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https://www.readbyqxmd.com/read/29151276/microbial-growth-in-building-material-samples-and-occupants-health-in-severely-moisture-damaged-homes
#1
K Järvi, A Hyvärinen, M Täubel, A M Karvonen, M Turunen, K Jalkanen, R Patovirta, T Syrjänen, J Pirinen, H Salonen, A Nevalainen, J Pekkanen
There is no commonly approved approach to detect and quantify the health relevant microbial exposure in moisture damaged buildings. In 39 single-family homes with severe moisture damage, we studied whether concentrations of viable microbes in building material samples are associated with health among 71 adults and 68 children, assessed with symptoms questionnaires, exhaled NO and peak expiratory flow (PEF) variability. Symptoms were grouped into three scores: upper respiratory symptoms, lower respiratory symptoms and general symptoms...
November 19, 2017: Indoor Air
https://www.readbyqxmd.com/read/29151275/rav-transcription-factors-are-essential-for-disease-resistance-against-cassava-bacterial-blight-via-activation-of-melatonin-biosynthesis-genes
#2
Yunxie Wei, Yanli Chang, Hongqiu Zeng, Guoyin Liu, Chaozu He, Haitao Shi
With one AP2 domain and one B3 domain, 7 MeRAVs in apetala2/ethylene response factor (AP2/ERF) gene family have been identified in cassava. However, the in vivo roles of these remain unknown. Gene expression assays showed that the transcripts of MeRAVs were commonly regulated after Xanthomonas axonopodis pv manihotis (Xam) and MeRAVs were specifically located in plant cell nuclei. Through virus-induced gene silencing (VIGS) in cassava, we found that MeRAV1 and MeRAV2 are essential for plant disease resistance against cassava bacterial blight, as shown by the bacterial propagation of Xam in plant leaves...
November 19, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29151266/crystal-structure-and-catalytic-characterization-of-the-dehydrogenase-reductase-sdr-family-member-4-dhrs4-from-caenorhabditis-elegans
#3
Michael Kisiela, Annette Faust, Bettina Ebert, Edmund Maser, Axel J Scheidig
The human dehydrogenase/reductase SDR family member 4 (DHRS4) is a tetrameric protein that is involved in the metabolism of several aromatic carbonyl compounds, steroids and bile acids. The only invertebrate DHRS4 that has been characterized to date is that from the model organism Caenorhabditis elegans. We have previously cloned and initially characterized this protein that was recently annotated as DHRS4_CAEEL in the UniProtKB database. Crystallization and X-ray diffraction studies of the full-length DHRS4_CAEEL protein in complex with diacetyl revealed its tetrameric structure and showed that two subunits are connected via an intermolecular disulfide bridge that is formed by N-terminal cysteine residues (Cys5) of each protein chain, which increases the enzymatic activity...
November 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29151265/cnn3-regulates-neural-tube-morphogenesis-and-neuronal-stem-cell-properties
#4
Dirk Junghans, Sebastian Herzog
Calponin 3 (Cnn3) is a member of the calponin family of actin binding molecules that is highly expressed in the mammalian brain and has been shown to control dendritic spine morphology, density and plasticity by regulating actin cytoskeletal reorganization and dynamics. However, little is known about the role of Cnn3 during embryonic development. In this study we analyzed mutant animals deficient in Cnn3 to gain a better understanding of its role in brain morphogenesis. Embryos lacking Cnn3 exhibited massive malformation of the developing brain including exoencephaly, closure defects at the rostral neural tube and strong enlargement of brain tissue...
November 19, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29151245/hearing-impairment-caused-by-mutations-in-two-different-genes-responsible-for-nonsyndromic-and-syndromic-hearing-loss-within-a-single-family
#5
Katarzyna Niepokój, Agnieszka M Rygiel, Piotr Jurczak, Aleksandra A Kujko, Dominika Śniegórska, Justyna Sawicka, Alicja Grabarczyk, Jerzy Bal, Katarzyna Wertheim-Tysarowska
Usher syndrome is rare genetic disorder impairing two human senses, hearing and vision, with the characteristic late onset of vision loss. This syndrome is divided into three types. In all cases, the vision loss is postlingual, while loss of hearing is usually prelingual. The vestibular functions may also be disturbed in Usher type 1 and sometimes in type 3. Vestibular areflexia is helpful in making a proper diagnosis of the syndrome, but, often, the syndrome is misdiagnosed as a nonsyndromic hearing loss. Here, we present a Polish family with hearing loss, which was clinically classified as nonsyndromic...
November 18, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29151195/risk-factors-in-preschool-children-for-predicting-asthma-during-the-preschool-age-and-the-early-school-age-a-systematic-review-and-meta-analysis
#6
REVIEW
Yixia Bao, Zhimin Chen, Enmei Liu, Li Xiang, Deyu Zhao, Jianguo Hong
PURPOSE OF REVIEW: The aim of this study was to identify risk factors of asthma among children < 6 years old (preschool age) for predicting asthma during the preschool age and early school age (≤ 10 years of age). METHOD OF THE STUDY: MEDLINE, Cochrane, EMBASE, and Google Scholar databases were searched until June 30, 2017. Prospective or retrospective cohort and case-control studies were included. Studies had to have evaluated risk factors or a predictive model for developing asthma in children ≤ 6 years of age or persistent asthma in early school age...
November 18, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29151177/mechanisms-of-drought-induced-dissipation-of-excitation-energy-in-sun-and-shade-adapted-drought-tolerant-mosses-studied-by-fluorescence-yield-change-and-global-and-target-analysis-of-fluorescence-decay-kinetics
#7
Hisanori Yamakawa, Ivo H M van Stokkum, Ulrich Heber, Shigeru Itoh
Some mosses stay green and survive long even under desiccation. Dissipation mechanisms of excess excitation energy were studied in two drought-tolerant moss species adapted to contrasting niches: shade-adapted Rhytidiadelphus squarrosus and sun-adapted Rhytidium rugosum in the same family. (1) Under wet conditions, a light-induced nonphotochemical quenching (NPQ) mechanism decreased the yield of photosystem II (PSII) fluorescence in both species. The NPQ extent saturated at a lower illumination intensity in R...
November 18, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29151163/strengthening-the-healthy-start-workforce-a-mixed-methods-study-to-understand-the-roles-of-community-health-workers-in-healthy-start-and-inform-the-development-of-a-standardized-training-program
#8
Katherine Rachel DeAngelis, Katelyn Flaherty Doré, Deborah Dean, Paul Osterman
Introduction Healthy Start (HS) is dedicated to preventing infant mortality, improving birth outcomes, and reducing disparities in maternal and infant health. In 2014, the HS program was reenvisioned and standardization of services and workforce development were prioritized. This study examined how HS community health workers (CHW), as critical members of the workforce, serve families and communities in order to inform the development of a CHW training program to advance program goals. Methods In 2015, an online organizational survey of all 100 HS programs was conducted...
November 18, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29151162/enrichment-of-lignocellulose-degrading-microbial-communities-from-natural-and-engineered-methanogenic-environments
#9
Emine Gozde Ozbayram, Sabine Kleinsteuber, Marcell Nikolausz, Bahar Ince, Orhan Ince
The aim of this study was to develop an effective bioaugmentation concept for anaerobic digesters treating lignocellulosic biomass such as straw. For that purpose, lignocellulose-degrading methanogenic communities were enriched on wheat straw from cow and goat rumen fluid as well as from a biogas reactor acclimated to lignocellulosic biomass (sorghum as mono-substrate). The bacterial communities of the enriched cultures and the different inocula were examined by 454 amplicon sequencing of 16S rRNA genes while the methanogenic archaeal communities were analyzed by terminal restriction fragment length polymorphism (T-RFLP) fingerprinting of the mcrA gene...
November 19, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29151150/a-comparison-of-cancer-risk-assessment-and-testing-outcomes-in-patients-from-underserved-vs-tertiary-care-settings
#10
Huma Q Rana, Sarah R Cochrane, Elaine Hiller, Ruth N Akindele, Callie M Nibecker, Ludmila A Svoboda, Angel M Cronin, Judy E Garber, Christopher S Lathan
In cancer genetics, technological advances (next generation sequencing) and the expansion of genetic test options have resulted in lowered costs and increased access to genetic testing. Despite this, the majority of patients utilizing cancer genetics services lack diversity of gender, ethnicity, and socioeconomic status. Through retrospective chart review, we compared outcomes of cancer genetics consultations at a tertiary cancer center and a Federally Qualified Health Center (FQHC) (58 tertiary and 23 FQHC patients) from 2013 to 2015...
November 18, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/29151147/the-relationship-of-five-boarding-school-experiences-and-physical-health-status-among-northern-plains-tribes
#11
Ursula Running Bear, Calvin D Croy, Carol E Kaufman, Zaneta M Thayer, Spero M Manson
PURPOSE: American Indian (AI) boarding school attendance is related to poor physical health status; however, little is known about how specific aspects of this experience contribute to poor health. Five experiences (age of first attendance, limited family visits, forced church attendance, prohibition on practicing AI culture and traditions, and punishment for use of AI language) may be independently associated with physical health status in adulthood. We expected the effect to be greater for those who began boarding school at older ages...
November 18, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29151146/mapping-and-confirmation-of-loci-for-salt-tolerance-in-a-novel-soybean-germplasm-fiskeby-iii
#12
Tuyen D Do, Tri D Vuong, David Dunn, Scotty Smothers, Gunvant Patil, Dennis C Yungbluth, Pengyin Chen, Andrew Scaboo, Dong Xu, Thomas E Carter, Henry T Nguyen, J Grover Shannon
The confirmation of a major locus associated with salt tolerance and mapping of a new locus, which could be beneficial for improving salt tolerance in soybean. Breeding soybean for tolerance to high salt conditions is important in some regions of the USA and world. Soybean cultivar Fiskeby III (PI 438471) in maturity group 000 has been reported to be highly tolerant to multiple abiotic stress conditions, including salinity. In this study, a mapping population of 132 F2 families derived from a cross of cultivar Williams 82 (PI 518671, moderately salt sensitive) and Fiskeby III (salt tolerant) was analyzed to map salt tolerance genes...
November 18, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29151135/classification-of-g-protein-coupled-receptors-based-on-a-rich-generation-of-convolutional-neural-network-n-gram-transformation-and-multiple-sequence-alignments
#13
Man Li, Cheng Ling, Qi Xu, Jingyang Gao
Sequence classification is crucial in predicting the function of newly discovered sequences. In recent years, the prediction of the incremental large-scale and diversity of sequences has heavily relied on the involvement of machine-learning algorithms. To improve prediction accuracy, these algorithms must confront the key challenge of extracting valuable features. In this work, we propose a feature-enhanced protein classification approach, considering the rich generation of multiple sequence alignment algorithms, N-gram probabilistic language model and the deep learning technique...
November 18, 2017: Amino Acids
https://www.readbyqxmd.com/read/29151129/one-novel-and-two-uncommon-mefv-mutations-in-japanese-patients-with-familial-mediterranean-fever-a-clinicogenetic-study
#14
Dai Kishida, Masahide Yazaki, Akinori Nakamura, Fumio Nomura, Takeshi Kondo, Takanori Uehara, Masatomi Ikusaka, Akira Ohya, Norihiko Watanabe, Ryuta Endo, Satoshi Kawaai, Yasuhiro Shimojima, Yoshiki Sekijima
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene and characterized by recurrent episodes of fever and polyserositis. To date, over 317 MEFV mutations have been reported, only nine of which account for almost all Japanese patients with FMF. Therefore, the prevalence of rare MEFV variants and their clinical characteristics remains unclear. This study identified MEFV mutations previously unreported in the Japanese population and described their clinical features...
November 18, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29151110/family-oriented-rehabilitation-for-and-rehabilitation-of-adolescents-and-young-adults-aya-in-pediatric-oncology
#15
Konstantin A Krauth
No abstract text is available yet for this article.
November 20, 2017: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29151045/the-physical-and-mental-health-problems-of-refugee-and-migrant-fathers-findings-from-an-australian-population-based-study-of-children-and-their-families
#16
Rebecca Giallo, Elisha Riggs, Claire Lynch, Dannielle Vanpraag, Jane Yelland, Josef Szwarc, Philippa Duell-Piening, Lauren Tyrell, Sue Casey, Stephanie Janne Brown
OBJECTIVES: The aim of this study was to report on the physical and mental health of migrant and refugee fathers participating in a population-based study of Australian children and their families. DESIGN: Cross-sectional survey data drawn from a population-based longitudinal study when children were aged 4-5 years. SETTING: Population-based study of Australian children and their families. PARTICIPANTS: 8137 fathers participated in the study when their children were aged 4-5 years...
November 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/29151042/patient-centered-assessment-on-disease-burden-quality-of-life-and-treatment-satisfaction-associated-with-acromegaly
#17
Shuqian Liu, Daphne T Adelman, Yaping Xu, Jillone Sisco, Susan M Begelman, Susan M Webb, Xavier Badia, Tina K Thethi, Vivian Fonseca, Lizheng Shi
The study aimed to assess the economic burden, health-related quality of life (HRQoL), and acromegaly treatment satisfaction in the USA. A web-based, cross-sectional survey was distributed to members of Acromegaly Community. Data related to comorbidities, treatment patterns, and treatment satisfaction were collected. The costs over the past 3 months included out-of-pocket cost, sick leave, leave of absence, direct loss of job due to acromegaly, unemployment, assistance to perform household chores, and family member loss of income...
November 18, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29151006/the-practical-update-for-family-physicians-in-the-diagnosis-and-management-of-overactive-bladder-and-lower-urinary-tract-symptoms
#18
Jack Barkin, Jeffrey Habert, Amy Wong, Livia Y T Lee
OBJECTIVE: To provide family physicians with an up-to-date, practical overview of the diagnosis and management of overactive bladder (OAB) alone or with bladder outlet obstruction. MAIN MESSAGE: OAB is urinary urgency with or without incontinence, often accompanied by frequency and nocturia, in the absence of urinary tract infection and can affect both men and women. Men often have co-existing OAB associated with bladder outlet obstruction, and benign prostatic hyperplasia...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29150984/how-the-environment-shapes-animal-signals-a-test-of-the-acoustic-adaptation-hypothesis-in-frogs
#19
Sandra Goutte, Alain Dubois, Samuel D Howard, Rafael Márquez, Jodi J L Rowley, J Maximilian Dehling, Philippe Grandcolas, Rongchuan Xiong, Frédéric Legendre
Long distance acoustic signals are widely used in animal communication systems and, in many cases, essential for reproduction. The Acoustic Adaptation Hypothesis (AAH) implies that acoustic signals should be selected for further transmission and better content integrity under the acoustic constraints of the habitat in which they are produced. In the present study, we test predictions derived from the AAH in frogs. Specifically, we focus on the difference between torrent frogs and frogs calling in less noisy habitats...
November 18, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29150970/a-family-reunion
#20
Nicholas Kluesner
She had arrived from home via ambulance for back pain in the middle of the night; elderly patients with back pain are always cases that concern me - nothing chronic seems amenable to satisfying treatment and nothing acute ends well. The paramedics' report was clear: she was the acute type. This article is protected by copyright. All rights reserved.
November 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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