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https://www.readbyqxmd.com/read/28821444/circumferential-fusion-a-comparative-analysis-between-anterior-lumbar-interbody-fusion-with-posterior-pedicle-screw-fixation-and-transforaminal-lumbar-interbody-fusion-for-l5-s1-isthmic-spondylolisthesis
#1
Erik Y Tye, Joseph E Tanenbaum, Andrea S Alonso, Roy Xiao, Michael P Steinmetz, Thomas E Mroz, Jason W Savage
BACKGROUND CONTEXT: Transforaminal lumbar interbody fusion (TLIF) or anterior lumbar interbody fusion with percutaneous pedicle screws (ALIFPS) offer significantly higher radiographic fusion rates than other fusion techniques for L5-S1 isthmic spondylolisthesis (IS). As it stands, there is a relative paucity of comparative data of the two techniques. PURPOSE: To define the clinical, radiographic, and financial differences between TLIF and ALIFPS for L5-S1 IS. STUDY DESIGN/SETTING: A retrospective cohort study conducted at a single-tertiary care center...
August 15, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28814732/dual-contrast-magnetic-resonance-fingerprinting-dc-mrf-a-platform-for-simultaneous-quantification-of-multiple-mri-contrast-agents
#2
Christian E Anderson, Shannon B Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L Drumm, Susann M Brady-Kalnay, Nicole F Steinmetz, Xin Yu, Mark A Griswold, Chris A Flask
Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28814445/meeting-report-on-experimental-approaches-to-evolution-and-ecology-using-yeast-and-other-model-systems
#3
Daniel Jarosz, Aimée M Dudley
The fourth EMBO-sponsored conference on Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems (https://www.embl.de/training/events/2016/EAE16-01/), was held at the EMBL in Heidelberg, Germany, October 19-23, 2016. The conference was organized by Judith Berman (Tel Aviv University), Maitreya Dunham (University of Washington), Jun-Yi Leu (Academia Sinica), and Lars Steinmetz (EMBL Heidelberg and Stanford University). The meeting attracted ~120 researchers from 28 countries and covered a wide range of topics in the fields of genetics, evolutionary biology, and ecology with a unifying focus on yeast as a model system...
August 16, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28812378/bevacizumab-in-advanced-lung-cancer-state-of-the-art
#4
Sandra Assoun, Solenn Brosseau, Christelle Steinmetz, Valérie Gounant, Gérard Zalcman
Despite recent advances in metastatic lung cancer treatment with the advent of immune checkpoint inhibitors and molecules targeting addictive genomic abnormalities, prognosis of most of the patients remains unfavorable. Combination approaches with older drugs, such as bevacizumab, should be thus envisioned. Bevacizumab is a monoclonal anti-VEGF antibody, approved by the US FDA and the EMA in first-line and maintenance settings of advanced nonsquamous non-small-cell lung cancer (NSCLC) treatment, in association with platinum-based chemotherapy...
August 16, 2017: Future Oncology
https://www.readbyqxmd.com/read/28799610/viral-nanoparticles-decorated-with-novel-egfl7-ligands-enable-intravital-imaging-of-tumor-neovasculature
#5
Choi-Fong Cho, Lihai Yu, Tienabe K Nsiama, Alisha N Kadam, Arun Raturi, Sourabh Shukla, Giulio A Amadei, Nicole F Steinmetz, Leonard G Luyt, John D Lewis
Angiogenesis is a dynamic process fundamental to the development of solid tumors. Epidermal growth factor-like domain 7 (EGFL7) is a protein whose expression is restricted to endothelial cells undergoing active remodeling that has emerged as a key mediator of this process. EGFL7 expression is associated with poor outcome in several cancers, making it a promising target for imaging or therapeutic strategies. Here, EGFL7 is explored as a molecular target for active neovascularization. Using a combinatorial peptide screening approach, we describe the discovery and characterization of a novel high affinity EGFL7-binding peptide, E7p72, that specifically targets human endothelial cells...
August 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28781053/identification-of-chlamydomonas-central-core-centriolar-proteins-reveals-a-role-for-human-wdr90-in-ciliogenesis
#6
Virginie Hamel, Emmanuelle Steib, Romain Hamelin, Florence Armand, Susanne Borgers, Isabelle Flückiger, Coralie Busso, Natacha Olieric, Carlos Oscar S Sorzano, Michel O Steinmetz, Paul Guichard, Pierre Gönczy
Centrioles are evolutionarily conserved macromolecular structures that are fundamental to form cilia, flagella, and centrosomes. Centrioles are 9-fold symmetrical microtubule-based cylindrical barrels comprising three regions that can be clearly distinguished in the Chlamydomonas reinhardtii organelle: an ∼100-nm-long proximal region harboring a cartwheel; an ∼250-nm-long central core region containing a Y-shaped linker; and an ∼150-nm-long distal region ending at the transitional plate. Despite the discovery of many centriolar components, no protein has been localized specifically to the central core region in Chlamydomonas thus far...
July 29, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28780059/a-simple-laboratory-algorithm-for-diagnosis-of-melioidosis-in-resource-constrained-areas-a-study-from-north-central-vietnam
#7
T T Trinh, T S Hoang, D A Tran, V T Trinh, A Göhler, T T Nguyen, S N Hoang, R Krumkamp, L T N Nguyen, J May, P M Doan, C D Do, T A Que, I Steinmetz
OBJECTIVE: Melioidosis may be endemic in many tropical developing countries but diagnosis of the disease is currently unreliable in resource-limited areas. Here we aimed to validate a simple and cheap laboratory algorithm for the identification of Burkholderia pseudomallei from clinical specimens in parts of Vietnam where the disease has not been reported before. METHODS: In June 2015, we conducted training courses at five general hospitals in north central provinces in order to raise awareness of the disease and to introduce a simple and cheap laboratory identification algorithm for B...
August 2, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28776714/the-bonding-picture-in-hypervalent-xf3-x%C3%A2-%C3%A2-cl-br-i-at-fluorides-revisited-with-quantum-chemical-topology
#8
Mohamed Amaouch, Dumitru-Claudiu Sergentu, David Steinmetz, Rémi Maurice, Nicolas Galland, Julien Pilmé
Hypervalent XF3 (X = Cl, Br, I, At) fluorides exhibit T-shaped C2V equilibrium structures with the heavier of them, AtF3 , also revealing an almost isoenergetic planar D3h structure. Factors explaining this behavior based on simple "chemical intuition" are currently missing. In this work, we combine non-relativistic (ClF3 ), scalar-relativistic and two-component (X = Br - At) density functional theory calculations, and bonding analyses based on the electron localization function and the quantum theory of atoms in molecules...
August 3, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28760929/entry-intracellular-survival-and-multinucleated-giant-cell-forming-activity-of-burkholderia-pseudomallei-in-human-primary-phagocytic-and-non-phagocytic-cells
#9
Liam Whiteley, Teresa Meffert, Maria Haug, Christopher Weidenmaier, Verena Hopf, Katharina Bitschar, Birgit Schittek, Christian Kohler, Ivo Steinmetz, T Eoin West, Sandra Schwarz
The human pathogen Burkholderia pseudomallei and the related species Burkholderia thailandensis are facultative intracellular bacteria characterized by the ability to escape into the cytosol of the host cell and to stimulate the formation of multinucleated giant cells (MNGCs). MNGC formation is induced via an unknown mechanism by the bacterial type VI secretion system 5 (T6SS-5), which is an essential virulence factor in both species. Despite the vital role of the intracellular life cycle in the pathogenesis of the bacteria, the range of host cell types permissive for initiation and completion of the intracellular cycle is poorly defined...
July 31, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28760581/any-nonadherence-to-instructions-for-use-predicts-graft-related-adverse-events-in-patients-undergoing-elective-endovascular-aneurysm-repair
#10
Christine R Herman, Philippe Charbonneau, Kiattisak Hongku, Luc Dubois, Sajjid Hossain, Kevin Lee, Oren K Steinmetz
BACKGROUND: A variety of devices exist for endovascular aneurysm repair (EVAR). Device-specific instructions for use (IFU) detail anatomic constraints to application and deployment of devices and are developed from rigorous bench testing. Nonadherence to IFU occurs frequently to avoid open surgery. The purpose of this study was to determine if IFU violations are associated with increased risk of graft-related adverse events (GRAEs) during follow-up. METHODS: This multicenter retrospective observational study included patients undergoing elective endovascular repair for abdominal aneurysmal disease with three different devices...
July 28, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28759652/sleep-apnoea-is-common-in-severe-peripheral-arterial-disease
#11
Nadjib Schahab, Sarah Sudan, Christian Schaefer, Vedat Tiyerili, Martin Steinmetz, Georg Nickenig, Dirk Skowasch, Carmen Pizarro
BACKGROUND: Atherosclerotic conditions have been demonstrated to be associated with sleep- disordered breathing (SDB). Peripheral arterial disease (PAD) represents severe atherosclerosis with a high mortality. In early stages of PAD a substantial prevalence of sleep apnoea has already been shown. Here, we sought to determine the frequency of undiagnosed sleep apnoea in a homogeneous group of advanced PAD patients undergoing percutaneous revascularization. METHODS: 59 consecutive patients (mean age: 71...
2017: PloS One
https://www.readbyqxmd.com/read/28756574/impact-of-prenatal-stress-on-the-dyadic-behavior-of-mothers-and-their-6-month-old-infants-during-a-play-situation-role-of-different-dimensions-of-stress
#12
Isabell Ann-Cathrin Wolf, Maria Gilles, Verena Peus, Barbara Scharnholz, Julia Seibert, Christine Jennen-Steinmetz, Bertram Krumm, Michael Deuschle, Manfred Laucht
Prenatal stress (PS) is an established risk factor in the etiology of mental disorders. Although mother-child interaction is the infant's first important training in dealing with stress, little is yet known about the impact of PS on mother-infant dyadic behavior. The current study aimed to elucidate the prospective influence of psychological and physiological stresses during pregnancy on mother-infant dyadic behavior. Mother-infant interactions were videotaped at 6-month postpartum and coded into three dyadic patterns: (1) both positive; (2) infant protesting-mother positive; and (3) infant protesting-mother negative, using the infant and caregiver engagement phases...
July 29, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28752056/the-munich-midy-pig-biobank-a-unique-resource-for-studying-organ-crosstalk-in-diabetes
#13
Andreas Blutke, Simone Renner, Florian Flenkenthaler, Mattias Backman, Serena Haesner, Elisabeth Kemter, Erik Ländström, Christina Braun-Reichhart, Barbara Albl, Elisabeth Streckel, Birgit Rathkolb, Cornelia Prehn, Alessandra Palladini, Michal Grzybek, Stefan Krebs, Stefan Bauersachs, Andrea Bähr, Andreas Brühschwein, Cornelia A Deeg, Erica De Monte, Michaela Dmochewitz, Caroline Eberle, Daniela Emrich, Robert Fux, Frauke Groth, Sophie Gumbert, Antonia Heitmann, Arne Hinrichs, Barbara Keßler, Mayuko Kurome, Miriam Leipig-Rudolph, Kaspar Matiasek, Hazal Öztürk, Christiane Otzdorff, Myriam Reichenbach, Horst Dieter Reichenbach, Alexandra Rieger, Birte Rieseberg, Marco Rosati, Manuel Nicolas Saucedo, Anna Schleicher, Marlon R Schneider, Kilian Simmet, Judith Steinmetz, Nicole Übel, Patrizia Zehetmaier, Andreas Jung, Jerzy Adamski, Ünal Coskun, Martin Hrabě de Angelis, Christian Simmet, Mathias Ritzmann, Andrea Meyer-Lindenberg, Helmut Blum, Georg J Arnold, Thomas Fröhlich, Rüdiger Wanke, Eckhard Wolf
OBJECTIVE: The prevalence of diabetes mellitus and associated complications is steadily increasing. As a resource for studying systemic consequences of chronic insulin insufficiency and hyperglycemia, we established a comprehensive biobank of long-term diabetic INS(C94Y) transgenic pigs, a model of mutant INS gene-induced diabetes of youth (MIDY), and of wild-type (WT) littermates. METHODS: Female MIDY pigs (n = 4) were maintained with suboptimal insulin treatment for 2 years, together with female WT littermates (n = 5)...
August 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28745226/spatiotemporal-gait-characteristics-associated-with-cognitive-impairment-a-multicenter-cross-sectional-study-the-intercontinental-gait-cognition-decline-initiative
#14
Olivier Beauchet, Helena M Blumen, Michele L Callisaya, Anne-Marie De Cock, Reto W Kressig, Velandai Srikanth, Jean-Paul Steinmetz, Joe Verghese, Gilles Allali
BACKGROUND: The study aims to determine the spatiotemporal gait parameters and/or their combination(s) that best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia, regardless of the etiology of cognitive impairment. METHODS: A total of 2099 participants (1015 CHI, 478 patients with MCI, 301 patients with mild dementia and 275 with moderate dementia) were selected from the intercontinental "Gait, cOgnitiOn & Decline" (GOOD) initiative, which merged different databases from seven cross-sectional studies...
July 25, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28739479/emergency-department-visits-after-lumbar-spine-surgery-are-associated-with-lower-hcahps-scores
#15
Jay M Levin, Robert D Winkelman, Gabriel A Smith, Joseph E Tanenbaum, Roy Xiao, Thomas E Mroz, Michael P Steinmetz
BACKGROUND: Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) surveys are used to assess the quality of the patient experience following an inpatient stay. HCAHPS scores are used to determine reimbursement for hospital systems and incentivize spine surgeons nationwide. There are conflicting data detailing whether early readmission or other post-discharge complications are associated with patient responses on the HCAHPS survey. Currently, the association between post-discharge ED visits and HCAHPS scores following lumbar spine surgery is unknown...
July 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28719102/plant-viral-and-bacteriophage-delivery-of-nucleic-acid-therapeutics
#16
REVIEW
Patricia Lam, Nicole F Steinmetz
Nucleic acid therapeutics have emerged as a powerful method for treatment of many diseases. However, the challenge lies in safe and efficient delivery of nucleic acids to their target site, as they need to cross various extracellular and intracellular barriers. Mammalian viruses have initially been favored for delivery of nucleic acid therapeutics, but safety concerns regarding their immunogenicity and potential of integration have fueled the search for alternative delivery strategies. For example, chemistry and bioengineering have led to advances in the use of nonviral vectors composed of lipids and other polymers; nevertheless, the synthetic systems often do not match the efficiency achieved using the biological systems...
July 18, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28713172/poxylation-as-an-alternative-stealth-coating-for-biomedical-applications
#17
Herdis Bludau, Anna E Czapar, Andrzej S Pitek, Sourabh Shukla, Rainer Jordan, Nicole F Steinmetz
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodies indicates that this polymer has the potential to be immunogenic and antigenic. Here we present an alternative polymer, poly(2-oxazoline) (POx) for stealth applications, specifically shielding of a proteinaceous nanoparticle from recognition by the immune system. Tobacco mosaic virus (TMV) was used as our testbed due to its potential for use as a nanocarrier for drug delivery and molecular imaging applications...
March 2017: European Polymer Journal
https://www.readbyqxmd.com/read/28712562/abnormal-right-atrial-performance-in-repaired-tetralogy-of-fallot-a-cmr-feature-tracking-analysis
#18
Shelby Kutty, Quanliang Shang, Navya Joseph, Johannes T Kowallick, Andreas Schuster, Michael Steinmetz, David A Danford, Phillip Beerbaum, Samir Sarikouch
BACKGROUND: We hypothesized that right atrial (RA) performance is abnormal in repaired tetralogy of Fallot (TOF). METHODS: TOF patients were prospectively enrolled for cardiovascular magnetic resonance (CMR), echocardiography and exercise stress following a standardized 14-center protocol. Peak RA longitudinal strain (RALS) and right ventricular longitudinal strain (RVLS) were measured using CMR feature tracking (FT) and correlated to RA and RV end diastolic volumes (EDVi) and ejection fraction (EF)...
July 8, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28711277/use-of-a-midstream-clean-catch-mobile-application-did-not-lower-urine-contamination-rates-in-an-emergency-department
#19
Mary S Jacob, Paige Kulie, Cameron Benedict, Alexander J Ordoobadi, Neal Sikka, Erika Steinmetz, Melissa L McCarthy
OBJECTIVES: Urine microscopy is a common test performed in emergency departments (EDs). Urine specimens can easily become contaminated by different factors, including the collection method. The midstream clean-catch (MSCC) collection technique is commonly used to reduce urine contamination. The urine culture contamination rate from specimens collected in our ED is 30%. We developed an instructional application (app) to show ED patients how to provide a MSCC urine sample. We hypothesized that ED patients who viewed our instructional app would have significantly lower urine contamination rates compared to patients who did not...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28709431/is-gentrification-all-bad-positive-association-between-gentrification-and-individual-s-perceived-neighborhood-collective-efficacy-in-montreal-canada
#20
Madeleine Steinmetz-Wood, Rania Wasfi, George Parker, Lisa Bornstein, Jean Caron, Yan Kestens
BACKGROUND: Collective efficacy has been associated with many health benefits at the neighborhood level. Therefore, understanding why some communities have greater collective efficacy than others is important from a public health perspective. This study examined the relationship between gentrification and collective efficacy, in Montreal Canada. METHODS: A gentrification index was created using tract level median household income, proportion of the population with a bachelor's degree, average rent, proportion of the population with low income, and proportion of the population aged 30-44...
July 14, 2017: International Journal of Health Geographics
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