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Vijayalakshmi Padmanabhan, Heather B Steinmetz, Elizabeth J Rizzo, Amber J Erskine, Tamara L Fairbank, Francine B de Abreu, Gregory J Tsongalis, Laura J Tafe
CONTEXT: -At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core biopsy lung cancer samples. Two years ago the molecular diagnostics laboratory at our institution changed to next-generation sequencing using the Ion Torrent PGM and the 50-gene AmpliSeq Cancer Hotspot Panel v2 for analyzing mutations in a 50-gene cancer hot spot panel. This was associated with in a dramatic fall in adequacy rate (68%)...
October 20, 2016: Archives of Pathology & Laboratory Medicine
Lena-Marie Kortland, Anne Alfter, Oliver Bähr, Barbara Carl, Richard Dodel, Thomas M Freiman, Kristina Hubert, Kolja Jahnke, Susanne Knake, Felix von Podewils, Jens-Peter Reese, Uwe Runge, Christian Senft, Helmuth Steinmetz, Felix Rosenow, Adam Strzelczyk
OBJECTIVE: To provide first data on inpatient costs and cost-driving factors due to nonrefractory status epilepticus (NSE), refractory status epilepticus (RSE), and super-refractory status epilepticus (SRSE). METHODS: In 2013 and 2014, all adult patients treated due to status epilepticus (SE) at the university hospitals in Frankfurt, Greifswald, and Marburg were analyzed for healthcare utilization. RESULTS: We evaluated 341 admissions in 316 patients (65...
October 18, 2016: Epilepsia
Martin Steinmetz, Georg Nickenig, Tilman Sauerbruch, Florian Eyer, Christian Rabe
No abstract text is available yet for this article.
October 12, 2016: Clinical Toxicology
Ivan Zderic, Philipp Steinmetz, Markus Windolf, R Geoff Richards, Andreas Boger, Boyko Gueorguiev
Cement leakage is a serious adverse event potentially occurring during vertebroplasty. Pre-operative in-silico planning of the cement filling process can help reducing complication rates related to leakage. This requires a better understanding of the cement flow along the whole injection path. Therefore, the aim of the present study was to analyze bone cement flow behavior by stepwise injections through medical cannulas. Sixteen cannulas were assigned to four groups for stepwise injection of differently colored cement portions of 1ml volume...
October 7, 2016: Medical Engineering & Physics
Eva Heim, Holger Steinmetz, Matthew D Zeigenfuse, Andreas Maercker, Juergen Margraf
This study examined the circular structure of values in China. The circular structure is a central element of Schwartz value theory and visualises the idea that some values are similar while others conflict with one another. Whereas numerous studies addressed the question whether the circular structure of values can be generalised cross-culturally, results for China are inconclusive. In this paper, we argue that taking a closer look at China provides a challenge to the circular structure and allows for drawing conclusions regarding the limits versus generalizability of Schwartz' theory...
October 6, 2016: International Journal of Psychology: Journal International de Psychologie
Michael Costanzo, Benjamin VanderSluis, Elizabeth N Koch, Anastasia Baryshnikova, Carles Pons, Guihong Tan, Wen Wang, Matej Usaj, Julia Hanchard, Susan D Lee, Vicent Pelechano, Erin B Styles, Maximilian Billmann, Jolanda van Leeuwen, Nydia van Dyk, Zhen-Yuan Lin, Elena Kuzmin, Justin Nelson, Jeff S Piotrowski, Tharan Srikumar, Sondra Bahr, Yiqun Chen, Raamesh Deshpande, Christoph F Kurat, Sheena C Li, Zhijian Li, Mojca Mattiazzi Usaj, Hiroki Okada, Natasha Pascoe, Bryan-Joseph San Luis, Sara Sharifpoor, Emira Shuteriqi, Scott W Simpkins, Jamie Snider, Harsha Garadi Suresh, Yizhao Tan, Hongwei Zhu, Noel Malod-Dognin, Vuk Janjic, Natasa Przulj, Olga G Troyanskaya, Igor Stagljar, Tian Xia, Yoshikazu Ohya, Anne-Claude Gingras, Brian Raught, Michael Boutros, Lars M Steinmetz, Claire L Moore, Adam P Rosebrock, Amy A Caudy, Chad L Myers, Brenda Andrews, Charles Boone
We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments...
September 23, 2016: Science
Nathalie E Holz, Regina Boecker-Schlier, Arlette F Buchmann, Dorothea Blomeyer, Christine Jennen-Steinmetz, Sarah Baumeister, Michael M Plichta, Anna Cattrell, Gunter Schumann, Günter Esser, Martin Schmidt, Jan Buitelaar, Andreas Meyer-Lindenberg, Tobias Banaschewski, Daniel Brandeis, Manfred Laucht
Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated neural converging effects of CFA and CD in the same sample. At age 25 years, functional MRI data during two affective tasks, i.e. a reward (N = 171) and a face-matching paradigm (N = 181) and anatomical scans (N = 181) were acquired in right-handed currently healthy participants of an epidemiological study followed since birth...
October 2, 2016: Social Cognitive and Affective Neuroscience
Laura A Davis, Firas Dandachli, Robert Turcotte, Oren K Steinmetz
BACKGROUND: The standard of care for lower extremity soft tissue sarcoma (STS) is limb-sparing surgery. A small subset of these patients will require concomitant vascular reconstruction to ensure adequate resection and to preserve limb viability and function. The aim of this study was to evaluate outcomes in these patients with respect to wound healing and postoperative functional status. METHODS: Outcomes for a total of 154 patients treated for malignant lower extremity STS during an 8-year period between 2005 and 2013 were entered in a prospective registry...
September 26, 2016: Journal of Vascular Surgery
Cristina Manatschal, Ana-Maria Farcas, Miriam Steiner Degen, Mathias Bayer, Anil Kumar, Christiane Landgraf, Rudolf Volkmer, Yves Barral, Michel O Steinmetz
The Kar9 pathway promotes nuclear fusion during mating and spindle alignment during metaphase in budding yeast. How Kar9 supports the different outcome of these two divergent processes is an open question. Here, we show that three sites in the C-terminal disordered domain of Kar9 mediate tight Kar9 interaction with the C-terminal dimerization domain of Bim1 (EB1 orthologue). Site1 and Site2 contain SxIP motifs; however, Site3 defines a novel type of EB1-binding site. Whereas Site2 and Site3 mediate Kar9 recruitment to microtubule tips, nuclear movement and karyogamy, solely Site2 functions in spindle positioning during metaphase...
September 28, 2016: Molecular Biology of the Cell
R Kotecha, S Modugula, L Angelov, E C Benzel, C A Reddy, R Prayson, I Kalfas, R Schlenk, A Krishnaney, M Steinmetz, W Bingaman, J H Suh, S T Chao
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Vincent J Alentado, Stephanie Caldwell, Heath P Gould, Michael P Steinmetz, Edward C Benzel, Thomas E Mroz
BACKGROUND CONTEXT: Multiple studies have determined minimum clinically important difference (MCID) thresholds for EuroQOL-5 Dimensions (EQ-5D) scores in lumbar fusion patients. However, a comprehensive understanding of predictors for a CSI postoperatively does not exist. PURPOSE: To determine medical, radiographic and surgical predictors for obtaining a clinically significant improvement (CSI) following lumbar fusion surgery. STUDY DESIGN: Retrospective Review...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
Peter Steinmetz, Sharon Oleskevich
Family medicine ultrasound is more accurate, more cost-effective, and less time-consuming than you might imagine. Here's how it can improve your care.
August 2016: Journal of Family Practice
Sven O Dahms, Marcelino Arciniega, Torsten Steinmetzer, Robert Huber, Manuel E Than
Proprotein convertases (PCs) are highly specific proteases required for the proteolytic modification of many secreted proteins. An unbalanced activity of these enzymes is connected to pathologies like cancer, atherosclerosis, hypercholesterolaemia, and infectious diseases. Novel protein crystallographic structures of the prototypical PC family member furin in different functional states were determined to 1.8-2.0 Å. These, together with biochemical data and modeling by molecular dynamics calculations, suggest essential elements underlying its unusually high substrate specificity...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
Judit Pomothy, Gergely Szombath, Patrik Rokonál, Gábor Mátis, Zsuzsanna Neogrády, Torsten Steinmetzer, Erzsébet Pászti-Gere
Purpose. Dysfunction of matriptase-2 can be involved in iron regulatory disorder via downregulation of hepcidin expression. In the present study, we investigated the effects of 3-amidinophenylalanine-derived matriptase inhibitors on porcine hepatic inflammatory cell models. Methods. Hepatocyte-Kupffer cell cocultures (ratio of 2 : 1 and 6 : 1) were treated with four structurally related matriptase inhibitors at 50 μM. Cell cytotoxicity and relative expressions of IL-6 and IL-8 and the levels of hepcidin were determined by MTS and porcine-specific ELISA...
2016: BioMed Research International
Petar Simidzija, Michael J Lecours, Rick A Marta, Vincent Steinmetz, Terrance B McMahon, Eric Fillion, W Scott Hopkins
Hypercoordinated complexes involving tricarbastannatrane cation [N(CH2CH2CH2)3Sn](+) with various Lewis bases are investigated in the gas and solution phases using a combination of infrared multiple photon dissociation (IRMPD) spectroscopy, NMR spectroscopy, and density functional theory calculations. Coordination is found to occur at the apical position leading to a pentacoordinated Sn center. Strongly electron donating Lewis bases disrupt the N···Sn transannular interaction and induce higher degrees of geometric distortion at the metal center than weakly donating Lewis bases, an effect that manifests as anharmonic shifts in the vibrational spectra...
October 3, 2016: Inorganic Chemistry
Audrey Guesdon, Franck Bazile, Rubén M Buey, Renu Mohan, Solange Monier, Ruddi Rodríguez García, Morgane Angevin, Claire Heichette, Ralph Wieneke, Robert Tampé, Laurence Duchesne, Anna Akhmanova, Michel O Steinmetz, Denis Chrétien
EB1 is a microtubule plus-end tracking protein that recognizes GTP-tubulin dimers in microtubules and thus represents a unique probe to investigate the architecture of the GTP cap of growing microtubule ends. Here, we conjugated EB1 to gold nanoparticles (EB1-gold) and imaged by cryo-electron tomography its interaction with dynamic microtubules assembled in vitro from purified tubulin. EB1-gold forms comets at the ends of microtubules assembled in the presence of GTP, and interacts with the outer surface of curved and straight tubulin sheets as well as closed regions of the microtubule lattice...
October 2016: Nature Cell Biology
Jean-Paul Steinmetz, Claus Vögele, Christiane Theisen-Flies, Carine Federspiel, Stefan Sütterlin
The reliable measurement of quality of life (QoL) presents a challenge in individuals with alcohol-related brain damage. This study investigated vagally mediated heart rate variability (vmHRV) as a physiological predictor of QoL. Self- and proxy ratings of QoL and dysexecutive symptoms were collected once, while vmHRV was repeatedly assessed over a 3-week period at weekly intervals in a sample of nine alcohol-related brain damaged patients. We provide robustness checks, bootstrapped correlations with confidence intervals, and standard errors for mean scores...
2016: Psychology Research and Behavior Management
Silva Holtfreter, Dorothee Grumann, Veronika Balau, Annette Barwich, Julia Kolata, André Goehler, Stefan Weiss, Birte Holtfreter, Stephanie S Bauerfeind, Paula Döring, Erika Friebe, Nicole Haasler, Kristin Henselin, Katrin Kühn, Sophie Nowotny, Dörte Radke, Katrin Schulz, Sebastian R Schulz, Patricia Trübe, Chi Hai Vu, Birgit Walther, Susanne Westphal, Christiane Cuny, Wolfgang Witte, Henry Völzke, Hans Jörgen Grabe, Thomas Kocher, Ivo Steinmetz, Barbara M Bröker
Population-based studies on Staphylococcus aureus nasal colonization are scarce. We examined the prevalence, resistance and molecular diversity of S. aureus in the general population in Northeast Germany. Nasal swabs were obtained from 3891 adults in the large-scale population-based Study of Health in Pomerania (SHIP-TREND). Isolates were characterized using spa genotyping, as well as antibiotic resistance and virulence gene profiling. We observed an S. aureus prevalence of 27.2%. Nasal S. aureus carriage was associated with male sex and inversely correlated with age...
September 7, 2016: Journal of Clinical Microbiology
S Steinmetz, B Puliero, D Brinkert, N Meyer, P Adam, F Bonnomet, M Ehlinger
INTRODUCTION: Tibiofemoral syndesmosis injuries are common but have not been extensively researched. The primary objective of this study was to evaluate the outcomes after temporary screw fixation with ligament repair of these injuries. The secondary objective was to look for factors that could impact these outcomes. We hypothesised that this double fixation (screw+suture) would lead to good outcomes with minimal secondary opening of the syndesmosis upon screw removal. MATERIAL AND METHODS: This was a retrospective study of 285 patients with a tibiofemoral syndesmosis injury (01/2004-12/2011) who were treated by temporary tricortical or quadricortical screw fixation and ligament repair...
September 1, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Celine C Steinmetz, Vedakumar Tatavarty, Ken Sugino, Yasuyuki Shima, Anne Joseph, Heather Lin, Michael Rutlin, Mary Lambo, Chris M Hempel, Benjamin W Okaty, Suzanne Paradis, Sacha B Nelson, Gina G Turrigiano
Synaptic scaling is a form of homeostatic plasticity driven by transcription-dependent changes in AMPA-type glutamate receptor (AMPAR) trafficking. To uncover the pathways involved, we performed a cell-type-specific screen for transcripts persistently altered during scaling, which identified the μ subunit (μ3A) of the adaptor protein complex AP-3A. Synaptic scaling increased μ3A (but not other AP-3 subunits) in pyramidal neurons and redistributed dendritic μ3A and AMPAR to recycling endosomes (REs). Knockdown of μ3A prevented synaptic scaling and this redistribution, while overexpression (OE) of full-length μ3A or a truncated μ3A that cannot interact with the AP-3A complex was sufficient to drive AMPAR to REs...
September 6, 2016: Cell Reports
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