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https://www.readbyqxmd.com/read/29783942/effect-of-the-patient-education-learning-and-coping-strategies-in-cardiac-rehabilitation-on-return-to-work-at-one-year-a-randomised-controlled-trial-show-lc-rehab
#1
Birgitte Laier Bitsch, Claus Vinther Nielsen, Christina Malmose Stapelfeldt, Vibeke Lynggaard
BACKGROUND: Personal resources are identified as important for the ability to return to work (RTW) for patients with ischaemic heart disease (IHD) or heart failure (HF) undergoing cardiac rehabilitation (CR). The patient education 'Learning and Coping' (LC) addresses personal resources through a pedagogical approach. This trial aimed to assess effect of adding LC strategies in CR compared to standard CR measured on RTW status at one-year follow-up after CR. METHODS: In an open parallel randomised controlled trial, patients with IHD or HF were block-randomised in a 1:1 ratio to the LC arm (LC plus CR) or the control arm (CR alone) across three Danish hospital units...
May 21, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29782065/foley-catheter-vs-oral-misoprostol-to-induce-labour-among-hypertensive-women-in-india-a-cost-consequence-analysis-alongside-a-clinical-trial
#2
Simon Leigh, Paul Granby, Alan Haycox, Shuchita Mundle, Hillary Bracken, Vaishali Khedikar, Jayashree Mulik, Brian Faragher, Thomas Easterling, Mark A Turner, Zarko Alfirevic, Beverly Winikoff, Andrew D Weeks
OBJECTIVE: To determine the effectiveness and economic impact of two methods for induction of labour in hypertensive women, in low-resource settings. DESIGN: Cost-consequence analysis of a previously reported multi-centre, parallel, open-label randomized trial. SETTING & POPULATION: 602 women with a live fetus, aged>18 years requiring delivery for pre-eclampsia or hypertension, in two public hospitals in Nagpur, India. METHODS: We performed a formal economic evaluation alongside the INFORM clinical trial...
May 21, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29781504/epidural-versus-non-epidural-or-no-analgesia-for-pain-management-in-labour
#3
REVIEW
Millicent Anim-Somuah, Rebecca Md Smyth, Allan M Cyna, Anna Cuthbert
BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects on the mother and infant. This is an update of an existing Cochrane Review (Epidural versus non-epidural or no analgesia in labour), last published in 2011. OBJECTIVES: To assess the effectiveness and safety of all types of epidural analgesia, including combined-spinal-epidural (CSE) on the mother and the baby, when compared with non-epidural or no pain relief during labour...
May 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29778687/droplets-deposition-pattern-from-a-prototype-of-a-fixed-spraying-system-in-a-sloping-vineyard
#4
Stefan Otto, Donato Loddo, Arno Schmid, Christian Roschatt, Maria Venturelli, Gerd Innerebner
In Italy high-quality vines are sometimes grown in small fields with slope steeper than 5-10%, where an air-blast sprayer is impractical so spray-gun application of pesticides is used, a technique that is very costly and labour intensive, and that causes high pesticide exposure of the operators. A possible alternative is the use of a fixed spraying system, and the first researches are in progress in Italy. A fixed spraying system prototype was built in a vineyard at Laimburg Research Centre with an upper line with micro-sprinkler and a lower line with cooler-type nozzles, and a trial was performed with the aim of measuring the deposition pattern of droplets on the row and between rows with water sensitive papers, also in comparison with a precise low-drift air-blast sprayer...
May 17, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29778344/impact-of-clinical-pharmacist-engagement-in-ward-teams-on-the-number-of-drug-related-readmissions-among-swedish-older-patients-with-dementia-or-cognitive-impairment-an-economic-evaluation
#5
Maria Sjölander, Lars Lindholm, Bettina Pfister, Jeanette Jonsson, Jörn Schneede, Hugo Lövheim, Maria Gustafsson
BACKGROUND: Clinical pharmacists play an increasing role in the pharmacological treatment of hospital-admitted older patients with dementia or cognitive impairment. In an earlier randomised controlled trial, clinical pharmacist involvement in the ward team could significantly reduce drug-related readmissions in patient subgroups. However, the economic impact of the intervention has not been addressed so far. OBJECTIVES: To evaluate the economic impact of clinical pharmacist engagement in hospital ward teams for medication therapy management in older patients with dementia or cognitive impairments...
May 16, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#6
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29768662/immersion-in-water-during-labour-and-birth
#7
REVIEW
Elizabeth R Cluett, Ethel Burns, Anna Cuthbert
BACKGROUND: Water immersion during labour and birth is increasingly popular and is becoming widely accepted across many countries, and particularly in midwifery-led care settings. However, there are concerns around neonatal water inhalation, increased requirement for admission to neonatal intensive care unit (NICU), maternal and/or neonatal infection, and obstetric anal sphincter injuries (OASIS). This is an update of a review last published in 2011. OBJECTIVES: To assess the effects of water immersion during labour and/or birth (first, second and third stage of labour) on women and their infants...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29747591/misoprostol-vaginal-insert-versus-misoprostol-vaginal-tablets-for-the-induction-of-labour-a-cohort-study
#8
Daniele Bolla, Saskia Vanessa Weissleder, Anda-Petronela Radan, Maria Luisa Gasparri, Luigi Raio, Martin Müller, Daniel Surbek
BACKGROUND: Misoprostol vaginal insert for induction of labor has been recently reported to be superior to dinoprostone vaginal insert in a phase III trial, but has never been compared to vaginal misoprostol in another galenic form. The aim of this study was to compare misoprostol vaginal insert (MVI) with misoprostol vaginal tablets (MVT) for induction of labor in term pregnancies. METHODS: In this retrospective cohort study we compared 200 consecutive women induced with 200-μg misoprostol 24-h vaginal insert (Misodel®) with a historical control of 200 women induced with Misoprostol 25-μg vaginal tablets (Cytotec®) every 4-6 h...
May 10, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29741208/induction-of-labour-for-improving-birth-outcomes-for-women-at-or-beyond-term
#9
REVIEW
Philippa Middleton, Emily Shepherd, Caroline A Crowther
BACKGROUND: Beyond term, the risks of stillbirth or neonatal death increase. It is unclear whether a policy of labour induction can reduce these risks. This Cochrane review is an update of a review that was originally published in 2006 and subsequently updated in 2012 OBJECTIVES: To assess the effects of a policy of labour induction at or beyond term compared with a policy of awaiting spontaneous labour or until an indication for birth induction of labour is identified) on pregnancy outcomes for infant and mother...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29739349/what-is-the-result-of-vaginal-cleansing-with-chlorhexidine-during-labour-on-maternal-and-neonatal-infections-a-systematic-review-of-randomised-trials-with-meta-analysis
#10
Charlotte Bell, Laura Hughes, Trevor Akister, Vin Ramkhelawon, Amie Wilson, David Lissauer
BACKGROUND: Infection with vaginal microorganisms during labour can lead to maternal and neonatal mortality and morbidity. The objective of this systematic review is to review the effectiveness of intrapartum vaginal chlorhexidine in the reduction of maternal and neonatal colonisation and infectious morbidity. METHODS: Search strategy - Eight databases were searched for articles published in any language from inception to October 2016. Selection criteria - Randomised controlled trials were included...
May 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29736046/quality-of-best-possible-medication-history-upon-admission-to-hospital-comparison-of-nurses-and-pharmacy-students-and-consideration-of-national-quality-indicators
#11
Ashley Sproul, Carole Goodine, David Moore, Amy McLeod, Jacqueline Gordon, Jennifer Digby, George Stoica
Background: Medication reconciliation at transitions of care increases patient safety. Collection of an accurate best possible medication history (BPMH) on admission is a key step. National quality indicators are used as surrogate markers for BPMH quality, but no literature on their accuracy exists. Obtaining a high-quality BPMH is often labour- and resource-intensive. Pharmacy students are now being assigned to obtain BPMHs, as a cost-effective means to increase BPMH completion, despite limited information to support the quality of BPMHs obtained by students relative to other health care professionals...
March 2018: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/29727918/the-inoss-study-of-uterine-rupture-a-descriptive-multi-country-population-based-study
#12
Griet Vandenberghe, Kitty Bloemenkamp, Silvia Berlage, Lotte Colmorn, Catherine Deneux-Tharaux, Mika Gissler, Marian Knight, Jens Langhoff-Roos, Pelle G Lindqvist, Willi Oberaigner, Jos Van Roosmalen, Joost Zwart, Kristien Roelens
OBJECTIVE: International comparison of complete uterine rupture. DESIGN: Descriptive multi-country population-based study. SETTING: International. POPULATION: International Network of Obstetric Survey Systems (INOSS). METHODS: We merged individual data, collected prospectively in nine population-based studies, of women with complete uterine rupture, defined as complete disruption of the uterine muscle and the uterine serosa, regardless of symptoms and rupture of fetal membranes...
May 4, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29720201/creating-a-positive-perception-of-childbirth-experience-systematic-review-and-meta-analysis-of-prenatal-and-intrapartum-interventions
#13
REVIEW
Mahshid Taheri, Amirhossien Takian, Ziba Taghizadeh, Nahid Jafari, Nasrin Sarafraz
BACKGROUND: A negative experience in childbirth is associated with chronic maternal morbidities. The aim of this systematic review and meta-analysis was to identify currently available successful interventions to create a positive perception of childbirth experience which can prevent psychological birth trauma. METHODS: Randomized controlled trials of interventions in pregnancy or labour which aimed to improve childbirth experience versus usual care were identified from 1994 to September 2016...
May 2, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29714572/what-drives-adoption-of-national-labels-as-global-reference-labels-a-case-study-with-the-jpi
#14
Shimon Yoshida, Rie Matsui, Chikara Kikuchi
Pharmaceutical labeling describes the safe and effective use of an approved product. Such information may be provided to consumers and/or health care physicians, and available online or in the pack in a variety of different formats according to local or regional regulations. Depending on the Health Authority (HA), content within a nationally approved label is generally reliant on two primary sources, a Company Core Data Sheet (CCDS), and the text approved by the Health Authority. Content in the nationally approved label may differ from the CCDS for a variety of reasons...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29709558/bursectomy-versus-omentectomy-alone-for-resectable-gastric-cancer-jcog1001-a-phase-3-open-label-randomised-controlled-trial
#15
Yukinori Kurokawa, Yuichiro Doki, Junki Mizusawa, Masanori Terashima, Hitoshi Katai, Takaki Yoshikawa, Yutaka Kimura, Shuji Takiguchi, Yasunori Nishida, Norimasa Fukushima, Yoshiaki Iwasaki, Masahide Kaji, Motohiro Hirao, Hiroshi Katayama, Mitsuru Sasako
BACKGROUND: The role of bursectomy, in which the peritoneal lining covering the pancreas and the anterior plane of the transverse mesocolon are dissected, has long been controversial for preventing peritoneal metastasis. We investigated the survival benefit of bursectomy in patients with resectable gastric cancer. METHODS: This phase 3, open-label, randomised controlled trial was done at 57 hospitals in Japan. Patients aged 20-80 years who had cT3(SS)-cT4a(SE) histologically proven gastric adenocarcinoma with an Eastern Cooperative Oncology Group performance status of 0 or 1 and body-mass index less than 30 kg/m2 and who did not have distant metastasis or bulky lymph nodes were randomly assigned (1:1) during surgery to receive omentectomy alone (non-bursectomy) or bursectomy...
April 27, 2018: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29709454/are-there-differences-between-women-who-choose-elective-repeat-caesarean-versus-trial-of-labour-in-st-john-s-nl
#16
Paul Groves, Joannie Neveu, Colleen Cook, Phil Murphy, Joan M G Crane
OBJECTIVES: To compare the demographic and clinical characteristics between women who chose elective repeat Caesarean section (ERCS) versus trial of labour after Caesarean section (TOLAC) in St. John's, Newfoundland and Labrador (NL). METHODS: We conducted a retrospective case control study of women with live singleton gestations delivering at term in St. John's, NL between January 1, 2001 and December 31, 2014. Inclusion criteria were women who had a previous single lower segment Caesarean section (LSCS)...
April 27, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29708281/pharmacokinetics-safety-and-tolerability-of-obe022-a-selective-prostaglandin-f2%C3%AE-receptor-antagonist-tocolytic-a-first-in-human-trial-in-healthy-post-menopausal-women
#17
Oliver Pohl, Line Marchand, Jean-Pierre Gotteland, Simon Coates, Jörg Täubel, Ulrike Lorch
AIMS: Preterm birth remains a significant risk for later disability. The selective inhibition of the prostaglandin F2α receptor (FP) has significant advantages for a tocolytic. The pro-drug OBE022 and its metabolite OBE002 are novel FP antagonists under development for treating preterm labour. METHODS: We performed a prospective, first in human, Phase I, dose escalation, placebo-controlled, randomised trial at a clinical trial site in the UK. Placebo, single ascending doses (SAD) of 10, 30, 100, 300, 1000 or 1300 mg, and multiple ascending doses (MAD) over seven days of 100, 300 or 1000 mg per day; were administered to post-menopausal female volunteers...
April 30, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29703848/should-empiric-antibiotic-therapy-be-withheld-when-aetiology-of-preterm-birth-is-non-infectious-a-protocol-for-a-systematic-review
#18
Joanna Seliga-Siwecka, Mohammed Toseef Ansari, Judy Aschner, Margaret Sampson, Justyna Romańska
INTRODUCTION: Preterm birth (PTB) at <37 weeks of gestation is the leading cause of perinatal morbidity and mortality in developed countries. The traditional approach has been based on the assumption that PTB is primarily a result of intrauterine infection, which triggers preterm labour and puts the newborn at risk of early onset sepsis (EOS). We are currently experiencing a rise in prematurity that results from maternal and fetal diseases unrelated to infection. We have designed a systematic review to assess whether chemoprophylaxis should be withheld when the aetiology of preterm birth is non-infectious...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29703433/points-to-consider-documents-scientific-information-on-the-evaluation-of-genetic-polymorphisms-during-non-clinical-studies-and-phase-i-clinical-trials-in-the-japanese-population
#19
REVIEW
Masahiro Hiratsuka, Noriyasu Hirasawa, Yoshiteru Oshima, Susumu Kodama, Toshio Miyata, Takashi Dan, Hiroyuki Takatoku, Hideaki Kuribayashi, Ryosuke Nakamura, Yoshiro Saito
Pharmacotherapy shows striking individual differences in pharmacokinetics and pharmacodynamics, involving drug efficacy and adverse reactions. Recent genetic research has revealed that genetic polymorphisms are important intrinsic factors for these inter-individual differences. This pharmacogenomic information could help develop safer and more effective precision pharmacotherapies and thus, regulatory guidance/guidelines were developed in this area, especially in the EU and US. The Project for the Promotion of Progressive Medicine, Medical Devices, and Regenerative Medicine by the Ministry of Health, Labour and Welfare, performed by Tohoku University, reported scientific information on the evaluation of genetic polymorphisms, mainly on drug metabolizing enzymes and transporters, during non-clinical studies and phase I clinical trials in Japanese subjects/patients...
March 15, 2018: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29680084/no-197b-fetal-health-surveillance-intrapartum-consensus-guideline
#20
Robert Liston, Diane Sawchuck, David Young
OBJECTIVE: This guideline provides new recommendations pertaining to the application and documentation of fetal surveillance in the intrapartum period that will decrease the incidence of birth asphyxia while maintaining the lowest possible rate of obstetrical intervention. Pregnancies with and without risk factors for adverse perinatal outcomes are considered. This guideline presents an alternative classification system for antenatal fetal non-stress testing and intrapartum electronic fetal surveillance to what has been used previously...
April 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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