantation after 97 days on waiting list.
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28467495/identification-of-shedders-of-elephant-endotheliotropic-herpesviruses-among-asian-elephants-elephas-maximus-in-switzerland
#8
Mathias Ackermann, Jean-Michel Hatt, Nelli Schetle, Hanspeter Steinmetz
Elephants, particularly Asian (Elephas maximus), are threatened by lethal elephant hemorrhagic disease (EHD) due to elephant endotheliotropic herpesviruses (EEHV). At least five of seven known EEHV types have been associated to EHD, with types 1, 4, and 5 predominantly affecting Asian elephants. In Switzerland, at least three Asian elephants have been lost due to EHD but nothing is known about the present EEHV1 circulation. Moreover, the prevalence of other EEHV types has never been assessed. Intermittent shedding of EEHV can be monitored through collecting trunk secretions and analyzing them by PCR methods that discriminate the different EEHV types...
2017: PloS One
https://www.readbyqxmd.com/read/28464560/matriptase-induces-metalloproteinase-dependent-aggrecanolysis-in-vitro-and-in-vivo-multiple-mechanisms-promote-cartilage-damage-in-osteoarthritis
#9
David J Wilkinson, Angela Habgood, Heather K Lamb, Paul Thompson, Alastair R Hawkins, Antoine Désilets, Richard Leduc, Torsten Steinmetzer, Maya Hammami, Melody S Lee, Charles S Craik, Sharon Watson, Hua Lin, Jennifer M Milner, Andrew D Rowan
Objectives To assess the ability of the type II transmembrane serine proteinase matriptase to promote aggrecan loss from cartilage of osteoarthritis (OA) patients, and whether matriptase inhibition could prevent aggrecan loss and cartilage damage in experimental OA. Methods Aggrecan release was assessed from human OA cartilage explants and human stem cell-derived cartilage discs, whilst cartilage conditioned media were used for western blotting. Gene expression was analysed by real-time PCR. Murine OA was induced by surgical destabilisation of the medial meniscus, and matriptase inhibitors delivered via osmotic mini-pump or intra-articular injection...
May 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28461957/pigmented-villonodular-synovitis-of-the-hip
#10
Sylvain Steinmetz, Anne-Laure Rougemont, Robin Peter
Pigmented villonodular synovitis (PVNS) is a rare disease that can affect any joint, bursa or tendon sheath.The hip is less frequently affected than the knee, and hence is less discussed in scientific journals.PVNS of the hip mainly occurs in young adults, requiring early diagnosis and adequate treatment to obtain good results.There is no consensus on the management of PVNS of the hip in current literature.We will discuss the options for surgical intervention in hip PVNS using a literature review of clinical, biological, etiological, histological and radiographic aspects of the disease...
June 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28451494/c5-palsy-after-cervical-spine-surgery-a-multicenter-retrospective-review-of-59-cases
#11
Sara E Thompson, Zachary A Smith, Wellington K Hsu, Ahmad Nassr, Thomas E Mroz, David E Fish, Jeffrey C Wang, Michael G Fehlings, Chadi A Tannoury, Tony Tannoury, P Justin Tortolani, Vincent C Traynelis, Ziya Gokaslan, Alan S Hilibrand, Robert E Isaacs, Praveen V Mummaneni, Dean Chou, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Rick C Sasso, Paul M Arnold, Zorica Buser, Mohamad Bydon, Michelle J Clarke, Anthony F De Giacomo, Adeeb Derakhshan, Bruce Jobse, Elizabeth L Lord, Daniel Lubelski, Eric M Massicotte, Michael P Steinmetz, Gabriel A Smith, Jonathan Pace, Mark Corriveau, Sungho Lee, Peter I Cha, Dhananjay Chatterjee, Erica L Gee, Erik N Mayer, Owen J McBride, Allison K Roe, Marisa Y Yanez, D Alex Stroh, Khoi D Than, K Daniel Riew
STUDY DESIGN: A multicenter, retrospective review of C5 palsy after cervical spine surgery. OBJECTIVE: Postoperative C5 palsy is a known complication of cervical decompressive spinal surgery. The goal of this study was to review the incidence, patient characteristics, and outcome of C5 palsy in patients undergoing cervical spine surgery. METHODS: We conducted a multicenter, retrospective review of 13 946 patients across 21 centers who received cervical spine surgery (levels C2 to C7) between January 1, 2005, and December 31, 2011, inclusive...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451493/a-multicenter-study-of-the-presentation-treatment-and-outcomes-of-cervical-dural-tears
#12
Kevin R O'Neill, Michael G Fehlings, Thomas E Mroz, Zachary A Smith, Wellington K Hsu, Adam S Kanter, Michael P Steinmetz, Paul M Arnold, Praveen V Mummaneni, Dean Chou, Ahmad Nassr, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Justin S Smith, Christopher Shaffrey, Chadi A Tannoury, Tony Tannoury, Ziya L Gokaslan, Jeffrey L Gum, Robert A Hart, Robert E Isaacs, Rick C Sasso, David B Bumpass, Mohamad Bydon, Mark Corriveau, Anthony F De Giacomo, Adeeb Derakhshan, Bruce C Jobse, Daniel Lubelski, Sungho Lee, Eric M Massicotte, Jonathan R Pace, Gabriel A Smith, Khoi D Than, K Daniel Riew
STUDY DESIGN: Retrospective multicenter case series study. OBJECTIVE: Because cervical dural tears are rare, most surgeons have limited experience with this complication. A multicenter study was performed to better understand the presentation, treatment, and outcomes following cervical dural tears. METHODS: Multiple surgeons from 23 institutions retrospectively identified 21 rare complications that occurred between 2005 and 2011, including unintentional cervical dural tears...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451490/incidence-and-outcomes-of-acute-implant-extrusion-following-anterior-cervical-spine-surgery
#13
Gabriel A Smith, Jonathan Pace, Mark Corriveau, Sungho Lee, Thomas E Mroz, Ahmad Nassr, Michael G Fehlings, Robert A Hart, Alan S Hilibrand, Paul M Arnold, David B Bumpass, Ziya Gokaslan, Mohamad Bydon, Jeremy L Fogelson, Eric M Massicotte, K Daniel Riew, Michael P Steinmetz
STUDY DESIGN: Multi-institutional retrospective case series of 8887 patients who underwent anterior cervical spine surgery. OBJECTIVE: Anterior decompression from discectomy or corpectomy is not without risk. Surgical morbidity ranges from 9% to 20% and is likely underreported. Little is known of the incidence and effects of rare complications on functional outcomes following anterior spinal surgery. In this retrospective review, we examined implant extrusions (IEs) following anterior cervical fusion...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451487/epidemiology-and-outcomes-of-vertebral-artery-injury-in-16%C3%A2-582-cervical-spine-surgery-patients-an-aospine-north-america-multicenter-study
#14
Wellington K Hsu, Abhishek Kannan, Harry T Mai, Michael G Fehlings, Zachary A Smith, Vincent C Traynelis, Ziya L Gokaslan, Alan S Hilibrand, Ahmad Nassr, Paul M Arnold, Thomas E Mroz, Mohamad Bydon, Eric M Massicotte, Wilson Z Ray, Michael P Steinmetz, Gabriel A Smith, Jonathan Pace, Mark Corriveau, Sungho Lee, Robert E Isaacs, Jeffrey C Wang, Elizabeth L Lord, Zorica Buser, K Daniel Riew
STUDY DESIGN: A multicenter retrospective case series was compiled involving 21 medical institutions. Inclusion criteria included patients who underwent cervical spine surgery between 2005 and 2011 and who sustained a vertebral artery injury (VAI). OBJECTIVE: To report the frequency, risk factors, outcomes, and management goals of VAI in patients who have undergone cervical spine surgery. METHODS: Patients were evaluated on the basis of condition-specific functional status using the Neck Disability Index (NDI), modified Japanese Orthopaedic Association (mJOA) score, the Nurick scale, and the 36-Item Short-Form Health Survey (SF-36)...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451482/thoracic-duct-injury-following-cervical-spine-surgery-a-multicenter-retrospective-review
#15
Adeeb Derakhshan, Daniel Lubelski, Michael P Steinmetz, Mark Corriveau, Sungho Lee, Jonathan R Pace, Gabriel A Smith, Ziya Gokaslan, Mohamad Bydon, Paul M Arnold, Michael G Fehlings, K Daniel Riew, Thomas E Mroz
STUDY DESIGN: Multicenter retrospective case series. OBJECTIVE: To determine the rate of thoracic duct injury during cervical spine operations. METHODS: A retrospective case series study was conducted among 21 high-volume surgical centers to identify instances of thoracic duct injury during anterior cervical spine surgery. Staff at each center abstracted data for each identified case into case report forms. All case report forms were collected by the AOSpine North America Clinical Research Network Methodological Core for data processing, cleaning, and analysis...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28451481/rare-complications-of-cervical-spine-surgery-pseudomeningocoele
#16
Tamir Ailon, Justin S Smith, Ahmad Nassr, Zachary A Smith, Wellington K Hsu, Michael G Fehlings, David E Fish, Jeffrey C Wang, Alan S Hilibrand, Praveen V Mummaneni, Dean Chou, Rick C Sasso, Vincent C Traynelis, Paul M Arnold, Thomas E Mroz, Zorica Buser, Elizabeth L Lord, Eric M Massicotte, Arjun S Sebastian, Khoi D Than, Michael P Steinmetz, Gabriel A Smith, Jonathan Pace, Mark Corriveau, Sungho Lee, K Daniel Riew, Christopher Shaffrey
STUDY DESIGN: This study was a retrospective, multicenter cohort study. OBJECTIVES: Rare complications of cervical spine surgery are inherently difficult to investigate. Pseudomeningocoele (PMC), an abnormal collection of cerebrospinal fluid that communicates with the subarachnoid space, is one such complication. In order to evaluate and better understand the incidence, presentation, treatment, and outcome of PMC following cervical spine surgery, we conducted a multicenter study to pool our collective experience...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28445465/assembly-of-functionally-integrated-human-forebrain-spheroids
#17
Fikri Birey, Jimena Andersen, Christopher D Makinson, Saiful Islam, Wu Wei, Nina Huber, H Christina Fan, Kimberly R Cordes Metzler, Georgia Panagiotakos, Nicholas Thom, Nancy A O'Rourke, Lars M Steinmetz, Jonathan A Bernstein, Joachim Hallmayer, John R Huguenard, Sergiu P Paşca
The development of the nervous system involves a coordinated succession of events including the migration of GABAergic (γ-aminobutyric-acid-releasing) neurons from ventral to dorsal forebrain and their integration into cortical circuits. However, these interregional interactions have not yet been modelled with human cells. Here we generate three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAergic neurons...
May 4, 2017: Nature
https://www.readbyqxmd.com/read/28436967/microtubule-minus-end-regulation-at-spindle-poles-by-an-aspm-katanin-complex
#18
Kai Jiang, Lenka Rezabkova, Shasha Hua, Qingyang Liu, Guido Capitani, A F Maarten Altelaar, Albert J R Heck, Richard A Kammerer, Michel O Steinmetz, Anna Akhmanova
ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein family that regulates spindle architecture, but the underlying mechanism is poorly understood. Here, we show that ASPM forms a complex with another protein linked to microcephaly, the microtubule-severing ATPase katanin. ASPM and katanin localize to spindle poles in a mutually dependent manner and regulate spindle flux. X-ray crystallography revealed that the heterodimer formed by the N- and C-terminal domains of the katanin subunits p60 and p80, respectively, binds conserved motifs in ASPM...
May 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28426952/plant-viruses-and-bacteriophages-for-drug-delivery-in-medicine-and-biotechnology
#19
REVIEW
Anna E Czapar, Nicole F Steinmetz
There are a wide variety of synthetic and naturally occurring nanomaterials under development for nanoscale cargo-delivery applications. Viruses play a special role in these developments, because they can be regarded as naturally occurring nanomaterials evolved to package and deliver cargos. While any nanomaterial has its advantage and disadvantages, viral nanoparticles (VNPs), in particular the ones derived from plant viruses and bacteriophages, are attractive options for cargo-delivery as they are biocompatible, biodegradable, and non-infectious to mammals...
April 17, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28424090/targeted-endomyocardial-biopsy-guided-by-real-time-cardiovascular-magnetic-resonance
#20
Christina Unterberg-Buchwald, Christian Oliver Ritter, Verena Reupke, Robin Niklas Wilke, Christine Stadelmann, Michael Steinmetz, Andreas Schuster, Gerd Hasenfuß, Joachim Lotz, Martin Uecker
BACKGROUND: Endomyocardial biopsies (EMB) are an important diagnostic tool for myocarditis and other infiltrative cardiac diseases. Routinely, biopsies are obtained under fluoroscopic guidance with a substantial radiation burden. Despite procedural success, there is a large sampling error caused by missing the affected myocardium. Therefore, multiple (>6) biopsies are taken in the clinical setting. In cardiovascular magnetic resonance (CMR), late gadolinium enhancement (LGE) depicts areas of affected myocardium in myocarditis or in other infiltrative cardiomyopathies...
April 19, 2017: Journal of Cardiovascular Magnetic Resonance
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