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malaria in pregnancy with pre eclampsia

R L Goldenberg, J B Griffin, B D Kamath-Rayne, M Harrison, D J Rouse, K Moran, B Hepler, A H Jobe, E M McClure
OBJECTIVE: Stillbirths are among the most common adverse pregnancy outcomes, with 98% occurring in low-income countries. More than one-third occur in sub-Saharan Africa (SSA). However, the medical conditions causing stillbirths and interventions to reduce stillbirths from these conditions are not well documented. We estimated the reductions in stillbirths possible with combinations of interventions. DESIGN: We developed a computerised model to estimate the impact of various interventions on stillbirths caused by the most common conditions...
January 2018: BJOG: An International Journal of Obstetrics and Gynaecology
Laura Moro, Azucena Bardají, Eusebio Macete, Diana Barrios, Diana M Morales-Prieto, Carolina España, Inacio Mandomando, Betuel Sigaúque, Carlota Dobaño, Udo R Markert, Daniel Benitez-Ribas, Pedro L Alonso, Clara Menéndez, Alfredo Mayor
BACKGROUND: During pregnancy, syncytiotrophoblast vesicles contribute to maternal tolerance towards the fetus, but also to pathologies such as pre-eclampsia. The aim of the study was to address whether Plasmodium falciparum and HIV infections in pregnancy affect the secretion, microRNA content and function of trophoblast microparticles. METHODS: Microparticles were isolated and characterized from 122 peripheral plasmas of Mozambican pregnant women, malaria- and/or HIV-infected and non-infected...
2016: PloS One
Barthélémy Tandu-Umba, Andy Muela Mbangama
BACKGROUND: Maternal anemia, a common situation in developing countries, provokes impairment of nutrients/oxygen supply to the placenta-fetus unit that leads to Great obstetrical syndromes (GOS). In our setting, however, occurrence of GOS has been found also depending on variables existing prior to pregnancy such as diabetes in family, hypertension in family, previous macrosomia, stillbirth, SGA and pre-eclampsia as well as overweight/obesity. Our study thus aimed to determine the magnitude of maternal anemia and its association with these pre-pregnancy high-risk variables in occurrence of GOS...
2015: BMC Pregnancy and Childbirth
Andreas Chiabi, Seraphin Nguefack, Evelyne Mah, Sostenne Nodem, Lawrence Mbuagbaw, Elie Mbonda, Pierre-Fernand Tchokoteu, Anderson Doh Frcog
OBJECTIVE: The World Health Organization (WHO) estimates that 4 million children are born with asphyxia every year, of which 1 million die and an equal number survive with severe neurologic sequelae. The purpose of this study was to identify the risk factors of birth asphyxia and the hospital outcome of affected neonates. MATERIALS & METHODS: This study was a prospective case-control study on term neonates in a tertiary hospital in Yaounde, with an Apgar score of < 7 at the 5th minute as the case group, that were matched with neonates with an Apgar score of ≥ 7 at the 5th minute as control group...
2013: Iranian Journal of Child Neurology
Joshua P Vogel, Anne C C Lee, João Paulo Souza
BACKGROUND: Preterm birth (PTB) (<37weeks) complicates approximately 15 million deliveries annually, 60% occurring in low- and middle-income countries (LMICs). Several maternal morbidities increase the risk of spontaneous (spPTB) and provider-initiated (piPTB) preterm birth, but there is little data from LMICs. METHOD: We used the WHO Global Survey to analyze data from 172,461 singleton deliveries in 145 facilities across 22 LMICs. PTB and six maternal morbidities (height <145 cm, malaria, HIV/AIDS, pyelonephritis/UTI, diabetes and pre-eclampsia) were investigated...
January 31, 2014: BMC Pregnancy and Childbirth
Sanjeev K Gupta, Dinesh K Pal, Rajesh Tiwari, Rajesh Garg, Ashish K Shrivastava, Radha Sarawagi, Rajkumar Patil, Lokesh Agarwal, Prashant Gupta, Chandrakant Lahariya
The Government of India initiated a cash incentive scheme--Janani Suraksha Yojana (JSY)--to promote institutional deliveries with an aim to reduce maternal mortality ratio (MMR). An observational study was conducted in a tertiary-care hospital of Madhya Pradesh, India, before and after implementation of JSY, with a sample of women presenting for institutional delivery. The objectives of this study were to: (i) determine the total number of institutional deliveries before and after implementation of JSY, (ii) determine the MMR, and (iii) compare factors associated with maternal mortality and morbidity...
December 2012: Journal of Health, Population, and Nutrition
A A Ali, A Okud, A Khojali, I Adam
Medical files of women delivered at Kassala Hospital, Eastern Sudan in the period of January-December 2009 were reviewed retrospectively. Out of 4,689 delivered women, 14.7% were teenagers, 67.1% had no antenatal care and 12.6% were grandmultiparous. Obstetric complications included: pre-term birth (2.6%); pre-eclampsia/eclampsia (4.2%); haemorrhage (2.9%); malpresentation (5.5%); obstructed labour (1.9%) and ruptured uterus (0.6%). Caesarean delivery rate was 31.1%. While 89.4% of the newborn babies were taken home, 6% were admitted to the nursery, 4...
February 2012: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Parinaz Poursafa, Roya Kelishadi
BACKGROUND: Health professionals face the adverse health effects of climate change and air pollution in their practices. This review underscores the effects of these environmental factors on maternal and children's health, as the most vulnerable groups to climate change and air pollution. METHODS: We reviewed electronic databases for a search of the literature to find relevant studies published in English from 1990 to 2011. RESULTS: Environmental factors, notably climate change and air pollution influence children's health before conception and continue during pregnancy, childhood, and adolescence...
2011: Iranian Journal of Nursing and Midwifery Research
Tamara Kredo, Annette Gerritsen, Johan van Heerden, Shaun Conway, Nandi Siegfried
BACKGROUND: Reducing the burden of disease relies on availability of evidence-based clinical practice guidelines (CPGs). There is limited data on availability, quality and content of guidelines within the Southern African Development Community (SADC). This evaluation aims to address this gap in knowledge and provide recommendations for regional guideline development. METHODS: We prioritised five diseases: HIV in adults, malaria in children and adults, pre-eclampsia, diarrhoea in children and hypertension in primary care...
2012: Health Research Policy and Systems
Ishag Adam, Elhassan M Elhassan, Ahmed A Mohmmed, Magdi M Salih, Mustafa I Elbashir
BACKGROUND: Placental malaria and pre-eclampsia occur frequently in women in tropics and are leading causes of maternal and perinatal morbidities and mortality. Few data exist concerning the interaction between placental malaria and pre-eclampsia. METHODS: A case control study was conducted in Medani Hospital, which locates in an area of unstable malaria transmission in Central Sudan. Case (N = 143) were women with pre-eclampsia, which was defined as systolic blood pressure ≥ 140 mm Hg or diastolic blood pressure ≥ 90 mm Hg and proteinuria...
2011: Malaria Journal
Alfred Ian Lee, Maureen M Okam
Anemia in pregnancy is a global health problem affecting nearly half of all pregnant women worldwide. High fetal demands for iron render iron deficiency the most common cause of anemia of pregnancy, with other micronutrient deficiencies contributing less frequently. In certain geographical populations, human pathogens such as hookworm, malarial parasite and human immunodeficiency virus are important factors in anemia of pregnancy. The hemoglobinopathies, sickle cell disease and thalassemia, represent diverse causes of anemia of pregnancy, requiring specialized care...
April 2011: Hematology/oncology Clinics of North America
Demba Sarr, Delphine Aldebert, Laurence Marrama, Emilie Frealle, Alioune Gaye, Hamoud O Brahim, Makhtar Niang, Jean Marie Dangou, Odile Mercereau-Puijalon, Jean Yves Lehesran, Ronan Jambou
BACKGROUND: Placental malaria (PM) is associated with poor foetal development, but the pathophysiological processes involved are poorly understood. Cyclooxygenase (COX) and lipoxygenase (LOX) which convert fatty acids to prostaglandins and leukotrienes, play important roles in pregnancy and foetal development. COX-2, currently targeted by specific drugs, plays a dual role as it associates with both pre-eclampsia pathology and recovery during infection. The role of COX during PM was questioned by quantifying at delivery COX-1, COX-2, 15-LOX, and IL-10 expression in two groups of malaria infected and uninfected placenta...
2010: Malaria Journal
A Oladokun, J A Otegbayo, A A Adeniyi
OBJECTIVE: This study is aimed at determining pregnancy outcome of cases of jaundice in pregnancy over a 10 year period at the University College Hospital, Ibadan. METHODOLOGY: All case records of patients with jaundice in pregnancy over a 10-year period from 1st January 1992 through 31st December 2001 were retrieved from the medical records office of the hospital and analysed. RESULTS: During the ten-year study period, there were 16,566 registered pregnancies in the hospital, and 52 cases of jaundice in pregnancy were seen, giving an overall incidence of 0...
September 2009: Nigerian Journal of Clinical Practice
Elhassan M Elhassan, Omer A Mirghani, Ishag Adam
The aim of this study was to investigate the incidence and causes of maternal deaths and stillbirths at the Hospital of Obstetrics and Gynecology at Wad Medani, Sudan, from 1 January 2003 through 31 December 2007. All maternal deaths and stillbirths during this period were reviewed and classified retrospectively. There were 146 maternal deaths and 33034 live births, giving a maternal mortality ratio of 442/100,000 live births. The age range was 18-42 years with a mean (standard deviation) of 30.57 (5.26) years...
October 2009: Tropical Doctor
Rosalie Grivell, Jodie Dodd, Jeffrey Robinson
Foetal growth restriction is an important and often under-diagnosed complication of pregnancy with important implications for maternal, infant, child and later health. The key to prevention of foetal growth restriction is the recognition of those women at risk and implementation of effective interventions. Ideally, all women should plan pregnancy, providing an opportunity for lifestyle change, reduction of risk factors and optimisation of medical conditions. Failing adequate preconception care, antenatal care should include an assessment of risk factors in early pregnancy, so appropriate interventions may be instituted...
December 2009: Best Practice & Research. Clinical Obstetrics & Gynaecology
Lesley McCowan, Richard P Horgan
There are many established risk factors for babies who are small for gestational age (SGA) by population birth weight centiles (usually defined as <10th centile). The confirmed maternal risk factors include short stature, low weight, Indian or Asian ethnicity, nulliparity, mother born SGA, cigarette smoking and cocaine use. Maternal medical history of: chronic hypertension, renal disease, anti-phospholipid syndrome and malaria are associated with increased SGA. Risk factors developing in pregnancy include heavy bleeding in early pregnancy, placental abruption, pre-eclampsia and gestational hypertension...
December 2009: Best Practice & Research. Clinical Obstetrics & Gynaecology
Geoffrey Tsaras, Amma Owusu-Ansah, Freda Owusua Boateng, Yaw Amoateng-Adjepong
Sickle cell trait occurs in approximately 300 million people worldwide, with the highest prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign carrier state with relative protection against severe malaria, sickle cell trait occasionally can be associated with significant morbidity and mortality. Sickle cell trait is exclusively associated with rare but often fatal renal medullary cancer. Current cumulative evidence is convincing for associations with hematuria, renal papillary necrosis, hyposthenuria, splenic infarction, exertional rhabdomyolysis, and exercise-related sudden death...
June 2009: American Journal of Medicine
J E Siza
According to the World Health Organization low birth weight (LBW) babies are those born with less than 2500g. A descriptive retrospective cross - sectional study using existing data from a one-year (2001) block of birth registers of 3464 pregnant women was done at Kilimanjaro Christian Medical Centre in Moshi, Tanzania. The objective was to determine factors associated with LBW and their contribution to the problem. Out of 648 pregnant women who were tested for HIV infection 59 (9.1%) were positive for the infection...
January 2008: Tanzania Journal of Health Research
Kayode Osungbade, Samuel Oginni, Aderonke Olumide
OBJECTIVE: To assess the contents of antenatal care and to relate the findings to the adequacy of maternal health care. DESIGN: Cross-sectional study. SETTING: Public secondary health-care facilities. PARTICIPANTS: Pregnant women. INTERVENTIONS: Three hundred and ninety consecutive pregnant women attending 12 selected secondary health facilities were recruited proportionate to the client load recorded for each facility during the year preceding the study...
October 2008: International Journal for Quality in Health Care
Jean-Noel Vergnes
UNLABELLED: In this systematic review, several types of infections are identified and investigated: urinary tract infection, periodontal disease, Chlamydia pneumoniae infection, HIV infection, malaria and other persistent bacterial and viral infections. Separate analyses were conducted for each of them. This summary review will only focus on the link between pre-eclampsia and periodontitis, which was just a part of the original systematic review. DATA SOURCES: MEDLINE, EMBASE, POPLINE, CINAHL, LILACS (all from inception to June 30, 2007), proceedings of international meetings on pre-eclampsia, bibliography of the retrieved articles, reviews, chapters in standard textbooks on hypertension in pregnancy, and contact with investigators involved in the field were used to identify relevant studies...
2008: Evidence-based Dentistry
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