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https://www.readbyqxmd.com/read/27908325/-using-a-high-inspiratory-oxygen-fraction-during-surgery
#1
Trine Grodum Eskesen, Jacob Steinmetz, Lars S Rasmussen
In this article we discuss the current level of evidence for using a high inspiratory oxygen fraction (0.60-0.90) during surgery. More than 7,000 patients have been included in randomized trials, but no significant beneficial effect was found in a recent meta-analysis as compared with 0.30-0.40 oxygen. A high oxygen fraction should be used to correct or prevent hypoxaemia in special situations, but the available studies do not allow a recommendation to use a high inspiratory oxygen fraction as a routine practice in surgical patients...
November 28, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27906129/the-evolutionary-origin-of-bilaterian-smooth-and-striated-myocytes
#2
Thibaut Brunet, Antje Hl Fischer, Patrick Rh Steinmetz, Antonella Lauri, Paola Bertucci, Detlev Arendt
The dichotomy between smooth and striated myocytes is fundamental for bilaterian musculature, but its evolutionary origin is unsolved. In particular, interrelationships of visceral smooth muscles remain unclear. Absent in fly and nematode, they have not yet been characterized molecularly outside vertebrates. Here, we characterize expression profile, ultrastructure, contractility and innervation of the musculature in the marine annelid Platynereis dumerilii and identify smooth muscles around the midgut, hindgut and heart that resemble their vertebrate counterparts in molecular fingerprint, contraction speed, and nervous control...
December 1, 2016: ELife
https://www.readbyqxmd.com/read/27892458/modulation-of-mrna-and-lncrna-expression-dynamics-by-the-set2-rpd3s-pathway
#3
Ji Hyun Kim, Bo Bae Lee, Young Mi Oh, Chenchen Zhu, Lars M Steinmetz, Yookyeong Lee, Wan Kyu Kim, Sung Bae Lee, Stephen Buratowski, TaeSoo Kim
H3K36 methylation by Set2 targets Rpd3S histone deacetylase to transcribed regions of mRNA genes, repressing internal cryptic promoters and slowing elongation. Here we explore the function of this pathway by analysing transcription in yeast undergoing a series of carbon source shifts. Approximately 80 mRNA genes show increased induction upon SET2 deletion. A majority of these promoters have overlapping lncRNA transcription that targets H3K36me3 and deacetylation by Rpd3S to the mRNA promoter. We previously reported a similar mechanism for H3K4me2-mediated repression via recruitment of the Set3C histone deacetylase...
November 28, 2016: Nature Communications
https://www.readbyqxmd.com/read/27880975/ror%C3%AE-t-expression-in-tregs-promotes-systemic-lupus-erythematosus-via-il-17-secretion-alteration-of-treg-phenotype-and-suppression-of-th2-responses
#4
Malte A Kluger, Anna Nosko, Torben Ramcke, Boeren Goerke, Matthias C Meyer, Claudia Wegscheid, Michael Luig, Gisa Tiegs, Rolf A K Stahl, Oliver M Steinmetz
Systemic lupus erythematosus (SLE) is a common autoimmune disorder with a complex and poorly understood immuno-pathogenesis. However, a pathogenic role for the Th17 axis was demonstrated by many studies, while Tregs were shown to mediate protection. Recently, we and others characterized a novel and independent T cell population expressing both, the Treg characteristic transcription factor Foxp3 and the Th17 defining RORγt. Studies in a model of acute glomerulonephritis unveiled potent regulatory, but in addition also pro-inflammatory functions of RORγt(+) Foxp3(+) Tregs...
November 23, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27866105/pilot-scale-removal-and-recovery-of-dissolved-phosphate-from-secondary-wastewater-effluents-with-reusable-znfezr-adsorbent-fe3o4-sio2-particles-with-magnetic-harvesting
#5
Asya Drenkova-Tuhtan, Michael Schneider, Matthias Franzreb, Carsten Meyer, Carsten Gellermann, Gerhard Sextl, Karl Mandel, Heidrun Steinmetz
Advanced nanocomposite magnetic particles functionalized with ZnFeZr-adsorbent are developed, characterized and tested for the removal and recovery of phosphate directly from spiked secondary wastewater effluent (∼10 mg/L PO4-P). The phosphate loaded particles can be extracted from the liquid phase via magnetic separation, regenerated in a NaOH solution where phosphate desorption takes place, and reused in numerous cycles. Laboratory experiments demonstrate their reusability and stability in 60 consecutive adsorption/desorption runs where under optimal conditions > 90% total P-recovery efficiency is reached...
November 14, 2016: Water Research
https://www.readbyqxmd.com/read/27856798/the-synthetic-diazonamide-dz-2384-has-distinct-effects-on-microtubule-curvature-and-dynamics-without-neurotoxicity
#6
Michal Wieczorek, Joseph Tcherkezian, Cynthia Bernier, Andrea E Prota, Sami Chaaban, Yannève Rolland, Claude Godbout, Mark A Hancock, Joseph C Arezzo, Ozhan Ocal, Cecilia Rocha, Natacha Olieric, Anita Hall, Hui Ding, Alexandre Bramoullé, Matthew G Annis, George Zogopoulos, Patrick G Harran, Thomas M Wilkie, Rolf A Brekken, Peter M Siegel, Michel O Steinmetz, Gordon C Shore, Gary J Brouhard, Anne Roulston
Microtubule-targeting agents (MTAs) are widely used anticancer agents, but toxicities such as neuropathy limit their clinical use. MTAs bind to and alter the stability of microtubules, causing cell death in mitosis. We describe DZ-2384, a preclinical compound that exhibits potent antitumor activity in models of multiple cancer types. It has an unusually high safety margin and lacks neurotoxicity in rats at effective plasma concentrations. DZ-2384 binds the vinca domain of tubulin in a distinct way, imparting structurally and functionally different effects on microtubule dynamics compared to other vinca-binding compounds...
November 16, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27851911/autoimmune-renal-disease-is-exacerbated-by-s1p-receptor-1-dependent-intestinal-th17-cell-migration-to-the-kidney
#7
Christian F Krebs, Hans-Joachim Paust, Sonja Krohn, Tobias Koyro, Silke R Brix, Jan-Hendrik Riedel, Patricia Bartsch, Thorsten Wiech, Catherine Meyer-Schwesinger, Jiabin Huang, Nicole Fischer, Philipp Busch, Hans-Willi Mittrücker, Ulrich Steinhoff, Brigitta Stockinger, Laura Garcia Perez, Ulrich O Wenzel, Matthias Janneck, Oliver M Steinmetz, Nicola Gagliani, Rolf A K Stahl, Samuel Huber, Jan-Eric Turner, Ulf Panzer
Th17 cells are most abundant in the gut, where their presence depends on the intestinal microbiota. Here, we examined whether intestinal Th17 cells contribute to extra-intestinal Th17 responses in autoimmune kidney disease. We found high frequencies of Th17 cells in the kidneys of patients with antineutrophil cytoplasmatic antibody (ANCA)-associated glomerulonephritis. We utilized photoconversion of intestinal cells in Kaede mice to track intestinal T cell mobilization upon glomerulonephritis induction, and we found that Th17 cells egress from the gut in a S1P-receptor-1-dependent fashion and subsequently migrate to the kidney via the CCL20/CCR6 axis...
November 15, 2016: Immunity
https://www.readbyqxmd.com/read/27849238/diabetes-mellitus-in-childhood-an-emerging-condition-in-the-21st-century
#8
Thais Della Manna, Nuvarte Setian, Roberta Diaz Savoldelli, Dulce Rondina Guedes, Hilton Kuperman, Hamilton Cabral Menezes, Leandra Steinmetz, Louise Cominato, Vaê Dichtchekenian, Durval Damiani
The International Diabetes Federation (IDF-2015) estimates the existence of 30,900 children under 15 years old with type 1 diabetes mellitus (DM1) in Brazil, and an increase of 3.0% per year is expected. This review focused on meta-analysis and pediatric diabetes update articles in order to draw attention to the need of planning coping strategies to support this serious public health problem in coming years. DM1 is considered an immuno-mediated disease with a complex transmission influenced by genetic and environmental factors responsible for a gradual destruction of the insulin producing pancreatic beta cells...
September 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27849181/nadph-oxidase-contributes-to-resistance-against-aggregatibacter-actinomycetemcomitans-induced-periodontitis-in-mice
#9
Antje Bast, Helen Kubis, Birte Holtfreter, Silvia Ribback, Heiner Martin, Helen C Schreiner, Malte J Dominik, Katrin Breitbach, Frank Dombrowski, Thomas Kocher, Ivo Steinmetz
Aggregatibacter actinomycetemcomitans is a Gram-negative commensal bacterium of the oral cavity which has been associated with the pathogenesis of periodontitis with severe alveolar bone destruction. The role of host factors such as reactive oxygen and nitrogen intermediates in periodontal A. actinomycetemcomitans infection and progression to periodontitis is still ill-defined. Therefore, this study aimed to analyse the role of NADPH oxidase and inducible nitric oxide synthase (iNOS) in a murine model of A...
November 14, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27822087/the-danish-database-for-acute-and-emergency-hospital-contacts
#10
REVIEW
Annmarie T Lassen, Henrik Jørgensen, Hanne Blæhr Jørsboe, Annette Odby, Mikkel Brabrand, Jacob Steinmetz, Julie Mackenhauer, Hans Kirkegaard, Christian Fynbo Christiansen
AIM FOR DATABASE: Aim of the Danish database for acute and emergency hospital contacts (DDAEHC) is to monitor the quality of care for all unplanned hospital contacts in Denmark (acute and emergency contacts). STUDY POPULATION: The DDAEHC is a nationwide registry that completely covers all acute and emergency somatic hospital visits at individual level regardless of presentation site, presenting complaint, and department designation since January 1, 2013. MAIN VARIABLES: The DDAEHC includes ten quality indicators - of which two are outcome indicators and eight are process indicators...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27818269/cannabinoid-modulation-of-memory-consolidation-within-the-cerebellum
#11
Adam B Steinmetz, John H Freeman
Cannabinoid receptors contribute to learning and synaptic plasticity mechanisms. The cerebellum contains a high density of cannabinoid receptors and manipulations of cannabinoid receptors affect synaptic plasticity within the cerebellar cortex. In vivo studies have found that cannabinoid agonists impair learning of cerebellum-dependent eyeblink conditioning in rodents and humans. However, the role of cannabinoid receptors or endocannabinoids in memory consolidation within the cerebellum has not been examined...
December 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/27798767/practical-management-of-anaesthesia-in-the-elderly
#12
Camilla Strøm, Lars Simon Rasmussen, Jacob Steinmetz
The elderly population is rapidly growing and particularly diverse. Ageing leads to reduced organ function and a decline in physiologic reserve. Elderly patients are characterised by great inter-individual variability in physiological function with a high prevalence of chronic disease. In general, older patients have a higher risk of postoperative adverse outcomes, and frailty is a very important risk factor. This review article aims to provide a practical guide to anaesthetic management of the elderly surgical patient...
October 31, 2016: Drugs & Aging
https://www.readbyqxmd.com/read/27789525/a-privacy-preserving-solution-for-compressed-storage-and-selective-retrieval-of-genomic-data
#13
Zhicong Huang, Erman Ayday, Huang Lin, Raeka S Aiyar, Adam Molyneaux, Zhenyu Xu, Jacques Fellay, Lars M Steinmetz, Jean-Pierre Hubaux
In clinical genomics, the continuous evolution of bioinformatic algorithms and sequencing platforms makes it beneficial to store patients' complete aligned genomic data in addition to variant calls relative to a reference sequence. Due to the large size of human genome sequence data files (varying from 30GB to 200GB depending on coverage), two major challenges facing genomics laboratories are the costs of storage and the efficiency of the initial data processing. In addition, privacy of genomic data is becoming an increasingly serious concern; yet no standard data storage solutions exist that enable compression, encryption, and selective retrieval...
October 27, 2016: Genome Research
https://www.readbyqxmd.com/read/27788063/how-medicaid-and-other-public-policies-affect-use-of-tobacco-cessation-therapy-united-states-2010-2014
#14
Leighton Ku, Erin Brantley, Tyler Bysshe, Erika Steinmetz, Brian K Bruen
INTRODUCTION: State Medicaid programs can cover tobacco cessation therapies for millions of low-income smokers in the United States, but use of this benefit is low and varies widely by state. This article assesses the effects of changes in Medicaid benefit policies, general tobacco policies, smoking norms, and public health programs on the use of cessation therapy among Medicaid smokers. METHODS: We used longitudinal panel analysis, using 2-way fixed effects models, to examine the effects of changes in state policies and characteristics on state-level use of Medicaid tobacco cessation medications from 2010 through 2014...
October 27, 2016: Preventing Chronic Disease
https://www.readbyqxmd.com/read/27778120/monitoring-of-abdominal-staphylococcus-aureus-infection-using-magnetic-resonance-imaging-a-murine-animal-model-for-hepatic-and-renal-abscesses
#15
M L Kromrey, A Göhler, N Friedrich, K Kindermann, S Hadlich, D Puls, I Steinmetz, J P Kühn
To establish a routine workflow for in vivo magnetic resonance imaging (MRI) of mice infected with bacterial biosafety level 2 pathogens and to generate a mouse model for systemic infection with Staphylococcus aureus suitable for monitoring by MRI. A self-contained acrylic glass animal bed complying with biosafety level 2 requirements was constructed. After intravenous infection with 10(5) colony-forming units (CFU) (n = 3), 10(6) CFU (n = 11) or 10(7) CFU (n = 6) of S. aureus strain Newman, female Balb/c mice were whole-body scanned by 7T MRI...
October 24, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27776940/psoas-muscle-area-predicts-all-cause-mortality-after-endovascular-and-open-aortic-aneurysm-repair
#16
L M Drudi, K Phung, M Ades, J Zuckerman, L Mullie, O K Steinmetz, D I Obrand, J Afilalo
OBJECTIVE: Psoas muscle area (PMA) is a validated surrogate for muscle mass that can be easily measured from a clinical CT scan. This study sought to determine whether PMA was associated with post-operative mortality after endovascular or open aortic aneurysm repair. METHODS: A retrospective review was undertaken of patients who underwent elective endovascular or open aortic aneurysm repair between 2010 and 2015 at a tertiary vascular center in Montreal, Quebec, Canada...
October 21, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27763790/improving-adequacy-of-small-biopsy-and-fine-needle-aspiration-specimens-for-molecular-testing-by-next-generation-sequencing-in-patients-with-lung-cancer-a-quality-improvement-study-at-dartmouth-hitchcock-medical-center
#17
Vijayalakshmi Padmanabhan, Heather B Steinmetz, Elizabeth J Rizzo, Amber J Erskine, Tamara L Fairbank, Francine B de Abreu, Gregory J Tsongalis, Laura J Tafe
CONTEXT: -At our medical center, cytopathologists perform rapid on-site evaluation for specimen adequacy of fine-needle aspiration and touch imprint of needle core biopsy lung cancer samples. Two years ago the molecular diagnostics laboratory at our institution changed to next-generation sequencing using the Ion Torrent PGM and the 50-gene AmpliSeq Cancer Hotspot Panel v2 for analyzing mutations in a 50-gene cancer hot spot panel. This was associated with in a dramatic fall in adequacy rate (68%)...
October 20, 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27753082/costs-and-cost-driving-factors-for-acute-treatment-of-adults-with-status-epilepticus-a-multicenter-cohort-study-from-germany
#18
Lena-Marie Kortland, Anne Alfter, Oliver Bähr, Barbara Carl, Richard Dodel, Thomas M Freiman, Kristina Hubert, Kolja Jahnke, Susanne Knake, Felix von Podewils, Jens-Peter Reese, Uwe Runge, Christian Senft, Helmuth Steinmetz, Felix Rosenow, Adam Strzelczyk
OBJECTIVE: To provide first data on inpatient costs and cost-driving factors due to nonrefractory status epilepticus (NSE), refractory status epilepticus (RSE), and super-refractory status epilepticus (SRSE). METHODS: In 2013 and 2014, all adult patients treated due to status epilepticus (SE) at the university hospitals in Frankfurt, Greifswald, and Marburg were analyzed for healthcare utilization. RESULTS: We evaluated 341 admissions in 316 patients (65...
October 18, 2016: Epilepsia
https://www.readbyqxmd.com/read/27728980/effect-of-hemoperfusion-on-flecainide-serum-concentration-a-case-report
#19
Martin Steinmetz, Georg Nickenig, Tilman Sauerbruch, Florian Eyer, Christian Rabe
No abstract text is available yet for this article.
October 12, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27727118/bone-cement-flow-analysis-by-stepwise-injection-through-medical-cannulas
#20
Ivan Zderic, Philipp Steinmetz, Markus Windolf, R Geoff Richards, Andreas Boger, Boyko Gueorguiev
Cement leakage is a serious adverse event potentially occurring during vertebroplasty. Pre-operative in-silico planning of the cement filling process can help reducing complication rates related to leakage. This requires a better understanding of the cement flow along the whole injection path. Therefore, the aim of the present study was to analyze bone cement flow behavior by stepwise injections through medical cannulas. Sixteen cannulas were assigned to four groups for stepwise injection of differently colored cement portions of 1ml volume...
October 7, 2016: Medical Engineering & Physics
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