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https://www.readbyqxmd.com/read/27610941/genome-wide-association-study-for-semen-traits-of-the-bulls-in-chinese-holstein
#1
Chunhua Qin, Hongwei Yin, Xu Zhang, Dongxiao Sun, Qin Zhang, Jianfeng Liu, Xiangdong Ding, Yi Zhang, Shengli Zhang
A genome-wide association study (GWAS) was performed to identify markers and candidate genes for five semen traits in the Holstein bull population in China. The analyzed dataset consisted of records from 692 bulls from eight bull stations; each bull was genotyped using the Illumina BovineSNP50 BeadChip. Association tests between each trait and the 41 188 informative high-quality SNPs were achieved with gapit software. In total, 19 suggestive significant SNPs, partly located within the reported QTL regions or within or close to the reported candidate genes, associated with five semen traits were detected...
September 9, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27428872/plasma-phospholipids-and-fatty-acid-composition-differ-between-liver-biopsy-proven-nonalcoholic-fatty-liver-disease-and-healthy-subjects
#2
D W L Ma, B M Arendt, L M Hillyer, S K Fung, I McGilvray, M Guindi, J P Allard
BACKGROUND: There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with perturbations in liver lipid metabolism. Liver phospholipid and fatty acid composition have been shown to be altered in NAFLD. However, detailed profiles of circulating lipids in the pathogenesis of NAFLD are lacking. OBJECTIVE: Therefore, the objective of the present study was to examine circulating lipids and potential mechanisms related to hepatic gene expression between liver biopsy-proven simple steatosis (SS), nonalcoholic steatohepatitis (NASH) and healthy subjects...
2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/26087991/delta-np63-alpha-%C3%A2-responsive-microrna-modulate-the-expression-of-metabolic-enzymes
#3
Edward A Ratovitski
MicroRNAs, whose transcription is regulated by members of the tumor protein p53 family, modulate the expression of numerous metabolic enzymes, significantly altering tumor cell response to chemotherapeutic treatments. The role for ΔNp63α-regulated microRNAs in regulation of cell cycle arrest, apoptosis and autophagy in squamous cell carcinoma (SCC) cells upon cisplatin exposure has been reported. The current study indicated that the selected microRNA targets differentially regulated by ΔNp63α in cisplatin-sensitive and cisplatin-resistant SCC cells could alter the expression of a few metabolic enzymes, thereby potentially contributing to the metabolic changes in SCC cells upon cisplatin exposure...
2015: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/25615281/novel-recurrent-mutations-in-ethanolamine-kinase-1-etnk1-gene-in-systemic-mastocytosis-with-eosinophilia-and-chronic-myelomonocytic-leukemia
#4
T L Lasho, C M Finke, D Zblewski, M Patnaik, R P Ketterling, D Chen, C A Hanson, A Tefferi, A Pardanani
Although KITD816V occurs universally in adult systemic mastocytosis (SM), the clinical heterogeneity of SM suggests presence of additional phenotype-patterning mutations. Because up to 25% of SM patients have KITD816V-positive eosinophilia, we undertook whole-exome sequencing in a patient with aggressive SM with eosinophilia to identify novel genetic alterations. We conducted sequencing of purified eosinophils (clone/tumor sample), with T-lymphocytes as the matched control/non-tumor sample. In addition to KITD816V, we identified a somatic missense mutation in ethanolamine kinase 1 (ETNK1N244S) that was not present in 50 healthy controls...
January 23, 2015: Blood Cancer Journal
https://www.readbyqxmd.com/read/25593331/mutations-of-etnk1-in-acml-and-cmml
#5
COMMENT
Olivier Kosmider
No abstract text is available yet for this article.
January 15, 2015: Blood
https://www.readbyqxmd.com/read/25343957/recurrent-etnk1-mutations-in-atypical-chronic-myeloid-leukemia
#6
COMPARATIVE STUDY
Carlo B Gambacorti-Passerini, Carla Donadoni, Andrea Parmiani, Alessandra Pirola, Sara Redaelli, Giovanni Signore, Vincenzo Piazza, Luca Malcovati, Diletta Fontana, Roberta Spinelli, Vera Magistroni, Giuseppe Gaipa, Marco Peronaci, Alessandro Morotti, Cristina Panuzzo, Giuseppe Saglio, Emilio Usala, Dong-Wook Kim, Delphine Rea, Konstantinos Zervakis, Nora Viniou, Argiris Symeonidis, Heiko Becker, Jacqueline Boultwood, Leonardo Campiotti, Matteo Carrabba, Elena Elli, Graham R Bignell, Elli Papaemmanuil, Peter J Campbell, Mario Cazzola, Rocco Piazza
Despite the recent identification of recurrent SETBP1 mutations in atypical chronic myeloid leukemia (aCML), a complete description of the somatic lesions responsible for the onset of this disorder is still lacking. To find additional somatic abnormalities in aCML, we performed whole-exome sequencing on 15 aCML cases. In 2 cases (13.3%), we identified somatic missense mutations in the ETNK1 gene. Targeted resequencing on 515 hematological clonal disorders revealed the presence of ETNK1 variants in 6 (8.8%) of 68 aCML and 2 (2...
January 15, 2015: Blood
https://www.readbyqxmd.com/read/24612955/genome-wide-association-study-for-poor-sperm-motility-in-holstein-friesian-bulls
#7
D M Hering, K Olenski, S Kaminski
The aim of the study was to screen the whole bull genome to identify markers and candidate genes underlying poor sperm motility. The analyzed data set originates from the Polish Holstein-Friesian bull population and consists of 41 Case and 279 Control bulls (selected from 1581 bulls). The most distinguishing trait of case group was very poor sperm motility (average 25.61%) when compared to control samples (average 72.95%). Each bull was genotyped using the Illumina BovineSNP50 BeadChip. Genome-wide association analysis was performed with the use of GoldenHelix SVS7 software...
May 2014: Animal Reproduction Science
https://www.readbyqxmd.com/read/22208759/analysis-of-the-toxicogenomic-effects-of-exposure-to-persistent-organic-pollutants-pops-in-slovakian-girls-correlations-between-gene-expression-and-disease-risk
#8
Partha Sarathi Mitra, Somiranjan Ghosh, Shizhu Zang, Dean Sonneborn, Irva Hertz-Picciotto, Tomas Trnovec, Lubica Palkovicova, Eva Sovcikova, Svetlana Ghimbovschi, Eric P Hoffman, Sisir K Dutta
The chemical composition of persistent organic pollutants (POPs) in the environment is not uniform throughout the world, and these contaminants contain many structurally different lipophilic compounds. In a well-defined study cohort in the Slovak Republic, the POP chemicals present in the peripheral blood of exposed children were chemically analyzed. The chemical analysis data revealed that the relative concentration and profile of structurally different organic pollutants, including polychlorinated biphenyls (PCBs), 2,2'-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), 2,2'-bis(4-chlorophenyl)-1,1,1-trichloro-ethane (p,p'-DDT), hexachlorobenzene (HCB) and β-hexachlorocyclohexane (β-HCH), may vary from individual to individual, even within the same exposure area...
February 2012: Environment International
https://www.readbyqxmd.com/read/20217129/identification-of-genes-related-to-a-synergistic-effect-of-taxane-and-suberoylanilide-hydroxamic-acid-combination-treatment-in-gastric-cancer-cells
#9
Hyun Chang, Sun Young Rha, Hei-Cheul Jeung, Jae-Jun Jung, Tae Soo Kim, Ho Jeong Kwon, Byung Soo Kim, Hyun Cheol Chung
PURPOSE: We evaluated the cytotoxic effects of combining suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, with taxanes in human gastric cancer cell lines and assessed the pre-treatment difference of gene expression to identify genes that could potentially mediate the cytotoxic response. METHODS: Gastric cancer cell lines were treated with SAHA and paclitaxel or docetaxel, and the synergistic interaction between the drugs was evaluated in vitro using the combination index (CI) method...
December 2010: Journal of Cancer Research and Clinical Oncology
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