keyword
https://read.qxmd.com/read/38532056/inter-coat-protein-loading-of-active-ingredients-into-tobacco-mild-green-mosaic-virus-through-partial-dissociation-and-reassembly-of-the-virion
#1
JOURNAL ARTICLE
Ivonne González-Gamboa, Adam A Caparco, Justin McCaskill, Paulina Fuenlabrada-Velázquez, Samuel S Hays, Zhicheng Jin, Jesse V Jokerst, Jonathan K Pokorski, Nicole F Steinmetz
Chemical pesticide delivery is a fundamental aspect of agriculture. However, the extensive use of pesticides severely endangers the ecosystem because they accumulate on crops, in soil, as well as in drinking and groundwater. New frontiers in nano-engineering have opened the door for precision agriculture. We introduced Tobacco mild green mosaic virus (TMGMV) as a viable delivery platform with a high aspect ratio and favorable soil mobility. In this work, we assess the use of TMGMV as a chemical nanocarrier for agriculturally relevant cargo...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531326/improvement-in-echocardiographic-indexes-of-systolic-heart-failure-post-kidney-transplantation-a-retrospective-analysis
#2
JOURNAL ARTICLE
Keren Skalsky, Leor Perl, Benaya Rozen Zvi, Mohamad Atamna, Ran Kornowski, Eviatar Nesher, Ruth Rahamimov, Tuvia Ben Gal, Yaron Shapira, Arthur Shyovich, Tali Steinmetz
INTRODUCTION: End-stage renal disease (ESRD) is a major risk factor for cardiovascular morbidity and mortality, which can be partially eliminated by kidney transplantation. Systolic heart failure might be considered as contraindication for kidney transplant although some patients demonstrate myocardial recovery post-transplant. We aim to identify and characterize the phenomenon of reverse myocardial remodelling in kidney transplanted patients. METHODS: The study is a retrospective cohort of patients undergoing kidney transplant between 2016-2019 (n=604) at Rabin Medical Center...
March 26, 2024: Cardiology
https://read.qxmd.com/read/38522946/prolonged-duration-of-action-of-suxamethonium-in-pregnant-and-postpartum-patients-a-registry-study
#3
JOURNAL ARTICLE
Helene Dalsten, Vera Crone, Jacob Steinmetz, Christine L Rosager, Lars S Rasmussen, Matias Vested
BACKGROUND: Suxamethonium is hydrolysed by butyrylcholinesterase (BChE) and a low BChE activity can result in a prolonged duration of action of suxamethonium. The BChE activity is reduced during pregnancy and postpartum period by up to 33%. However, it can also be reduced by mutations in the BChE gene. In this study, we assessed BChE activity and mutations in the BChE gene in pregnant and postpartum patients with prolonged duration of action of suxamethonium. It was hypothesised that at least 30% of patients with a low BChE activity did not have a mutation in the BChE gene...
March 24, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38521903/isolation-of-burkholderia-pseudomallei-from-a-goat-in-new-caledonia-implications-for-animal-and-human-health-monitoring-and-serological-tool-comparison
#4
JOURNAL ARTICLE
Anais Desoutter, Thomas Deshayes, Fabien Vorimore, Bernice Klotoe, Benoit Durand, Julien Colot, Gabriel Wagner-Lichtenegger, Ivo Steinmetz, Apichai Tuanyok, Karine Laroucau
BACKGROUND: Melioidosis is a serious bacterial infection caused by Burkholderia pseudomallei, a gram-negative bacterium commonly found in soil and water. It can affect both humans and animals, and is endemic in regions such as Southeast Asia and Northern Australia. In recent years, there have been reports of an emergence of human melioidosis in other areas, including New Caledonia. RESULTS: During standard laboratory analysis in New Caledonia in 2021, a strain of B...
March 23, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38521612/deep-learning-accelerated-brain-diffusion-weighted-mri-with-super-resolution-processing
#5
JOURNAL ARTICLE
Sebastian Altmann, Nils F Grauhan, Mario Alberto Abello Mercado, Sebastian Steinmetz, Andrea Kronfeld, Roman Paul, Thomas Benkert, Timo Uphaus, Sergiu Groppa, Yaroslav Winter, Marc A Brockmann, Ahmed E Othman
OBJECTIVES: To investigate the clinical feasibility and image quality of accelerated brain diffusion-weighted imaging (DWI) with deep learning image reconstruction and super resolution. METHODS: 85 consecutive patients with clinically indicated MRI at a 3 T scanner were prospectively included. Conventional diffusion-weighted data (c-DWI) with four averages were obtained. Reconstructions of one and two averages, as well as deep learning diffusion-weighted imaging (DL-DWI), were accomplished...
March 22, 2024: Academic Radiology
https://read.qxmd.com/read/38518920/a-retrospective-analysis-of-perioperative-complications-of-lateral-approach-lumbar-interbody-fusion-in-patients-with-prior-abdominal-surgery-or-a-history-of-colonic-inflammatory-disease
#6
JOURNAL ARTICLE
Michael D Shost, Edward Barksdale, Mina Huerta, Karrington Seals, Nicholas Rabah, Bilal Butt, Michael Steinmetz
BACKGROUND CONTEXT: Lateral approaches for lumbar interbody fusion (LIF) allow for access to the lumbar spine and disk space by passing through a retroperitoneal corridor either pre- or trans-psoas. A contraindication for this approach is the presence of retroperitoneal scarring that may occur from prior surgical intervention in the retroperitoneal space or from inflammatory conditions with fibrotic changes and pose challenges for the mobilization and visualization needed in this approach...
March 20, 2024: Spine Journal: Official Journal of the North American Spine Society
https://read.qxmd.com/read/38518282/exploring-tribology-and-material-contact-science-in-spine-surgery-implications-for-implant-design
#7
JOURNAL ARTICLE
Gabrielle Scariano, Seth Meade, Assem Sultan, Michael Shost, Edward C Benzel, Ajit Krishnaney, Thomas Mroz, Michael P Steinmetz, Ghaith Habboub
Tribology, an interdisciplinary field concerned with the science of interactions between surfaces in contact and their relative motion, plays a well-established role in the design of orthopedic implants, such as knee and hip replacements. However, its applications in spine surgery have received comparatively less attention in the literature. Understanding tribology is pivotal in elucidating the intricate interactions between metal, polymer, and ceramic components, as well as their interplay with the native human bone...
March 22, 2024: Journal of Neurosurgery. Spine
https://read.qxmd.com/read/38496526/the-spiking-output-of-the-mouse-olfactory-bulb-encodes-large-scale-temporal-features-of-natural-odor-environments
#8
Suzanne M Lewis, Lucas M Suarez, Nicola Rigolli, Nicholas A Steinmetz, David H Gire
Spatiotemporal dynamics of natural odor environment have informative features for animals navigating to an odor source. Population activity in the olfactory bulb (OB) has been shown to follow plume dynamics to a moderate degree (Lewis et al., 2021), but it is unknown whether the ability to follow plume dynamics is driven by individual cells or whether it emerges at the population level. Previous research has explored the responses of individual OB cells to isolated features of plumes, but it is difficult to adequately sample these features as it is still undetermined which features navigating mice employ during olfactory guided search...
March 5, 2024: bioRxiv
https://read.qxmd.com/read/38487227/modular-synthesis-of-functional-libraries-by-accelerated-sufex-click-chemistry
#9
JOURNAL ARTICLE
Joshua A Homer, Rebecca A Koelln, Andrew S Barrow, Timothy L Gialelis, Zlata Boiarska, Nikita S Steinohrt, Erinna F Lee, Wen-Hsuan Yang, Robert M Johnson, Taemoon Chung, Amber N Habowski, Dharmendra S Vishwakarma, Debmalya Bhunia, Charlotte Avanzi, Adam D Moorhouse, Mary Jackson, David A Tuveson, Scott K Lyons, Michael J Lukey, W Douglas Fairlie, Shozeb M Haider, Michel O Steinmetz, Andrea E Prota, John E Moses
Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and exceptional product yields, ASCC streamlines the synthetic workflow, simplifies the purification process, and is ideally suited for discovering functional molecules. We showcase the versatility and practicality of the ASCC reaction as a tool for the late-stage derivatization of bioactive molecules and in the array synthesis of sulfonate-linked, high-potency, microtubule targeting agents (MTAs) that exhibit nanomolar anticancer activity against multidrug-resistant cancer cell lines...
March 13, 2024: Chemical Science
https://read.qxmd.com/read/38485134/digital-cognitive-behavioural-therapy-for-insomnia-reduces-insomnia-in-nurses-suffering-from-shift-work-disorder-a-randomised-controlled-pilot-trial
#10
JOURNAL ARTICLE
Johanna Ell, Hanna A Brückner, Anna F Johann, Lisa Steinmetz, Lara J Güth, Bernd Feige, Heli Järnefelt, Annie Vallières, Lukas Frase, Katharina Domschke, Dieter Riemann, Dirk Lehr, Kai Spiegelhalder
Insomnia is a primary symptom of shift work disorder, yet it remains undertreated. This randomised-controlled pilot trial examined the efficacy of a digital, guided cognitive behavioural therapy for insomnia adapted to shift work (SleepCare) in nurses with shift work disorder. The hypothesis was that SleepCare reduces insomnia severity compared with a waitlist control condition. A total of 46 unmedicated nurses suffering from shift work disorder with insomnia (age: 39.7 ± 12.1 years; 80...
March 14, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38470058/ace2-acts-as-a-novel-regulator-of-tmprss2-catalyzed-proteolytic-activation-of-influenza-a-virus-in-airway-cells
#11
JOURNAL ARTICLE
Miriam Ruth Heindl, Anna-Lena Rupp, Marie Schwerdtner, Dorothea Bestle, Anne Harbig, Amy De Rocher, Luna C Schmacke, Bart Staker, Torsten Steinmetzer, David A Stein, Hong M Moulton, Eva Böttcher-Friebertshäuser
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses including influenza A virus (IAV), parainfluenza viruses, and various coronaviruses for membrane fusion. Previous studies showed that TMPRSS2 interacts with the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), a cell surface protein that serves as an entry receptor for some coronaviruses. Here, by using protease activity assays, we determine that ACE2 increases the enzymatic activity of TMPRSS2 in a non-catalytic manner...
March 12, 2024: Journal of Virology
https://read.qxmd.com/read/38465197/irgd-targeted-physalis-mottle-virus-like-nanoparticles-for-targeted-cancer-delivery
#12
JOURNAL ARTICLE
Krister J Barkovich, Zhongchao Zhao, Nicole F Steinmetz
Nanomedicine provides a promising platform for the molecular treatment of disease. An ongoing challenge in nanomedicine is the targeted delivery of intravenously administered nanoparticles to particular tissues, which is of special interest in cancer. In this study, we show that the conjugation of iRGD peptides, which specifically target tumor neovasculature, to the surface of Physalis mottle virus (PhMV)-like nanoparticles leads to rapid cellular uptake in vitro and tumor homing in vivo . We then show that iRGD-targeted PhMV loaded with the chemotherapeutic doxorubicin shows increased potency in a murine flank xenograft model of cancer...
August 2023: Small science
https://read.qxmd.com/read/38461217/global-estimates-on-the-number-of-people-blind-or-visually-impaired-by-cataract-a-meta-analysis-from-2000-to-2020
#13
JOURNAL ARTICLE
Konrad Pesudovs, Van Charles Lansingh, John H Kempen, Ian Tapply, Arthur G Fernandes, Maria V Cicinelli, Alessandro Arrigo, Nicolas Leveziel, Paul Svitil Briant, Theo Vos, Serge Resnikoff, Hugh R Taylor, Tabassom Sedighi, Seth Flaxman, Jaimie Steinmetz, Rupert Bourne
BACKGROUND: To estimate global and regional trends from 2000 to 2020 of the number of persons visually impaired by cataract and their proportion of the total number of vision-impaired individuals. METHODS: A systematic review and meta-analysis of published population studies and gray literature from 2000 to 2020 was carried out to estimate global and regional trends. We developed prevalence estimates based on modeled distance visual impairment and blindness due to cataract, producing location-, year-, age-, and sex-specific estimates of moderate to severe vision impairment (MSVI presenting visual acuity <6/18, ≥3/60) and blindness (presenting visual acuity <3/60)...
March 9, 2024: Eye
https://read.qxmd.com/read/38448994/characteristics-and-critical-care-interventions-in-drowning-patients-treated-by-the-danish-air-ambulance-from-2016-to-2021-a-nationwide-registry-based-study-with-30-day-follow-up
#14
JOURNAL ARTICLE
Niklas Breindahl, Signe A Wolthers, Thea P Møller, Stig N F Blomberg, Jacob Steinmetz, Helle C Christensen
BACKGROUND: Improving oxygenation and ventilation in drowning patients early in the field is critical and may be lifesaving. The critical care interventions performed by physicians in drowning management are poorly described. The aim was to describe patient characteristics and critical care interventions with 30-day mortality as the primary outcome in drowning patients treated by the Danish Air Ambulance. METHODS: This retrospective cohort study with 30-day follow-up identified drowning patients treated by the Danish Air Ambulance from January 1, 2016, through December 31, 2021...
March 6, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38445550/covid-19-infection-in-patients-with-history-of-pediatric-heart-transplant-in-germany-austria-and-switzerland
#15
JOURNAL ARTICLE
Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glöckler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz
COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38430536/systemic-administration-of-cowpea-mosaic-virus-demonstrates-broad-protection-against-metastatic-cancers
#16
JOURNAL ARTICLE
Young Hun Chung, Zhongchao Zhao, Eunkyeong Jung, Anthony O Omole, Hanyang Wang, Lucas Sutorus, Nicole F Steinmetz
The key challenge in cancer treatment is prevention of metastatic disease which is therapeutically resistant and carries poor prognoses necessitating efficacious prophylactic approaches that prevent metastasis and recurrence. It is previously demonstrated that cowpea mosaic virus (CPMV) induces durable antitumor responses when used in situ, i.e., intratumoral injection. As a new direction, it is showed that CPMV demonstrates widespread effectiveness as an immunoprophylactic agent - potent efficacy is demonstrated in four metastatic models of colon, ovarian, melanoma, and breast cancer...
March 2, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38422664/bacitracin-agar-vs-oleandomycin-disk-supplemented-chocolate-agar-for-the-recovery-of-haemophilus-influenzae-in-diagnostic-samples-a-prospective-comparison
#17
JOURNAL ARTICLE
Patrick Forstner, Christina Maria Laireiter, Simone Friedl, Ivo Steinmetz, Karl Dichtl
Haemophilus influenzae is an important pathogen able to cause various forms of respiratory and invasive disease. To provide high sensitivity for detection, culture media must inhibit growth of residential flora from the respiratory tract. This study aimed to identify and compare the diagnostic and economic advantages of using bacitracin containing selective agar (SEL) or oleandomycin disk supplemented chocolate agar (CHOC). Growth and semi-quantitative abundance of H. influenzae and growth suppression of residential flora was prospectively assessed in a 28-week period...
February 2, 2024: Diagnostic Microbiology and Infectious Disease
https://read.qxmd.com/read/38399746/prevalence-of-infective-endocarditis-among-patients-with-staphylococcus-aureus-bacteraemia-and-bone-and-joint-infections
#18
JOURNAL ARTICLE
Matthaios Papadimitriou-Olivgeris, Benoit Guery, Pierre Monney, Laurence Senn, Sylvain Steinmetz, Noémie Boillat-Blanco
We aimed to evaluate the occurrence of infective endocarditis (IE) among patients with bone and joint infections (BJIs) and Staphylococcus aureus bacteraemia. This observational study was conducted at Lausanne University Hospital, Switzerland, from 2014 to 2023, and included episodes involving BJI, S. aureus bacteraemia, and cardiac imaging studies. The endocarditis team defined IE. Among the 384 included episodes, 289 (75%) involved native BJI (NBJI; 118 septic arthritis, 105 acute vertebral or non-vertebral osteomyelitis, 101 chronic osteitis), and 112 (29%) involved orthopedic implant-associated infection (OIAI; 78 prosthetic joint infection and 35 osteosynthesis/spondylodesis infection)...
February 6, 2024: Microorganisms
https://read.qxmd.com/read/38392243/gdf15-contributes-to-the-regulation-of-the-mechanosensitive-responses-of-pdl-fibroblasts-through-the-modulation-of-il-37
#19
JOURNAL ARTICLE
Julia Steinmetz, Albert Stemmler, Christoph-Ludwig Hennig, Judit Symmank, Collin Jacobs
During orthodontic tooth movement (OTM), areas of compressive and tensile forces are generated in the periodontal ligament (PdL), a mechanoreactive connective tissue between the teeth and alveolar bone. Mechanically stimulated PdL fibroblasts (PdLFs), the main cell type of PdL, express significantly increased levels of growth differentiation factor 15 (GDF15). In compressed PdL areas, GDF15 plays a fundamental role in modulating relevant OTM processes, including inflammation and osteoclast activation. However, the specific function of this factor in tensile areas has not yet been investigated...
February 13, 2024: Dentistry Journal
https://read.qxmd.com/read/38385828/fragment-based-design-synthesis-and-characterization-of-aminoisoindole-derived-furin-inhibitors
#20
JOURNAL ARTICLE
Roman W Lange, Konstantin Bloch, Miriam Ruth Heindl, Jan Wollenhaupt, Manfred S Weiss, Hans Brandstetter, Gerhard Klebe, Franco H Falcone, Eva Böttcher-Friebertshäuser, Sven O Dahms, Torsten Steinmetzer
A 1H-isoindol-3-amine was identified as suitable P1 group for the proprotein convertase furin using a crystallographic screening with a set of 20 fragments known to occupy the S1 pocket of trypsin-like serine proteases. Its binding mode is very similar to that observed for the P1 group of benzamidine-derived peptidic furin inhibitors suggesting an aminomethyl substitution of this fragment to obtain a couplable P1 residue for the synthesis of substrate-analogue furin inhibitors. The obtained inhibitors possess a slightly improved picomolar inhibitory potency compared to their benzamidine-derived analogues...
February 22, 2024: ChemMedChem
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