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https://www.readbyqxmd.com/read/28241589/nonlinear-raman-nath-second-harmonic-generation-of-hybrid-structured-fundamental-wave
#1
Huaqing Zhou, Haigang Liu, Minghuang Sang, Jun Li, Xianfeng Chen
We numerically and experimentally investigated the nonlinear Raman-Nath second harmonic generation of hybrid structured fundamental wave whose phase modulation combined periodic and random structure. The second harmonic generation of both one- and two-dimensional hybrid structured fundamental wave were investigated in this paper. The results show that more diffraction spots can be obtained in these hybrid structures than the pure periodic modulation cases. Besides, the total intensity of the second harmonic not only can be dramatically enhanced without altering the diffraction angles, but also is increasing with the degree of randomness of the structure...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28241498/sphingosine-1-phosphate-receptor-1-signaling-in-mammalian-cells
#2
REVIEW
Nigel J Pyne, Susan Pyne
The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P₁-S1P₅. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others...
February 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241450/recent-advances-and-applications-of-molecular-docking-to-g-protein-coupled-receptors
#3
REVIEW
Damian Bartuzi, Agnieszka A Kaczor, Katarzyna M Targowska-Duda, Dariusz Matosiuk
The growing number of studies on G protein-coupled receptors (GPCRs) family are a source of noticeable improvement in our understanding of the functioning of these proteins. GPCRs are responsible for a vast part of signaling in vertebrates and, as such, invariably remain in the spotlight of medicinal chemistry. A deeper insight into the underlying mechanisms of interesting phenomena observed in GPCRs, such as biased signaling or allosteric modulation, can be gained with experimental and computational studies...
February 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28241424/exome-sequencing-in-a-family-with-luminal-type-breast-cancer-underpinned-by-variation-in-the-methylation-pathway
#4
Nicole van der Merwe, Armand V Peeters, Fredrieka M Pienaar, Juanita Bezuidenhout, Susan J van Rensburg, Maritha J Kotze
Panel-based next generation sequencing (NGS) is currently preferred over whole exome sequencing (WES) for diagnosis of familial breast cancer, due to interpretation challenges caused by variants of uncertain clinical significance (VUS). There is also no consensus on the selection criteria for WES. In this study, a pathology-supported genetic testing (PSGT) approach was used to select two BRCA1/2 mutation-negative breast cancer patients from the same family for WES. Homozygosity for the MTHFR 677 C>T mutation detected during this PSGT pre-screen step was considered insufficient to cause bilateral breast cancer in the index case and her daughter diagnosed with early-onset breast cancer (<30 years)...
February 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28241390/patterns-of-parental-care-in-neotropical-glassfrogs-fieldwork-alters-hypotheses-of-sex-role-evolution
#5
Jesse Delia, Laura Bravo-Valencia, Karen M Warkentin
Many animals provide parental care to offspring. Parental sex-roles vary extensively across taxa, and such patterns are considered well documented. However, information on amphibians is lacking relative to other vertebrate groups. We combine natural history observations with functional and historical analyses to examine the evolution of egg care in glassfrogs (Centrolenidae). Parental care was considered rare and predominately provided by males. Our field observations of 40 species revealed that care occurs throughout the family, and the caregiving sex changes across lineages...
February 27, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28241382/passerine-morphology-external-measurements-of-ca-one-quarter-of-passerine-bird-species
#6
Robert E Ricklefs
Studies of community organization and clade diversification that include functional traits have become an important component of the analysis of ecological and evolved systems. Such studies frequently are limited by availability of consistently collected data. Here, I present a dataset including eight measurements of the external morphology of 1642 species, roughly one-quarter of all passerine birds (Aves: Order Passeriformes), from all parts of the world, characterizing the relative proportions of the wing, tail, legs, and beak...
February 27, 2017: Ecology
https://www.readbyqxmd.com/read/28241378/an-experimental-test-of-fitness-variation-across-a-hydrologic-gradient-predicts-willow-and-poplar-species-distributions
#7
Xiaojing Wei, Jessica A Savage, Charlotte E Riggs, Jeannine Cavender-Bares
Environmental filtering is an important community assembly process influencing species distributions. Contrasting species abundance patterns along environmental gradients are commonly used to provide evidence for environmental filtering. However, the same abundance patterns may result from alternative or concurrent assembly processes. Experimental tests are an important means to decipher whether species fitness varies with environment, in the absence of dispersal constraints and biotic interactions, and to draw conclusions about the importance of environmental filtering in community assembly...
February 27, 2017: Ecology
https://www.readbyqxmd.com/read/28241375/specific-gravity-of-woody-tissue-from-lowland-neotropical-plants-differences-among-forest-types
#8
Luisa Fernanda Casas, Ana María Aldana, Francisco Henao-Diaz, Boris Villanueva, Pablo R Stevenson
Wood density, or more precisely, wood specific gravity, is an important parameter when estimating above ground biomass, which has become a central tool for the management and conservation of forests around the world. When using biomass allometric equations for tropical forests, researchers are often required to assume phylogenetic trait conservatism, which allows to assign genus and family level wood specific gravity mean values, to many woody species. The lack of information on this trait for many Neotropical plant species has led to an imprecise estimation of the biomass stored in Neotropical forests...
February 27, 2017: Ecology
https://www.readbyqxmd.com/read/28241263/bridging-knowledge-gaps-to-understand-how-zika-virus-exposure-and-infection-affect-child-development
#9
Bill G Kapogiannis, Nahida Chakhtoura, Rohan Hazra, Catherine Y Spong
Importance: The Zika virus (ZIKV) epidemic has profoundly affected the lives of children and families across the Americas. As the number of children born with ZIKV-related complications continues to grow, the long-term developmental trajectory for these children and the effect on their families remains largely unknown. In September 2016, the Eunice Kennedy Shriver National Institute of Child Health and Human Development and partner National Institutes of Health institutes convened a workshop to develop a research agenda to improve the evaluation, monitoring, and management of neonates, infants, or children affected by ZIKV and its complications...
February 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28241211/families-as-partners-in-hospital-error-and-adverse-event-surveillance
#10
Alisa Khan, Maitreya Coffey, Katherine P Litterer, Jennifer D Baird, Stephannie L Furtak, Briana M Garcia, Michele A Ashland, Sharon Calaman, Nicholas C Kuzma, Jennifer K O'Toole, Aarti Patel, Glenn Rosenbluth, Lauren A Destino, Jennifer L Everhart, Brian P Good, Jennifer H Hepps, Anuj K Dalal, Stuart R Lipsitz, Catherine S Yoon, Katherine R Zigmont, Rajendu Srivastava, Amy J Starmer, Theodore C Sectish, Nancy D Spector, Daniel C West, Christopher P Landrigan, Brenda K Allair, Claire Alminde, Wilma Alvarado-Little, Marisa Atsatt, Megan E Aylor, James F Bale, Dorene Balmer, Kevin T Barton, Carolyn Beck, Zia Bismilla, Rebecca L Blankenberg, Debra Chandler, Amanda Choudhary, Eileen Christensen, Sally Coghlan-McDonald, F Sessions Cole, Elizabeth Corless, Sharon Cray, Roxi Da Silva, Devesh Dahale, Benard Dreyer, Amanda S Growdon, LeAnn Gubler, Amy Guiot, Roben Harris, Helen Haskell, Irene Kocolas, Elizabeth Kruvand, Michele Marie Lane, Kathleen Langrish, Christy J W Ledford, Kheyandra Lewis, Joseph O Lopreiato, Christopher G Maloney, Amanda Mangan, Peggy Markle, Fernando Mendoza, Dale Ann Micalizzi, Vineeta Mittal, Maria Obermeyer, Katherine A O'Donnell, Mary Ottolini, Shilpa J Patel, Rita Pickler, Jayne Elizabeth Rogers, Lee M Sanders, Kimberly Sauder, Samir S Shah, Meesha Sharma, Arabella Simpkin, Anupama Subramony, E Douglas Thompson, Laura Trueman, Tanner Trujillo, Michael P Turmelle, Cindy Warnick, Chelsea Welch, Andrew J White, Matthew F Wien, Ariel S Winn, Stephanie Wintch, Michael Wolf, H Shonna Yin, Clifton E Yu
Importance: Medical errors and adverse events (AEs) are common among hospitalized children. While clinician reports are the foundation of operational hospital safety surveillance and a key component of multifaceted research surveillance, patient and family reports are not routinely gathered. We hypothesized that a novel family-reporting mechanism would improve incident detection. Objective: To compare error and AE rates (1) gathered systematically with vs without family reporting, (2) reported by families vs clinicians, and (3) reported by families vs hospital incident reports...
February 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28241183/association-of-gestational-weight-gain-and-maternal-body-mass-index-in-early-pregnancy-with-risk-for-nonaffective-psychosis-in-offspring
#11
Euan Mackay, Christina Dalman, Håkan Karlsson, Renee M Gardner
Importance: Prenatal exposure to famine is associated with a 2-fold risk for nonaffective psychoses. Less is known about whether maternal nutrition states during pregnancy modify offspring risk for nonaffective psychoses in offspring in well-fed populations. Objective: To determine whether gestational weight gain (GWG) during pregnancy and maternal body mass index (BMI) in early pregnancy are associated with risk for nonaffective psychoses in offspring. Design, Setting and Participants: This population-based cohort study used data from Swedish health and population registers to follow up 526 042 individuals born from January 1, 1982, through December 31, 1989, from 13 years of age until December 31, 2011...
February 22, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28241130/nardostachys-jatamansi-targets-bdnf-trkb-to-alleviate-ketamine-induced-schizophrenia-like-symptoms-in-rats
#12
Anjali Janardhanan, Anjana Sadanand, Arambakkam Janardhanam Vanisree
OBJECTIVE: Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of dopamine and glutamate transmission at NMDA receptors. De-regulated brain-derived neurotrophic factor (BDNF), i.e., its signalling through the tropomyosin receptor kinase B (TrkB) receptor, is a major feature of schizophrenia...
February 28, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28241097/the-gmfwl1-fw2-2-like-nodulation-gene-encodes-a-plasma-membrane-microdomain-associated-protein
#13
Zhenzhen Qiao, Laurent Brechenmacher, Benjamin Smith, Gregory W Strout, William Mangin, Christopher Taylor, Scott D Russell, Gary Stacey, Marc Libault
The soybean gene GmFWL1 (FW2.2-like1) belongs to a plant-specific family that includes the tomato FW2-2 and the maize CNR1 genes, two regulators of plant development. In soybean, GmFWL1 is specifically expressed in root hair cells in response to rhizobia and in nodules. Silencing of GmFWL1 expression significantly reduced nodule numbers supporting its role during soybean nodulation. While the biological role of GmFWL1 has been described, its molecular function and, more generally, the molecular function of plant FW2...
February 27, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28241094/quantification-of-familial-risk-of-nasopharyngeal-carcinoma-in-a-high-incidence-area
#14
Zhiwei Liu, Ellen T Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L Vaughan, Hans-Olov Adami, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Weimin Ye
BACKGROUND: To the authors' knowledge, no studies to date have explored familial risks of nasopharyngeal carcinoma (NPC) in detail and quantified its lifetime risk in high-incidence populations. METHODS: The authors conducted a population-based case-control study of 2499 NPC cases and 2576 controls randomly selected in southern China from 2010 through 2014. Unconditional logistic regression was used to estimate multivariable-adjusted odds ratios (ORs) with 95% confidence intervals (95% CIs) associated with a family history of NPC...
February 27, 2017: Cancer
https://www.readbyqxmd.com/read/28241066/ras-like-family-small-gtpases-genes-in-nilaparvata-lugens-identification-phylogenetic-analysis-gene-expression-and-function-in-nymphal-development
#15
Weixia Wang, Kailong Li, Pinjun Wan, Fengxiang Lai, Qiang Fu, Tingheng Zhu
Twenty-nine cDNAs encoding Ras-like family small GTPases (RSGs) were cloned and sequenced from Nilaparvata lugens. Twenty-eight proteins are described here: 3 from Rho, 2 from Ras, 9 from Arf and 14 from Rabs. These RSGs from N.lugens have five conserved G-loop motifs and displayed a higher degree of sequence conservation with orthologues from insects. RT-qPCR analysis revealed NlRSGs expressed at all life stages and the highest expression was observed in hemolymph, gut or wing for most of NlRSGs. RNAi demonstrated that eighteen NlRSGs play a crucial role in nymphal development...
2017: PloS One
https://www.readbyqxmd.com/read/28241063/role-of-dna-methylation-in-expression-control-of-the-ikzf3-gsdma-region-in-human-epithelial-cells
#16
Sanny Moussette, Abeer Al Tuwaijri, Hamid-Reza Kohan-Ghadr, Samar Elzein, Raquel Farias, Julie Bérubé, Bianca Ho, Catherine Laprise, Cynthia G Goodyer, Simon Rousseau, Anna K Naumova
Chromosomal region 17q12-q21 is associated with asthma and harbors regulatory polymorphisms that influence expression levels of all five protein-coding genes in the region: IKAROS family zinc finger 3 (Aiolos) (IKZF3), zona pellucida binding protein 2 (ZPBP2), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and gasdermins A and B (GSDMA, GSDMB). Furthermore, DNA methylation in this region has been implicated as a potential modifier of the genetic risk of asthma development. To further characterize the effect of DNA methylation, we examined the impact of treatment with DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (5-aza-dC) that causes DNA demethylation, on expression and promoter methylation of the five 17q12-q21 genes in the human airway epithelium cell line NuLi-1, embryonic kidney epithelium cell line 293T and human adenocarcinoma cell line MCF-7...
2017: PloS One
https://www.readbyqxmd.com/read/28241060/nematode-neuropeptides-as-transgenic-nematicides
#17
Neil D Warnock, Leonie Wilson, Cheryl Patten, Colin C Fleming, Aaron G Maule, Johnathan J Dalzell
Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a significant shortcoming in our ability to manage these economically important parasites, and highlights the need for novel and robust control methods. Nematodes can assimilate exogenous peptides through retrograde transport along the chemosensory amphid neurons...
February 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28241032/utilization-of-health-services-in-a-resource-limited-rural-area-in-kenya-prevalence-and-associated-household-level-factors
#18
Anthony K Ngugi, Felix Agoi, Megan R Mahoney, Amyn Lakhani, David Mang'ong'o, Esther Nderitu, Robert Armstrong, Sarah Macfarlane
BACKGROUND AND METHODS: Knowledge of utilization of health services and associated factors is important in planning and delivery of interventions to improve health services coverage. We determined the prevalence and factors associated with health services utilization in a rural area of Kenya. Our findings inform the local health management in development of appropriately targeted interventions. We used a cluster sample survey design and interviewed household key informants on history of illness for household members and health services utilization in the preceding month...
2017: PloS One
https://www.readbyqxmd.com/read/28241020/investigation-of-the-fungal-community-structures-of-imported-wheat-using-high-throughput-sequencing-technology
#19
Yaqian Shi, Yinghui Cheng, Ying Wang, Guiming Zhang, Ruifang Gao, Caiyu Xiang, Jianjun Feng, Dingfeng Lou, Ying Liu
This study introduced the application of high-throughput sequencing techniques to the investigation of microbial diversity in the field of plant quarantine. It examined the microbial diversity of wheat imported into China, and established a bioinformatics database of wheat pathogens based on high-throughput sequencing results. This study analyzed the nuclear ribosomal internal transcribed spacer (ITS) region of fungi through Illumina Miseq sequencing to investigate the fungal communities of both seeds and sieve-through...
2017: PloS One
https://www.readbyqxmd.com/read/28241002/frequency-of-internet-addiction-and-development-of-social-skills-in-adolescents-in-an-urban-area-of-lima
#20
Carlos Orlando Zegarra Zamalloa, Maria Sofía Cuba Fuentes
OBJECTIVES: To determine the frequency of Internet addiction and its relationship with the development of social skills in adolescents in the town of Condevilla, district of San Martin de Porres, Lima - Peru. METHODS: The degree of social skills and level of internet use was evaluated in adolescents from 10 to 19 years of 5th to 11th grades in two secondary schools in the town of Condevilla. Classrooms were randomly selected, and the questionnaires were applied to all adolescents...
January 30, 2017: Medwave
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